Prevalence and associated factors of low serum zinc concentration in adolescents of Gambella city, Southwest Ethiopia Dedessa Gemeda Megersa,1 Solomon Mekonnen Abebe,2 Fikru Mekonnen Abebe,3 Molla Mesele Wassie2 1Department of Clinical Nursing, Gambella Teachers Education and Health Science College, Gambella, 2Human Nutrition Department, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, 3Department of Plant Science, College of Agriculture, Wollo University, Dessie, Ethiopia Background: Zinc deficiency is a major public health problem in many developing countries. It has been linked with reduced growth and development in adolescents. The deficiency increases vulnerability to infections, immune dysfunction, hypogonadism, and abnormal neurosensory changes. However, this problem has not received due attention, especially in Ethiopia. Therefore, this study is aimed to assess the prevalence and factors associated with low serum zinc concentration in high
Evidence suggests that New Zealand (NZ) children are mildly zinc deficient and may respond to dietary change. A 20-wk randomized intervention trial was therefore conducted to determine whether an increased intake of red meat or consumption of a fortified manufactured toddler milk drink (FTMD, fortified with zinc and other micronutrients) would increase dietary zinc intakes and improve the biochemical zinc status of 12- to 20-mo-old NZ toddlers. Toddlers were randomized to a red meat intervention (n = 90), FTMD intervention (n = 45), or nonfortified milk placebo (n = 90). Study foods were provided. Adherence was assessed via monthly 7-d meat or milk recording diaries. Hair and serum zinc concentrations, and length and weight were measured at baseline and postintervention. Nutrient intakes were assessed via 3-d weighed food records at baseline, wk 4, and wk 18. At baseline, 38% of participants had low serum zinc concentrations despite seemingly adequate dietary zinc intakes (,4% below the ...
Plasma concentrations of some micronutrients are altered in the setting of acute infectious or inflammatory stress. Previous studies have provided conflicting evidence concerning the extent and direction of changes in plasma zinc concentrations during the acute phase response. We carried out an observational cohort study in 689 children enrolled in a randomized trial of zinc supplementation during acute falciparum malaria in order to evaluate the relation between plasma zinc concentration and the acute phase response. Plasma zinc was measured by atomic absorption spectrophotometry. On admission, 70% of all subjects had low plasma zinc (|9.2 μmol/L). Multivariate analysis of predictors of admission plasma zinc showed that admission C-reactive protein (CRP), parasite density, and study site were the most important predictors. Predictors of changes in plasma zinc from admission to 72 h included baseline CRP, change in CRP, treatment group, study site, and baseline zinc concentration. In children with
Zinc Supplementation to Improve ADHD and Counteract Excess CopperElectromyogram (EMG) tests, which reflect brain activity, have objectively shown that low plasma zinc levels negatively affect information processing. 28 medication-free boys with ADHD, aged 7 to 12, were compared to 24 control children. Event-related potential indices from parietal and frontal brain regions showed that ADHD children had worse working memory (lower amplitudes of P3) and slower information processing (longer latency of P3) compared to control children. Individuals with ADHD and zinc levels ,80 μg/dL showed worse information processing and inhibition (shorter latencies of N2). Plasma zinc levels were significantly lower in ADHD individuals than in controls, but brain waves began to normalize with increasing plasma zinc levels (Yorbik et al., 2008).. Zinc supplements improve symptoms more than placebo and enhance the effectiveness of stimulant medications. When 400 ADHD children aged 6 to 14 were randomized to zinc ...
Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Forty-five rats were divided randomly into three groups: normal zinc diet (30 mg/kg), low zinc diet (10 mg/kg), and pair-fed diet(30 mg/kg). The concentrations of 16 minerals and trace elements in serum, feces, urine, and liver were measured by inductively coupled plasma mass spectrometry. The excretion of 16 elements in urine and feces were calculated and compared. Zinc-deficient rats exhibited significant changes in up to 12 minerals and trace elements. The low zinc diet induced decreased excretion of zinc and concentrations of zinc in serum, feces, urine, and liver. Zinc deficiency increased feces concentrations of Mg, Cu, Se, K, Ag, Fe and Mn; decreased the concentrations of Mg, Cu, Se, K in liver and urine, and a diminished amount of Ag was observed in serum.
