Can vitamin D deficiency be the culprit behind increase in weight? To know, how vitamin D insufficiency can contribute to weight gain, read the following article. About Buzzle Privacy Policy. Find Out How Weight Gain And Low Vitamin D Levels Are Related. As we all know, vitamin d deficiency and inability to lose weight number of factors are responsible for weight gain. Too little exercise and indulgence in vitamin d deficiency and inability to lose weight foods are the primary reasons why people become overweight.. However, recent studies does eating cottage cheese before bed help you lose weight that vitamin D levels in the body influence weight. Low vitamin D and weight gain are linked and hence vitamin D deficiency needs to be avoided. Low Vitamin D and Weight Gain. Did you know that low vitamin D levels can put you in the risk zone of excess weight gain. According to recent research, people have higher chances of gaining weight if their blood vitamin D levels are persistently low.. Although, ...

TY - THES. T1 - Vitamin D deficiency is associated with airway remodelling and altered lung structure and function. AU - Foong, Rachel Ee Lin. PY - 2015. Y1 - 2015. N2 - The prevalence of vitamin D deficiency is high all over the world and there is now a large body of evidence linking vitamin D deficiency to chronic conditions, including autoimmune, infectious, cardiovascular and respiratory disease. Of relevance to chronic respiratory disease, some studies have shown that vitamin D deficiency is more prevalent in patients with asthma. Lower vitamin D levels are also associated with reduced lung function, increased asthma exacerbations and airway remodelling. In asthma, structural alterations in the lung have origins in early life, and factors that influence lung development may alter lung function and cause an increased susceptibility to disease in the long term. Vitamin D may be a factor affecting lung development, and maternal vitamin D deficiency may therefore contribute to asthma ...

Amy Skversky, M.D., M.S.When doctors write that prescription for steroids and theyre sending the patients for lab tests, they should also get the vitamin D level measured, said study lead author Amy Skversky, M.D., M.S., assistant professor of pediatrics at Einstein and Montefiore Medical Center, the University Hospital for Einstein.. The severe vitamin D deficiency assessed in this study (defined as levels below 10 nanograms per milliliter of blood) is known to be associated with osteomalacia (softening of the bones), rickets (softening of bones in children) and clinical myopathy (muscle weakness). While there is much debate on the issue, vitamin D levels between 20 and 50 ng/ml are generally considered adequate for bone and overall health in healthy individuals. Steroids have been shown to cause vitamin D deficiency, possibly by increasing levels of an enzyme that inactivates the vitamin.. Smaller studies involving people often prescribed steroids (i.e., children with asthma and patients ...

Smokers with low vitamin D concentrations had a higher risk of developing diabetes during their pregnancy than did nonsmokers with adequate vitamin D levels. Both smoking and having low vitamin D levels put women at a greater risk than either risk factor alone. The researchers concluded more investigation is needed to confirm their results and study the interactive effect of smoking and low vitamin D levels.A total of 20 ng/ml (nanograms/milliliter) to 50 ng/ml of vitamin D is considered an average blood level. If the level falls below 12 ng/ml, it is seen as deficient. Vitamin D deficiency could have been what Charles Dickens had in mind when he created Tiny Tim crippled. A deficiency of the vitamin causes rickets in children and osteomalacia in adults: bones can become brittle, thin, or misshapen.. Fortunately, both human skin and mushrooms make vitamin D when exposed to sunlight. So mothers can take in their vitamin D naturally from being outdoors for a few minutes a day without sunscreen, or ...

The results of various studies show severe Vitamin D deficiency across India and Pakistan in all age groups, as well as insufficiency in populations of South-East and East Asia.

Long known for its role in bone development, vitamin D has recently been implicated in a wide range of disorders. Emerging evidence suggests that low vitamin D levels may play a role in the development of certain cancers and heart disease and lead to suppressed immunity, the researchers note.. Anemia, which occurs when the body doesnt have enough oxygen-carrying red blood cells, is believed to affect one in five children at some point in their lives, experts say. Several large-scale studies have found severe vitamin D deficiency in about a tenth of U.S. children, while nearly 70 percent have suboptimal levels. If our findings are confirmed through further research, low vitamin D levels may turn out to be a readily modifiable risk factor for anemia that we can easily tackle with supplements, says senior study investigator Jeffrey Fadrowski, M.D., M.H.S., also a pediatric kidney specialist at Johns Hopkins.. The research was funded by the National Institute of Diabetes, Digestive and Kidney ...

Vitamin D refers to a group of fat-soluble molecules, from which the most important in humans are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol) [1]. A small amount of these can be obtained from the diet, but about 90% comes from synthesis of vitamin D in the skin when exposed to ultraviolet B radiation from the sun [2, 3]. This dermal synthesis depends on the area of skin exposed to sunlight, duration of exposure, latitude, season and skin type [4, 5]. In Sweden, latitude 55-69° North, there is no dermal synthesis of vitamin D during the winter months [1, 4]. Vitamin D has a significant role in mineralization of bone, skeletal maturation, regulating the concentration of calcium and phosphate, therefore severe vitamin D deficiency can cause osteomalacia in adults and rickets in pediatric population [6]. Vitamin D deficiency is a known risk factor causing fractures, osteoporosis and muscle weakness in elderly [5, 7, 8].. Vitamin D deficiency might be associated with reduced ...

It is increasingly being recognized that infants and children living at northern latitudes are at risk of vitamin D deficiency, especially if their skin is darkly pigmented. The study by the PI (Pediatrics 2006;118:603) was the first to demonstrate that infants with light skin pigmentation living at 41 degrees north are at risk of vitamin D deficiency. During winter (December - April) a full 78% of infants were vitamin D deficient if they did not receive vitamin D from an external source. Very few breastfed babies are currently receiving supplemental vitamin D. The recommended dose is 200 IU/day. However, there are questions about the adequacy of this dose of vitamin D for the prevention of vitamin D deficiency. The present trial is designed to determine whether a dose of 200 IU/day is effective or whether doses of 400 IU/day, 600 IU/day or 800 IU/day are required to prevent vitamin D deficiency reliably.. The trial is a randomized, prospective double-blind trial in which breastfed infants will ...

BACKGROUND: People with intellectual disabilities have a high risk of osteoporosis and fractures, which could partly be as a result of vitamin D deficiency. AIMS: To compare the serum vitamin D (25(OH)D) levels of 155 patients with intellectual disabilities under psychiatric care and 192 controls, investigate potential risk factors for vitamin D deficiency in people with intellectual disabilities and assess available treatments. METHOD: Cross-sectional observational study followed by treatment evaluation. Results Almost twice as many patients with intellectual disabilities had vitamin D deficiency (25(OH)D |50 nmol/l) compared with controls (77.3% v. 39.6%, P|0.0001). In the intellectual disabilities group, winter season (P|0.0001), dark skin pigmentation (P|0.0001), impaired mobility (P = 0.002) and obesity (P = 0.001) were independently associated with lower serum 25(OH)D. In most patients, 800 IU colecalciferol daily normalised 25(OH)D levels. CONCLUSIONS: Vitamin D deficiency is highly prevalent in

Severe vitamin D deficiency causes the bones to soften and leads to bone disorders. In children, the most visible sign of vitamin D deficiency is bowed arms and legs. In adults, the most common symptom of vitamin D deficiency is generalized bone and muscle pain. ...

If sun exposure is insufficient, how adequate are the current recommendations to prevent vitamin D deficiency in mothers and children? Although vitamin D supplementation is effective in preventing vitamin D deficiency, the optimal vitamin D requirement in women and children is still unknown.12 21 71 In the past, studies by Delvin et al,72 Mallet et al73 and Cockburn et al74 showed that vitamin D supplements below 2000 IU/day did not effectively prevent deficiency. In pregnant women treated with 1000 IU vitamin D/day, maternal serum 25(OH)D levels ranged from a mean of 9.5 nmol/l at baseline to 25.3 nmol/l after receiving 1000 IU vitamin D/day during the last trimester.73 The post-supplementation value is consistent with the definition of deficiency.21 In a more recent study,75 supplementation of pregnant women belonging to minority groups in the UK with 800-1600 IU of vitamin D during pregnancy increased serum 25(OH)D levels from a mean of 14.5 nmol/l at baseline to only 28 nmol/l at term. In ...

