Sphingolipid Ceramide N-Deacylase | SCDase | Sphingolipid Hydrolysis
SCDase acts on various acidic and neutral glycosphingolipids and sphingomyelin; however, it exhibits low activity with ...http://www.clontech.com/US/Products/Glycobiology/Glycobiology_Enzymes_and_Reagents/SCDase
Regulation of organelle pH by glycosphingolipids
Subsequently, we found that a lumenal determinant, pH, was less acidic in the TGN and lysosomes of mutant GM95 cells compared ... Even though only about 5 mol% glycosphingolipids are found in cellular membranes, glycosphingolipids are essential during ... we addressed the question how glycosphingolipids regulate the pH. In the cell line lacking glycosphingolipids, we found that ... the precursor of the higher glycosphingolipids. Glycosphingolipids have been implicated in functions as the impermeability ...https://dspace.library.uu.nl/handle/1874/179284
Thus, inhibition of glycosphingolipid metabolism increases insulin sensitivity in retinal neurons.. Glycosphingolipids augment ... Barber AJ, Antonetti DA, Gardner TW: Altered expression of retinal occludin and glial fibrillary acidic protein in experimental ... Inhibiting glycosphingolipid metabolism increased insulin sensitivity in retinal neurons. Glycosphingolipid inhibitors ... 4). Decreased glycosphingolipid synthesis also reduced glucosamine- and IL-1β-induced retinal neuronal cell death (Fig. 6). ...http://diabetes.diabetesjournals.org/content/55/12/3573
Formulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage - Patent application
They have a positive charge in a strongly acidic medium and a negative charge in an alkaline medium. In the neutral pH range, ... glycosphingolipids, cholesterol, phytosterols, chitosan, chondroitin sulfate, lanolin, lanolin esters, amino acids, alpha- ... In aqueous solution they form negatively charged organic ions in an acidic or neutral medium. Cationic surfactants are almost ... In aqueous solution they form positively charged organic ions in an acidic or neutral medium. Amphoteric surfactants contain ...http://www.patentsencyclopedia.com/app/20100286102
Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with...
Another population of T cells, capable of recognizing microbial lipids or self-glycosphingolipids, has been identified (13, 14 ... the sulfate group was removed under mild acidic conditions. Desulfatation of Ac2SGL completely abrogated IFN-γ production (Fig ... correlation of virulence with elaboration of sulfatides and strongly acidic lipids. Infect. Immun. 9:142-149. ... is indirectly supported by the observation that Ac2SGL is presented only when it is internalized by APCs into an acidic ...http://jem.rupress.org/content/199/5/649
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated...
Acidic-SMase (A-SMase) activity was also measured using the same kit but in two-step process. Here, the cell lysate (100 μl/ ... Fine tuning of cell functions through remodeling of glycosphingolipids by plasma membrane-associated glycohydrolases. FEBS Lett ...https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-239
Endoglycoceramidase precursor - Hydra vulgaris (Hydra)
... optimal substrates appear to be the glycosphingolipids with a gangliotetraose structure. ... Hydrolysis of the glycosidic linkage between oligosaccharides and ceramides of glycosphingolipids, ... Highly stable at acidic pH.1 Publication. ,p>Manually curated information for which there is published experimental evidence.,/ ... glycosphingolipid catabolic process Source: UniProtKB ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for ...http://www.uniprot.org/uniprot/Q6L6S1
Phosphate Binding chọn lọc - TaiLieu.VN
Báo cáo khoa học: Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic ... Water-soluble SAPs facilitate the degradation of membrane-bound glyco-sphingolipids with short oligosaccharide chains by ...http://tailieu.vn/tag/phosphate-binding.html
B -lymphocytes and 10-15% of T -lymphocytes. CD35 is caTagorized as a regulator of complement avtivation. It binds complement...
Particles internalized via this pathway experience a drop in pH, towards acidic conditions (pH 5-6), because 79183-19-0 ... is another important pathway which involves small hydrophobic domains that are abundant with cholesterol and glycosphingolipids ...http://recyclers-info.com/tag/b-lymphocytes-and-10-15-of-t-lymphocytes-cd35-is-catagorized-as-a-regulator-of-complement-avtivation-it-binds-complement-components-c3b-and-c4b/
IJMS | Free Full-Text | Deleted in Malignant Brain Tumors-1 Protein (DMBT1): A Pattern Recognition Receptor with Multiple...
Human salivary acidic proline-rich proteins and statherin promote the attachment of Actinomyces viscosus LY7 to apatitic ... "Multivalent" saccharides: Development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens. ... Carlen, A; Bratt, P; Stenudd, C; Olsson, J; Stromberg, N. Agglutinin and acidic proline-rich protein receptor patterns may ... and has been reported for the protein-bacterial interaction between Actinomyces viscosus and acidic proline rich proteins as ...http://www.mdpi.com/1422-0067/11/12/5212/htm
Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to...
Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. J Clin Invest. 2014;124(3):1320-8.View ... Chronic cyclodextrin treatment of murine Niemann-pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage ...https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0880-9
1n69 - Proteopedia, life in 3D
Categories: Human , Ahn, V E , Faull, K F , Fluharty, A L , Prive, G G , Whitelegge, J P , Glycosphingolipid activator protein ... Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by ... Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates ( ...http://proteopedia.org/wiki/index.php/1n69
PSAP Gene - GeneCards | SAP Protein | SAP Antibody
Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with ... Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by ... Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=PSAP&keywords=GH10G071887&prefilter=genomic_location
Molecular Signaling and Cellular Pathways for Virus Entry
Macropinosome vary in size and its acidic environment is beneficial for viruses that are low-pH-dependent in their life cycles ... Lipid rafts are enriching of membrane microdomains with glycosphingolipids and cholesterol, and acts as platforms for protein ... The lumens become more acidic from LE to lysosomes through V-ATPase regulation  and provide the environment for viruses ... and the endosomes provide this acidic compartment. Therefore, the viruses that entry the host cells via clathrin-mediated ...https://www.hindawi.com/journals/isrn/2013/306595/
Evaluation of Fluorescently Labeled Lectins for Noninvasive Localization of Extracellular Polymeric Substances inSphingomonas...
