Withaferin A is a steroidal lactone, derived from Acnistus arborescens, Withania somnifera (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family. It has been traditionally used in ayurvedic medicine. It is the first member of the withanolide class of ergostane type product to be discovered. This natural product has wide range of pharmacological activities including cardioprotective, anti-inflammatory, immuno-modulatory, anti-angiogenesis, anti-metastasis and anti-carcinogenic properties. Withanolides are a group of naturally occurring C28- steroidal lactones. They contain four cycloalkane ring structures, three cyclohexane rings and one cyclopentane ring. Withaferin A is highly reactive because of the ketone-containing unsaturated A ring, the epoxide in the B ring, and the unsaturated lactone ring. The double bond in ring A and the epoxide ring are mainly responsible for the cytotoxicity. The 22nd and 26th carbons of the ergostane skeleton in withaferin A and ...
Cervical cancer is caused by human papilloma virus (HPV) expressing E6 and E7 oncoproteins, which are known to inactivate tumor suppressor proteins p53 and pRb, respectively. Repression of HPV oncoproteins would therefore result in reactivation of tumor suppressor pathways and cause apoptosis in cancer cells. Withaferin A (WA), the active component of the medicinal plant Withania somnifera, has exhibited inhibitory effects against several different cancers. We examined the activity of WA on human cervical cancer cells in vitro and in vivo. WA potently inhibited proliferation of the cervical cancer cells, CaSki (IC(50) 0.45 ? 0.05 ?M). Mechanistically, WA was found to (i) downregulate expression of HPV E6 and E7 oncoproteins, (ii) induce accumulation of p53, (iii) increase levels of p21(cip1/waf1) and its interaction with proliferating cell nuclear antigen (PCNA), (iv) cause G(2)/M cell cycle arrest, associated with modulation of cyclin B1, p34(cdc2) and PCNA levels, (v) decrease the levels of ...
... and upregulation of tumor suppressor proteins in human cervical cancer cells ...
Title:Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review. VOLUME: 13 ISSUE: 4. Author(s):Hidayat Hussain*, Rene Csuk, Ivan R. Green, Najeeb Ur Rehman, Ghulam Abbas and Wahid Hussain. Affiliation:Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Salle), Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, UoN Chair of Omans Medicinal Plants and Marine Natural Products, University of Nizwa, P. O. Box 33, Birkat Al Mauz, Nizwa 616, Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa-616, Department of Botany, GPGC Parachinar Kurram Agency. Keywords:Anticancer, drug discovery, ergostane steroids, in vitro, natural products, withanolide.. Abstract:Withanolides are C-28 ergostane steroids known to ...
The main chemical constituents are alkaloids and steroidal lactones. These include tropine and cuscohygrine. The leaves contain the steroidal lactones, withanolides, notably withaferin A, which was the first to be isolated from the plant.[citation needed] Tropine is a derivative of tropane containing a hydroxyl group at third carbon. It is also called 3-tropanol. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class. Cuscohygrine is a pyrrolidine alkaloid found in coca.
Withanolide D Induces Apoptosis in Leukemia by Targeting the Activation of Neutral Sphingomyelinase-Ceramide Cascade Mediated by Synergistic Activation of C-Jun N-Terminal Kinase and P38 Mitogen-Activated Protein Kinase. ...
In the current investigation, we focused on Mortalin/mthsp70/GRP75, a member of the heat shock protein (Hsp) 70 family, which is enriched in human cancer cells [4, 9, 13]. It has been established that Mortalin has various subcellular localizations, interacts with multiple binding partners, and plays a role in carcinogenesis. Also, it is elevated in immortalized cell lines and tumor cells, and additional upregulation of Mortalin expression at later stages of carcinogenesis coincides with the acquisition of invasiveness [4]. Moreover, it has multiple functions contributing to continued proliferation of cancer cells, including mitochondrial-biogenesis, ATP production, anti-apoptosis, chaperoning, inactivation of tumor suppressor p53 and PI3K/AKT activities [14, 15]. Targeting Mortalin by siRNA, ribozymes and small molecules including MKT-077 and Withaferin A resulted in growth arrest/apoptosis of cancer cells [16-22].. Here, we confirmed that the level of Mortalin was elevated in breast cancer, ...
Current investigations are giving new insight about the roles of sphingolipids in cellular regulation of growth suppression, apoptosis and signal transduction. Among the sphingolipids, ceramide has emerged as an important second signal mediator, having multiple cellular and biochemical targets. In particular, ceramide act as a potent cell death inducer and a specific cell growth suppressor. Recently, it has been thought that generation of ceramide is a universal feature of apoptosis [6, 44]. Presently, a few drugs are available in combinatorial chemotherapy, which could generate ceramide. Therefore, to find pharmacological modulators that induce ceramide production in malignant cells by mounting a physiological response and induce senescence is on prime importance.. In the present study, we demonstrated rapid accumulation of endogenous ceramide in WithaD treated MOLT-4 cells. In fact, 61.55% cells were ceramide positive just in 30 mins. WithaD showed almost four fold increase in ceramide level ...
