Genetic Loci | Harvard Catalyst Profiles | Harvard Catalyst
Achaete-Scute Complex Genome Region. *Locus Control Region. *Major Histocompatibility Complex. *Minor Histocompatibility Loci ... Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates ... Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies. PLoS One. 2018; 13( ...https://connects.catalyst.harvard.edu/Profiles/display/Concept/Genetic%20Loci
Proneural genes - Wikipedia
The formation of neuroblasts depends on the Achaete-scute complex genes - achaete (ac), scute (sc), lethal of scute (lsc) and ... The helixes mediate dimerization, and the adjacent basic region is required for DNA binding. The human genome contains ... Members of achaete-scute complex, such as achaete and scute, as well as ''atonal'' and ''daughterless'' confer to ectodermal ... Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural ...https://en.wikipedia.org/wiki/Proneural_genes
Genomic characterization of a repetitive motif strongly associated with developmental genes in Drosophila | BMC Genomics | Full...
The other copy located in D. virilis is present within the enhancer region of the achaete-scute (ac-sc) complex (Accession No. ... Coding regions constitute a small portion of metazoan genomes, representing ~24% of the small genome of Drosophila melanogaster ... Finishing a whole-genome shotgun: Release 3 of the Drosophila melanogaster euchromatic genome sequence. Genome Biol. 2002, 3: ... This led to the identification of the 25-30 bp motif in many regions of the fly genome (more than 300 hits). This motif does ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-4-52
ASCL2 - Wikipedia
Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene. This gene is a member of the ... Human ASCL2 genome location and ASCL2 gene details page in the UCSC Genome Browser. Miyamoto T, Jinno Y, Sasaki T, Ikeda Y, ... gene region". Journal of Human Genetics. 43 (1): 69-70. doi:10.1007/s100380050041. PMID 9610003. Onions J, Hermann S, ... ASCL2 achaete-scute complex homolog 2 (Drosophila)". Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, ...https://en.wikipedia.org/wiki/ASCL2
SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data ...
... bHLH activators encoded by the achaete-scute complex. Enriched bins (purity ≥50%, P , 0.005) from the proneural activator ... 0 regions of the cluster matrix. This highly unusual genome segment, which we call the A Lot of Su(H) Sites (ALS) region, ... However, these techniques address only part of the informational content of the genome. The complex blueprint that controls the ... The first bin in the matrix where each region was found is marked in Fig. 2; the specifications of each region, including the ...https://www.pnas.org/content/99/15/9888?ijkey=49850802fd5eb72d3d7f6c27c5776a492f361ecc&keytype2=tf_ipsecsha
GSE76652 - Silencing of ASCL1 in U87MG glioma cells - OmicsDI
Notably, a neural reprogramming factor, ASCL1 (achaete-scute complex-like 1), was highly induced by EWS-WT1 in MEFs and in ... INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v15] ... Further analysis demonstrated that EWS-WT1 directly binds to the proximal promoter region of ASCL1 and activates its ... Here we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (NPCs). Interestingly, ...https://www.omicsdi.org/dataset/geo/GSE76652
What's hot today: Current papers in developmental biology and gene function
Most of the achaete-scute complex of the fly Calliphora vicina (including the genes achaete, scute and lethal of scute) have ... This study demonstrates genome-wide and physical association between Nup98 and histone-modifying complexes MBD-R2/NSL and Trx/ ... Copper was found to be concentrated in the copper cell region but also in the region directly anterior to the copper cells and ... The achaete-scute complex has been a useful paradigm for the study of pattern formation and its evolution. achaete-scute genes ...http://www.sdbonline.org/sites/fly/aimain/model-organisms-august2015.htm
PERSPECTIVE: EVOLUTIONARY DEVELOPMENTAL BIOLOGY AND THE PROBLEM OF VARIATION, Evolution | 10.1111/j.0014-3820.2000.tb00544.x |...
