The salivary protein, statherin, plays an important role in enamel homeostasis. It forms a bioactive complex with calcium and phosphate releasing these ions when pH decreases. Statherin also forms part of the enamel pellicle forming a protective barrier against bacterial and dietary acids. The purpose of this thesis was two-fold: firstly, to study the effect of a 21 amino acid peptide identical to the N terminus of Statherin (StN21) on enamel de - and remineralisation in vitro and secondly, to undertake biocompatibility assays of this peptide to demonstrate its safety for use in a clinical trial. X-ray microtomography (XMT) is a quantitative, non-destructive method of measuring mineral change. Using XMT to quantify mineral changes, StN21 demonstrated a statistically significant decrease in demineralisation rate when compared to control lesions exposed to phosphate buffered saline (PBS). Whole Statherin protein and sodium fluoride solutions were used as positive controls and were found to have ...
Comparison of synchrotron radiation and conventional X-ray microcomputed tomography for assessing trabecular bone microarchitecture of human femoral ...
Thoracic imaging for small animals has emerged as an important tool for monitoring pulmonary disease progression and therapy response in genetically engineered animals. Micro-CT is becoming the standard thoracic imaging modality in small animal imaging because it can produce high-resolution images of the lung parenchyma, vasculature, and airways. Segmentation, measurement, and visualization of the airway tree is an important step in pulmonary image analysis. However, manual analysis of the airway tree in micro-CT images can be extremely time-consuming since a typical dataset is usually on the order of several gigabytes in size. Automated and semi-automated tools for micro-CT airway analysis are desirable. In this paper, we propose an automatic airway segmentation method for in vivo micro-CT images of the murine lung and validate our method by comparing the automatic results to manual tracing. Our method is based primarily on grayscale morphology. The results show good visual matches between ...
Lizard (Leiocephalus sp.) micro-CT scan. This is the type specimen for this species. Types are the original example against which all descriptions are compared. Types are therefore both scientifically valuable and in demand from researchers wishing to study them. Micro-CT was used to create a virtual copy of this type specimen to help build a digital collection. This image was acquired using X-ray micro-Computed Tomography (also known as micro-CT). A micro-CT scanner projects a beam of X-rays through the sample onto a detector panel. Images are collected over a 360° rotation and these are then reconstructed to form a virtual 3D model of the specimen. This virtual object that can be viewed from all angles and sliced open or digitally dissected. Image by Dan Sykes. - Stock Image C021/7082
The latest Paper of the Month from is X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging by James D. B. OSullivan, Julia B
6. References. 1 Dewidar MM, Khalil KA, Lim JK. Processing and mechanical properties of porous 316L stainless steel for biomedical applications. Transactions of Nonferrous Metals Society of China. 2007;17(3):468-473. [ Links ] 2 Bender S, Chalivendra V, Rahbar N, El Wakil S. Mechanical characterization and modeling of graded porous stainless steel specimens for possible bone implant applications. International Journal of Engineering Science. 2012;53:67-73. [ Links ] 3 Eriksson M, Andersson M, Adolfsson E, Carlström E. Titanium-hydroxyapatite composite biomaterial for dental implants. Powder Metallurgy. 2006;49(1):70-77. [ Links ] 4 Rack HJ, Qazi JI. Titanium alloys for biomedical applications. Materials Science and Engineering: C. 2006;26(8):1269-1277. [ Links ] 5 Oksiuta Z, Dabrowski JR, Olszyna A. Co-Cr-Mo-based composite reinforced with bioactive glass. Journal of Materials Processing Technology. 2009;209(2):978-985. [ Links ] 6 Dourandish M, Godlinski D, Simchi A, Firouzdor V. Sintering of ...
2016 Elsevier B.V. Gas permeability (k) and porosity (f) are the most important parameters in CBM/ECBM and CCS in deep unmineable coal seams. k and f depend on the coal microstructure, and k and f significantly change with varying effective stress. However, how the coal microstructure is related to such permeability and porosity changes is only poorly understood. We thus imaged sub-bituminous coal samples at two resolutions (medium - 33.7 µm and high - 3.43 µm voxel size) in 3D with an x-ray micro-computed tomography as a function of applied effective stress; and investigated how cleat morphology, k and f are influenced by the changes in effective stress and how these parameters are interrelated. In the images, three phases were identified: microcleats (void), a mineral phase (carbonate) and the coal matrix. When effective stress increased, the cleats became narrow and closed or disconnected. This resulted in a dramatic permeability drop with increasing effective stress, while porosity ...
TY - GEN. T1 - Comparison of Early-stage Immobilization and Estrogen-deficiency Induced Bone Loss in Rats Assessed by In Vivo Micro-CT. AU - Brouwers, J.E.M.. AU - Rietbergen, van, B.. AU - Huiskes, R.. PY - 2007. Y1 - 2007. M3 - Conference contribution. SP - T462-. BT - 29th Annual meeting of the ASBMR. CY - United States, Honolulu. ER - ...
