The salivary protein, statherin, plays an important role in enamel homeostasis. It forms a bioactive complex with calcium and phosphate releasing these ions when pH decreases. Statherin also forms part of the enamel pellicle forming a protective barrier against bacterial and dietary acids. The purpose of this thesis was two-fold: firstly, to study the effect of a 21 amino acid peptide identical to the N terminus of Statherin (StN21) on enamel de - and remineralisation in vitro and secondly, to undertake biocompatibility assays of this peptide to demonstrate its safety for use in a clinical trial. X-ray microtomography (XMT) is a quantitative, non-destructive method of measuring mineral change. Using XMT to quantify mineral changes, StN21 demonstrated a statistically significant decrease in demineralisation rate when compared to control lesions exposed to phosphate buffered saline (PBS). Whole Statherin protein and sodium fluoride solutions were used as positive controls and were found to have ...
Comparison of synchrotron radiation and conventional X-ray microcomputed tomography for assessing trabecular bone microarchitecture of human femoral ...
Thoracic imaging for small animals has emerged as an important tool for monitoring pulmonary disease progression and therapy response in genetically engineered animals. Micro-CT is becoming the standard thoracic imaging modality in small animal imaging because it can produce high-resolution images of the lung parenchyma, vasculature, and airways. Segmentation, measurement, and visualization of the airway tree is an important step in pulmonary image analysis. However, manual analysis of the airway tree in micro-CT images can be extremely time-consuming since a typical dataset is usually on the order of several gigabytes in size. Automated and semi-automated tools for micro-CT airway analysis are desirable. In this paper, we propose an automatic airway segmentation method for in vivo micro-CT images of the murine lung and validate our method by comparing the automatic results to manual tracing. Our method is based primarily on grayscale morphology. The results show good visual matches between ...
Lizard (Leiocephalus sp.) micro-CT scan. This is the type specimen for this species. Types are the original example against which all descriptions are compared. Types are therefore both scientifically valuable and in demand from researchers wishing to study them. Micro-CT was used to create a virtual copy of this type specimen to help build a digital collection. This image was acquired using X-ray micro-Computed Tomography (also known as micro-CT). A micro-CT scanner projects a beam of X-rays through the sample onto a detector panel. Images are collected over a 360° rotation and these are then reconstructed to form a virtual 3D model of the specimen. This virtual object that can be viewed from all angles and sliced open or digitally dissected. Image by Dan Sykes. - Stock Image C021/7082
The latest Paper of the Month from is X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging by James D. B. OSullivan, Julia B
6. References. 1 Dewidar MM, Khalil KA, Lim JK. Processing and mechanical properties of porous 316L stainless steel for biomedical applications. Transactions of Nonferrous Metals Society of China. 2007;17(3):468-473. [ Links ] 2 Bender S, Chalivendra V, Rahbar N, El Wakil S. Mechanical characterization and modeling of graded porous stainless steel specimens for possible bone implant applications. International Journal of Engineering Science. 2012;53:67-73. [ Links ] 3 Eriksson M, Andersson M, Adolfsson E, Carlström E. Titanium-hydroxyapatite composite biomaterial for dental implants. Powder Metallurgy. 2006;49(1):70-77. [ Links ] 4 Rack HJ, Qazi JI. Titanium alloys for biomedical applications. Materials Science and Engineering: C. 2006;26(8):1269-1277. [ Links ] 5 Oksiuta Z, Dabrowski JR, Olszyna A. Co-Cr-Mo-based composite reinforced with bioactive glass. Journal of Materials Processing Technology. 2009;209(2):978-985. [ Links ] 6 Dourandish M, Godlinski D, Simchi A, Firouzdor V. Sintering of ...
2016 Elsevier B.V. Gas permeability (k) and porosity (f) are the most important parameters in CBM/ECBM and CCS in deep unmineable coal seams. k and f depend on the coal microstructure, and k and f significantly change with varying effective stress. However, how the coal microstructure is related to such permeability and porosity changes is only poorly understood. We thus imaged sub-bituminous coal samples at two resolutions (medium - 33.7 µm and high - 3.43 µm voxel size) in 3D with an x-ray micro-computed tomography as a function of applied effective stress; and investigated how cleat morphology, k and f are influenced by the changes in effective stress and how these parameters are interrelated. In the images, three phases were identified: microcleats (void), a mineral phase (carbonate) and the coal matrix. When effective stress increased, the cleats became narrow and closed or disconnected. This resulted in a dramatic permeability drop with increasing effective stress, while porosity ...
Bruker microCT can genuinely claim to be at the fore-front of the development of high performance micro-CT technology. Our research and development of 3D x-ray microscopy started in the early 1980s. This led to the first micro-CT imaging results being obtained in 1983-1987 and published in scientific journals and international conferences proceedings. Building on this early work, Bruker-microCT was founded in 1996, and within a year we were manufacturing a commercially available micro-CT scanner with spatial resolution in the micron range. In 2001 we produced the first high-resolution in vivo micro-CT scanner for small animal imaging. And in 2005 Bruker-microCTbecame the worlds only supplier of a laboratory nano-CT scanner with submicron spatial resolution. Responding to demand from the growing community of micro-CT users, we are continually active in research and development into new methods for non-destructive 3D microscopy. ...
Wilujeng, Indrawati and Santosa, Bagus Jaya 3D SEISMIC TOMOGRAPHY ANALYSIS OF JAPAN SUBSTRUCTURE USING LOCAL EARTHQUAKE TOMOGRAPHY. Proceeding of International Conference On Research, Implementation And Education Of Mathematics And Sciences 2015. ISSN 978-979-96880-8-8 ...
Gypsum dehydration as a pore pressure diffusion process - insights from time-series Synchrotron X-ray microtomography, thermodynamic analysis and finite element modelling ...
SkyScan produces a wide range of the systems for non-invasive three-dimensional x-ray microscopy and for small animal imaging with spatial resolution in the micron range.
