Prevalence and associated factors of low serum zinc concentration in adolescents of Gambella city, Southwest Ethiopia Dedessa Gemeda Megersa,1 Solomon Mekonnen Abebe,2 Fikru Mekonnen Abebe,3 Molla Mesele Wassie2 1Department of Clinical Nursing, Gambella Teachers Education and Health Science College, Gambella, 2Human Nutrition Department, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, 3Department of Plant Science, College of Agriculture, Wollo University, Dessie, Ethiopia Background: Zinc deficiency is a major public health problem in many developing countries. It has been linked with reduced growth and development in adolescents. The deficiency increases vulnerability to infections, immune dysfunction, hypogonadism, and abnormal neurosensory changes. However, this problem has not received due attention, especially in Ethiopia. Therefore, this study is aimed to assess the prevalence and factors associated with low serum zinc concentration in high
TY - JOUR. T1 - Zinc deficiency in wheat genotypes grown in conventional and chelator-buffered nutrient solutions. AU - Rengel, Zed. PY - 1999. Y1 - 1999. N2 - Chelator-buffered nutrient solutions have been used extensively in studying plant-micronutrient relationships, but the effects of the chelator on plants are poorly understood. This study compared responses to Zn deficiency of two wheat genotypes (Triticum aestivum, cv. Aroona, and T. turgidum L. conv. durum, cv. Durati) grown in conventional and chelator-buffered nutrient solutions. With the same low activity of Zn2+ in both types of solution. shoot growth was impaired more and root exudation of phytosiderophores was greater in the chelator-buffered than in the conventional solution. Under Zn deficiency. Durati wheat (sensitive to Zn deficiency) suffered a greater level of inhibition of shoot growth and exuded less phytosiderophores from roots than Aroona a heat (tolerant to Zn deficiency). Under both Zn deficiency and Zn sufficiency, a ...
Evidence suggests that New Zealand (NZ) children are mildly zinc deficient and may respond to dietary change. A 20-wk randomized intervention trial was therefore conducted to determine whether an increased intake of red meat or consumption of a fortified manufactured toddler milk drink (FTMD, fortified with zinc and other micronutrients) would increase dietary zinc intakes and improve the biochemical zinc status of 12- to 20-mo-old NZ toddlers. Toddlers were randomized to a red meat intervention (n = 90), FTMD intervention (n = 45), or nonfortified milk placebo (n = 90). Study foods were provided. Adherence was assessed via monthly 7-d meat or milk recording diaries. Hair and serum zinc concentrations, and length and weight were measured at baseline and postintervention. Nutrient intakes were assessed via 3-d weighed food records at baseline, wk 4, and wk 18. At baseline, 38% of participants had low serum zinc concentrations despite seemingly adequate dietary zinc intakes (,4% below the ...
TY - JOUR. T1 - The influence of maternal zinc supplementation on immunological development of the neonate and perinatal morbidity. AU - Shankar, Anuraj. AU - Gbakima, Aiah. AU - Caulfield, Laura. AU - Zavaleta, Nelly. PY - 1998/3/20. Y1 - 1998/3/20. N2 - Gestational zinc deficiency (GZD)is increasingly being recognized as a significant problem affecting maternal health worldwide. In mice and non-human primates it has also been demonstrated that GZD has adverse and persistent effects on development of the immune system. We report here the effects in human beings of maternal zinc supplementation on immunological development of the neonate and on perinatal morbidity. In Lima, Peru, we conducted a double-blind placebo-controlled trial wherein 730 women were supplemented daily with 15 mg elemental zinc or placebo in conjunction with 60 mg iron and 200 ug folk acid. Cord blood plasma was obtained from children born of these women and the levels of IgM, IgA, IgG1, IgG2, IgG3, and IgG4 were determined. ...
Plasma concentrations of some micronutrients are altered in the setting of acute infectious or inflammatory stress. Previous studies have provided conflicting evidence concerning the extent and direction of changes in plasma zinc concentrations during the acute phase response. We carried out an observational cohort study in 689 children enrolled in a randomized trial of zinc supplementation during acute falciparum malaria in order to evaluate the relation between plasma zinc concentration and the acute phase response. Plasma zinc was measured by atomic absorption spectrophotometry. On admission, 70% of all subjects had low plasma zinc (|9.2 μmol/L). Multivariate analysis of predictors of admission plasma zinc showed that admission C-reactive protein (CRP), parasite density, and study site were the most important predictors. Predictors of changes in plasma zinc from admission to 72 h included baseline CRP, change in CRP, treatment group, study site, and baseline zinc concentration. In children with
Zinc Supplementation to Improve ADHD and Counteract Excess CopperElectromyogram (EMG) tests, which reflect brain activity, have objectively shown that low plasma zinc levels negatively affect information processing. 28 medication-free boys with ADHD, aged 7 to 12, were compared to 24 control children. Event-related potential indices from parietal and frontal brain regions showed that ADHD children had worse working memory (lower amplitudes of P3) and slower information processing (longer latency of P3) compared to control children. Individuals with ADHD and zinc levels ,80 μg/dL showed worse information processing and inhibition (shorter latencies of N2). Plasma zinc levels were significantly lower in ADHD individuals than in controls, but brain waves began to normalize with increasing plasma zinc levels (Yorbik et al., 2008).. Zinc supplements improve symptoms more than placebo and enhance the effectiveness of stimulant medications. When 400 ADHD children aged 6 to 14 were randomized to zinc ...
Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Forty-five rats were divided randomly into three groups: normal zinc diet (30 mg/kg), low zinc diet (10 mg/kg), and pair-fed diet(30 mg/kg). The concentrations of 16 minerals and trace elements in serum, feces, urine, and liver were measured by inductively coupled plasma mass spectrometry. The excretion of 16 elements in urine and feces were calculated and compared. Zinc-deficient rats exhibited significant changes in up to 12 minerals and trace elements. The low zinc diet induced decreased excretion of zinc and concentrations of zinc in serum, feces, urine, and liver. Zinc deficiency increased feces concentrations of Mg, Cu, Se, K, Ag, Fe and Mn; decreased the concentrations of Mg, Cu, Se, K in liver and urine, and a diminished amount of Ag was observed in serum.
The association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studies evaluating the association between serum zinc level and PE were included. The I2 was used to assess heterogeneity and the random effect model (REM) was adopted as the pooling method. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association between serum zinc level and PE. Seventeen observational studies were included. Compared with healthy pregnancy controls, PE patients have lower serum zinc level in 14 studies about total PE (SMD (95% CI): −0.587 (−0.963, −0.212), Z = 3.06, p for Z = 0.002; I2 = 88.4%, p for I2 < 0.0001). In subgroup analysis, a lower serum zinc level in PE patients compared with healthy pregnancy controls was observed in
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and neutrophil function. The study will be conducted on 30 adult patients aged grater than 18 years, of both genders who have undergone surgical resection of colonic neoplastic lesions without metastatic lesion. Patients will be randomized into two groups, with the first (Group QT Zn, n = 15) receive 70 mg/d of zinc for 16 weeks and the second will receive placebo (QT Placebo Group, n = 15). The study will also include 30 healthy volunteers who receive supplementation of 70 mg/d of Zn (C Zn group, n = 15) or placebo (Group C Placebo, n = 15). Zinc supplementation or placebo for all study groups will start two days before the volunteers received the pneumococcal vaccine, polyvalent 23. Fifteen days after vaccination, patients begin chemotherapy as pre-established criteria by the ...
