TY - JOUR. T1 - Serum vitamin D concentrations and unexplained elevation in ALT among US adults. AU - Liangpunsakul, Suthat. AU - Chalasani, Naga. PY - 2011/7. Y1 - 2011/7. N2 - Background: Low serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT. Methods: A total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels. Results: Participants with unexplained elevation in ALT had significantly lower serum ...
Background: Hydroxymethylglutaryl‑coenzyme A reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. The purpose of this study was to determine the effect of simvastatin on serum Vitamin D status in dyslipidemic patients as Vitamin D status has an impact on monocyte/macrophage function and may also contribute to cardiovascular risk. Methods: Selected individuals (n = 102) were treated with simvastatin (40 mg/day), or matching placebo in a randomized, double‑blind, placebo‑controlled, crossover trial. Each treatment period (with simvastatin or placebo) lasted for 30 days and was separated by a 2‑week washout phase. Serum Vitamin D concentration was assessed pre‑ and post‑treatment. Results: Seventy‑seven completed the trial, noncompliance with the study protocol and drug intolerance or relocation were the causes for drop‑out. No significant ...
INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between ...
Vitamin D is a fundamentally important hormone involved in calcium absorption, bone mineralization and parathyroid hormone production. Vitamin D deficiency may result in a myriad of diseases, such as osteomalacia, rickets and has more recently been identified as a risk factor for diabetes. Accurate determination of serum vitamin D levels is, therefore, paramount when assessing an individual for related pathologies against an appropriate reference range for interpretation. The purpose of this study was to assess vitamin D status between healthy Caucasian and healthy Asian populations of Peterborough, taking into account seasonal serum vitamin D variation. In addition, we evaluated whether a reference range for serum vitamin D of the local population should be race and/or seasonal specific. Using a Chromsystems high-pressure liquid chromatography vitamin D2/D3 methodology upon Agilent 1100 hardware, serum vitamin D status was assessed in 200 subjects of varying age, gender and ethnicity using ...
A recent study has found a further link between low vitamin D levels and premenopausal breast cancer.The study, by researchers from the University of California, San Diego School of Medicine, examined 1,200 healthy women and found that those whose serum vitamin D levels were low during the three-month period just before diagnosis had approximately three times the risk of breast cancer as women in the highest vitamin D group. Several previous studies have shown that low serum levels of vitamin D are associated with a higher risk of premenopausal breast cancer.
Vitamin D can be made in the skin by exposure to sunlight and can be found in certain foods. Vitamin D levels are alarmingly low in many North American children. Several health issues have been linked with low vitamin D. These include colds caused by viruses and asthma attacks. However, no study has determined whether vitamin D supplementation can reduce the risk of these conditions in young children where they are most common and most severe.. The goals of this study are to determine whether wintertime high dose vitamin D supplementation of preschoolers can prevent colds and asthma attacks. The investigators also aim to work out how much money would be saved by the health care system and society if preschoolers were routinely supplemented with Vitamin D during the winter. The investigators believe that preschoolers receiving high dose vitamin D supplementation during the wintertime will be less likely to have colds, asthma attacks, and low vitamin D levels and will be less likely to use the ...
Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses. Controversy continues on the relative potency of vitamin D2 compared to D3 and of daily compared to weekly or monthly doses, in increasing/maintaining total 25 OH vitamin D level.. The investigators plan to conduct a controlled trial to compare the effect of various vitamin D supplements on 25 OH vitamin D levels in healthy adults with starting 25 OH vitamin D level between 20 to 50 nmol/L. ...
The present study used a systematic review approach to identify relevant randomised control trials (RCT) with vitamin D and then apply meta-regression to explore the most appropriate model of the vitamin D intake-serum 25-hydroxyvitamin D (25(OH)D) relationship to underpin setting reference intake values. Methods included an updated structured search on Ovid MEDLINE; rigorous inclusion/exclusion criteria; data extraction; and meta-regression (using different model constructs). In particular, priority was given to data from winter-based RCT performed at latitudes ,49•58°N (n 12). A combined weighted linear model meta-regression analyses of natural log (Ln) total vitamin D intake (i.e. diet and supplemental vitamin D) versus achieved serum 25(OH)D in winter (that used by the North American Dietary Reference Intake Committee) produced a curvilinear relationship (mean (95% lower CI) serum 25(OH)D (nmol/l) = 9•2 (8•5) Ln (total vitamin D)). Use of non-transformed total vitamin D intake data ...