It is recommended to treat patients suspected of vitamin D deficiency empirically. This recommendation is made after due consideration of the drug cost compared to vitamin D laboratory test costs, and the negligible risk of vitamin D3 toxicity at advised doses. If testing is performed, deficiency is noted to be recognised locally as a serum 25OHD level of less than 25nmol/L (less than 10 nmol/L in NDDH and RD&E). Serum calcium levels should be tested before starting a calcium-containing product or treatment dose vitamin D. Specialist advice should be sought before starting patients with granulomatous disease, tuberculosis or active sarcoidosis on vitamin D therapy due to the risk of hypercalcaemia with high doses of vitamin D. All patients should be provided advice on sun exposure and dietary sources of vitamin D (although it should be noted that only a small amount of vitamin D comes from the diet). Patients with vitamin D deficiency may require loading treatment with pharmacological strength ...

In adults, prolonged deficiency of vitamin D (calciferol) can lead to osteomalacia, while lesser deficiency (insufficiency) is associated with various non-specific symptoms. Both vitamin D deficiency and insufficiency are becoming more common in developed countries. In the UK, the prevalence of vitamin D deficiency in all adults is around 14.5%, and may be more than 30% in those over 65 years old and as high as 94% in otherwise healthy south Asian adults. By comparison, the prevalence of vitamin D insufficiency in adults may be as high as 55%, and the condition is even more common in patients with osteoporotic fractures. Recently, we discussed the management of children with primary vitamin D deficiency. Here we review the management of adults with the condition.

This observational study included 52 Scottish women, 25 of whom had polycystic ovary syndrome (PCOS), who were tested for serum 25-hydroxyvitamin D concentrations. Vitamins D concentrations less than 25 nmol/L were classified as severe vitamin D deficiency. Severe vitamin D deficiency was found in 44% of women with PCOS and 11.2% of controls. In the PCOS group, vitamin D levels correlated negatively with body mass index, C-reactive protein and free androgen index and positively correlated with quantitative insulin sensitivity check index, HDL and sex hormone binding globulin.. Metabolism. 2011 May 5. [Epub ahead of print] Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome.. Does this mean that by adding vitamin D we can treat PCOS? Not necessarily. But with how easy it is to supplement with vitamin D, I dont see why we wouldnt add it to the regime.. Kerri. PCOS and Vitamin DRead More ...

There are numerous publications regarding metabolism of vitamin D in humans, but also in other species. These publications often deal with vitamin D metabolism down to the atoms level - not something absolutely needed for somebody wanting to prevent and avoid vitamin D deficiency.. For most people, it is important to know few facts about:. - vitamin D structure - it is based on cholesterol derivative from which body can (when exposed to UVB radiation) produce vitamin D. Daily amounts of needed cholesterol are usually more than enough for normal vitamin D production due to UVB radiation. Also, when needed, body produces its own cholesterol, so lack or low levels of cholesterol (both HDL (good cholesterol) and LDL (bad cholesterol)) in human nutrition cant cause vitamin D deficiency.. - body can produce vitamin D with the help of UVB rays, so moderate sun exposure is good for health and well being. Actually, active form of vitamin D is NOT produced in the skin.. - vitamin D blood levels are ...

Many of your patients may not be getting their recommended daily intake of vitamin D, which could lead to vitamin D insufficiency or deficiency. Vitamin D insufficiency is defined as 25-hydroxyvitamin D (25(OH)D) of 20-29 ng/mL, while vitamin D deficiency is defined as less than 20 ng/mL.1. Physicians typically test for vitamin D in patients who are dark-skinned, have osteoporosis, receive little or no sun exposure, or are advanced in age. But other at-risk patient types may benefit from routine testing, too.1,2. Do you know which lesser-known patient types are at risk of vitamin D deficiency? Take a look at this list and learn how you can help your patients by testing for vitamin D.. ...

Can an extreme vitamin D deficiency increase the risk of developing dementia?. A recent study appearing in the journal Neurology supports the link between severe deficiency in vitamin D and an increased risk of developing dementia.. A team of researchers at the University of Exeter found that the higher the vitamin D deficiency, the higher the risk of developing dementia and Alzheimers disease.. Study participants who were severely Vitamin D deficient were found to be more than twice as likely to develop Dementia and Alzheimers disease.. Research revealed that those who were moderately deficient in vitamin D had a 53 per cent increased risk of developing dementia. This risk increased to 125 per cent in those who were severely Vitamin D deficient.. The research team was led by Dr Llewellyn who has said: We expected to find an association between low Vitamin D levels and the risk of dementia and Alzheimers disease, but the results were surprising - we actually found that the association was ...

The results: Significant different between nurses-midwives knowledge about impact of vitamin D deficiency upon maternal health with demographical characteristics educational level at (p 0.05, p = 0.048). And significant difference between nurses-midwives knowledge about causes and risk factors with demographical characteristics regarding training courses related to Vitamin D at (p 0.05, p = 0.048). Their significant difference between nurses-midwives knowledge about prevention of vitamin D deficiency with demographical characteristics regarding training courses related to obstetrics and gynecology and vitamin D at (p 0.05, p = 0.048 &0.020). And significant different between overall nurses-midwives knowledge about vitamin D deficiency with demographical characteristics regarding educational level at (p 0.05, p = 0.001). ...

In the study of [Vitamin D deficiency and hip fracture].[Article in Dutch] by Lips P, Netelenbos JC., posted in US National Library of Medicine National Institutes of Health, researchers found that The elderly which are institutionalized carry an increased risk. Prevention or vitamin D deficiency is possible by adequate exposure to ultraviolet light. Primarily, the elderly should be encouraged to go out into the sunshine regularly. Advice on nutrition may be given additionally. When sunshine exposure is negligible, as in many disabled and institutionalized elderly, a daily supplement of vitamin D3 400 IU should be given. Preventive measures have to be evaluated prospectively. Vitamin D deficiency is not the most important risk factors for hip fractures, but the easiest to correct ...

NaturalPath) A recent study out of the University of Sheffield shows there may be a link between vitamin D levels and irritable bowel syndrome (IBS).. This study looked at 51 participants all with IBS, and found that 82 percent were vitamin D deficient. When participants rated their quality of life, there also appeared to be an association between vitamin D levels and the severity of the deficiency. For example, those with lower rated quality of life, based on how IBS affects activities of daily living, showed lower vitamin D levels and a greater deficiency.. Although there is no single known cause that is responsible for IBS, these findings suggest there may be a need to consider supplementation of vitamin D in this population. It is also not been confirmed whether vitamin D deficiency is solely a consequence of the disease, but regardless, insufficient vitamin D status should be addressed in patients with IBS. It is suggested that these patients may also benefit from supplementation, as ...

Studies revealed an association between vitamin D deficiency and the frequency of cardiovascular diseases and their risk factors. This review is aimed at summarizing evidence for the association of vitamin D deficiency and vitamin D supplementation with the risk of cardiovascular diseases. The...

TY - JOUR. T1 - Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery. T2 - A Systematic Review. AU - Kerezoudis, Panagiotis. AU - Rinaldo, Lorenzo. AU - Drazin, Doniel. AU - Kallmes, David. AU - Krauss, William. AU - Hassoon, Ahmed. AU - Bydon, Mohamad. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Background Vitamin D deficiency is a relatively common occurrence in patients presenting for spinal surgery; however, whether this abnormality has any effect on spinal fusion outcomes remains unclear. We performed a systematic review of the available literature relevant to the association between vitamin D deficiency and spinal fusion outcomes. Methods We conducted a systematic and critical review of recent literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following databases were searched: MEDLINE/PubMed, Google Scholar, Cochrane, Web of Science, and Scopus. Key search terms were vitamin D, spinal surgery ...