Golden Berries.Ingredients: Golden Berries Benefits of Golden / Gooseberry Berries: Golden Berries contain high amounts of withanolides and phenolics, components which make the fruit high in antioxidant activity. Due to these compounds, golde...
Wa - MedHelps Wa Center for Information, Symptoms, Resources, Treatments and Tools for Wa. Find Wa information, treatments for Wa and Wa symptoms.
Withania somnifera Common name: Ashwaghanda Family: Solanaceae Part used: Root & leaf Constituents: Steroidal lactones (withanolides, withaferins), sitoinosides, alkaloids, nutrients (iron) Actions: General tonic, rejuvenating, nervous system tonic, sedative, adaptogen, immuno-modulator, anti-tumor, anti-inflammatory, astringent, anti-anemic, aphrodisiac, oxytocic Medical uses: Is…
Background: Withania somnifera L. Dunal, (Ashwagandha) belongs to the family Solanaceae and is known as Indian ginseng in the traditional system of medicine. Objectives: In the present investigation, comparative analysis was carried out between two different ecotypes of W. somnifera related to total soluble protein and antioxidant enzyme activity [catalase (CAT), superoxide dismutase (SOD) and guaiacol peroxidase (GPX)] to find out the expression of isozyme in response to climatic variation. Materials and Methods: Viable and healthy seeds were germinated under the optimal condition to develop the in vitro and in vivo plants. The plant materials were taken for the analysis of total soluble protein and evaluated for antioxidant enzyme activity in both ecotypes. Results: Maximum protein (15.54 mg/gm fresh weight) was quantified from the in vitro grown plants of W1 ecotype. The CAT and SOD activity was found to be the maximum in W1 plants whereas, GPX activity was more in W2 plants. Specific activity
i] Bhattacharya S.K., Bhattacharya A., Sairam K., Ghosal S. "Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study." Phytomedicine 2000 Dec;7(6):463-9. (source). [ii] Kuboyama T., Tohda C., Komatsu K. "Neuritic regeneration and synaptic reconstruction induced by withanolide A." British Journal of Pharmacology 005 Apr;144(7):961-71. (source). [iii] Choudhary M.I., Yousuf S., Nawaz S.A., Ahmed S., Atta-ur-Rahman. "Cholinesterase inhibiting withanolides from Withania somnifera." Chemical and Pharmaceutical Bulletin (Tokyo) 2004 Nov;52(11):1358-61. (source). [iv] Kurapati K.R. , Atluri V.S., Samikkannu T., "Nair M. Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders" PLOS One journals.plos.org October 16, 2013 (source). [v] Cooley K., Szczurko O., Perri D., Mills E.J., Bernhardt B., Zhou Q., Seely D. "Naturopathic care for anxiety: a randomized controlled ...
Ashwagandha (Withania somnifera/W. ashwagandha) C Alam, N., et al. 2011. High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. BMC Complement. Altern. Med., 11, 65. URL: http://www.biomedcentral.com/1472-6882/11/65 (accessed 09.23.2011).. C Kumar, A., et al. 2011. Utility of a multidisciplinary approach for genome diagnostics of cultivated and wild germplasm resources of medicinal Withania somnifera, and the status of new species, W. ashwagandha, in the cultivated taxon URL: http://www.springerlink.com/content/g12001h123tk2876/ (accessed 09.06.2011).. C Sinha, S., et al. 2011. In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. J Ethnopharmacol. 2011 Mar 24;134 (2), 510-513. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/21182915 (accessed 09.23.2011).. C Dog, T. 2010. Smart Talk on supplements and botanicals: Ginseng and other adaptogenic herbs. ...
Withania somnifera, popularly known as ÂÂ AshwagandhaÂÂ , is one among the top rankingmedicinal plants of India and is highly valued f..