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and neutrophil function. The study will be conducted on 30 adult patients aged grater than 18 years, of both genders who have undergone surgical resection of colonic neoplastic lesions without metastatic lesion. Patients will be randomized into two groups, with the first (Group QT Zn, n = 15) receive 70 mg/d of zinc for 16 weeks and the second will receive placebo (QT Placebo Group, n = 15). The study will also include 30 healthy volunteers who receive supplementation of 70 mg/d of Zn (C Zn group, n = 15) or placebo (Group C Placebo, n = 15). Zinc supplementation or placebo for all study groups will start two days before the volunteers received the pneumococcal vaccine, polyvalent 23. Fifteen days after vaccination, patients begin chemotherapy as pre-established criteria by the ...
Abstract: DESCRIPTION: Deficiency of zinc is prevalent in HAART and non-HAART treated HIV-1 seropositive males and female drug users and has been shown to have a profound impact on HIV disease status. Low levels of zinc are associated with an increased risk for HIV-1 related mortality, while increasing levels of plasma zinc are associated with slower disease progression. Other investigators have reported that zinc administration in HIV/AIDS patients stabilized weight, increased CD4 cell count, and reduced the number of opportunistic infections. As drug users are particularly susceptible to zinc deficiency (56 percent have low serum zinc levels), zinc therapy in HIV-1 infected drug users with low zinc levels (> 0.35 ug/ml and < 0.75ug/ml), is both timely and warranted. Originally the proposal was to randomize 210 participants into the two study arms but the revised application intends to use stratified randomization based on viral load to balance any potential impact of antiretroviral treatment ...
TY - JOUR. T1 - Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes. AU - Chung, Mi Ja. AU - Hogstrand, Christer. AU - Lee, Sung Joon. PY - 2006. Y1 - 2006. N2 - Metallothioneins (MTs) are small, cysteine-rich zinc binding proteins that are powerful antioxidants. In this study, we investigated the interaction between zinc, MTs, and other components of the antioxidant defense system in HepG2 cells. Cells were preincubated with zinc and then exposed to sodium nitroprusside (SNP), a nitric oxide (NO) donor. Both zinc pretreatment and SNP exposure separately induced transcription of MT genes (MT1A, MT2A, MT1E, MT1X), as measured using real time-polymerase chain reaction (PCR) after reverse transcription (RT). Pretreatment of HepG2 cells with zinc sulfate (ZnSO 4) followed by SNP exposure caused MT and glucose-6-phosphate dehydrogenase (G6PD) mRNA levels to increase more than in cells only exposed to SNP. However, when cells were incubated with ...
Increasing zinc (Zn) concentrations in crops is important for alleviation of human Zn deficiency. Arbuscular mycorrhizal fungi (AMF) contribute to plant Zn uptake, but their contribution to Zn in the edible portion of crops has not yet been investigated. This study aimed to quantify the mycorrhizal pathway of Zn uptake into grain of wheat and barley under varying soil Zn availabilities. Bread wheat (Triticum aestivum) and barley (Hordeum vulgare) were grown in pots with a hyphal compartment containing 65Zn. Plants were inoculated with Rhizophagus irregularis and grown at three soil Zn concentrations. Radioactive Zn in grain and straw was measured and the contribution of AMF to Zn uptake was calculated. The mycorrhizal pathway of Zn uptake contributed up to 24.3% of total above-ground Zn in wheat, and up to 12.7% of that Zn in barley. The greatest contribution by the mycorrhizal pathway was observed in barley at the lowest Zn addition, and in wheat at the highest one. In addition, grain yield of bread
One of the major functions of the metal response element-binding transcription factor 1(MTF-1) is to sense and maintain sub-nanomolar to nanomolar zinc levels in response to influxes of labile zinc within the cell. MTF-1 responses to elevated zinc include up regulation of metallothionein (MT-I & II) and efflux transporter (ZnT1) genes. MTF-1 also responds to oxidative stress and heavy metal loads. Due to a lack of liver development, MTF-1 is essential for embryogenesis as determined from knockout mice. The zinc dependence of DNA-binding and interactions with other transcription factors has been identified as major determinants in the homeostatic regulation of labile intracellular zinc by MTF-1. p300 along with its paralog, cyclic-AMP response element binding protein (CBP), have histone acetyltransferase protein scaffold functions and interact with other transcription factors. Previous studies have shown that p300, Sp1 and MTF-1 form a complex. It was also found that a zinc dependent interaction ...
Maternal plasma zinc concentrations and pregnancy outcome.: We conclude that plasma zinc concentrations during the late first trimester to the early third trime
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the leading cause of female cancer deaths. Zinc (Zn) functions as an antioxidant and plays a role in maintaining genomic stability. Zn deficiency results in oxidative DNA damage and increased cancer risk. Studies suggest an inverse association between dietary and plasma Zn levels and the risk for developing breast cancer. In contrast, breast tumor biopsies display significantly higher Zn levels compared with normal tissue. Zn accumulation in tumor tissue also correlates with increased levels of Zn importing proteins. Further, aberrant expression of Zn transporters in tumors correlates with malignancy, suggesting that altered metal homeostasis in the breast could contribute to malignant transformation and the severity of cancer. However, studies have yet to link dysregulated Zn transport and abnormal Zn-dependent functions in breast cancer development. Herein, we summarize studies that address the multi-modal role of Zn
Mechanisms through which gene expression is regulated by zinc are central to cellular zinc homoeostasis. In this context, evidence for the involvement of zinc dyshomoeostasis in the aetiology of diseases, including Type 2 diabetes, Alzheimers disease and cancer, highlights the importance of zinc-regulated gene expression. Mechanisms elucidated in bacteria and yeast provide examples of different possible modes of zinc-sensitive gene regulation, involving the zinc-regulated binding of transcriptional activators and repressors to gene promoter regions. A mammalian transcriptional regulatory mechanism that mediates zinc-induced transcriptional up-regulation, involving the transcription factor MTF1 (metal-response element-binding transcription factor 1), has been studied extensively. Gene responses in the opposite direction (reduced mRNA levels in response to increased zinc availability) have been observed in mammalian cells, but a specific transcriptional regulatory process responsible for such a ...
Among the first-line defense genes, ZRT1, ZRT2, and FET4 are induced by mild zinc deficiency to increase the ability of the cell to accumulate zinc from its environment. ZPS1 is also induced under these mild conditions and we have previously proposed that its product, a secreted protein related to metalloproteases, may also be involved in zinc acquisition by degrading extracellular proteins and releasing any bound metals [3]. Similarly, ZRT3 is up-regulated by mild zinc deficiency and also responds rapidly to zinc withdrawal. Thus, mobilization of zinc stores from the vacuole is also a first-line response. Induction of the YOR387C gene in response to mild zinc deficiency suggests that this gene is also involved in the first-line defense against zinc limitation. The function of this protein is not yet known but its pattern of regulation by zinc suggests that it may play a role in zinc uptake or vacuolar zinc export. TIS11 ( also known as CTH2) is also induced in LZM + 300 μM ZnCl2. Tis11 binds ...
PubMedID: 23039265 | Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes. | Autoimmunity | 2/1/2013
A new review of past studies suggests that taking zinc may cut the time adults have to suffer with a common cold, but the alternative treatment will likely come with unpleasant side effects.
