Waldenstrom Macroglobulinemia - MedHelps Waldenstrom Macroglobulinemia Center for Information, Symptoms, Resources, Treatments and Tools for Waldenstrom Macroglobulinemia. Find Waldenstrom Macroglobulinemia information, treatments for Waldenstrom Macroglobulinemia and Waldenstrom Macroglobulinemia symptoms.
Waldenstroms Macroglobulinemia Symptom: A few patients dont have side effects. For the individuals who have side effects, the most well-known ones are shortcoming, serious weakness, seeping from the nose or gums, weight reduction, and wounds or other skin sores. Seriously large amounts of IgM can prompt hyperviscosity disorder, in which the blood turns out to be unusually thick. Waldenstroms Macroglobulinemia Symptoms of this disorder incorporate visual issues (e.g., obscuring or loss of vision) and neurological issues (e.g., migraine, discombobulation, vertigo). Amid a physical exam, a specialist might likewise discover swelling of the lymph hubs, spleen, and/or liver.. Waldenstroms Macroglobulinemia Causes:. Waldenstroms macroglobulinemia is a consequence of a condition called lymphoplasmacytic lymphoma. The reason for the overproduction of the IgM counter acting agent is obscure, yet specialists trust it is made by lymphoma cells. Overproduction of Waldenstroms Macroglobulinemia Causes ...
TY - JOUR. T1 - Waldenstrom macroglobulinemia presenting as a bilateral subdural chronic hematoma. AU - Franzini, Andrea. AU - Gribaudi, Giulia. AU - Pirola, Elena. AU - Pluderi, Mauro. AU - Goldaniga, Maria Cecilia. AU - Marfia, Giovanni. AU - Rampini, Paolo Maria. PY - 2017/6/1. Y1 - 2017/6/1. KW - Bing Neel Syndrome. KW - Subdural chronic hematoma. KW - Waldenstrom macroglobulinemia. UR - http://www.scopus.com/inward/record.url?scp=85014106217&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85014106217&partnerID=8YFLogxK. U2 - 10.1016/j.jocn.2017.02.032. DO - 10.1016/j.jocn.2017.02.032. M3 - Article. AN - SCOPUS:85014106217. VL - 40. SP - 89. EP - 91. JO - Journal of Clinical Neuroscience. JF - Journal of Clinical Neuroscience. SN - 0967-5868. ER - ...
Certain risk factors may increase your chance of developing Waldenstrom macroglobulinemia. This guide will help you learn about possible causes of Waldenstrom macroglobulinemia.
Cases reported • Waldenstrom Macroglobulinemia; Lymphoma, Lymphoplasmacytoid; Macroglobulinemia. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Castillo, JJ, Ghobrial, IM, Treon, SP. Biology, prognosis, and therapy of Waldenström Macroglobulinemia. Cancer Treat Res. vol. 165. 2015. pp. 177-195. (Excellent review of recent progress in Waldenström Macroglobulinemia). Castillo, JJ, Olszewski, AJ, Kanan, S. Overall survival and competing risks of death in patients with Waldenström macroglobulinaemia: an analysis of the Surveillance, Epidemiology and End Results database. Br J Haematol. vol. 169. 2015. pp. 81-89. (Largest population-based study in Waldenström Macroglobulinemia.). Dimopoulos, MA, Anagnostopoulos, A, Kyrtsonis, MC. Primary treatment of Waldenström macroglobulinemia with dexamethasone, rituximab, and cyclophosphamide. J Clin Oncol. vol. 25. 2007. pp. 3344-3349. (Prospective study on cyclophosphamide, dexamethasone and rituximab in Waldenström Macroglobulinemia.). Dhodapkar, MV, Hoering, A, Gertz, MA. Long-term survival in Waldenström macroglobulinemia: 10-year follow-up of Southwest Oncology Group-directed ...
Waldenstroms macroglobulinemia is a rare type of cancer. Learn about waldenstroms macroglobulinemia prognosis, diagnosis, symptoms and treatment.
The following disease types are eligible: transformed lymphomas: diffuse large B cell lymphoma, mantle cell lymphoma, follicular lymphoma grade III; precursor B lymphoblastic leukemia/lymphoma; mediastinal (thymic) large B-cell lymphoma; Burkitt lymphoma/leukemia; precursor T-lymphoblastic leukemia/lymphoma; primary cutaneous anaplastic large cell lymphoma; anaplastic large cell lymphoma - primary systemic type; small lymphocytic lymphoma/chronic lymphocytic leukemia; follicular lymphoma, grades 1, 2; extranodal marginal zone B-cell lymphoma of MALT type; nodal marginal zone B-cell lymphoma; splenic marginal zone B-cell lymphoma; peripheral T cell lymphoma, unspecified; anaplastic large cell lymphoma (T and null cell type); lymphoplasmacytic lymphoma (Waldenstrom Macroglobulinemia); CNS lymphoma; post transplant lymphoproliferative disorders; mycosis fungoides/Sezary syndrome; primary effusion lymphoma; blastic NK-cell lymphoma; adult T-cell leukemia/lymphoma; extranodal NK/T-cell lymphoma, ...