The association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studies evaluating the association between serum zinc level and PE were included. The I2 was used to assess heterogeneity and the random effect model (REM) was adopted as the pooling method. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association between serum zinc level and PE. Seventeen observational studies were included. Compared with healthy pregnancy controls, PE patients have lower serum zinc level in 14 studies about total PE (SMD (95% CI): −0.587 (−0.963, −0.212), Z = 3.06, p for Z = 0.002; I2 = 88.4%, p for I2 < 0.0001). In subgroup analysis, a lower serum zinc level in PE patients compared with healthy pregnancy controls was observed in
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and neutrophil function. The study will be conducted on 30 adult patients aged grater than 18 years, of both genders who have undergone surgical resection of colonic neoplastic lesions without metastatic lesion. Patients will be randomized into two groups, with the first (Group QT Zn, n = 15) receive 70 mg/d of zinc for 16 weeks and the second will receive placebo (QT Placebo Group, n = 15). The study will also include 30 healthy volunteers who receive supplementation of 70 mg/d of Zn (C Zn group, n = 15) or placebo (Group C Placebo, n = 15). Zinc supplementation or placebo for all study groups will start two days before the volunteers received the pneumococcal vaccine, polyvalent 23. Fifteen days after vaccination, patients begin chemotherapy as pre-established criteria by the ...
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and neutrophil function. The study will be conducted on 30 adult patients aged grater than 18 years, of both genders who have undergone surgical resection of colonic neoplastic lesions without metastatic lesion. Patients will be randomized into two groups, with the first (Group QT Zn, n = 15) receive 70 mg/d of zinc for 16 weeks and the second will receive placebo (QT Placebo Group, n = 15). The study will also include 30 healthy volunteers who receive supplementation of 70 mg/d of Zn (C Zn group, n = 15) or placebo (Group C Placebo, n = 15). Zinc supplementation or placebo for all study groups will start two days before the volunteers received the pneumococcal vaccine, polyvalent 23. Fifteen days after vaccination, patients begin chemotherapy as pre-established criteria by the ...
One of the major functions of the metal response element-binding transcription factor 1(MTF-1) is to sense and maintain sub-nanomolar to nanomolar zinc levels in response to influxes of labile zinc within the cell. MTF-1 responses to elevated zinc include up regulation of metallothionein (MT-I & II) and efflux transporter (ZnT1) genes. MTF-1 also responds to oxidative stress and heavy metal loads. Due to a lack of liver development, MTF-1 is essential for embryogenesis as determined from knockout mice. The zinc dependence of DNA-binding and interactions with other transcription factors has been identified as major determinants in the homeostatic regulation of labile intracellular zinc by MTF-1. p300 along with its paralog, cyclic-AMP response element binding protein (CBP), have histone acetyltransferase protein scaffold functions and interact with other transcription factors. Previous studies have shown that p300, Sp1 and MTF-1 form a complex. It was also found that a zinc dependent interaction ...
Maternal plasma zinc concentrations and pregnancy outcome.: We conclude that plasma zinc concentrations during the late first trimester to the early third trime
Mechanisms through which gene expression is regulated by zinc are central to cellular zinc homoeostasis. In this context, evidence for the involvement of zinc dyshomoeostasis in the aetiology of diseases, including Type 2 diabetes, Alzheimers disease and cancer, highlights the importance of zinc-regulated gene expression. Mechanisms elucidated in bacteria and yeast provide examples of different possible modes of zinc-sensitive gene regulation, involving the zinc-regulated binding of transcriptional activators and repressors to gene promoter regions. A mammalian transcriptional regulatory mechanism that mediates zinc-induced transcriptional up-regulation, involving the transcription factor MTF1 (metal-response element-binding transcription factor 1), has been studied extensively. Gene responses in the opposite direction (reduced mRNA levels in response to increased zinc availability) have been observed in mammalian cells, but a specific transcriptional regulatory process responsible for such a ...