Falls in the elderly, as well as fall-related adverse outcomes such as low trauma bone fractures, are events that could be prevented. Epidemiological studies conducted over the past 15 years provide an increasing number of arguments in favor of an action of vitamin D on muscles and CNS. Vitamin D improves postural balance, propulsion and also executive functions and navigation abilities among older adults. Vitamin D supplementation thus not only determines gait performance, but also prevents the occurrence of falls and their complications among older adults. Mixed data regarding the absence of effect of vitamin D and calcium supplementation are mainly due to the fact that some confounders were not taken into account, but also to the baseline serum vitamin D concentration on initiation of treatment, as a low serum vitamin D concentration appears to be associated with better efficacy. The prescription of at least 800 IU of vitamin D daily in insufficient elderly subjects is a simple intervention ...
BACKGROUND: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with ... read more vitamin D insufficiency/deficiency. METHODS: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (,50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D ,50 nmol/l) was reached in ,75% without side effects nor reaching toxic levels. RESULTS: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency ...
Results We studied 117 Participants, 62 females and 55 males, age was 71 (5) years, of who 61 received 3,750 IU of vitamin D, and 55 received 600 IU/day. Vitamin D receptor genetic polymorphisms distribution was comparable in both arms. Daily vitamin D intake excluding provided supplements was 7.59 (1.21) mcg and 8.53 (1.36) mcg from the 24 h recall, and food frequency questionnaires, respectively (p was NS between the two arms). Calories, calcium, protein, carbohydrate and fat mean intake was also similar across both arms. The high-dose group achieved significantly higher 25OH-vitamin D serum levels at twelve months 34.9 (9.3) ng/ml compared to low-dose, 21.9 (6.1) ng/ml (p,0.0001). Difference between arms remained significant adjusting for gender, baseline BMI, Fok, Bsml and Taq genetic polymorphism, baseline serum vitamin D and dietary intake of vitamin D, calcium, calories, proteins, carbohydrates and fats. None of these dietary intake measures was found to have significant contribution to ...
In this study, data were available with 451 kidney stone cases and 482 controls for the analysis. This work provided convincing evidence that serum vitamin D level in kidney stone patients was significantly higher than that in non-kidney stone controls. The associations were also significant both in Europe and in Asia populations.. In our study, significant between-study heterogeneity was found between serum vitamin D levels and kidney stone risk. Previous paper [21] had reported that heterogeneity is common in the meta-analyses. To explore the potential sources of between-study heterogeneity is therefore an essential component of meta-analysis. The high degree of heterogeneity might have arisen from publication year, study design and geographic locations. Therefore, we used meta-regression to explore the causes of heterogeneity by covariates. However, no covariate had significant impact on the high between-study heterogeneity among those mentioned above. Considering the pooled meta-analysis was ...
This study was designed to assess the beneficial effects of high-dose (cholecalciferol) vitamin D supplementation on metabolic profiles and pregnancy outcomes among pregnant women at risk for pre-eclampsia. This randomized double-blind placebo-controlled clinical trial was performed among 60 pregnant women at risk for pre-eclampsia according to abnormal uterine artery Doppler waveform. Subjects were randomly divided into 2 groups to receive 50-000 IU vitamin D supplements (n=30) or receive placebo (n=30) every 2 weeks from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline study and 12 weeks after the intervention to quantify relevant variables. Newborns anthropometric measurements were determined. Pregnant women who received cholecalciferol supplements had significantly increased serum 25-hydroxyvitamin D concentrations (+17.92±2.28 vs. +0.27±3.19-ng/ml, p,0.001) compared with the placebo. The administration of cholecalciferol supplements, compared with the ...
Background and Objective: Low Vitamin D levels have been implicated as contributing to statin myalgia, but studies on the relationship between Vitamin D and statin-associated muscle side effects (SAMS) have produced discrepant results. We examined the influence of baseline and change in Vitamin D levels in patients with self-reported statin myalgia who developed muscle symptoms during a statin-placebo cross-over trial.. Methods: Statin myalgia was verified in 120 patients with prior statin muscle complaints using an 8-week randomized, double-blind crossover trial of simvastatin (SIMVA) 20 mg/d and placebo. Anthropometrics, medical histories, demographics and serologic data (including 25 (OH)Vitamin D) were measured at each phase of the trial.. Results: Forty three (35.8%) patients met the study criteria for myalgia, experiencing muscle pain on SIMVA but not placebo. Serum Vitamin D levels (mean ± standard deviation) prior to simvastatin treatment were not different between patients who did ...
