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*  The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation...
... untranslated regions. AREs act as mRNA instability determinants but also confer stabilisation of the mRNA by the p38 pathway. ... The mRNAs regulated by p38 share common AU-rich elements (ARE) present in their 3'- ... untranslated regions. AREs act as mRNA instability determinants but also confer stabilisation of the mRNA by the p38 pathway. ... The mRNAs regulated by p38 share common AU-rich elements (ARE) present in their 3'- ...
https://www.kennedy.ox.ac.uk/publications/224221
*  Plus it
... untranslated regions (UTR), a single microRNA can regulate numerous target genes simultaneously, providing a mechanism for this ... miR-31 directly targets the 3'-UTR of the WAVE3 mRNA and inhibits its expression in the invasive cancer cells. The miR-31- ... Because of the high level of conservation of the target motifs, known as seed sequences, within the 3′- ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/2022
*  MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN | The Journal of Immunology
... untranslated region of PTEN, leading to the reduction of PTEN protein in bAMs. miR-26b also enhanced the LPS-induced NF-κB ...
http://www.jimmunol.org/content/early/2015/10/24/jimmunol.1402933
*  Antagomir - Wikipedia
... end of the untranslated region (UTR) of the mRNA strand, which adequately blocks microRNA from binding, as most microRNAs do ... not bind to the translated region. Antagomirs are used as a method to constitutively inhibit the activity of specific miRNAs. ...
https://en.wikipedia.org/wiki/Antagomir
*  HNRPD - Wikipedia
... untranslated region binds AUF1 and heat shock protein 27". J. Biol. Chem. 277 (49): 47061-72. doi:10.1074/jbc.M202272200. PMID ... 49 (3): 378-384. doi:10.1006/geno.1998.5237. PMID 9615222. "Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU- ... Tolnay M, Juang YT, Tsokos GC (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the ...
https://en.wikipedia.org/wiki/HNRPD
*  Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites | Science
Untranslated Regions and Fewer MicroRNA Target Sites. By Rickard Sandberg, Joel R. Neilson, Arup Sarma, Phillip A. Sharp, ... Untranslated Regions and Fewer MicroRNA Target Sites. By Rickard Sandberg, Joel R. Neilson, Arup Sarma, Phillip A. Sharp, ... Untranslated Regions and Fewer MicroRNA Target Sites ... Untranslated Regions and Fewer MicroRNA Target Sites. *Rickard ... regulatory regions, possibly because less control is required over RNA functions. ...
http://science.sciencemag.org/content/320/5883/1643.full
*  A variant in 3'-untranslated region of KRAS compromises its intera | COPD
... untranslated region (3'-UTR) of KRAS and let-7g, and its association with development of lung cancer in the patients with COPD. ... untranslated region of KRAS compromises its interaction with hsa-let-7g and contributes to the development of lung cancer in ... and that introduction of rs712 minor allele into 3'-UTR significantly compromised the miRNA/mRNA interaction by using a ... Our study demonstrated that KRAS 3'-UTR rs712 polymorphism interfered with miRNA/mRNA interaction, and showed that the minor ...
https://www.dovepress.com/a-variant-in-339-untranslated-region-of-kras-compromises-its-interacti-peer-reviewed-article-COPD
*  Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory...
... untranslated region of mRNA molecules specifying inflammatory mediators. D Caput, B Beutler, K Hartog, R Thayer, S Brown-Shimer ... untranslated region of mRNA molecules specifying inflammatory mediators. D Caput, B Beutler, K Hartog, R Thayer, S Brown-Shimer ... untranslated region of mRNA molecules specifying inflammatory mediators. D Caput, B Beutler, K Hartog, R Thayer, S Brown-Shimer ... untranslated region of mRNA molecules specifying inflammatory mediators Message Subject (Your Name) has sent you a message from ...
https://www.pnas.org/content/83/6/1670?ijkey=ebe0762bfc9938afbac6b91c124c4a463607a22d&keytype2=tf_ipsecsha
*  IGF-I 3' untranslated region: strain-specific polymorphisms and motifs regulating IGF-I in osteoblasts. | Sigma-Aldrich
... untranslated region: strain-specific polymorphisms and motifs regulating IGF-I in osteoblasts.. [Spenser S Smith, Catherine B ... untranslated region (UTR) is polymorphic between C3H and B6. Luciferase-Igf1 3' UTR reporter constructs showed that these ... The Igf1 coding region is nonpolymorphic, but its 3' ... polymorphic regions did not affect UTR function. IGF-I splice ... The Igf1 3' UTR encoded by exon 6 contains alternative polyadenylation sites. Proximal site use produces a short 3' UTR of ...
https://www.sigmaaldrich.com/catalog/papers/23183171
*  Hybrid 3untranslated regions suitable for efficient protein expression in mammalian cells - King Faisal Specialist Hospital &...