These NCCN Guidelines Insights highlight the important updates/changes specific to the management of Waldenströms Macroglobulinemia/Lymphoplasmacytic Lymphoma. These include the addition of regimens containing novel agents as primary and salvage therapy options, inclusion of the updated summary of response categories and criteria from the sixth international workshop on Waldenströms Macroglobulinemia, and a section on management of peripheral neuropathy in the accompanying discussion.. ...
Waldenstrom macroglobulinemia is a rare cancer and is characterized by high level of immunoglobulin M (IgM) in the serum, which leads to increased serum viscosity, and presence of a lymphoplasmacytic infiltrate in the bone marrow. Waldenstrom macroglobulinemia starts in B cells or B lymphocytes and leads to excess amount of IgM. Treatment options for Waldenstrom macroglobulinemia vary according to symptoms. In the last few years, medical science has made much progress and a number of new treatments for this type of cancer have been introduced. However, very few studies have been done to compare the treatment options and thus, discover the best available option. Hence, there is no single treatment available that works for all patients.
PURPOSE: Allogeneic stem-cell transplantation (alloSCT) is a curative therapeutic option for patients with low-grade lymphoid malignancies. Information regarding alloSCT in Waldenstrom macroglobulinemia (WM) is limited. This study presents the long-term outcome of a large series of patients with WM treated with alloSCT. PATIENTS AND METHODS: A total of 86 patients received allograft by using either myeloablative (MAC; n = 37) or reduced-intensity conditioning (RIC; n = 49) regimens and were retrospectively studied. The median age was 49 years (range, 23 to 64 years); 47 patients had received three or more previous lines of therapy, and eight patients had experienced failure on a prior autologous stem-cell transplantation. A total of 59 patients (68.6%) had chemotherapy-sensitive disease at the time of alloSCT. Median follow-up of the surviving patients was 50 months (7 to 142 months). RESULTS: Nonrelapse mortality (NRM) at 3 years was 33% for MAC and 23% for RIC. The overall response rate was ...
Waldenström macroglobulinemia (WM) is a cancer of the B lymphocytes (a type of white blood cell). WM is associated with the overproduction of proteins called IgM antibodies.
Waldenstrom macroglobulinemia (WM) is a type of non-Hodgkin lymphoma (NHL) that produces large amounts of an abnormal protein (called a macroglobulin). Learn more here.
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Waldenstroms macroglobulinemia (WM) is a rare chronic B-cell lymphoproliferative disorder characterized by macroglobulin (immunoglobulin M; IgM) paraproteinemia. The clinical manifestations associated with WM can be related to those of direct organ tumor infiltration, hyperviscosity and tissue deposition of IgM. Treatment must be individualized according to the nature of the clinical manifestations. Plasmapheresis has a role in patients whose symptoms are caused by increased serum viscosity. Chlorambucil was first used with response rates varying between 31% and 72% and is now probably the most commonly used oral agent. Melphalan and cyclophosphamide may have similar clinical efficacy. The addition of corticosteroids does not seem to increase response rates and the use of combination chemotherapy in the first-line setting is not recommended. Fludarabine and cladribine are cross-resistant and induce a response in 30%-60% of patients who have had prior therapy with alkylating agents and as many ...
The purpose of this study is to obtain bone marrow and peripheral blood samples, along with clinical data from patients with Multiple Myeloma (MM), Waldenstroms Macroglobulinemia (WM), Smoldering MM, and other lymphoplasmacytic lymphomas (LPL) including but not limited to MGUS and IgG or IgA LPL. These samples will become part of a tissue bank and will be used in ongoing studies to find out more about the causes and biology of MM, WM and LPL; to identify what factors result in normal cells becoming cancer; to determine how to improve treatment options; to study how the immune system identifies abnormal cells; and to evaluate the immune function in these diseases. The investigators will also study the tumor cells at the level of the participants genes to develop treatment strategies as well as to better understand how biologic differences affect patient outcomes ...