Combining results from 12 studies of vitamin D intake and 7 studies of circulating 25(OH)D, high compared with low dietary vitamin D intake was associated with an 11% marginally decreased risk of colorectal adenomas and high versus low circulating 25(OH)D with a statistically significant 30% decreased risk.. The inverse association with colorectal adenomas was similar for dietary intake compared with total vitamin D intake (OR, 0.90 versus 0.89), whereas no association with supplemental vitamin D intake was found (OR, 1.0). That total intake did not have a stronger association compared with dietary sources alone was unexpected given that dietary sources of vitamin D are uncommon, and in some populations, supplements are an important source of total vitamin D intake. Furthermore, supplemental sources of vitamin D may contain folate and other micronutrients that could enhance an inverse relation between supplemental vitamin D and adenomas (36, 37).. The lack of association with supplemental ...
What is the optimal vitamin D level?. As already mentioned, different sources recommend different vitamin D levels - currently there is no clear opinion. Official bodies, such as the German Nutrition Society, recommend a vitamin D level of 20 ng/ml. While the Institute of Medicine considers a level of 20 ng/ml to be sufficient, the minimum vitamin D level recommended by the Vitamin D Council is 40 ng/ml. The Grassroots Health initiative recommends a level of 40-60 ng/ml. Dr. Raimund von Helden is convinced that an optimal vitamin D level is between 50-90 ng/ml.. It can now be assumed that the average value should be around 30 - 80 ng/ml. However, the optimal value for a vitamin D level is above 50 ng/ml in almost all studies.. The vitamin d rapid self-test from kiweno interprets vitamin D values as follows:. 0-10 ng/ml - severe deficiency. 11-30 ng/ml - deficiency. 31-100 ng/ml - optimal supply. , 100 ng/ml - Overdose. Vitamin D filling up and maintenance. In the case of a severe deficiency, we ...
Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial-a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offsprings bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Womens Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks gestation [r = -0.16, 95% confidence interval (CI) -0
Other studies, however, posted no significant change on bone mineral density upon taking vitamin D supplements, researchers highlighted.. "Most healthy adults do not need vitamin D supplements" studys lead researcher, Professor Ian Reid from the University of Aucklands Bone Research Group said. "Our data suggest that the targeting of low-dose vitamin D supplements only to individuals who are likely to be deficient could free up substantial resources that could be better used elsewhere in health care," the researchers wrote in an article published online October 11 in the Lancet.. "This systematic review provides very little evidence of an overall benefit of vitamin D supplementation on bone density. Continuing widespread use of vitamin D for osteoporosis prevention in community-dwelling adults without specific risk factors for vitamin D deficiency seems inappropriate," he added.. The researchers recommend that such supplements should be prescribed only to people who have very low levels of ...
Vitamin D is called the sunshine vitamin - because we can usually get it from the suns ultraviolet rays; it supports bone development and is needed for calcium and vitamin C absorption, and it supports the nervous system. Vitamin D plays a dual role as both a vitamin and a hormone that stimulates the body to absorb calcium. Natural Factors Vitamin D3 is derived from sheep wool lanolin.Vitamin D3 (cholecalciferol from animal sources). Vitamin D3 is the form found in fish oils and eggs, and is produced by sunlight on human skin. Natural Factors Vitamin D3 is derived from sheep wool lanolin. Vitamin D plays a dual role as both a vitamin and a hormone that stimulates the body to absorb calcium. Vitamin D, calcium, and phosphorus are needed to keep bones strong. Without vitamin D even a diet adequate in calcium will not help because the body needs vitamin D to absorb calcium. People with low vitamin D levels tend to have soft, thin bones, predisposing them to fractures, especially hip
Objective: Vitamin D deficiency (serum 25-hydroxyvitamin D˂25nmol/L) is extremely common in western-dwelling South Asians but evidence regarding vitamin D supplement usage in this group is very limited. This work identifies demographic, dietary and lifestyle predictors associated with vitamin D supplement use.. Design: Cross-sectional analysis of baseline vitamin D supplement use data.. Setting: UK Biobank cohort.. Subjects: In total, n 8024 South Asians (Bangladeshi, Indian, Pakistani), aged 40-69 years.. Results: Twenty-three % of men and 39% of women (P˂0.001) [22% of Bangladeshis, 32% of Indians, 25% of Pakistanis (P˂0.001)] took a vitamin D containing supplement. Median vitamin D intakes from diet were low at 1.0-3.0 micrograms per day, being highest in Bangladeshis and lowest in Indians (P˂0.001). Logistic regression modelling showed that females had a higher odds of vitamin D supplement use than males (odds ratio (OR) = 2.02; 95% confidence interval (CI) 1.79 to 2.28). A lower ...