Molecular and phenotypic variation in the achaete‐scute region of Drosophila melanogaster ... Complex modular cis ‐acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5 ... The role of the genome project in determining gene function: insights from model organisms ... Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily ...https://www.deepdyve.com/lp/wiley/perspective-evolutionary-developmental-biology-and-the-problem-of-taJ30B1eGC?impressionId=5d070084ced4b&i_medium=docview&i_campaign=references&i_source=references
Mackay and Langley (1990) and Lai and colleagues (1994) have shown that normal allelic variants at the achaete-scute complex ... At this point we have excluded most region of the genome as harboring a QTL and have narrowed our search to several candidate ... Mackay TFC, Langley CH (1990) Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster. Nature ... achaete-scute complex (T1a, T2-T5) control the relative abundance of different classes of neurons. Homologs of several of these ...http://nervenet.org/papers/printfriend/pf_NSFgrant.html
hairy: A Quantitative Trait Locus for Drosophila Sensory Bristle Number | Genetics
1989 Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster. Genetics 122: 607- ... and the achaete-scute complex (Longet al. 2000), was indeed associated with naturally occurring phenotypic variation in bristle ... Position 1 of the alignment corresponds to position 8,591,371 of the 3L sequence of Berkeley Drosophila Genome Project genome ... homozygous h region NIL; (iii) h region NIL as heterozygotes against Sam; h1 (BC20); (iv) h region NIL as heterozygotes against ...http://www.genetics.org/content/162/1/155
Chromosomal Elements Evolve at Different Rates in the Drosophila Genome | Genetics
We can ask whether or not such complexes are conserved in D. repleta. The achaete-scute complex (AS-C) has been studied ... When the physical maps of this region are compared, only a segment of ~130 kb, which includes the genes achaete and scute, has ... 1998 The achaete-scute complex as an integrating device. Int. J. Dev. Biol. 42: 275-282. ... This DNA contains many cis-regulatory sequences that coregulate the achaete and scute (but not the lethal-of-scute and asense) ...https://www.genetics.org/content/161/3/1137?ijkey=3482ffbb2849e6254f9cae12f2cf750a3925c80f&keytype2=tf_ipsecsha
Natural Variation in Neuron Number in Mice Is Linked to a Major Quantitative Trait Locus on Chr 11 | Journal of Neuroscience
Some of these QTLs are now known to correspond to key proneural and neurogenic genes, includingachaete-scute, atonal, enhancer ... Nnc1 maps between Hoxb and Krt1(Watkins-Chow et al., 1996). This region contains three strong candidates for Nnc1: Rara, Thra, ... A genome-wide search using simple and composite interval-mapping techniques revealed a major QTL on chromosome (Chr) 11 in a 3 ... Genetic variation in complex traits is thought to be generated by large numbers of loci that usually have comparatively small ...http://www.jneurosci.org/content/18/1/138.full
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res 2009;69:845- ... A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. ... UTR of mammalian Achaete-Scute Complex homolog 1 (MASH1 or ASCL1), were finally selected. Genomic DNA isolated from peripheral ... UTR of the L-MYC gene MYCL1 and the neuronal development Achaete-Scute Complex homolog ASCL1. Case-control analyses showed that ...http://cancerres.aacrjournals.org/content/71/15/5175
An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian | BMC Biology...
Heitzler P, Bourouis M, Ruel L, Carteret C, Simpson P: Genes of the Enhancer of split and Achaete-Scute complexes are required ... maritima genome only one ASH homologue was identified; a second gene analyzed was too divergent in the basic region of the bHLH ... Skaer N, Pistillo D, Gibert J, Lio P, Wülbeck C, Simpson P: Gene duplication at the achaete-scute complex and morphological ... Dominguez M, Campuzano S: asense, a member of the Drosophila Achaete-Scute complex, is a proneural and neural differentiation ...https://0-bmcbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7007-8-127
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons | Development
... a mouse homolog of the Drosophila achaete scute proneural gene, and Phox2a (Arix - Mouse Genome Informatics) and Phox2b (Pmx2b ... G,H) Prevertebral sympathetic ganglion complex. The celiac superior mesenteric ganglion complex (yellow arrows) surrounding the ... The TGM cDNA encodes a fusion protein composed of N-terminal region of bovine tau, full-length EGFP and three repeats of human ... Guillemot, F., Lo, L.-C., Johnson, J. E., Auerbach, A., Anderson, D. J. and Joyner, A. L. (1993). Mammalian achaete-scute ...https://dev.biologists.org/content/128/20/3963.long
Postnatal Survival of Mice with Maternal Duplication of Distal Chromosome 7 Induced by a Igf2/H19 Imprinting Control Region...