... regions which are composed of two regions, one region from an 3untranslated region of a stable eukaryotic mRNA, and an ... The present invention describes the use of hybrid short 3untranslated (3′UTR) ... Eukaryotic messenger RNA (mRNA) contains three regions, 5′ untranslated region (5′UTR), protein coding region, and 3′ ... untranslated region of a stable eukaryotic mRNA.. In a preferred embodiment, the first region or the two regions comprise the 3 ...
http://www.freepatentsonline.com/9017965.html
*  A 3′-Untranslated Region (3′UTR) Induces Organ Adhesion by Regulating miR-199a* Functions
Untranslated Region (3′UTR) Induces Organ Adhesion by Regulating miR-199a* Functions. Daniel Y. Lee,1,2 Tatiana Shatseva,1,2 ... untranslated region (3′UTR) of the target mRNAs, leading to translational repression [7]-[9]. By silencing various target mRNAs ... It is expected that there is no endogenous miRNA bind to this fragment as it is in the coding region. The PCR product was then ... 2008;3:e1719. [PMC free article] [PubMed]. 9. Hua Z, Lv Q, Ye W, Wong CK, Cai G, et al. MiRNA-directed regulation of VEGF and ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2638016/
*  A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of...
... untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA ... untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA ... untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA ... untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA ...
https://www.ncbi.nlm.nih.gov/pubmed/26554012
*  The biological basis for microRNA target restriction to the 3' untranslated region in mammalian mRNAs
... untranslated region in mammalian mRNAs. Shuo Gu,1 Lan Jin,1 Feijie Zhang,1 Peter Sarnow,2 and Mark A. Kay1 ... untranslated regions (3'UTR) of mRNAs to down-regulate their expression when the appropriate miRNA is bound to target mRNA. To ... These results show that while miRNA-mediated translational inhibition was limited to targets in the untranslated region, RNAi- ... Duursma AM, Kedde M, Schrier M, le Sage C, Agami R. miR-148 targets human DNMT3b protein coding region. Rna. 2008;14:872-7. [ ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2713750/
*  The 811 C/T polymorphism in the 3untranslated region of the selenoprotein 15-kDa (Sep15) gene and breast cancer in Caucasian...
... untranslated region (3′-UTR) contains two exclusively linked, polymorphic sites at positions 811 (C/T) and 1125 (G/A), which ... untranslated region of the human Sep15 gene. Cancer Res. 2001;61:2307-10.Google Scholar ... untranslated region of the selenoprotein 15-kDa (Sep15) gene and breast cancer in Caucasian women. ... 3.Department of Blood Group Serology and Transfusion MedicineMedical University of ViennaViennaAustria ...
https://link.springer.com/article/10.1007/s13277-015-3847-7
*  Regulation of gene expression for translation initiation factor eIF-2α: importance of the 3untranslated region | Biochemical...
... untranslated region. Suzanne MIYAMOTO, John A. CHIORINI, Elena URCELAY, Brian SAFER. Biochemical Journal May 01, 1996, 315 (3) ... These activities might be modulated by sequence elements contained within the untranslated regions of the eIF-2α gene. ... untranslated region (UTR) of eIF-2α, only two of which are normally utilized in human and mouse tissues. A functional role for ... Regulation of gene expression for translation initiation factor eIF-2α: importance of the 3untranslated region ...
http://www.biochemj.org/content/315/3/791
*  PLOS Genetics: Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved...
Complementary microRNA profiling revealed that shortened 3' UTRs are enriched for target sites of macrophage-expressed miRNAs, ... with systematic shifts towards increased cassette exon inclusion and shortening of Tandem 3' UTRs post-infection. These ... results therefore provide the first genome-wide empirical support for the idea that actively regulated shifts towards shorter 3 ... Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection ...
http://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1006338.g004
*  Variants in the 3'-untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma
... untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma Jin-Long Hu1 , Xin-Long Hu2, Chuang- ... untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma. J Cancer 2018; 9(20):3647-3650. doi: ... untranslated region (3′-UTR) of mRNAs of their target genes, resulting in mRNA cleavage or translation repression [9,10]. ... untranslated region (3'-UTR) may associate with gene expression by altering miRNAs binding. ...
http://jcancer.org/v09p3647.htm
*  The sequence and structure of the 3′-untranslated regions of chloroplast transcripts are important determinants of mRNA...