Waldenstroms macroglobulinemia (WM) is a rare subtype of B-cell lymphoma, making up 1 to 2 percent of all non-Hodgkin lymphoma (NHL) cases. WM is considered to be an indolent (slow growing) lymphoma and it is primarily found in the bone marrow although lymph nodes can also be affected WM is named after the scientist who first described it. The cancer cells make large amounts of a certain type of antibody (IgM), which is known as macroglobulin. A build-up of this protein can lead to symptoms such as excess bleeding, problems with vision, and the nervous system. WM causes the overproduction of monoclonal protein called immunoglobulin M referred to as IgM. This overproduction in IgM can result in the thickening of the blood known as hyper viscosity which causes the blood to thicken and impairs blood flow.. WM is an incurable lymphoma, but it can respond very well to treatment with many patients achieving long-term remission periods. Some patients will be offered the watch and wait approach if ...
What reasons Waldenstroms Macroglobulinemia like numerous different diseases are obscure despite the fact that it is trusted that a change in DNA could be a reason. Despite this absence of assurance on the Waldenstrom Macroglobulinemia Causes there are thought to be elements which improve the probability of building up the malady. The lions share of instances of waldenstroms macroglobulinemia happen in those beyond 50 years old and the normal time of event is 61. Occurrence of the ailment is twice as much in men than ladies. The condition is likewise acquired which implies that those with family who have Waldenstroms or a kind of lymphatic tumor are more prone to get the condition.. Symptoms A first conclusion of Waldenstroms is mind boggling in light of the fact that there is typically an unlucky deficiency of Waldenstroms Macroglobulinemia Symptoms right off the bat. Typically the first sign of Waldenstroms originates from routine examinations indicating atypical results. These ...
Waldenstroms macroglobulinemia (WM) is an uncommon low-grade lymphoma. Cognitive impairment due to central nervous system infiltration by lymphoplasmocytoid cells (Bing-Neel syndrome) has been rarely reported. We describe a 54-year-old man who was referred to a memory disorder clinic with a 9-month history of clinically obvious nonfluent aphasia and WM. He underwent extensive neuropsychological testing, clinical examination and structural and functional brain imaging. The diagnosis of the diffuse form of the Bing-Neel syndrome was supported by abnormal lymphoid cells found in the cerebrospinal fluid. Structural and functional brain imaging revealed impairment of brain areas due to white matter changes and subsequent functional deficits mimicking the neuropsychological syndrome encountered in progressive nonfluent aphasia. The diffuse form of Bing-Neel syndrome and neurological deficits are assumed to be the result of leptomeningeal infiltration by malignant cells and/or neoplastic vascular ...
This research study is studying Ulocuplumab combined with ibrutinib as a possible treatment for symptomatic Waldenstroms Macroglobulinemia (WM).
What Is Waldenstroms Macroglobulinemia Disease? Your immune system produces cells that protect your body against infection. One such cell is the B lymphocyte, which is also known as a B cell. B cells are made in the bone marrow. They migrate and mature in your lymph nodes and spleen. They can become plasma cells, which are … Continue reading. ...
Waldenstroms Macroglobulinemia is a rare disorder that causes the generation of irregular B-lymphocytes, white platelets. It has a portion of the same elements of both lymphomas and of numerou...
TY - JOUR. T1 - Small-intestinal involvement in Waldenstroms macroglobulinemia - Case report and review of the literature. AU - Brandt, Lawrence J.. AU - Davidoff, Allen. AU - Bernstein, Leslie H.. AU - Biempica, Luis. AU - Rindfleisch, Burton. AU - Goldstein, Mervyn L.. PY - 1981/2. Y1 - 1981/2. UR - http://www.scopus.com/inward/record.url?scp=0019391786&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019391786&partnerID=8YFLogxK. U2 - 10.1007/BF01312238. DO - 10.1007/BF01312238. M3 - Article. C2 - 6780283. AN - SCOPUS:0019391786. VL - 26. SP - 174. EP - 180. JO - Digestive Diseases and Sciences. JF - Digestive Diseases and Sciences. SN - 0163-2116. IS - 2. ER - ...
TY - JOUR. T1 - Defining lymphoplasmacytic lymphoma. T2 - Does MYD88L265P define a pathologically distinct entity among patients with an IgM paraprotein and bone marrow-based low-grade b-cell lymphomas with plasmacytic differentiation?. AU - Fang, Hong. AU - Kapoor, Prashant. AU - Gonsalves, Wilson. AU - Frederick, Lori A.. AU - Viswanatha, David. AU - Howard, Matthew T.. AU - He, Rong. AU - Morice, William G.. AU - McPhail, Ellen. AU - Greipp, Patricia T. AU - Ansell, Stephen Maxted. AU - Kyle, Robert A.. AU - Gertz, Morie. AU - Paludo, Jonas. AU - Abeykoon, Jithma. AU - King, Rebecca. PY - 2018/7/3. Y1 - 2018/7/3. N2 - Objectives Lymphoplasmacytic lymphoma (LPL) remains a poorly defined entity, even with the discovery of MYD88 L265P mutations and association with Waldenström macroglobulinemia (WM). Among bone marrow (BM)-based, low-grade B-cell lymphoma with plasmacytic differentiation (LGBLPD) and immunoglobulin M (IgM) paraproteins, we sought to determine whether MYD88 L265P defines a ...
