TY - JOUR. T1 - Serum vitamin D concentrations and unexplained elevation in ALT among US adults. AU - Liangpunsakul, Suthat. AU - Chalasani, Naga. PY - 2011/7. Y1 - 2011/7. N2 - Background: Low serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT. Methods: A total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels. Results: Participants with unexplained elevation in ALT had significantly lower serum ...
TY - JOUR. T1 - Effect of Vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults. T2 - A randomized placebo-controlled trial. AU - Mousa, Aya. AU - Naderpoor, Negar. AU - Johnson, Josphin. AU - Sourris, Karly. AU - De Courten, Maximilian P.J.. AU - Wilson, Kirsty. AU - Scragg, Robert. AU - Plebanski, Magdalena. AU - De Courten, Barbora. PY - 2017/12/1. Y1 - 2017/12/1. N2 - In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFκB) activity. Yet, no trials have examined the effects of vitamin D supplementation on NFκB activity in-vivo in humans. We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NFκB activity in peripheral blood mononuclear cells (PBMCs). Sixty-five overweight/obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH)D] ≤ 50 nmol/L) adults were randomized to a single 100,000 IU bolus followed by 4,000 IU daily ...
Background: Hydroxymethylglutaryl‑coenzyme A reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. The purpose of this study was to determine the effect of simvastatin on serum Vitamin D status in dyslipidemic patients as Vitamin D status has an impact on monocyte/macrophage function and may also contribute to cardiovascular risk. Methods: Selected individuals (n = 102) were treated with simvastatin (40 mg/day), or matching placebo in a randomized, double‑blind, placebo‑controlled, crossover trial. Each treatment period (with simvastatin or placebo) lasted for 30 days and was separated by a 2‑week washout phase. Serum Vitamin D concentration was assessed pre‑ and post‑treatment. Results: Seventy‑seven completed the trial, noncompliance with the study protocol and drug intolerance or relocation were the causes for drop‑out. No significant ...
INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between ...
Vitamin D is a fundamentally important hormone involved in calcium absorption, bone mineralization and parathyroid hormone production. Vitamin D deficiency may result in a myriad of diseases, such as osteomalacia, rickets and has more recently been identified as a risk factor for diabetes. Accurate determination of serum vitamin D levels is, therefore, paramount when assessing an individual for related pathologies against an appropriate reference range for interpretation. The purpose of this study was to assess vitamin D status between healthy Caucasian and healthy Asian populations of Peterborough, taking into account seasonal serum vitamin D variation. In addition, we evaluated whether a reference range for serum vitamin D of the local population should be race and/or seasonal specific. Using a Chromsystems high-pressure liquid chromatography vitamin D2/D3 methodology upon Agilent 1100 hardware, serum vitamin D status was assessed in 200 subjects of varying age, gender and ethnicity using ...
BACKGROUND:Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. METHODS AND RESULTS:We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least 4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level meta-analysis was performed using random-effects models; individual participant meta-analyses used a 2-stage
TY - JOUR. T1 - Effect of Vitamin D Supplementation on Markers of Vascular Function. T2 - A Systematic Review and Individual Participant Meta-Analysis. AU - Beveridge, Louise A.. AU - Khan, Faisel. AU - Struthers, Allan D.. AU - Armitage, Jane. AU - Barchetta, Ilaria. AU - Bressendorff, Iain. AU - Cavallo, Maria Gisella. AU - Clarke, Robert. AU - Dalan, Rinkoo. AU - Dreyer, Gavin. AU - Gepner, Adam D.. AU - Forouhi, Nita G.. AU - Harris, Ryan A.. AU - Hitman, Graham A.. AU - Larsen, Thomas. AU - Khadgawat, Rajesh. AU - Marckmann, Peter. AU - Mose, Frank H.. AU - Pilz, Stefan. AU - Scholze, Alexandra. AU - Shargorodsky, Marina. AU - Sokol, Seth I.. AU - Stricker, Hans. AU - Zoccali, Carmine. AU - Witham, Miles D.. PY - 2018/5/30. Y1 - 2018/5/30. N2 - Background Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is ...
A recent study has found a further link between low vitamin D levels and premenopausal breast cancer.The study, by researchers from the University of California, San Diego School of Medicine, examined 1,200 healthy women and found that those whose serum vitamin D levels were low during the three-month period just before diagnosis had approximately three times the risk of breast cancer as women in the highest vitamin D group. Several previous studies have shown that low serum levels of vitamin D are associated with a higher risk of premenopausal breast cancer.
TY - JOUR. T1 - Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. AU - Mahon, B. D.. AU - Gordon, S. A.. AU - Cruz, J.. AU - Cosman, F.. AU - Cantorna, M. T.. PY - 2003/1/1. Y1 - 2003/1/1. N2 - Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17±6 ng/ml at baseline to 28±8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-β1 levels from 230±21 pg/ml at baseline to 295±40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-β1 levels. Tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not ...
Vitamin D can be made in the skin by exposure to sunlight and can be found in certain foods. Vitamin D levels are alarmingly low in many North American children. Several health issues have been linked with low vitamin D. These include colds caused by viruses and asthma attacks. However, no study has determined whether vitamin D supplementation can reduce the risk of these conditions in young children where they are most common and most severe.. The goals of this study are to determine whether wintertime high dose vitamin D supplementation of preschoolers can prevent colds and asthma attacks. The investigators also aim to work out how much money would be saved by the health care system and society if preschoolers were routinely supplemented with Vitamin D during the winter. The investigators believe that preschoolers receiving high dose vitamin D supplementation during the wintertime will be less likely to have colds, asthma attacks, and low vitamin D levels and will be less likely to use the ...
Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses. Controversy continues on the relative potency of vitamin D2 compared to D3 and of daily compared to weekly or monthly doses, in increasing/maintaining total 25 OH vitamin D level.. The investigators plan to conduct a controlled trial to compare the effect of various vitamin D supplements on 25 OH vitamin D levels in healthy adults with starting 25 OH vitamin D level between 20 to 50 nmol/L. ...
The present study used a systematic review approach to identify relevant randomised control trials (RCT) with vitamin D and then apply meta-regression to explore the most appropriate model of the vitamin D intake-serum 25-hydroxyvitamin D (25(OH)D) relationship to underpin setting reference intake values. Methods included an updated structured search on Ovid MEDLINE; rigorous inclusion/exclusion criteria; data extraction; and meta-regression (using different model constructs). In particular, priority was given to data from winter-based RCT performed at latitudes ,49•58°N (n 12). A combined weighted linear model meta-regression analyses of natural log (Ln) total vitamin D intake (i.e. diet and supplemental vitamin D) versus achieved serum 25(OH)D in winter (that used by the North American Dietary Reference Intake Committee) produced a curvilinear relationship (mean (95% lower CI) serum 25(OH)D (nmol/l) = 9•2 (8•5) Ln (total vitamin D)). Use of non-transformed total vitamin D intake data ...
Falls in the elderly, as well as fall-related adverse outcomes such as low trauma bone fractures, are events that could be prevented. Epidemiological studies conducted over the past 15 years provide an increasing number of arguments in favor of an action of vitamin D on muscles and CNS. Vitamin D improves postural balance, propulsion and also executive functions and navigation abilities among older adults. Vitamin D supplementation thus not only determines gait performance, but also prevents the occurrence of falls and their complications among older adults. Mixed data regarding the absence of effect of vitamin D and calcium supplementation are mainly due to the fact that some confounders were not taken into account, but also to the baseline serum vitamin D concentration on initiation of treatment, as a low serum vitamin D concentration appears to be associated with better efficacy. The prescription of at least 800 IU of vitamin D daily in insufficient elderly subjects is a simple intervention ...
