Anyone know of a RAT Y CHROMOSOME specific probe? Thanks in advance Abizar www.innogenex.com , -----Original Message----- , From: Angeline Martin-Studdard [mailto:[email protected]] , Sent: Monday, January 22, 2001 4:57 AM , To: [email protected] , Subject: mouse Y chromosome probe , , , Hi Dina, , , Ive been utilizing a mouse Y chromosome paint probe from Applied , Genetics (#BMPOY). I tested it on cell drop slides initially and , currently use it on paraffin embedded mouse brain tissue. Ive , only tested a few different fixation methods so far but hope to , make more progress with that in the near future. It works well , and Ive found I can get away with quite a bit less probe than , recommended. , , Let me know if you would like any more information. , Angeline , , Medical College of Georgia , Neurology , 1459 Laney-Walker Blvd , Augusta, GA 30912 , [email protected] , , , ,Date: 19 Jan 2001 15:21:31 -0600 , ,From: [email protected] , ,Subject: mouse Y chromosome ...
Radiolabeled reiterated DNA specific for the human Y chromosome has been obtained by extensive reassociations between [3H]DNA prepared from men and excess DNA from women. These highly purifed labeled sequences reassociate only with DNA from individuals with a Y chromosome. The percentage of Y-chromosome-specific DNA isolated from individuals with differing numbers of Y chromosomes is a function of the number of chromosomes present. The purifed Y-chromosome-specific sequences may represent between 7 and 11 percent of the human Y chromosome. ...
Silene latifolia has heteromorphic sex chromosomes, the X and Y chromosomes. The Y chromosome, which is thought to carry the male determining gene, was isolated by UV laser microdissection and amplified by degenerate oligonucleotide-primed PCR. In situ chromosome suppression of the amplified Y chromosome DNA in the presence of female genomic DNA as a competitor showed that the microdissected Y chromosome DNA did not specifically hybridize to the Y chromosome, but hybridized to all chromosomes. This result suggests that the Y chromosome does not contain Y chromosome-enriched repetitive sequences. A repetitive sequence in the microdissected Y chromosome, RMY1, was isolated while screening repetitive sequences in the amplified Y chromosome. Part of the nucleotide sequence shared a similarity to that of X-43.1, which was isolated from microdissected X chromosomes. Since fluorescence in situ hybridization analysis with RMY1 demonstrated that RMY1 was localized at the ends of the chromosome, RMY1 may ...
Chimp and Human Y Chromosomes Evolving Faster Than Expected Wednesday, 13 January 2010 Contrary to a widely held scientific theory that the mammalian Y chromosome is slowly decaying or stagnating, new evidence suggests that in fact the Y is actually evolving quite rapidly through continuous, wholesale renovation. By conducting the first comprehensive interspecies comparison of Y chromosomes, Whitehead Institute researchers have found considerable differences in the genetic sequences of the human and chimpanzee Ys - an indication that these chromosomes have evolved more quickly than the rest of their respective genomes over the 6 million years since they emerged from a common ancestor. The findings are published online this week in the journal Nature. "The region of the Y that is evolving the fastest is the part that plays a role in sperm production," say Jennifer Hughes, first author on the Nature paper and a postdoctoral researcher in Whitehead Institute Director David Pages lab. "The rest of ...
Compared with the X chromosome, the mammalian Y chromosome is considerably diminished in size and has lost most of its ancestral genes during evolution. Interestingly, for the X-degenerate region on...
By one estimate, the human Y chromosome has lost 1,393 of its 1,438 original genes over the course of its existence, and linear extrapolation of this 1,393-gene loss over 300 million years gives a rate of genetic loss of 4.6 genes per million years.[21] Continued loss of genes at the rate of 4.6 genes per million years would result in a Y chromosome with no functional genes - that is the Y chromosome would lose complete function - within the next 10 million years, or half that time with the current age estimate of 160 million years.[16][22] Comparative genomic analysis reveals that many mammalian species are experiencing a similar loss of function in their heterozygous sex chromosome. Degeneration may simply be the fate of all non-recombining sex chromosomes, due to three common evolutionary forces: high mutation rate, inefficient selection, and genetic drift.[16] However, comparisons of the human and chimpanzee Y chromosomes (first published in 2005) show that the human Y chromosome has not ...
