INTRODUCTION: Adipose tissue blood flow (ATBF) increases after meal intake and a failure to regulate ATBF in the postprandial period seems to be a feature of insulin resistance and obesity. ATBF can be measured quantitatively by the (133)Xe washout technique, but the microdialysis ethanol escape method has also been employed to detect relative changes in ATBF. METHODS: We compared (133)Xe washout and the recovery of exogenous ethanol and endogenous urea by microdialysis in abdominal subcutaneous adipose tissue, after physiological stimulation of ATBF by ingestion of oral glucose (75 g) in eight healthy people (age 23-52 y, body mass index (BMI) 19.4-29.6 kg/m(2)). RESULTS: The ATBF response was heterogeneous. In subjects responding vigorously to the stimulus as measured by (133)Xe washout, the microdialysis ethanol escape was increased (indicating an increase in ATBF). An increased recovery of urea was observed, also indicating an increase in ATBF. The recovery of both small molecules was delayed
Measurements of regional cerebral blood flow (rCBF), analysis ofcerebrospinal fluid, auditory brain stem responses (ABR) andoculomotor tests
Regional cerebral blood flow was measured by the 133Xe inhalation technique in patients with unilateral carotid occlusion, unilateral carotid occlusion and contralateral carotid stenosis, bilateral carotid occlusion, or normal arteriograms. After adjusting for age, sex, and history of stroke, hemisp...
TY - JOUR. T1 - Brain blood flow by radioxenon tomography. AU - Stokely, E. M.. AU - Bonte, F. J.. AU - Devous, M. D.. AU - Arora, G.. PY - 1988. Y1 - 1988. UR - http://www.scopus.com/inward/record.url?scp=0023691961&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023691961&partnerID=8YFLogxK. M3 - Article. C2 - 3263481. AN - SCOPUS:0023691961. VL - 29. SP - 1875. EP - 1876. JO - Journal of Nuclear Medicine. JF - Journal of Nuclear Medicine. SN - 0161-5505. IS - 11. ER - ...
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiofysik. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Radiofysikavdelningen. ...
It is not possible to dissect out the individual components of affinity and intrinsic efficacy from the IRA value; it is only possible to measure their product. However, this limitation is mitigated by two significant points: 1) whereas measurements of affinity and intrinsic efficacy are somewhat cumbersome and not widely tackled, the estimation of IRA only requires the measurement of a concentration-response curve; and 2) a considerable amount of pharmacology occurs at low levels of stimulus, and under these conditions, the behavior of an agonist is governed entirely by the product of its affinity and intrinsic efficacy. This concept can be appreciated by taking the limit of the stimulus function as the agonist concentration approaches zero (see eq. 2). It can be shown that this limit is equal to the product of the agonist concentration and the expressionεR T /K D. This latter expression is equivalent to the initial slope of the stimulus function for the agonist. When this slope is normalized ...
Genetic variation in the response to drug treatment, deteriorating within-host environment and post-treatment recrudescence. (A) Parasite clearance curves for t
Biomarkers have the potential to aid in the study of Alzheimer’s disease (AD); unfortunately, AD biomarker values often have a high degree of overlap between healthy and AD individuals. This study investigates the potential utility of a series of novel AD biomarkers, the sixty second 129Xe retention time, and the xenon washout parameter, based on the washout of hyperpolarized 129Xe from the brain of AD participants following inhalation. The xenon washout parameter is influenced by cerebral perfusion, T1 relaxation of xenon, and the xenon partition coefficient, all factors influenced by AD. Participants with AD (n = 4) and healthy volunteers (n = 4) were imaged using hyperpolarized 129Xe magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to determine the amount of retained xenon in the brain. At 60 s after the breath hold, AD patients retained significantly higher amounts of 129Xe compared to healthy controls. Data was fit to a pharmacokinetic model and the xenon washout
This study sought to determine the degree of agreement between asymmetries of neuropsychological functioning and nine methods of quantifying asymmetries of regional cerebral blood flow.. The regional cerebral blood flow methods combined three markers of cerebral blood flow asymmetry (percent hemispheric difference, maximum percent probe-pair asymmetry, and number of probe-pair asymmetries) with three indexes of regional cerebral blood flow (fast compartment flow, initial slope index, and initial slope). Eleven patients with left hemispheric ischemic strokes and 13 with right hemispheric ischemic strokes were studied with the xenon-133 inhalation technique and neuropsychological tests.. Blind clinical judgments of neuropsychological asymmetry significantly correlated with all nine methods of cerebral blood flow asymmetry determination; correlations ranged from -0.42 to -0.77. Clinical judgment of asymmetry of neuropsychological functioning accurately predicted the hemisphere of lower flow in ...
Measurements of cerebral blood flow (CBF) were performed using the microsphere technique in non-human primates (baboons) to assess the effect of non-radioactive xenon gas inhalation on CBF. Blood flows in small tissue volumes (approximately 1 cm3) were directly measured before and during the inhalation of xenon/oxygen gas mixtures. The results of these studies demonstrated that when inhaled in relatively high concentrations, xenon gas does increase CBF, but the changes are more global than tissue-specific. The problems and limitations of such evaluations are discussed. ...