Author Summary Parthenogenetic mouse embryos with two maternal genomes die early in development due to the misexpression of ... Also, it has been suggested that excess expression of the 'achaete-scute complex homolog 2 (Drosophila) (Ascl2) gene could ... Luedi PP, Hartemink AJ, Jirtle RL (2005) Genome-wide prediction of imprinted murine genes. Genome Res 15: 875-884. * View ... probably attributable to the distal region . Second, knockouts of imprinted genes and imprinting control regions (ICRs) ...https://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1000803
Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
Lo, L.-C., Johnson, J. E., Wuenschell, C. W., Saito, T. and Anderson, D. J. (1991). Mammalian achaete-scute homolog 1 is ... the residues in the basic region that interact with DNA are common between Atonal and Scute, and amino acids that differ face ... has been shown to form a complex with Achaete (Mash1 homolog) and Daughterless (E12 homolog), possibly as an adapter protein ... Review - The three-dimensional genome. Guillaume Andrey and Stefan Mundlos summarise the role of 3D chromatin architecture in ...http://dev.biologists.org/content/131/6/1319
Volume 8.24 | Jun 27 - Pulmonary Cell News
The expression of Wnt11 and some neuroendocrine markers increased after the transfection of Achaete-scute complex homolog 1 ( ... Ascl1 regulated Wnt11 expression via lysine H3K27 acetylation at the enhancer region of the WNT11 gene. [Lab Invest] Abstract ... Cells were characterized by morphology, proliferation and transepithelial electrical resistance, whole genome transcription ...http://www.pulmonarycellnews.com/issue/volume-8-24-jun-27/
Poils au dos
... regulatory enhancer sequences at the achaete-scute complex that mediate activation at specific sites on the notum. The target ... Within the region delimited above, a 3.7 kb stretch upstream of the scute ATG, containing both the SOP enhancer and an enhancer ... It is the most closely related gene to pad in the D. melanogaster genome according to Blast analysis (Gibert, 2005). pad is ... simulans provides evidence for divergence of cis-regulatory sequences in the achaete-scute gene complex. Dev. Biol. 221(1): 148 ...http://www.sdbonline.org/sites/fly/hjmuller/poils-au-dos1.htm
Frontiers | Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits | Genetics
Three QTL influencing post-weaning growth map to the proximal end of BTA2 [linkage region of 0 - 9 cM; genomic region of 5.0 - ... Three QTL influencing post-weaning growth map to the proximal end of BTA2 [linkage region of 0 - 9 cM; genomic region of 5.0 - ... Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in ... We identified 24 POE-QTL on 15 Bos taurus autosomes (BTAs) of which 6 were significant at 5% genome-wide level and 18 at the 5 ...https://www.frontiersin.org/articles/10.3389/fgene.2011.00044/full
The nuclear matrix protein EAST affects the transcription of Drosophila melanogaster genes irrespective of the presence of...
... an increase in the EAST concentration had no effect on the expression of mutant alleles of the achaete-scute complex, some of ... either in heterochromatin or in telomeric regions of chromosome 4, as well as on the repression induced by ... whole genome and whether there was a correlation. between the EAST-dependent repression and the ... an increase in the EAST concentration had no effect on the expression of mutant alleles of the achaete-scute complex, some of ...https://www.deepdyve.com/lp/springer_journal/the-nuclear-matrix-protein-east-affects-the-transcription-of-ZYJrNgKVYg
Transcription factor - Wikipedia
The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate. ... 1.2.3 Family: Achaete-Scute. *1.2.4 Family: Tal/Twist/Atonal/Hen ... Thus, given the genome sequence it is still difficult to ... "Genome Informatics. International Conference on Genome Informatics. 15 (2): 276-86. PMID 15706513. Archived from the original ... The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more ...https://en.m.wikipedia.org/wiki/Transcription_factor
Role of Menin in Neuroendocrine Tumorigenesis | SpringerLink
An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997; 386(6627):852-5.CrossRef ... Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet 2006; 2(4):e51.CrossRefPubMedGoogle ... Leukemia proto-oncoprotein MLL forms a SET1-like histone merhyltransferase complex with menin to regulate Hox gene expression. ... transcriptional regulation by dual inhibitory regions. Cell Growth Differ 1997; 8(6):677-86.PubMedGoogle Scholar ...https://link.springer.com/chapter/10.1007/978-1-4419-1664-8_9
Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation | PNAS
2015) Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517:583-588. ... 1 D-H). Nevertheless, this combination did not exhibit very strong activation of endogenous achaete-scute homolog 1 (ASCL1) ... bFaculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region 999077, China ... 2013) Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 31:230-232. ...http://www.pnas.org/content/115/29/E6722
Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens | G3: Genes | Genomes...
2002 How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292: 1-12. ... 1995 Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans. ... Cis-regulatory sequences are typically located in noncoding regions of the genome and work by binding trans-regulatory ... Subcloning regions of yellow noncoding sequences. Fragments from the 5′ intergenic and intronic regions of yellow from D. ...http://www.g3journal.org/content/6/10/3419