PLENARY PRESENTATION TUESDAY OCTOBER 19 2.00pm - 2.30pm SEQUENCE OF THE MOUSE Y CHROMOSOME Alfoldi JE1, Skaletsky H1, Graves T2, Minx P2, Wilson RK2, Rozen S1, Page DC1 1 Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, United States, 2 Genome Sequencing Center, Washington University School of Medicine, St. Louis, United States Y chromosomes have no partner with which to cross-over during meiosis, and so were once thought to be doomed to degeneration and gene loss. However, the recent discovery of palindromes on the human Y chromosome has given us hope of the continued survival of Y genes, since palindromes could be protecting their genes by gene conversion. The sequencing of the mouse Y chromosome was begun with the hope that it too has palindromes, and that these palindromes could be studied more easily in a more tractable organism. Now that some mouse Y sequence has been produced, we can see that this chromosome ...
Researcher(s): William J. Murphy, PhD Breed(s): All (non-specified). Abstract:. Studies of the human and mouse Y chromosomes have shown that they contain many testis specific genes that, when defective, cause infertility and spermatogenesis defects. The causes of male infertility in dogs are not well known. Though much is now known about genes on the dog autosomes and X chromosome, owing to the canine genome sequence, virtually nothing is known about the canine Y chromosome and the genes it harbors. This study will exhaustively characterize the gene content of the dog Y chromosome by sequencing from a cDNA selection library that is enriched for Y chromosome gene transcripts. This procedure will isolate the majority of canine Y chromosome genes and the DNA fragments they reside on, which will be mapped in the dog genome. The copy number and expression profile of these genes will be determined in a broad range of tissues to discern which genes have testis-specific expression patterns, and may ...
Among the many chromosomes in a mans body, the smallest one with the largest personality has to be the Y chromosome. With it, you are a male; without it, you are a female, with few exceptions. More than any other chromosome, it really defines who you are.. The Y chromosome controls other traits as well: hairy ears, tooth enamel, and stature to name a few. But for the longest time, the Y chromosome was also considered home to a lot of "junk DNA" that we thought had no purpose. We now know that much of this DNA has a purpose and that the Y is the home of many important male fertility genes.. Before its association with male fertility, the Y chromosome was widely considered a genetic black hole, a chromosome that evolved as a broken remnant of the X chromosome. We knew that the "maleness" gene was on the Y and a few other genes. However, since the Y chromosome has been fully undressed as a result of the human genome project, we now know that it is very unique, even special, and that it evolves in ...
Definition of Y chromosome in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Y chromosome? Meaning of Y chromosome as a finance term. What does Y chromosome mean in finance?
Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y biology across the tree of life. Here, we leverage long single-molecule sequencing to determine the content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, Anopheles gambiae We find that the An. gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of which can recombine with similar repeats on the X chromosome. Sex-specific genome resequencing in a recent species radiation, the An. gambiae complex, revealed rapid sequence turnover within An. gambiae and among species. Exploiting 52 sex-specific An. gambiae RNA-Seq datasets representing all developmental stages, we identified a small repertoire of Y-linked genes that lack X ...
The chromosome Y sequence has the pseudoautosomal regions (PAR) hard masked. This practice is consistent with the 1000 Genome Consortiums decision to hard mask these regions in chromosome Y in order to prevent mis-mapping of reads and issues in variant calling on the gender chromosomes.. The masked Y pseudoautosomal regions are chrY:10001-2649520 and chrY:59034050-59363566. (A related file can be downloaded from ftp://ftp.ensembl.org/pub/release-56/fasta/homo_sapiens/dna/Homo_sapiens.GRCh37.56.dna.chromosome.Y.fa.gz.). The following background information is from the UCSC site http://genome.ucsc.edu/cgi-bin/hgGateway?org=human&db=hg19 The Y chromosome in this assembly contains two pseudoautosomal regions (PARs) that were taken from the corresponding regions in the X chromosome and are exact duplicates:. chrY:10001-2649520 and chrY:59034050-59363566? chrX:60001-2699520 and chrX:154931044-155260560. ...
