Loading...
*  Human Metabolome Database: Showing metabocard for Ganglioside GM1 (18:1/12:0) (HMDB0004853)
Gangliosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and ... Ganglioside GM1 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids ... Ganglioside GM1 (18:1/12:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more ... These are neutral glycosphingolipids in which the root sequence is GalNAcb1-4Galb1-4Glc. ...
http://www.hmdb.ca/metabolites/HMDB04853
*  Human Metabolome Database: Showing metabocard for Ganglioside GM2 (d18:0/20:0) (HMDB0011900)
Ganglioside GM2 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids ... A glycosphingolipid (ceramide and oligosaccharide) or oligoglycosylceramide with one or more sialic acids (i.e. n- ... A ganglioside is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n ... This compound belongs to the class of chemical entities known as glycosphingolipids. These are sphingolipids containing a ...
http://www.hmdb.ca/metabolites/HMDB11900
*  Plus it
Thus, inhibition of glycosphingolipid metabolism increases insulin sensitivity in retinal neurons.. Glycosphingolipids augment ... Barber AJ, Antonetti DA, Gardner TW: Altered expression of retinal occludin and glial fibrillary acidic protein in experimental ... Inhibiting glycosphingolipid metabolism increased insulin sensitivity in retinal neurons. Glycosphingolipid inhibitors ... 4). Decreased glycosphingolipid synthesis also reduced glucosamine- and IL-1β-induced retinal neuronal cell death (Fig. 6). ...
http://diabetes.diabetesjournals.org/content/55/12/3573
*  Complex Lipids Flashcards by S S | Brainscape
An oligosaccharide containing one to several acidic sugar derivatives attached to ceramide makes what? ...
https://www.brainscape.com/flashcards/complex-lipids-2234710/packs/3818415
*  LIPID MAPS Lipidomics Gateway
Acidic glycosphingolipids [SP06] Gangliosides [SP0601]. Sulfoglycosphingolipids (sulfatides) [SP0602]. Glucuronosphingolipids [ ...
http://lipidmaps.org/data/classification/LM_classification_exp.php?category=4
*  Search Results - - 20 Results - Digital Library
Gangliosides are acidic glycosphingolipids that contain sialic acid. The high concentration of gangliosides in the central ... The most basic isozyme was more stable than the more acidic isozymes (lower pi values) at pH extremes, at high ionic strength, ... The simultaneous release in ammonia along with the spontaneous shift to more acidic isozymes and changes in the specific ... there was a spontaneous generation of the more acidic isozymes with electrophoretic properties identical to those found in vivo ...
https://digital.library.unt.edu/search/?sort=creator&q5=&searchType=advanced&t5=dc_subject&fq=str_degree_department%3ADepartment+of+Biochemistry
*  Lipid Metabolism sub-cluster 51
Two acidic glycosphingolipids (gangliosides) derived from mouse macrophage membranes and separated by thin-layer chromatography ... Structural analysis and immunohistochemical localization of two acidic glycosphingolipids from the porcine, ... ... The acidic glycolipid fraction (AF) of the porcine, parasitic nematode, Ascaris suum , consisted of two subfractions. The major ... Characterization of cytostatically active glycosphingolipids isolated from thioglycollate-elicited murine macrophages. Schaade ...
http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-51-p9.html
*  Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids | The Journal of Immunology
A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic ... glycosphingolipid. HPTLC. high-performance thin layer chromatography. iGb3. isoglobotrihexosyl ceramide. iNKT cell. invariant ... Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur. J. Immunol. 35: 1692- ... Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. J. Cell Biol. 155: 369-380. ...
http://www.jimmunol.org/content/186/3/1348.long
*  glycosphingolipid biosynthetic process - Semantic Scholar
The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and ... Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. ... glycosphingolipid biosynthetic process. Known as: glycosphingolipid biosynthesis, glycosphingolipid anabolism, ... glycosphingolipid synthesis (More). The chemical reactions and pathways resulting in the formation of glycosphingolipid, a ...
https://www.semanticscholar.org/topic/glycosphingolipid-biosynthetic-process/685741
*  Design of a covalently bonded glycosphingolipid microarray | SpringerLink
Glycosphingolipids (GSLs) are well known ubiquitous constituents of all eukaryotic cell membranes, yet their normal biological ... A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic ... Glycosphingolipid Glycolipid Ganglioside Glycan Lectin Antibody Microarray Glycan array This is a preview of subscription ... Zhang, X., Kiechle, F.L.: Review: glycosphingolipids in health and disease. Ann. Clin. Lab. Sci. 34, 3-13 (2004)PubMedGoogle ...
https://link.springer.com/article/10.1007/s10719-011-9359-9
*  800-342-3595 | Disialoganglioside GD1b (NH4+salt) | Lipids and Biochemicals - Matreya, LLC.