Activating mutations in MYD88 and CXCR4 mutations are present in 95-97% and 40-45% of previously untreated patients with Waldenströms macroglobulinemia, respectively. MYD88 mutations trigger malignant cell growth through Brutons Tyrosine Kinase and Hematopoietic Cell Kinase, both targets of ibrutinib (Yang et al, Blood 2013; Blood 2016). CXCR4 mutations confer in vitro as well as clinical evidence of resistance in previously treated WM patients to ibrutinib (Cao et al, Leukemia 2014, Treon et al NEJM 2015). Ibrutinib produces overall and major [partial response (PR) or better] responses in 90% and 70-75% of previously treated WM patients (Treon et al, NEJM 2015; Dimopoulos et al, Lancet Oncol. 2017). The activity of ibrutinib in untreated, symptomatic WM patients is not known. We therefore investigated the activity and safety of ibrutinib in this patient population. Thirty patients were enrolled in this study. Key baseline characteristics were as follows: median age 67 (range 43-83 yrs); 23 ...
Waldenstroms Macroglobulinemia. indolent lymphoma occurs > 30years, usually > 60years characterised by proliferation of lymphoplasmatic and plasma cells monoclonal immunoglobulin M. Waldenstroms Macroglobulinemia - clinical presentation. asymptomatic symptomatic ...
Lymphoplasmacytic lymphoma cells have characteristics of both lymphocytes and plasma cells. Learn about lymphoplasmacytic lymphoma.
What is Waldenstrom's macroglobulinemia, who gets it, what are the symptoms, and how is it treated initially and when it relapses?
Waldenströms macroglobulinemia (WM) is an indolent and incurable B-cell neoplasm defined by the accumulation of lymphoplasmacytic cells in the bone marrow and characterized by the hypersecretion of monoclonal immunoglobulin M (IgM) protein.1 Representing 1-2% of hematologic cancers, WM is seen more frequently in white males, with a median age at diagnosis of 63 years.2,3. The bone marrow infiltrate consists of a heterogeneous population of post-germinal center (hypermutated), mature B cells, ranging from small B lymphocytes (CD19, CD20) to completely differentiated plasma cells (CD138), half of which may have visible cytoplasmic inclusions, known as Dutchers Bodies.2,3. The clinical presentation of WM patients varies. Approximately 30% of patients with WM demonstrate indolent disease (smoldering WM). In the remaining WM patients, the clinical features can include hyperviscosity (due to hypersecretion of IgM approximately 100-fold higher than normal range values), anemia, organomegaly ...
To the Editor: Purine analogues, including cladribine (2-chlorodeoxyadenosine), are increasingly used in the treatment of Waldenstroms macroglobulinemia and other hematologic cancers. (1) Cladribine can cause profound immunosuppression, lymphopenia, and increased susceptibility to opportunistic infections. (2) We report on a patient with Waldenstroms macroglobulinemia in whom an Epstein-Barr virus (EBV)-associated diffuse large-cell lymphoma developed after treatment with cladribine. A 69-year-old woman received the diagnosis of Waldenstroms macroglobulinemia with IgM kappa in 1991. Because of the progression of the disease, treatment with standard doses of cladribine was initiated in June 1994 and repeated in August 1994. The patient had a remarkable response, with alleviation of her symptoms and more than 90 percent reduction of the serum paraprotein level. Five months after the completion of treatment with cladribine, pain developed in the right hip, and a right acetabular lytic lesion was ...
Waldenströms macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. WM is characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the cells involved in the disease. WM is an indolent lymphoma (i.e., one that tends to grow and spread slowly) and a type of lymphoproliferative disease which shares clinical characteristics with the indolent non-Hodgkin lymphomas. WM is commonly classified as a form of plasma cell dyscrasia. Similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. IgM MGUS) and smoldering Waldenströms macroglobulinemia. The WM spectrum of dysplasias differs from other spectrums of plasma ...