Withania somnifera (L.) Dunal, a highly reputed medicinal plant, synthesizes a large array of steroidal lactone triterpenoids called withanolides. Although its chemical profile and pharmacological activities have been studied extensively during the last two decades, limited attempts have been made to decipher the biosynthetic route and identification of key regulatory genes involved in withanolide biosynthesis. Cytochrome P450 reductase is the most imperative redox partner of multiple P450s involved in primary and secondary metabolite biosynthesis. We describe here the cloning and characterization of two paralogs of cytochrome P450 reductase from W. somnifera. The full length paralogs of WsCPR1 and WsCPR2 have open reading frames of 2058 and 2142 bp encoding 685 and 713 amino acid residues, respectively. Phylogenetic analysis demonstrated that grouping of dual CPRs was in accordance with class I and class II of eudicotyledon CPRs. The corresponding coding sequences were expressed in Escherichia coli as
... (Ashwagandha). Other Names: Ajagandha, Amangura, Amukkirag, Asgand, Asgandh, Asgandha, Ashvagandha, Ashwanga, Asoda, Asundha, Asvagandha, Aswagandha, Avarada, Ayurvedic Ginseng, Clustered Wintercherry, Ghoda Asoda, Hayahvaya, Kanaje Hindi, Kuthmithi, Physalis somnifera, Samm Al Ferakh, Samm Al Rerakh, Turangi-Ghanda, Vajigandha, Withania, Withania Coagulans,, Amukkrang Kilangu (in Tamil). Scientific name: Withania somnifera. Common names: Winter Cherry, Indian Ginseng, Poison Gooseberry. Ayurvedic names: Ashwagandha. Chinese names: Shui qie. Bangladesh names: Asvagandha. Arabic names: اشواغاندا ( Ashwagandha). Japanese Names: Seiyouotogirisou, Sekitomehoozuki Indo chōsen ninjin Indianjinsengu. Rainforest names:. Family: Solanaceae (nightshade). Approximate number of species known: 23. Common parts used: Root, fruit, leaf. Collection:. Annual/Perennial: Perennial. Height: 1-1.5 metres. Actions: Adaptogen, alterative, anti-anemic, anti-inflammatory, hypnotic, mild sedative, ...
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A number of studies in the recent past suggested that Withanolides, Withaferin-A and Withanone, have multi-modal anticancer activities, according to a release issued by IIT Delhi.
Germination requirements of ashwagandha are similar to peppers and tomatoes. Plant seeds approximately 1/4-1/2" deep in moist, well drained potting soil. Soil temperature must be kept at 75-90F for proper germination. Cool soil, particularly at night can inhibit or significantly delay germination. To keep soil temperature warm, start seeds indoors, in a greenhouse and/or use a seed starting heat mat. Keep soil moderately moist, though not overly, dripping wet. Water soil when the soil surface just begins to dry. Allow proper air circulation for containers. Germination usually takes a few weeks.. ...
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Shoden® is a registered trademark of Arjuna Natural Pvt. Ltd. India, and is part of an Exclusive Portfolio of Proprietary Ingredients from NutriScience Innovations LLC.. Description: Shoden® is a clinically-tested, purified extract from the leaves and roots of the Ashwagandha plant. With an industry leading 35% Withanolide Glycosides (measured by HPLC), Shoden® offers high bioavailability and guaranteed activity even at low doses. This multi-patented, advanced Ashwagandha extract is available in two forms for more formulation options: Shoden® BDS (Beadlet Delivery System) is a sustained release beadlet and Shoden® Powder is ideal for use in a variety of delivery systems.. ...
Ashwagandha is highly revered herb originating from India, and is sometimes referred to as Indian ginseng because of its panacea like effects in the body. We carry a few different extracts, and this one is a potent 60:1 extract. This would be excellent to pair with our 20% or 50% standardized ashwagandha extract. Ashwagandha is an amazing herb with an incredible range of benefits. It has pronounced mental, emotional, and physical based benefits, something many herbs cant claim.. There are studies proving mood boosting/balancing, anxiety/stress/depression reduction, improved sleep, anti-inflammatory/pain relief, reduction in LDL cholesterol and triglycerides, enhanced fat loss/lean mass/strength gain when lifting weights, thyroid and adrenal gland balance, neuron/dendrite/axon protection and regeneration, improvement of neuro-degenerative disorders, cardiovascular disease, sperm health, libido increasing, anti-acid, cortisol reducing, OCD, blood glucose reducing, insulin sensitizing, asthma ...
We tested three HSP90 inhibitors: Tanespimycin (already present in the cMap, used as control), the second-generation HSP90 inhibitors NVP-AUY922 (29) and NMS-E973 (30). Tanespimycin is close to all four HSP90 inhibitors present in the database, as well as, to the protein synthesis inhibitor Puromycin, and to the proteasome inhibitors Withaferin A and Parthenolide; a similar list was also obtained for NVP-AUY922 and NMS-E973. Fig. 3A shows the position of the three compounds in the DN. The closest community to the three tested compounds is n. 28, composed by the HSP90 inhibitors present in cMap, as well as the antiestrogen drug Fulvestrant, known to bind the estrogen receptor, dissociate HSP90, and trigger its intracellular degradation. The second closest community common to all the three compounds (n. 40) is enriched for proteasome inhibitors, ubiquitin proteasome system modulators (Celastrol, MG-132, MG-262, Thapsigargin, Disulfiram, Mometasone), and protein synthesis inhibitors (Puromycin and ...