Bruker microCT can genuinely claim to be at the fore-front of the development of high performance micro-CT technology. Our research and development of 3D x-ray microscopy started in the early 1980s. This led to the first micro-CT imaging results being obtained in 1983-1987 and published in scientific journals and international conferences proceedings. Building on this early work, Bruker-microCT was founded in 1996, and within a year we were manufacturing a commercially available micro-CT scanner with spatial resolution in the micron range. In 2001 we produced the first high-resolution in vivo micro-CT scanner for small animal imaging. And in 2005 Bruker-microCTbecame the worlds only supplier of a laboratory nano-CT scanner with submicron spatial resolution. Responding to demand from the growing community of micro-CT users, we are continually active in research and development into new methods for non-destructive 3D microscopy. ...
Wilujeng, Indrawati and Santosa, Bagus Jaya 3D SEISMIC TOMOGRAPHY ANALYSIS OF JAPAN SUBSTRUCTURE USING LOCAL EARTHQUAKE TOMOGRAPHY. Proceeding of International Conference On Research, Implementation And Education Of Mathematics And Sciences 2015. ISSN 978-979-96880-8-8 ...
High-resolution micro computed tomography has enabled measurement of bone architecture derived from 3D representations of cancellous bone. Twenty-eight vertebral bodies were obtained from four embalmed male cadavers. From 3D anaglyphs, trabecular rod thickness and length were measured and the trabecular rod Buckling index was calculated. From 3D voxel-based datasets, bone volume density, trabecular thickness, and trabecular separation were measured. Also, trabecular bone pattern factor, structural model index, connectivity density, and degree of anisotropy were calculated. Bone volume density alone explains 59% of the variability in trabecular rod Buckling index. The addition of connectivity density, trabecular separation, and structural model index, in a multiple regression statistical model, improves the explanatory power to 77%. The relationships between measures of cancellous bone architecture and a derived measure of trabecular rod strength were investigated. Morphological descriptors of cancellous
microstructure; acoustic emission AE; rebound hammer; service life of a structure; horizontal casting; precipitation; natural frequency; reinforced concrete chimney; diagnostic; moisture safety; adhesion assessment; gantry crane; stress wave; materials research; acoustic methods; SEM-EDS analysis; SilverSchmidt; reinforced concrete grandstand stadium; concrete strength; autoclaved aerated concrete (AAC); concrete elements; reinforced concrete tanks; degree of degradation; fatigue tests; X-ray micro-computed tomography; GPR method; defects; singular value truncation; ultrasonic tomography; cement-based composites; SEM; moisture of AAC; sulphate corrosion; damage; strengthening; masonry structures; eddy-current method; non-destructive evaluation; non-destructive testing; NDT methods; Structural Health Monitoring; mercury intrusion porosimetry; temperature; vibration analysis; cesium; rebar location; nanoindentation; monitoring of structures; RMF technique; machine learning; lead; viscoelastic ...
Gypsum dehydration as a pore pressure diffusion process - insights from time-series Synchrotron X-ray microtomography, thermodynamic analysis and finite element modelling ...
For those who havent heard or read the story, its probably a little difficult to see the connection between dental research, X-ray science, and the Morecambe and Wise show.. Since the early 90s, I have been working on the design and application of X-ray microtomography (XMT) scanners, which are essentially microscopic forms of medical CT scanners. XMT differs from its full-size medical counterpart in that it is only used to scan small inanimate specimens (from millimetres to a few centimetres), it takes longer, and whereas with medical CT the X-ray system rotates about the patient, with XMT it is the specimen that rotates. In dentistry, we use XMT in research, where we can scan extracted human teeth and precisely map the mineral concentration in three dimensions. This enables us to study the way that teeth lose mineral under acid attack, and where possible, test experimental methods of reversing the process. Although most of the focus of our facility is on tooth and bone samples, we are often ...
TY - JOUR. T1 - Capillary trapping in sandstones and carbonates. T2 - dependence on pore structure. AU - Tanino, Yukie. AU - Blunt, Martin J.. PY - 2012/8. Y1 - 2012/8. N2 - Residual non-wetting phase saturation and wetting-phase permeability were measured in three limestones and four sandstones ranging in porosity from 0.13 to 0.28 and in absolute permeability from 2 × 10-15 to 3 × 10-12 m2. This paper focuses on the residual state established by waterflooding at low capillary number from minimum water saturation achieved using the porous plate technique, which yields the maximum residual under strongly water-wet conditions. The pore coordination number and pore body-throat aspect ratio of each rock were estimated using pore networks extracted from X-ray microtomography images of the rocks. Residual saturation decreases with increasing porosity, with no apparent difference in magnitude between the limestones and sandstones at a given porosity. Thus intraparticle/intra-aggregate microporosity ...