History and description of Haplogroup T (Y-chromosomal DNA) and its subclades. Haplogroup T is an old Middle Eastern and East African lineage. It was found among ancient Babylonians, Phoenicians, Greeks and Romans.
An analysis of the genealogical and medical records of males in Utahs multi-generational families strongly supports the case that inherited variations in the Y chromosome, the male sex chromosome, play a role in the development of prostate cancer, according to a study presented on Friday, October 25, at the American Society of Human Genetics (ASHG) 2013 meeting in Boston. The study identified multiple, distinct Y chromosomes associated with a significant excess risk of prostate cancer, said Lisa Cannon-Albright, Ph.D., Professor and Chief of the Division of Genetic Epidemiology at the University of Utah School of Medicine. Dr. Cannon-Albright, who headed the study and presented the results, said that her lab plans to search these Y chromosomes for the genetic mutations that can predispose a man to develop prostate cancer, the second most frequently diagnosed cancer in the U.S. Because most of the Y chromosome does not recombine during cell division, it is passed virtually unchanged from father ...
In order to understand the intricacies of X and Y chromosome evolution, we investigate Y chromosome gene content and structure in our model marsupial, the tammar wallaby (Macropus eugenii ). Using gene-specific and whole Y chromosome probes to screen BAC libraries, we have identified novel genes on the wallaby Y.. Many of these genes are also conserved on the Y in other Australian (Tasmanian devil) and American (opossum) marsupials, but lost from the Y in placental mammals.. This project will focus on characterising genes on the Tasmanian Devil Y chromosome, not only helping to understand mammal Y chromosomes, but also the X.. ...
Despite this, recent research has shown that the Y chromosome has developed some pretty convincing mechanisms to "put the brakes on", slowing the rate of gene loss to a possible standstill.. For example, a recent Danish study, published in PLoS Genetics, sequenced portions of the Y chromosome from 62 different men and found that it is prone to large scale structural rearrangements allowing "gene amplification" - the acquisition of multiple copies of genes that promote healthy sperm function and mitigate gene loss.. The study also showed that the Y chromosome has developed unusual structures called "palindromes" (DNA sequences that read the same forwards as backwards - like the word "kayak"), which protect it from further degradation. They recorded a high rate of "gene conversion events" within the palindromic sequences on the Y chromosome - this is basically a "copy and paste" process that allows damaged genes to be repaired using an undamaged back-up copy as a template.. Looking to other ...
The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over with the X chromosome1, 2. Little is known about the recent evolution of the Y chromosome because only the human Y chromosome has been fully sequenced. Prevailing theories hold that Y chromosomes evolve by gene loss, the pace of which slows over time, eventually leading to a paucity of genes, and stasis3, 4. These theories have been buttressed by partial sequence data from newly emergent plant and animal Y chromosomes5, 6, 7, 8, but they have not been tested in older, highly evolved Y chromosomes such as that of humans. Here we finished sequencing of the male-specific region of the Y chromosome (MSY) in our closest living relative, the chimpanzee, chieving levels of accuracy and completion previously reached for the human MSY. By comparing the MSYs of the two species we show that they differ radically ...
We rarely use Wikipedia as a resource, but this overview on bone density is quite well done. As with any medical issue or question, please consult your physician. The Wikipedia entry is a general discussion of the topic. It is not specifically related to X and Y Chromosome Variations. For individuals who are 47,XXY, untreated hypogonadism can lead to osteoporosis and osteopenia. Most benefit from testosterone replacement therapy (TRT). Those who identify as intersex or choose not to use TRT should seek competent medical help for alternative methods to preserve bone density.. Read more ...
Genetic conflicts between sexes and generations provide a foundation for understanding the functional evolution of sex chromosomes and sexually dimorphic phenotypes. Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding genes that are monomorphic within species. Nevertheless, polymorphic variation in heterochromatic Y chromosomes of Drosophila result in genome-wide gene expression variation. Here we show that such naturally occurring Y-linked regulatory variation (YRV) can be detected in somatic tissues and contributes to the epigenetic balance of heterochromatin/euchromatin at three distinct loci showing position-effect variegation (PEV). Moreover, polymorphic Y chromosomes differentially affect the expression of thousands of genes in XXY female genotypes in which Y-linked protein-coding genes are not transcribed. The data show a disproportionate influence of YRV on the variable expression of genes whose protein products localize ...