What are zinc supplement health benefits are also such that you can increase it by having dairy products, eating wholegrain foods, lentils, pulses. Also even pumpkin is a very good source of zinc. Also zinc lozenges are easily available in drug stores which are mostly taken if you have cough or cold. What are zinc supplement health benefits is not a question to worry now so let me tell you what is the daily dose recommended for each person to be taken. For adults and teenage males it os preferred to be 9-12mg, pregnant women is to be 15mg, children from 1-10 years 3-9mg, and infants are preferred to take 2-3mg. So What are zinc supplement health benefits is now true. Also while seeing What are zinc supplement health benefits let me tell you that excess of anything is always harmful now this can be just anything. So excess of zinc in our body can prove to be fatal as it is toxic and reduces the function of iron and the iron levels in our body. So relating to What are zinc supplement health ...
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Intracellular zinc concentration and localization are strictly regulated by two main protein components, metallothioneins and membrane transporters. In mammalian cells, two membrane transporters family are involved in intracellular zinc homeostasis: the uptake transporters called SLC39 or Zip family and the efflux transporters called SLC30 or ZnT family. ZnT proteins are members of the cation diffusion facilitator (CDF) family of metal ion transporters. From genomic databanks analysis, we identified the full-length sequences of two novel SLC30 genes, SLC30A8 and SLC30A10, extending the SLC30 family to ten members. We used an expressed sequence tag (EST) data mining strategy to determine the pattern of ZnT genes expression in tissues. In silico results obtained for already studied ZnT sequences were compared to experimental data, previously published. We determined an overall good correlation with expression pattern obtained by RT-PCR or immunomethods, particularly for highly tissue specific genes. The
TY - GEN. T1 - Investigations in a child with hyperzincaemia: Partial characterisation of an abnormal zinc binding protein, kinetics and studies of liver pathology. AU - Sampson, B AU - Kovar, I Z AU - Beattie, J H AU - McArdle, H J AU - Rauscher, A AU - Fairweather-Tait, S J AU - Jasani, B PY - 1997. Y1 - 1997. KW - zinc. KW - zinc binding proteins. KW - liver. KW - growth disorders. M3 - Conference contribution. SN - 0-660-16404-3. SP - 484. EP - 486. BT - TRACE ELEMENTS IN MAN AND ANIMALS - 9. A2 - Fischer, PWF. A2 - Labbe, MR. A2 - Cockell, KA. A2 - Gibson, RS. PB - NATL RESEARCH COUNCIL CANADA. CY - OTTAWA. T2 - 9th International Symposium on Trace Elements in Man and Animals (TEMA 9). Y2 - 19 May 1996 through 24 May 1996. ER - ...
Poudel, an associate professor of community health education at UMass Amhersts School of Public Health and Health Sciences, with his colleagues epidemiologist Elizabeth Bertone-Johnson and Kalpana Poudel-Tandukar of the UMass Amherst College of Nursing, report in the current issue of Biological Trace Element Research that they observed a significant relationship between serum zinc concentration and serum C-reactive protein (CRP) concentration in HIV-positive individuals: higher zinc concentrations were associated with lower CRP levels.. CRP is a biomarker of inflammation that has been associated with several parameters of HIV disease progression and the focus of extensive epidemiologic investigation because it is also an independent survival predictor, Poudel says.. The fact that several studies have suggested that zinc might be something important for us to be aware of led us to analyze this micronutrient in HIV-positive patients, Poudel says. We hypothesized that lower concentrations of ...
Researchers recently studied the effects of daily 30 mg zinc supplementation for 3 months among nursing home residents to determine whether their serum zinc concentrations could improve. Their previous research had shown that around one-third of nursing home residents have low serum zinc levels and that these patients
1. To investigate the influence of hormonal conditions upon the kinetics of zinc transport, specific radioactivity of 65Zn was determined in certain tissues and fluids from unmated or pregnant rabbits during the first half of gestation. 2. Compartmental analysis was used to find the simplest mathematical model that simulated satisfactorily tracer behaviour. Models were fitted to experimental results by a numerical procedure using a computer. 3. The kinetics of zinc exchange in most tissues investigated could adequately be described by a three-compartment model, in which total tissue zinc content was divided into a rapidly exchanging pool, with a turnover time of about 1h, and a slowly exchanging pool, the turnover time of which was in liver 15h, in peak-stage corpus luteum 8h, and in the other tissues 30-70h. 4. In rabbit endometrium zinc transport varied with hormonal conditions, the turnover rate being higher in non-pregnant than pregnant endometrium. 5. Uptake of 65Zn by uterine fluid was ...
Public Release: 27-Jan-2016 Tufts University, Health Sciences Campus BOSTON (Jan. 27, 2016)--The immune system weakens as the body ages, making older adults more susceptible to infections. Low levels of zinc impair immunity, particularly in older adults. A research team set out to determine if it was feasible to increase serum zinc concentrations in older…
Rationale : Current knowledge on the relationship between seminal zinc levels and different parameters of human semen is inconsistent. Objectives : To assess the relationship between seminal plasma zinc and semen quality using two markers; zinc concentration (Zn-C) and total zinc per ejaculate (Zn-T). Design : The study was carried out as a cross-sectional study. Subjects and Methods : Semen parameters of 152 healthy men undergoing evaluation for subfertility were assessed. Seminal plasma zinc levels were determined using flame atomic absorption spectrometry. Zn-C, expressed as μg/mL, was multiplied by ejaculated volume to calculate Zn-T. Mann Whitney U test and Chi-square test were used to compare the zinc levels between different seminal groups when appropriate. Correlations were observed with Pearsons correlation of coefficient. Analysis was carried out using SPSS 10.0 for windows software. Results : Zn-C was low in 23 (15%) samples, while in 32 (21%) of the samples Zn-T was abnormal. The ...
There are a range of epidemiological studies that investigated the association between zinc exposure either through occupational activities or food supplementation and increased cancer risks. While no associations were found between occupational zinc exposure and excess cancer risk, the main association that has been made in this context is related to dietary/supplemental zinc and prostate cancer risk. In contrast to established clinical and experimental evidence that prostate cancer is associated with a decrease in the zinc uptake, numerous epidemiology studies and reports of the effect of dietary and supplemental zinc on the incidence of prostated cancer have provided divergent, inconsistent and inconclusive results which range from adverse effects of zinc, protective effects of zinc and no effect of zinc on the risk of prostate cancer. Clinical and experimental studies have established that zinc levels are decreased in prostate cancer and support a role of zinc as a tumor suppressor agent. ...
Plasma zinc concentrations during the first 2 years after diagnosis of insulin-dependent diabetes mellitus: a prospective study. ...
Zinc, like other neurotransmitters, has been shown to act as a transmembrane signal in neurons. Synaptically released zinc from presynaptic neurons enters the adjacent postsynaptic neurons and glial cells through voltage-gated zinc or calcium channels and functions as a cell-to-cell signaling modulator (Pan et al., 2011). Zinc has also been shown to be a novel second messenger for signal transduction (Yamasaki et al., 2007). To explore the mechanism by which zinc induces sperm activation, we compared the intracellular zinc distribution pattern before and after sperm activation using a membrane-permeable fluorescent probe of zinc, zinpyr-1 (Kd=0.7±0.1 nM). Surprisingly, we found that in non-activated spermatids zinc ions were highly enriched in vesicular structures even in the absence of the exogenous zinc (Fig. 2A). Labile zinc was also observed in the mitochondria in spermatids as indicated by the colocalization of zinpyr-1 and MitoTracker (Fig. 2A). Treatment with the zinc-specific chelator ...