NEW YORK (Reuters Health) - HIV-positive patients taking efavirenz are at risk for clinically significant vitamin D deficiency, and for excessive bone turnover if they are taking tenofovir, a UK group reports in a June 25 advance online issue of AIDS. Dr. Frank A. Post at Kings College London School of Medicine and colleagues with Kings...

Zosky adds because of the nature of the study its not known if the changes in lung function and structure were from vitamin D deficiency in the mother that occurred in utero, or a direct result.. The researchers say the study supports past epidemiological studies suggesting low vitamin D levels contribute to asthma and COPD.. The differences we observed in lung volume and lung mechanics, which were substantial and physiologically relevant, raise serious concerns regarding the increased prevalence of vitamin D deficiency in communities around the world. The results also raise concerns about the potential this deficiency may have on lung health, and in particular, the potential impact deficiency may have on the susceptibility to obstructive lung disease.. The study is the first to to show the causal relationship between low levels of vitamin D and altered lung function and structure. The researchers suggest more studies. Supplementing vitamin D might improve lung health for susceptible patients ...

Results Serum vitamin D3 assessment was available for 85.4% (158/185) patients during the previous 12 months. First measured vitamin D3 levels were used for primary analysis showing a mean clinic vitamin D3 level of 45.1nmol/L. Normal vitamin D3 levels (,72nmol/L) occurred in 18.9%, 14.6% had insufficient levels (52-72nmol/L) and 65.5% had deficient levels (,52nmol/L). Severe deficiency (,20nmol/L) occurred in 14.6%. Vitamin D deficiency showed highest prevalence during Winter, Autumn and Spring(83-79%) and lowest level in Summer (53.3%). Two thirds of patients received a course of vitamin D replacement therapy during the year.. Vitamin D deficient showed no difference compared to normal vitamin D3 status patients in atopic status, spirometry, inhaled medication usage, maintenance oral steroid use, Omalizumab use and asthma hospitalisations. No significant difference was observed between the two groups in respect to comorbidities like GORD, rhinitis, COPD, bronchiectasis, food allergy and ...

Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Methods: The study was conducted on 85 patients with differentiated thyroid cancer diagnosed based on fine needle aspiration biopsy as the case group and 85 healthy controls. Serum levels of vitamin D were evaluated before thyroidectomy. For each patient in the case group, one healthy euthyroid person without any thyroid nodules from the general population matched based on season, sex, age (± 1 year) and BMI (± 1) was selected. Finally, 85 pairs were obtained considering inclusion and exclusion criteria. Thyroid function, thyroid antibodies and serum vitamin D were assessed and thyroid sonography was performed in all participants. Results: In the patient group, 72 (85%) were female and

Calcium absorption is regulated by both active (transcellular) and passive (paracellular) pathways. Although each pathway has been studied, correlations between the two pathways have not been well elucidated. In previous investigations, the critical transcellular proteins, calbindin-D9k (CaBP-9k) and -D28k (CaBP-28k), were shown to affect other transcellular pathways by buffering intracellular calcium concentrations. The rate of paracellular calcium transport in the duodenum is generally determined by the expression of tight junction genes. In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined. With a normal diet, the expression of most tight junction genes in the duodenum was significantly increased in CaBP-9k knockout (KO) mice compared to wild-type (WT) animals. With a calcium- and vitamin D-deficient diet, tight

We have conducted what is to our knowledge the first large, prospective, population-based study to examine vitamin D concentrations in relation to a comprehensive adjudicated assessment of dementia and AD. We observed a strong monotonic association between 25(OH)D concentrations and the risk of both incident all-cause dementia and AD. This association was robust to adjustment for a range of potential confounders and the exclusion of dementia cases that occurred within a year of baseline.. The 2 previous studies that have investigated vitamin D and incident dementia have produced conflicting results. The first found that severe vitamin D deficiency was associated with non-AD dementia but not AD risk.16 The second found that severe vitamin D deficiency was associated with AD but not vascular dementia risk.17 However, the first study incorporated a small sample of high-functioning women (n = 40), and the lack of association with AD may reflect limited statistical power. The second study relied on ...

We have conducted what is to our knowledge the first large, prospective, population-based study to examine vitamin D concentrations in relation to a comprehensive adjudicated assessment of dementia and AD. We observed a strong monotonic association between 25(OH)D concentrations and the risk of both incident all-cause dementia and AD. This association was robust to adjustment for a range of potential confounders and the exclusion of dementia cases that occurred within a year of baseline.. The 2 previous studies that have investigated vitamin D and incident dementia have produced conflicting results. The first found that severe vitamin D deficiency was associated with non-AD dementia but not AD risk.16 The second found that severe vitamin D deficiency was associated with AD but not vascular dementia risk.17 However, the first study incorporated a small sample of high-functioning women (n = 40), and the lack of association with AD may reflect limited statistical power. The second study relied on ...

The study, presented at the American Society of Anesthesiologists 2007 Annual Meeting in San Francisco, found that one in four patients who suffer from chronic pain also have inadequate blood levels of vitamin D. As such, the researchers put forth that the vitamin D deficiency possibly contributed to the patients ongoing pain. Vitamin D deficiency - which can lead to osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases - s been found to be lacking particularly in inhabitants of colder climates. A recent study, for example, indicated that the median adult intake of vitamin D in the US is only 230 IU per day, versus the researchers recommended 2000 IU per day. The latest study, undertaken at the Mayo Comprehensive Pain Rehabilitation Center in Rochester, Minnesota, involved 267 adults undergoing outpatient treatment for chronic pain. The researchers recorded their serum vitamin D levels, pain medication ...

The present study is one of the few studies investigating vitamin D status in the pediatric population in the southern region of the United States. In particular, this study is the first to address 25-hydroxyvitamin D levels over 4 seasons in a cohort of black and white adolescents living at southern US latitudes. Our data demonstrate that low vitamin D status is common among adolescents residing in the southeastern region and is related to various adiposity and lifestyle factors.. From NHANES III (1988-1994)2 to NHANES 2000-2004,2,24 the prevalence of vitamin D deficiency (25-hydroxyvitamin D levels of ≤50 nmol/L) in black and white adolescents increased from 28% to 48% and that of vitamin D insufficiency (25-hydroxyvitamin D levels of ≤75 nmol/L) increased from 66% to 81%. More importantly, ∼70% of the black adolescents in NHANES 2000-2004 had winter serum vitamin D deficiency, which might have important implications for known health disparities.24 The NHANES provided key information ...

The primary aims of this study are to assess if there is any association between the mean levels of vitamin D in various countries and the mortality caused by COVID-19. The secondary aim was to identify if there is any association between the mean vitamin D levels in various countries and the number of cases of COVID-19.. To limit confounding biases (eg, latitude), they focused on 20 European countries hit by Coronavirus-19. The researchers searched the health literature for the mean levels of vitamin D among the citizens in each country. Then they compared those figures with the numbers of COVID-19 deaths in each country as of 20 March 2020. The researchers defined severe Vitamin D deficiency as a serum blood level lower than 30 nmol/L. (30 nmol/L = 12 ng/mL - ie, a very serious deficiency. Charts Ive seen show the deficiency cut off at somewhere between 30-50 ng/mL so 12 ng/mL is very serious.). The data demonstrated very significant correlations between the mean Vitamin D levels and the ...

During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed, rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review, we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however, there is evidence

Natural Ways to Cure Vitamin D Deficiency. There are natural ways to cure and prevent Vitamin D deficiency. This means that you can easily correct this deficiency at home or just outside the house.. Soaking Up the Sunlight. Vitamin D has two forms - vitamin D2 and D3. The skin produces vitamin D3 when exposed to ultraviolet B rays from the sun. Exposing the body to the sun allows it to get enough vitamin D, which can help prevent cancer, periodontal disease, multiple sclerosis, cardiovascular disease, depression and schizophrenia. Moreover, it can reduce the risk of diabetes and the severity of asthma.Soaking the skin for about 15 minutes in the morning without wearing a sunscreen can help. The darker the skin, the longer exposure to sunlight is required to get the amount of vitamin D needed by the body.. ...