BACKGROUND: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with ... read more vitamin D insufficiency/deficiency. METHODS: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (,50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D ,50 nmol/l) was reached in ,75% without side effects nor reaching toxic levels. RESULTS: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency ...
Results We studied 117 Participants, 62 females and 55 males, age was 71 (5) years, of who 61 received 3,750 IU of vitamin D, and 55 received 600 IU/day. Vitamin D receptor genetic polymorphisms distribution was comparable in both arms. Daily vitamin D intake excluding provided supplements was 7.59 (1.21) mcg and 8.53 (1.36) mcg from the 24 h recall, and food frequency questionnaires, respectively (p was NS between the two arms). Calories, calcium, protein, carbohydrate and fat mean intake was also similar across both arms. The high-dose group achieved significantly higher 25OH-vitamin D serum levels at twelve months 34.9 (9.3) ng/ml compared to low-dose, 21.9 (6.1) ng/ml (p,0.0001). Difference between arms remained significant adjusting for gender, baseline BMI, Fok, Bsml and Taq genetic polymorphism, baseline serum vitamin D and dietary intake of vitamin D, calcium, calories, proteins, carbohydrates and fats. None of these dietary intake measures was found to have significant contribution to ...
In this study, data were available with 451 kidney stone cases and 482 controls for the analysis. This work provided convincing evidence that serum vitamin D level in kidney stone patients was significantly higher than that in non-kidney stone controls. The associations were also significant both in Europe and in Asia populations.. In our study, significant between-study heterogeneity was found between serum vitamin D levels and kidney stone risk. Previous paper [21] had reported that heterogeneity is common in the meta-analyses. To explore the potential sources of between-study heterogeneity is therefore an essential component of meta-analysis. The high degree of heterogeneity might have arisen from publication year, study design and geographic locations. Therefore, we used meta-regression to explore the causes of heterogeneity by covariates. However, no covariate had significant impact on the high between-study heterogeneity among those mentioned above. Considering the pooled meta-analysis was ...
This study was designed to assess the beneficial effects of high-dose (cholecalciferol) vitamin D supplementation on metabolic profiles and pregnancy outcomes among pregnant women at risk for pre-eclampsia. This randomized double-blind placebo-controlled clinical trial was performed among 60 pregnant women at risk for pre-eclampsia according to abnormal uterine artery Doppler waveform. Subjects were randomly divided into 2 groups to receive 50-000 IU vitamin D supplements (n=30) or receive placebo (n=30) every 2 weeks from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline study and 12 weeks after the intervention to quantify relevant variables. Newborns anthropometric measurements were determined. Pregnant women who received cholecalciferol supplements had significantly increased serum 25-hydroxyvitamin D concentrations (+17.92±2.28 vs. +0.27±3.19-ng/ml, p,0.001) compared with the placebo. The administration of cholecalciferol supplements, compared with the ...
Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)-we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D₃ (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March⁻May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D₃ group and decreased by 11 nmol/L in
Background and Objective: Low Vitamin D levels have been implicated as contributing to statin myalgia, but studies on the relationship between Vitamin D and statin-associated muscle side effects (SAMS) have produced discrepant results. We examined the influence of baseline and change in Vitamin D levels in patients with self-reported statin myalgia who developed muscle symptoms during a statin-placebo cross-over trial.. Methods: Statin myalgia was verified in 120 patients with prior statin muscle complaints using an 8-week randomized, double-blind crossover trial of simvastatin (SIMVA) 20 mg/d and placebo. Anthropometrics, medical histories, demographics and serologic data (including 25 (OH)Vitamin D) were measured at each phase of the trial.. Results: Forty three (35.8%) patients met the study criteria for myalgia, experiencing muscle pain on SIMVA but not placebo. Serum Vitamin D levels (mean ± standard deviation) prior to simvastatin treatment were not different between patients who did ...
Combining results from 12 studies of vitamin D intake and 7 studies of circulating 25(OH)D, high compared with low dietary vitamin D intake was associated with an 11% marginally decreased risk of colorectal adenomas and high versus low circulating 25(OH)D with a statistically significant 30% decreased risk.. The inverse association with colorectal adenomas was similar for dietary intake compared with total vitamin D intake (OR, 0.90 versus 0.89), whereas no association with supplemental vitamin D intake was found (OR, 1.0). That total intake did not have a stronger association compared with dietary sources alone was unexpected given that dietary sources of vitamin D are uncommon, and in some populations, supplements are an important source of total vitamin D intake. Furthermore, supplemental sources of vitamin D may contain folate and other micronutrients that could enhance an inverse relation between supplemental vitamin D and adenomas (36, 37).. The lack of association with supplemental ...
What is the optimal vitamin D level?. As already mentioned, different sources recommend different vitamin D levels - currently there is no clear opinion. Official bodies, such as the German Nutrition Society, recommend a vitamin D level of 20 ng/ml. While the Institute of Medicine considers a level of 20 ng/ml to be sufficient, the minimum vitamin D level recommended by the Vitamin D Council is 40 ng/ml. The Grassroots Health initiative recommends a level of 40-60 ng/ml. Dr. Raimund von Helden is convinced that an optimal vitamin D level is between 50-90 ng/ml.. It can now be assumed that the average value should be around 30 - 80 ng/ml. However, the optimal value for a vitamin D level is above 50 ng/ml in almost all studies.. The vitamin d rapid self-test from kiweno interprets vitamin D values as follows:. 0-10 ng/ml - severe deficiency. 11-30 ng/ml - deficiency. 31-100 ng/ml - optimal supply. , 100 ng/ml - Overdose. Vitamin D filling up and maintenance. In the case of a severe deficiency, we ...
Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial-a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offsprings bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Womens Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks gestation [r = -0.16, 95% confidence interval (CI) -0
Other studies, however, posted no significant change on bone mineral density upon taking vitamin D supplements, researchers highlighted.. Most healthy adults do not need vitamin D supplements studys lead researcher, Professor Ian Reid from the University of Aucklands Bone Research Group said. Our data suggest that the targeting of low-dose vitamin D supplements only to individuals who are likely to be deficient could free up substantial resources that could be better used elsewhere in health care, the researchers wrote in an article published online October 11 in the Lancet.. This systematic review provides very little evidence of an overall benefit of vitamin D supplementation on bone density. Continuing widespread use of vitamin D for osteoporosis prevention in community-dwelling adults without specific risk factors for vitamin D deficiency seems inappropriate, he added.. The researchers recommend that such supplements should be prescribed only to people who have very low levels of ...
Vitamin D deficiency is a global epidemic and has been linked to chronic diseases, with research finding a higher prevalence of these diseases in those who are deficient in vitamin D. Previous research has also shown that vitamin D supplementation helps reduce the risk of influenza. Viral infections often occur in the winter when vitamin D levels are the lowest and supplementation is often required in order to reach normal concentrations.. In a review published two weeks ago in Nutrients, researchers investigated vitamin Ds potential effect in helping to reduce the risk of respiratory tract infections. According to this review, a vitamin D deficiency has been associated with an increased risk of acute respiratory distress syndrome as well as chronic disease. An observational study in Connecticut which included 198 healthy adults in the fall and winter of 2009 through 2010 demonstrated a reduced risk of acute respiratory tract infections in those with a vitamin D insufficiency. Only 17% of ...