Background: The pathomechanisms of atherosclerosis and vascular remodelling are under intense research. Only a few in vivo tools to study these processes longitudinally in animal experiments are available. Here, we evaluated the potential of micro-CT technology. Methods: Lumen areas of the common carotid arteries (CCA) in the ApoE,sup,-/-,/sup, partial carotid artery ligation mouse model were compared between in vivo and ex vivo micro-CT technique and serial histology in a total of 28 animals. AuroVist-15 nm nanoparticles were used as in vivo blood pool contrast agent in a Skyscan 1176 micro-CT at resolution of 18 μmeter voxel size and a mean x-ray dose of 0.5 Gy. For ex vivo imaging, animals were perfused with MicroFil and imaged at 9 μmeter voxel size. Lumen area was evaluated at postoperative days 7, 14, and 28 first by micro-CT followed by histology. Results: In vivo micro-CT and histology revealed lumen loss starting at day 14. The lumen profile highly correlated (r = 0.79, P,0.0001) ...
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The primary mission of the MicroCT Laboratory is to provide state-of-the-art 3D ex vivo imaging using microCT for both research and teaching. This facility is housed within the School of Veterinary Medicine and includes a state-of-the-art ex vivo desktop cone-beam micro-CT (Scanco Model 40) that is fully shielded. This scanner has a nominal best resolution of 6µm with a real resolution of 9µm and a maximum FOV of 37mm in diameter by 70mm in length. Services can include ex vivo x-ray microCT scanning of specimens measuring no more than 35mm in diameter and 70mm in length. Software is available to provide 3D reconstructions of scanned objects, and quantify bone architecture and density. The specimens utilized for microCT must have inherent radio opacity (e.g. bone) or can be rendered radio-opaque (e.g. utilizing contrast agents). Some examples of applications of microCT include evaluation of bone microarchitecture in normal and pathogenic states (e.g. fracture healing, defect healing, in the ...
Alzheimers Disease (AD) is a major concern for the elderly population, currently affecting over 670,000 people in the UK. With the continual increase in the age of the population the problem is expected to rise. There is no known cure to the condition and a definite diagnosis cannot be made in life. Clinical diagnosis is considered to be approximately 80% - 90% accurate, sometimes taking up to a year to assess. Early detection could aid in the care and possible development of better treatments or even a cure. AD has been shown to alter the structure and global texture of the brain. Studies using Magnetic Resonance imaging (MRI) and Computerised Tomography (CT) have been used to detect these changes with some success by some researchers. Positron Emission Tomography (PET) imaging is a functional imaging modality and in theory before structural changes are evident functional changes should be apparent. Therefore we utilise PET images for this study. This thesis will exploit the fact that AD ...
On the right, the concentration depth profile performed along the analysis direction (depth direction) clearly reveals differences between the interfaces (dissymmetrical interfaces): the Fe/TbCo2 interface (1nm thick) is thinner than the Fe/Co interface. This effect is attributed to Fe/Co interdiffusion controlled by the establishment of the Tb layer ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
The Scientific World Journal is a peer-reviewed, Open Access journal that publishes original research, reviews, and clinical studies covering a wide range of subjects in science, technology, and medicine. The journal is divided into 81 subject areas.
Abstract Micro-CT scanning is a non-destructive technique that can provide three-dimensional images of rock pore space at a resolution of a few microns. . However, these greyscale images cannot be directly input into simulators to predict flow prope
Micro-computed tomography (Micro-CT) is an X-ray imaging technique that produces highresolution 3D computerised virtual models of geological specimens based on the X-ray attenuation of different materials in the specimen. The virtual specimens are made up of voxels, the 3D equivalent of pixels, each assigned a gray value based on X-ray absorption. Micro-CT has enormous potential for allowing non-destructive, digital analysis of structure and composition when the mineralogical phases can be digitally separated. However, variation in X-ray flux between scans results in highly variable grayscale values for identical materials. Consequently, materials usually have to be segmented manually, which is subjective, inaccurate, labour-intensive and time consuming. Here we present a protocol and imaging software package that can be used to accurately and precisely extract quantifiable information in a repeatable and objective fashion. The software will allow the separation, visualisation, measurement ...
Micro CT images (click to enlarge) P0 control P0 K14-Cre;Tgfbr2 fl/fl The complete dataset can be downloaded at FaceBase.org. ...
TESCAN is leading global producer and supplier of scanning electron microscopes, focused ion beam scanning electron microscopes and micro-CT solutions.
Bruker Introduces New SkyScan 1272, an Advanced Non-destructive X-Ray 3D Microscope System Enables Nondestructive High-Resolution micro-CT with 200 Megapixel Slices for Visualization of
A New Scientist note (points to PNAS paper):Post-mortems of binge-drinking adolescent monkeys have produced the best evidence yet that heavy drinking at an early age can do lasting damage to the brain. The worst damage was to stem cells destined to become neurons in the hippocampus, the brain area responsible for memory and spatial awareness.
Vertebrate hard tissues first appeared in the dermal skeletons of early jawless vertebrates (ostracoderms) and were further modified in the earliest jawed vertebrates. Fortunately, histological information is usually preserved in these early vertebrate fossils and has thus been studied for more than a century, done so by examining thin sections, which provide general information about the specific features of vertebrate hard tissues in their earliest forms. Recent progress in synchrotron X-ray microtomography technology has caused a revolution in imaging methods used to study the dermal skeletons of early vertebrates. Virtual thin sections obtained in this manner can be used to reconstruct the internal structures of dermal skeletons in three-dimensions (3D), such as vasculature, buried odontodes (tooth-like unites) and osteocytes. Several body scales of early vertebrates have been examined using this imaging method and in situ 3D models of internal structures are created. Andreolepis (an early ...
The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the ea
Read "Three-dimensional computed tomography analysis of the vascular anatomy of the splenic hilum for gastric cancer surgery, Surgery Today" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
This paper presents a three dimensional image processing strategy that has been developed to quantitatively analyze and correlate the path of a fatigue crack with the lamellar microstructure found in Ti-6246. The analysis is carried out on X-ray microtomography images acquired in situ during uniaxial fatigue testing. The crack, the primary β-grain boundaries and the α lamellae have been segmented separately and merged for the first time to allow a better characterization and understanding of their mutual interaction. This has particularly emphasized the role of translamellar crack growth at a very high propagation angle with regard to the lamellar orientation, supporting the central role of colonies favorably oriented for basal 〈a〉 slip to guide the crack in the fully lamellar microstructure of Ti alloy. - Highlights: • 3D tomography images reveal strong short fatigue crack interaction with α lamellae. • Proposed 3D image processing methodology makes their segmentation possible. • ...