What Is It?. Vitamin D 3 enhances calcium absorption and retention, a key nutritional role in supporting healthy bones, and may play a potential role in cardiovascular, colon and cellular health. Vitamin D levels have been shown to decline with age, due primarily to a reduction in either absorption or metabolism by the liver. Decreased exposure to sunlight, a vegetarian diet, or a low intake of vitamin D fortified foods also play a role in inadequate vitamin D levels.*. Uses For Vitamin D 3. Bone Health: Vitamin D promotes intestinal calcium and phosphorous absorption and reduces urinary calcium loss, essential mechanisms for maintaining proper calcium levels in the body and for healthy bone composition. Clinical studies involving vitamin D supplementation suggest the importance of vitamin D in addition to calcium for bone health. Vitamin D supplementation alone may also support bone health.*. Cardiovascular Support: Vitamin D may also provide cardiovascular support for some individuals, which ...
What Is It?. Vitamin D 3 enhances calcium absorption and retention, a key nutritional role in supporting healthy bones, and may play a potential role in cardiovascular, colon and cellular health. Vitamin D levels have been shown to decline with age, due primarily to a reduction in either absorption or metabolism by the liver. Decreased exposure to sunlight, a vegetarian diet, or a low intake of vitamin D fortified foods also play a role in inadequate vitamin D levels.*. Uses For Vitamin D 3. Bone Health: Vitamin D promotes intestinal calcium and phosphorous absorption and reduces urinary calcium loss, essential mechanisms for maintaining proper calcium levels in the body and for healthy bone composition. Clinical studies involving vitamin D supplementation suggest the importance of vitamin D in addition to calcium for bone health. Vitamin D supplementation alone may also support bone health.*. Cardiovascular Support: Vitamin D may also provide cardiovascular support for some individuals, which ...
Jarrow Formulas Vitamin D3 2500IU 100 Softgels Vitamin D3 Promotes Calcium and Bone Metabolism Immune Function Vitamin D3 WHAT DOES VITAMIN D3 DO? Jarrow FORMULAS Vitamin D3 provides cholecalciferol, the most bioavailable form of vitamin D. Vitamin D3 is converted by the kidneys into the hormone calcitriol, the active form of vitamin D3. Vitamin D3 enhances calcium and phosphorous absorption, stimulates the synthesis of osteocalcin (an important structural protein in bone), and is involved in proper cell differentiation and immune response. Keep out of the reach of children. Suggested Usage For adults, take 1 softgel every other day with a meal or as directed by your qualified health care consultant. NOTE: Individuals consuming more than 2,000 IU/day of vitamin D should periodically obtain a serum 25-hydroxy vitamin D measurement. If you have a medical condition (especially kidney stones or dysfunction, hyperparathyroidism,
Low bone mineral density has been identified as a risk factor for osteoporotic fracture1 and fracture in childhood.2 Vitamin D supplementation in childhood may be a clinical strategy to maximise peak bone mass in children and, in turn, improve bone mineral density and reduce fracture risk in adulthood. However, the effectiveness of vitamin D supplementation for improving bone density in children is unclear. Therefore, Winzenberg and colleagues performed a systematic review and meta-analysis to evaluate the efficacy of vitamin D supplementation for improving paediatric bone mineral density, including how supplement dose and baseline vitamin D status may impact the outcome.. ...
Effects of low vitamin D level On Body - Vitamin D is crucial for strong and healthy bone and also the teeth. Lacking the recommended amounts in...
Supplementation of the diet with vitamins is a common occurrence and there is debate over whether increased vitamin A intake might promote skeletal fragility. Some studies have suggested that increased vitamin A intake may decrease BMD and promote hip fracture; however, other studies have not shown increased bone loss or increased fracture risk, and in some instances, protection from bone loss by vitamin A has been suggested. Vitamin D plays a major role in calcium absorption and mineral homeostasis. Vitamin D deficiency is common and some studies have suggested that he risk of osteoporosis and fracture may increase when increased vitamin A intake occurs in individuals with low vitamin D levels. It is possible that an increased risk of osteoporosis and fracture might exist for increased vitamin A intake and/or increased intake in the face of low vitamin D, but it appears that additional in vivo animal studies and studies in humans to confirm or dispel these possibilities will be necessary before ...
