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*  Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System | Circulation Research
Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res. 2003; 93: 280-291. ... Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene ... This Review is part of a thematic series on Cyclic GMP-Generating Enzymes and Cyclic GMP-Dependent Signaling, which includes ... Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile ...
http://circres.ahajournals.org/content/93/10/907.full
*  3',5'-cyclic-GMP phosphodiesterase - Wikipedia
... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ...
https://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase
*  Pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST. 933. Amino acid modifications. Feature key. Position(s). DescriptionActions ...
https://www.uniprot.org/uniprot/P0C1Q2
*  PDE6G - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Canis lupus familiaris (Dog) -...
... cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC. *cGMP binding Source: InterPro. View the complete GO annotation on ... cyclic phosphodiesterase subunit gammaAdd BLAST. 87. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... cyclic phosphodiesterase subunit gamma OS=Canis lupus familiaris OX=9615 GN=PDE6G PE=3 SV=1 ... p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and ...
http://www.uniprot.org/uniprot/P54827
*  Gentaur Molecular :GenWay \ Retinal rod rhodopsin-sensitive cGMP 3'.5'-cyclic phosphodiesterase subunit delta - EC 3.1.4.17;...
... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein \ 10-288-22226F for more molecular products ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein Related products : Retinal rod rhodopsin- ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein / Product Detail : 10-288-22226F Retinal rod ...
http://www.antibody-antibodies.com/product_det.php?id=1880995&supplier=search&name=Retinal%20rod%20rhodopsin_sensitive%20cGMP%203
*  Pde6g MGI Mouse Gene Detail - MGI:97526 - phosphodiesterase 6G, cGMP-specific, rod, gamma
J:32329 Tuteja N, et al., Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid ... 5 phenotypes from 1 allele in 1 genetic background 2 phenotypes from multigenic genotypes 18 phenotype references ...
http://www.informatics.jax.org/marker/MGI:97526
*  PDE6B Gene - GeneCards | PDE6B Protein | PDE6B Antibody
Phosphodiesterase 6B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Belongs to the cyclic nucleotide phosphodiesterase family.. Family:. * Belongs to the cyclic nucleotide phosphodiesterase ... GMP-PDE Beta 3 4 * EC 3.1.4.35 4 58 * PDEB 3 4 ... PDE6B (Phosphodiesterase 6B) is a Protein Coding gene. Diseases ... A novel mutation in exon 17 of the beta-subunit of rod phosphodiesterase in two RP sisters of a consanguineous family. (PMID: ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=PDE6B&keywords=GH04H000637&prefilter=genomic_location
*  Frontiers | AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and...
In addition, a clear therapeutic effect was present in mice treated at 2 weeks of age as well as in mice treated at 3 months of ... In addition, a clear therapeutic effect was present in mice treated at 2 weeks of age as well as in mice treated at 3 months of ... Specifically, we compare the influence of two different AAV vector capsids, AAV2/5 (Y719F) and AAV2/8 (Y733F), on restoration ... Specifically, we compare the influence of two different AAV vector capsids, AAV2/5 (Y719F) and AAV2/8 (Y733F), on restoration ...
https://www.frontiersin.org/articles/10.3389/fnins.2017.00292/full
*  Recombinant Human PDE6B 293 Cell Lysate PDE6B-3346HCL - Creative BioMart
GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit; CSNBAD2;. ... Antigen standard for phosphodiesterase 6B, cGMP-specific, rod, ... PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; ... This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading ... Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM ...
https://www.creativebiomart.net/description_405012_318.htm
*  Gene Info
... cyclic-GMP phosphodiesterase activity *[MF] calmodulin-dependent cyclic-nucleotide phosphodiesterase activity *[MF] hydrolase ... cyclic-AMP phosphodiesterase activity *[MF] cGMP binding *[MF] calcium- and calmodulin-regulated 3',5'- ...
https://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=40678&LLNO=18573
*  Recombinant Human PDE10A 293 Cell Lysate PDE10A-3355HCL - Creative BioMart
... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; nucleotide binding; ... phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677;. ... Antigen standard for phosphodiesterase 10A (PDE10A), transcript variant 2 is a lysate prepared from HEK293T cells transiently ... PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; ...
https://www.creativebiomart.net/description_405021_318.htm
*  tadalafil (CHEBI:71940)
... cyclic-GMP phosphodiesterase) inhibitor (CHEBI:71942) tadalafil (CHEBI:71940) has role vasodilator agent (CHEBI:35620) ... cyclic-GMP phosphodiesterase) inhibitor An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that blocks the action of 3',5'- ... A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name ... BENZO[1,3]DIOXOL-. 5-. YL-. 2-. METHYL-. 2,3,6,7,12,12A-. HEXAHYDRO-. PYRAZINO[1',2':1,6]PYRIDO[3,4-. B]INDOLE-. 1,4-. DIONE ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71940
*  urinary tract neoplasms benign drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Cyclic-GMP Phosphodiesterases / antagonists & inhibitors. Animals. Autonomic Nervous System / drug effects. Autonomic Nervous ... Chemical-registry-number] 0 / Actins; EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases; H2D2X058MU / Cyclic GMP ... MeSH-major] Cyclic GMP-Dependent Protein Kinases / metabolism. Prostate / enzymology. Prostatic Neoplasms / enzymology ... Immunohistochemical distribution of cyclic GMP-dependent protein kinase-1 in human prostate tissue. Eur Urol; 2007 Aug;52(2): ...
http://www.bmlsearch.com/?kwr=urinary+tract+neoplasms+benign+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
*  Phosphodiesterase 2 - Wikipedia
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs ... cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism" (PDF). Gen Physiol Biophys. 22 ... "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. Rev. 58 (3): 488-520. doi:10.1124/pr. ...