Scientists in the US have published the results of their detailed scrutiny of the genetic sequence of the human Y chromosome. This DNA bundle - one of 24 distinct chromosomes found in human cells - holds the crucial information to make the male of our species. The work is part of the enormous job of following up the data that came out of the international Human Genome Project (HGP)…declared complete in April. Any attempt to make sense of the data inevitably involves large-scale computing effort, but, by any standards, annotating the Y chromosome was a huge task. Its one thing to generate the sequence and its another to go on to discover which bits are functional and what they can tell us about disease and evolution, explained Mark Ross, head of the Wellcome Trust Sanger Institutes project to analyse the X chromosome near Cambridge, UK. The Y chromosome contains a great many repeated sections of DNA and far fewer genes, letter for letter, than other chromosomes. Francis Collins, director of ...
Health,...Countering common belief study shows rapid genetic change in both hum...WEDNESDAY Jan. 13 (HealthDay News) -- The Y chromosome found only in...The new study challenges the widely held belief that the mammalian Y c...The Y chromosome is present in males (who have one Y and one X chromos...,Males,Y,Chromosome,Not,in,Decline,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Basically, a fertilized egg can contain a modified Y chromosome that is itself a palindrome," Page said. "That modified or isodicentric Y chromosome is so unpredictably stable or unstable that individuals who develop from such a fertilized egg range from a man with no sperm who is otherwise healthy to someone raised as a boy who is later found to have an ovary on one side to a girl or woman with Turner syndrome. These wildly different outcomes result from the very same starting point.". The key to an isodicentric Y chromosomes instability is its two centromeres, Page explained. Centromeres are critical for the proper segregation of chromosomes into two daughter cells at each cell division. "If there are two centromeres, the apparatus for partitioning chromosomes becomes very confused," he said. "A chromosome can get tugged in two directions at once." As a result, the chromosome has a tendency to get broken or lost each time cells divide. During the development of an embryo, cells divide ...
A toothpick and a bit of chance shaped David Page’s career, which he has dedicated to understanding the mammalian Y chromosome and fetal germ cell development.
A toothpick and a bit of chance shaped David Pages career, which he has dedicated to understanding the mammalian Y chromosome and fetal germ cell development.. 0 Comments. ...
In this study we have established a simple, accurate and widely applicable method for determining the sex of primate DNA samples by using triple primer PCR of a small region of the UTX/UTY gene. The ubiquitously transcribed tetratricopeptide repeat protein gene (UTX/UTY) is located on the X and Y chromosomes and our analysis identified a region in the human UTY having the highest identity to the mouse Y chromosome. Due to the high conservation of this region the triple primer PCR setup works in all primate species tested. Furthermore, the method contains an internal positive control (the shared primer), but should always be tested in samples of known sex before actual analysis is carried out. Also, it may be necessary to perform species specific optimization of annealing temperature and/or primer concentrations prior to analysis. Since the nature of the Y chromosome allows deletion of many regions, it can be expected that with an increased number of individuals tested deletion of UTY might be ...
Inferring chimpanzee Y chromosome history and amplicon diversity from whole genome sequencing Matthew Oetjens, Feichen Shen, Zhengting Zou, Jeffrey Kidd bioRxiv doi: http://dx.doi.org/10.1101/029702 Due to the lack of recombination, the male-specific region of the Y chromosome (MSY) is a unique resource for tracking the genetic history of populations. The MSY is also enriched for large,…
A few dozen genes are known on the human Y chromosome. The completion of the human genome sequence will allow identification of the remaining loci, which should shed further light on the function and evolution of this peculiar chromosome.
(Phys.org) -University of Arizona geneticists have discovered the oldest known genetic branch of the human Y chromosome - the hereditary factor determining male sex.
The Y chromosome is ane o twa sex chromosomes (allosomes) in mammals, includin humans, an mony ither ainimals. The ither is the X chromosome. Y is the sex-determinin chromosome in mony species, syne it is the presence or absence o Y that determines the male or female sex o offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which causes testis development. ...