Among the first-line defense genes, ZRT1, ZRT2, and FET4 are induced by mild zinc deficiency to increase the ability of the cell to accumulate zinc from its environment. ZPS1 is also induced under these mild conditions and we have previously proposed that its product, a secreted protein related to metalloproteases, may also be involved in zinc acquisition by degrading extracellular proteins and releasing any bound metals [3]. Similarly, ZRT3 is up-regulated by mild zinc deficiency and also responds rapidly to zinc withdrawal. Thus, mobilization of zinc stores from the vacuole is also a first-line response. Induction of the YOR387C gene in response to mild zinc deficiency suggests that this gene is also involved in the first-line defense against zinc limitation. The function of this protein is not yet known but its pattern of regulation by zinc suggests that it may play a role in zinc uptake or vacuolar zinc export. TIS11 ( also known as CTH2) is also induced in LZM + 300 μM ZnCl2. Tis11 binds ...
PubMedID: 23039265 | Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes. | Autoimmunity | 2/1/2013
A new review of past studies suggests that taking zinc may cut the time adults have to suffer with a common cold, but the alternative treatment will likely come with unpleasant side effects.
What are zinc supplement health benefits are also such that you can increase it by having dairy products, eating wholegrain foods, lentils, pulses. Also even pumpkin is a very good source of zinc. Also zinc lozenges are easily available in drug stores which are mostly taken if you have cough or cold. What are zinc supplement health benefits is not a question to worry now so let me tell you what is the daily dose recommended for each person to be taken. For adults and teenage males it os preferred to be 9-12mg, pregnant women is to be 15mg, children from 1-10 years 3-9mg, and infants are preferred to take 2-3mg. So What are zinc supplement health benefits is now true. Also while seeing What are zinc supplement health benefits let me tell you that excess of anything is always harmful now this can be just anything. So excess of zinc in our body can prove to be fatal as it is toxic and reduces the function of iron and the iron levels in our body. So relating to What are zinc supplement health ...
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Poudel, an associate professor of community health education at UMass Amhersts School of Public Health and Health Sciences, with his colleagues epidemiologist Elizabeth Bertone-Johnson and Kalpana Poudel-Tandukar of the UMass Amherst College of Nursing, report in the current issue of Biological Trace Element Research that they observed a significant relationship between serum zinc concentration and serum C-reactive protein (CRP) concentration in HIV-positive individuals: higher zinc concentrations were associated with lower CRP levels.. CRP is a biomarker of inflammation that has been associated with several parameters of HIV disease progression and the focus of extensive epidemiologic investigation because it is also an independent survival predictor, Poudel says.. "The fact that several studies have suggested that zinc might be something important for us to be aware of led us to analyze this micronutrient in HIV-positive patients," Poudel says. "We hypothesized that lower concentrations of ...