A fast, powerful and stable filter based on combined wavelet and Fourier analysis for the elimination of horizontal or vertical stripes in images is presented and compared with other types of destriping filters. Strict separation between artifacts and original features allowing both, suppression of the unwanted structures and high degree of preservation of the original image information is endeavoured. The results are validated by visual assessments, as well as by quantitative estimation of the image energy loss. The capabilities and the performance of the filter are tested on a number of case studies related to applications in tomographic imaging. The case studies include (i) suppression of waterfall artifacts in electron microscopy images based on focussed ion beam nanotomography, (ii) removal of different types of ring artifacts in synchrotron based X-ray microtomography and (iii) suppression of horizontal stripe artifacts from phase projections in grating interferometry. ...
In this work we fabricated alumina samples by the freeze-casting technique using tert-butanol as the solvent. The prepared materials were examined by scanning electron microscopy and X-ray microtomography. Next, they were coated with sol-gel silica films by dip-coating. Permeability tests were carried out in order to assess the permeation behavior of the materials processed in this study. We observed that the sintering time and alumina loading showed a remarkable effect on both the structural properties and flexural strength of the freeze-cast samples. Nitrogen adsorption tests revealed that the silica prepared in this study exhibited a microporous structure. It was observed that the presence of silica coatings on the alumina surface decreased the CO{sub 2} permeance by about one order of magnitude. Because of the similar kinetic diameters of nitrogen and carbon dioxide, the CO{sub 2}/N{sub 2} system showed a separation efficiency that was lower than that observed for the He/CO{sub 2} and ...
From 5th to 17th February 2017, we organized the training in "Analytical Methods in Geology" for students of AGH University of Science and Technology from Krakow in the Centre of Education of Slovak Academy of Sciences in Banská Bystrica. AGH management has decided for this external form of education on the basis of positive experiences with our laboratories and a wide range of modern analytical methods. Overall, 24 graduated students of mineralogy, during two one-week courses, got through the intensive theoretical and practical laboratory training in isotope geochemistry, paleolimnologic field methods, X-ray fluorescence spectrometry, X-ray microtomography, microthermometry and geofluids and creation of 3D digital models using terrestrial laser scanner. At the end of the stay, each student prepared the seminar paper on each of analytical method. For its preparation, the students used computers of our library and electronic access to world scientific databases. The training in particular ...
Well-structured soils are generally considered to have bimodal pore structure, including textural pores between soil particles and structural pores between soil aggregates. Bimodal pore structure has previously been inferred indirectly from the soil water retention curve (SWRC) but our understanding of the precise 3-D pore geometry that regulates this curve is limited. The objective of this study was to investigate the bimodal pore structure of a paddy soil under different fertilization regimes using both SWRC and X-ray micro-Computed Tomography (micro-CT), an imaging approach with the aim of comparing the two methods. Undisturbed soil aggregates and soil cores were collected from the surface layer of a long-term unfertilized control (CK), inorganically fertilized (NPK), and organically and inorganically fertilized (NPKOM) paddy soils. The aggregates and cores were scanned using micro-CT and pore structure analyzed. The SWRCs were measured on the same CT-scanned soil cores. Three widely used ...
Curing is generally required to stabilize film coating from aqueous polymer dispersion. This post-coating drying step is traditionally carried out in static conditions, requiring the transfer of solid dosage forms to an oven. But, curing operation performed directly inside the coating equipment stands for an attractive industrial application. Recently, the use of various advanced physico-chemical characterization techniques i.e., X-ray micro-computed tomography, vibrational spectroscopies (near infrared and Raman) and X-ray microdiffraction, allowed new insights into the film-coating structures of dynamically cured tablets. Dynamic curing end-point was efficiently determined after 4 h. The aim of the present work was to elucidate the influence of curing conditions on film-coating structures. Results demonstrated that 24 h of static curing and 4 h of dynamic curing, both performed at 60 degrees C and ambient relative humidity, led to similar coating layers in terms of drug release properties, porosity,
Materials characterization using X-ray imaging has enabled development of advanced composites that will open up new opportunities to improve manufacturing. In order to deploy reinforced materials, such as ceramic matrix composites (CMC), several structures must be accounted for at all times during tensile or compressive loading experiments. In collaboration with DOE imaging facilities, we have investigated data generated at X-ray beamlines for non-destructive three-dimensional characterization of objects. Experiments using X-ray are widely performed in academia and industry including medical imaging, material science, electronics, geology, and others. As a result of joint data exploration, we have developed FibriPy, a computer-aided fiber detector, tracker and analyzer designed to recognize patterns from micro-computed tomography (microCT). FibriPy is a software environment that combines user-friendly dashboards with programmable functions to support the analysis automation of 3D microCT stacks. While
This study evaluated the stress distribution in endodontically treated teeth, weakened (W) or not weakened (NW), restored with different materials of prosthetic crown using 3D-FEA. Models of a maxillary canine were constructed based on micro-CT images and divided into the groups: G1 (control) - sound tooth; G2 to G7 - endodontically treated teeth restored with glass fiber post (GFP); which G2 to G4 simulated NW root and G5 to G7 simulated W root. For crown material the teeth were restored with: G2 and G5: metallic coping and ceramic veneering, G3 and G6: zirconia coping and ceramic veneering, G4 and G7: alumina coping and ceramic veneering ...
In vivo animal testing has demonstrated that REGENESORB material is bioabsorbable and is replaced by bone. Implants (9x10 mm) were implanted in ovine cancellous bone and compared to an empty defect (9x10 mm) at 6, 12, 18, and 24 months (n=6). Micro-CT analysis demonstrated that by 24 months, bone in-growth into this material (289.5 mm3) was significantly greater (p,0.05) than bone in-growth into an empty defect (170.2mm3) and reaches a bone volume not statistically different from intact bone (188.2 mm3). Results of in vivo simulation have not been shown to quantitatively predict clinical performance. Data on file at Smith & Nephew in report 15000897 ...
