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*  The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the | Beneficial Effects of RAF...
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the. The nucleoside analogues 8- ... Intro The book nucleoside analogues 8-amino-adenosine (8-NH2-Ado) and 8-chloro-adenosine (8-Cl-Ado) possess undergone extensive ... The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the ... and 8-chloro-adenosine but inadequate to induce level of resistance in delicate cells. Taken collectively, these results reveal ...
http://biodiversityhotspot.org/2017/08/the-nucleoside-analogues-8-amino-adenosine-and-8-chloro-adenosine-have-been-investigated-in-the/
*  2-Chloroadenosine (CADO) | Abcam
Buy 2-Chloroadenosine (CADO) (CAS 146-77-0), an adenosine receptor agonist. Join researchers using high quality 2- ... Effect of intraperitoneal and intrahippocampal (CA1) 2-chloroadenosine in amygdaloid kindled rats.. Brain Res 751:259-64 (1997 ...
http://www.abcam.com/2-chloroadenosine-cado-ab120037.html
*  2-chloroadenosine-5-triphosphate | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
2-chloroadenosine-5-triphosphate ligand page. Quantitative data and detailed annnotation of the targets of licensed and ...
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=1716
*  2-chloroadenosine-5-triphosphate | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
2-chloroadenosine-5-triphosphate ligand page. Quantitative data and detailed annnotation of the targets of licensed and ... 2R,3S,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate ...
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1716
*  Signal Transduction Reagents - Agonists - Alfa Aesar
|p|Agonists are substances that activate cellular receptor molecules to which they attach. In a nutshell, agonists bind to cellular receptors and elicit a biological response. The agonists enhance the signal transduction by binding to the receptor in cellular systems. They can be full agonists, activating the receptor to maximal activity, or partial agonists. There are also inverse agonists. These ligands bind receptors and cause the reverse biological response of the natural ligand. Alfa Aesar supplies receptor agonists for many different cellular protein receptors. These reagents include both natural receptor ligands as well as synthetic agonists. In addition, the conformational changes brought about by the agonists activate or increase the activation of secondary intracellular messenger.|/p|
https://www.alfa.com/en/signal-transduction-reagents-agonists/
*  Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20). | CureHunter
D-Ala2,D-Leu5]-enkephalin, which decreased cyclic AMP levels and reversed the 2-chloroadenosine-stimulated phosphorylation of ... NCB-20 cells were labeled with [32P]orthophosphate under conditions where 2-chloroadenosine gave maximum increases of 32P ...
http://www.curehunter.com/public/pubmed2450174.do
*  Adenosine, 2-chloro
InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15) ... Other names: Cl AS; 2 ClAdo; 2-Chloroadenosine; Cl-Ado; 2-chloroadenosinehemihydrate ... Adenosine, 2-chloro-. *Formula: C10H12ClN5O4 ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=146-77-0&Units=SI&cMS=on
*  Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents | BenthamScience
2-Chloroadenosine and Human Prostate Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry ...
http://www.eurekaselect.com/131510
*  Adenosine A3 Receptor Deficiency Exerts Unanticipated Protective Effects on the Pressure-Overloaded Left Ventricle | Circulation
Adenosine exerts multiple functions through activation of individual adenosine receptor subtypes.2-5 A1 receptors (A1R) and A3 ... Our finding that A3R KO attenuated the TAC-induced increase of COX-2 and tended to decrease TNF-α after TAC supports a role for ... Male C57BL/6 (Taconic, Germantown, NY) body weight-matched A3R KO mice2 (crossed back to Taconic C57BL/6 mice at least 16 times ... However, the A3R agonist 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (Cl-IB-MECA) or adenosine dose- and time- ...
http://circ.ahajournals.org/content/118/17/1713
*  Adenosine | Hello Bio
Buy low cost, high quality adenosine receptor tools from Hello Bio. A trusted, affordable life science reagent supplier. Up to 50% less than other suppliers.
https://www.hellobio.com/products/target/receptors-transporters/g-protein-coupled-receptors/adenosine.html
*  British Library EThOS: A neuropharmcological study of some aspects of carotid body chemoreceptor activity in the cat
It was found that intracarotid injections of adenosine: AMP; ADP; ATP; CoA;Me-adenosine analogues: N6-methyladenosine, 2- ... chloroadenosine, 3'-deoxyudenosine but not 2'-deoxyadenosine; cyclic AMP; dibutyryl cyclic AMP increased spontaneous ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.661090
*  Table of Contents - April 01, 1997, 281 (1) | Journal of Pharmacology and Experimental Therapeutics
Putative kappa-2 Opioid Agonists Are Antihyperalgesic in a Rat Model of Inflammation Janice Ho, Andrew J. Mannes, Ronald Dubner ... Somatostatin Inhibition of Acid and Histamine Release by Activation of Somatostatin Receptor Subtype 2 Receptors in Rats K. ... Identification of Insulin-Like Growth Factor Binding Protein-2 as a Biochemical Surrogate Marker for the in Vivo Effects of ... In Vivo Evidence for Carrier-Mediated Efflux Transport of 3′-Azido-3′-Deoxythymidine and 2′,3′-Dideoxyinosine Across the Blood- ...