BACKGROUND: Reports on the dose response to vitamin D are conflicting, and most data were derived from white men and women.. OBJECTIVE: The objective was to determine the response of serum 25-hydroxyvitamin D [25(OH)D] to oral vitamin D(3) supplementation in an African American population.. DESIGN: Healthy black postmenopausal women (n = 208) participated in a vitamin D(3) supplementation trial for a period of 3 y. Analyses were done in the vitamin D supplementation arm (n = 104) to quantify the response in serum 25-hydroxyvitamin D concentrations at a steady state vitamin D input. The participants received 20 microg/d (800 IU) oral vitamin D(3) for the initial 2 y and 50 microg/d (2000 IU) for the third year.. RESULTS: Supplementation with 20 microg/d (800 IU/d) vitamin D(3) raised the mean serum 25(OH)D concentration from a baseline of 46.9 +/- 20.6 nmol/L to 71.4 +/- 21.5 nmol/L at 3 mo. The mean (+/-SD) concentration of serum 25(OH)D was 87.3 +/- 27.0 nmol/L 3 mo after supplementation ...
Vitamin D is called the sunshine vitamin - because we can usually get it from the suns ultraviolet rays; it supports bone development and is needed for calcium and vitamin C absorption, and it supports the nervous system. Vitamin D plays a dual role as both a vitamin and a hormone that stimulates the body to absorb calcium. Natural Factors Vitamin D3 is derived from sheep wool lanolin.Vitamin D3 (cholecalciferol from animal sources). Vitamin D3 is the form found in fish oils and eggs, and is produced by sunlight on human skin. Natural Factors Vitamin D3 is derived from sheep wool lanolin. Vitamin D plays a dual role as both a vitamin and a hormone that stimulates the body to absorb calcium. Vitamin D, calcium, and phosphorus are needed to keep bones strong. Without vitamin D even a diet adequate in calcium will not help because the body needs vitamin D to absorb calcium. People with low vitamin D levels tend to have soft, thin bones, predisposing them to fractures, especially hip
Objective: Vitamin D deficiency (serum 25-hydroxyvitamin D˂25nmol/L) is extremely common in western-dwelling South Asians but evidence regarding vitamin D supplement usage in this group is very limited. This work identifies demographic, dietary and lifestyle predictors associated with vitamin D supplement use.. Design: Cross-sectional analysis of baseline vitamin D supplement use data.. Setting: UK Biobank cohort.. Subjects: In total, n 8024 South Asians (Bangladeshi, Indian, Pakistani), aged 40-69 years.. Results: Twenty-three % of men and 39% of women (P˂0.001) [22% of Bangladeshis, 32% of Indians, 25% of Pakistanis (P˂0.001)] took a vitamin D containing supplement. Median vitamin D intakes from diet were low at 1.0-3.0 micrograms per day, being highest in Bangladeshis and lowest in Indians (P˂0.001). Logistic regression modelling showed that females had a higher odds of vitamin D supplement use than males (odds ratio (OR) = 2.02; 95% confidence interval (CI) 1.79 to 2.28). A lower ...
What Is It?. Vitamin D 3 enhances calcium absorption and retention, a key nutritional role in supporting healthy bones, and may play a potential role in cardiovascular, colon and cellular health. Vitamin D levels have been shown to decline with age, due primarily to a reduction in either absorption or metabolism by the liver. Decreased exposure to sunlight, a vegetarian diet, or a low intake of vitamin D fortified foods also play a role in inadequate vitamin D levels.*. Uses For Vitamin D 3. Bone Health: Vitamin D promotes intestinal calcium and phosphorous absorption and reduces urinary calcium loss, essential mechanisms for maintaining proper calcium levels in the body and for healthy bone composition. Clinical studies involving vitamin D supplementation suggest the importance of vitamin D in addition to calcium for bone health. Vitamin D supplementation alone may also support bone health.*. Cardiovascular Support: Vitamin D may also provide cardiovascular support for some individuals, which ...
What Is It?. Vitamin D 3 enhances calcium absorption and retention, a key nutritional role in supporting healthy bones, and may play a potential role in cardiovascular, colon and cellular health. Vitamin D levels have been shown to decline with age, due primarily to a reduction in either absorption or metabolism by the liver. Decreased exposure to sunlight, a vegetarian diet, or a low intake of vitamin D fortified foods also play a role in inadequate vitamin D levels.*. Uses For Vitamin D 3. Bone Health: Vitamin D promotes intestinal calcium and phosphorous absorption and reduces urinary calcium loss, essential mechanisms for maintaining proper calcium levels in the body and for healthy bone composition. Clinical studies involving vitamin D supplementation suggest the importance of vitamin D in addition to calcium for bone health. Vitamin D supplementation alone may also support bone health.*. Cardiovascular Support: Vitamin D may also provide cardiovascular support for some individuals, which ...
Jarrow Formulas Vitamin D3 2500IU 100 Softgels Vitamin D3 Promotes Calcium and Bone Metabolism Immune Function Vitamin D3 WHAT DOES VITAMIN D3 DO? Jarrow FORMULAS Vitamin D3 provides cholecalciferol, the most bioavailable form of vitamin D. Vitamin D3 is converted by the kidneys into the hormone calcitriol, the active form of vitamin D3. Vitamin D3 enhances calcium and phosphorous absorption, stimulates the synthesis of osteocalcin (an important structural protein in bone), and is involved in proper cell differentiation and immune response. Keep out of the reach of children. Suggested Usage For adults, take 1 softgel every other day with a meal or as directed by your qualified health care consultant. NOTE: Individuals consuming more than 2,000 IU/day of vitamin D should periodically obtain a serum 25-hydroxy vitamin D measurement. If you have a medical condition (especially kidney stones or dysfunction, hyperparathyroidism,
Abstract: Vitamin D clearance is an important and often overlooked aspect of vitamin D biology that has relevant implications for the clinical assessment and treatment of vitamin D deficiency. The circulating concentration of 25-hydroxyvitamin D [25(OH)D] is the most widely accepted measure of vitamin D status, and vitamin D supplements are often prescribed and titrated based on 25(OH)D concentration. However, circulating concentrations of 25(OH)D are necessarily determined by both 25(OH)D production and 25(OH)D clearance. Therefore, 25(OH)D clearance likely plays an important role in the assessment of vitamin D status and the response to vitamin D supplementation. Our preliminary data suggest that the serum concentration of 24,25- dihydroxyvitamin D3 [24,25(OH)2D3] may be a useful biomarker of 25(OH)D clearance that reflects tissue-level vitamin D activity and helps guide vitamin D assessment and treatment. Our parent study, funded by R01DK099199, aims to define 25(OH)D clearance in the ...
Low bone mineral density has been identified as a risk factor for osteoporotic fracture1 and fracture in childhood.2 Vitamin D supplementation in childhood may be a clinical strategy to maximise peak bone mass in children and, in turn, improve bone mineral density and reduce fracture risk in adulthood. However, the effectiveness of vitamin D supplementation for improving bone density in children is unclear. Therefore, Winzenberg and colleagues performed a systematic review and meta-analysis to evaluate the efficacy of vitamin D supplementation for improving paediatric bone mineral density, including how supplement dose and baseline vitamin D status may impact the outcome.. ...
Effects of low vitamin D level On Body - Vitamin D is crucial for strong and healthy bone and also the teeth. Lacking the recommended amounts in...
Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from ≥25 to ≥50 nmol/L (≥10-≥20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 μg (400-800 international units). Most populations fail to meet these recommended dietary vitamin D requirements. In Europe, 25(OH)D concentrations ,30 nmol/L (12 ng/mL) and ,50 nmol/L (20 ng/mL) are present in ...