Evidence supporting the impact of therapeutic zinc supplementation on the duration and severity of diarrhea among children under five is largely derived from studies conducted in South Asia. China experiences a substantial portion of the global burden of diarrhea, but the impact of zinc treatment among children under five has not been well documented by previously published systematic reviews on the topic. We therefore conducted a systematic literature review, which included an exhaustive search of the Chinese literature, in an effort to update previously published estimates of the effect of therapeutic zinc. We conducted systematic literature searches in various databases, including the China National Knowledge Infrastructure (CNKI), and abstracted relevant data from studies meeting our inclusion and exclusion criteria. We used STATA 12.0 to pool select outcomes and to generate estimates of percentage difference and relative risk comparing outcomes between zinc and control groups. We identified 89
1. To investigate the influence of hormonal conditions upon the kinetics of zinc transport, specific radioactivity of 65Zn was determined in certain tissues and fluids from unmated or pregnant rabbits during the first half of gestation. 2. Compartmental analysis was used to find the simplest mathematical model that simulated satisfactorily tracer behaviour. Models were fitted to experimental results by a numerical procedure using a computer. 3. The kinetics of zinc exchange in most tissues investigated could adequately be described by a three-compartment model, in which total tissue zinc content was divided into a rapidly exchanging pool, with a turnover time of about 1h, and a slowly exchanging pool, the turnover time of which was in liver 15h, in peak-stage corpus luteum 8h, and in the other tissues 30-70h. 4. In rabbit endometrium zinc transport varied with hormonal conditions, the turnover rate being higher in non-pregnant than pregnant endometrium. 5. Uptake of 65Zn by uterine fluid was ...
Public Release: 27-Jan-2016 Tufts University, Health Sciences Campus BOSTON (Jan. 27, 2016)--The immune system weakens as the body ages, making older adults more susceptible to infections. Low levels of zinc impair immunity, particularly in older adults. A research team set out to determine if it was feasible to increase serum zinc concentrations in older…
Plasma zinc concentrations during the first 2 years after diagnosis of insulin-dependent diabetes mellitus: a prospective study. ...
Zinc, like other neurotransmitters, has been shown to act as a transmembrane signal in neurons. Synaptically released zinc from presynaptic neurons enters the adjacent postsynaptic neurons and glial cells through voltage-gated zinc or calcium channels and functions as a cell-to-cell signaling modulator (Pan et al., 2011). Zinc has also been shown to be a novel second messenger for signal transduction (Yamasaki et al., 2007). To explore the mechanism by which zinc induces sperm activation, we compared the intracellular zinc distribution pattern before and after sperm activation using a membrane-permeable fluorescent probe of zinc, zinpyr-1 (Kd=0.7±0.1 nM). Surprisingly, we found that in non-activated spermatids zinc ions were highly enriched in vesicular structures even in the absence of the exogenous zinc (Fig. 2A). Labile zinc was also observed in the mitochondria in spermatids as indicated by the colocalization of zinpyr-1 and MitoTracker (Fig. 2A). Treatment with the zinc-specific chelator ...
Abstract. Approximately 10% of the U.S. population ingests ,50% of the current recommended daily allowance for zinc. We investigate the effect of zinc deficiency on DNA damage, expression of DNA-repair enzymes, and downstream signaling events in a cell-culture model. Low zinc inhibited cell growth of rat glioma C6 cells and increased oxidative stress. Low intracellular zinc increased DNA single-strand breaks (comet assay). Zinc-deficient C6 cells also exhibited an increase in the expression of the zinc-containing DNA-repair proteins p53 and apurinic endonuclease (APE). Repletion with zinc restored cell growth and reversed DNA damage. APE is a multifunctional protein that not only repairs DNA but also controls DNA-binding activity of many transcription factors that may be involved in cancer progression. The ability of the transcription factors p53, nuclear factor κB, and activator protein 1 (AP1) to bind to consensus DNA sequences was decreased markedly with zinc deficiency, as assayed by ...
Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters and diet. A case-control study was performed in a group of adolescents with Down syndrome (n = 30) and a control group (n = 32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition. The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes, and 24-h urinary zinc excretion, by using the method of atomic absorption spectroscopy. The diet of both groups presented adequate concentrations of lipids, proteins, ...