Abbans-Dessous 47°7.905N, 5°52.533E. Franche-Comté, France. Find: 2015 Jul 25. Classification: Ordinary chondrite (LL6). History: On 25 July 2015, while he was looking for fossils in the Franche-Comté region, geologist Quentin Louis discovered a small black stone in the vicinity of Abbans-Dessous village, and recognized it as a possible meteorite. On 3 August 2015, he contacted Fabien Kuntz, a meteorite hunter living nearby in Besançon, who confirmed the stone was a meteorite. Despite several days of hunting together in the area over the summer 2015, and a notice to the local population, no other stones were found.. Physical characteristics: A single, fully crusted, roughly cubic stone.. Petrography: Microscopic observations on a polished section show a recrystallized chondritic texture with chondrules making most of the volume. Plagioclase to 100 μm. Chromite to 150 μm. The bulk density (bulk volume from X-ray microtomography) is 3.15 g/cm3 in agreement with the average LL value ...
SkyScan produces a wide range of the systems for non-invasive three-dimensional x-ray microscopy and for small animal imaging with spatial resolution in the micron range.
Journal Articles. BROECKHOVEN C, DU PLESSIS A, HUI C. Functional trade-off between strength and thermal capacity of dermal armor: Insights from girdled lizards. Journal of the Mechanical Behavior of Biomedical Materials 2017; 74:189-194.. BROECKHOVEN C, DU PLESSIS A. Has snake fang evolution lost its bite? New insights from a structural mechanics viewpoint. Biology Letters 2017; 13(8):5 pages.. DU PLESSIS A, BROECKHOVEN C, GUELPA A, LE ROUX SG. Laboratory x-ray micro-computed tomography: A user guideline for biological samples. GigaScience 2017; 6(6):Article number gix027, 11 pages.. DU PLESSIS A, YADROITSAVA I, LE ROUX SG, YADROITSEV I, FIERES J, REINHART C, ROSSOUW P. Prediction of mechanical performance of Ti6Al4V cast alloy based on microCT-based load simulation. JOURNAL OF ALLOYS AND COMPOUNDS 2017; 724:267-274.. GEBRU A, BRYDEGAARD M, ROHWER EJ, NEETHLING PH. Probing insect backscatter cross-section and melanization using kHz optical remote detection system. Journal of Remote Sensing 2017; ...
Background: The pathomechanisms of atherosclerosis and vascular remodelling are under intense research. Only a few in vivo tools to study these processes longitudinally in animal experiments are available. Here, we evaluated the potential of micro-CT technology. Methods: Lumen areas of the common carotid arteries (CCA) in the ApoE,sup,-/-,/sup, partial carotid artery ligation mouse model were compared between in vivo and ex vivo micro-CT technique and serial histology in a total of 28 animals. AuroVist-15 nm nanoparticles were used as in vivo blood pool contrast agent in a Skyscan 1176 micro-CT at resolution of 18 μmeter voxel size and a mean x-ray dose of 0.5 Gy. For ex vivo imaging, animals were perfused with MicroFil and imaged at 9 μmeter voxel size. Lumen area was evaluated at postoperative days 7, 14, and 28 first by micro-CT followed by histology. Results: In vivo micro-CT and histology revealed lumen loss starting at day 14. The lumen profile highly correlated (r = 0.79, P,0.0001) ...
Microcomputed tomography (Micro CT) is a high-resolution imaging device, which produces non-destructive 3D images of a biological structure, like a tooth.
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The primary mission of the MicroCT Laboratory is to provide state-of-the-art 3D ex vivo imaging using microCT for both research and teaching. This facility is housed within the School of Veterinary Medicine and includes a state-of-the-art ex vivo desktop cone-beam micro-CT (Scanco Model 40) that is fully shielded. This scanner has a nominal best resolution of 6µm with a real resolution of 9µm and a maximum FOV of 37mm in diameter by 70mm in length. Services can include ex vivo x-ray microCT scanning of specimens measuring no more than 35mm in diameter and 70mm in length. Software is available to provide 3D reconstructions of scanned objects, and quantify bone architecture and density. The specimens utilized for microCT must have inherent radio opacity (e.g. bone) or can be rendered radio-opaque (e.g. utilizing contrast agents). Some examples of applications of microCT include evaluation of bone microarchitecture in normal and pathogenic states (e.g. fracture healing, defect healing, in the ...
Micro-Computed Tomography is based on the interaction between the radiation and the material (according to the Beer-Lambert law). In other words, the radiation transmitted is the information captured by a detection system in image form (radiography). In this manner, a slice of material within a solid can be described, based on the different images taken at various different angles. During the tomographic reconstruction process, the main objective is to reconstruct an object that is considered as a 2D distribution of some type of function μ(x,y), which represents the attenuation coefficient of the object in question. The reconstruction of the object is obtained by resolving a mathematical problem, generally implemented in several packages of software.. This reconstruction process makes it possible to easily obtain a volumetric representation of the object, enabling the study and evaluation of different parameters thereof (for example: dispersion of particles, detection of defects, density ...