The glycosphingolipid tetrasaccharide also contains galactose, and it could be argued that if WGA binds to the ... Bacteria belonging to the genus Sphingomonas are known to secrete acidic exopolysaccharides (sphingans) that contain a common ... Staining of the biofilms by WGA could only be explained as binding to the Sphingomonas glycosphingolipid membrane, binding to ... 1991) Chemical structure of glycosphingolipids isolated from Sphingomonas paucimobilis. FEBS Lett. 292:107-110. ...https://aem.asm.org/content/66/8/3487?ijkey=fcbaf6747f7bf301d23e2a68412f8e1f14b08c4a&keytype2=tf_ipsecsha
Modulation of Glycosphingolipid Levels by AMP-DNM in HepG2 Cells. HepG2 cells were incubated for up to 72 h with 10 μM AMP-DNM ... Gangliosides were detected as described recently (Ghauharali-van der Vlugt et al., 2008) by analysis of the acidic glycolipid ... Lahiri S and Futerman AH (2007) The metabolism and function of sphingolipids and glycosphingolipids. Cell Mol Life Sci 64: 2270 ... Glycosphingolipids are associated with a wide range of functions, ranging from mediation of cell adhesion to modulation of ...http://jpet.aspetjournals.org/content/326/3/849
LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in...
Boucher R, Larkin H, Brodeur J, Gagnon H, Theriault C, Lavoie C: Intracellular trafficking of LRP9 is dependent on two acidic ... Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J: Inhibition of glycosphingolipid biosynthesis reduces secretion ... Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S: Identification of acidic dileucine signals in LRP9 that interact with both ... The structural elements of APP are depicted, including the cysteine, acidic, carbohydrate, amyloid beta, and cytoplasmic ...https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-7-31
Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo | mBio
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology 44:561-572. doi:10.1002/hep. ... 3), even though these knockout mice have a similar cholesterol/glycosphingolipid accumulation phenotype as filovirus-resistant ... Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage ... and a variety of other cationic amphiphiles also induce accumulation of cholesterol and glycosphingolipids in lysosomes and may ...https://mbio.asm.org/content/6/3/e00565-15
Trends in Glycoscience and Glycotechnology
Next, to investigate the in vivo function of polylactosamine on glycosphingolipids (glycolipid), we analyzed B3gnt5-/- mice ... Sialic acid is an acidic monosaccaride and plays crucial roles in various membrane functions in mammalian central nervous ...https://www.jstage.jst.go.jp/browse/tigg/24/137/_contents/-char/en
IMP: Integrative Multi-species Prediction
phosphoprotein associated with glycosphingolipid microdomains 1. 0.896. ARRB1. arrestin, beta 1. 0.878. ... fibroblast growth factor 1 (acidic). 0.856. CCL5. chemokine (C-C motif) ligand 5. 0.854. ...http://imp.princeton.edu/predictions/process_ortho/human-context-global/13926/?gene=4023
PROF Malcolm McConville - The University of Melbourne
A simple purification of procyclic acidic repetitive protein and demonstration of a sialylated glycosyl-phosphatidylinositol ... characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid.. Journal of Cell Science. 107 ( Pt ...https://www.findanexpert.unimelb.edu.au/display/person338
Acidic sphingomyelinase is localized to the lysosomal compartment (Quintern et al., 1989) and can be secreted to the ... 2007) Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature 449: 62-67. ... There are three major types of sphingomyelinases characterized by their pH optima as acidic, neutral, and alkaline forms, which ... there are also acidic, neutral, and alkaline forms of ceramidases, the hydrolases that deacylate ceramide to sphingosine (el ...http://pharmrev.aspetjournals.org/content/60/2/181
Kudos - helping increase the reach and impact of research
Structure of a highly acidic β-lactamase from the moderate halophileChromohalobactersp. 560 and the discovery of a Cs+- ... Characteristics of thermotropic phase transition of glycosphingolipid (Ganglioside) aggregates in aqueous solution. Published ...https://www.growkudos.com/profiles/40019
Cell proliferation, tumorogenicity, and apoptosis sub-cluster 17
Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the ... ... Trypsin-activated C2II (C2IIa) forms heptamers that bind to the cell receptor and mediate translocation of C2I from acidic ... We studied the endocytosis of fluorescent glycosphingolipid (GSL) analogs in various cell types using pathway-specific ...http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-17-p7.html
Gene Expression in Temporal Lobe Epilepsy is Consistent with Increased Release of Glutamate by Astrocytes | Springer for...
... acidic); FGFR2, Fibroblast growth factor receptor 2; G3PB2, Ras-GTPase activating protein SH3 domain-binding protein 2; GFAP, ... Glial fibrillary acidic protein; KIAA0992, Palladin; MET, Met proto-oncogene (hepatocyte growth factor receptor); MSN, Moesin; ... glial fibrillary acidic protein, ezrin-moesin-radixin, palladin), calcium regulation (S100 calcium binding protein beta, ... Glycosphingolipid Metabolism. GAL3ST1, GALC, PPAP2C, UGT8. SMPD3. Prostaglandin and Leukotriene Metabolism. AKR1C3, CYP4F3, ...https://rd.springer.com/article/10.2119%2F2006-00079.Lee