... untranslated regions of chloroplast transcripts are important determinants of mRNA accumulation and stability, Plant Molecular ... untranslated regions (3′ UTRs) of plastid mRNAs is an inverted repeat (IR) sequence that can fold into a stem-loop structure. ... untranslated regions (3′ UTRs) of plastid mRNAs is an inverted repeat (IR) sequence that can fold into a stem-loop structure. ... untranslated regions of chloroplast transcripts are important determinants of mRNA accumulation and stability. Rott, Ruth; ...
https://www.deepdyve.com/lp/springer_journal/the-sequence-and-structure-of-the-3-untranslated-regions-of-oqJREOfTQv
*  Molecular characterization of a foot-and-mouth disease virus containing a 57-nucleotide insertion in the 3untranslated region,...
... untranslated region, Archives of Virology" on DeepDyve, the largest online rental service for scholarly research with thousands ... "Molecular characterization of a foot-and-mouth disease virus containing a 57-nucleotide insertion in the 3′ ... Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB ... A region of the 5′ noncoding region of foot-and-mouth disease virus RNA directs efficient internal initiation of protein ...
https://www.deepdyve.com/lp/springer_journal/molecular-characterization-of-a-foot-and-mouth-disease-virus-JoMzYttVOE
*  The Role of CYP3A4 mRNA Transcript with Shortened 3′-Untranslated Region in Hepatocyte Differentiation, Liver Development, and...
However, in exon 13, a region with high-level reads followed by a region with low-level reads was found. A sharp decrease of ... untranslated region. bp. base pair(s). DMSO. dimethyl sulfoxide. FPKM. fragments per kilobase of exon per 106 fragments mapped ... Untranslated Region in Hepatocyte Differentiation, Liver Development, and Response to Drug Induction. Dan Li, Roger Gaedigk, ... untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci USA 106: ...
http://molpharm.aspetjournals.org/content/81/1/86.long
*  Microbiology Society Journals | Direct repeats in the 3untranslated regions of mosquito-borne flaviviruses: possible...
... untranslated region (3′UTR) of the three major mosquito-borne flavivirus (MBFV) subgroups, represented by Japanese encephalitis ... This 'robust alignment' approach demonstrated more extensive homologies in the 3′UTR than had been recognized previously and ... a method has been devised to construct and analyse a substantially improved 3′UTR alignment between these highly divergent ... viruses, based on the concept that deletions and/or insertions, in addition to substitutions, are important drivers of 3′UTR ...
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.82235-0
*  A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with...
... untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk. We therefore genotyped this single- ... untranslated region (UTR) of the gene [12, 13].. We hypothesize that polymorphisms in this gene could influence the risk of ... untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk. We therefore genotyped this single- ... untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1635
*  CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3Untranslated Region, Altering Polysome...
The region of the gel lane from the pulldown corresponding to ~20 kDa, as well as the corresponding region from a pulldown ... Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans. Jay Leipheimer, Amanda L. M ... Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans. Jay Leipheimer, Amanda L. M ... Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans. Jay Leipheimer, Amanda L. M ...
https://msphere.asm.org/content/3/4/e00201-18
*  Abstract A1: An miR‐502 binding site single‐nucleotide polymorphism in the 3′‐untranslated region of the SET8 gene is...
... untranslated region of the SET8 gene is associated with early age of breast cancer onset. Fengju Song, Hong Zheng, Ben Liu, ... untranslated region (UTR) of target genes. Single‐nucleotide polymorphisms of critical genes may affect their regulation by ... untranslated region of the SET8 gene is associated with early age of breast cancer onset ... untranslated region of the SET8 gene is associated with early age of breast cancer onset ...
http://cancerpreventionresearch.aacrjournals.org/content/3/1_Supplement/A1
*  Genetic Variation in the 3-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population - pdf...
Genetic Variation in the 3-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. . ... Genetic Variation in the 3-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. ... Genetic Variation in the 3-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population - ... 3, and male individuals per-allele OR = 0.730.62-0.87, P = 3.68×10−4. We further conducted a haplotype analysis and identified ...
http://libros.duhnnae.com/2017/jun9/14984726416-Genetic-Variation-in-the-3-Untranslated-Region-of-NBN-Gene-Is-Associated-with-Gastric-Cancer-Risk-in-a-Chinese-Population.php