Abstract. Approximately 10% of the U.S. population ingests ,50% of the current recommended daily allowance for zinc. We investigate the effect of zinc deficiency on DNA damage, expression of DNA-repair enzymes, and downstream signaling events in a cell-culture model. Low zinc inhibited cell growth of rat glioma C6 cells and increased oxidative stress. Low intracellular zinc increased DNA single-strand breaks (comet assay). Zinc-deficient C6 cells also exhibited an increase in the expression of the zinc-containing DNA-repair proteins p53 and apurinic endonuclease (APE). Repletion with zinc restored cell growth and reversed DNA damage. APE is a multifunctional protein that not only repairs DNA but also controls DNA-binding activity of many transcription factors that may be involved in cancer progression. The ability of the transcription factors p53, nuclear factor κB, and activator protein 1 (AP1) to bind to consensus DNA sequences was decreased markedly with zinc deficiency, as assayed by ...
Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters and diet. A case-control study was performed in a group of adolescents with Down syndrome (n = 30) and a control group (n = 32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition. The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes, and 24-h urinary zinc excretion, by using the method of atomic absorption spectroscopy. The diet of both groups presented adequate concentrations of lipids, proteins, ...
Last update on 2020-03-30 / Links & Images from Amazon Product Advertising API. Zinc is an essential trace element and it doesnt take a lot to help maintain optimal health. In fact, the National Institutes of Health recommends only 11 mg and 8 mg of Zinc respectively for males and females. Moreover, its also rare to experience severe Zinc deficiency as most diets already have more than enough Zinc.. On the other hand, mild Zinc deficiency is quite common for the general population and interestingly, it happens mostly because of inadequate Zinc intake. As one study suggests, 25% of the worlds population is at risk of zinc deficiency - and thats a conservative estimate. That being said, Zinc is notably good for the immune system and lack of Zinc typically results in immune related symptoms.. However, since Zinc is a component of more than 300 enzymes and an even greater number of other proteins (as per a 2010 study), lack of this mineral also inevitably causes emasculating side effects ...
Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation. Zinc deficiency has adverse consequences during embryogenesis and early childhood development, particularly on immune functioning. It is essential in members of all enzyme classes, including over 300 signaling molecules and transcription factors. Free zinc in immune and tumor cells is regulated by 14 distinct zinc importers (ZIP) and transporters (ZNT1-8). Zinc depletion induces cell death via apoptosis (or necrosis if apoptotic pathways are blocked) while sufficient zinc levels allows maintenance of autophagy. Cancer cells have upregulated zinc importers, and frequently increased zinc levels, which allow them to survive. Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor
Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model (FIAM) is well-established in the literature, and shows that just micromolar amounts of the free ion kills some organisms. A recent example showed 6 micromolar killing 93% of all daphnia in water.[4] Swallowing a post 1982 American one cent piece (97.5% zinc) can also cause damage to the stomach lining due to the high solubility of the zinc ion in the acidic stomach.[5] Zinc toxicity, mostly in the form of the ingestion of US pennies minted after 1982, is commonly fatal in dogs where it causes a severe hemolytic anemia.[6] In pet parrots zinc is highly toxic and poisoning can often be fatal[7]. There is evidence of induced copper deficiency at low intakes of 100-300 mg Zn/d. The USDA RDA is 15 mg Zn/d. ...
Thirty-four HIV/AIDS patients at various stages of disease progression volunteered to manage their health using a nutritional supplement that contained several micronutrients that included a 15 nig daily dose of elemental zinc. This initial publication only focuses on trends in the serum zinc levels and the observed biochemical changes following intervention, considering the critical role this trace element plays in human immunity. At baseline and after 30 months of follow-up, the patients serum zinc levels were determined as was their clinical status. Four women who were found to be HIV negative at baseline and who had lost their husbands to HIV/AIDS, yet they had regularly had un-protected sex with them, had a mean serum zinc level of 116.2 ± 32.7 meg/100 ml. The serum zinc levels of asymptomatic, moderately symptomatic and severely symptomatic HIV/AIDS patients in the cohort reduced from baseline to post intervention levels of 92.5+12.1 to 78.0 + 8.2 meg/100 ml (P = 0.056); 81.9+ 17.6 to ...
And lastly, should you get a zinc blood test … Trace minerals are a group of tests that measure specific minerals, mostly in the blood, but at times in the urine or another body tissue or fluid. Zinc is vital for the proper functioning of the skin, brain, central nervous system, immune system, gastrointestinal tract, musculoskeletal system, reproductive system, and more. Common symptoms include increased rates of diarrhea. Symptoms Of Zinc Deficiency - Impaired Brain Functions. Zinc deficiency needs to be identified prior to treating it. To find out if there is zinc deficiency in the body, try the so-called tasting test at home. Quite deficient: no immediate taste is noticed but, within the ten seconds of the test, a … If the liquid seems sweet and has a pleasant taste to you, or it seems like ordinary water - it means that the body needs more Zn. Clinical test for Zinc deficiency, transient neonatal offered by Laboratorio de Genetica Clinica SL Zinc tolerance test. A normal serum zinc level ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a decrease in the serum concentration is only detectable after long-term or severe depletion, serum zinc is not a reliable biomarker for zinc status. Common symptoms include increased rates of diarrhea, pneumonia, and malaria.[citation needed] Zinc deficiency affects the skin and gastrointestinal tract; and the central nervous, immune, skeletal, and reproductive systems. Zinc deficiency in humans is caused by reduced dietary intake, inadequate absorption, increased loss, or increased body system utilization. The most common cause is reduced dietary intake. In the U.S., the Recommended Dietary Allowance (RDA) is 8 mg/day for women and 11 mg/day for men. Zinc plays an essential role in numerous biochemical pathways. The highest concentration of dietary zinc is found in oysters, meat, beans, and nuts. Increasing the amount of zinc in the soil and thus ...
In a report, the effect of delivery mode (cesarean section or vaginal delivery) was studied on maternal and newborn Mg and Zn blood serum levels. While maternal Mg and Zn levels did not differ before delivery, the plasma Zn level significantly decreased in women who underwent vaginal delivery, relative to the zinc levels of women with caesarean section. This is probably due to the high stress of skeletal muscles and uterine muscles during childbirth. In another study, plasma zinc levels lower than average were associated with complications during pregnancy and during labor and delivery.6, 7. ...
According to the reference(1), concentration of total Zn in root of wheat seedlings cytoplasm can be 0.4mM (i.e. about 25mg/L). However, based on a widely used recipe of plant growing medium -- Murashige and Skoog salt(2), Zn concentration at 0.03 mM (1.95mg/L of Zn2+) will be enough for many kinds of plants. I am not sure what plant your are testing and what the environment you are applying on the plant, both would influence your experimental result. But generally speaking, plant in 0.1mg/l solution would probably show one or several Zn deficiency symptoms, like: young leaves growth reduction; leaf margin distorted or puckered; light sensitive and interveinel choloroses in leaves; retardation of stem growth(3). However I did not find reference about the effects of excessive Zn for plant, probably because in nature, the problem for plants is deficiency of Zn rather than excess of it. I would like to know your experimental results, especially the one about 100mg/L Zn. About the function of Zn, ...
TEXTBOOKS. McGrath JA, Bleck O. Acrodermatitis Enteropathica. In: NORD Guide to Rare Disorders. Lippincott Williams & Wilkins. Philadelphia, PA. 2003:94.. REVIEW ARTICLES. Chimienti F, Aouffen M, Favier A, et al. Zinc homeostasis-regulating proteins: new drug targets for triggering cell fate. Curr Drug Targets. 2003;4:323-38.. Perafan-Riveros C, Franca LF, Alves AC, et al. Acrodermatitis enteropathica: case report and review of the literature. Pediatr Dermatol. 2002;19:426-31.. Bleck O, McGrath JA, South AP. Searching for candidate genes in the new millennium. Clin Exp Dermatol. 2001;26:279-83.. Sehgal VN, Jain S. Acrodermatitis enteropathica. Clin Dermatol. 2000;18:745-48.. Fraker PJ, King LE, Laakko T, et al. The dynamic link between the integrity of the immune system and zinc status. J Nutr. 2000;130(5S Suppl):1399S-406S.. JOURNAL ARTICLES. de la Fuente-García A, Liy-Wong C, Küry S, Schmitt S, Jamall IS, Ocampo-Candiani Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a ...