Alzheimers Disease (AD) is a major concern for the elderly population, currently affecting over 670,000 people in the UK. With the continual increase in the age of the population the problem is expected to rise. There is no known cure to the condition and a definite diagnosis cannot be made in life. Clinical diagnosis is considered to be approximately 80% - 90% accurate, sometimes taking up to a year to assess. Early detection could aid in the care and possible development of better treatments or even a cure. AD has been shown to alter the structure and global texture of the brain. Studies using Magnetic Resonance imaging (MRI) and Computerised Tomography (CT) have been used to detect these changes with some success by some researchers. Positron Emission Tomography (PET) imaging is a functional imaging modality and in theory before structural changes are evident functional changes should be apparent. Therefore we utilise PET images for this study. This thesis will exploit the fact that AD ...
On the right, the concentration depth profile performed along the analysis direction (depth direction) clearly reveals differences between the interfaces (dissymmetrical interfaces): the Fe/TbCo2 interface (1nm thick) is thinner than the Fe/Co interface. This effect is attributed to Fe/Co interdiffusion controlled by the establishment of the Tb layer ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Historically researchers apply time consuming step serial sectioning and subsequent staining and imaging using light microscopy to analyse the lung morphometry. The data obtained using histology is limited to 2D and, as the pathology is often patchy, the results can be biased and incomplete due to heterogeneous pathological phenotypes. Obtaining an overall status of the entire lung is crucial for reliable and complete data. For instance, when screening the lung for metastasis: these can easily be missed when only a few cross sections are made ...
What is the little thing you can do to increase reproducibility, replicability and trust in science? How can reporting quality interfere with reproducibility issues and overall trust in science results? With that question in mind, we participated in the Reproducibility, Replicability and Trust in Science conference organised by the Wellcome Genome Campus from 9 to 11.... ...
The Scientific World Journal is a peer-reviewed, Open Access journal that publishes original research, reviews, and clinical studies covering a wide range of subjects in science, technology, and medicine. The journal is divided into 81 subject areas.
Abstract Micro-CT scanning is a non-destructive technique that can provide three-dimensional images of rock pore space at a resolution of a few microns. . However, these greyscale images cannot be directly input into simulators to predict flow prope
Micro-computed tomography (Micro-CT) is an X-ray imaging technique that produces highresolution 3D computerised virtual models of geological specimens based on the X-ray attenuation of different materials in the specimen. The virtual specimens are made up of voxels, the 3D equivalent of pixels, each assigned a gray value based on X-ray absorption. Micro-CT has enormous potential for allowing non-destructive, digital analysis of structure and composition when the mineralogical phases can be digitally separated. However, variation in X-ray flux between scans results in highly variable grayscale values for identical materials. Consequently, materials usually have to be segmented manually, which is subjective, inaccurate, labour-intensive and time consuming. Here we present a protocol and imaging software package that can be used to accurately and precisely extract quantifiable information in a repeatable and objective fashion. The software will allow the separation, visualisation, measurement ...
Fingerprint Dive into the research topics of Architectural changes in subchondral bone and its compliance in response to estrogen and progesterone: A micro-computed tomography study. Together they form a unique fingerprint. ...
The recent Spectre attack first showed how to inject incorrect branch targets into a victim domain by poisoning microarchitectural branch prediction history. In
Micro CT images (click to enlarge) P0 control P0 K14-Cre;Tgfbr2 fl/fl The complete dataset can be downloaded at FaceBase.org. ...
TESCAN is leading global producer and supplier of scanning electron microscopes, focused ion beam scanning electron microscopes and micro-CT solutions.
Bruker Introduces New SkyScan 1272, an Advanced Non-destructive X-Ray 3D Microscope System Enables Nondestructive High-Resolution micro-CT with 200 Megapixel Slices for Visualization of
A New Scientist note (points to PNAS paper):Post-mortems of binge-drinking adolescent monkeys have produced the best evidence yet that heavy drinking at an early age can do lasting damage to the brain. The worst damage was to stem cells destined to become neurons in the hippocampus, the brain area responsible for memory and spatial awareness.
Vertebrate hard tissues first appeared in the dermal skeletons of early jawless vertebrates (ostracoderms) and were further modified in the earliest jawed vertebrates. Fortunately, histological information is usually preserved in these early vertebrate fossils and has thus been studied for more than a century, done so by examining thin sections, which provide general information about the specific features of vertebrate hard tissues in their earliest forms. Recent progress in synchrotron X-ray microtomography technology has caused a revolution in imaging methods used to study the dermal skeletons of early vertebrates. Virtual thin sections obtained in this manner can be used to reconstruct the internal structures of dermal skeletons in three-dimensions (3D), such as vasculature, buried odontodes (tooth-like unites) and osteocytes. Several body scales of early vertebrates have been examined using this imaging method and in situ 3D models of internal structures are created. Andreolepis (an early ...