Journal of Neuro-Ophthalmology keeps pace with important advances in all spheres of the neurologic and ophthalmologic sciences. Clinicians and researchers worldwide report on recent developments in diagnosing and treating ophthalmologic, neurologic, endocrine, inflammatory, and neoplastic conditions affecting the oculomotor and visual systems. The Journal publishes original, peer-reviewed articles on both clinical and basic aspects of neuro-ophthalmology. Other regular features include reviews, Viewpoints, Photoessays, editorials, letters, and special features including interviews, historical vignettes, and NANOS news.
This report describes the first human retrieval of a polycarbonate-urethane (PCU) acetabular cup implanted for 10.5 months that was revised for pain of unknown origin. By using a micro-CT analysis, the articulating surface was determined to have a wear rate of less than 1.4 mm3 per year. An analysis of the synovial fluid retrieved at the time of revision found an average particle size of 1 μm diameter. Overall, the surgical findings and analysis were consistent with the results observed in laboratory and animal studies. The histology and synovial fluid analysis found sparse evidence of particulate debris and no synovitis, indicating the potential of this articulating material for use as a bearing surface.. ...
It is becoming increasingly important to assess the amount of adipose tissue (fat) in animals in order to characterize its role in not only obesity, but also various metabolic disorders such as insulin resistance, type 2 diabetes, or cardiovascular diseases. In vivo microCT is a non-invasive technique that allows for repeated measurements in the same animal, making it possible to follow disease progression and treatment effect in a longitudinal manner. Adipose tissue is composed mostly of adipocytes and its role is to store energy in the form of lipids ...
Abstract Objectives Tubules dominate the microstructure of dentin, and in crowns of human teeth they are surrounded by thick mineralized peritubular cuffs of high stiffness. Here we examine the three-dimensional (3D) arrangement of tubules in relation to enamel on the buccal and lingual aspects of intact premolars and molars. Specifically we investigate the angular orientation…
Edinburgh, Scotland: Proceedings of the Annual Workshop of COST Action FP0802: Micro-characterisation of wood materials and properties , 2012. , 40-41 p. ...
Fibrous structures mimicking the morphology of the natural extracellular matrix are considered promising scaffolds for tissue engineering. This work aims to develop a novel hierarchical starch-based scaffold. Such scaffolds were obtained by a combination of starch-polycaprolactone micro- and polycaprolactone nano-motifs, respectively produced by rapid prototyping (RP) and electrospinning techniques. Scanning electron microscopy (SEM) and micro-computed tomography analysis showed the successful fabrication of a multilayer scaffold composed of parallel aligned microfibres in a grid-like arrangement, intercalated by a mesh-like structure with randomly distributed nanofibres (NFM). Human osteoblast-like cells were dynamically seeded on the scaffolds, using spinner flasks, and cultured for 7…. ...
Micro Photonics Inc. is offering the SkyScan 1272, a benchtop x-ray micro-CT (computed tomography) system from Bruker MicroCT that can nondestructivel
Cover: How other animals see the world has always intrigued us, not least because their eyes are often notably different from ours. In visually mediated decision making, regional specialisations of eyes largely determine the information animals have for critical judgements. Bagheri et al. (jeb210195) present a new method for estimating the spatial resolution of compound eyes, using 3D micro-CT images of preserved animals. This method estimates the way in which a compound eye samples the visual field by mapping the viewing directions of individual photoreceptors (white dots) and calculating spatial resolution in different directions of view. This study reveals that fiddler crabs see the world with two parallel streaks located just above and below the visual horizon. Picture credit: Zahra Bagheri and Jeremy Shaw. ...
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Histologic section; Micro-computed tomography (μCT, micro-CT); Quantitative bone morphometry; Bone architecture; Trabecular bone; Iliac ...
Main bone parameters from analysis: TV (total volume [mm3]), BV (bone volume [mm3]), BV/TV, Tb.Th (thickness of the trabecular structure), Tb.N (number of trabeculae), Tb.Sp (trabecular separation ...
One my images is featured on our OBCD website as Image of the Month. It represents a 3D reconstruction of a mouse femoral trabecular bone micro-CT. The black and white section on the left is the original unaltered reconstruction, the coloured image in the middle represents the trabecular bone thickness, and the bubbly section on the right illustrates spacing in between the trabeculae. ...
It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. The adaptation of ultrasound for imaging murine hearts, for example, has allowed characterization of the developing and adult rodent heart, making it an essential tool for the study of developmental biology and cardiovascular disease. Nevertheless, additional imaging tools may prove useful adjuncts and/or alternatives to such established traditional modalities.. Ideally, a cardiovascular imaging modality should provide structural-functional quantitation and be noninvasive, fast, cost effective, precise, and accurate. Although the combination of echocardiography and small-animal cardiac magnetic resonance has been proven to meet several of these criteria, there is certainly room for other modalities to be used as well. At our institution, experimentation with a micro-computed tomography (CT) scanner eventually produced ...
NEW PRODUCT: SkyScanTM 1278, the worlds fastest, low-dose, high-resolution micro-CT: With the launch of the next-generation SkyScan 1278 micro-CT system for in vivo X-ray computed tomography, Bruker is addressing the latest needs of preclinical imaging scientists striving to reduce the radiation dose used in animal studies, while maintaining highest image quality. As part of the development, Bruker has created a new micro-CT spatial beam shaper, which reduces the absorbed dose by up to five times, while maintaining high quality image output. The SkyScan 1278 has a highly sensitive flat-panel detector that is able to deliver images of mouse heart and lung activities even without a contrast agent. Such images allow the user to explore cardiac and respiratory function, while reducing animal stress and the cost of the study. A full-body animal scan can take 8 seconds or less, reducing run times and increasing the speed of data collection. FIRST CUSTOMER INSTALLATION: Bruker announces the first ...
