The enzyme (3α-hydroxysteroid dehydrogenase : 3α-HSD) has been purified to homogeneity from pig adrenal cytosol by ammonium ... EGCG was then eluted within 20 min by using methanol-water-acetic acid (20 : 75 : 5 (v/v/v)) as an eluent. As an internal ... These results strongly suggest that 3α-HSD purified from pig adrenal cytosol is a bi-functional enzyme catalizing 3α- and 20α- ... Furthermore, the purified enzyme catalyzed not only 3α-reduction of 5α-DHT (9.65nmol/min/mg), but also catalized 20α-reduction ...
Aldosterone action is mediated by both mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Its ... Patients aged 20 years or older who had advanced HER2-positive gastric cancer and were refractory to trastuzumab, ...