The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the ea
TY - CONF. T1 - Three-Dimensional Visualisation and Analysis of Feto-Placental Vascular Cast Using Micro-Computed Tomography in A Rat Model. AU - Tongpob, Yutthapong. AU - Xia, Shushan. AU - Chivers, Emily. AU - Mehnert, Andrew. PY - 2019/4. Y1 - 2019/4. N2 - Many studies of the feto-placental vascular structure have utilised a range of two-dimensional (2D) and three-dimensional (3D) imaging techniques including ultrasound, electron microscopy, confocal microscopy and stereological techniques on systematic uniform random sections; and most recently, innovation with X-ray microtomography (micro-CT) with perfusion of radio-opaque compounds. The CT approach has been used to study feto-placental vasculature in mouse [1], rat [2] and human [3]; this approach embodies particular advantages: (i) revealing the 3D structure in high resolution and (ii) permitting multiple rescanning without irreversibly destroying the sample casts. Nevertheless, some challenges with the micro-CT approach still remain: ...
Read Three-dimensional computed tomography analysis of the vascular anatomy of the splenic hilum for gastric cancer surgery, Surgery Today on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
This paper presents a three dimensional image processing strategy that has been developed to quantitatively analyze and correlate the path of a fatigue crack with the lamellar microstructure found in Ti-6246. The analysis is carried out on X-ray microtomography images acquired in situ during uniaxial fatigue testing. The crack, the primary β-grain boundaries and the α lamellae have been segmented separately and merged for the first time to allow a better characterization and understanding of their mutual interaction. This has particularly emphasized the role of translamellar crack growth at a very high propagation angle with regard to the lamellar orientation, supporting the central role of colonies favorably oriented for basal 〈a〉 slip to guide the crack in the fully lamellar microstructure of Ti alloy. - Highlights: • 3D tomography images reveal strong short fatigue crack interaction with α lamellae. • Proposed 3D image processing methodology makes their segmentation possible. • ...
A fast, powerful and stable filter based on combined wavelet and Fourier analysis for the elimination of horizontal or vertical stripes in images is presented and compared with other types of destriping filters. Strict separation between artifacts and original features allowing both, suppression of the unwanted structures and high degree of preservation of the original image information is endeavoured. The results are validated by visual assessments, as well as by quantitative estimation of the image energy loss. The capabilities and the performance of the filter are tested on a number of case studies related to applications in tomographic imaging. The case studies include (i) suppression of waterfall artifacts in electron microscopy images based on focussed ion beam nanotomography, (ii) removal of different types of ring artifacts in synchrotron based X-ray microtomography and (iii) suppression of horizontal stripe artifacts from phase projections in grating interferometry. ...
In this work we fabricated alumina samples by the freeze-casting technique using tert-butanol as the solvent. The prepared materials were examined by scanning electron microscopy and X-ray microtomography. Next, they were coated with sol-gel silica films by dip-coating. Permeability tests were carried out in order to assess the permeation behavior of the materials processed in this study. We observed that the sintering time and alumina loading showed a remarkable effect on both the structural properties and flexural strength of the freeze-cast samples. Nitrogen adsorption tests revealed that the silica prepared in this study exhibited a microporous structure. It was observed that the presence of silica coatings on the alumina surface decreased the CO{sub 2} permeance by about one order of magnitude. Because of the similar kinetic diameters of nitrogen and carbon dioxide, the CO{sub 2}/N{sub 2} system showed a separation efficiency that was lower than that observed for the He/CO{sub 2} and ...
From 5th to 17th February 2017, we organized the training in Analytical Methods in Geology for students of AGH University of Science and Technology from Krakow in the Centre of Education of Slovak Academy of Sciences in Banská Bystrica. AGH management has decided for this external form of education on the basis of positive experiences with our laboratories and a wide range of modern analytical methods. Overall, 24 graduated students of mineralogy, during two one-week courses, got through the intensive theoretical and practical laboratory training in isotope geochemistry, paleolimnologic field methods, X-ray fluorescence spectrometry, X-ray microtomography, microthermometry and geofluids and creation of 3D digital models using terrestrial laser scanner. At the end of the stay, each student prepared the seminar paper on each of analytical method. For its preparation, the students used computers of our library and electronic access to world scientific databases. The training in particular ...