Video created by Duke University, North Carolina State University, The University of North Carolina at Chapel Hill for the course Nanotechnology: A Makers Course. In this module, we will see demonstrations of micro-computed tomography, X-ray ...
Zetec delivers leading nondestructive testing (NDT) solutions that ensure better inspection results for both eddy current & UT technologies. Visit us today.
Jie Tang1 ,Yanjun Li1 ,Jiayuan Xu1 ,Wen Qin1 ,Qian Su2 ,Qiang Xu1 ,Bing Liu3 ,Tianzi Jiang3 ,Chunshui Yu1 1 Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, Peoples Republic of China. 2 School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, Peoples Republic of China. 3 Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, Peoples Republic of China. Abstract. Catechol-O-methyltransferase (COMT) affects brain connectivity via modulating the dopamine system, with an expected greater effect of haplotypes than single-nucleotide polymorphism (SNP). The action pathway from COMT to dopamine to connectivity is theoretically dependent on the gene expression of dopamine receptors. Here, we aimed to investigate the impact of COMT haplotypes on brain functional connectivity density (FCD) in ...
Glucocorticoids (GCs) are effective anti-inflammatory agents commonly used to suppress autoimmune diseases; however, their beneficial effects are countered by the efficiency to which GCs deteriorate bone mineral density. We show here that the molecular mechanisms contributing to this bone loss may be linked to the ability of GCs to suppress the cell cycle, Krox20, and Wnt signaling. GCs inhibit cell cycle progression in primary osteoblast cultures in a developmental- and stage-specific manner attributable to suppression of cyclin A. Analysis of the cyclin A promoter revealed that Atf4 regulates GC-mediated inhibition of cyclin A expression through a Creb/Atf site. In addition to the anti-proliferative effect of GCs, we show that Egr2/Krox20 is required for GC-mediated repression of osteocalcin, an osteoblast specific gene and that Egr family members are down-regulated by GCs. Furthermore, micro-computed tomographic analysis of Krox20 heterozygous mice revealed decreased trabecular bone mineral ...
Also, the second part of table 15 compares the results of our µCT-based FEM analysis for different modelling approaches with experimental data. Since trabecular bone volume fraction significantly affects its Youngs modulus, the values of bone volume fraction for experimental data are also included. The experimental data clearly show an increase in bone modulus with bone volume fraction. Our experimental results compare well with the experimental values reported in literature for trabecular bone of comparable porosity [102]. However, both our modelling and experimental results for Youngs modulus of trabecular bone are on the lower side of the values reported in literature. This might be due to the fact that the specific bone samples used to create the FEM model and to do compression testing were from an old (88-year-old) donor and, consequently, were very porous. Another reason for the poor results of our experimental data may be the systematic errors in the platen compression test of ...
High resolution micro-CT images of porous rocks provide a very useful starting point to the development of pore-scale models of fluid flow and transport. Following a literature review covering recent results on the applicability of tomographic imaging to study reaction phenomena at the pore and core scales, this thesis presents a pore-scale streamline-based reactive transport model to simulate rock dissolution. The focus is on carbonate dissolution in CO2-saturated fluids. After injecting CO2-rich fluids into carbonate reservoirs, chemical reactions between the acidic fluid and the host rock are to be expected. Such reactions may cause significant variations in the flow and transport properties of the reservoir, with possible consequences for field development and monitoring. The interplay between flow and reaction exhibits a very rich behaviour that has not yet been fully understood, especially in the case of carbonate rocks, which possess a complex pore structure. The model is developed within ...
We and others have used pre-clinical ultrasound to visualize cardiac dynamics in developing chick and mouse embryos (Broekhuizen et al.,1999; Phoon,2001; Butcher et al.,2007a). Ultrasound has the advantage of high ungated temporal resolution (over 250 frames/sec), but can also be gated for better resolution. For small animals, information gained is almost exclusively 2D with spatial resolution ∼30-50 μ. Contrast for ultrasound is challenging in embryos, as microbubble size is not negligible in relation to vessel diameter and are challenging to inject (Alter et al.,2009). 3D micro-MRI manipulates intrinsic magnetic properties of tissues to generate contrast and can achieve spatial resolutions less than 20 μ for fixed tissues. In addition, manipulation of electron spins with magnetic stimulation can help improve tissue contrast locally without the need of exogenous dyes. Isotropic voxel size, however, is inversely proportional to the size of the volume interrogated, which limits the ability to ...
Dans la peau de Romundina stellina Ørvig, 1975 (Vertebrata, Placodermi, Acanthothoraci). Anatomie crânienne dun des premiers gnathostomes révélée par tomographie synchrotron en contraste de phase. Being Romundina stellina Ørvig, 1975 (Vertebrata, Placodermi, Acanthothoraci). Intracranial anatomy of one of the deepest gnathostomes revealed by synchrotron tomography in phase contrast protocole. The acanthothoracid placoderms (armored fishes) are the most basal and primitive gnathostomes (jawed vertebrates; 1). However, their endocranial morphology is poorly understood, and only one genus (Brindabellaspis) has been described thoroughly (2).. Here we present the 3D reconstruction of a subcomplete skull of Romundina stellina Ørvig, 3, from the Lochkovian of Prince of Wales Island, Canadian Arctic Archipelago. The specimen was imaged in 3D with propagation phase contrast microtomography (4) on the ID19 beamline of the ESRF, using a 7.45 µm isotropic voxel size.. Most features are properly ...
Since 2014 I have been on a Nutritional Balancing program that was designed for me specifically based on my tissue mineral levels from a simple-to-collect hair sample.. Despite being into health all of my adult life starting in my mid-teens and thinking that I was in the best health I could possibly be in my experience with Nutritional Balancing and Hair Tissue Mineral Testing has proved otherwise. I began for instance to take vitamins and minerals in my mid-teens about the same time I began to exercise regularly. Despite 20+ years of taking these expensive supplements to my diet and eating an organic diet of healthy food I was incredibly deficient as seen on my hair test. I will show you the evidence of this later in this article.. After dramatic health changes took place from being on this program I became a Nutritional Balancing Practitioner in 2016 so I can help others to change their health dramatically as well. The insights are just far too profound. I realize now it should be the bare ...