http://jpet.aspetjournals.org/content/281/1
*  Transferable anticancer innate immunity in spontaneous regression/complete resistance mice | PNAS
2A). Fig. 2 B and C shows examples of PMN, MΦ, and NK surrounding S180 in rosettes. In contrast, CD8+ and CD4+ T cells and ... Tumor volume (V) was calculated by using the formula V = (W× W× L)/2, where W was the shorter of the two diameters and L was ... 2. Formation of leukocyte rosettes during the killing of cancer cells in SR/CR mice. SR/CR mice were challenged i.p. with 107 ... For PMN depletion, three i.p. injections of 500 μg of anti-Ly6G (10) were given to each SR/CR mouse at 2-day intervals. For NK ...
http://www.pnas.org/content/103/20/7753.full
*  Microcirculation and Mitochondrial Function in Focal Brain Ischemia | SpringerLink
Dora, E., 1985c, Effect of adenosine and its stabile analogue 2-chloroadenosine on cerebrocortical microcirculation and NAD/ ...
https://link.springer.com/chapter/10.1007/978-1-4684-5188-7_26
*  Streptomyces rishiriensis - Wikipedia
Charousová, Ivana; Javoreková, Soňa; Wink, Joachim (2 February 2015). "Isolation and characterization of Streptomyces ... Streptomyces rishiriensis produces coumermycin A1, notomycin, 2-chloroadenosine, phosphophenylalanarginine and lactonamycin. ...
https://en.wikipedia.org/wiki/Streptomyces_rishiriensis
*  Plus it
The adenosine analogs, 5'-N-ethylcarboxamidoadenosine (NECA) and 2-chloroadenosine (CAD) caused concentration-dependent ...
http://jpet.aspetjournals.org/content/251/3/943
*  Plus it
Transporter function was assessed by the site-specific binding of [3H]NBMPR and the cellular uptake of [3H]2-chloroadenosine. ...
http://molpharm.aspetjournals.org/content/early/2012/07/26/mol.112.079616
*  Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential...
2. Adenosine and 2-chloroadenosine also diminished the cyclic [3H]AMP-binding capacities, but did not affect the histone kinase ...
http://www.biochemj.org/content/194/2/621
*  ORBi: Browsing ORBi
However, this defect was not associated with an altered phosphorylation of the documented in vitro DUSP3 substrates, ERK1/2, ... However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of ... Thus, in contrast to TAp63 isotypes, we observed that DeltaNp63 proteins (alpha, beta, gamma) induce HbetaD1, 2 and 4 ... in Cell Metabolism (2014), 20(2), 280-94. The molecular mechanisms responsible for the failure of antiangiogenic therapies and ...
http://orbi.ulg.ac.be/browse?type=author&sort_by=1&order=DESC&rpp=20&etal=3&value=No%C3%ABl%2C+Agn%C3%A8s+p001977&offset=140
*  Plus it
Maximum increases of 2-4-fold were observed 0.5 min after addition of 10-40 µM adenosine. Smaller increases were obtained with ... In 0.5-min incubations 2-chloroadenosine was less effective than adenosine at concentrations below 20 µM and more effective at ...
http://molpharm.aspetjournals.org/content/11/5/528
*  Patente US5302384 - Endothelial-derived II-8 adhesion inhibitor - Google Patentes
B) Fura-2-loaded PMN (1 106 /ml) were suspended in 1.9 ml HBSS with Ca++ and Mg++. 100 μl aliquot of 20x concentrated IL-1 CM ( ... A) PMN (2 106 /ml) were resuspended in 1.9 ml HBSS was Ca++ and Mg++ (2 mill) and equilibrated with diSC3 -(5) (1.5 μM final ... In contrast, rIL-2 (100 U/ml), rIFN-γ (200 U/ml), and GM-CSF (200 U/ml) did not stimulate LAI production. In addition, the LAI ... 2). SHAM CM, to which rIL-1β (5 U/ml) was added after collection, had no inhibitory effect. Incubation of rIL-1β (5 U/ml)- ...
http://www.google.es/patents/US5302384?dq=flatulence
*  A ketogenic diet did not prevent effects on the ectonucleotidases pathway promoted by lithium-pilocarpine-induced status...
2.Departamento de Biologia Celular e Molecular, Faculdade de BiociênciasPontifícia Universidade Católica do Rio Grande do Sul ... Brain Res Mol Brain Res 114(2):140-145PubMedCrossRefGoogle Scholar ... Borowicz KK, Luszczki J, Czuczwar SJ (2002) 2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the ...
https://rd.springer.com/article/10.1007/s11011-012-9333-7
*  Adenosine receptor modulation of seizure susceptibility in rats
2-ClAdo-induced elevation of BIC seizure threshold was not antagonized by the benzodiazepine antagonists RO 15-1788 and CGS ... The rank order of potency for adenosine agonists to elevate PTZ seizure threshold was R-PIA , 2-ClAdo , NECA , CHA , S-PIA. R- ... This anticonvulsant action of 2-ClAdo and the proconvulsant effect of theophylline were observed with other chemoconvulsants ... The anticonvulsant action of 2-ClAdo was reversed by pretreatment with theophylline. Theophylline alone produced a ...
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/s7526g99n