Lung Scans (Perfusion and Ventilation studies) answers are found in the Daviss Lab & Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Radioactive nuclides as 131I and 133Xe are increasingly used for both clinical diagnosis and therapeutic treatment of the patient. For example, 131I is used for the treatment of thyroid gland cancer. Otherwise, 133Xe is used in ventilation studies to assess and evaluate pulmonary function and to provide images of the lungs in both cardiac and pulmonary diseases, such as asthma, pulmonary emphysema, bronchiectasis, carcinoma of the lung, and pulmonary embolism [1,2]. Furthermore, cerebral blood flow is measured using 133Xe inhalation. In this study, the X and γ-rays emission probabilities in the decay of 131I and 133Xe were precisely measured with a calibrated Si(Li) detector. Results of this study were compared using available results in the literature. Good agreement was observed between our results and available results in the literature.
The article centers around a fascinating case report of a patient who had suffered from PTSD for 8 years and who, after receiving the course of treatment with xenon-augmented memory reconsolidation, was reported to have a complete recovery from symptoms of this devastating disease. The article then describes the rationale for the proposed treatment and provides the review of literature that substantiates this approach.. ...
1. The segmented thermal clearance probe is a noninvasive instrument which measures heat thermal clearance, a variable directly proportional to superficial blood flow, with a depth sensitivity theoretically proportional to the sensor diameter. We compared an 18 mm sensor and a recently developed 57 mm sensor with the reference technique of xenon washout.. 2. The theoretical depth sensitivity of the sensors was assessed using Perspex spacers. Ninety-five per cent of sensitivity had been lost at the respective depths of 3.5 mm and 7.1 mm for the 18 mm and 57 mm sensors.. 3. A comparison was made between heat thermal clearance reading and 133Xe decay curves using the two probes for 15 min after injection of 133Xe at 2 mm and 6 mm depths in the anterior thigh in 41 subjects. The 57 mm sensor showed similar correlation with xenon washout at 2 mm injection depth (r = 0.89) and 6 mm injection depth (r = 0.86), whereas the 18 mm sensor showed greater correlation at 2 mm (r = 0.92) than at 6 mm (r = ...
List of Tables and Figures Figure Automotive Xenon Lamp Product Picture Table Automotive Xenon Lamp Key Market Segments in This Study Table Key Manufacturers Automotive Xenon Lamp Covered in This Study Table Major Manufacturers Automotive Xenon Lamp Sales to top 10 OEMs in 2017 (Supply Relationship) Table Global Automotive Xenon Lamp Market Size Growth Rate by Type 2018-2025 (K Units) & (Million US$) Figure Global Automotive Xenon Lamp Production Market Share 2013-2025 Figure Double Bulb Product Picture Table Major Manufacturers of Double Bulb Figure Single Bulb Product Picture Table Major Manufacturers of Single Bulb Table Global Automotive Xenon Lamp Market Size Growth Rate by Application 2018-2025 (K Units) Figure Civilian Vehicle Figure Commercial Vehicle Figure Others Figure Automotive Xenon Lamp Report Years Considered Figure Global Automotive Xenon Lamp Revenue 2013-2025 (Million US$) Figure Global Automotive Xenon Lamp Production 2013-2025 (K Units) Table Global Automotive Xenon Lamp ...
Placement of doors and windows in a studyroom is as important as the type of doors or windows one uses. Read articles explaining how to effectively use the door and window location to maximize ventilation.
Parkinsons disease is a slowly progressive degenerative neurologic disorder affecting the brain center that are responsible for control and regulation of movement. The degenerative or idiopathic form of Parkinsons disease is the most common; there is also a secondary form with a known or suspected cause. The cause of the disease is mostly unknown. The […]. Read more ...
Thats what I suspected. The hypothetical sample started out with the number of decays being dominated by the short-lived isotope, so the initial slope reflects the shorter half-life. After most of the short-lived isotope has decayed, the decays observed are mostly from the long-lived isotope, so the second slope reflects the longer half-life ...
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SCHNEIDER-KREUZNACH XENON 1,9/50 mount LEICA M2 M3 M4 M5 M6 coupled rangefinder - EUR 180,00. For sale a Schneider Kreuznach lens, the XENON 1,9/50mm, last version, from Retina reflex and now with adapter for LEITZ LEICA M mount with coupling rangefinder. See photos. Clean conditions with a few signs of moderate use on lens barrel. Lens clean with light cleaning signs, but no dust, haze, fungus. Focusing perfect, mild and fluid up to 90 cm. Naturally this XENON fits also on KODAK RETINA reflex and similar cameras, always with excellent result as on Leica M. 122864601082
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Xenon is an element that exists as a gas at most temperatures and is not very reactive. This lesson looks at some general information about xenon,...
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http://www.anandtech.com/video/showdoc.aspx?i=2461 Right now, from what we ve heard, the real-world performance of the Xenon CPU is about twice that...