This idea is based on evaluations of modern X and Y sex chromosomes that evolutionists think resulted from an original common ancestral pair of identical chromosomes. They speculate that over long ages "genes have been lost from the Y chromosome in humans and other mammals….[but] essential Y genes are rescued by relocating to other chromosomes."3 This conclusion was largely based on a study by Jennifer Hughes and her team.The study used the assumption that "the mammalian X and Y chromosomes evolved from a single pair of autosomes [non-sex chromosomes]."4. A problem is, even assuming evolution occurred, we have no knowledge of the common ancestor of mammals, although several candidates have been proposed. One of the more recent is a "tiny, furry-tailed creature that evolved shortly after the dinosaurs disappeared."5 This 2013 conclusion was considered so radical that some mammalian experts called "for a reevaluation of the evolutionary story of placental mammals."5 If we cannot decide which ...
... : Genes, Leukemias, Solid Tumors, and Cancer-Prone Diseases located on Chromosome Y reviewed and published in the Atlas of Genetics and Cytogenetics in Oncology and Haematology
The most prominent clade in Taiwan, O-M175 as a whole, represents almost 90% of Y chromosomes among the TwHan, about 95% among the TwPlt and more than 99% among the TwMtA (Additional file 1: Figures S1 and S2). Only one representative of the basal O*/O1*-M175 (xM119, P31, M122) was seen in each of the Luzon (Philippines), Fujian and TwPlt samples (Figure 2 and Additional file 1: Table S2). All other haplogroups of the O clade were observed at the derived state for the M119, P31 and M122 markers (Figure 2, Additional file 1: Table S2, and Additional file 1: Figures S1 and S2).. Haplogroup O1a*-M119 (Figure 2 and Additional file 1: Table S2) is seen throughout Batan (42%), the Philippines (4% to 33%) and Indonesia (4% to 18%). It has a patchy distribution among TwMtA (3-33%) and only some southern TwMtA show frequencies greater than 10% (i.e. Puyuma, Paiwan and Yami). O1a*-M119 was not observed in our Amis sample, neither in the Bunun, Saisiyat and Thao and has a low frequency among TwHan (1.4% to ...
What is the difference between X and Y Chromosome? X chromosomes contain genes for female sex determination, but Y chromosome contain genes for male sex ..
This table shows all stocks in the Bloomington collection with a Y chromosome carrying a P{hs-hid} insertion.. Flies carrying this chromosome can be killed during development by high temperatures to produce female-only cultures. See Heat treatment method for P{hs-hid} stocks. See Dominant temperature-sensitive lethal stocks for P{hs-hid} insertions on other chromosomes.. Go back to the main special-purpose Y chromosome page ...
1. KoopmanPGubbayJVivianNGoodfellowPLovell-BadgeR 1991 Male development of chromosomally female mice transgenic for Sry. Nature 351 117 121. 2. GubbayJCollignonJKoopmanPCapelBEconomouA 1990 A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346 245 250. 3. KarlJCapelB 1998 Sertoli cells of the mouse testis originate from the coelomic epithelium. Dev Biol 203 323 333. 4. WylieC 1999 Germ cells. Cell 96 165 174. 5. CoveneyDCoolJOliverTCapelB 2008 Four-dimensional analysis of vascularization during primary development of an organ, the gonad. Proc Natl Acad Sci U S A 105 7212 7217. 6. MartineauJNordqvistKTilmannCLovell-BadgeRCapelB 1997 Male-specific cell migration into the developing gonad. Curr Biol 7 958 968. 7. AlbrechtKHEicherEM 2001 Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor. Dev Biol 240 92 107. 8. AdamsIRMcLarenA 2002 Sexually dimorphic ...
Because selective pressure to pass on advantageous sperm production genes is so high, those genes may also drag along detrimental genetic traits to the next generation. Such transmission is allowed to occur because, unlike other chromosomes, the Y has no partner with which to swap genes during cell division. Swapping genes between chromosomal partners can eventually associate positive gene versions with each other and eliminate detrimental gene versions. Without this ability, the Y chromosome is treated by evolution as one large entity. Either the entire chromosome is advantageous, or it is not ...