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially ... Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially ...
https://www.matreya.com/bvmodules/producttemplates/matreya/product.aspx?productid=1501
*  Endoglycosylceramidase - Wikipedia
"A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic ... glycosphingolipids". J. Biol. Chem. 261 (30): 14278-82. PMID 3771534. Molecular and Cellular Biology portal. ...
https://en.wikipedia.org/wiki/Endoglycosylceramidase
*  2018 ICD-10-CM Diagnosis Code E75.0: GM2 gangliosidosis
... a subclass of acidic glycosphingolipids.. Code History *2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM ...
https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E75-/E75.0
*  Sphingolipid Ceramide N-Deacylase | SCDase | Sphingolipid Hydrolysis
SCDase acts on various acidic and neutral glycosphingolipids and sphingomyelin; however, it exhibits low activity with ...
http://www.clontech.com/US/Products/Glycobiology/Glycobiology_Enzymes_and_Reagents/SCDase
*  Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling | Nutrition...
Nozaki H, Itonori S, Sugita M, Nakamura K, Ohba K, Suzuki A, Kushi Y: Mushroom acidic glycosphingolipid induction of cytokine ... Kim GY, Roh SI, Ahn SC, Oh YH, Lee JD, Park YM: Alleviation of experimental septic shock in mice by acidic polysaccharide ... α- and β-glucans in lyophilized oyster mushrooms and OMC were determined by acidic and enzymatic hydrolysis using the Mushroom ... Glycosphingolipid, isolated from Pleurotus eryngii, induced secretion of IFN-γ and IL-4 from T-cells [25], whereas β-glucan ...
https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-10-52
*  Mostafa Zarei - Freiburg Institute for Advanced Studies - FRIAS
... assisted laser desorption/ionization mass spectrometry for analysis of neutral and acidic glycosphingolipids" Anal Bioanal Chem ... and structural elucidation of human erythrocytes neutral glycosphingolipid mixture" Anal Chem; 80 (2008): 4711-4722. * Equal ...
http://www.frias.uni-freiburg.de/de/das-institut/archiv-frias/school-of-lifenet/wissenschaftliche-mitarbeiter/zarei
*  Glycolipids - Physics LibreTexts
Acidic glycosphingolipids: These lipids are negatively charged at physiological pH which is provided by N-acetylneuraminic acid ... Glycosphingolipids. Glycosphingolipids are a class of glycolipids which contain ceramide as the lipid complex. Ceramides are ... Glycosphingolipids are derived from lactosylceramide (LacCer; β-D-galactosyl(1→4)-β-D-glucosyl-ceramide) where the first step ... Glycosphingolipids in the plasma membrane can cluster with cholesterol to for rafts which contains less phospholipids relative ...
https://phys.libretexts.org/Courses/University_of_California_Davis/UCD%3A_Biophysics_241_-_Membrane_Biology/Lipids_Types/Glycolipids
*  List of MeSH codes (D09) - Wikipedia
... glycosphingolipids MeSH D09.400.410.420.025 --- acidic glycosphingolipids MeSH D09.400.410.420.025.060 --- antigens, cd15 MeSH ... neutral glycosphingolipids MeSH D09.400.410.420.525.200 --- ceramides MeSH D09.400.410.420.525.200.250 --- cerebrosides MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D09)
*  Glycosphingolipids, Chemistry of - CHEMICAL BIOLOGY
... - reflects the multidimensional character of chemical biology, focusing in ... Role of Multiple Drug Resistance Protein 1 in neutral but not acidic glycosphingolipid biosynthesis. J. Biol. Chem. 2004; 279: ... Chemical Modification of Glycosphingolipids. Studies on the chemical modification of GSLs are not extensive. The sialic acid of ... Inhibitors of glycosphingolipid biosynthesis. L-cycloserine is an inhibitor of serine palmitoyl transferase (85), the first ...
http://schoolbag.info/chemistry/chemical_biology/173.html
*  Observational, retrospective study of a large cohort of patients with Niemann-Pick disease type C in the Czech Republic: a...