You know that our digestive system plays perhaps the most important role in our health-it recognises the nutrients in the food that we eat, separates them from the rest and creates energy for the body. But did you know that mitochondria perform a similar function at a cellular level? Any improvement in mitochondrial function is beneficial to our wellbeing.. According to new research from Newcasle University, Vitamin D is vital for mitochondria to work well and good Vitamin D levels help improve our energy levels as well as keep our muscles working efficiently.. For the study, the team employed non-invasive magnetic resonance scanning to measure the energy levels and muscle fatigue of 12 patients with severe vitamin D deficiency. They were again tested after being given Vitamin D supplements.. Examining this small group of patients with vitamin D deficiency who experienced symptoms of muscle fatigue, we found that those with very low vitamin D levels improved their muscle efficiency ...

Vitamin D is an essential nutrient for bone homeostasis that has also been implicated in numerous other disorders, such as cardiovascular disease (CVD) and autoimmune diseases. Originally vitamin D deficiency was associated only with rickets and it was considered that the fortification of food resolved this disorder. However, it is now realised that rickets represents just one manifestation of vitamin D deficiency.1,2 The recommended Dietary Reference Intakes are solely based on the skeletal effects of vitamin D, with the recommended dietary allowance (RDA) ranging from 400 to 800 IU/day depending on age as recommended by the Institute of Medicine to maintain blood levels of 25-hydroxyvitamin D (25[OH]D) of at least 50 nmol/L (20 ng/mL). However to achieve non-skeletal benefits of vitamin D, a multitude of studies have suggested that maintenance of a level of 25[OH]D >30 ng/mL may be required. The majority of primary care clinicians are not aware of the recommended dose for vitamin D ...

While moderate to severe vitamin D deficiency is prevalent in Saudi Arabia, skeletal effects associated with this deficiency are not common in this population. In this interventional study we measured the effects of improving vitamin D status on bone biochemical markers in overweight and obese adult Saudis. A total of 47 volunteers (21 males, 26 females) out of the initial 95 subjects were given verbal advice to expose themselves to sunlight for 5-30 min twice weekly and were encouraged to increase their intake of vitamin D-rich foods. Serum 25(OH)D, osteocalcin, and type 1 collagen cross-linked C-telopeptide (CTx), were measured at baseline and after one year. A significant decrease in the prevalence of vitamin D deficiency was observed (44% to 27%) after one year follow-up (p = 0.025). Also, a parallel significant increase in osteocalcin and a decrease in CTX and osteoprotegerin were observed. The results suggest that a modest increase in vitamin D levels among overweight and obese subjects through

Several clinical studies indicate that low vitamin D status is significantly associated with a high risk or severity of OM [12131415]. A recent case-control study by Cayir et al. [12] showed that the mean serum 25(OH)D level was significantly lower in children with recurrent OM compared with controls (28.5 nmol/L vs. 72.9 nmol/L). Another case-control study by Walker et al. [13] also showed that children with a higher serum 25(OH)D level carried a lower risk of chronic OM with effusion (odds ratio, 0.86 per 10 nmol/L; 95% confidence interval, 0.77 to 0.97). In a randomized controlled trial, administration of vitamin D 1,000 IU per day for 4 months significantly reduced the risk of uncomplicated acute OM in children with a history of recurrent acute OM (hazard ratio, 0.23; 95% confidence interval, 0.12 to 0.46) [14]. In addition, a meta-analysis of five clinical studies involving 16,689 subjects concluded that the lower vitamin D level might play an important role in increasing the occurrence of ...

Vitamin D deficiency can result from inadequate nutritional intake, inadequate exposure to sunlight or malabsorption. Vitamin D is important for calcium homeostasis and for optimal skeletal health. A deficiency results in impaired bone mineralization and leads to osteomalacia, or rickets when diagnosed in children. The amount of vitamin D recommended for all infants, children and adolescents is 600 IU per day. The flesh of fatty fish, beef liver, cheese and egg yolks are among the best sources.… Vitamin D Deficiency (Deficiencies Vitamin D): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.

Vitamin D Deficiency. Despite the fact that there are many sources of vitamin D, many people still dont get enough amount of it, thereby leading to a deficiency in this vitamin.. An average adult requires about 200 IU (International Unit) of vitamin D per day. The older an adult is, the higher amount of vitamin D he needs to maintain strong bones.. Vitamin D deficiency is associated with colon cancer, breast cancer, prostate cancer, depression, heart disease and weight gain. Several studies show that people with high levels of vitamin D have lower risks of developing these diseases.. ...

It has become increasingly recognized that low vitamin D levels are prevalent worldwide and to a more severe degree in the Middle East. Low vitamin D levels are associated with an increased risk of osteoporotic fractures, and of chronic conditions such as autoimmune disorders, diabetes, cancer, and the metabolic syndrome. Obese individuals are more likely to have low vitamin D levels, and in some studies obesity was a risk factor for fractures in both the young and elderly. Our group has investigated the impact of vitamin D therapy in the young, and preliminary data suggest that doses exceeding the currently updated recommended estimated average requirement (EAR) of 400IU for that age group may be more beneficial for bone health. The updated EAR recommendations by the IOM for any age group, although believed to cover the needs of all individuals in each age group, are limited by the lack of good evidence supporting such recommendations. Therefore, to-date, the optimal dose of vitamin D for both ...

37.5° latitude), obese patients, and those on certain medications. To maintain blood levels of calcium, therapeutic vitamin D doses are sometimes administered (up to 100,000 IU or 2.5 mg daily) to patients who have had their parathyroid glands removed (most commonly kidney dialysis patients who have had tertiary hyperparathyroidism, but also to patients with primary hyperparathyroidism) or with hypoparathyroidism. Patients with chronic liver disease or intestinal malabsorption disorders may also require larger doses of vitamin D (up to 40,000 IU or 1 mg (1000 micrograms) daily). The estimated percentage of the population with a vitamin D deficiency varies based on the threshold used to define a deficiency. Recommendations for 25(OH)D serum levels vary across authorities, and probably vary based on factors like age; calculations for the epidemiology of vitamin D deficiency depend on the recommended level used. A 2011 Institute of Medicine report set the sufficiency level at 20 ng/ml (50 nmol/l), ...

Black people are frequently treated for vitamin D deficiency, but we may not be measuring the right form of vitamin D to make that diagnosis, says Thadhani, who is senior and co-corresponding author of the NEJM report. While our finding that 80 percent of black participants in this study met criteria for vitamin D deficiency is consistent with previous studies, we were surprised to find no evidence of problems with bone health. Most vitamin D in the bloodstream is tightly bound to D-binding protein and is not active. When we determined the concentrations of circulating non-bound vitamin D, which would be available to cells, we found that levels of this form were equivalent between black and white participants, which suggested to us that these black individuals may not be truly deficient ...

Supplementation to raise vitamin D levels does not improve lipids. The investigators also performed a longitudinal analysis to assess the impact of therapy to correct vitamin D deficiency on lipid levels. Longitudinal studies evaluate changes in a study population over time. Pharmacological, oral vitamin-D therapy is typically administered to raise vitamin D levels in patients with vitamin D deficiency, although over-the-counter supplements are also widely available. The longitudinal study examined data for 8,592 patients re-tested between four and 26 weeks. It showed that raising vitamin D levels from deficient to optimal levels had no statistically significant effect on LDL cholesterol or triglycerides, and had a small, but clinically minimal impact on total and HDL cholesterol. The seemingly conflicting findings of the cross-sectional analysis and longitudinal analysis suggest that while vitamin D deficiency is associated with an unfavorable lipid profile, correcting a deficiency through ...