...LEMONT Ill. An international team of scientists using a new X-ray...This result showcases a new method to advance biological research and ...Scientists at Northwestern University and the Karlsruher Institut fr T...The results titled X-ray phase-contrast in vivo microtomography probe...,New,X-ray,method,shows,how,frog,embryos,could,help,thwart,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
We present an application of 3D X-ray computed microtomography for studying the influence of numerical cementation on flow in a cement-lined rough-walled fracture. The imaged fracture geometry serves...
This overview first summarizes the last decade of continuous developments and improvements in pre‐clinical imaging methods that are now essential tools for in vivo evaluation of cardiac morphology and function in living mice, involving nuclear emission of labeled molecules (micro‐PET and micro‐SPECT) and electromagnetic wave interactions with biological tissues (micro‐CT and micro‐MRI)
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Micro-focus Real-time Imaging Non-destructive Testing System Micro-focus Real-time Imaging Non-destructive Testing System Micro-focus real-time imaging non-destructive testing system is applied in the fields of non-destructive testing (NDT) and non-destructive evaluation (NDE). It is an advanced NDT....... ...
Mineral analysis, a hairy tool for preventive health. When Gold Medalist and three-time National Dressage Competitor Shannon Peters...
Gadi Pelled is the author of these articles in the Journal of Visualized Experiments: Bilgisayarlı Tomografi ve Osteogenezi-anjiyogenez bağlamalar Optik Görüntüleme Kranial Kemik Otogreftlerin ve allogreft Entegrasyon değerlendirmek için, Semiautomated boyuna Microcomputed tomografi tabanlı nicel yapısal analizi bir çıplak sıçan vertebra kırığı Osteoporoz ile ilgili Model
Zulma Gazit is the author of these articles in the Journal of Visualized Experiments: Bilgisayarlı Tomografi ve Osteogenezi-anjiyogenez bağlamalar Optik Görüntüleme Kranial Kemik Otogreftlerin ve allogreft Entegrasyon değerlendirmek için, Semiautomated boyuna Microcomputed tomografi tabanlı nicel yapısal analizi bir çıplak sıçan vertebra kırığı Osteoporoz ile ilgili Model
TY - CONF. T1 - Evaluating plant growth by electrical impedance tomography analysis. AU - Kobata, Kenji. AU - Honda, Satoshi. PY - 2013/1/1. Y1 - 2013/1/1. N2 - This paper shows how to evaluate plant growth by using electrical impedance tomography. Generally electrical impedance tomography (EIT) is used for human body and materials. By using the advantage that plants can be applied electricity inside, we can expect that more information is acquired. First, the problem is solved with a simple model analytically. Secondly, the problem with more precise model is solved numerically. In the previous work we showed how the electrical potential is distributed enough for using EIT.[7] This paper shows that how the inverse problem is solved and the advantage works.. AB - This paper shows how to evaluate plant growth by using electrical impedance tomography. Generally electrical impedance tomography (EIT) is used for human body and materials. By using the advantage that plants can be applied electricity ...
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Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by synovial macrophage activation. TA injections might influence macrophage activation and subsequently reduce osteophytosis. Although widely applied in clinical care, the mechanism through which TA exerts this effect remains unknown. In this animal study, we investigated the in vivo effects of TA injections on macrophage activation, osteophyte development and joint degeneration. Furthermore, in vitro macrophage differentiation experiments were conducted to further explain working mechanisms of TA effects found in vivo. Osteoarthritis was induced in rat knees using papain injections and a running protocol. Untreated and TA-treated animals were longitudinally monitored for 12 weeks with in vivo micro-computed tomography (μCT) to measure subchondral bone changes. Synovial macrophage activation was
Claw horn disruption lesions (CHDL; sole hemorrhage, sole ulcer, and white line disease) cause a large proportion of lameness in dairy cattle, yet their etiopathogenesis remains poorly understood. Untreated CHDL may be associated with damage to the internal anatomy of the foot, including to the caudal aspect of the distal phalanx upon which bone developments have been reported with age and with sole ulcers at slaughter. The primary aim of this study was to assess whether bone development was associated with poor locomotion and occurrence of CHDL during a cows life. A retrospective cohort study imaged 282 hind claws from 72 Holstein-Friesian dairy cows culled from a research herd using X-ray micro-computed tomography (μ-CT; resolution: 0.11 mm). Four measures of bone development were taken from the caudal aspect of each distal phalanx, in caudal, ventral, and dorsal directions, and combined within each claw. Cow-level variables were constructed to quantify the average bone development on all ...
Abstract: To evaluate the effect of methotrexate on collagen-induced arthritis, micro-computed tomography (micro-CT) and histopathological analyses were used in male Wistar rats. Rats were divided randomly into three groups. Group 1 was treated with 0.9% saline, and groups 2 and 3 were boosted with type Ⅱ collagen. From day 21 to 42, groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg methotrexate. All rats were sacrificed at day 42 after the first collagen treatment. Micro-CT analyses showed bony parameters, such as bone volume and trabecular number, were decreased in group 2 compared to group 1, and these parameters were recovered in group 3. Histopathological examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction, showing cartilage and bone erosion, enlarged cavities with inflammatory cell infiltration and activation of synovial fibroblasts. By contrast, these changes were ...
TY - JOUR. T1 - Quantitative analysis of vascular response after mandibular fracture repair using microcomputed tomography with vessel perfusion. AU - Donneys, Alexis. AU - Tchanque-Fossuo, Catherine N.. AU - Farberg, Aaron S.. AU - Jing, Xi Lin. AU - Deshpande, Sagar S.. AU - Goldstein, Steven A.. AU - Buchman, Steven R.. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Background: Poor healing after mandibular fracture repair can be a devastating morbidity with significant clinical consequences. Elucidating the vascular response after mandibular fracture may help determine potential areas for therapeutic interventions for nonunions. The authors performed microcomputed tomographic imaging after vessel perfusion to ascertain objective measures of vascular networks. They hypothesized that despite the haversian-based, highly cortical structure of the mandible, the vascular response after fracture healing will return to nearly normal levels soon after bony union, mirroring the results of endochondral, highly ...
