g- 1, 6 NAKAO ISHIDA ETAL 3,334,022 NEOCARZINOSTATIN PRODUCED BY STREPTOMYCES CARZINOSTATICUS VAR NEOCARZINOSTATICUS Filed April 26, 1965 2 Sheets-Sheet 1 NAKAO ISHIDA KEIZO MIYAZAKI KATSUO KUMAGAI MITSUO RIKIMARU MA SAl-HKO KUROYA INVENTORS. B. SIMONTON & HERBERT W TAYLOR,JR. ATTORNEYS. NAKAO-ISHIDA ETAL NEOCARZINOSTATIN PRODUCED BY STREPTOMYCES Aug. l 1967 3,334,022 NOSTATICUS VAR. NEOCARZINOSIATICUS v CARZI Filed April 26, 1965 2 Sheets-Sheet O O O O O O O om D P a f P Om \r fl cm 09 PERCENT TRANSMISSION IUA IAR KGAW AA M WK W Y IKRO OO O UUH AO A QTT AEA NKKMM N w w 2% K ON N R IOYO M T ABIT H WA W RWR TMEK R BR CRRH Y B United States Patent 3,334,022 NEOCARZINOSTATIN PRODUCED BY STREPTOMYCES CARZIZVOSTATIC US VAR. NEOCARZINOSTATICUS Nakao Ishida, 90 Kakogoro-cho; Keizo Miyazaki, 48 Kakyoin-dori; Katsuo Kumagai, 129 Tori-cho; and Mitsuo Rikimaru, 61 Kita-shichiban-cho, all of Sendai, Japan; and Masahiko Kuroya, Room 605, Empire Corp., 28 Daikyo-machi, Shinjuku-ku, Tokyo, Japan Filed Apr. ...

1-(tert-Butyldimethylsilyl)oxy-3,3-bis(tributylstannyl)propene (5), a versatile gem-dimetallic allylic synthon accessible through various synthetic routes, has been condensed with (trimethylsilyl)propiolaldehyde to give the fully functionalised acyclic vinyltin compound 9h, which is a precursor of the complex dihydroxycyclopentene sub-unit of neocarzinostatin chromophore (NCS) 1. Subsequent transformation into the geminal (E)-alpha-chloro-(Z)-alpha-iodovinylic intermediate 20, followed by a palladium-catalysed carbometallation/cyclisation reaction including in situ trapping with either (tributylstannyl) acetylene or the more functionalised 3,3-diethoxy-1 1-(tributylstannyl) prop-1-yne delivered the corresponding alkyne-substituted 4-chloro-1,2-bis(silyloxy)cyclopent-3-enes 21 or 22, respectively. Chlorocyclopentene 21 was subsequently easily transformed into the target dienediyne adduct 23 by Sonogashira condensation with trimethylsilylacetylene. This diastereoselective process is efficient with only

DNA double-strand breaks (DSBs) containing unligatable termini are potent cytotoxic lesions leading to growth arrest or cell death. The Artemis nuclease and tyrosyl-DNA phosphodiesterase (TDP1) are each capable of resolving protruding 3′-phosphoglycolate (PG) termini of DNA double-strand breaks (DSBs). Consequently, a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3′-PG-terminated DSBs. Unexpectedly, however, a knockdown or knockout of TDP1 in Artemis-null cells did not confer any greater sensitivity than either deficiency alone, indicating a strict epistasis between TDP1 and Artemis. Moreover, a deficiency in Artemis, but not TDP1, resulted in a fraction of unrepaired DSBs, which were assessed as 53BP1 foci. Conversely, a deficiency in TDP1, but not Artemis, resulted in a dramatic increase in dicentric chromosomes following NCS treatment. An inhibitor of DNA-dependent protein kinase, a key regulator

Scientists from the University of Glasgow have discovered a safe and novel method that can safeguard important crops from the widespread bacterial disease Pseudomonas syringae (Ps). The results of their study are published in Plant Biotechnology Journal.. The researchers genetically modified (GM) plants to produce a protein antibiotic or bacteriocin throughout their lifetime. The bacteriocin is expressed by a harmless soil-living bacteria related to the Ps strain. The GM plants were then able to successfully defend themselves from bacterial infection without environmentally damaging effects.. Ps infects a wide range of crop species worldwide including tomato, kiwifruit, pepper, olive, soybeans, and fruit trees. Plant diseases result to massive economic losses, specifically around 15% of global crops annually (estimated worth of $150 billion), a third of which is due to bacterial diseases like Ps.. For more details, read the news release at the University of Glasgow website.. ...