TY - JOUR. T1 - Does vitamin D protect against DNA damage?. AU - Nair-Shalliker, Visalini. AU - Armstrong, Bruce K.. AU - Fenech, Michael. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Vitamin D is a secosteroid best known for its role in maintaining bone and muscle health. Adequate levels of vitamin D may also be beneficial in maintaining DNA integrity. This role of vitamin D can be divided into a primary function that prevents damage from DNA and a secondary function that regulates the growth rate of cells. The potential for vitamin D to reduce oxidative damage to DNA in a human has been suggested by clinical trial where vitamin D supplementation reduced 8-hydroxy-2-deoxyguanosine, a marker of oxidative damage, in colorectal epithelial crypt cells. Studies in animal models and in different cell types have also shown marked reduction in oxidative stress damage and chromosomal aberrations, prevention of telomere shortening and inhibition of telomerase activity following treatment with vitamin D. The ...
Supplementation of the diet with vitamins is a common occurrence and there is debate over whether increased vitamin A intake might promote skeletal fragility. Some studies have suggested that increased vitamin A intake may decrease BMD and promote hip fracture; however, other studies have not shown increased bone loss or increased fracture risk, and in some instances, protection from bone loss by vitamin A has been suggested. Vitamin D plays a major role in calcium absorption and mineral homeostasis. Vitamin D deficiency is common and some studies have suggested that he risk of osteoporosis and fracture may increase when increased vitamin A intake occurs in individuals with low vitamin D levels. It is possible that an increased risk of osteoporosis and fracture might exist for increased vitamin A intake and/or increased intake in the face of low vitamin D, but it appears that additional in vivo animal studies and studies in humans to confirm or dispel these possibilities will be necessary before ...
Vitamin D is actually a hormone, and along with thyroid hormone, is one of the two hormones every cell in your body needs. It regulates hundreds of different pathways throughout the body.. Bone density. Vitamin D has long been known to play a role in preventing breakdown of bones and increasing the strength of the skeletal system.. Mood regulation. Low vitamin D is linked to a 14 percent increase depression and a 50 percent increase in suicide rates. Increasing vitamin D intake can help improve anxiety and depression.. Brain health. Vitamin Ds biologically active form has shown neuroprotective effects including the clearance of amyloid plaques common to Alzheimers Disease. Associations have also been noted between low 25-hydroxyvitamin D and dementia.. Reduced cancer risk. Optimal vitamin D levels are associated with lower rates of cancers of the breast, ovaries, prostate, and pancreas.. Sleep quality. Adequate vitamin D is associated with improved sleep.. Immune regulation. Vitamin D plays a ...
Several factors, including regional UVB levels, vitamin D intake, skin pigmentation, sunlight exposure behaviors, and adiposity may influence in vivo vitamin D levels (21). Seasonal variation in 25(OH)D concentrations have been observed for residents in Boston (10-13), with inadequate vitamin D intake and winter season being independent predictors of hypovitaminosis D (13). We investigated the effects of season and vitamin D intake on NSCLC survival and found that both higher UVB exposure (patients who had surgery in summer) and higher vitamin D intake (diet and supplement) improved lung cancer survival. Patients who had surgery in summer with high vitamin D intake had a 3-fold better RFS and a 4-fold better OS than those with surgery in winter and low vitamin D intake, with all of the other patient groups falling between the two groups (Table 4; Fig. 2). In Cox proportional hazards models, we adjusted for the most important predictors of NSCLC prognosis, including age, gender, smoking status, ...
BACKGROUND People with intellectual disability (ID) are thought to be at an increased risk of fractures. The extent of this increase in risk has been incompletely documented in the literature, and the underlying reasons remain to be elucidated. METHODS The aims of our study were to document the vitamin D status and fracture incidence in an intellectually disabled population, to test for associations between vitamin D status and possible risk factors for reduced vitamin D levels, and to determine the efficacy of oral vitamin D supplementation in restoring appropriate vitamin D levels in those found to be vitamin D insufficient. A 5-year retrospective audit of fractures in 337 individuals with ID receiving health care at a residential facility was performed. Data analysed included age, gender, mobility, dietary status, incident fractures, medications and 25-hydroxyvitamin D levels. Vitamin D insufficient individuals received oral vitamin D supplementation, and had repeat testing to assess treatment
The mean of serum 25(OH)D3 level was 22.80 ± 16,23 ng/mL.14 patients (25.5%) had vitamin D deficiency (,10 ng/mL), 34 patients (61.8%) had vitamin D insufficiency (10-30 ng/mL), and 7 patients (14.7%) had normal vitamin D levels. There were significant difference level of anti-dsDNA antibodies (112.46 vs 267.13 U/ml; p , 0.05) and IgM ACA (16.40 vs 29.7 IU/ml; p , 0,05) in patients with vitamin D insufficiency and vitamin D defisiency. Serum level of 25(OH)D3 were negatively related with level of anti-dsDNA and IgM ACA (r: - 0, and r: - 0,72 respectively). The mean of SLEDAI was 15,0 + 10.46. Serum vitamin D levels were inversely correlated with SLEDAI (R=-0.319, p,0.05). Normal BMD at lumbal spine found in 21 (38.2%) patients. 26 patients (47.3%) were osteopenia, and 8 (14.5%) patients were osteoporosis. At femoral neck, 25 (45.5%) patients had normal BMD, 23(41.8%) patients were osteopenia, 7 (12.7%) patients were osteoporosis. There were no significant correlation between vitamin D level and ...
Vitamin D and Brain Function. Over the years, we have been instructed to stay out of the sun and if we do venture outside to slap on the sunscreen. But, in truth, these toxic chemical lotions block out the healing benefits of sunlight and promote many brain disorders. Scientists have proven that low levels of vitamin d increase your risk for cancer, osteoporosis and learning disorders like autism. In the past, we obtained 90% of our vitamin D from the sun. For someone with normal vitamin D
The recommended daily intake ranges from 400 international units (IU) a day to 800, depending on age (see Recommended vitamin D intake). However, many people-including health care professionals-often take even higher doses of vitamin D in supplement form as a hedge against chronic disease, despite clear evidence of a benefit.. Were at a crossroads with vitamin D research because we really dont yet know if theres a cause and effect relationship between vitamin D status and outcomes such as heart disease and cancer, says Dr. JoAnn Manson, a professor of medicine at Harvard Medical School and chief of the division of preventive medicine at Brigham and Womens Hospital.. Low vitamin D levels might just be a marker for poor health, Dr. Manson explains. If youre in poor health, youre not outdoors walking, biking, or doing other exercise, she says. Staying indoors more means you dont get the sun exposure to make vitamin D. In addition, people who are obese tend to have low vitamin D levels. ...
Vitamin D is produced in the body via sunlight. It is also obtained from foods such as oily fish (salmon, mackerel, sardines), fortified milk, cereals, and from supplements. Low vitamin D levels may be caused by a lack of sun exposure, lack of dietary vitamin D, malabsorption, side effects from medications or supplements, chronic diseases such as kidney or liver disease, and other causes. In addition, seniors, infants and toddlers, dark-skinned people, and pregnant or breastfeeding women may be particularly at risk for low vitamin D levels. Now, we are discovering there are other factors that may affect vitamin D levels. The new study explored the importance of skin pigmentation, total cholesterol, and baseline blood levels of vitamin D (measured as 25- hydroxy vitamin D) on vitamin D production after ultraviolet B (UVB) exposure. Participants in this study had four UVB exposures several days apart to the chest and back, and each exposure was equivalent to about 30 minutes of sun exposure in the ...