DOI: 10.11607/jomi.4179 Purpose: Since bacterial leakage along the implant-abutment interface may be responsible for peri-implant infections, a realistic estimation of the interface gap width during function is important for risk assessment. The purpose of this study was to compare two methods for investigating microgap formation in a loaded dental implant, namely, microcomputed tomography (micro-CT) and three-dimensional (3D) nonlinear finite element analysis (FEA); additionally, stresses to be expected during loading were also evaluated by FEA. Materials and Methods: An implant-abutment complex was inspected for microgaps between the abutment and implant in a micro-CT scanner under an oblique load of 200 N. A numerical model of the situation was constructed; boundary conditions and external load were defined according to the experiment. The model was refined stepwise until its load-displacement behavior corresponded sufficiently to data from previous load experiments. FEA of the final, ...
The Sanagasta eggs (approx. 4850 cm3) are more than 1.5 times larger than those of other titanosaurs [1,5], paralleling the size difference between megapode eggs (e.g. Alectura lathami and Leipoa ocellata) and other galliformes of comparable body size [9]. Such larger eggs allow storage of more nutrients for prolonged incubation and hatching of hyperprecocial chicks [10,11]. Despite the difference in egg size, several morphological features of Z1 are strikingly reminiscent of the Auca Mahuevo titanosaur eggshells [12], including their Y-shaped pore canals (figure 3d). Typically, these eggshells are thinner than 1-1.2 mm at the time embryos hatch because their inner surface thins during embryogenesis [12-19] and the outer surface is eroded as a direct consequence of their incubation in burial conditions with ambient heat and moisture [1,5,12,20] in contrast with the classic avian contact incubation. In addition, calcium absorption from the inner surface of the eggshell is typically 4-8% during ...
The aim of this study was to observe the time-lapse changes in the rat periodontal ligament (PDL) during function and tooth movement. Under Nembutal anaesthesia, time-lapse changes in the thickness of the PDL of the first molars were investigated in five 12-week-old adolescent rats with microcomputed tomography. Three-dimensional (3D) images were reconstructed from the data. Histological observation was also performed, using undecalcified frozen sections of the maxillary first molar area.. The PDL appeared as a radiolucent furrow on the 3D images. A slight change in the thickness of the PDL was observed 1 hour after initiation of orthodontic force loading, which became significant after 6 hours, with the appearance of pressure-tension zones during the tooth movement. These changes were more significant 3 days after orthodontic loading.. Histological observation of the lingual cervical PDL (pressure zone) in nine 12- to 13-week-old rats demonstrated that the periodontal space had become narrow ...
Introduction Albert von Haller described Haller cells (HC) as anterior ethmoidal cells along orbital floor and above maxillary sinus ostium. Location of HC could predispose maxillary sinusitis (MS) Purpose of the Study Determine prevalence of HC and relationship of size-based HC with MS and orbital floor dehiscence (OD) in CBCT. Materials and Methods Fifty 9
Harris S, Bowles WR, Fok A, McClanahan SB. Anatomic investigation of the roots of mandibular first molars using micro-computed tomography. J Endod 2012;38:e52. Abstr.. Harris SP, Bowles WR, Fok A, McClanahan SB. An anatomical investigation of the mandibular first molar using micro-computed tomography. J Endod 2013; 39:1374-1378.. Barsness S, Bowles WR, Fok A, McClanahan SB, Harris SP. An anatomical investigation of the mandibular second molar using micro-computed tomography. Surgical & Radiologic Anatomy 2014; online publication August.. Wiswall A, Bowles W, Lunos S, McClanahan S, Harris S. Palatal anesthesia: comparison of four techniques for decreasing injection discomfort. Northwest Dent 2014;93:25-9. ...
We have two new papers out in PLoS ONE today describing some new species and highlighting the potential of micro-CT for ant taxonomy.. The first paper, headed by Eli and co-authored by Georg, revises one crazy spinescent Pheidole group from New Guinea, and notes interesting findings on the musculature under the spines. We named these species Pheidole drogon and Pheidole viserion after the dragons from George R.R. Martins A Song of Ice and Fire series.. The second paper, led by Georg, revises the Pheidole knowlesi group from Fiji including complete micro-CT galleries of all castes of six species from the group. This knowlesi group is not as morphologically spectacular as cervicornis, but is of great interest to us as it pertains to our work on the taxon cycle hypothesis.. We hope these show a glimpse of what cool things can be done with micro-CT for organismal biology, biodiversity studies, and taxonomy ...
The present studies investigated the cellular mechanisms for the detrimental effects of high dose whole body γ-irradiation on bone. In addition, radioadaptation and bone marrow transplantation were assessed as interventions to mitigate the skeletal complications of irradiation. Increased trabecular thickness and separation and reduced cancellous bone volume fraction, connectivity density, and trabecular number were detected in proximal tibia and lumbar vertebra 14 days following γ-irradiation with 6 Gy. To establish the cellular mechanism for the architectural changes, vertebrae were analyzed by histomorphometry 1, 3, and 14 days following irradiation. Marrow cell density decreased within 1 day (67% reduction, p , 0.0001), reached a minimum value after 3 days (86% reduction, p , 0.0001), and partially rebounded by 14 days (30% reduction, p = 0.0025) following irradiation. In contrast, osteoblast-lined bone perimeter was increased by 290% (1 day, p = 0.04), 1230% (3 days, p , 0.0001), and 530% ...
In this work, we found that bone mineral formation proceeded very rapidly in mice by 1 day of age, where the degree of mineralization, the tissue mineral density, and the mineral crystallinity reached 36%, 51%, and 87% of the adult values, respectively. However, even though significant mineralization had occurred, the elastic modulus of 1-day-old bone was only 14% of its adult value, indicating that the intrinsic stiffening of the bone lags considerably behind the initial mineral formation.. Introduction: To meet the mechanical challenges during early development, the skeleton requires the rapid accretion of bone quality and bone quantity. Here, we describe early bone development in the mouse skeleton and test the hypothesis that specific compositional properties determine the stiffness of the tissue.. Materials and Methods: Tibias of female BALB mice were harvested at eight time-points (n = 4 each) distributed between 1 and 40 days of age and subjected to morphometric (μCT), chemical (Fourier ...