Vitamin D is actually a hormone, and along with thyroid hormone, is one of the two hormones every cell in your body needs. It regulates hundreds of different pathways throughout the body.. Bone density. Vitamin D has long been known to play a role in preventing breakdown of bones and increasing the strength of the skeletal system.. Mood regulation. Low vitamin D is linked to a 14 percent increase depression and a 50 percent increase in suicide rates. Increasing vitamin D intake can help improve anxiety and depression.. Brain health. Vitamin Ds biologically active form has shown neuroprotective effects including the clearance of amyloid plaques common to Alzheimers Disease. Associations have also been noted between low 25-hydroxyvitamin D and dementia.. Reduced cancer risk. Optimal vitamin D levels are associated with lower rates of cancers of the breast, ovaries, prostate, and pancreas.. Sleep quality. Adequate vitamin D is associated with improved sleep.. Immune regulation. Vitamin D plays a ...
Several factors, including regional UVB levels, vitamin D intake, skin pigmentation, sunlight exposure behaviors, and adiposity may influence in vivo vitamin D levels (21). Seasonal variation in 25(OH)D concentrations have been observed for residents in Boston (10-13), with inadequate vitamin D intake and winter season being independent predictors of hypovitaminosis D (13). We investigated the effects of season and vitamin D intake on NSCLC survival and found that both higher UVB exposure (patients who had surgery in summer) and higher vitamin D intake (diet and supplement) improved lung cancer survival. Patients who had surgery in summer with high vitamin D intake had a 3-fold better RFS and a 4-fold better OS than those with surgery in winter and low vitamin D intake, with all of the other patient groups falling between the two groups (Table 4; Fig. 2). In Cox proportional hazards models, we adjusted for the most important predictors of NSCLC prognosis, including age, gender, smoking status, ...
BACKGROUND People with intellectual disability (ID) are thought to be at an increased risk of fractures. The extent of this increase in risk has been incompletely documented in the literature, and the underlying reasons remain to be elucidated. METHODS The aims of our study were to document the vitamin D status and fracture incidence in an intellectually disabled population, to test for associations between vitamin D status and possible risk factors for reduced vitamin D levels, and to determine the efficacy of oral vitamin D supplementation in restoring appropriate vitamin D levels in those found to be vitamin D insufficient. A 5-year retrospective audit of fractures in 337 individuals with ID receiving health care at a residential facility was performed. Data analysed included age, gender, mobility, dietary status, incident fractures, medications and 25-hydroxyvitamin D levels. Vitamin D insufficient individuals received oral vitamin D supplementation, and had repeat testing to assess treatment
Vitamin D and Brain Function. Over the years, we have been instructed to stay out of the sun and if we do venture outside to slap on the sunscreen. But, in truth, these toxic chemical lotions block out the healing benefits of sunlight and promote many brain disorders. Scientists have proven that low levels of vitamin d increase your risk for cancer, osteoporosis and learning disorders like autism. In the past, we obtained 90% of our vitamin D from the sun. For someone with normal vitamin D
Vitamin D is produced in the body via sunlight. It is also obtained from foods such as oily fish (salmon, mackerel, sardines), fortified milk, cereals, and from supplements. Low vitamin D levels may be caused by a lack of sun exposure, lack of dietary vitamin D, malabsorption, side effects from medications or supplements, chronic diseases such as kidney or liver disease, and other causes. In addition, seniors, infants and toddlers, dark-skinned people, and pregnant or breastfeeding women may be particularly at risk for low vitamin D levels. Now, we are discovering there are other factors that may affect vitamin D levels. The new study explored the importance of skin pigmentation, total cholesterol, and baseline blood levels of vitamin D (measured as 25- hydroxy vitamin D) on vitamin D production after ultraviolet B (UVB) exposure. Participants in this study had four UVB exposures several days apart to the chest and back, and each exposure was equivalent to about 30 minutes of sun exposure in the ...
Vitamin D improved heart health in dieters, green tea reduced abdominal fat, and calcium helped those with low calcium lose more weight, new findings show. In a study of heart health in dieters, researchers noted that losing excess weight cuts the chances of heart disease, and explained that low vitamin D and high parathyroid hormone levels are two new heart health risk factors. About 200 healthy but overweight men and women with low vitamin D levels took 3,320 IU of vitamin D per day or a placebo. After 12 months, vitamin D levels were normal in the vitamin D group but remained low for placebo. Measuring other risk factors, compared to placebo, the vitamin D group had lost 4.5 times the amount of blood fats (triglycerides), had three times lower levels of an inflammatory sign (tumor necrosis factor-alpha) and lower levels of parathyroid hormone. Doctors in a diet study thought that catechins-the powerful antioxidants in green tea-could help the body burn fat. A group of 132 overweight or obese ...