Waldenstr?m macroglobulinemia (WM) is a significant and frequently fatal B-cell malignancy associated with an elevated monoclonal IgM protein in the serum. BLyS was found to increase the viability and proliferation BMS-582664 of malignant B cells from WM patients. Due to the role of BLyS in WM, strategies to inhibit BLyS may potentially have therapeutic efficacy in these patients. Introduction Waldenstr?m macroglobulinemia (WM) is an uncommon disorder characterized by the production of a monoclonal IgM protein, a lymphoplasmacytic infiltrate in the bone marrow, and associated symptoms such as anemia, lymphadenopathy, and hyperviscosity.1-4 Despite significant clinical improvements in the treatment of WM, it remains incurable and most patients succumb to disease progression. Thus, there is an increasing need for novel effective therapies. An important component in the development of new therapies is an understanding of the mechanism(s) that underlies resistance to apoptosis, resulting in extended ...
CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA Williams Hematology CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA THOMAS J. KIPPS Definition and History Lymphoplasmacytic Neoplasms B-Lymphocytic Neoplasms Essential Monoclonal Macroglobulinemia Etiology and Pathogenesis Etiology Pathogenesis Clinical Features The Hyperviscosity Syndrome Laboratory Findings Serum Immunoglobulin and Blood Viscosity Blood and Marrow Cells Disorders of Hemostasis Renal Abnormalities Differential Diagnosis Therapy, Course, and Prognosis…
Individualized treatment for Waldenström's macroglobulinemia (WM) has become a feasible strategy with improved understanding of the disease and expanded treatment options.
Export Date: 18 February 2017References: Treon, S.P., Waldenströms macroglobulinemia: an indolent B-cell lymphoma with distinct molecular and clinical features (2013) Hematol Oncol, 31, pp. 76-80;Dimopoulos, M.A., Kastritis, E., Owen, R.G., Treatment recommendations for patients with Waldenström macroglobulinemia (WM) and related disorders: IWWM-7 consensus (2014) Blood, 124, pp. 1404-1411; Buske, C., Leblond, V., How to manage Waldenströms macroglobulinemia (2013) Leukemia, 27, pp. 762-772; Buske, C., Sadullah, S., Kastritis, E., Treatment and outcome patterns in patients with relapsed Waldenströms macroglobulinemia: development of a large observational Pan-European data platform (2016), The 21st European Hematology Association Annual Congress; Copenhagen, Denmark; June 9-12,. Abstr E1275Castillo, J.J., Kanan, S., Meid, K., Manning, R., Hunter, Z.R., Treon, S.P., Rituximab intolerance in patients with Waldenström macroglobulinaemia (2016) Br J Haematol, 174, pp. 645-684; Treon, S.P., ...
Introduction. Waldenström macroglobulinemia is defined by the World Health Organization and the International Waldenströms Working Group as the presence of bone marrow lymphoplasmacytic lymphoma associated with a monoclonal IgM protein of any size. The bone marrow morphology shows both CD38 expressing plasma cells and CD20 expressing lymphoplasmacytic cells. A monoclonal protein is invariably visible on the serum protein electrophoresis. Immunofixation identifies an IgM heavy chain. One of the defining syndromes of Waldenström macroglobulinemia is the development of hyperviscosity due to the impact of pentameric IgM on the flow of serum. The most common signs of hyperviscosity are oronasal bleeding or blurred vision secondary to retinal hemorrhage.. IgM monoclonal serum proteins represent 18% of all monoclonal proteins seen. Since monoclonal gammopathy of undetermined significance (MGUS) is seen in 3% of adults over the age of 70, 1 adult in 200 will have an IgM monoclonal protein. However, ...
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Purpose: Everolimus inhibits mTOR, a component of PI3K/AKT prosurvival signaling triggered by MYD88 and CXCR4-activating mutations in Waldenstrom macroglobulinemia.. Experimental design: We evaluated everolimus in a prospective, multicenter study of 33 symptomatic, previously untreated Waldenstrom macroglobulinemia patients. Intended therapy consisted of everolimus (10 mg/day) until progression or unacceptable toxicity. Dose deescalation was permitted. The study was registered at www.clinicaltrials.gov (NCT00976248).. Results: At best response, median serum IgM levels declined from 4,440 to 1,360 mg/dL (P , 0.0001), median hemoglobin rose from 10.8 to 12 g/dL (P = 0.001), and median bone marrow disease burden declined from 75% to 52.5% in serially biopsied patients. The ORR and major response rates were 72.7% and 60.6%, respectively. Among genotyped patients, nonresponders associated with wild-type MYD88 and mutated CXCR4 status. Median time to response was 4 weeks. Discordance between serum IgM ...