Last update on 2020-03-30 / Links & Images from Amazon Product Advertising API. Zinc is an essential trace element and it doesnt take a lot to help maintain optimal health. In fact, the National Institutes of Health recommends only 11 mg and 8 mg of Zinc respectively for males and females. Moreover, its also rare to experience severe Zinc deficiency as most diets already have more than enough Zinc.. On the other hand, mild Zinc deficiency is quite common for the general population and interestingly, it happens mostly because of inadequate Zinc intake. As one study suggests, "25% of the worlds population is at risk of zinc deficiency" - and thats a conservative estimate. That being said, Zinc is notably good for the immune system and lack of Zinc typically results in immune related symptoms.. However, since Zinc is "a component of more than 300 enzymes and an even greater number of other proteins" (as per a 2010 study), lack of this mineral also inevitably causes emasculating side effects ...
Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model (FIAM) is well-established in the literature, and shows that just micromolar amounts of the free ion kills some organisms. A recent example showed 6 micromolar killing 93% of all daphnia in water.[4] Swallowing a post 1982 American one cent piece (97.5% zinc) can also cause damage to the stomach lining due to the high solubility of the zinc ion in the acidic stomach.[5] Zinc toxicity, mostly in the form of the ingestion of US pennies minted after 1982, is commonly fatal in dogs where it causes a severe hemolytic anemia.[6] In pet parrots zinc is highly toxic and poisoning can often be fatal[7]. There is evidence of induced copper deficiency at low intakes of 100-300 mg Zn/d. The USDA RDA is 15 mg Zn/d. ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
In order for your immune system to function properly, you need to support it with proper nutrition, nutritional supplements and herbs. It is important that you eat more fresh fruit and vegetables (preferably organic) that are rich in vitamins, esp. vitamin C, and minerals, esp. zinc. Zinc may be the most important micro nutrient for your immune system. It is needed for the stimulation of the white blood cells that are important elements of your defense system. People who are deficient in zinc are more susceptible to infections. Zinc works in synergy with vitamin C and in order to be effective in your body it must be taken with its co-factor amino acid Histidine. Taken alone, zinc may be ineffective as the foods you eat interfere with its absorption, especially when you are a vegetarian. The recommended dose is 15 mg per day with up to 1000 mg vitamin C and 100-500 mg Histidine. The other important vitamin for the immune system is the vitamin D3 which works in the body as a potent antibiotic. ...
Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a decrease in the serum concentration is only detectable after long-term or severe depletion, serum zinc is not a reliable biomarker for zinc status. Common symptoms include increased rates of diarrhea, pneumonia, and malaria.[citation needed] Zinc deficiency affects the skin and gastrointestinal tract; and the central nervous, immune, skeletal, and reproductive systems. Zinc deficiency in humans is caused by reduced dietary intake, inadequate absorption, increased loss, or increased body system utilization. The most common cause is reduced dietary intake. In the U.S., the Recommended Dietary Allowance (RDA) is 8 mg/day for women and 11 mg/day for men. Zinc plays an essential role in numerous biochemical pathways. The highest concentration of dietary zinc is found in oysters, meat, beans, and nuts. Increasing the amount of zinc in the soil and thus ...
According to the reference(1), concentration of total Zn in root of wheat seedlings cytoplasm can be 0.4mM (i.e. about 25mg/L). However, based on a widely used recipe of plant growing medium -- Murashige and Skoog salt(2), Zn concentration at 0.03 mM (1.95mg/L of Zn2+) will be enough for many kinds of plants. I am not sure what plant your are testing and what the environment you are applying on the plant, both would influence your experimental result. But generally speaking, plant in 0.1mg/l solution would probably show one or several Zn deficiency symptoms, like: young leaves growth reduction; leaf margin distorted or puckered; light sensitive and interveinel choloroses in leaves; retardation of stem growth(3). However I did not find reference about the effects of excessive Zn for plant, probably because in nature, the problem for plants is deficiency of Zn rather than excess of it. I would like to know your experimental results, especially the one about 100mg/L Zn. About the function of Zn, ...