Scientists from the University of Glasgow have discovered a safe and novel method that can safeguard important crops from the widespread bacterial disease Pseudomonas syringae (Ps). The results of their study are published in Plant Biotechnology Journal.. The researchers genetically modified (GM) plants to produce a protein antibiotic or bacteriocin throughout their lifetime. The bacteriocin is expressed by a harmless soil-living bacteria related to the Ps strain. The GM plants were then able to successfully defend themselves from bacterial infection without environmentally damaging effects.. Ps infects a wide range of crop species worldwide including tomato, kiwifruit, pepper, olive, soybeans, and fruit trees. Plant diseases result to massive economic losses, specifically around 15% of global crops annually (estimated worth of $150 billion), a third of which is due to bacterial diseases like Ps.. (Source: Crop Biotech Update, International Service for Acquisition of Agri-Biotech Applications. ...

Fingerprint Dive into the research topics of Discovery, characterisation and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa. Together they form a unique fingerprint. ...

To further understand the involvement of INT6 in DDR, we investigated whether the ATM kinase, essential for cellular signaling in response to DNA damage, was normally activated upon INT6 deficiency. First, the phosphorylation status of its substrate CHK2 was examined. As expected, irradiation of control siRNA-treated cells led to a rapid and optimal phosphorylation of CHK2 within 30 minutes after irradiation that significantly decreased by 2 hours (Fig. 2A). In contrast, INT6-depleted cells failed to show similar levels of increase at 30 minutes or at a later time point. This defect in CHK2 phosphorylation was not caused by a reduction in CHK2 protein levels (Fig. 2A). Phosphorylation of the checkpoint kinase CHK1 was also reduced in these cells (Fig. 2A). Activation of these 2 kinases was similarly impaired in cells depleted of INT6 by means of a short hairpin RNA (shRNA) and treated with the radiomimetic drug neocarzinostatin (Fig. 2B). The rescue of INT6 expression with an INT6 cDNA resistant ...

DNA damaging agents such as the antitumor drugs bleomycin and neocarzinostatin or those that generate oxygen radicals produce a variety of lesions in DNA. Amongst these is base-loss which forms apurinic/apyrimidinic (AP) sites or strand breaks with atypical 3termini. DNA repair at the AP sites is initiated by specific endonuclease cleavage of the phosphodiester backbone. Such endonucleases are also generally capable of removing blocking groups from the 3terminus of DNA strand breaks ...

Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA =, 2-hydroxy-5-methyl-1-naphthoate =, 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl- ...

Affiliation：Josai International University,薬学部,助手, Research Field：Medical pharmacy, Keywords：supernatural product,超天然物,バイオマーカー,遺伝子ライブラリー,antibody-like protein,neocarzinostatin,プロテオミクス,抗体様タンパク質,アミノ酸置換体,ファージディスプレイ, # of Research Projects：3, # of Research Products：3

Consultancy Services I can provide consultancy services related to bacteriocins and other similar protein antibiotics to both companies seeking to develop novel antibiotics and to potential investors in this technology. In addition, I have an excellent relationship with a long standing consultancy business specializing in traditional small molecule antibiotics that considerably broadens the available expertise. Examples of the areas where we are able to provide in-depth assistance include; For antibiotic developers ...

NCS Challenge Team Emeke raise over £800 for GAGA UK. Nine teenagers from Warwickshire joined GAGA UK on a community challenge event as part of their NCS summer experience.