Vitamin D improved heart health in dieters, green tea reduced abdominal fat, and calcium helped those with low calcium lose more weight, new findings show. In a study of heart health in dieters, researchers noted that losing excess weight cuts the chances of heart disease, and explained that low vitamin D and high parathyroid hormone levels are two new heart health risk factors. About 200 healthy but overweight men and women with low vitamin D levels took 3,320 IU of vitamin D per day or a placebo. After 12 months, vitamin D levels were normal in the vitamin D group but remained low for placebo. Measuring other risk factors, compared to placebo, the vitamin D group had lost 4.5 times the amount of blood fats (triglycerides), had three times lower levels of an inflammatory sign (tumor necrosis factor-alpha) and lower levels of parathyroid hormone. Doctors in a diet study thought that catechins-the powerful antioxidants in green tea-could help the body burn fat. A group of 132 overweight or obese ...
Summary The aim was to meta-analyze randomized controlled trials of calcium plus vitamin D supplementation and fracture prevention. Meta-analysis showed a significant 15 % reduced risk of total fractures (summary relative risk estimate [SRRE], 0.85; 95 % confidence interval [CI], 0.73-0.98) and a 30 % reduced risk of hip fractures (SRRE, 0.70; 95 % CI, 0.56-0.87). Introduction: Calcium plus vitamin D supplementation has been widely recommended to prevent osteoporosis and subsequent fractures; however, considerable controversy exists regarding the association of such supplementation and fracture risk. The aim was to conduct a meta-analysis of randomized controlled trials [RCTs] of calcium plus vitamin D supplementation and fracture prevention in adults. Methods: A PubMed literature search was conducted for the period from July 1, 2011 through July 31, 2015. RCTs reporting the effect of calcium plus vitamin D supplementation on fracture incidence were selected from English-language studies. ...
Can vitamin D deficiency be the culprit behind increase in weight? To know, how vitamin D insufficiency can contribute to weight gain, read the following article. About Buzzle Privacy Policy. Find Out How Weight Gain And Low Vitamin D Levels Are Related. As we all know, vitamin d deficiency and inability to lose weight number of factors are responsible for weight gain. Too little exercise and indulgence in vitamin d deficiency and inability to lose weight foods are the primary reasons why people become overweight.. However, recent studies does eating cottage cheese before bed help you lose weight that vitamin D levels in the body influence weight. Low vitamin D and weight gain are linked and hence vitamin D deficiency needs to be avoided. Low Vitamin D and Weight Gain. Did you know that low vitamin D levels can put you in the risk zone of excess weight gain. According to recent research, people have higher chances of gaining weight if their blood vitamin D levels are persistently low.. Although, ...
Smokers with low vitamin D concentrations had a higher risk of developing diabetes during their pregnancy than did nonsmokers with adequate vitamin D levels. Both smoking and having low vitamin D levels put women at a greater risk than either risk factor alone. The researchers concluded more investigation is needed to confirm their results and study the interactive effect of smoking and low vitamin D levels.A total of 20 ng/ml (nanograms/milliliter) to 50 ng/ml of vitamin D is considered an average blood level. If the level falls below 12 ng/ml, it is seen as deficient. Vitamin D deficiency could have been what Charles Dickens had in mind when he created Tiny Tim crippled. A deficiency of the vitamin causes rickets in children and osteomalacia in adults: bones can become brittle, thin, or misshapen.. Fortunately, both human skin and mushrooms make vitamin D when exposed to sunlight. So mothers can take in their vitamin D naturally from being outdoors for a few minutes a day without sunscreen, or ...
Long known for its role in bone development, vitamin D has recently been implicated in a wide range of disorders. Emerging evidence suggests that low vitamin D levels may play a role in the development of certain cancers and heart disease and lead to suppressed immunity, the researchers note.. Anemia, which occurs when the body doesnt have enough oxygen-carrying red blood cells, is believed to affect one in five children at some point in their lives, experts say. Several large-scale studies have found severe vitamin D deficiency in about a tenth of U.S. children, while nearly 70 percent have suboptimal levels. If our findings are confirmed through further research, low vitamin D levels may turn out to be a readily modifiable risk factor for anemia that we can easily tackle with supplements, says senior study investigator Jeffrey Fadrowski, M.D., M.H.S., also a pediatric kidney specialist at Johns Hopkins.. The research was funded by the National Institute of Diabetes, Digestive and Kidney ...
BACKGROUND Low 25-hydroxyvitamin D levels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease. OBJECTIVE To investigate the association between low serum vitamin D levels and recurrent spinal cord disease. DESIGN, SETTING, AND PATIENTS We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25-hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord. MAIN OUTCOME MEASURE Levels of 25-hydroxyvitamin D. RESULTS Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race. CONCLUSIONS This study provides a basis for a prospective
Name of the Test : Bioavailable Vitamin D (25 hydroxy). Alias Names : Weakly bound Vitamin D, Albumin bound Vitamin D, Bioactive Vitamin D for mineral metabolism. Bioavailable Vitamin D determination is useful when :. - There is a discrepancy with total vitamin D ( 25 OH ) with calcium & PTH levels(i.e) Renal dialysis patients. - There is discrepancy in Bone mineral density with total Vitamin D ( 25 OH ) concentration. - There is a increased level of Vitamin D binding protein as in pregnancy Clinical applications:. Vitamin D deficiency is determined by measuring circulating 25 hydroxy Vitamin D (25(OH) D).Over 85 % of circulating 25(OH) D is tightly bound to a specific vitamin D binding protein (DBP). A lesser amount is bound loosely with albumin. Less than 1% is free Vitamin D (Free D). DBP levels are high during pregnancy and individuals with estrogen treatment. The free fraction along with the albumin bound fraction, called Bioavailable Vitamin D, is readily available for metabolic ...
Name of the Test: Bioavailable Vitamin D (1, 25 dihydroxy). Alias Names : Weakly bound Vitamin D 1,25 ; Albumin bound Vitamin D 1, 25 dihydroxy(1,25 di OH). Bioavailable Vitamin D determination is useful when:. - There is a discrepancy with total vitamin D ( 25 OH ) with calcium & PTH levels(i.e) Renal dialysis patients. - There is an increased level of Vitamin D binding protein as in pregnancy Clinical applications:. Vitamin D is produced in the skin. Exogenous Vitamin D is absorbed in the intestine and converted to 25 hydroxy vitamin D. 25 hydroxy(OH)vitamin D is converted into bioactive vitamin D (1, 25 dihydroxyl vitamin D) in the kidney .Hence, patients with chronic renal failures results in vitamin D deficiency. Over 85 % of circulating 1, 25 dihydroxy D is tightly bound to a specific vitamin D binding protein (DBP). A lesser amount is bound loosely with albumin. Less than 1% is the free form of Vitamin D 1, 25 dihydroxy. DBP levels are high during pregnancy and individuals with estrogen ...
TY - THES. T1 - Vitamin D deficiency is associated with airway remodelling and altered lung structure and function. AU - Foong, Rachel Ee Lin. PY - 2015. Y1 - 2015. N2 - The prevalence of vitamin D deficiency is high all over the world and there is now a large body of evidence linking vitamin D deficiency to chronic conditions, including autoimmune, infectious, cardiovascular and respiratory disease. Of relevance to chronic respiratory disease, some studies have shown that vitamin D deficiency is more prevalent in patients with asthma. Lower vitamin D levels are also associated with reduced lung function, increased asthma exacerbations and airway remodelling. In asthma, structural alterations in the lung have origins in early life, and factors that influence lung development may alter lung function and cause an increased susceptibility to disease in the long term. Vitamin D may be a factor affecting lung development, and maternal vitamin D deficiency may therefore contribute to asthma ...