Filteau, S M. and Woodward, B, The effect of severe protein deficiency on serum zinc concentration of mice fed a requirement level or a very high level of dietary zinc. (1982). Subject Strain Bibliography 1982. 3299 ...
Author Summary Loss-of-function of the zinc transporter ZIP4 in the mouse intestine mimics the lethal human disease acrodermatitis enteropathica. This is a rare disease in humans that is not well understood. Our studies demonstrate the paramount importance of ZIP4 in the intestine in this disease and reveal that a root cause of lethality is disruption of the intestine stem cell niche and impaired function of the small intestine. This, in turn, leads to dramatic weight loss and death unless treated with exogenous zinc.
Indian Journal of Basic and Applied Medical Research; December 2013: Vol.-3, Issue-1 , 80-87 Original article : Effect of acute myocardial infarction on serum zinc level * DR. PRAVIN P. SHEKOKAR 1, DR. MRS. S. D. KAUNDINYA2 1Assistant Professor, Department of Physiology, Government Medical College, Akola, Collector Office Road, Akola. Pin 444001 (Maharashtra), India 2Professor & Head of Dept, Department of Physiology, Grant Government Medical College And Sir J.J. Hospital, Mumbai-8, India *Corrersponding author : Email: [email protected] Abstract: Introduction: Myocardial infarction is a common presentation of coronary artery disease. The diagnosis of acute myocardial infarction (AMI) is of vital importance from the management and prognosis point of view. Objective: The purpose of this study was to investigate serum zinc level in acute myocardial infarction patients and to correlate it with biochemical parameter SGOT. Methods: In the present study 30 patients suffering from acute myocardial ...
Zinc has low toxicity, but high zinc levels from water stored in galvanized containers interfere with iron and copper metabolism. Wound healing is impaired with moderate zinc deficiency and is improved by zinc supplements. Impaired taste and smell, hair loss and night blindness are also features of severe zinc deficiency.. ...
The present study examines serum zinc concentrations in patients with chronic fatigue syndrome (CFS) versus normal volunteers. Serum zinc levels were determined by means of an atomic absorption method. We found that serum zinc was significantly lower in the CFS patients than in the normal controls. There was a trend toward a significant negative correlation between serum zinc and the severity of CFS and there was a significant and negative correlation between serum zinc and the subjective experience of infection. We found that serum zinc was significantly and negatively correlated to the increase in the alpha2 protein fraction and positively correlated to decreases in the expression of mitogen-induced CD69+ (a T cell activation marker) on CD3+ as well as CD3+CD8+ T cells. These results show that CFS is accompanied by a low serum zinc status and that the latter is related to signs of inflammation and defects in early T cell activation pathways. Since zinc is a strong anti-oxidant, the present ...
zinc-binding protein: found in human milk; absence in cows milk implicated as cause of infant acrodermatitis (severe zinc deficiency); found in rat sperm tail
Acrodermatitis enteropathica is a rare inherited form of zinc deficiency, characterized by periorificial and acral dermatitis, alopecia, and diarrhea. .
Background: Previous work has implicated accumulation of Zn2+ as a contributor to ischemic brain injury, however the sources of toxic Zn2+ accumulation are not fully understood. Previous data report that ICV delivery of a Zn2+ chelator limited mild focal stroke (Neuroscience 115 (2002) 871-8). We have recently demonstrated substantial synaptic Zn2+ release following spreading depolarization (JCBFM 31 (2011) 1073-84), and thus it is possible that repetitive spreading depolarization_ known to occur following stroke_ could be a major source of toxic Zn2+. In the present study, we examined whether synaptic Zn2+ release contributes to neuronal injury in a murine focal stroke model.. Methods The effect of synaptic Zn2+ was assessed using mice lacking synaptic Zn2+, due to genetic deletion of the synaptic vesicle transporter ZnT3 (ZnT3 KO). Wild type C57Bl/6 mice were age and sex matched as controls. Mice were anesthetized with isofluorane and the cortical branch of the right middle cerebral artery was ...
TY - JOUR. T1 - The tonoplast-localized transporter OsHMA3 plays an important role in maintaining Zn homeostasis in rice. AU - Cai, Hongmei. AU - Huang, Sheng. AU - Che, Jing. AU - Yamaji, Naoki. AU - Ma, Jian Feng. N1 - Funding Information: This work was supported by a Grant-in-Aid for Specially Promoted Research (JSPS KAKENHI grant no. 16H06296 to JFM). We also acknowledge the National Key Research and Development Program of Funding Information: China (2016YFD0200108) and the China Scholarship Council for funding this work. Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.. PY - 2019/5. Y1 - 2019/5. N2 - In order to respond to fluctuating zinc (Zn) in the environment, plants must have a system to control Zn homeostasis. However, how plants maintain an appropriate level of Zn during their growth and development is still poorly understood. In this study, we found that OsHMA3, a tonoplast-localized transporter ...
TY - JOUR. T1 - Alterations in the chemotactic and respiratory burst responses of peripheral blood neutrophils from zinc deficient rats. AU - Sakanashi, T. M.. AU - Keen, Carl L. AU - Hong, K. H.. AU - Gershwin, M. Eric. AU - Fletcher, M. P.. PY - 1995. Y1 - 1995. N2 - Studies of polymorphonuclear leukocyte (PMN) functions in small animals have primarily been limited to elicited peritoneal PMNs. We have developed a model of induced acute inflammation in rats that provides a means of studying the functions of circulating PMNs. Using this model, we studied the influence of zinc deficiency on the chemotactic and respiratory burst capabilities of circulating PMNs responding to an inflammatory stimuli. Male rats were fed a zinc deficient (Zn-D) diet (0.5 μg Zn/g) or a control diet (25 μg Zn/g) either ad libitum (C) or in restricted amounts (R-C) for 6 weeks. PMNs were elicited by an intraperitoneal injection of glycogen and the circulating PMN response monitored for 4 h. The kinetics of peripheral ...