I decided today, as I dried myself out, that Ive coined a new medical condition, NCS, New Car Syndrome. Symtoms that Im displaying include parking the car...

index.php/en/tab-panduan-terkini/1985-panduan-pelaksanaan-latihan-sldn-berasaskan-coptpa-dan-panduan-pelaksanaan-latihan-ncs-core-abilities-bagi-pb-sldn. ...

The twins and triplets club was formed in 1997 when a local Health Visitor recognised that there was a large number of multiple births but no local support for the mothers. Because of this she arranged for a room to be available within a Health Centre and invited mothers of multiple births to come along.. The club, which is run by local mums of twins and triplets, meets at Mossneuk Primary Community Wing in East Kilbride throughout the year on a Friday between 12 - 2pm. (The club is closed on some public holidays, please watch the website for any closure announcements) During the school term the club mums to be, babies, toddlers or pre-school children and during the school holidays children from multiples families of all ages are welcome. Siblings are very welcome too.. ...

What is in an article if its not read, appreciated or critically acclaimed. Going by the Group existence, this is a monthly acitivty initiated for wishful bloggers who can speak their mind on IM technology. Here is how to get followers and recommendation

15797213] The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. (Chem Biol. , 2005 ...

Nine-membered enediyne antitumor antibiotics C-1027, neocarzinostatin (NCS), and kedarcidin (KED) possess enediyne cores to which activity-modulating peripheral moieties are attached via (R)- or (S)-vicinal diols. We have previously shown that this stereochemical difference arises from hydrolysis of epoxide precursors by epoxide hydrolases (EHs) with different regioselectivities. The inverting EHs, such as SgcF, hydrolyze an (S)-epoxide substrate to yield an (R)-diol in C-1027 biosynthesis, whereas the retaining EHs, such as NcsF2 and KedF, hydrolyze an (S)-epoxide substrate to yield an (S)-diol in NCS and KED biosynthesis. We now report the characterization of a series of EH mutants and provide a predictive model for EH regioselectivity in the biosynthesis of the nine-membered enediyne antitumor antibiotics. A W236Y mutation in SgcF increased the retaining activity toward (S)-styrene oxide by 3-fold, and a W236Y/Q237M double mutation in SgcF, mimicking NcsF2 and KedF, resulted in a 20-fold ...

The Diversity of Bacteriocins in Gram-Negative Bacteria -- Molecular Evolution of Bacteriocins in Gram-Negative Bacteria -- The Diversity of Bacteriocins in Gram-Positive Bacteria -- Peptide and Protein Antibiotics from the Domain Archaea: Halocins and Sulfolobicins -- The Ecological and Evolutionary Dynamics of Model Bacteriocin Communities -- Bacteriocins Role in Bacterial Communication ...

Hi Ed, try using ncs_search.exclude_selection=None or ncs_search.exclude_selection=not all or ncs_search.exclude_selection=not ((chain A and resseq 1) or (chain B and resseq 1)) Note, by default it is: not ((chain A and resseq 1) or (chain B and resseq 1)) this is why it excludes your ligands. Pavel On 7/25/17 20:23, Edward A. Berry wrote: , Is it possible to restrain cartesian NCS for ligands in phenix.refine? , I included a ligand in an paired ncs-group and it seems to be omitted , from the , listing of those groups in the log file. , When I made an ncs_group including only ligands, it halted complaining , of empty selection. , Ed , _______________________________________________ , phenixbb mailing list , phenixbb at phenix-online.org , http://phenix-online.org/mailman/listinfo/phenixbb , Unsubscribe: phenixbb-leave at phenix-online.org ...

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

Suite 5, 3 Brodie-Hall Drive, Technology Park, Bentley WA 6102, Australia. For orders and quotations email: [email protected]. For accounts and administration email: [email protected]. For technical and other inquiries email: [email protected]. ...

Weight percent w/w, w/v, v/v % weight per weight (W/W), weight per volume (W/V), volume per volume (V/V) meanings and how to use it i ...

NCS delivers end-to-end ICT and communications engineering solutions to help governments and enterprises realise business value through the innovative use of technology.

