... flanking region of many phase II detoxification enzymes. Check for active clinical trials using this agent. (NCI Thesaurus). ... flanking region of many phase II detoxification enzymes.. bromelain. A proteolytic enzyme obtained from the pineapple plant ... This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical ... Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and ...
5-aza-2′-deoxycytidine (AZA) is a DNA demethylating and anti-cancer agent resulting in induction of genes suppressed via DNA ... flanking region of TAGLN promoter, and in vitro methylation of the CpG dinucleotides within this region, Yamamura et al. [39] ... The promoter region of TAGLN, one of the strongest candidate genes among many probe sets, was previously found to be methylated ... Bisulfite sequencing of TAGLN promoter region was used to characterize TAGLN methylation status in eight BC and two NTB cell ...
Zero Flank Seed Length]. Length in nucleotides of a sequence flank surrounding a zero-mapped read region of the genome used in ... MUT.flanks - File containing sequence flanks clipped proximal to zero read depth regions. Contains basic position and ... matchg.pl --flanks. Parses MUT.zero file and clips sequence flanks to attempt to resolve insertion/deletion mutations. ... Zero Flank Step]. For coverage gap resolution. Number of bases beyond a zero mapped read location to move before defining a ...
... flanking region for two possible transcription initiation sites, or in the case of two different mRNA sequences encoded by a ... Shen, J; Bao, Y; Chen, Y T (1997) A nonsense mutation due to a single base insertion in the 3-coding region of glycogen ... single gene, sequencing the regions of the gene that specify the mRNA unique to liver or muscle. The defective chromosomal ... structure of glycogen debrancher gene and human mutants lacking debrancher activity may lead to identifying DNA regions ...
Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any. ... 5. PSEBR_RS10605. 2431509..2433014 [-], 1506. 503458073. conjugal transfer protein TraG. Tfc19. ...
Description: Rabbit polyclonal EIF2C4 antibody raised against the middle region of EIF2C4 ... Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target ... Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target ... Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target ...
... flanking region was cloned into the reporter vector. All of the truncated TG2 promoter constructs had the same 3-end. One of ... flanking region (-1572/+217, -1205/+217, -851/+217, -392/+217, and -35/+217) were cloned into the reporter vector. HepG2 was co ... B) A conserved STAT3 binding motif was located in the region of -317 to -307. Mutagenesis was performed to destroy STAT3 ... H-CAFs were isolated from the cancerous regions of the tumor samples from HCC patients, as described previously [10]. Normal ...
... to a mutant target sequence chosen from the HBV preCore region and/or to a mutant target sequence chosen from the HBsAg region ... with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT pol gene region and/or ... 285-296, "Nucleotide sequence of integrated hepatitis B virus DNA and human flanking regions in the genome of the PLC/PRF/5 ... The Term "mutation region" means the region in the relevant HBV gene sequence where at least one mutation encoding a HBV mutant ...
One of those flanked a region of indels, i.e., insertions or deletions downstream of the K domain. The 75 amino acids compared ... These six MADS-BOX-type genes form a cluster in the wild-type genome, while there is a 41,746-bp deletion in the same region of ... The presence of a conserved core sequence motif (CCGAC) in the promoter region of DAM5 and DAM6 genes in peach and Japanese ... 2008) made a comparative mapping to a 132-kb region of the wild-type genome where six genes were found to be missing from ...
... flanking region. Biochim Biophys Acta. 2000 Mar 17. 1500 (3):323-34. [QxMD MEDLINE Link]. ... flanking region. Genomics. 1994 Mar 1. 20 (1):99-104. [QxMD MEDLINE Link]. ... 1, 2, 3, 4, 5, 6, 7, 8] The severity of bone and cartilage damage differs by the type of bone affected. Affected bone with ... 4] At age 5 months, adduction of both thumbs was recognized, and, at age 18 months, a chest abnormality was noticed. At age 3 ...
... flanking region of salicylate hydroxylase gene, and identification and purification of a LysR-type regulator, SalR.. 2001 Apr ... InChI=1S/2C7H6O3.Mg/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2 ... It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic ... Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine ...
... flanking genomic regions of the mouse ARF gene, respectively (Figure 1A). A chimeric ARF-DTR-2A-luc PAC transgenic construct ... The subcloned DTR-2A-luc fragment was flanked by 30 nucleotide sequences of the ARF gene untranslated region and the exon ... a rpsL-neo counter selection cassette flanked by two adjacent sequences of the start codon of the ARF gene was amplified by PCR ... Figure 5. Restoration of lung function by eliminating p19ARF-expressing cells. (A) Pressure-volume curves of ARF-diphtheria ...