https://en.wikipedia.org/wiki/PDE2
*  Achromatopsia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
... cyclic-GMP phosphodiesterase activity. GO:0047555 9.46. PDE6C PDE6H 3. 3',5'-cyclic-nucleotide phosphodiesterase activity. GO: ... intracellular cyclic nucleotide activated cation channel activity. GO:0005221 9.32. CNGB1 CNGB3 ... Cyclic Nucleotide Gated Channel Beta 3. Protein Coding. 831.74. Pathogenic/Likely pathogenic 6 ... Cyclic Nucleotide Gated Channel Alpha 3. Protein Coding. 821.14. Pathogenic/Likely pathogenic 6 ...
https://www.malacards.org/card/achromatopsia
*  Overview: tpbB, Pseudomonas aeruginosa PAO1
YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa. ... Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in ... Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine ...
http://www.pseudomonas.com/feature/show?id=105008
*  Human Metabolome Database: Showing metabocard for Cyclic GMP (HMDB0001314)
Design and synthesis of xanthines and cyclic GMP analogs as potent inhibitors of PDE5. Phosphodiesterase Inhibitors (1996), 135 ... Cyclic GMP. Description. Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which ... cyclic nucleotide phosphodiesterase 1A. General function:. Involved in catalytic activity. Specific function:. Cyclic ... cyclic nucleotide phosphodiesterase 1B. General function:. Involved in catalytic activity. Specific function:. Cyclic ...
http://www.hmdb.ca/metabolites/HMDB0001314
*  Panoply™ Human PDE6B Knockdown Stable Cell Line - Creative Biogene
GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit; CSNBAD2; ... PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta [ Homo ... AAV Service Adenovirus Service Baculovirus Service GMP Grade Viral Service Herpes Simplex Virus (HSV) Service Lentivirus ... PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; ... 3,5-cyclic-GMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; ...
https://www.creative-biogene.com/Panoply-Human-PDE6B-Knockdown-Stable-Cell-Line-CSC-DC011510-1264529-14.html
*  PDE11A Antibody (NBP1-85919): Novus Biologicals
... cyclic-AMP and -GMP phosphodiesterase 11A. *EC 3.1.4. *EC 3.1.4.17 ... Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp ... cAMP and cGMP cyclic nucleotide phosphodiesterase 11A. *cAMP ...
https://www.novusbio.com/products/pde11a-antibody_nbp1-85919
*  SMART: Secondary literature for GAF domain
Bovine rhodopsin: amino acid substitutions Asp-83----Asn and Glu-134----Gln prevent activation of cyclic GMP phosphodiesterase. ... Extracts prepared from yeast expressing the human PDE2A3 hydrolyzed both cyclic AMP (cAMP) and cyclic GMP (cGMP). This activity ... but were completely unable to activate cyclic GMP phosphodiesterase. ... Human cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2A3) cDNAs were cloned from hippocampus and fetal ...
http://smart.embl.de/smart/show_secondary.cgi?domain=GAF
*  ASMscience | 26 Multispecies Interact
5-dihydroxy-2,3-pentanedione (DPD) was critical for maximal biofilm development. One site where natural multispecies biofilms ... Tischler, A. D., and, A. Camilli. 2004. Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation. Mol. ... Kirillina, O.,, J. D. Fetherston,, A. G. Bobrov,, J. Abney, and, R. D. Perry. 2004. HmsP, a putative phosphodiesterase, and ... Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic di-GMP. J. Bacteriol. 188:2681- ...
http://www.asmscience.org/content/book/10.1128/9781555815677.ch26
*  ASMscience | c-di-GMP and its Effects
3 ) that facilitate both in vivo and in vitro studies. Although it is commonly found as an environmental isolate, it is also an ... BifA, a cyclic-di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa ... Modulation of Pseudomonas aeruginosa biofilm dispersal by a cyclic-di-GMP phosphodiesterase with a putative hypoxia-sensing ... Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, ...
http://www.asmscience.org/content/book/10.1128/9781555817466.chap15
*  List of MeSH codes (D08) - Wikipedia
... cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 --- 3',5'-cyclic-nucleotide phosphodiesterase MeSH D08.811.277.352. ... cyclic gmp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.575 --- protamine kinase MeSH D08.811.913.696.620.682 ... cyclic-nucleotide phosphodiesterases MeSH D08.811.277.352.640.295 --- glycerophosphoinositol inositolphosphodiesterase MeSH ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 --- cyclic amp-dependent protein kinases ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Microbiology Society Journals | Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c
... aeruginosa PAO1 in a manner consistent with increased cyclic di-GMP production. Direct measurement of cyclic di-GMP levels by ... was cloned and expressed in Pseudomonas aeruginosa PAO1 to allow for assessment of cyclic di-GMP production and cyclic di-GMP- ... cyclic dimeric guanosine monophosphate (cyclic di-GMP), is involved in the control of multiple bacterial phenotypes, including ... The observed phenotypes and increased levels of cyclic di-GMP detected in P. aeruginosa expressing ml1419c could be abrogated ...
https://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000339
*  Natural Erectile Dysfunction Treatment - Pharmacological Sciences
... the cyclic nucleotide phosphodiesterases constitute a group of enzymes that catalyze the hydrolysis of various cyclic ... In the presence of a PDE5 inhibitor, nitrates cause profound increases in cyclic GMP and can dramatically reduce blood pressure ... Nitrovasodilators (see Chapter 31) produce vasodilation by NO-dependent elevation of cyclic GMP in vascular smooth muscle. The ... that hydrolyzes cyclic GMP to 5'GMP in the vasculature. Thus, coadministration of an NO donor (e.g., nitroglycerin) with a PDE5 ...
https://www.pharmacologicalsciences.us/erectile-dysfunction.html