Many people feel they should be able to cope on their own but, sometimes, this doesnt work: something that seemed relatively small and manageable can…

Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative approaches to antibiotic development are urgently required. Pyocins, produced by P. aeruginosa for intraspecies competition, are highly potent protein antibiotics known to actively translocate across the outer membrane of P. aeruginosa. Understanding and exploiting the mechanisms by which pyocins target, penetrate and kill P. aeruginosa is a promising approach to antibiotic development. In this work we show the therapeutic potential of a newly identified tRNase pyocin, pyocin SD2, by demonstrating its activity in vivo in a murine model of P. aeruginosa lung infection. In addition, we propose a mechanism of cell targeting and translocation for pyocin SD2 across the P. aeruginosa outer membrane. Pyocin SD2 is concentrated at the cell surface, via binding to the common polysaccharide antigen (CPA) of P. aeruginosa lipopolysaccharide (LPS), from where it can efficiently locate its outer

Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative approaches to antibiotic development are urgently required. Pyocins, produced by P. aeruginosa for intraspecies competition, are highly potent protein antibiotics known to actively translocate across the outer membrane of P. aeruginosa. Understanding and exploiting the mechanisms by which pyocins target, penetrate and kill P. aeruginosa is a promising approach to antibiotic development. In this work we show the therapeutic potential of a newly identified tRNase pyocin, pyocin SD2, by demonstrating its activity in vivo in a murine model of P. aeruginosa lung infection. In addition, we propose a mechanism of cell targeting and translocation for pyocin SD2 across the P. aeruginosa outer membrane. Pyocin SD2 is concentrated at the cell surface, via binding to the common polysaccharide antigen (CPA) of P. aeruginosa lipopolysaccharide (LPS), from where it can efficiently locate its ...

The translocation of protein toxins into a cell relies on a myriad of protein-protein interactions. One such group of toxins are enzymatic E colicins, protein antibiotics produced by Escherichia coli in times of stress. These proteins subvert ordinary nutrient uptake mechanisms to enter the cell and unleash nuclease activity. We, and others, have previously shown that uptake of ColE9 (colicin E9) is dependent on engagement of the OM (outer membrane) receptors BtuB and OmpF as well as recruitment of the periplasmic protein TolB, forming a large supramolecular complex. Intriguingly, colicins bind TolB using a natively disordered region to mimic the interaction of TolB with Pal (peptidoglycan-associated lipoprotein). This is thought to trigger OM instability and prime the system for translocation. Here, we review key interactions in the assembly of this colicin translocon and discuss the key role disorder plays in achieving uptake. ...

Iva Atanaskovic I am a first year student at the Department of Biochemistry in the Kleanthous Lab. I am co-supervised by Professor Martin Maiden, because my project will combine methods of biochemistry and bioinformatics. I am working on pyocins - protein antibiotics that target specific strains of a bacterium called Pseduomonas aeruginosa. The goal…

SynQuest specializes in all aspects of fluorine chemistry including fluoro aliphatics, fluorinated gases and fluoro aromatics. We have over 5200 chemicals in stock. What.s not in stock can be custom manufactured to your specifications. We supply quantities ranging from grams to multi-kilos. Try us today!

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

Our centre is equipped with two best digital EMG/NCS machines. We also assure the experience and expertise of our neurologists, for performing and reporting all kinds of neurological disorders.

Your email address and user information will only be used for the distribution of BrainWaves e-newsletters when new content is released on our site. You may choose to opt out of this free service at any time. There will be no spam!!. ...

Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since life on earth; more than 50% of existing cancer treatments is derived from plants. Bauhinia variegata is well-known medicinal plant used from the ancient era to till date for their medicinal values. Scientific literatures have not documented any evidence of the antitumour potential of Bauhinia variegata against B16F10 melanoma tumor model in C57BL mice. The present investigation was undertaken to explore the antitumour activity of Leaf, stem bark and flower extract of Bauhinia variegata against B16F10 melanoma tumour model in C57BL mice. Hydro-methanolic extract prepared from the leaf, stem bark and flower of Bauhinia variegata were assessed for their antitumor activity. The extracts at doses of 500 and 750 mg/kg b.wt. were given orally along with cyclophosphamide (chemotherapeutic drug) for 40 days

Fig. 1. Characterization of the NCS-induced DNA damage response in terms of cell viability and early induction of DSB sensors in ALS- and HC-hMSC populations. (A) The cells were treated with 50, 150, 300 and 500 ng/ml NCS for 30 min to induce DNA damage, rinsed and then kept in culture with fresh medium for 24 h. Cells were then fixed and the DNA damage response in terms of cell viability was quantified for the total number of nuclei using a living and dead fluorescence assay by staining the cells in microscopy-grade 96-well plates with a mix of Calcein-AM for live cells, propidium iodide (PI) for dead cells, and Hoechst 33342 to label all nuclei. Multiple images of thousands of cells were taken for image analysis of cell viability using the INCell 2000 image analyzer and software. Shown are mean±s.e.m. of a group of n=6 HC-hMSCs and n=6 ALS-hMSCs. For each individual, at least three independent experiments, where 10,000 cells were analyzed, were conducted. *P,0.05. (B-E) Cells were treated ...

1-Naphthoic acid (CAS 86-55-5) Market Research Report 2017 aims at providing comprehensive data on 1-naphthoic acid market globally and regionally (Europe,

Nepal Chemical Society (NCS) was built up in 1979 as a willful non-benefit relationship of all science experts of Nepal. NCS is submitted for making h...

The NCS2007x series operational amplifiers provide rail−to−rail output operation, 3 MHz bandwidth, and are available in single, dual, and quad configurations. Rail−to−rail operation enables the user to make optimal use of the entire supply voltage range. The NCS2007x can operate on supply voltages as low as 2.7 V up to 36V over the temperature range of −40°C to 125°C. At a 2.7 V supply, the high bandwidth provides a slew rate of 2.8 V/µs while only consuming 405 µA of quiescent current per channel. The wide supply range allows the NCS2007x to run on supply voltages as high as 36 V, making it ideal for a broad range of applications. Since this is a CMOS device, high input impedance and low bias currents make it ideal for interfacing to a wide variety of signal sensors. The NCS2007x devices are available in a variety of compact packages ...

The NCS have a stand at this event (stand A5) its free for health care professionals to attend. If we have any members who wish to attend but are not currently practicing please get in touch via [email protected] so that we can arrange a free place for you (free spaces are at the discretion of the organisers). Info about free spaces: http://www.primarycareandpublichealth.co.uk/visit/free-of-charge-attendance/ Link for booking: http://www.eventdata.co.uk/Forms/Default.aspx?FormRef=PCP57Visitor ...

NCS Paint Colour Matched 1K/2K 400ml Aerosol Spray Paint Can is professionally mixed by our team of coating experts using the very best ingredients.

Note: This does not work for hosted Wordpress sites. If you are running the Wordpress software, you will need the Embed Iframe plugin.. ...

Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP(7)), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7). In the present study, we show that mouse embryonic fibroblasts (MEFs) lacking IP6K1 exhibit impaired DNA damage repair via homologous recombination (HR). IP6K1 knock-out MEFs show decreased viability and reduced recovery after induction of DNA damage by the replication stress inducer, hydroxyurea, or the radiomimetic antibiotic, neocarzinostatin. Cells lacking IP6K1 arrest after genotoxic stress, and markers associated with DNA repair are recruited to DNA damage sites, indicating that HR repair is initiated in these cells. However, repair does not proceed to completion because these markers persist as nuclear foci long after drug removal. A fraction of IP6K1-deficient MEFs

3-HYDROXY-2-NAPHTHOIC ACID HYDRAZIDE 5341-58-2 NMR spectrum, 3-HYDROXY-2-NAPHTHOIC ACID HYDRAZIDE H-NMR spectral analysis, 3-HYDROXY-2-NAPHTHOIC ACID HYDRAZIDE C-NMR spectral analysis ect.