1. Evaluation of all characters has to be carried out by at least two members of the staff who have to agree on the characters observed.. 2. Evaluation of all characters should be performed with each culture once a year.. 3. Evaluation should start with the observation of growth. Evaluation of all other characters of one cell line has to be finished within one month after entering the code number for growth into the computer. 4. For the evaluation of growth the increase in callus volume is observed over two growth cycles.. The following code numbers are used to describe growth: no growth = code no. 0; 30 - 50 % increase of cell material (callus volume) = code no. 1; 50 - 100 % increase of cell material (callus volume) = code no. 2, 100 % increase of cell material (callus volume) or more = code no. 3. 5. Consistency of the callus should be judged shortly after or ideally during regular transfer. The following code numbers are used to describe the consistency of callus: very soft = code no. -2; ...
Trends in micro- and nanoComputed Tomography (CT) from January 2008 through July 2010 are the subject of this brief report which takes up where a previous report in Developments in X-ray Tomography VI (2008) concluded. First, the number of systems operating world-wide is estimated. The main focus is on what searches of three citation indices (Web of Science, Compendex and PubMed) reveal about the field of micro- and nanoCT. Given research-fielddependent and disparate terminology used by investigators, searches were on "microtomography", "microCT" and "synchrotron tomography ...
All skulls and bone vary in size and shape. You will receive a high quality specimen of the selected item but not the exact one pictured. All skulls, bones and other animal parts are guaranteed to be top quality; sourced from ethical vendors around the world. Cheek tooth may come from horse, elk, bison, etc.
Sheeba conducts Hair Tissue Mineral analysis test which measures the mineral contents of ones hair taken from the scalp and sent for analysis.
Do newer instruments for preparing root canals induce small dentinal defects that can lead to root fractures, or have improvements in nickel titanium alloys alleviated this potential problem? Since the evidence is unclear, a new study used microcomputed tomography to analyze dentinal defects in root canals prepared with various instruments. Read more. ...
Video created by Duke University, North Carolina State University, The University of North Carolina at Chapel Hill for the course Nanotechnology: A Makers Course. In this module, we will see demonstrations of micro-computed tomography, X-ray ...
AMD dove further into the details of its core microarchitecture at the aptly-named HotChips conference, which is a yearly industry event that attracts the best and brightest of the processor world.
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Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
ATS now provides CT scanning services to its clients. Employing one of the most powerful NDT methods available, ATS is better prepared to provide critical analysis of our clients products and equipment.
Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography(審査報告)Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography(審査報告) ...
In this study using a newly developed CNT-based micro-CT with cardiac and respiratory gating, we have successfully quantified calcification in the aortic arch plaques of living mice. CNT-based sources are able to achieve a 10 ms or better temporal resolution, not directly achievable using conventional thermionic sources. As a result, we were able to gate cardiac and respiratory motion in a straightforward manner, allowing simplified animal handling without the need for intubation.. Heart contraction causes movement of the vascular wall and thereby motion blur in the acquired image.9 In addition, because the R-wave interval at 600 beats per minute is 100 ms, errors of pulse control ,5 to 10 ms could result in significant additional blur of structures. One of the key advantages of our CNT-based micro-CT system is the ability to control the x-ray pulses to at least a microsecond level. Although in vivo imaging of arch calcification has already been reported in B6-apoE KO mice using a conventional ...
This shows a micro-CT scan of a live, one-week-old male Colorado Potato Beetle. It was placed in a sort of suspended animation using carbon dioxide, was scanned using a micro-CT scan and then recovered fully.
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Childrens Hospital, Brigham and Womens Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute ...
Home , Equidae tridactyles (Hipparions sensu lato) , Northamerican archaic skulls, mandibles, and (...) , Skull, Mandible, and Cheek teeth photographs , Skull, Mandible, and Cheek teeth photographs ...
X-ray tomography or microtomography offers the oppurtunity to see inside objects. The object is digitized in its entire volume. It is possible to segment virtually regions of interest by their density differences.. Depending on the object size and the requested accuracy, we use medical CT scanners or microCT equipments.. With X-ray Tomography & microCT, it is possible to:. ...
Modern imaging methods make it possible to perform detailed, non-invasive studies on the internal structures of irreplaceable fossil specimens. Researchers led by Dr. Yu Liu of LMUs Department of Biology II now demonstrate the power of this approach by using computed microtomography (micro-CT) to investigate a specimen recovered from the famous fossil beds of Chengjiang in southwestern China. The results of the study, which appear in the online Open Access journal "Scientific Reports", demonstrate the ability of micro-CT to reveal anatomical details preserved inside fossil slabs.. The fossil Lagerstätte Chengjiang in China is a UNESCO World Heritage Site, which harbors a rich fossil assemblage dating from 520 million years ago. The rocks preserved here are among the oldest that document the so-called Cambrian explosion - the relatively abrupt appearance of a highly diverse, species-rich multicellular fauna in the fossil record. And many of the specimens discovered in these beds are extremely ...
Dr. G.B. John Mancini is a tenured Professor of Medicine at UBC and directs an imaging-based research program (Cardiovascular Imaging Research Core Laboratory, CIRCL) that includes facilities for quantitative coronary angiography, ultrasound analysis (coronaries, carotids and brachial artery for atherosclerosis and endothelial function assessments) and cardiac computed tomography analysis. Dr. Mancini remains in active practice as a staff physician in the Vancouver General Hospital Cardiology Outpatient Clinic and the Cardiac Computed Tomography Program as well as the St. Pauls Hospital Healthy Heart Prevention Program / Lipid Clinic.. Dr. Mancini received his MD degree from the University of Toronto, completed his residency at Toronto General Hospital and was a Cardiology and Research Fellow at the University of California at San Diego. After a year in the rank of Clinical Assistant Professor at U.C. San Diego, he joined the faculty of the University of Michigan, where he became Associate ...