A brief summary of the research carried out on the problem of geophagia is reported in this paper. Geophagia was a common finding among Turkish children and women in villages, associated with severe iron deficiency anemia in addition to zinc depletion. The syndrome characterized by geophagia, iron deficiency anemia, growth retardation, hypogonadism and zinc deficiency has been observed in both sexes in Turkey for several decades. Zinc deficiency has been also shown by our group in this syndrome. The decreased concentrations of zinc in serum, plasma, RBC, hair and urine were measured by atomic absorption spectrophotometer. Oral iron (both inorganic and radioactive iron) and zinc absorption tests were carried out with and without clay and revealed decreased iron and zinc absorption in some cases with prolonged geophagia. Therefore, malabsorption of iron and zinc was considered to be an additional and/or a new finding in the syndrome. Furthermore, Turkish clay most probably inhibits zinc absorption in a
Interaction between nanoparticles generated by zinc chloride treatment and oxidative responses in rat liver Inès Azzouz, Hamdi Trabelsi, Amel Hanini, Soumaya Ferchichi, Olfa Tebourbi, Mohsen Sakly, Hafedh AbdelmelekLaboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, TunisiaAbstract: The aim of the present study was to investigate the interaction of zinc chloride (3 mg/kg, intraperitoneally [ip]) in rat liver in terms of the biosynthesis of nanoparticles. Zinc treatment increased zinc content in rat liver. Analysis of fluorescence revealed the presence of red fluorescence in the liver following zinc treatment. Interestingly, the co-exposure to zinc (3 mg/kg, ip) and selenium (0.20 mg/L, per os [by mouth]) led to a higher intensity of red fluorescence compared to zinc-treated rats. In addition, X-ray diffraction measurements carried out on liver fractions of zinc-treated rats point to the biosynthesis of zinc sulfide and/or selenide nanocomplexes at nearly 51
Abstract Background Zinc plays important roles in maintaining normal function of the prostate and in development of prostate malignancy. It has been demonstrated that prostate malignant epithelial cells contain much less cellular zinc than the surrounding normal epithelial cells. However, the pathway(s) which leads to lower zinc accumulation in malignant prostate epithelial cells is poorly understood. In this study, the zinc homeostatic features of two human prostate epithelial cell lines (non-tumorigenic, RWPE1, and tumorigenic, RWPE2) were investigated. Effects of over-expression of ZIP1 in RWPE2 on cell proliferation and apoptosis were also studied. Results RWPE2 accumulated less intracellular zinc than RWPE1 due to the decreased zinc uptake activity. The mRNA expression of ZIP1 and ZIP3 in RWPE1 and RWPE2 was comparable. However, the protein expression of ZIP1 in RWPE2 was lower than that in RWPE1. ZIP3 was detected in a lysosomal compartment of RWPE2 while no ZIP3 was detected in the same
Zinc affects both non-specific and specific immune functions. In terms of non-specific immunity, it affects the integrity of epithelial barrier and function of neutrophils, monocytes and macrophages. With regard to specific immunity, both lymphopenia and declined lymphocyte function occur in zinc deficiency. Although most of these effects are derived from experimental animals, studies in human subjects have also shown that altered zinc status can affect immune competence. For example, elderly subjects who received supplemental zinc demonstrated improvement in delayed cutaneous hypersensitivity, number of circulating T cells and serum IgG antibody response to tetanus toxoid. In other studies of experimentally induced mild zinc deficiency among adults, a reduction in serum thymulin and specific subpopulations of lymphocytes occurred during zinc depletion, and these returned to normal levels following zinc repletion. Although specific links between altered immunity and different infections are not ...
Some evidence suggests zinc may be helpful for age related macular degeneration, as an appetite stimulant, to help with bad breath, helps boils, burns, and cancer sores (indeed many skin conditions), and helps with cancer prevention and chemotherapy side effects. Zinc seems to help anything involving brain function or lack of it, serious diseases like celiac, cystic fibrosis, Downs syndrome, or any disorder affecting the immune system, including HIV, malaria, and parasitic infections. Diabetics have better blood sugar control with adequate zinc intake, and it can reduce nerve pain. Zinc supplementation has shown improved HDL to LDL ratios, improves thyroid function, helps inflammatory bowel disease and can improve kidney and liver function. Zinc seems to be important in reducing symptoms of inflammation, like rheumatic diseases, psoriasis, and vaginitis to name a few. Zinc may be effective for the treatment of warts. SYMPTOMS OF DEFICIENCY. Although zinc deficiency wasnt recognized until 1961, ...
Zinc (Zn2+) plays a pivotal role in many fundamental cellular processes. Zinc homeostasis is coordinated by zinc import, export and distribution. Both free and chelated zinc are stored in different intracellular spaces, forming a dynamic pool of coordination and interactions. Some selectively targeted genetically encoded sensors revealed the heterogeneous distribution of zinc in the cytoplasm, nucleus and most organelles, including the endoplas-mic reticulum, Golgi apparatus and mitochondria [1, 2]. Compared to other cell types, pancreatic beta cells contain exceptionally high zinc content; specifically, the insulin-storing vesicle may contain up to 70% of the total beta-cell zinc, the major stored form of which is zinc-insulin crystals with a molecular ratio of 2:6 [3]. By quantitative electron probe microanalysis of thin, dried cryosec-tions of individual secretory vesicles, Foster and his colleagues found that the beta-cell zinc concentration in dense-core vesicles reached the 10-2 mol/L ...
The yeast Saccharomyces cerevisiae is the best known microorganism and therefore widely used in many branches of industry. This study aims to investigate the accumulation of three inorganic zinc salts. Our research presents the ability of this yeast to absorb zinc from liquid medium and such enriched biomass use as a potential source of microelements in animal and/or human nutrition. It was found that the addition of different zinc forms, i.e. zinc nitrate, zinc sulphate and zinc chloride in fixed concentrations of 0, 25, 50 and 100 mg.100 ml-1 did not affect the amount of dry yeast biomass yielded, i.e. 1.0 - 1.2 g of yeast cells from 100 ml of cultivation medium, while higher presence of zinc solutions caused significantly lower yield of yeast biomass. The highest amount of zinc in yeast cells was achieved when added in the form of zinc nitrate in concentration of 200 mg.100 ml-1 YPD medium. The increment of intracellular zinc was up to 18.5 mg.g-1 of yeast biomass ...
Zinc (Zn) deficiency associated with low dietary intake is a well-documented public health problem, resulting in serious health and socioeconomic problems. Field experiments were conducted with wheat to test the role of both soil and foliar application of ZnSO4 in Zn concentration of whole grain and grain fractions (e.g., bran, embryo and endosperm) in 3 locations. Foliar application of ZnSO4 was realized at different growth stages (e.g., stem elongation, boot, milk, dough stages) to study the effect of timing of foliar Zn application on grain Zn concentration. The rate of foliar Zn application at each growth stage was 4 kg of ZnSO4·7H2O ha-1. Laser ablation (LA)-ICP-MS was used to follow the localization of Zn within grain. Soil Zn application at a rate of 50 kg of ZnSO4·7H2O ha-1 was effective in increasing grain Zn concentration in the Zn-deficient location, but not in the locations without soil Zn deficiency. In all locations, foliar application of Zn significantly increased Zn ...
Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution. In particular, current knowledge on human intestinal zinc absorption and the influence of diet-derived factors on bioaccessibility and bioavailability as well as intrinsic luminal and basolateral factors with an impact on zinc uptake are discussed. Their investigation is increasingly performed using in vitro cellular intestinal models, which are continually being refined and keep gaining importance for studying zinc uptake and transport via the human intestinal epithelium. The vast majority of these models is based on the human intestinal cell line Caco-2 in combination with other relevant components of the intestinal epithelium, such as mucin-secreting goblet cells and in vitro digestion models, and applying improved compositions of apical and basolateral media to mimic the in ...
Zinc is an essential trace element for humans and plays a critical role both as a structural component of proteins and as a cofactor in about 300 enzymes. Zinc deficiency was, for example, reported to affect the immune response and the endocrine system and to induce and modify brain disorders. Besides hereditary zinc deficiency, zinc deficiency - at least in mild forms - is nowadays a very abundant health issue. Today, an estimated 20% of the population worldwide is at risk of developing zinc deficiency with a high number also in industrialized countries. The major risk factors to develop zinc deficiency in industrialized nations are aging and pregnancy. Mechanistic and behavioral studies on the effects of zinc deficiency have mainly been performed using animal models. However, in combination with the few studies on human subjects, a picture emerges that shows importance of adequate nutritional zinc supply for many processes in the body. Especially the immune system and brain development and function
The yeast ADR1 protein contains two zinc finger domains that are essential for its role in transcriptional activation of alcohol dehydrogenase (ADH2). These domains are thought to function as DNA-binding structures. An ADR1-beta-galactosidase fusion protein made in Escherichia coli and containing the finger domains of ADR1 binds in vitro in a zinc-dependent manner to DNA fragments containing the two ADH2 upstream activation sequences. The strongest binding is to upstream activation sequence 1, a 22-base-pair palindrome. ...