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Ok.... Ive read all the posts that a search returned and am pretty sure I agree with one. Stating the sidelights if you have xenons are NOT...
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Cerebral blood flow measurements in subarachnoid haemorrhage with an intravenous isotope technique: methodological studies : the significance of cerebral blood flow determinations in the timing of surgery of arterial aneurysm ...
The goal of this study was to determine if regional cerebral blood flow (rCBF)in the left and right hemithalami or the left and right heads of the cau
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimers disease. The study is designed to be conducted in 2 parts in participants with mild to moderate Alzheimers disease, and participants with normal cognition. Various imaging studies will be done using magnetic resonance imaging (MRI) and positron emission tomography (PET) along with neurocognitive assessments. Participants who meet the study-entry criteria will have up to 8 study visits. Repeat imaging studies may be required if the initial data are incomplete or un-interpretable. The maximum number of PET scans during the study will be limited to four ...
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimers disease. The study is designed to be conducted in 2 parts in participants with mild to moderate Alzheimers disease, and participants with normal cognition. Various imaging studies will be done using magnetic resonance imaging (MRI) and positron emission tomography (PET) along with neurocognitive assessments. Participants who meet the study-entry criteria will have up to 8 study visits. Repeat imaging studies may be required if the initial data are incomplete or un-interpretable. The maximum number of PET scans during the study will be limited to four ...
Objective. We introduce the use of 99mTc-hydroxymethylene diphosphonate (HDP) digital blood flow scintigraphy to diagnose Raynauds phenomenon (RP).. Methods. Fifty-seven patients with RP and 60 healthy controls were recruited. One hand was chilled by immersion into water at 4°C, and then an intravenous bolus of 740 MBq of 99mTc-HDP was injected. The radioactivity from the second to the fifth fingers of both hands was recorded. Acquisition was performed at a rate of one frame per 2 seconds until 155 frames. We calculated 4 ratios by comparing the activity curves of the chilled hand with those of the ambient hand.. Results. The chilled to ambient hand ratio of the initial slope was significantly lower in the patients with RP (0.28 ± 0.18) than in the controls (0.78 ± 0.20) (p , 0.001). The chilled to ambient hand ratio of the first peak height, 30-second area under the curve, and blood pool uptake were also lower in the patients with RP than in controls (p , 0.001 for each). The initial slope ...
article{412594, abstract = {Impulsive aggression in dogs has an important impact on human public health. Better insight into the pathophysiology of this phenomenon could lead to more adequate diagnosis and treatment. Indirect in vivo research on peripheral body fluids and post-mortem studies in impulsive animals and humans indicate a deficient serotonergic system in general and disturbances in the serotonin-2A (5-HT2A) receptor in particular. In this study, brain perfusion and the 5-HT2A receptors were examined in impulsive, aggressive dogs, in comparison with a group of normally behaving animals. In order to decide which dogs to include in this study, owners were asked to describe the general behaviour of the dogs, the circumstances in which aggression occurred and their conduct during aggressive acts. Finally, 19 dogs were retained for this study, showing, according to different behavioural specialists, disinhibited dominance aggression. Functional imaging studies were performed on all these ...
Compartmental localization is defined as the placement of a radiopharmaceutical in a fluid space and maintaining it there long enough to image that fluid space. Since a fluid is defined as a liquid or a gas, the airways of the lungs qualify as a fluid space. The use of Xe-133 gas, Xe-127 gas, or Kr-81m gas as a ventilation agent is therefore a good example of this mechanism. Immediate distribution is to the lungs; since Xe-133 is lipophilic and can cross cell membranes, the gas passively diffuses into pulmonary capillaries and the activity is circulated through the blood stream, permitting cerebral blood flow studies. The tbiol of all these gases in the lungs is ,0.5 min in most patients. Ultimately the activity is cleared from the body through the lungs. Another example of compartmental localization is blood pool imaging using autologous Tc-99m labeled red cells or Tc-99m Human Serum Albumin within the blood pool. The immediate distribution is within the blood pool; ultimately the Tc-99m ...
JNeurosci Print ISSN: 0270-6474 Online ISSN: 1529-2401. The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturers claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.. ...
The unique design of the ALBION study with multiple sampling time points similar to a phase 1 study, allowed us to study the relationship between the onset and the magnitude of effect. The definition of slow response comes from a mechanistic model validated in healthy volunteers after a 300-mg clopidogrel LD (24). This model showed that an initial slope of ΔMPA ≤20%/h (defined as slow response) was associated with clopidogrel nonresponse (defined as ΔMPA ,15% at 4, 5, or 24 h) and was strongly correlated with ΔMPA ,15% at 1 h or less. The rate of slow responders to clopidogrel was 46% (median 8%/h decrease rate in MPA, with 75% of them being low responders), whereas a median 33%/h decrease rate in MPA was found in the 54% of fast responders. Fifty-five percent of slow responders (using a more restrictive and easier threshold of 10% ΔMPA with 2 time points of 1 h or less) confirm these results in ACS patients, with slightly lower rates of decrease in MPA in both groups (fast and slow ...
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