Amy Skversky, M.D., M.S.When doctors write that prescription for steroids and theyre sending the patients for lab tests, they should also get the vitamin D level measured, said study lead author Amy Skversky, M.D., M.S., assistant professor of pediatrics at Einstein and Montefiore Medical Center, the University Hospital for Einstein.. The severe vitamin D deficiency assessed in this study (defined as levels below 10 nanograms per milliliter of blood) is known to be associated with osteomalacia (softening of the bones), rickets (softening of bones in children) and clinical myopathy (muscle weakness). While there is much debate on the issue, vitamin D levels between 20 and 50 ng/ml are generally considered adequate for bone and overall health in healthy individuals. Steroids have been shown to cause vitamin D deficiency, possibly by increasing levels of an enzyme that inactivates the vitamin.. Smaller studies involving people often prescribed steroids (i.e., children with asthma and patients ...
A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBPs biological functions in vitamin D metabolism and action. On vitamin D-replete diets, DBP-/-mice had low levels of total serum vitamin D metabolites but were otherwise normal. When maintained on vitamin D-deficient diets for a brief period, the DBP-/- but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency. DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. After an overload of vitamin D, DBP-/- mice were unexpectedly less susceptible to hypercalcemia and its toxic effects. Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/-mice. Thus, the role ...
Vitamin D refers to a group of fat-soluble molecules, from which the most important in humans are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol) [1]. A small amount of these can be obtained from the diet, but about 90% comes from synthesis of vitamin D in the skin when exposed to ultraviolet B radiation from the sun [2, 3]. This dermal synthesis depends on the area of skin exposed to sunlight, duration of exposure, latitude, season and skin type [4, 5]. In Sweden, latitude 55-69° North, there is no dermal synthesis of vitamin D during the winter months [1, 4]. Vitamin D has a significant role in mineralization of bone, skeletal maturation, regulating the concentration of calcium and phosphate, therefore severe vitamin D deficiency can cause osteomalacia in adults and rickets in pediatric population [6]. Vitamin D deficiency is a known risk factor causing fractures, osteoporosis and muscle weakness in elderly [5, 7, 8].. Vitamin D deficiency might be associated with reduced ...
itation: Orsini LGS, Pinheiro MM, Castro CHM, Silva AEB, Szejnfeld VL (2013) Bone Mineral Density Measurements, Bone Markers and Serum Vitamin D Concentrations in Men with Chronic Non-Cirrhotic Untreated Hepatitis C. PLoS ONE 8(11): e81652. doi:10.1371/journal.pone.0081652. Editor: Luc Malaval, INSERM U1059/LBTO, Université Jean Monnet, France. Received: June 10, 2013; Accepted: October 15, 2013; Published: November 28, 2013. Copyright: © 2013 Orsini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.. Funding: This study was funded by a grant from the Rheumatology Division at the Universidade Federal de São Paulo/Escola Paulista de Medicina (Unifesp/EPM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.. Competing interests: The ...
OBJECTIVE: To assess the effect of vitamin D supplementation on enhancement of embryos implantation rates in intracytoplasmic sperm injection procedures. STUDY DESIGN: A randomized double-blinded controlled trial. SETTING: Assisted Reproduction Unit of Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Egypt. DURATION: From December 1st 2017 to the end of October 2018. SUBJECTS and METHDS: Eighty infertile couples that underwent ICSI procedure were entrapped in this study. Patients were divided into two groups; Group I (Vitamin D group) = 40 patients (received vitamin D supplementation in the form of Vidrop oral drops 600 IU/day starting after ovum pickup) and Group II (placebo group) = 40 patients (received a placebo
If sun exposure is insufficient, how adequate are the current recommendations to prevent vitamin D deficiency in mothers and children? Although vitamin D supplementation is effective in preventing vitamin D deficiency, the optimal vitamin D requirement in women and children is still unknown.12 21 71 In the past, studies by Delvin et al,72 Mallet et al73 and Cockburn et al74 showed that vitamin D supplements below 2000 IU/day did not effectively prevent deficiency. In pregnant women treated with 1000 IU vitamin D/day, maternal serum 25(OH)D levels ranged from a mean of 9.5 nmol/l at baseline to 25.3 nmol/l after receiving 1000 IU vitamin D/day during the last trimester.73 The post-supplementation value is consistent with the definition of deficiency.21 In a more recent study,75 supplementation of pregnant women belonging to minority groups in the UK with 800-1600 IU of vitamin D during pregnancy increased serum 25(OH)D levels from a mean of 14.5 nmol/l at baseline to only 28 nmol/l at term. In ...
The present study is one of the few studies investigating vitamin D status in the pediatric population in the southern region of the United States. In particular, this study is the first to address 25-hydroxyvitamin D levels over 4 seasons in a cohort of black and white adolescents living at southern US latitudes. Our data demonstrate that low vitamin D status is common among adolescents residing in the southeastern region and is related to various adiposity and lifestyle factors.. From NHANES III (1988-1994)2 to NHANES 2000-2004,2,24 the prevalence of vitamin D deficiency (25-hydroxyvitamin D levels of ≤50 nmol/L) in black and white adolescents increased from 28% to 48% and that of vitamin D insufficiency (25-hydroxyvitamin D levels of ≤75 nmol/L) increased from 66% to 81%. More importantly, ∼70% of the black adolescents in NHANES 2000-2004 had winter serum vitamin D deficiency, which might have important implications for known health disparities.24 The NHANES provided key information ...
It is recommended to treat patients suspected of vitamin D deficiency empirically. This recommendation is made after due consideration of the drug cost compared to vitamin D laboratory test costs, and the negligible risk of vitamin D3 toxicity at advised doses. If testing is performed, deficiency is noted to be recognised locally as a serum 25OHD level of less than 25nmol/L (less than 10 nmol/L in NDDH and RD&E). Serum calcium levels should be tested before starting a calcium-containing product or treatment dose vitamin D. Specialist advice should be sought before starting patients with granulomatous disease, tuberculosis or active sarcoidosis on vitamin D therapy due to the risk of hypercalcaemia with high doses of vitamin D. All patients should be provided advice on sun exposure and dietary sources of vitamin D (although it should be noted that only a small amount of vitamin D comes from the diet). Patients with vitamin D deficiency may require loading treatment with pharmacological strength ...
There are numerous publications regarding metabolism of vitamin D in humans, but also in other species. These publications often deal with vitamin D metabolism down to the atoms level - not something absolutely needed for somebody wanting to prevent and avoid vitamin D deficiency.. For most people, it is important to know few facts about:. - vitamin D structure - it is based on cholesterol derivative from which body can (when exposed to UVB radiation) produce vitamin D. Daily amounts of needed cholesterol are usually more than enough for normal vitamin D production due to UVB radiation. Also, when needed, body produces its own cholesterol, so lack or low levels of cholesterol (both HDL (good cholesterol) and LDL (bad cholesterol)) in human nutrition cant cause vitamin D deficiency.. - body can produce vitamin D with the help of UVB rays, so moderate sun exposure is good for health and well being. Actually, active form of vitamin D is NOT produced in the skin.. - vitamin D blood levels are ...