Despite a growing body of evidence implicating T-channels in nociception (Todorovic et al., 2001; Bourinet et al., 2005; Choi et al., 2007), the cellular and molecular basis of their function in nociceptors is poorly understood. In the present study, we demonstrated that reducing agents sensitize nociceptors both in vitro and in vivo in a manner that is dependent on Cav3.2. In current-clamp experiments on acutely dissociated rat DRG neurons, we show that l-cys lowers the threshold for excitability in C-type cells that express Cav3.2 currents but not in C-type cells expressing only HVA Ca2+ currents. Furthermore, we show that a similar form of sensitization is present in Cav3.2 current-containing, C-type nociceptors from wild-type mice but not from Cav3.2−/− mice. Additionally, we demonstrated that reducing agents induce thermal sensitization when injected into peripheral receptive fields in vivo, in which putative Cav3.2 channels are located on nociceptor endings. Importantly, this ...
Despite a growing body of evidence implicating T-channels in nociception (Todorovic et al., 2001; Bourinet et al., 2005; Choi et al., 2007), the cellular and molecular basis of their function in nociceptors is poorly understood. In the present study, we demonstrated that reducing agents sensitize nociceptors both in vitro and in vivo in a manner that is dependent on Cav3.2. In current-clamp experiments on acutely dissociated rat DRG neurons, we show that l-cys lowers the threshold for excitability in C-type cells that express Cav3.2 currents but not in C-type cells expressing only HVA Ca2+ currents. Furthermore, we show that a similar form of sensitization is present in Cav3.2 current-containing, C-type nociceptors from wild-type mice but not from Cav3.2−/− mice. Additionally, we demonstrated that reducing agents induce thermal sensitization when injected into peripheral receptive fields in vivo, in which putative Cav3.2 channels are located on nociceptor endings. Importantly, this ...
Selan Plus Zinc Oxide with NDC 0159-2200 is a a human over the counter drug product labeled by Trividia Manufacturing Solutions, Inc. The generic name of Selan Plus Zinc Oxide is selan plus zinc oxide.
Eseja: Classificaion of Scandium and Zinc are not transitional metal base on their general chemistry and properties. Introduction The three series of elements s
Mucolipidosis type IV (MLIV) is caused by loss of function mutations in the TRPML1 ion channel. We previously reported that tissue zinc levels in MLIV were abnormally elevated; however, the mechanism behind this pathologic accumulation remains unknown. Here, we identify transmembrane (TMEM)-163 prot …
178 patients were treated with zinc sulphate, 3x200mg p.o. for 6 months whilst 129 patients received a placebo. Both groups were comparable in terms of duration of disease (diameter 3,7 yrs), extent of alopecia (diameter 52% of the scalp) and age at first manifestation of the disease (diameter 28, 5 yrs). However the number of atopic patients was higher in the placebo group (45%) rather than the zinc treated group (35%). After 6 months the data of 108 of the zinc-treated patients and 83 of the placebo group were analysed. The zinc-treated group showed an overall response of 44%, complete remission in 13% and partial remission in 31% of cases. The control group showed complete remission in 4% and partial remission in 19% of cases. The authors also noted an even greater beneficial effect in the treated group for those patients whose alopecia was of shorter duration and more limited in extent. They recommended a trial with zinc treatment in such cases ...
D4185-17 Standard Test Method for Measurement of Metals in Workplace Atmospheres by Flame Atomic Absorption Spectrophotometry trace metals content~ sample collection~ flame atomic absorption spectrophotometry~
Celiac disease (CD) is apparently changing in its clinical presentation, from chronic diarrhea and malnutrition to a silent clinic at older ages. The basal enteropathy of CD induces macro-and micronutrient malabsorption. Described micronutrient deficiencies in CD include: Fe, Zn, Cu, folate, Ca, vitamin E, D, B12 and B6, with complex transporter mechanisms altered. Ferropenic anemia has been described in CD as the exclusive sign and the most common extraintestinal sign. Zn deficiency is frequent in CD, associated with growth delay and immune alterations. Even though the main basis for vitamin D metabolic status is the activation of subdermal vitamin precursors by sun-UVB rays, the small bowel compromise may affect activity and vitamin D absorption. Pathophysiology of vitamin B12 deficiency in CD is unknown; it must be suspected in CD patients presenting neurological and haematological alterations. Copper deficiency has been described mainly in adult CD patients. Micronutrient deficiencies should be
Deficiency in zinc can occur due to not getting enough zinc through our food and not being able to absorb zinc properly because of poor gut health. Symptoms of zinc deficiency can manifest themselves in negative reactions like fatigue, frequently falling ill, stunted growth, poor concentration, and inability to heal wounds.. The highest levels of zinc are found in foods high in protein. Vegan and vegetarian diets are at a higher risk of zinc deficiency since both diets are naturally lower in zinc than diets that include protein from animal sources. However, plant-based diets can still meet zinc requirements through a variety of zinc sources. Plant-based rich sources of zinc are grains, beans & legumes, raw cacao, nuts & seeds, nutritional yeast, and oats. Keep in mind when consuming grains, beans, and legumes, as these also contain phytates which block zinc absorption. Thus, it is necessary to soak these before cooking and consuming them.. If you are an individual that has a leaky gut, suffer ...
To evaluate the physiological responses of wheat to zinc (Zn) fertilizer application under drought stress, pot and field experiments were conducted on wheat plants grown under different soil moistures and treated with soil and foliar Zn applications. Photosynthetic characteristics, antioxidant content, Zn element concentration and the transcription level of genes involved in antioxidant biosynthesis were analyzed. Zn application increased SPAD and Fv/Fm of wheat flag leaves, while decreased lipid peroxidation levels and H2O2 content. Zn application increased the antioxidant content (ascorbate, reduced glutathione, total phenolic and total flavonoid) of wheat flag leaves, and enhanced the relative expression levels of two antioxidant enzyme genes, four ascorbate-glutathione cycle genes, and two flavonoid biosynthesis pathway genes under drought stress. Soil Zn application increased grain yield and Zn concentration by 10.5% and 15.8%, 22.6% and 9.7%, and 28.2% and 32.8% under adequate water supply,
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1. The effect of erythropoietin and some trace elements on superoxide dismutase (SOD) activity of dialysis patients have been studied. 2. SOD activity of dialysis patients was found to be decreased. 3. The effect of erythropoietin on SOD activity was not found in vitro. 4. Plasma and erythrocyte aluminum increased in dialysis patients, but no significant change in plasma copper was found. 5. Plasma zinc levels of dialysis patients were found to be decreased. 6. These results suggest that inhibition of erythrocyte SOD activity of dialysis patients may contribute to their anemia. ...
Poligrip Zinc-free denture adhesive is available from online sellers including Amazon.com. According to Poligrip, there has recently been a shortage in stores due to difficulty getting their active...