Is anyone taking ashwagandha? If so, what has been your experience with it? Has it had a noticeable effect on any MS symptoms? Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced ...
It really is reported that the primary substance called Withania Somnifera , within this capsule is called the very best herb for rejuvenating your body and is
Bioactive withanolides in ashwagandha suppress the pathways causing several inflammation-based illnesses, including tumors, arthritis, asthma and hype
Bioactive withanolides in ashwagandha suppress the pathways causing several inflammation-based illnesses, including tumors, arthritis, asthma and hype
WFA also alters the organization of microtubules and microfilaments.BJ-5ta cell were treated with DMSO (A and C) and 2 μM WFA (B and D) for 3 hrs and stained w
Mfumo wa mmengenyo wa chakula (pia: mwanya wa chakula[1]) ni jumla ya viungo mwilini mwa binadamu na mamalia wengine vinavyofanya kazi ya kuingiza chakula mwilini, kukisagasaga, kukisafirisha ndani ya mwili, kukimengenya, kuondoa lishe ya mwili ndani yake, na kutoa mabaki nje ya mwili. Kwa hiyo mfumo wa mmengenyo wa chakula ni njia yote kuanzia mdomo hadi mkundu. Magonjwa yake huchunguzwa na elimu ya gastro-enterolojia. Kwa lugha nyingine unahusika na umengenyaji wa chakula mpaka kuwa katika hali inayoweza kusharabiwa na mwili. Ili chakula kiweze kutumika mwilini, ni lazima kivunjwevunjwe kiwe katika hali rahisi ya kuweza kusharabiwa. Kazi hiyo hufanywa na mfumo wa mmengenyo wa chakula. Mfumo wa mmengenyo wa chakula wa mwanadamu hufanana na ule wa sungura, panya au pimbi. Sehemu kuu zinazohusika katika umengenyaji huo ni kinywa, umio, mfuko wa tumbo, ini, mfuko wa nyongo, utumbo mwembamba, kongosho, utumbo mpana na puru. Chakula kinaposafiri katika njia yake hufanyiwa mabadiliko ya kiumbo ...
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Looking for online definition of Withania somnifera in the Medical Dictionary? Withania somnifera explanation free. What is Withania somnifera? Meaning of Withania somnifera medical term. What does Withania somnifera mean?
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Withania somnifera, also known as ashwagandha, is a herb that grows in India and North America. It has been used for thousands of years in Ayurvedic medicine in India to treat various ailments....
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The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of /sup 35/S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg/sup 2 +/ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue. ...
Ashwagandha may also interact with 5-hydroxytryptophan (5-HTP), anti-androgens, anticancer herbs and supplements, anti-inflammatory herbs and supplements, antioxidants, arginine or L-arginine, blood thinners, cholesterol-lowering herbs and supplements, fertility herbs and supplements, herbs and supplements that may affect heart rate, herbs and supplements that may affect the immune system, herbs and supplements that may affect muscle contractions, herbs and supplements that may affect the nervous system (including anticholinergic agents), herbs and supplements that may improve sex drive, herbs and supplements that may promote urination, herbs and supplements that may protect against radiation side effects, herbs and supplements that may treat heart disorders, herbs and supplements that may treat kidney disorders, herbs and supplements that may treat lung disorders, herbs and supplements that may treat Parkinsons disease, herbs and supplements that may treat stomach disorders, hormonal herbs and ...
Ashwagandha may also interact with 5-hydroxytryptophan (5-HTP), anti-androgens, anticancer herbs and supplements, anti-inflammatory herbs and supplements, antioxidants, arginine or L-arginine, blood thinners, cholesterol-lowering herbs and supplements, fertility herbs and supplements, herbs and supplements that may affect heart rate, herbs and supplements that may affect the immune system, herbs and supplements that may affect muscle contractions, herbs and supplements that may affect the nervous system (including anticholinergic agents), herbs and supplements that may improve sex drive, herbs and supplements that may promote urination, herbs and supplements that may protect against radiation side effects, herbs and supplements that may treat heart disorders, herbs and supplements that may treat kidney disorders, herbs and supplements that may treat lung disorders, herbs and supplements that may treat Parkinsons disease, herbs and supplements that may treat stomach disorders, hormonal herbs and ...
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Ashwagandha root has been used in India for at least between 3,000-5,000 years, to enhance libido and sexual vitality, improve fertility and overall reproductive health, and to reduce stress.
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