...BOSTON When elderly nursing home residents contract pneumonia it is...Based on our data it appears that daily zinc intake can help nursing ...Meydani and colleagues analyzed blood samples from a previous study th...In the present study published in the October issue of the American J...,Zinc,may,reduce,pneumonia,risk,in,nursing,home,elderly,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Acta Neurobiol Exp (Wars) 2013; 73 (2): 225-236 ABSTRACT. Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency. MTs are proteins with important functions in metal metabolism and protection. Zinc and Cu bind to and participate in the control of the synthesis of MT proteins. Studies indicate that the GABAergic system may be involved in ASDs, and that Zn and Cu may play a role in this system.. ...
Introduction Type 2 diabetes mellitus (T2DM) is a group of pandemic debilitating metabolic diseases featuring chronic hyperglycemia that results from defective insulin secretion and/or insulin actions. Dame and Sutor reported that diabetic patients are prone to thrombocytosis through a complex interplay of mechanisms. Therefore, the aim of our work is to evaluate serum sclerostin levels in patients with T2DM and to analyze the relationships among sclerostin, bone mineral density (BMD), bone metabolism, and thrombocytosis. Objective This study aimed to evaluate serum sclerostin in T2DM and its correlations with bone metabolism and thrombocytosis. Patients and methods Fifty male T2DM patients were enrolled; they were divided into two groups according to existing thrombocytosis. Forty age-matched men were included as controls. Clinical tests of physical mobility, fasting blood glucose, glycated hemoglobin, calcium, creatinine, parathormone (PTH), 25-hydroxyvitamin D, bone-specific alkaline ...
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Adults who take zinc supplements at the first sign of a cold may shave almost two days off of their sniffling, sneezing, and coughing, a new review study suggests.
e evaluated the effect of one year of supplementation with iron plus zinc (12 mg/d Fe+++ and 12.5 Zinc++), zinc alone (12.5 mg/day of Zn++) and placebo on the iron, copper and selenium tissue contents in 30 well-selected children of short stature (16 M and 14 F; 4-11 years old). Before and after supplementation, we measured the concentrations of iron, transferring, ferritin, zinc and copper in serum of erythrocytes and leukocytes, and of zinc, copper and selenium in hair, as well as glutathion peroxidase activity in erythrocytes. Before supplementation, ferritin and erythrocyte and hair zinc contents were significantly lower than in age-matched control, while the other measured indices were in the normal range. Iron plus zinc supplementation caused an improvement in growth rate in all subjects, i.e. the medium Zscore increased from -2.22 +/- 0.45 t0 -0.65 +/-0.55 (p,0.01) In the zinc-supplemented group, only subjects whose ferritin levels were higher than 20 ng/L before supplementation showed ...
Diarrhoea remains a leading cause of death globally among children under five years of age. Diarrhoea contributes to nutritional deficiencies, reduced resistance to infections and impaired growth and development. Severe diarrhoea leads to fluid loss, and may be life-threatening, particularly in young children and people who are already malnourished or have impaired immunity.. Zinc is important for cellular growth, cellular differentiation and metabolism and deficiency limits childhood growth and decreases resistance to infections. Although severe zinc deficiency is rare in humans, mild to moderate deficiency may be common worldwide.. Zinc supplementation has been shown to reduce the duration and severity of diarrhoea, and to prevent subsequent episodes, although the mechanisms by which zinc exerts its anti-diarrhoeal effect are not fully understood. ...
Time: Tuesday 17 June, 2014 at 9-13. Place: University of Eastern Finland (UEF), Kuopio Campus, Snellmania Building, seminar room S21 (NOTE: ROOM CHANGED), address: Yliopistoranta 1 E, Kuopio. 9.00 Coffee and Welcome, Prof. Sirpa Kärenlampi, UEF, Department of Biology. 9.15 Identification and differential expression of miRNAs in animal model. Xiaoju Hu, Institute of Zoology, Chinese Academy of Sciences, P.R. China Histidine mediates the xylem loading of Zn and Ni, but not Cd, in Noccaea caerulescens. Dr. Henk Schat, Vrije Universiteit Amsterdam, Department of Genetics, the Netherlands Gene structure annotation of Noccaea caerulescens. Daniel Blande, UEF, Department of Biology.. ~11.00 Lunch break. 11.45 Natural variation for the response to Zn deficiency in Arabidopsis thaliana. Dr. Mark Aarts, Wageningen University, Laboratory of Genetics, the Netherlands Differential response of two Noccaea caerulescens accessions to cadmium. Pauliina Halimaa, UEF, Department of Biology. 12.45 Closing ...