TY - JOUR. T1 - Molecular pathogenesis of Waldenströms macroglobulinemia. AU - Braggio, Esteban D. AU - Philipsborn, Casey. AU - Novak, Anne J. AU - Hodge, Lucy. AU - Ansell, Stephen Maxted. AU - Fonseca, Rafael. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Waldenströms macroglobulinemia is an indolent, lymphoproliferative disease, characterized by a heterogeneous lymphoplasmacytic bone marrow infiltrate and high immunoglobulin M production. While technological advances over the past several decades have dramatically improved the possibilities of studying the molecular basis of Waldenströms macroglobulinemia, the pathogenesis of the disease remains fragmented. Undoubtedly, research has been successful in uncovering underlying aberrations and deregulated mechanisms in this disease, providing useful information for identifying biomarkers for disease diagnosis, risk stratification and therapeutic intervention, but there is still a long way to go before the pathogenesis of Waldenströms ...
Looking for online definition of macroglobulinaemia in the Medical Dictionary? macroglobulinaemia explanation free. What is macroglobulinaemia? Meaning of macroglobulinaemia medical term. What does macroglobulinaemia mean?
A marked increase in serum viscosity may be responsible for many of the disease manifestations of pathologic states associated with elevated serum macroglobulin levels. For this reason, rational therapy was directed at reduction of serum viscosity and macroglobulin level.. Schwab and Fahey (New Engl. J. Med. 263: 574, 1960) have reported the beneficial effect of plasmapheresis in two patients with Waldenströms macroglobulinemia. Current evaluation of the therapeutic usefulness of plasmapheresis is based on observations in ten patients with macroglobulinemia. Many disease manifestations including bleeding diathesis, visual disturbance and retinal hemorrhages, vertigo and other neurological symptoms, and cardiac limitations were reversed ...
Lymphoma Research Foundation Ask The Doctor Program Thursday, November 16 6:30-8:30 PM Courtyard Salt Lake City Downtown by Marriott 345 west 100 South Salt Lake City, UT 84101 Information: Lymphoma.org Contact: [email protected], 1-800-500-9976
TY - JOUR. T1 - Nodular lymphoma associated with macroglobulinaemia. AU - Moragas, A.. AU - Guardia, J.. AU - Martinez Vazquez, J. M.. PY - 1973/1/1. Y1 - 1973/1/1. N2 - A case is described of multiple adenopathy with hepatosplenomegaly, lymphocyte infiltration of the bone marrow, IgM paraprotein in the plasma and type Kappa Bence Jones proteinuria, with lymph gland histology corresponding to a nodular lymphoma. During the evolution there was a reduction of the tumor masses and of the protein anomalies, which were still present a year later. The demarcation line existing between true macroglobulinemia and immunoglobulin secreting lymphoma is discussed.. AB - A case is described of multiple adenopathy with hepatosplenomegaly, lymphocyte infiltration of the bone marrow, IgM paraprotein in the plasma and type Kappa Bence Jones proteinuria, with lymph gland histology corresponding to a nodular lymphoma. During the evolution there was a reduction of the tumor masses and of the protein anomalies, ...
Purpose To describe a series of 4 patients with Waldenström macroglobulinemia and serous macular detachment, and propose a mechanism for development of subretinal fluid based on optical coherence tomography (OCT) findings. Design Retrospective observational case series. Methods The records of patients with Waldenström macroglobulinemia and OCT documentation of serous macular detachment at Wills Eye Institute…
Hyperviscosity syndrome (HVS) refers to the clinical sequelae of increased blood viscosity. Increased serum viscosity usually results from increased circulating serum immunoglobulins and can be seen in such diseases as Waldenström macroglobulinemia and multiple myeloma.
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.. You usually have no Bence-Jones proteins in your urine. The presence of Bence-Jones proteins in urine can be a sign of multiple myeloma or another rare condition called Waldenstrom macroglobulinemia. About 50% to 80% of people with multiple myeloma have Bence-Jones proteins in their urine.. This protein can also be present if you have monoclonal gammopathy of undetermined significance, or MGUS. In this condition, your plasma cells make more of one kind of antibody than they should, but they dont form a tumor or make enough antibodies to do damage. MGUS doesnt generally need treatment. But if you have MGUS, you are at higher risk of developing multiple myeloma. You are also at higher risk for lymphoma, a cancer affecting white ...