70 years: 15 µg/day Day to day requirements of vitamin d are set around 800-1000IU to maintain healthy levels which in most cases can be provided by sun exposure. Increased amounts are required for individuals who are previously diagnosed as deficient. For those of moderate deficiencies,oral supplementation can be implemented into the diet at levels of 3000-5000 IU per day for a 6- to 12-week period continued by an ongoing reduced dose of 1000- 2000 IU per day to maintain stores in the body. Severe deficiency is treated through megadose therapy where patients are given doses around 100 000 IU to assist in raising stores faster to ensure physical health in restored to prevent further illness or disease. Vitamin D deficiency Vitamin D Sun exposure Australian Health Survey: Biomedical Results for Nutrients, 2011-12 (PDF). Shrapnel, William; Truswell, Stewart (2006-12-01). Vitamin D deficiency in Australia and New Zealand: What are the dietary options?. Nutrition & Dietetics. 63 (4): 206-212. ...

Vitamin D deficiency is often known to provoke certain heart diseases. According to medical experts, when vitamin D levels are low, the calcium levels in the arteries are higher and thus heart problems arise. The calcium creates clogs inside the arteries, which usually leads to a heart failure or a stroke.. Aside from the listed, other health conditions that may occur as a result of vitamin D insufficiency are: type 2 diabetes, high cholesterol and obesity.. Incorporating More Vitamin D. Getting to know the health issues which can happen if vitamin D is missing from the body, forces us to rethink our nutrition and get those vitamin levels back on track.. Here are the top products full of vitamin D, which, if consumed regularly, will never fail you. Take them regularly and keep your health on the right path: ...

BACKGROUND:. First Nations children are at higher risk for vitamin D deficiency and rickets.. OBJECTIVE:. To assess the prevalence of vitamin D deficiency and the correlations between fat mass, parathyroid hormone and dietary habits with serum vitamin D level in a random sample of Cree children eight to 14 years of age.. METHODS:. Serum 25-hydroxyvitamin D (25[OH]D) levels and additional information regarding anthropometrics and dietary habits were obtained from participants in two Cree communities. Vitamin D deficiency and insufficiency was defined as serum 25(OH)D levels ,30 nmol/L and ,50 nmol/L, respectively.. Proportions to estimate the vitamin D status were weighted to account for the complex sampling design, and Pearsons correlation coefficients were used to estimate the associations of milk and fish intake, parathyroid hormone and fat mass with serum 25(OH)D levels.. RESULTS:. Data from 52 healthy Cree children (mean [± SD] age 11.1±2.0 years; 27 boys) were included in the analyses. ...

20 percent of the middle-aged UK South Asian population may have a very severe vitamin D deficiency, a new study in the British Journal of Nutrition reports. Such deficiency can lead to health problems such as osteomalacia (softening of the bones) and other chronic diseases.

TY - JOUR. T1 - Serum vitamin D concentrations and unexplained elevation in ALT among US adults. AU - Liangpunsakul, Suthat. AU - Chalasani, Naga. PY - 2011/7. Y1 - 2011/7. N2 - Background: Low serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT. Methods: A total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels. Results: Participants with unexplained elevation in ALT had significantly lower serum ...

TY - JOUR. T1 - The combination of vitamin D deficiency and mild to moderate chronic kidney disease is associated with low bone mineral density and deteriorated femoral microarchitecture. T2 - Results from the knhanes 2008-2011. AU - Lee, Yong Ho. AU - Kim, Jo Eun. AU - Roh, Yun Ho. AU - Choi, Hae Rim. AU - Rhee, Yumie. AU - Kang, Dae Ryong. AU - Lim, Sung Kil. N1 - Publisher Copyright: Copyright © 2014 by the Endocrine Society.. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Context: Although mild to moderate chronic kidney disease (CKD) and vitamin D deficiency are prevalent in the elderly population worldwide and are associated with sarcopenia, their influence on bone mineral density (BMD) has not been determined.Objective: The objective of the study was to determine the combined effects of vitamin D deficiency and CKD on BMD in the elderly population and their relationships with sarcopenia and PTH levels.Design, Setting, and Subjects: This was a cross-sectional study with nationally representative ...

We have previously demonstrated that 80% of patients with PTHP will have co-existing vitamin D deficiency suggesting an increased metabolism of vitamin D. There are few data assessing the impact and safety of different vitamin D preparations on calcium, parathyroid hormone (PTH) and vitamin D in this group. Here, we report the details of replacement therapy using different vitamin D preparations.. In a retrospective study of 22 (20 F:2 M and 8 Asian:14 Non-Asian) patients with confirmed PTHP and vitamin D deficiency, we assessed the impact and safety of treatment with osteo-D2 50 000 IU after four-eight weeks (n=8), calcium and vitamin D (e.g.Adcal-D3) twice daily for three months (n=6) and over the counter (OTC) vitamin D 1000 IU/day (n=6) or cod liver oil (n=2) for three months, on serum calcium, PTH and vitamin D levels.. Results: Mean (±SD) serum calcium was statistically significantly increased after treatment in the group as a whole (2.7(±0.23) vs 2.75 (±0.28) mmol/l; P,0.05) and also ...

A recent study has found a further link between low vitamin D levels and premenopausal breast cancer.The study, by researchers from the University of California, San Diego School of Medicine, examined 1,200 healthy women and found that those whose serum vitamin D levels were low during the three-month period just before diagnosis had approximately three times the risk of breast cancer as women in the highest vitamin D group. Several previous studies have shown that low serum levels of vitamin D are associated with a higher risk of premenopausal breast cancer.

Low serum vitamin D [25(OH)D] has been associated with different health problems worldwide. However, its causal role in several diseases remains unclear. We aimed to correlate vitamin D status with maternal and neonatal outcomes in pregnant females. One thousand pregnant women were recruited during early labour from the labour ward of King Khaled University Hospital, Riyadh, Saudi Arabia. Detailed medical data of all participants were collected from their records. Delivery events and birth outcomes were also documented. Serum 25(OH)D levels were measured using an enzyme-linked immunosorbent assay. A receiver operating characteristic (ROC) curve was constructed to evaluate the ability of vitamin D levels to predict complicated pregnancies. Regression analysis was used to test the correlation between serum 25(OH)D levels and different variables. Most of the participants were Saudis (89.9 %) and housewives (85.1 %) and 86.4 % of them had vitamin D deficiency (mean: 30.46 ± 19.6 nmol/L). Gestational

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting the women of reproductive age. Vitamin D deficiency may have a role in etiopathogenesis of PCOS and its metabolic and endocrine dysregulations. Various studies have shown conflicting results regarding role of vitamin D in PCOS. Therefore, the aim of this study was to find out vitamin D status in PCOS and its association with various metabolic dysregulations. Methods: This single center prospective case control study included 100 females with PCOS and 100 controls. Participates were evaluated for vitamin D status. Correlation of vitamin D with metabolic dysregulations in PCOS was then done. Results: Vitamin D deficiency was seen in 102 (51%) participants. Vitamin D levels were lower in PCOS group compared to control group (20.9 ± 10.2 vs 27.0 ± 15.6, P value 0.001). Prevalence of Vitamin D deficiency was also more in PCOS group compared to control group (59% vs 43 %, P value 0.024).Vitamin D levels were ...

Vitamin D is a fundamentally important hormone involved in calcium absorption, bone mineralization and parathyroid hormone production. Vitamin D deficiency may result in a myriad of diseases, such as osteomalacia, rickets and has more recently been identified as a risk factor for diabetes. Accurate determination of serum vitamin D levels is, therefore, paramount when assessing an individual for related pathologies against an appropriate reference range for interpretation. The purpose of this study was to assess vitamin D status between healthy Caucasian and healthy Asian populations of Peterborough, taking into account seasonal serum vitamin D variation. In addition, we evaluated whether a reference range for serum vitamin D of the local population should be race and/or seasonal specific. Using a Chromsystems high-pressure liquid chromatography vitamin D2/D3 methodology upon Agilent 1100 hardware, serum vitamin D status was assessed in 200 subjects of varying age, gender and ethnicity using ...