... acidic lipids (with cresyl violet); glycosphingolipids (with periodic acid-Schiff); and apolar components (with Sudan Black B ... Lysosomal storage in central neurons was dominated by accumulation of glycosphingolipids, and thus was different from that seen ... One was rapidly frozen for histochemical analyses including detection of phospholipids, sphingomyelin, glycosphingolipids, ... acidic lipids, and apolar components and lipopigments [13], one was fixed with 4% formaldehyde and embedded in paraffin for ...
https://ojrd.biomedcentral.com/articles/10.1186/s13023-014-0140-6
*  G(M2) Ganglioside - Ganglioside GM2 Summary Report | CureHunter
A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 ... Glycosphingolipids: 554*Acidic Glycosphingolipids: 16*Gangliosides: 1633*G(M2) Ganglioside: 179*lysoganglioside G(M2): 3 ... Glycosphingolipids: 554*Acidic Glycosphingolipids: 16*Gangliosides: 1633*G(M2) Ganglioside: 179*lysoganglioside G(M2): 3 ... Glycosphingolipids: 554*Acidic Glycosphingolipids: 16*Gangliosides: 1633*G(M2) Ganglioside: 179*lysoganglioside G(M2): 3 ...
http://www.curehunter.com/public/keywordSummaryD005678-G-M2--Ganglioside-Ganglioside-GM2.do
*  ABO Blood Group as a Model for Platelet Glycan Modification in Arterial ThrombosisSignificance | Arteriosclerosis, Thrombosis,...
Similarly, 5 acidic glycosphingolipids were identified that also express A antigenicity on type A platelets. Although the exact ... Beyond sulfated glycosphingolipids, platelet surfaces express many neutral glycosphingolipids and sialylated glycosphingolipids ... branched glycosphingolipids that express ABH antigenicity on RBCs. Similarly, glycosphingolipids expressing B antigenicity have ... Platelet glycosphingolipids also play a prominent role in platelet activation, aggregation, and thrombosis40-42 by modulating ...
http://atvb.ahajournals.org/content/35/7/1570
*  Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in...
T47D cells with blocked synthesis of sulfatide and MDA-MB-231 cells with neosynthesis of this glycosphingolipid, we showed that ... Accumulation of highly acidic sulfated glycosphingolipids in human hepatocellular carcinoma defined by a series of monoclonal ... Glycosphingolipids in human colonic adenocarcinoma. J Biol Chem. 1978;253(7):2168-75.PubMedGoogle Scholar. ... Immunostaining of neutral glycosphingolipids purified from MDA.SUL cells revealed highly decreased binding of anti-GalCer ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1058-z
*  Frontiers | Role of Gag and lipids during HIV-1 assembly in CD4+ T cells and macrophages | Microbiology
... as well as their enrichment in acidic lipids, some components of raft lipids and in tetraspanin-enriched microdomains. Great ... Acidic Lipid Enriched Microdomains (ALEM). We hypothesize that Gag alone or minimal Gag-RNA complexes are targeted to the PM ... the glycosphingolipid GM3 and to a lesser extend sphingomyelin but not in cholesterol. HIV virions from macrophages are also ... showed that virions from T cells were mainly enriched in acidic lipids (PI, PIP2, PS), GM3, cholesterol and SM (Chan et al., ...
https://www.frontiersin.org/articles/10.3389/fmicb.2014.00312/full
*  Glycosphingolipids | SpringerLink
The enzymes involved in the stepwise degradation of = sphingolipids are exo-hydrolases with optimal activity at acidic pH. A = ... Niemann-Pick disease type C is an exception in that = this complex (glycosphingo-) lipid storage disease is not caused by an = ... Poorthuis B., Aerts J. (2008) Glycosphingolipids. In: Blau N., Duran M., Gibson K. (eds) Laboratory Guide to the Methods in ... enzyme deficiency, but can be considered as a (glycosphingo-)lipid = trafficking defect caused by a deficiency of one of two ...
https://link.springer.com/chapter/10.1007/978-3-540-76698-8_20