Well-structured soils are generally considered to have bimodal pore structure, including textural pores between soil particles and structural pores between soil aggregates. Bimodal pore structure has previously been inferred indirectly from the soil water retention curve (SWRC) but our understanding of the precise 3-D pore geometry that regulates this curve is limited. The objective of this study was to investigate the bimodal pore structure of a paddy soil under different fertilization regimes using both SWRC and X-ray micro-Computed Tomography (micro-CT), an imaging approach with the aim of comparing the two methods. Undisturbed soil aggregates and soil cores were collected from the surface layer of a long-term unfertilized control (CK), inorganically fertilized (NPK), and organically and inorganically fertilized (NPKOM) paddy soils. The aggregates and cores were scanned using micro-CT and pore structure analyzed. The SWRCs were measured on the same CT-scanned soil cores. Three widely used ...
Curing is generally required to stabilize film coating from aqueous polymer dispersion. This post-coating drying step is traditionally carried out in static conditions, requiring the transfer of solid dosage forms to an oven. But, curing operation performed directly inside the coating equipment stands for an attractive industrial application. Recently, the use of various advanced physico-chemical characterization techniques i.e., X-ray micro-computed tomography, vibrational spectroscopies (near infrared and Raman) and X-ray microdiffraction, allowed new insights into the film-coating structures of dynamically cured tablets. Dynamic curing end-point was efficiently determined after 4 h. The aim of the present work was to elucidate the influence of curing conditions on film-coating structures. Results demonstrated that 24 h of static curing and 4 h of dynamic curing, both performed at 60 degrees C and ambient relative humidity, led to similar coating layers in terms of drug release properties, porosity,
Materials characterization using X-ray imaging has enabled development of advanced composites that will open up new opportunities to improve manufacturing. In order to deploy reinforced materials, such as ceramic matrix composites (CMC), several structures must be accounted for at all times during tensile or compressive loading experiments. In collaboration with DOE imaging facilities, we have investigated data generated at X-ray beamlines for non-destructive three-dimensional characterization of objects. Experiments using X-ray are widely performed in academia and industry including medical imaging, material science, electronics, geology, and others. As a result of joint data exploration, we have developed FibriPy, a computer-aided fiber detector, tracker and analyzer designed to recognize patterns from micro-computed tomography (microCT). FibriPy is a software environment that combines user-friendly dashboards with programmable functions to support the analysis automation of 3D microCT stacks. While
This study evaluated the stress distribution in endodontically treated teeth, weakened (W) or not weakened (NW), restored with different materials of prosthetic crown using 3D-FEA. Models of a maxillary canine were constructed based on micro-CT images and divided into the groups: G1 (control) - sound tooth; G2 to G7 - endodontically treated teeth restored with glass fiber post (GFP); which G2 to G4 simulated NW root and G5 to G7 simulated W root. For crown material the teeth were restored with: G2 and G5: metallic coping and ceramic veneering, G3 and G6: zirconia coping and ceramic veneering, G4 and G7: alumina coping and ceramic veneering ...
Scattered photons highly degrade the quality of X-ray images and their effect has become more important due to the increasing interest in cone-beam geometry for the acquisition of CT (CBCT) and micro-CT data. The random nature of scatter events and the great i Scattered photons highly degrade the quality of X-ray images and their effect has become more important due to the increasing interest in cone-beam geometry for the acquisition of CT (CBCT) and micro-CT data. The random nature of scatter events and the great influence of the sample suggest that the most accurate methods for their estimation are Monte Carlo (MC) techniques, but their use is usually hampered by the large computation time required to obtain an acceptable estimation of the scattered radiation. We present an approach for scatter correction in CBCT by MC estimation, speeding up the computation by means of general purpose graphic processing units (GPGPU) and developing a framework for the automatic correction and reconstruction ...
© 2019 American Society for Surgery of the Hand Purpose: The anatomy of the radial head and capitellum has been extensively studied; however, the anatomy of the radial notch of the ulna (RNU) has received little attention. This imaging-based anatomic study characterizes the morphology of the RNU. Methods: Ninety-eight cadaveric arms (57 male, 72 ± 14 y) were imaged with computed tomography, and 3-dimensional reconstructions of the proximal ulna were constructed. The anteroposterior and proximal-distal dimensions of the RNU as well as the radius of curvature at standardized levels were measured in 2-mm increments. The orientation of the RNU was also determined. Results: The proximal-distal and anteroposterior dimensions of the RNU were 12 ± 2 mm (range, 7-16 mm) and 18 ± 3 mm (range, 12-24 mm), respectively. The average radius of curvature of the RNU was 15 ± 0 mm (range, 15-16 mm). The radius of curvature did not change significantly when comparing the proximal and distal aspect of the RNU. The RNU
In vivo animal testing has demonstrated that REGENESORB material is bioabsorbable and is replaced by bone. Implants (9x10 mm) were implanted in ovine cancellous bone and compared to an empty defect (9x10 mm) at 6, 12, 18, and 24 months (n=6). Micro-CT analysis demonstrated that by 24 months, bone in-growth into this material (289.5 mm3) was significantly greater (p,0.05) than bone in-growth into an empty defect (170.2mm3) and reaches a bone volume not statistically different from intact bone (188.2 mm3). Results of in vivo simulation have not been shown to quantitatively predict clinical performance. Data on file at Smith & Nephew in report 15000897 ...