Top 10 cancers for 1552856_at (Homo sapiens, Affymetrix Probeset): connective and soft tissue, fibrous histiocytoma tumor cells, malignant, multiple myeloma, secondary, Waldenstrom macroglobulinemia, refractory anemia with excess blasts, skin, malignant melanoma, NOS, unstated behavior, adrenal gland, aldosterone-producing adenoma, acute monoblastic/monocytic leukemia, nasopharynx, carcinoma, NOS, adrenal gland, unspecified, breast, carcinoma, NOS
The salt Chlorambucil is used for the treatment of HodgkinS Lymphoma, Non-HodgkinS Lymphoma, Chronic Lymphocytic Leukemia, WaldenstromS Macroglobulinemia and
Pharmacyclics, Inc, announced that the FDA has granted an additional Breakthrough Therapy Designation for the investigational oral agent ibrutinib as monotherapy for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma with deletion of the short arm of chromosome 17 (deletion 17p). Patients harboring a deletion within chromosome 17 generally have poor response to chemoimmunotherapy and have limited treatment options. The presence of deletion 17p is one of the worst prognostic factors in patients with CLL.. In February 2013, the FDA granted Breakthrough Therapy Designations for ibrutinib as a monotherapy for the treatment of patients with relapsed or refractory mantle cell lymphoma and as a monotherapy for the treatment of patients with Waldenstroms macroglobulinemia, both of which are also B-cell malignancies. Ibrutinib is jointly being developed by Pharmacyclics and Janssen for treatment of B-cell malignancies.. Clinical Studies. The new designation ...
Patients will present with symptoms either specific to AIHA-induced hemolysis or a potential secondary cause of AIHA. If the anemia is severe enough, the patient will present with symptoms of fatigue, weakness, dizziness, and dyspnea. It is rare to see symptoms of bleeding.. WAIHA constitutes the majority of cases (70%). It usually affects women (2:1) and often manifests around age 40. The most commonly associated secondary conditions of wAIHA are the lymphoproliferative disorders (lymphoma, leukemia, Waldenstroms macroglobulinemia, myeloma). Autoimmune disorders have also been implicated including lupus, Sjogrens syndrome and rheumatoid arthritis.. Since hematologic malignancies and lupus are the two most commonly associated secondary causes of AIHA (albeit rare), patients may present with symptoms specific to the condition such as weight loss, night sweats, fevers, abdominal fullness, or lymph node enlargement with lymphoma and the characteristics associated with lupus including facial rash, ...
Alcohol consumption - a risk factor for hemorrhagic and non-hemorrhagic stroke. Hemorrhagic disorder due to an Isoniazid-associated acquired factor XIII inhibitor in a patient with Waldenstroms macroglobulinemia
Multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma, and monoclonal gammopathy of undetermined significance (MGUS) are different types of plasma cell neoplasms. Find out about risk factors, symptoms, tests to diagnose, prognosis, stages, and treatment for these diseases.
An asymptomatic non-diabetic 69-year-old man with no medical history was referred for incidental bilateral retinal haemorrhages. Visual acuities were 20/20 in both eyes. Anterior segment examination was unremarkable. Funduscopy revealed normal optic discs and maculae and bilateral peripheral blot haemorrhages and microaneurysms (figure 1A,B). Wide-field fluorescein angiography showed peripheral retinal vessel wall staining with capillary non-perfusion and scattered microaneurysms (figure 1C,D). Blood … ...
Serum protein electrophoresis was performed in 63% of 1,069 consecutive patients with lymphoma. No monoclonal peaks of IgM specificity were found in sera from 345 patients with nodular lymphoma or Hodgkins disease. Of the remaining 333 patients with diffuse lymphoma, 1.5% had an IgG peak, suggesting a coincidental relationship of IgG peaks to lymphoma. IgM peaks occurred in 3.6% of patients with diffuse lymphoma, a prevalence about 60 times more frequent than that in normal subjects. Such peaks were more frequent in older patients, suggesting an increased incidence of lymphomas producing monoclonal macroglobulins with advancing age. There was a close correlation between lymphoma mass and the level of the IgM peak in individual patients. Results supported the value of identifying monoclonal components in all patients with lymphoma, particularly those with diffuse lymphocytic infiltration. ...
article{10c56b49-4204-476a-bc18-797a639917af, abstract = {Multiple myeloma (MM) is a disease of immunoglobulin producing plasma cells which reside mainly in the bone marrow. Family members of MM patients are at a risk of MM but whether other malignancies are in excess in family members is not established and is the aim of this study. MM patients (24,137) were identified from the Swedish Cancer Registry from years 1958-2012. Relative risks (RRs) were calculated for MM defined by any cancer diagnosed in first degree relatives and compared to individuals whose relatives had no cancer. MM was reliably associated with relatives colorectal, breast and prostate cancers, non-thyroid endocrine tumors, leukemia and cancer of unknown primary; additionally MM was associated with subsites of bone and connective tissue tumors and of non-Hodgkin lymphoma, including lymphoplasmacytic lymphoma/Waldenström macroglobulinema (RR 3.47). MM showed a strong association (RR 1.91) in colorectal cancer families, ...