MSY1 is the only hypervariable minisatellite on the human Y chromosome. Arrays contain 22-114 AT-rich repeat units of 25bp in length, of which eighteen different sequence-variant types have been identified. MSY1 maintains ,99% virtual heterozygosity despite the absence of interallelic processes on the haploid and non-recombining Y chromosome. This thesis aimed to determine the types and rates of mutation events that were occurring at MSY1. Single-molecule analysis was used to analyse mutation in the sperm and blood DNA of a single donor. Sperm mutation rate was 2.6%, and mutants were small-scale length changes and isometric mutations that alter the internal structure of arrays but not array length. Overall mutation rate in blood was similar (1.8%), but the spectrum of mutation types was markedly different, suggesting that somatic and germline mutation processes are distinct. Analysis of MSY1 diversity in the framework of the Y phylogeny defined by binary markers allowed inferences to be made ...
They say opposites attract, and somehow even the wildly different X and Y chromosomes are able to pair up during sperm formation. New research shows how complex that process is, and it pinpoints a step in the process that can go awry, leading to sex-chromosome diseases or infertility.
How did the human Y chromosome become so small relative to its X counterpart? This animation depicts the 300-million-year odyssey of the sex chromosomes that began when the proto X and Y were an...
Stuart S. Howards, MD will serve as the AXYS treasurer. He is a professor emeritus at UVAs Medical School & a professor of urology at Wake Forest.
Men may not become extinct after all, according to a new study. Previous research has suggested the Y sex chromosome, which only men carry, is decaying genetically so fast that it will be extinct in five million years time. A gene within the chromosome is the switch which leads to testes development and the secretion of male hormones. But a new U.S. study, published in Nature suggests the genetic decay has all but ended.. The domsday predictions were based on comparisons between the human X and Y sex chromosomes. While these chromosomes were once thought to be identical far back in the early history of mammals, the Y chromosome now has about 78 genes, compared with about 800 in the X chromosome.. ...
The genus Tokudaia comprises three species, two of which have lost their Y chromosome and have an XO/XO sex chromosome constitution. Although Tokudaia muenninki (Okinawa spiny rat) retains the Y chrom
Yes, the Y chromosome separates the guys from the gals, but scientists didnt think it was good for much else. New research indicates that in humans the Y includes a set of multitasking genes that regulate cells throughout the male body.
Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY
The Y chromosome is the male sex chromosome in mammals, and is paired with an X chromosome in males. It is found in every cell of the body except red blood cells, which have no chromosomes.. ...
Modern men have no traces of Neanderthal DNA on their Y chromosome, the first-ever analysis of the male Neanderthal sex chromosome has revealed
Male mice are able to reproduce healthy offspring with only two Y-chromosome genes, researchers at the University of Hawaii have discovered.. Does this mean that the Y chromosome (or most of it) is no longer needed? Yes, given our current technological advances in assisted reproductive technologies, said Professor Monika Ward at the Institute for Biogenesis Research.. Ward and her colleagues produced transgenic mice that only had the Sry gene, critical in testes development, and the Eif2s3y gene, which is involved in the initial stages of sperm production, on their Y chromosomes.. These infertile mice then underwent an advanced form of IVF, called spermatid injection, where immature sperm cells are injected directly into the egg. They fathered pups that went on to have a normal lifespan and were capable of producing a second generation on their own without further assistance.. Professor Ward highlighted the importance of the Y chromosome for normal, unassisted fertilisation and other aspects ...
Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent …
In the beginning, there was mitochondrial Eve--a woman who lived in Africa between 100,000 and 200,000 years ago and was ancestral to all living humans. Geneticists traced her identity by analyzing DNA passed exclusively from mother to daughter in the mitochondria, energy-producing organelles in the cell. Scientists have been searching ever since for "Adam," the man whose Y chromosome was passed on to every living man and boy. Now two international teams have found the genetic trail leading to Adam--and it points to the same time and place where mitochondrial Eve lived. Described this month at a symposium on human evolution at Cold Spring Harbor Laboratory in New York, the genetic trail is so clear that it allows researchers to compare the migration patterns of men and women tens of thousands of years ago (see sidebar). ...
USDA scientists have found that one reason why some beef cows may not be getting pregnant is they have fragments of male Y chromosome in their DNA.