By Mark, Sean Gray-Donald, Katherine; Delvin, Edgard E; OLoughlin, Jennifer; Paradis, Gilles; Levy, Emile; Lambert, Marie BACKGROUND: Adequate vitamin D status is important for bone growth and mineralization and has been implicated in the regulation of autoimmunity, metabolic function, and cancer prevention. There are no reports of population-based studies on the vitamin D status of Canadian youth, a population with mandatory fortification of foods. METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D], the best indicator of vitamin D status, in a school-based cross- sectional sample of representative French Canadian youth (n = 1753) ages 9, 13, and 16 years living in Quebec (latitude: 45[degrees]- 48[degrees]N). Blood samples were collected from January to May 1999. We defined 25(OH)D deficiency as =27.5 nmol/L, hypovitaminosis as =37.5 nmol/L, and optimal as ,75.0 nmol/L. RESULTS: More than 93% of youth in each age and sex group had suboptimal 25(OH)D concentrations. The prevalence of ...
Introduction: Vitamin D deficiency and type 2 diabetes are both common diseases. Numerous studies have examined the relationship between the two. The purpose of this study was to investigate the effect of vitamin D supplementation on glycemic status, lipid profile and inflammatory markers in patients with diabetes. Method: Type of systematic review and ...
Based on epidemiological case-control studies, vitamin D deficiency is now recognized as an independent environmental risk factor for developing multiple sclerosis (MS). Studies indicate that vitamin D, besides regulating bone homeostasis, has immunomodulatory properties thought to be beneficial in MS. It is therefore an attractive and fairly safe candidate for add-on therapy. Certain studies also point towards an inverse correlation between serum vitamin D levels and MRI disease activity or relapse rate in MS patients [1, 2]. However, is there a rationale for vitamin D supplementation in MS patients specifically, besides correcting a documented serum deficiency? One can argue that vitamin D deficiency is also present in a large proportion of the general population in the Northern hemisphere, because of insufficient sunlight exposure, and therefore, supplementation should not be restricted to MS patients only. The article by Faridar et al. in this issue of Acta Neurologica Belgica provides a critical
Calcium / Vitamin D Calcium metabolism • Serum calcium drops.. PTH released.. • In kidney, PTH turns vitamin D into its active form 1,25hydroxycholecalciferol (calcitriol)... It also increases kidneys reabsorption of calcium from urine • Calcitriol acts to aid absorption of calcium from small intestine Calcium metabolism • Dietary sources - Dairy (semi skimmed milk greater content than full fat), sardines, bread, baked beans, cabbage • PTH causes release of calcium from bone into bloodstream. • Absorption of calcium from blood into bone matrix, stimulated by calcitriol Vitamin D metabolism • Vitamin D is produced by the skin in sunlight (cholecalciferol - D3) • Diet adequate in vitamin D is needed to maintain supplies in Winter (D2 and D3) • Dietary sources: - Eggs, dairy products, oily fish, fortified cereals • Skin and dietary sources of vitamin D are metabolised by liver and then kidney, into active form 1,25hydroxycholecalciferol (calcitriol) Vitamin D deficiency • ...
Testosterone is a hormone produced by the pituitary gland in males and by the ovaries in females. Vitamin D is one of the 24 essential vitamins needed by the body for survival and it affects more than 1000 body functions, so any fluctuations in the levels of vitamin D can disrupt many functions. There is a clear connection between vitamin D levels and testosterone levels in the body as the former affects a lot of endocrine functions.. Vitamin D is generally got by skin exposure to sun, it is a fat soluble vitamin and is absorbed in the small intestine and stored in the body tissues. It stays longer in the body when compared to water soluble vitamins and so overdosing on Vitamin D can lead to toxicity as well.. Recent studies correlating Vit D and Testosterone. A study found that men who had sufficient vitamin D in their body had significantly higher levels of testosterone in the body than men who had insufficient vitamin levels. It also states that older men who are on vitamin D supplements are ...