Journal of Neuro-Ophthalmology keeps pace with important advances in all spheres of the neurologic and ophthalmologic sciences. Clinicians and researchers worldwide report on recent developments in diagnosing and treating ophthalmologic, neurologic, endocrine, inflammatory, and neoplastic conditions affecting the oculomotor and visual systems. The Journal publishes original, peer-reviewed articles on both clinical and basic aspects of neuro-ophthalmology. Other regular features include reviews, Viewpoints, Photoessays, editorials, letters, and special features including interviews, historical vignettes, and NANOS news.
I focus on verification of true bone matrix (or when relevant, cartilage matrix) production, including crosslinked type I collagen in extracellular matrix, separated from the surrounding extracellular fluid by epithelial-like osteoblats. I have particular expertise in analysis of transport by bone of mineral and acid to produce matrix.. Methods include advanced microscopy of bone with and without decalcification, and in some cases electron microscopy. I have and run Bruker micro-CT analysis. I have equipment to make and analyze cell membrane vesicles and vesicle ion transport. I do sections of bone with and without decalcification and analysis of extracellular bone matrix. We run common biochemical methods including quantitative PCR and fluorescent labels for cell preparations, including digital analysis of labeling using inverted fluorescence microscopes. ...
This report describes the first human retrieval of a polycarbonate-urethane (PCU) acetabular cup implanted for 10.5 months that was revised for pain of unknown origin. By using a micro-CT analysis, the articulating surface was determined to have a wear rate of less than 1.4 mm3 per year. An analysis of the synovial fluid retrieved at the time of revision found an average particle size of 1 μm diameter. Overall, the surgical findings and analysis were consistent with the results observed in laboratory and animal studies. The histology and synovial fluid analysis found sparse evidence of particulate debris and no synovitis, indicating the potential of this articulating material for use as a bearing surface.. ...
Abstract Objectives Tubules dominate the microstructure of dentin, and in crowns of human teeth they are surrounded by thick mineralized peritubular cuffs of high stiffness. Here we examine the three-dimensional (3D) arrangement of tubules in relation to enamel on the buccal and lingual aspects of intact premolars and molars. Specifically we investigate the angular orientation…
Edinburgh, Scotland: Proceedings of the Annual Workshop of COST Action FP0802: Micro-characterisation of wood materials and properties , 2012. , 40-41 p. ...
Fibrous structures mimicking the morphology of the natural extracellular matrix are considered promising scaffolds for tissue engineering. This work aims to develop a novel hierarchical starch-based scaffold. Such scaffolds were obtained by a combination of starch-polycaprolactone micro- and polycaprolactone nano-motifs, respectively produced by rapid prototyping (RP) and electrospinning techniques. Scanning electron microscopy (SEM) and micro-computed tomography analysis showed the successful fabrication of a multilayer scaffold composed of parallel aligned microfibres in a grid-like arrangement, intercalated by a mesh-like structure with randomly distributed nanofibres (NFM). Human osteoblast-like cells were dynamically seeded on the scaffolds, using spinner flasks, and cultured for 7…. ...
Micro Photonics Inc. is offering the SkyScan 1272, a benchtop x-ray micro-CT (computed tomography) system from Bruker MicroCT that can nondestructivel
Cover: How other animals see the world has always intrigued us, not least because their eyes are often notably different from ours. In visually mediated decision making, regional specialisations of eyes largely determine the information animals have for critical judgements. Bagheri et al. (jeb210195) present a new method for estimating the spatial resolution of compound eyes, using 3D micro-CT images of preserved animals. This method estimates the way in which a compound eye samples the visual field by mapping the viewing directions of individual photoreceptors (white dots) and calculating spatial resolution in different directions of view. This study reveals that fiddler crabs see the world with two parallel streaks located just above and below the visual horizon. Picture credit: Zahra Bagheri and Jeremy Shaw. ...
Ismael Himar Falcon‐Suarez, Giorgos Papageorgiou, Zhaoyu Jin, Andrea Muñoz‐Ibáñez, Mark Chapman, Angus I. Best (2020). CO2‐Brine Substitution Effects on Ultrasonic Wave Propagation Through Sandstone With Oblique Fractures. 10.1029/2020GL088439. Ben Callow, Ismael Falcon-Suarez, Hector Marin-Moreno, Jonathan M Bull, Sharif Ahmed (2020). Optimal X-ray micro-CT image based methods for porosity and permeability quantification in heterogeneous sandstones. 10.1093/gji/ggaa321. Ismael Himar Falcon-Suarez, Laurence North, Ben Callow, Gaye Bayrakci, Jon Bull, Angus Best (2020). Experimental assessment of the stress-sensitivity of combined elastic and electrical anisotropy in shallow reservoir sandstones. 10.1190/geo2019-0612.1. */ Marcella Dean, Jerry Blackford, Douglas Connelly, Rob Hines (2020). Insights and guidance for offshore CO2 storage monitoring based on the QICS, ETI MMV, and STEMM-CCS projects. 10.1016/j.ijggc.2020.103120. Christoph Böttner, Matthias Haeckel, Mark Schmidt, Christian ...
