AKR1C3 - Wikipedia
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11 ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...https://en.wikipedia.org/wiki/AKR1C3
3α-Hydroxysteroid dehydrogenase - Wikipedia
HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...https://en.wikipedia.org/wiki/3%CE%B1-Hydroxysteroid_dehydrogenase
Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. - PubMed - NCBI
... alpha--,beta)-hydroxysteroid epimerase were significantly higher in Om fat. 3Alpha/beta-HSD activity was mainly detected in the ... Experiments with isoform-specific AKR1C inhibitors in preadipocytes showed that AKR1C2 inhibition significantly decreased ... hydroxysteroid dehydrogenase type 2) and 3( ... 2006 Dec;191(3):637-49. Research Support, Non-U.S. Gov't ... J Endocrinol. 2006 Dec;191(3):637-49.. Androgen inactivation and steroid-converting enzyme expression in abdominal adipose ...https://www.ncbi.nlm.nih.gov/pubmed/17170221
RCSB PDB - 1AFS: RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND...
... crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. ... Androsterone Dehydrogenase Activity * Androsterone Dehydrogenase (b Specific) Activity * Steroid Metabolic Process * ... Alpha Beta Alpha-Beta Barrel TIM Barrel NADP-dependent oxidoreductase B. 1afsB00. Alpha Beta Alpha-Beta Barrel TIM Barrel NADP- ... Alpha and beta proteins (a/b) TIM beta/alpha-barrel NAD(P)-linked oxidoreductase Aldo-keto reductases (NADP) 3-alpha- ...http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1AFS
RCSB PDB - 1FJH: THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER...
... reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain ...http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1FJH
3alpha-hydroxysteroid dehydrogenase (B-specific). (EC 184.108.40.206). hydroxyprostaglandin dehydrogenase. (EC 220.127.116.11). 3alpha- ... Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H. ... 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional ... The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel ...http://ezcatdb.cbrc.jp/EzCatDB/search/get.do?dbcode=S00325
'Junk' DNA: Why non-coding DNA Isn't Really...
Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (26), the alpha-globin The ... alcohol dehydrogenase (32), 3 alpha-hydroxysteroid dehydrogenases (33), apolipoprotein A-II (34), beta1,4-N- ... Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (36), Alpha-1 acid ... Properties of the mouse alpha-globin HS-26: relationship to HS-40, the major enhancer of human alpha-globin The functional and ...http://www.godandscience.org/evolution/junkdna.html
Human Metabolome Database: Showing metabocard for 7 alpha-Hydroxy-3-oxo-4-cholestenoate (HMDB0012458)
2. 3 beta-hydroxysteroid dehydrogenase type 7. General function:. Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase ... Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 7 alpha-Hydroxy-3-oxo-4-cholestenoate is created from either 3 beta,7 alpha-Dihydroxy-5-cholestenoate or 7 alpha,26-Dihydroxy-4 ... 7 alpha-Hydroxy-3-oxo-4-cholestenoate. Description. 7 alpha-Hydroxy-3-oxo-4-cholestenoate is involved in the primary bile acid ...http://www.hmdb.ca/metabolites/HMDB12458
Human Metabolome Database: Showing metabocard for 7 alpha,26-Dihydroxy-4-cholesten-3-one (HMDB0012459)
Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 26-hydroxysteroid. *Dihydroxy bile acid, alcohol, or derivatives. *3-oxo-delta-4-steroid ... 7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. Gene Name:. CYP27A1. Uniprot ID:. Q02318 Molecular ... 7 alpha,26-Dihydroxy-4-cholesten-3-one. Description. 7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid ...http://www.hmdb.ca/metabolites/HMDB0012459
Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from...
The enzyme 20 alpha-hydroxysteroid dehydrogenase (20 alpha SDH) has previously been shown to be a specific enzyme marker of ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ...https://www.jimmunol.org/content/126/6/2184
Intersex Variations, Human Rights, and the International Classification of Diseases - Health and Human Rights Journal
World Health Organization, "46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency," in ICD ... Specific ICD codes Individual codes in the ICD-11-MMS and ICD-11 Foundation typically contain both a title and description. In ... World Health Organization, "46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency", in ICD-11 Foundation, ... and 17-beta-hydroxysteroid dehydrogenase 3 deficiency (17ß-HSD3) are notable. Each of these variations are associated with ...https://www.hhrjournal.org/2018/08/intersex-variations-human-rights-and-the-international-classification-of-diseases/
BRENDA - 18.104.22.168: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha- ... 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido- ... hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)- ... 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, ...http://www.brenda-enzymes.org/all_enzymes.php?ecno=22.214.171.124&table=Storage_Stability
anti-AKR1C3 antibody [C2C3], C-term | GeneTex
3-alpha hydroxysteroid dehydrogenase, type II)) for ICC/IF, IHC-P, IP, WB. Anti-AKR1C3 pAb (GTX104627) is tested in Human, Rat ... 2-diol dehydrogenase antibody, testosterone 17-beta-dehydrogenase 5 antibody, indanol dehydrogenase antibody, aldo-keto ... 1 mg/ml (Please refer to the vial label for the specific concentration). ... dihydrodiol dehydrogenase X antibody, chlordecone reductase homolog HAKRb antibody, 3-alpha-HSD type II, brain antibody, ...http://www.genetex.com/AKR1C3-antibody-C2C3-C-term-GTX104627.html
Recombinant human HSD3a protein (ab109831) | Abcam
Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to ... Specific activity is , 700 pmol/min/μg, and is defined as the amount of enzyme that catalyzes the reduction of 1.0 pmole 3- ... Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3- ...https://www.abcam.com/recombinant-human-hsd3a-protein-ab109831.html
The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester | SpringerLink
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. J Clin Endocrinol Metab ... Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3 beta-hydroxysteroid dehydrogenase/ ... Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta- ... hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of ...https://link.springer.com/article/10.1186/s12916-018-1009-7
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole - Full Text View -...