A number of studies have suggested a link between low levels of vitamin D and higher incidence of chronic pain There is a well-established link between low vitamin D and pain due toosteomalacia. There is no clear biological mechanism of how low We searched Medline (PubMed) using various search terms for vitamin D might be causally related to other types of chronic pain, vitamin D (vitamin D; vitamin D2; vitamin D3; 1-alpha-hydroxyvi- though vitamin D is thought to be involved in regulating inflamma- tamin D3; 1-alpha hydroxycalciferol; 1,25-dihydroxyvitamin D3; tory cytokine synthesis , and might be implicated in some hydroxyvitamin D; alfacalcidol; calcidiol; calcitriol; calcifediol; Associations of pain with latitude and season of the year offer calciferol; ergocalciferol; cholecalciferol; and spelling variations circumstantial evidence that vitamin D may be involved. These thereof) and pain*". The last search was conducted on 8 Septem- associations have been suggested for such diverse ...
Objective - Data relating vitamin D status with indices of glucose homeostasis as manifested by A1c in the U.S. adult population are few.. Research Design and Methods - We examined the association between serum 25-OH vitamin D and A1c levels in 9773 adults (age ≥ 18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders.. Results - Serum 25-OH vitamin D levels were inversely associated with A1c levels in subjects age 35 to 74 years (p=0.0045) and those who did not report a history of diabetes mellitus (p=0.0282).. Conclusions - These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1c levels for vitamin D insufficiency should be considered.. ...
As we all know, too much sun can cause skin cancer and we in Australia and also in New Zealand already have the highest rate of skin cancer in the world. But the sun is also the main source of vitamin D and a significant part of our population is deficient in this vital nutrient.. UNIQUE VITAMIN D Vitamin D is a fat-soluble vitamin (which means it can be stored in the body) and it is unique because unlike most vitamins which we get from foods and drinks, most of our vitamin D is produced when a fatty substance in our skin reacts with the sun rays. The body then convert this into vitamin D and stores it for when we need it. Circa 90% of our vitamin D is produced in this way and circa 10% comes from our food.. Are we getting enough? It is important to get enough vitamin D for several reasons.. Healthy Bones Vitamin D is essential for bone health because it helps to absorb calcium and other minerals we need to build strong bones and teeth. Over time, low vitamin D levels can lead to conditions like ...
To the Editor:. We read with interest the paper by Hsia and colleagues1 in which the authors demonstrated that a daily vitamin D supplement of 400 IU (10 μg) in combination with 1000 mg calcium has no beneficial effects on cardiovascular risk. In our opinion, the data interpretation is complicated by the lack of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D (calcitriol) measurements. It may be that the vitamin D dose was too low to influence circulating calcitriol concentrations. It may also be that baseline 25-hydroxyvitamin D concentrations were already sufficient enough to produce adequate amounts of calcitriol. Calcitriol is the only vitamin D metabolite with known physiological actions. Experimental data demonstrate that calcitriol has important protective vascular effects such as suppression of renin activity, inhibition of vascular calcification, and reduction of thrombogenicity.2 Several retrospective studies already indicate that calcitriol and other active vitamin D analogs reduce ...
To explore reasons for heterogeneity, we conducted subgroup analyses to investigate whether effects of vitamin D supplementation on risk of acute respiratory tract infection differed according to baseline vitamin D status, dosing frequency, dose size, age, body mass index, the presence or absence of comorbidity (asthma or chronic obstructive pulmonary disease), and influenza vaccination status. Race or ethnicity was not investigated as a potential effect modifier, as data for this variable were missing for 3680/10 933 (34%) participants and power for subgroup analyses was limited by small numbers in many racial or ethnic subgroups that could not be meaningfully combined. Table 2⇑ presents the results. Subgroup analysis revealed a strong protective effect of vitamin D supplementation among those with baseline circulating 25-hydroxyvitamin D levels less than 25 nmol/L (adjusted odds ratio 0.58, 0.40 to 0.82, NNT=8, 5 to 21; 538 participants in 14 studies; within subgroup P=0.002; see Cates plot, ...