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Histologic section; Micro-computed tomography (μCT, micro-CT); Quantitative bone morphometry; Bone architecture; Trabecular bone; Iliac ...
Joachim Ohser and Dascha Dobrovolskij of the University of Applied Sciences in Darmstadt, Germany, together with Jorge Lacayo-Pineda of Continental, and Matthew Putman of the imaging company Nanotronics in New York, US, wanted to determine whether a new imaging platform developed by Nanotronics, nSPEC 3D, could offer an alternative, foolproof method of estimating the size distribution. Based on radiometric stereo microscopy, the method involves illuminating a sample with six LEDs around the microscopes objective, pointing inwards at 45°. The six resultant 2D images are combined by a Nanotronics algorithm to produce a 3D, stereoscopic image of the samples surface.. At the ESRF beamline ID19, Ohser could compare the size distribution of filler particles in rubber samples given by nSPEC 3D with that given by the gold standard of 3D tomography, synchrotron microtomography. The application of coherent illumination combined with phase-retrieval techniques [at ID19] allowed 3D image acquisition ...
Joachim Ohser and Dascha Dobrovolskij of the University of Applied Sciences in Darmstadt, Germany, together with Jorge Lacayo-Pineda of Continental, and Matthew Putman of the imaging company Nanotronics in New York, US, wanted to determine whether a new imaging platform developed by Nanotronics, nSPEC 3D, could offer an alternative, foolproof method of estimating the size distribution. Based on radiometric stereo microscopy, the method involves illuminating a sample with six LEDs around the microscopes objective, pointing inwards at 45°. The six resultant 2D images are combined by a Nanotronics algorithm to produce a 3D, stereoscopic image of the samples surface.. At the ESRF beamline ID19, Ohser could compare the size distribution of filler particles in rubber samples given by nSPEC 3D with that given by the gold standard of 3D tomography, synchrotron microtomography. The application of coherent illumination combined with phase-retrieval techniques [at ID19] allowed 3D image acquisition ...
Main bone parameters from analysis: TV (total volume [mm3]), BV (bone volume [mm3]), BV/TV, Tb.Th (thickness of the trabecular structure), Tb.N (number of trabeculae), Tb.Sp (trabecular separation ...
One my images is featured on our OBCD website as Image of the Month. It represents a 3D reconstruction of a mouse femoral trabecular bone micro-CT. The black and white section on the left is the original unaltered reconstruction, the coloured image in the middle represents the trabecular bone thickness, and the bubbly section on the right illustrates spacing in between the trabeculae. ...
It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. The adaptation of ultrasound for imaging murine hearts, for example, has allowed characterization of the developing and adult rodent heart, making it an essential tool for the study of developmental biology and cardiovascular disease. Nevertheless, additional imaging tools may prove useful adjuncts and/or alternatives to such established traditional modalities.. Ideally, a cardiovascular imaging modality should provide structural-functional quantitation and be noninvasive, fast, cost effective, precise, and accurate. Although the combination of echocardiography and small-animal cardiac magnetic resonance has been proven to meet several of these criteria, there is certainly room for other modalities to be used as well. At our institution, experimentation with a micro-computed tomography (CT) scanner eventually produced ...
NEW PRODUCT: SkyScanTM 1278, the worlds fastest, low-dose, high-resolution micro-CT: With the launch of the next-generation SkyScan 1278 micro-CT system for in vivo X-ray computed tomography, Bruker is addressing the latest needs of preclinical imaging scientists striving to reduce the radiation dose used in animal studies, while maintaining highest image quality. As part of the development, Bruker has created a new micro-CT spatial beam shaper, which reduces the absorbed dose by up to five times, while maintaining high quality image output. The SkyScan 1278 has a highly sensitive flat-panel detector that is able to deliver images of mouse heart and lung activities even without a contrast agent. Such images allow the user to explore cardiac and respiratory function, while reducing animal stress and the cost of the study. A full-body animal scan can take 8 seconds or less, reducing run times and increasing the speed of data collection. FIRST CUSTOMER INSTALLATION: Bruker announces the first ...
Video created by Duke University, North Carolina State University, The University of North Carolina at Chapel Hill for the course Nanotechnology: A Makers Course. In this module, we will see demonstrations of micro-computed tomography, X-ray ...
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