Isolation of cells differentially expressing lacZ activity: After development of the X-gal color for 2 wk, the membranes were photographed using Ektapan (Kodak, 4162) film and the resulting pairs of negatives were superimposed with a slight offset and examined by eye against a clear incandescent lightbulb. By applying strips of removable tape, the negatives were readily scanned for colonies putatively exhibiting differential lacZ expression. Colonies on the master plate were located by comparison with prints from the negatives. To purify the clones and document zinc-regulated lacZ expression, clones of interest were dispersed into 1 ml of low-zinc, Leuselective medium and 1 μl of this suspension spread as sectors on another low-zinc, Leu-selective plate. After colonies reached full size, the replica-plating procedure was repeated. About 70% of the clones exhibited perceptible differences in X-gal color in the two growth conditions and were kept for further study.. Identification of sequences ...
Zinc has been shown to be a likely tumor suppressor in the commonest form of pancreatic cancer by scientists from University of Maryland.
The present study was conducted to test the hypothesis that low concentrations of coated ZnO, as a substitute for a high concentration of ZnO (2250 mg Zn/kg), could improve intestinal immunity function and regulate microbiota composition, thus alleviating the incidence of diarrhoea in weaned piglets. A total of eighty-four cross-bred piglets, weaned at an age of 28 (sem 1) d, were allocated randomly, on the basis of average initial body weight (7·72 (sem 0·65) kg), to seven treatment groups as follows: a 250 mg Zn (ZnO)/kg group (low Zn; LZ) and a 2250 mg Zn (ZnO)/kg group (high Zn; HZ) that were offered diets containing ZnO at 250 and 2250 mg Zn/kg, respectively; and five experimental groups in which coated ZnO was added at 250, 380, 570, 760 and 1140 mg Zn/kg basal diet, respectively. The trial lasted 2 weeks. The results indicated that, compared with LZ treatment, supplementation with coated ZnO at 380 or 570 mg Zn/kg reduced (P, 0·05) diarrhoea index, increased (P, 0·05) duodenal villus ...
Groups of 50 male and 50 female rats were fed diets containing varying levels of dietary zinc [3.5, 7, 38 (control), 250, or 500 ppm] for 104 to 106 weeks. The 3.5 and 7 ppm diets were considered to be zinc deficient, the control diet of 38 ppm was considered to be zinc sufficient, and the 250 and 500 ppm dietary zinc concentrations represented diets with excess zinc. Dietary concentrations of 3.5, 7, 38, 250, and 500 ppm resulted in average daily intakes of 0.1, 0.3, 1.4, 8.7, and 17.6 mg dietary zinc/kg body weight to males and 0.1, 0.3, 1.5, 9.9, and 19.9 mg/kg to females. Ten male and 10 female additional special study rats were exposed to the same concentrations for 53 weeks and used for micronuclei evaluations, comet assays, hematology, and trace metal concentration determinations.. There were no chemical-related effects on survival. However, male rats maintained on the 3.5 ppm zinc-deficient diet had an increased survival rate compared to the controls that was likely due to low survival ...