Acid-sensing ion channel 1b (ASIC1b) is a proton-gated Na(+) channel mostly expressed in peripheral sensory neurons. To date, the functional significance of ASIC1b in these cells is unclear due to the lack of a specific inhibitor/blocker. A better understanding of the regulation of ASIC1b may provid …
An individuals zinc status has a significant impact on the immune system, and zinc deficiency, as well as supplementation, modulates immune function. To investigate the effects of zinc on different leukocyte subsets, we used microarray technology to analyze and compare the changes in mRNA expression in cell culture models of monocytes (THP-1), T cells (Jurkat), and B cells (Raji), in response to supplementation for 40 h with 50 µM zinc or 2.5 µM of the membrane-permeant zinc chelator TPEN [N,N,N′,N′- tetrakis-(2-pyridyl-methyl)ethylenediamine], respectively. In each cell type, several hundred genes were identified to be zinc sensitive, but only a total of seven genes were commonly regulated in all three cell lines. The majority of those genes were involved in zinc homeostasis, and none in immune function. Nevertheless, further analysis revealed that zinc affects entire functional networks of genes that are related to proinflammatory cytokines and cellular survival. Although the zinc-regulated
Despite the known importance of zinc for human immunity, molecular insights into its roles have remained limited. Here we report a novel autosomal recessive disease characterized by absent B cells, agammaglobulinemia and early onset infections in five unrelated families. The immunodeficiency results from hypomorphic mutations of SLC39A7, which encodes the endoplasmic reticulum-to-cytoplasm zinc transporter ZIP7. Using CRISPR-Cas9 mutagenesis we have precisely modeled ZIP7 deficiency in mice. Homozygosity for a null allele caused embryonic death, but hypomorphic alleles reproduced the block in B cell development seen in patients. B cells from mutant mice exhibited a diminished concentration of cytoplasmic free zinc, increased phosphatase activity and decreased phosphorylation of signaling molecules downstream of the pre-B cell and B cell receptors. Our findings highlight a specific role for cytosolic Zn(2+) in modulating B cell receptor signal strength and positive selection.
Participants (n = 20) ranged from 19-44 years old; 52% were black or African American. Among those completing the trial (13/17, PC-1005; 3/3, placebo), 11/17 reported liking the gel overall; 7 recommended reducing the volume. Adverse events, which were primarily mild and/or unrelated, were comparable between groups. Low systemic MIV-150 levels were observed, without accumulation. Plasma zinc levels were unchanged from baseline. Seven of seven CVLs collected 4-hour postdose demonstrated antiviral (HIV, human papillomavirus) activity. High baseline CVL anti-herpes-simplex virus type-2 (HSV-2) activity precluded assessment of postdose activity.. CONCLUSIONS ...
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Zinc deficiency is usually due to insufficient dietary intake, but can be associated with malabsorption, acrodermatitis enteropathica, chronic liver disease, chronic renal disease, sickle cell disease, diabetes, malignancy, and other chronic illnesses.[10] Groups at risk of zinc deficiency include the elderly, children in developing countries, and those with renal dysfunction. In the United States, a federal survey of food consumption determined that for women and men over the age of 19, average consumption was 9.7 and 14.2 mg/day, respectively. For women, 17% consumed less than the EAR, for men 11%. The percentages below EAR increased with age.[206] The most recent published update of the survey (NHANES 2013-2014) reported lower averages - 9.3 and 13.2 mg/day - again with intake decreasing with age.[207]. Symptoms of mild zinc deficiency are diverse.[208] Clinical outcomes include depressed growth, diarrhea, impotence and delayed sexual maturation, alopecia, eye and skin lesions, impaired ...
Two series of Zn-ZSM-5 catalysts were prepared by ion exchanging two commercial zeolites with different Si/Al ratios (40 and 15) with increasing Zn loadings. The nature of the Zn sites in the zeolite was studied by spectroscopy using laboratory and synchrotron techniques. All the evidences suggest that catalytic activity is associated with [Zn(H2O)n(OH)]+ species located in the exchange positions of the materials with little or no contribution of ZnO or metallic Zn. The effect of Zn/Al ratio on their catalytic performance in methanol conversion to aromatics has been investigated. In all cases, higher Zn content causes an increase in the yield of aromatics while keeping the production of alkanes low. For similar Zn contents, high densities of Al sites favour the hydrogen transfer reactions and alkane formation whereas in samples with low Al contents, and thus higher Zn/Al ratio, the dehydrogenation reactions in which molecular hydrogen is released are favoured ...
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The yeast, Saccharomyces cerevisiae requires certain elements for the growth and development of healthy cultures. The divalent cation, zinc is of paramount importance to this yeast, as zinc is a structurally and functionally essential metal that cannot be replaced by any other element. Zinc accumulation by S. cerevisiae is a biphasic response, consisting of a rapid metabolism independent and a metabolism dependent phase. Metabolism-independent metal ion accumulation is a physical process, whereby the ions are associated with the cell wall. This stage of uptake is often referred to as biosorption and zinc uptake is influenced by temperature, pH, biomass concentration and the presence of competing ions. The second phase of zinc uptake (metabolism-dependent metal ion accumulation) concerns the intracellular accumulation of the ions. This biological accumulation, often abbreviated to bioaccumulation, is slower than biosorption as the zinc ions are transported into the cell, via the plasma membrane ...
In this open-label clinical study, 72 patients in various stages of AMD received a daily supplement of 50 mg zinc sulphate and 1 mg cupric sulphate for three months. During the course of the study, six venous blood samples were collected. One sample was collected prior to zinc supplementation and served as the baseline sample. Three samples were collected at the end of months 1, 2 and 3 of the three-month period of zinc supplementation. To check for any reversible effects of zinc on complement activation we collected a two blood sample after ending the zinc administration. From one month prior to zinc supplementation through the end of month 5, the patients were prohibited to take any type of other nutritional supplement. All patients were genotype for the CFH variant Y402H (rs1061170) and ARMS2 (A69S; rs10490924). We performed color fundus photography and spectral domain optical coherence tomography to assist AMD grading based on the 5-grade Clinical Age-Related Maculopathy Staging ...
Highly effective antiviral treatment can suppress HIV-1 infection, but the chronic effects of HIV-1-related viral proteins, including gp120 and Tat, on organs such as the lungs can be damaging. HIV-1 transgenic rodent models are useful for studying the systemic effects of these proteins independently of viral infection. We have previously shown that HIV-1 transgene expression (and therefore, HIV-1-related protein expression) in rats decreases alveolar macrophage zinc levels and phagocytic capacity by unknown mechanisms. We hypothesized that HIV-1 transgene expression induces chronic inflammation and zinc sequestration within the liver and thereby decreases zinc bioavailability in the lung. We examined the expression of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα), the zinc storage protein, metallothionein (MT1), and the zinc exporter, ZNT1 in the livers and the lungs of wild type and HIV-1 transgenic rats ± dietary zinc supplementation. In addition, we measured zinc levels, the
Highly effective antiviral treatment can suppress HIV-1 infection, but the chronic effects of HIV-1-related viral proteins, including gp120 and Tat, on organs such as the lungs can be damaging. HIV-1 transgenic rodent models are useful for studying the systemic effects of these proteins independently of viral infection. We have previously shown that HIV-1 transgene expression (and therefore, HIV-1-related protein expression) in rats decreases alveolar macrophage zinc levels and phagocytic capacity by unknown mechanisms. We hypothesized that HIV-1 transgene expression induces chronic inflammation and zinc sequestration within the liver and thereby decreases zinc bioavailability in the lung. We examined the expression of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα), the zinc storage protein, metallothionein (MT1), and the zinc exporter, ZNT1 in the livers and the lungs of wild type and HIV-1 transgenic rats ± dietary zinc supplementation. In addition, we measured zinc levels, the