NaturalPath) A recent study out of the University of Sheffield shows there may be a link between vitamin D levels and irritable bowel syndrome (IBS).. This study looked at 51 participants all with IBS, and found that 82 percent were vitamin D deficient. When participants rated their quality of life, there also appeared to be an association between vitamin D levels and the severity of the deficiency. For example, those with lower rated quality of life, based on how IBS affects activities of daily living, showed lower vitamin D levels and a greater deficiency.. Although there is no single known cause that is responsible for IBS, these findings suggest there may be a need to consider supplementation of vitamin D in this population. It is also not been confirmed whether vitamin D deficiency is solely a consequence of the disease, but regardless, insufficient vitamin D status should be addressed in patients with IBS. It is suggested that these patients may also benefit from supplementation, as ...
The results of various studies show severe Vitamin D deficiency across India and Pakistan in all age groups, as well as insufficiency in populations of South-East and East Asia.
Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain. Arch Intern Med. 2007 May 14; 167(9):893-902 ...
Vitamin D, the sunshine vitamin, has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, cardiovascular disease and infectious diseases. Vitamin D deficiency is now recognized as a global pandemic. The major cause for vitamin D deficiency is the lack of appreciation that sun exposure has been and continues to be the major source of vitamin D for children and adults of all ages. Vitamin D plays a crucial role in the development and maintenance of a healthy skeleton throughout life. There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much
You know that our digestive system plays perhaps the most important role in our health-it recognises the nutrients in the food that we eat, separates them from the rest and creates energy for the body. But did you know that mitochondria perform a similar function at a cellular level? Any improvement in mitochondrial function is beneficial to our wellbeing.. According to new research from Newcasle University, Vitamin D is vital for mitochondria to work well and good Vitamin D levels help improve our energy levels as well as keep our muscles working efficiently.. For the study, the team employed non-invasive magnetic resonance scanning to measure the energy levels and muscle fatigue of 12 patients with severe vitamin D deficiency. They were again tested after being given Vitamin D supplements.. Examining this small group of patients with vitamin D deficiency who experienced symptoms of muscle fatigue, we found that those with very low vitamin D levels improved their muscle efficiency ...
Adequate vitamin D status is necessary throughout life in terms of maintaining bone strength, calcium and phosphorus balance, as well as prevention of rickets in children and osteomalacia in adults. The accepted biomarker used for the assessment of vitamin D status is circulating total 25-hydroxyvitamin D (25(OH)D) concentration, which is comprised of the sum of 25-hydroxyvitamin D3 (25(OH)D3) and 25-hydroxvitamin D2 (25(OH)D2) The use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of total 25(OH)D has also enabled the detection of low concentration, minor vitamin D metabolites in serum. The aims of this work were to examine the impact of three such minor vitamin D metabolites, 25(OH)D2, 24,25-dihydroxyvitamin D (24,25(OH)2D), and 3 epimer of 25(OH)D3 (3-epi-25(OH)D3) on the assessment of vitamin D nutritional status and also to provide further insight and refinement of our understanding of the vitamin D metabolic pathway. This required the development and ...
Vitamin D - Part 2 In the first article of this series, I explained what is vitamin D, why do we need this vitamin, what is the best way to know if an individual is deficient in vitamin D, what is the definition of vitamin D deficiency, what is considered a healthy vitamin D level, and what vitamin D deficiency can cause. In this article, I am going to talk about the common risk factors for vitamin D deficiency, the increased use of supplements, the risks of mega doses of vitamin D, vitamin D to
Can an extreme vitamin D deficiency increase the risk of developing dementia?. A recent study appearing in the journal Neurology supports the link between severe deficiency in vitamin D and an increased risk of developing dementia.. A team of researchers at the University of Exeter found that the higher the vitamin D deficiency, the higher the risk of developing dementia and Alzheimers disease.. Study participants who were severely Vitamin D deficient were found to be more than twice as likely to develop Dementia and Alzheimers disease.. Research revealed that those who were moderately deficient in vitamin D had a 53 per cent increased risk of developing dementia. This risk increased to 125 per cent in those who were severely Vitamin D deficient.. The research team was led by Dr Llewellyn who has said: We expected to find an association between low Vitamin D levels and the risk of dementia and Alzheimers disease, but the results were surprising - we actually found that the association was ...
PURPOSE: To report the vitamin D status in adults from seven European countries and to identify behavioural correlates.. METHODS: In total, 1075 eligible adult men and women from Ireland, Netherlands, Spain, Greece, UK, Poland and Germany, were included in the study.. RESULTS: Vitamin D deficiency and insufficiency, defined as 25-hydroxy vitamin D3 (25-OHD3) concentration of ,30 and 30-49.9 nmol/L, respectively, were observed in 3.3 and 30.6% of the participants. The highest prevalence of vitamin D deficiency was found in the UK and the lowest in the Netherlands (8.2 vs. 1.1%, P , 0.05). In addition, the prevalence of vitamin D insufficiency was higher in females compared with males (36.6 vs. 22.6%, P , 0.001), in winter compared with summer months (39.3 vs. 25.0%, P , 0.05) and in younger compared with older participants (36.0 vs. 24.4%, P , 0.05). Positive dose-response associations were also observed between 25-OHD3 concentrations and dietary vitamin D intake from foods and supplements, as ...
Question Does high-dose vitamin D supplementation (2000 IU/d) help to prevent wintertime viral upper respiratory tract infections compared with standard-dose vitamin D supplementation (400 IU/d) among preschool children? Findings In this multisite randomized clinical trial that included 703 children, the number of wintertime laboratory-confirmed viral upper respiratory tract infections was higher in the high-dose group than the…
Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.. Objective To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.. Design, Setting, and Participants Examination of 141 single-nucleotide polymorphisms in a discovery cohort of 1514 white participants (who were recruited from 4 US regions) from the community-based Cardiovascular Health Study. Participants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up ...
Results Serum vitamin D3 assessment was available for 85.4% (158/185) patients during the previous 12 months. First measured vitamin D3 levels were used for primary analysis showing a mean clinic vitamin D3 level of 45.1nmol/L. Normal vitamin D3 levels (,72nmol/L) occurred in 18.9%, 14.6% had insufficient levels (52-72nmol/L) and 65.5% had deficient levels (,52nmol/L). Severe deficiency (,20nmol/L) occurred in 14.6%. Vitamin D deficiency showed highest prevalence during Winter, Autumn and Spring(83-79%) and lowest level in Summer (53.3%). Two thirds of patients received a course of vitamin D replacement therapy during the year.. Vitamin D deficient showed no difference compared to normal vitamin D3 status patients in atopic status, spirometry, inhaled medication usage, maintenance oral steroid use, Omalizumab use and asthma hospitalisations. No significant difference was observed between the two groups in respect to comorbidities like GORD, rhinitis, COPD, bronchiectasis, food allergy and ...
Supplementation to raise vitamin D levels does not improve lipids. The investigators also performed a longitudinal analysis to assess the impact of therapy to correct vitamin D deficiency on lipid levels. Longitudinal studies evaluate changes in a study population over time. Pharmacological, oral vitamin-D therapy is typically administered to raise vitamin D levels in patients with vitamin D deficiency, although over-the-counter supplements are also widely available. The longitudinal study examined data for 8,592 patients re-tested between four and 26 weeks. It showed that raising vitamin D levels from deficient to optimal levels had no statistically significant effect on LDL cholesterol or triglycerides, and had a small, but clinically minimal impact on total and HDL cholesterol. The seemingly conflicting findings of the cross-sectional analysis and longitudinal analysis suggest that while vitamin D deficiency is associated with an unfavorable lipid profile, correcting a deficiency through ...