... flanking region are required for embryo-specific gene expression.",. author = "Bustos, {M. M.} and Guiltinan, {M. J.} and J. ... flanking region are required for embryo-specific gene expression.. AB - A 0.8-kilobase fragment from the 5-flanking region of ... flanking region of a French bean beta-phaseolin gene yielded strong, temporally regulated, and embryo-specific expression of ... flanking region of a French bean beta-phaseolin gene yielded strong, temporally regulated, and embryo-specific expression of ...
... flanking region of the gene for the cAMP-inducible protein kinase A subunit, RIIbeta, in Sertoli cells. Mol Cell Endocrinol, ... DOI 10.1210/endo-129-5-2496, PubMed 1657577 Taskén KA, Knutsen HK, Attramadal H, Taskén K, Jahnsen T, Hansson V, Eskild W (1991 ... Carcinogenesis, 42 (5), 685-693. DOI 10.1093/carcin/bgab015, PubMed 33609362 Ramirez-Garrastacho M, Bajo-Santos C, Line A, ... JAMA Netw Open, 5 (1), e2145230. DOI 10.1001/jamanetworkopen.2021.45230, PubMed 35080602 ...
The most compelling candidate genes in these two regions included the growth hormone gene (GH1) on SSC12 and PRKD1 on SSC7. ... For regions previously reported by Tart et al. [26] likely candidate genes are CRTC1 (SSC2:59 Mb), PAPPA (SSC1:288 Mb), CCT6A ( ... Six regions contained genes associated with age at menarche in humans, and identified by Tart et al. [26] as well as the ... Markers in this region on SSC8 showed high linkage disequilibrium that extended for about 2 Mb (71.8-73.8 Mb) and includes the ...
AN SH3 BINDING REGION IN THE EPITHELIAL NA+ CHANNEL (ALPHA-RENAC) MEDIATES ITS LOCALIZATION AT THE APICAL MEMBRANE EMBO JOURNAL ... This promoter activity was enhanced 2.5- and 4-fold by upstream flanking sequences. Dexamethasone treatment induced levels of ... Gel shift assays showed protein-DNA binding activity of an AP-1 consensus site in this region; however, mutation of the AP-1 ... This suggests that the inhaled sub-micronic aerosol of 99mTc-DTPA was deposited predominately in a region of the lung with a ...
... flanking region, and also found that GRIK5 displays features of a housekeeping gene. Our analysis in rat neural cells and in ... At NCI, I have participated in two large nutritional-intervention clinical trials in Linxian, China, a region with ... flanking sequence restricts tissue-specific expression of this GluR gene in vitro and in vivo. Now, we are working on ... nonneural rat and human cells, as well as in transgenic mice, demonstrated that a region of GRIK5s 5- ...
... flanking region of the mlf gene (open box) and the 3′ -flanking region of the ran gene (dotted box). The filled black box ... In construct pgCas9, the cas9 gene is flanked by gdh promoter (striated box) and 3′ untranslated region of the ran gene (dotted ... flanking region of the mlf gene as homologous arms. The Cas9/gRNA cutting site in the genomic mlf gene is indicated by a red ... flanking regions of the gdh gene (striated box). In constructs pPMLF and pPhMLF2, the mlf and hmlf2 genes are under the control ...
The region of qRgls2 was narrowed further, flanked by markers G346 and DD11. ... A total of 15 genes were predicted in the mapped region. It is assumed that qRgls2 could be widely used to improve maize ... A major GLS resistance QTL, qRgls2, was previously detected in the centromere of chromosome 5. By using advanced backcross ...
... flanking region of that transcript. --gcs-max-retries. -gcs-retries 20. If the GCS bucket channel errors out, how many times it ... flanking region of that transcript. --transcript-list. File to use as a list of transcripts (one transcript ID per line, ... Variant is in coding region of the chosen transcript, but protein structure is identical. Can occur in Coding regions or ... five-prime-flank-size Variants within this many bases of the 5 end of a transcript (and not overlapping any part of the ...