... hydroxysteroid [17-beta] dehydrogenase [HSD17B]3, HSD17B6, AKR1C2, AKR1C1, UGTB15, UGTB17, steroid-5-alpha-reductase, alpha ... 14-alpha Demethylase Inhibitors. Cytochrome P-450 Enzyme Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... To determine if specific AR splice variations correlate with PFS in response to ketoconazole. ... To determine the presence of specific prostate cancer-associated gene translocations in each sample of CRPC. ...https://clinicaltrials.gov/ct2/show/NCT01275651?cond=%22Kennedy+disease%22&rank=60
IMP: Integrative Multi-species Prediction
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase). 0.844. ... SMAD specific E3 ubiquitin protein ligase 2. 0.987. Yeast AKR1C2. aldo-keto reductase family 1, member C2 (dihydrodiol ... dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III). 0.958. ... The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or ...http://imp.princeton.edu/predictions/process/human-context-global/4473/?gene=15690
BulkPharma :: Dihydrotestosterone-DHT | Buy Dihydrotestosterone-DHT Online
DHT is produced by males in utero and is responsible for the formation of male gender specific characteristics. DHT is also an ... Saw palmetto extract has been demonstrated to inhibit both isoforms of 5-alpha-reductase unlike finesteride which only inhibits ... Unlike most known 5-alpha-reductase inhibitors, saw palmetto induces its effects without interfering with the cellular capacity ... the (predominant) type 2 isoenzyme of 5-alpha-reductase. Also, the chemical equol, derived by consuming foods rich in soy ...https://bulkpharma.net/do.html?action=buy_steroids/dihydrotestosterone-DHT
Anti-DHRS9 antibody (ab98155) | Abcam
... alpha-hydroxysteroid dehydrogenase antibody. *3-alpha hydroxysteroid dehydrogenase antibody. *3-alpha-HSD antibody ... retinol dehydrogenase homolog antibody. *Retinol dehydrogenase, tracheobronchiol epithelail cell-specific antibody. *RETSDR8 ... 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone ... and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, ...http://www.abcam.com/dhrs9-antibody-ab98155.html
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as...
synthesis, 17 beta-hydroxysteroid dehydrogenase, type 3, inhibitors, cancer, nonsteroidal inhibitors, prostate-cancer, phenol, ... of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17[beta]- ... 5-alpha-reductase, acylation, strategy, series. Research Area:. Chemistry. Biological sciences. Faculty, School or Research ... by 3beta-hydroxysteroid dehydrogenase (3beta-HSD)]. The results of our study suggest that the synthesised compounds are, in ...http://eprints.kingston.ac.uk/7001/
Frontiers | Adult Hippocampal Neurogenesis Modulation by the Membrane-Associated Progesterone Receptor Family Member Neudesin |...
Hypoxanthine guanine phosphoribosyl transferase (Hprt), 5-alpha-reductase 2 and 3 gene (Srd5a2 and Srd5a3) and gamma- ... this effect is specific to the dorsal SGZ of the hippocampus. In accordance, we confirmed in vitro that neural stem cells ... 5-alpha-reductase 2 and 3 (Srd5a2 and Srd5a3) and gamma-aminobutyric acid A receptor, delta (Gabrd). ... The specific pattern of NENF expression and secretion by neurons suggests that it plays a role exclusively in neurons but not ...https://www.frontiersin.org/articles/10.3389/fncel.2018.00463/full
Frontiers | Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies | Endocrinology
These steroidogenic enzymes fall into two broad families: the cytochrome P450 (CYP) and hydroxysteroid dehydrogenase/ ... Mellon S, Bair S, Monis H. P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, ... cytochrome P450 17 alpha-hydroxylase, and 3 beta-hydroxysteroid-dehydrogenase messenger ribonucleic acid and proteins and on ... Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450. Proc Natl ...https://www.frontiersin.org/articles/10.3389/fendo.2016.00106/full
CAH Support Group Australia :: About CAH
The disorders are named after the specific hormone that is deficient: *21-hydroxylase deficiency (most common) ... 17-alpha-hydroxylase (very rare). What are the symptoms of CAH?. Female children who have severe CAH might be born with ...http://www.cah.org.au/education/about-cah/
The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
... β-hydroxysteroid dehydrogenase and to cause hepatotoxicity .(d)Turosteride, MK-434, and MK-963 inhibit mainly 5α-R2. MK-386 ... However, none of these trials studied the impact on disease-specific or overall survival and none compared 5α-RI mono- or ... β-hydroxysteroid dehydrogenase 2 and 10 (17β-HSD2 and 10) to DHT (the backdoor pathway to DHT synthesis). Androstandione is ... 5 Alpha Reduction: (5α-R1-3) [29, 30]. The substrates for 5α-reductases are 3-oxo (3-keto), Δ4,5 C 19/C21 steroids. The group " ...https://www.hindawi.com/journals/au/2012/530121/
Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid | Gut
Wehkamp J, Schwind B, Herrlinger KR, et al. Innate immunity and colonic inflammation: enhanced expression of epithelial alpha- ... Keratins 8, 19, and 20 as well as carbonic anhydrases (II, IV, VII) showed side specific expression and were downregulated in ... and NAD+ dependent 15 hydroxyprostaglandin dehydrogenase (PGDH; 16-fold) showed decreased expression. ... The existence of a side specific expression difference for COX-2, having been identified by microarray analysis and confirmed ...http://gut.bmj.com/content/54/3/374