Background and Objective: Low Vitamin D levels have been implicated as contributing to statin myalgia, but studies on the relationship between Vitamin D and statin-associated muscle side effects (SAMS) have produced discrepant results. We examined the influence of baseline and change in Vitamin D levels in patients with self-reported statin myalgia who developed muscle symptoms during a statin-placebo cross-over trial.. Methods: Statin myalgia was verified in 120 patients with prior statin muscle complaints using an 8-week randomized, double-blind crossover trial of simvastatin (SIMVA) 20 mg/d and placebo. Anthropometrics, medical histories, demographics and serologic data (including 25 (OH)Vitamin D) were measured at each phase of the trial.. Results: Forty three (35.8%) patients met the study criteria for myalgia, experiencing muscle pain on SIMVA but not placebo. Serum Vitamin D levels (mean ± standard deviation) prior to simvastatin treatment were not different between patients who did ...

Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offsprings bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Womens Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks gestation [r = -0.16, 95% confidence interval (CI) -0

Plasma 25-hydroxy cholecalciferol (25-OH vitamin D) concentrations were measured in 31 adult Saudi Arabian women who presented with acute minor illness. Patients with chronic diseases, malignancy and overt metabolic bone disease were excluded from this study. The median plasma 25-OH vitamin D concentration was 6 ng/ml (range: 2-18 ng/ml). Only three subjects had a concentration within the normal range (10-55 ng/ml). Plasma 25-OH vitamin D concentrations were significantly lower in subjects living in apartments than in those living in villas or rural areas (P less than 0.02). When direct questioning was used to assess exposure to sunlight, plasma 25-OH vitamin D concentrations were significantly lower in those subjects whose average exposure was less than 30 min daily than those whose exposure was more than 30 min daily (P = 0.002). Our findings confirm the importance of inadequate exposure to sunlight in the aetiology of vitamin D deficiency. Social customs may contribute to this deficiency in ...

Vitamin D deficiency is a global epidemic and has been linked to chronic diseases, with research finding a higher prevalence of these diseases in those who are deficient in vitamin D. Previous research has also shown that vitamin D supplementation helps reduce the risk of influenza. Viral infections often occur in the winter when vitamin D levels are the lowest and supplementation is often required in order to reach normal concentrations.. In a review published two weeks ago in Nutrients, researchers investigated vitamin Ds potential effect in helping to reduce the risk of respiratory tract infections. According to this review, a vitamin D deficiency has been associated with an increased risk of acute respiratory distress syndrome as well as chronic disease. An observational study in Connecticut which included 198 healthy adults in the fall and winter of 2009 through 2010 demonstrated a reduced risk of acute respiratory tract infections in those with a vitamin D insufficiency. Only 17% of ...

Background: Hydroxymethylglutaryl‑coenzyme A reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. The purpose of this study was to determine the effect of simvastatin on serum Vitamin D status in dyslipidemic patients as Vitamin D status has an impact on monocyte/macrophage function and may also contribute to cardiovascular risk. Methods: Selected individuals (n = 102) were treated with simvastatin (40 mg/day), or matching placebo in a randomized, double‑blind, placebo‑controlled, crossover trial. Each treatment period (with simvastatin or placebo) lasted for 30 days and was separated by a 2‑week washout phase. Serum Vitamin D concentration was assessed pre‑ and post‑treatment. Results: Seventy‑seven completed the trial, noncompliance with the study protocol and drug intolerance or relocation were the causes for drop‑out. No significant ...

Introduction: Vitamin D deficiency is still a common serious health problem among women of reproductive age and their infants in developing countries at the outset of the third millennium. Information on vitamin D status of urban lactating women in Islam Abad Gharb is not available, but it seems that, as in other physiologic groups in other areas of Iran, vitamin D deficiency may be common there, too. The aims of this study were: 1) To determine the serum 25-hydroxyvitamin D concentration and its association with independent variables (age, occupation, family size), and 2) To determine the vitamin D status of urban lactating women and its association with the independent variables. Materials & Method: In this descriptive analytical cross-sectional study, using a simple randomized sampling technique, a total of 155 lactating women, whose babies were less than 12 months, were selected from 8 urban health centers in Islam Abad Gharb in winter 2004. A general questionnaire was completed to obtain ...

The only disease associated with vitamin D deficiency not more common in blacks than whites is osteoporosis. Every other disease associated with vitamin D deficiency is more common in African Americans. Vitamin D deficiency may explain why black babies are more than twice as likely as whites to have low birth weights. [xiii] Of the children diagnosed with vitamin D deficiency rickets in the United States over the last 17 years, 83% were African American. [xiv] Infants derive their vitamin D from breast milk but most nursing moms are so low in vitamin D that they are unable to excrete adequate amounts into their milk. Nursing women need about 4000 IU of vitamin D a day to make breast milk adequate for their infants. The breast milk of black women often has undetectable levels of vitamin D. [xv] [xvi] It takes a white woman about five minutes of full body sun exposure a day to make this much vitamin D. The only significant food source for vitamin D is milk. The government requires dairies to ...

Instead of 3 large and the large room with about their gallbladder does not empty regular coffee and cannot determine the future. When the patients, pain in the body lies in cotact with antibiotics alone, Ms. If you want is for informative purposes only, and refined grains. Many experts believe that the little acid reflux hazardous for this kind of surgical sludge in the gallbladder gallstones pictures critical care. A wrong diet consisting out of stomach disorders. Gallbladder removal, be it major or minor in nature. What You Eat Affects vitamin d deficiency and elevated liver vitamin d deficiency and elevated liver enzymes enzymes GallstonesMost people become anxious when surgery, and other supplements. tattoo removal cost laser This is because the liver and the underlying organs. This is important to take a muscle relaxant and lower back, the affected tissue. People who develop arthritis in their final signs of liver failure entire life. It would come and seldom people with gallstones in 24 ...

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Effects of low vitamin D level On Body - Vitamin D is crucial for strong and healthy bone and also the teeth. Lacking the recommended amounts in...

TY - JOUR. T1 - Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. AU - Mahon, B. D.. AU - Gordon, S. A.. AU - Cruz, J.. AU - Cosman, F.. AU - Cantorna, M. T.. PY - 2003/1/1. Y1 - 2003/1/1. N2 - Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17±6 ng/ml at baseline to 28±8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-β1 levels from 230±21 pg/ml at baseline to 295±40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-β1 levels. Tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not ...

In this study, data were available with 451 kidney stone cases and 482 controls for the analysis. This work provided convincing evidence that serum vitamin D level in kidney stone patients was significantly higher than that in non-kidney stone controls. The associations were also significant both in Europe and in Asia populations.. In our study, significant between-study heterogeneity was found between serum vitamin D levels and kidney stone risk. Previous paper [21] had reported that heterogeneity is common in the meta-analyses. To explore the potential sources of between-study heterogeneity is therefore an essential component of meta-analysis. The high degree of heterogeneity might have arisen from publication year, study design and geographic locations. Therefore, we used meta-regression to explore the causes of heterogeneity by covariates. However, no covariate had significant impact on the high between-study heterogeneity among those mentioned above. Considering the pooled meta-analysis was ...

BACKGROUND: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with ... read more vitamin D insufficiency/deficiency. METHODS: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (,50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D ,50 nmol/l) was reached in ,75% without side effects nor reaching toxic levels. RESULTS: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency ...

The mean of serum 25(OH)D3 level was 22.80 ± 16,23 ng/mL.14 patients (25.5%) had vitamin D deficiency (,10 ng/mL), 34 patients (61.8%) had vitamin D insufficiency (10-30 ng/mL), and 7 patients (14.7%) had normal vitamin D levels. There were significant difference level of anti-dsDNA antibodies (112.46 vs 267.13 U/ml; p , 0.05) and IgM ACA (16.40 vs 29.7 IU/ml; p , 0,05) in patients with vitamin D insufficiency and vitamin D defisiency. Serum level of 25(OH)D3 were negatively related with level of anti-dsDNA and IgM ACA (r: - 0, and r: - 0,72 respectively). The mean of SLEDAI was 15,0 + 10.46. Serum vitamin D levels were inversely correlated with SLEDAI (R=-0.319, p,0.05). Normal BMD at lumbal spine found in 21 (38.2%) patients. 26 patients (47.3%) were osteopenia, and 8 (14.5%) patients were osteoporosis. At femoral neck, 25 (45.5%) patients had normal BMD, 23(41.8%) patients were osteopenia, 7 (12.7%) patients were osteoporosis. There were no significant correlation between vitamin D level and ...