With NCS now capable of simulating networks of thousands of spiking neurons and many millions of synapses, students began to use it for actual research. NCS could be quite hard to use effectively in practice, however, as I discovered when I began my own first large-scale simulation experiments. Much of the difficulty in using NCS stemmed from the fact that NCS takes a plain-text file as input. This input file defines the characteristics of the neural network, including neuron and dendrite compartments, synapses, ion channels and more. For a large neural network model, this text file often grows to thousands or even hundreds of thousands of lines. Although this plain-text file approach allows a great deal of flexibility in model definition, it quickly becomes apparent to anyone doing serious work with NCS that it is not practical to create network models by directly editing the input file in a text editor. If the model contains more than a handful of neural structures, hand-editing is tedious and ...

A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

Our partnership with the NCS goes from strength to strength after educating over 900 young people on blood cancer and inspiring them to help raise awareness

Enhance your cycling experience with Bontrager NCS Fender Set. Find the best gear at trekbikes.com and your local Trek retailer. Shop now!

Our study provides new insights into mechanisms underlying the mitochondrial dysfunction in WFS1-deficient cells involving NCS1, a WFS1 interacting protein. We demonstrated that WFS1 interacted with the Ca2+ sensor NCS1 (39) and that NCS1 protein abundance was substantially decreased in WFS1-deficient cells. Addition of NCS1 to planar lipid bilayers or overexpression of NCS1 in PC12 cells results in increased IP3R channel activity (30-32), which should lead to increased Ca2+ release from the ER. In fibroblasts from our Wolfram syndrome patients, a decrease in Ca2+ flux from the ER was observed only under histamine application, whereas ER Ca2+ load was unchanged, suggesting a role of NCS1 in regulating IP3R activity. In addition, there was a concomitant decrease in the [Ca2+]m uptake. We further showed that ER-mitochondria structural interactions were reduced in patient cells, as evidenced by reduced interactions of two pairs of proteins at the MAM interface (VDAC1-IP3R1 and GRP75-IP3R1). This ...

lymph node,prefrontal cortex,H1-hESC,breast,appendix,HUVEC cell line,HSMM cell line,liver,salivary gland,HMEC cell line,gall bladder,MCF-7,adrenal gland,brain,HepG2,BJ,HeLa-S3,colon,placenta,NHLF cell line,adrenal,A549,SK-N-SH_RA,adipose tissue,ovary,stomach,kidney,pancreas,frontal lobe,cerebral cortex,skin,NHEK cell line,heart,prostate,animal ovary,lung,thyroid,testis,AG445,adipose,duodenum,bladder,spleen,endometrium ...

lymph node,prefrontal cortex,H1-hESC,breast,appendix,HUVEC cell line,HSMM cell line,liver,salivary gland,HMEC cell line,gall bladder,MCF-7,adrenal gland,brain,HepG2,BJ,HeLa-S3,colon,placenta,NHLF cell line,adrenal,A549,SK-N-SH_RA,adipose tissue,ovary,stomach,kidney,pancreas,frontal lobe,cerebral cortex,skin,NHEK cell line,heart,prostate,animal ovary,lung,thyroid,testis,AG445,adipose,duodenum,bladder,spleen,endometrium ...

This year North Carolina Swimming will recognize its Top Five swimmers, All Star swimmers, and Swimmers of the Year for the past three seasons; the 2011 Long Course season, the 2011-12 Short Course season, and the 2012 Long Course season. Here are the lists of those swimmers:. NCS 2011 LC Top Five-All Star Lists. NCS 2011-12 SC Top Five-All Star Lists. NCS 2012 LC Top Five-All Star Lists. The first column of each list includes all swimmers who were among the NC Top Five in any event in their respective double year age group (10U, 11-12, 13-14, 15-16, 17-18) in the final season rankings. The second column of each list includes those swimmers who have NC Top Five times in two different strokes, both of which must be AAAA times or better. The third column of each list includes those swimmers who have a USA Swimming Top Ten national time by individual age (11,12,13,14,15,16,17,18).. Those listed in the second and third columns are recognized as NCS All Stars. The Top Three male and Top Three female ...