In this randomized controlled trial, we did not find any significant difference in the need for antibiotics, intravenous antibiotics, hospitalization or colonization with Pseudomonas among children with cystic fibrosis receiving zinc supplementation of 30 mg daily as compared with those receiving placebo.. There is a paucity of data on the role of zinc in cystic fibrosis. It is thought that steatorrhea causes loss of zinc in the stool and should lead to low zinc levels among children with cystic fibrosis. However, no such relation was found in the study on 36 children with cystic fibrosis by Van Biervliet et al.14 Another study reported that serum zinc levels in children with cystic fibrosis were similar to those of normal controls but that children with lower serum zinc levels had significantly worse results on the pulmonary function tests.15 An increase has been observed in the sputum zinc levels in pulmonary exacerbations, and a decrease has been observed in the levels after treatment in ...
Zinc is a vital micronutrient essential for protein synthesis, cell growth and differentiation, immune function, and intestinal transport of water and electrolytes.1 Zinc is also important for normal growth and development of children both with and without diarrhoea.2 Zinc deficiency is associated with an increased risk of gastrointestinal infections, altered structure and function of the gastrointestinal tract and impaired immune function.3-5 Dietary deficiency of zinc is especially common in low-income countries because of a low dietary intake of zinc-rich foods (including foods of animal origin) or low bioavailability due to the presence of phytates often found in cereal-based diets.1. The benefits of zinc supplementation in the management of diarrhoea have been observed in several studies. Patel et al6 noted in a systematic review and meta-analysis an approximate 20% reduction in the mean duration of acute diarrhoea with zinc supplementation. Lazzerini and Wanzira,7 summarising data from ...
Severe, or even marginal, deficiencies of zinc lead to reversible dysfunctions of human T lymphocytes.. Zinc deficiency is easily produced in laboratory animals, with a prompt development of numerous abnormalities in immune functions. Zinc deficiency consistently leads to atrophy of the thymus and other lymphoid organs, to reduced lymphocyte numbers in tissues (especially in the T cell areas) and to lymphopenia. Zinc deficiency is accompanied by anergy, manifested predominantly by dysfunctions of cellmediated immunity, along with some depression in the production of T cell-dependent antibodies and splenic plaque-forming cells.. Zinc deficiency initiates a selective decrease in CD4f helper cell numbers. In vitro testing reveals a markedly reduced proliferative response by these cells to phytohemagglutinin and other mitogens. Natural killer cells also show decreased activity and T cell-mediated cytotoxicity is reduced. In zinc-deficiency, lymphocytes have a reduced ability to produce interleukin 2 ...
Decades after the discovery that ionic zinc is present at high levels in glutamatergic synaptic vesicles, where, when, and how much zinc is released during synaptic activity remains highly controversial. Here we provide a quantitative assessment of zinc dynamics in the synaptic cleft and clarify its role in the regulation of excitatory neurotransmission by combining synaptic recordings from mice deficient for zinc signaling with Monte Carlo simulations. Ambient extracellular zinc levels are too low for tonic occupation of the GluN2A-specific nanomolar zinc sites on NMDA receptors (NMDARs). However, following short trains of physiologically relevant synaptic stimuli, zinc transiently rises in the cleft and selectively inhibits postsynaptic GluN2A-NMDARs, causing changes in synaptic integration and plasticity. Our work establishes the rules of zinc action and reveals that zinc modulation extends beyond hippocampal mossy fibers to excitatory SC-CA1 synapses. By specifically moderating GluN2A-NMDAR ...
Zinc is one of the essential micronutrients, and plays an important role in human nutrition and health. In 1961, Prasad first recognized zinc deficiency as the cause of dwarfism and hypogonadism among iron-deficient adolescent Iranian village boys.1,2. Zinc deficiency occurs in individuals and populations with diets low in sources of readily bioavailable zinc, such as red meat, and high in unrefined cereals that are rich in phytate. The elderly population is potentially vulnerable to zinc deficiency because of decreased intake of food energy, protein, vitamins and minerals, and increased intake of carbohydrates.3,4 In this review, we discuss the importance of zinc to humans, as well as the causes, clinical features and management of zinc deficiency in the elderly population.. Importance of ...
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