By Mark, Sean Gray-Donald, Katherine; Delvin, Edgard E; OLoughlin, Jennifer; Paradis, Gilles; Levy, Emile; Lambert, Marie BACKGROUND: Adequate vitamin D status is important for bone growth and mineralization and has been implicated in the regulation of autoimmunity, metabolic function, and cancer prevention. There are no reports of population-based studies on the vitamin D status of Canadian youth, a population with mandatory fortification of foods. METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D], the best indicator of vitamin D status, in a school-based cross- sectional sample of representative French Canadian youth (n = 1753) ages 9, 13, and 16 years living in Quebec (latitude: 45[degrees]- 48[degrees]N). Blood samples were collected from January to May 1999. We defined 25(OH)D deficiency as =27.5 nmol/L, hypovitaminosis as =37.5 nmol/L, and optimal as ,75.0 nmol/L. RESULTS: More than 93% of youth in each age and sex group had suboptimal 25(OH)D concentrations. The prevalence of ...

Results We studied 117 Participants, 62 females and 55 males, age was 71 (5) years, of who 61 received 3,750 IU of vitamin D, and 55 received 600 IU/day. Vitamin D receptor genetic polymorphisms distribution was comparable in both arms. Daily vitamin D intake excluding provided supplements was 7.59 (1.21) mcg and 8.53 (1.36) mcg from the 24 h recall, and food frequency questionnaires, respectively (p was NS between the two arms). Calories, calcium, protein, carbohydrate and fat mean intake was also similar across both arms. The high-dose group achieved significantly higher 25OH-vitamin D serum levels at twelve months 34.9 (9.3) ng/ml compared to low-dose, 21.9 (6.1) ng/ml (p,0.0001). Difference between arms remained significant adjusting for gender, baseline BMI, Fok, Bsml and Taq genetic polymorphism, baseline serum vitamin D and dietary intake of vitamin D, calcium, calories, proteins, carbohydrates and fats. None of these dietary intake measures was found to have significant contribution to ...

INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between ...

Based on epidemiological case-control studies, vitamin D deficiency is now recognized as an independent environmental risk factor for developing multiple sclerosis (MS). Studies indicate that vitamin D, besides regulating bone homeostasis, has immunomodulatory properties thought to be beneficial in MS. It is therefore an attractive and fairly safe candidate for add-on therapy. Certain studies also point towards an inverse correlation between serum vitamin D levels and MRI disease activity or relapse rate in MS patients [1, 2]. However, is there a rationale for vitamin D supplementation in MS patients specifically, besides correcting a documented serum deficiency? One can argue that vitamin D deficiency is also present in a large proportion of the general population in the Northern hemisphere, because of insufficient sunlight exposure, and therefore, supplementation should not be restricted to MS patients only. The article by Faridar et al. in this issue of Acta Neurologica Belgica provides a critical

Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (n = 15) or 4 days of high-dose oral cholecalciferol (n = 64). Ninety-one percent of children with SCA had 25-OHD levels ,20 mu g/L. The 25-OHD levels were negatively correlated with increasing age (P ,0.001) but showed no significant relationship to laboratory measurements, transcranial Doppler velocities or hospital attendance. Both intramuscular ...

Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations in 33 996 individuals of European descent from 15 cohorts. Five epidemiological cohorts were designated as discovery cohorts (n=16 125), five as in-silico replication cohorts (n=9367), and five as de-novo replication cohorts (n=8504). 25-hydroxyvitamin D concentrations were measured by radioimmunoassay, chemiluminescent assay, ELISA, or mass spectrometry. Vitamin D insufficiency was defined as concentrations lower than 75 nmol/L or 50 nmol/L. We combined results of genome-wide analyses across cohorts using Z-score-weighted meta-analysis

What is the optimal vitamin D level?. As already mentioned, different sources recommend different vitamin D levels - currently there is no clear opinion. Official bodies, such as the German Nutrition Society, recommend a vitamin D level of 20 ng/ml. While the Institute of Medicine considers a level of 20 ng/ml to be sufficient, the minimum vitamin D level recommended by the Vitamin D Council is 40 ng/ml. The Grassroots Health initiative recommends a level of 40-60 ng/ml. Dr. Raimund von Helden is convinced that an optimal vitamin D level is between 50-90 ng/ml.. It can now be assumed that the average value should be around 30 - 80 ng/ml. However, the optimal value for a vitamin D level is above 50 ng/ml in almost all studies.. The vitamin d rapid self-test from kiweno interprets vitamin D values as follows:. 0-10 ng/ml - severe deficiency. 11-30 ng/ml - deficiency. 31-100 ng/ml - optimal supply. , 100 ng/ml - Overdose. Vitamin D filling up and maintenance. In the case of a severe deficiency, we ...

In a recent correlation study, people that suffer from ankle and foot injuries are more likely to also be deficient in vitamin D. This correlation between vitamin D deficiency and risk for foot and ankle injuries might serve to offer some dietary advice to athletes, the elderly, and others who are at higher risk of bone damage.. Vitamin D can act as both a nutrient and a hormone in the human body. Traditionally it has been touted as one of the main actors in helping to build and repair bone. However other research has indicated that this vitamin is also useful for reducing the risk of chronic conditions such as heart disease, cancers, multiple sclerosis, and infectious diseases.. In practice vitamin D can be relatively difficult to acquire in the doses necessary for promoting health. While dairy products and fatty fishes contain vitamin D, many Americans do not consume these foods regularly enough to meet their daily intake requirements. In an effort to address this, some foods such as breakfast ...

Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from ≥25 to ≥50 nmol/L (≥10-≥20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 μg (400-800 international units). Most populations fail to meet these recommended dietary vitamin D requirements. In Europe, 25(OH)D concentrations ,30 nmol/L (12 ng/mL) and ,50 nmol/L (20 ng/mL) are present in ...

Until she was 11 months old, Aleanie Remy-Marquez could have starred in an advertisement for breast milk. She took to nursing easily, was breast-fed exclusively for six or seven months, and ate little else even after that. She was alert and precocious and developed at astonishing speed, her mother said, sitting at four months and walking by eight months.. But once Aleanie started putting weight on her feet, her mother noticed that her legs were curving in a bow shape below the knees. Doctors diagnosed vitamin D-deficiency rickets, a softening of the bones that develops when children do not get enough vitamin D - a crucial ingredient for absorbing calcium and building bone, and the one critical hormone that breast milk often cannot provide enough of.. I thought I was doing the best thing for her, said Stephanie Remy-Marquez, of Hyde Park, Mass., after blood tests showed her daughter had no detectable vitamin D. X-ray images of the babys wrists and knees showed the edges of the bones and growth ...

Objective: Vitamin D deficiency (serum 25-hydroxyvitamin D˂25nmol/L) is extremely common in western-dwelling South Asians but evidence regarding vitamin D supplement usage in this group is very limited. This work identifies demographic, dietary and lifestyle predictors associated with vitamin D supplement use.. Design: Cross-sectional analysis of baseline vitamin D supplement use data.. Setting: UK Biobank cohort.. Subjects: In total, n 8024 South Asians (Bangladeshi, Indian, Pakistani), aged 40-69 years.. Results: Twenty-three % of men and 39% of women (P˂0.001) [22% of Bangladeshis, 32% of Indians, 25% of Pakistanis (P˂0.001)] took a vitamin D containing supplement. Median vitamin D intakes from diet were low at 1.0-3.0 micrograms per day, being highest in Bangladeshis and lowest in Indians (P˂0.001). Logistic regression modelling showed that females had a higher odds of vitamin D supplement use than males (odds ratio (OR) = 2.02; 95% confidence interval (CI) 1.79 to 2.28). A lower ...