By analyzing different 5′ deletion mutants of these promoters, it was determined that TaGAPCp2P (− 1312~ − 528) and TaGAPCp3P ... flanking region of the structural gene and is capable of specifically recognizing and binding RNA polymerase, which regulates ... The 1822 bp of TaGAPCp2 5regulatory region and 2049 bp of TaGAPCp3 5regulatory region were obtained by PCR and cloned into ... The full-length TaGAPCp2P/3P regions were amplified by PCR using specific primers (Ta1301-2/3F and Ta1301-2/3R). Then, the ...
... flanking regions of these starch synthesis-related genes tended to be enriched by ChIP, suggesting that CRCT can bind to the ... promoter regions of these genes. The monomer of CRCT is 34.2 kDa, however CRCT was detected at 270 kDa via gel filtration ... using a FLAG-CRCT overexpression line and subsequent qPCR analyses showed that the 5- ...
... flanking region nt − 1000 to + 20 of the IFNε gene was synthesized and cloned in the Promega pGL3 luciferase reporter basic ... To assess the IFNε promoter activity, the pGL3 or pGL3 with IFNε promoter region was transfected into A2EN (0.125μg plasmid DNA ... 9]. The discrepancy may be due to the different promoter region (Matumiya, nt − 497 to + 296 vs nt − 1000 to + 20 in this study ... Cells were limited to 5-6 passages. Primary cervical cells were prepared based on published protocols with modification [16]. ...
... flanking region is relatively free of nucleosomes [127] (Figure 1A,F). Because nucleosome positioning was performed using ... large numbers of CHG and CHH SMPs occurred in flanking regions. Thus, novel inherited SMPs are generated at high frequencies ... Each nucleosome has the potential to bind 14 such 2 bp regions. B. One 10 bp region of the DNA helix with the consensus ((Y) ... in a 286 bp contiguous region [73]. Hypermethylation of this region and silencing of the CNR gene leads to colorless tomatoes ...
Zhang, M. Q. (May 1998) Statistical features of human exons and their flanking regions. Human Molecular Genetics, 7 (5). pp. ... Zhang, M. Q. (July 1998) Identification of protein-coding regions in Arabidopsis thaliana genome based on quadratic ... The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence ... 190-5. ISSN 1087-0156 Li, R., Yu, D. S., Tanaka, M., Zheng, L., Berger, S. L., Stillman, B. (March 1998) Activation of ...
... flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. Arthritis Rheum 2001; 44 ... 5: 262-265.. *Mavragani CP, Yiannakouris N, Zintzaras E et al. Analysis of SAA1 gene polymorphisms in the Greek population: ... A novel single-nucleotide polymorphism at the 5- ...
... flanking region, which contains putative regulatory sequences. Comparison of the genomic and cDNA sequences indicates that the ... flanking region, which contains putative regulatory sequences. Comparison of the genomic and cDNA sequences indicates that the ... flanking region, which contains putative regulatory sequences. Comparison of the genomic and cDNA sequences indicates that the ... flanking region, which contains putative regulatory sequences. Comparison of the genomic and cDNA sequences indicates that the ...
... flanking region of the human TH gene fused to a reporter gene. chloramphenicol acetyltransferase (CAT), and designated them as ... deletions in the loop region (669-713) and in the C-terminal region of alpha-DG (550-645) abolish the cleavage, (iii) ... In this study, we used a brain-region specific knock-in mouse expressing an NMDA receptor that is defective for the Mg2+ block ... These results indicate that the 5.0-kb DNA fragment of the TH gene upstream region contains activity to express CAT in CAnergic ...
We present evidence for recent positive selection in the FOXI1 gene region in Africa. Climate might be related to this recent ... 20 East Asians and 20 Yorubas and by analysing SNP variation in a 2 Mb region centered on FOXI1 in 39 worldwide human ... end flanking regions; from this point, an extra SNP was then added every 40 kb up to around 200 kb in both flanking regions. ... iHS values for individual SNPs flanking the FOXI1 region (2 Mb) against physical distance (top panel) and p-values for the ...
... flanking region was stimulatory but not obligatory for conferring the reactivating activity upon E. coli. Thus, the product of ... flanking region was stimulatory but not obligatory for conferring the reactivating activity upon E. coli. Thus, the product of ... flanking region was stimulatory but not obligatory for conferring the reactivating activity upon E. coli. Thus, the product of ... flanking region was stimulatory but not obligatory for conferring the reactivating activity upon E. coli. Thus, the product of ...