Improved insulin sensitivity and glucose tolerance may be attributable to vitamin D sufficiency. An experimental design was created to investigate the use of phototherapy to increase serum vitamin D levels and improve circulating blood glucose levels in pre-diabetics. Seven participants with a pre-diabetic condition were randomly allocated to either 3 months of phototherapy or no therapy. OGTT, HbA1c, and serum vitamin D levels were assessed before and after treatment. In 2 treatment participants, pre-diabetes status was reduced from combined IFG/IGT to iIFG in one and iIGT in the second, while 1 control participant developed combined IFG/IGT and another, type 2 diabetes. HbA1c values improved in the phototherapy group but not in the controls. Phototherapy also increased serum vitamin D levels in the treatment group but not in the controls. This pilot study suggests that the experimental protocol was effective and it should be implemented in a larger sample size to confirm those trends ...
Many of your patients may not be getting their recommended daily intake of vitamin D, which could lead to vitamin D insufficiency or deficiency. Vitamin D insufficiency is defined as 25-hydroxyvitamin D (25(OH)D) of 20-29 ng/mL, while vitamin D deficiency is defined as less than 20 ng/mL.1. Physicians typically test for vitamin D in patients who are dark-skinned, have osteoporosis, receive little or no sun exposure, or are advanced in age. But other at-risk patient types may benefit from routine testing, too.1,2. Do you know which lesser-known patient types are at risk of vitamin D deficiency? Take a look at this list and learn how you can help your patients by testing for vitamin D.. ...
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Zosky adds because of the nature of the study its not known if the changes in lung function and structure were from vitamin D deficiency in the mother that occurred in utero, or a direct result.. The researchers say the study supports past epidemiological studies suggesting low vitamin D levels contribute to asthma and COPD.. The differences we observed in lung volume and lung mechanics, which were substantial and physiologically relevant, raise serious concerns regarding the increased prevalence of vitamin D deficiency in communities around the world. The results also raise concerns about the potential this deficiency may have on lung health, and in particular, the potential impact deficiency may have on the susceptibility to obstructive lung disease.. The study is the first to to show the causal relationship between low levels of vitamin D and altered lung function and structure. The researchers suggest more studies. Supplementing vitamin D might improve lung health for susceptible patients ...
BACKGROUND:. First Nations children are at higher risk for vitamin D deficiency and rickets.. OBJECTIVE:. To assess the prevalence of vitamin D deficiency and the correlations between fat mass, parathyroid hormone and dietary habits with serum vitamin D level in a random sample of Cree children eight to 14 years of age.. METHODS:. Serum 25-hydroxyvitamin D (25[OH]D) levels and additional information regarding anthropometrics and dietary habits were obtained from participants in two Cree communities. Vitamin D deficiency and insufficiency was defined as serum 25(OH)D levels ,30 nmol/L and ,50 nmol/L, respectively.. Proportions to estimate the vitamin D status were weighted to account for the complex sampling design, and Pearsons correlation coefficients were used to estimate the associations of milk and fish intake, parathyroid hormone and fat mass with serum 25(OH)D levels.. RESULTS:. Data from 52 healthy Cree children (mean [± SD] age 11.1±2.0 years; 27 boys) were included in the analyses. ...
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: ...
We have conducted what is to our knowledge the first large, prospective, population-based study to examine vitamin D concentrations in relation to a comprehensive adjudicated assessment of dementia and AD. We observed a strong monotonic association between 25(OH)D concentrations and the risk of both incident all-cause dementia and AD. This association was robust to adjustment for a range of potential confounders and the exclusion of dementia cases that occurred within a year of baseline.. The 2 previous studies that have investigated vitamin D and incident dementia have produced conflicting results. The first found that severe vitamin D deficiency was associated with non-AD dementia but not AD risk.16 The second found that severe vitamin D deficiency was associated with AD but not vascular dementia risk.17 However, the first study incorporated a small sample of high-functioning women (n = 40), and the lack of association with AD may reflect limited statistical power. The second study relied on ...
We have conducted what is to our knowledge the first large, prospective, population-based study to examine vitamin D concentrations in relation to a comprehensive adjudicated assessment of dementia and AD. We observed a strong monotonic association between 25(OH)D concentrations and the risk of both incident all-cause dementia and AD. This association was robust to adjustment for a range of potential confounders and the exclusion of dementia cases that occurred within a year of baseline.. The 2 previous studies that have investigated vitamin D and incident dementia have produced conflicting results. The first found that severe vitamin D deficiency was associated with non-AD dementia but not AD risk.16 The second found that severe vitamin D deficiency was associated with AD but not vascular dementia risk.17 However, the first study incorporated a small sample of high-functioning women (n = 40), and the lack of association with AD may reflect limited statistical power. The second study relied on ...
As full-time students, most of us spend a lot of time indoors, and that could be hurting our health.. Vitamin D, one of the 13 vitamins our body needs, is in such deficient quantity in many of us that vitamin D deficiency is now considered a global health problem, affecting an estimated one billion people worldwide.. Vitamin D is a fat-soluble vitamin. Thus, excess is stored in our fat tissue, unlike water-soluble vitamins like vitamin C, excess of which is expelled through urine. You would think that this would help us to keep our vitamin D levels up to where they should be - with enough stored in our fat cells to use in times of need.. The problem is that vitamin D is naturally present in very few foods, such as the flesh of fatty fish such as salmon and tuna, as well as beef liver, cheese and egg yolks.. Fortified foods provide most of the vitamin D in the diets of Americans. Most milk sold in the U.S. is fortified with vitamin D. Companies began adding vitamin D to milk in the 1930s to ...
Vitamin D deficiency is often known to provoke certain heart diseases. According to medical experts, when vitamin D levels are low, the calcium levels in the arteries are higher and thus heart problems arise. The calcium creates clogs inside the arteries, which usually leads to a heart failure or a stroke.. Aside from the listed, other health conditions that may occur as a result of vitamin D insufficiency are: type 2 diabetes, high cholesterol and obesity.. Incorporating More Vitamin D. Getting to know the health issues which can happen if vitamin D is missing from the body, forces us to rethink our nutrition and get those vitamin levels back on track.. Here are the top products full of vitamin D, which, if consumed regularly, will never fail you. Take them regularly and keep your health on the right path: ...
During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed, rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review, we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however, there is evidence
Mon. Apr.1, 2013 by Blanche Levine (NaturalHealth365) Low vitamin D levels can be the most damaging influence on our genetic health, according to professor George Ebers, Action Medical Research professor of Clinical Neurology
By Adam MarcusNEW YORK (Reuters Health) - Many women have low blood levels of vitamin D early in pregnancy, but whether thats a problem for their developing babies is uncertain, researchers have found.The new study, by scientists in Australia, suggests that vitamin D deficiency among pregnant women may even be the norm, although defining deficiency is tricky.However, the researchers did not find any solid evidence that it stunts fetal growth or causes other pregnancy-related complications.The researchers analyzed 18 previous studies in which vitamin D levels were assessed in women in their first 3 months of pregnancy. Of those, five studies included information about the outcome of the pregnancy, including low birth weight and preeclampsia, a maternal complication that can be life-threatening.The researchers, who reported their findings April 8 in the American Journal of Obstetrics and Gynecology, found no clear definition of vitamin D deficiency during early pregnancy. Rather, women in the previous