The objective was to assess the vitamin D status in healthy 12-month-old infants in relation to quantity and sources of dietary vitamin D, breastfeeding and seasons. Subjects were 76 12-month-old infants. Serum levels of 25-hydroxyvitamin D (25(OH)D) ≥ 50 nmol/L were considered indicative of vitamin D sufficiency and 25(OH)D < 27.5 nmol/L as being indicative of increased risk for rickets. Additionally, 25(OH)D > 125 nmol/L was considered possibly adversely high. Total vitamin D at 9-12 months (eight data collection days) included intake from diet and supplements. The mean ± SD of vitamin D intake was 8.8 ± 5.2 μg/day and serum 25(OH)D 98.1 ± 32.2 nmol/L (range 39.3-165.5). Ninety-two percent of infants were vitamin D sufficient and none at increased risk for rickets. The 26% infants using fortified products and supplements never/irregularly or in small amounts had lower 25(OH)D (76.8 ± 27.1 nmol/L) than the 22% using fortified products (100.0 ± 31.4 nmol/L), 18% using supplements (104.6
Vitamin D is called the "sunshine vitamin" because it is produced by the body when the skin is exposed to ultraviolet (UV) rays from the sun. Vitamin D can also be obtained from foods such as fish and fortified milk and from supplements. When this fat-soluble vitamin enters the body it is converted in the liver to 25-hydroxyvitamin D. This is one of several important forms of vitamin D, and is the form that researchers and clinicians use as an indicator of vitamin D status in individuals. "Vitamin D is especially critical in maintaining bone health, and there is evidence that many older Americans have low blood levels of vitamin D, which can put them at risk for bone fractures and osteoporosis," says Dawson-Hughes, who is also a professor at Tufts University School of Medicine.. "These results cannot be carried over to other populations, such as young people, or elderly living in different climates. However, if low vitamin D stores are not attributed to low sunlight exposure in this population, ...
The body needs vitamin D to absorb calcium. A lack of vitamin D can weaken bones, which increases the risk of fracture. In addition to bone health, vitamin D is essential to promote muscle mass. One study found that low vitamin D levels affected muscle strength in U.S. college athletes. Athletes with lower vitamin D levels performed worse on several tests of muscle strength compared to athletes who had higher levels of vitamin D.. Good sources of vitamin D include oily fish, such as tuna and sardines, as well as egg yolks and fortified milk. Sunlight also contributes to the bodys production of vitamin D. Many experts recommend that female adolescent athletes take a daily vitamin D supplement of 500 to 1,000 IU, or even more if a deficiency has been identified. A blood test for vitamin D levels is easily accessible.. Many nutrition experts also recommend taking vitamin K along with vitamin D. In addition to vitamin K supporting bone health, it also helps direct calcium out of the soft tissues ...
BACKGROUND: People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people with IDs previously treated for vitamin D deficiency (1) long-term adherence to vitamin D supplementation and (2) bone mineral density (BMD), as an indicator for risk of fractures, according to vitamin D supplementation and other factors. METHOD: We recorded height, weight, medical, pharmacological, dietary and lifestyle assessment. Blood sample were taken for vitamin D and related analytes. dual-energy X-ray absorptiometry for BMD was performed. RESULTS: Of 51 study participants (mean [standard deviation, SD] age 51.5 [13.6] years, 57% male), 41 (80.4%) were taking vitamin D and 10 were not. Mean [SD] serum vitamin D was 81.3 [21.3] vs. 25.2 [10.2] nmol/L (P | 0.0001), respectively. Thirty-six participants underwent a dual-energy X-ray absorptiometry scan, which showed osteoporosis in
This basic review seeks desperately to evaluate the drug receptor interaction between calcium and moxifloxacin and answer provides recommendations for concurrent use of these drugs. We may make some assumptions on calcium based on the dawson - hughes b, harris ss, krall ea, dallal ge: effect somewhat of calcium sensitive and vitamin d supplementation on bone density in men and women 65 years of age or were older. n engl j med. 1997 sep 4 ; 337 (
Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations in 33 996 individuals of European descent from 15 cohorts. Five epidemiological cohorts were designated as discovery cohorts (n=16 125), five as in-silico replication cohorts (n=9367), and five as de-novo replication cohorts (n=8504). 25-hydroxyvitamin D concentrations were measured by radioimmunoassay, chemiluminescent assay, ELISA, or mass spectrometry. Vitamin D insufficiency was defined as concentrations lower than 75 nmol/L or 50 nmol/L. We combined results of genome-wide analyses across cohorts using Z-score-weighted meta-analysis
Other studies have focused upon the safety implications of vitamin D supplementation. Armin Zitterman and colleagues, of the Heart and Diabetes Center at Ruhr University Bochum, Germany, suggested that more accurate dosing should be based upon body weight to avoid vitamin D intoxication. One of the hallmarks of taking too much vitamin D is hyperglycemia, which can lead to further health issues.. However, a study performed by Prentice et al., (2013) found that a combination of both calcium and vitamin D supplements could reduce the chances of postmenopausal women in the U.S. developing hip fractures and colorectal cancer.. Speaking to the Daily Mail, Claire Bowring, who works for the National Osteoporosis Society, summarizes her conclusions on the study. Bowring explains that the best source of vitamin D, for the majority of people, is from "… safe summer sunlight exposure.". Professor Reid states that use of vitamin D supplements in healthy adults represents a drain on finances and resources, ...