The disease is classified as a subset of lymphoma and also has characteristics in common with chronic lymphocytic leukemia and multiple myeloma.. Multiple myeloma is characterized by excessive growth (neoplastic proliferation) of plasma cells. Plasma cells are produced in the marrow and eventually enter the blood stream. They are a key component of the immune system and secrete a substance known as M-protein, a type of antibody. Antibodies, also known as immunoglobulins, are produced by the body to combat invading microorganisms, toxins, or other foreign substances. Overproduction of plasma cells in affected individuals results in abnormally high levels of these proteins in the body. In addition, excessive plasma cells may eventually mass together to form a tumor, known as a plasmacytoma, in various sites of the body, especially the bone marrow.. Chronic lymphocytic leukemia is the most common type of leukemia in people over 50 years of age. It is characterized by fatigue, weight loss, repeated ...
Becki has a close family member who was diagnosed with an incurable lymphoplasmacytic lymphoma in 1989. She refers to them as a silent survivor. Not everyone is comfortable telling their cancer story because they are afraid of being treated differently or they may have survivors remorse. In 2015 Becki was approached by another person with cancer and asked to work on a documentary film about cancer, giving her an opportunity to be a public voice for many who cant be. She became involved with the Pineapple Classic and LLS because she believes in the organizations mission in funding research and improving quality of life for families and patients living with cancer. Without organizations like LLS her silent survivor would not be where she is today. top ...
Because the M-protein of patients with WM is almost always IgM, a broad differential should be considered for lucent bone lesions (the M-protein of multiple myeloma is usually IgG, followed by IgA and IgD, with IgM myeloma making up about 1% of cases). The same can be said for sclerotic bone lesions with or without peripheral neuropathy (the M-protein of POEMS is usually IgG and IgA, with IgM POEMS being very rare). However, this information is not always available when interpreting initial staging studies for patients with newly diagnosed plasma cell dyscrasia ...
Free, official info about 2015 ICD-9-CM diagnosis code 273.3. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
Multiple Myeloma + Altered Mental Status=Hyperviscosity Syndrome. Although the differential diagnosis of altered mental status is quite extensive, a patient with multiple myeloma and altered mental status should prompt consideration of one important, albeit not too common, condition.....hyperviscosity syndrome.. Some important pearls:. ...
Learn about the causes, symptoms, diagnosis & treatment of Perinatal Hematologic Disorders from the Professional Version of the Merck Manuals.
Hyperviscosity Syndrome Presenting as Exercise Induced Pulmonary Hypertension in a Heart Transplant Patient We report an unusual case of exertional dyspnea and exe..
The use of stem cell transplantion (SCT) therapy has also been explored in patients WM. Desikan et al177 reported their initial experience of high-dose chemotherapy and autologous stem cell transplant, which has more recently been updated by Munshi et al.178 Their studies involved eight previously treated WM patients between the ages of 45 and 69 years, who received either melphalan at 200mg/m2 (n = 7) or melphalan at 140mg/m2 along with total body irradiation. Stem cells were successfully collected in all eight patients, although a second collection procedure was required for two patients who had extensive previous nucleoside analogue exposure. There were no transplant related mortalities and toxicities were manageable. All eight patients responded, with 7 of 8 patients achieving a major response, and one patient achieving a complete response with durations of response raging from 5+ to 77+ months. Dreger et al179 investigated the use of the DEXA-BEAM (dexamethasone, BCNU, etoposide, ...
B cells must normally tolerate self-ligands of their pathogen-receptor systems (BCRs and TLRs) and only proliferate in response to foreign ligands for these receptors. The aforementioned experiments reveal that tolerance to nucleic acid-sensing TLRs is disrupted by a somatic mutation in MYD88 that is very frequently found in the benign disorder, IgM monoclonal gammopathy of undetermined significance, and in a range of B cell malignancies. In the absence of foreign TLR ligands, MYD88L265P was sufficient to drive multiple rounds of B cell division provided the Unc93b1-dependent and chloroquine-sensitive steps in TLR9 activation were intact, and provided the B cells were not constantly binding self-antigen. This disruption of normal tolerance to TLR9 has parallels with the effects of weakly activating lymphoma CARD11 mutations, which break normal B cell tolerance to self-ligands of the BCR (Jeelall et al., 2012). However breakdown of TLR tolerance is fortified by more checkpoint mechanisms: ...
This article discusses the fundamentals for measuring the viscosity of whole blood, serum, and plasma and its application to the diagnosis of hyperviscosity syndrome. We describe some of the terminology in the field, including relevant definitions, t
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Hematology and Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab. ...