The recommended daily intake ranges from 400 international units (IU) a day to 800, depending on age (see Recommended vitamin D intake). However, many people-including health care professionals-often take even higher doses of vitamin D in supplement form as a hedge against chronic disease, despite clear evidence of a benefit.. Were at a crossroads with vitamin D research because we really dont yet know if theres a cause and effect relationship between vitamin D status and outcomes such as heart disease and cancer, says Dr. JoAnn Manson, a professor of medicine at Harvard Medical School and chief of the division of preventive medicine at Brigham and Womens Hospital.. Low vitamin D levels might just be a marker for poor health, Dr. Manson explains. If youre in poor health, youre not outdoors walking, biking, or doing other exercise, she says. Staying indoors more means you dont get the sun exposure to make vitamin D. In addition, people who are obese tend to have low vitamin D levels. ...

Vitamin D deficiency initiates a loss of combat effectiveness by impairing physical and cognitive functioning of combat Operators. Synthesized in response to sunlight and consumed in the diet, vitamin D functions as a hormone and regulates gene expression for nearly 300 genes throughout the human body. These target genes are involved processes essential to combat operations, such as immune function, response to stress, inflammation, and regulation of calcium movement. Since widespread vitamin D deficiency is observed across the U.S. population, poor vitamin D status is expected in Servicemembers. Physical conditions linked to vitamin D deficiency include increased risk for muscle or bone injury, muscle weakness, and reduced neuromuscular function. Hormonally, vitamin D levels have been positively correlated with testosterone levels. Vitamin D deficiency is also associated with cognitive decline, depression, and may prolong recovery following mild traumatic brain injury (mTBI). Since vitamin D ...

Vitamin D is produced in the body via sunlight. It is also obtained from foods such as oily fish (salmon, mackerel, sardines), fortified milk, cereals, and from supplements. Low vitamin D levels may be caused by a lack of sun exposure, lack of dietary vitamin D, malabsorption, side effects from medications or supplements, chronic diseases such as kidney or liver disease, and other causes. In addition, seniors, infants and toddlers, dark-skinned people, and pregnant or breastfeeding women may be particularly at risk for low vitamin D levels. Now, we are discovering there are other factors that may affect vitamin D levels. The new study explored the importance of skin pigmentation, total cholesterol, and baseline blood levels of vitamin D (measured as 25- hydroxy vitamin D) on vitamin D production after ultraviolet B (UVB) exposure. Participants in this study had four UVB exposures several days apart to the chest and back, and each exposure was equivalent to about 30 minutes of sun exposure in the ...

Our yellow sun is the most abundant natural source of Vitamin D available to us, on the planet Earth. Sure, we can get some from consuming organic foods (fatty fish, egg yolks)-and from vitamin enriched foods (like milk) as well as nutritional supplements-but if you want to get more vitamin D all you have to do is go outside and do a little sunbathing.. In a healthy way of course.. But most people dont get enough sunshine. To be honest, most people probably dont get enough fresh air, in general. And that is too bad because recent medical studies suggest that a lack of vitamin D could be linked with both a higher risk for asthma as well as a higher risk for bladder cancer.. Of course, various studies have also linked vitamin D deficiency with other health problems, too. This includes everything from cardiovascular disease to autoimmune disorders to cognitive impairment.. But the latest study-from researchers at the University of Warwick and the University Hospital Coventry and Warwickshire has ...

Supplementation of the diet with vitamins is a common occurrence and there is debate over whether increased vitamin A intake might promote skeletal fragility. Some studies have suggested that increased vitamin A intake may decrease BMD and promote hip fracture; however, other studies have not shown increased bone loss or increased fracture risk, and in some instances, protection from bone loss by vitamin A has been suggested. Vitamin D plays a major role in calcium absorption and mineral homeostasis. Vitamin D deficiency is common and some studies have suggested that he risk of osteoporosis and fracture may increase when increased vitamin A intake occurs in individuals with low vitamin D levels. It is possible that an increased risk of osteoporosis and fracture might exist for increased vitamin A intake and/or increased intake in the face of low vitamin D, but it appears that additional in vivo animal studies and studies in humans to confirm or dispel these possibilities will be necessary before ...

Falls in the elderly, as well as fall-related adverse outcomes such as low trauma bone fractures, are events that could be prevented. Epidemiological studies conducted over the past 15 years provide an increasing number of arguments in favor of an action of vitamin D on muscles and CNS. Vitamin D improves postural balance, propulsion and also executive functions and navigation abilities among older adults. Vitamin D supplementation thus not only determines gait performance, but also prevents the occurrence of falls and their complications among older adults. Mixed data regarding the absence of effect of vitamin D and calcium supplementation are mainly due to the fact that some confounders were not taken into account, but also to the baseline serum vitamin D concentration on initiation of treatment, as a low serum vitamin D concentration appears to be associated with better efficacy. The prescription of at least 800 IU of vitamin D daily in insufficient elderly subjects is a simple intervention ...

Vitamin D and Brain Function. Over the years, we have been instructed to stay out of the sun and if we do venture outside to slap on the sunscreen. But, in truth, these toxic chemical lotions block out the healing benefits of sunlight and promote many brain disorders. Scientists have proven that low levels of vitamin d increase your risk for cancer, osteoporosis and learning disorders like autism. In the past, we obtained 90% of our vitamin D from the sun. For someone with normal vitamin D

Fortunately, vitamin D supplements are commonly and inexpensively available in two forms. Vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) are the two commonly available types. Vitamin D2 is derived from plant and fungal sources and not produced by the human body. Vitamin D3 is produced by the human body, especially as a result of UV sun exposure.. The vitamin D3 form is about 6 times more potent in the human body as the D2 form and not much different in price, so supplementation with D3 seems preferable. The US RDA for Vitamin D is 200 IU per day for children and 400 IU per day for adults. Based upon many recent studies, it is believed that not only is that intake not reached in many people, but that there are reasons to believe the RDA should doubled or more. Considering the low cost of Vitamin D3 supplements and difficulty in reaching toxic levels of vitamin D in the blood even with occasional massive doses such as 100,000 IU, experts are now recommending ongoing long-term vitamin ...

Other studies, however, posted no significant change on bone mineral density upon taking vitamin D supplements, researchers highlighted.. Most healthy adults do not need vitamin D supplements studys lead researcher, Professor Ian Reid from the University of Aucklands Bone Research Group said. Our data suggest that the targeting of low-dose vitamin D supplements only to individuals who are likely to be deficient could free up substantial resources that could be better used elsewhere in health care, the researchers wrote in an article published online October 11 in the Lancet.. This systematic review provides very little evidence of an overall benefit of vitamin D supplementation on bone density. Continuing widespread use of vitamin D for osteoporosis prevention in community-dwelling adults without specific risk factors for vitamin D deficiency seems inappropriate, he added.. The researchers recommend that such supplements should be prescribed only to people who have very low levels of ...

Abstract: Vitamin D clearance is an important and often overlooked aspect of vitamin D biology that has relevant implications for the clinical assessment and treatment of vitamin D deficiency. The circulating concentration of 25-hydroxyvitamin D [25(OH)D] is the most widely accepted measure of vitamin D status, and vitamin D supplements are often prescribed and titrated based on 25(OH)D concentration. However, circulating concentrations of 25(OH)D are necessarily determined by both 25(OH)D production and 25(OH)D clearance. Therefore, 25(OH)D clearance likely plays an important role in the assessment of vitamin D status and the response to vitamin D supplementation. Our preliminary data suggest that the serum concentration of 24,25- dihydroxyvitamin D3 [24,25(OH)2D3] may be a useful biomarker of 25(OH)D clearance that reflects tissue-level vitamin D activity and helps guide vitamin D assessment and treatment. Our parent study, funded by R01DK099199, aims to define 25(OH)D clearance in the ...