Vitamin A deficiency leads to altered lipid metabolism in the liver. The expression pattern of metabolic genes in vitamin A-sufficient (VAS) versus vitamin A-deficient (VAD) liver was compared using a Mouse Genome Oligo Set Version 3.0 (Qiagen-Operon) 70mer-oligonucleotide array. Results from microarray analysis were analyzed using the GeneSpring bioinformatics program. The microarray results were further confirmed by real-time PCR. Mice were made vitamin A deficient by placing them on the modified AIN-93G diet without vitamin A on the tenth day of gestation. Both the differential expression of metabolic genes and the metabolic outcome of this differential expression were assessed. ^ In this study, vitamin A deficiency caused a decrease in expression of genes encoding enzymes involved in mitochondrial β-oxidation, including fatty acid ligase, medium-chain acyl-CoA dehydrogenase, 3,2-trans-enoyl-CoA isomerase and carnitine o-palmitoyl transferase I in the liver. A decrease in the mitochondrial β

Full Text - Objective: The current study evaluated the relationship between circulating fat soluble vitamin status and cognition in aging Chinese population.Methods: A cross-sectional study was carried out in 1754 community residents aged 55-80 years aiming to evaluate the relationship between circulating α-tocopherol and retinol status and cognition. The effect of ApoE genetic polymorphism on the relationship between vitamins and cognition was also explored.Results: Our results indicated that serum retinol status positively correlated with cognitive performance; while, serum α-tocopherol (α-TOH)/retinol ratio negatively correlated with cognitive performance. Mild cognitive impairment (MCI) subject demonstrated higher serum α-TOH status (P < 0.05), α-TOH/retinol ratio (P < 0.01) and lower retinol status (P < 0.01) than normal subjects. Subjects with ApoE4 genotype have lower serum retinol level (P < 0.05) and higher α-TOH/retinol ratio (P < 0.01)

Golden rice is rich in vitamin A. Rice kernals are deficient of vitamin A ,so people who obtain most of their calories from rice are deficient of vitamin A..

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Vitamin A deficiency, which affects about 100 million young children worldwide, was long known to cause blindness. But it has become increasingly clear that even mild vitamin A deficiency also impairs the immune system, reducing childrens resistance to diarrhoea, which kills 2.2 million children a year, and measles, which kills nearly 1 million annually. And new findings strongly suggest that vitamin A deficiency is a cause of maternal mortality as well, especially among women in impoverished regions (Panel 1).. At its most basic level, malnutrition is a consequence of disease and inadequate dietary intake, which usually occur in a debilitating and often lethal combination. But many more elements -- social, political, economic, cultural -- are involved beyond the physiological.. Discrimination and violence against women are major causes of malnutrition.. Women are the principal providers of nourishment during the most crucial periods of childrens development, but the caring practices vital to ...

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Youve all probably heard the idea that stress causes health problems. Your doctor may have even told you that your health concern(s) exist solely because of stress. In my opinion - thats pretty close to nonsense. Its a great excuse though. Why? Stress doesnt cause poor health. OK, Ill be flexible with you. Severe, unrelenting physical (major accident, etc.), chemical (acute exposure to a massive dose of a toxin, etc.) or emotional ((un)expected death, etc.) stressors can actually cause health problems. Im also willing to say that long-term unresolved stressors can also cause health problems. But then again, its not necessarily the stress thats causing the problem if its that long-term (referring to behavioral patterns). There could be an emotional component to why the long-term stressor has not been resolved. Either way, those instances are fortunately not the norm. With that in mind, I find most of the time its not the stressor that is the problem, its how the body handles the ...

I have gained a bit of weight (yay!! mostly fluids - but there is some real weight in there too we think!), and the massive doses of IV steroids they had to use to treat the allergic reactions (basically it would start as a few red marks around the dressing, and within hours I was completely covered in hives and my mouth was going numb - it was dramatic!!) have actually stirred my gut up a bit and Ive been able to tolerate some tube feeds, and some oral food! Nowhere near enough to go off TPN or even really cut back much, and I cannot drink enough to stay hydrated, but its a very small improvement - after nothing but decline, a very small improvement is welcome ...

Well kids, I am very tired today, due to a massive dose of antihistamines the last couple of days. Dont ask. Anyway since utenzi tagged me, I will try to think of a few movies for you to munch on, in semi-chronological order of when I saw them and liked them. I dont necessarily still like all of these as much as I did then, not by a long shot. And Im sure some anal-retentive person will correct me if I list them in the wrong order of when they were made ...

Impression cytology is fast, easy to perform, economical and noninvasive technique for the diagnosis of conjunctival eye diseases. Conjunctival impression cytology using cellulose acetate filter paper of the ocular surface epithelium with no side effects or contraindication. In this article, technique of conjunctival impression cytology is reviewed ...

TY - JOUR. T1 - Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. AU - Wang, Y.. AU - Zolfaghari, R.. AU - Catharine, Ross A.. PY - 2002/5/15. Y1 - 2002/5/15. N2 - A novel retinoic acid (RA)-inducible cytochrome P450 (P450 RAI or CYP26), previously cloned from human, zebra fish, and mouse, functions in the metabolism of all-trans-RA to polar metabolites including 4-hydroxy-RA and 4-oxo-RA. To further study CYP26 in the rat model, we first cloned rat CYP26 cDNA. The nucleotide sequence predicts a 497-amino-acid protein whose sequence is 95% identical to mouse and 91% homologous to human CYP26. Animal studies showed that CYP26 mRNA expression is very low (0.01 ± 0.008; P , 0.05) in vitamin-A-deficient rats compared to pair-fed vitamin-A-sufficient rats (defined as 1.0). In a kinetic study, vitamin-A-deficient rats were treated with ∼ 100 μg of all-trans-RA and liver was collected after 3-72 h for analysis of CYP26 mRNA by ...

This blinded randomised trial has shown that oral supplementation of vitamin A in a dose of 5000 IU/day did result in an increase in plasma retinol concentrations but did not decrease the incidence of CLD in preterm infants of less than 1000 g birth weight. In addition, mortality and the incidence of other complications such as ROP, IVH, NEC, and PDA were unaffected by vitamin A supplementation. The results of this study of oral supplementation are in contrast with previous studies, which used intramuscular supplementation of vitamin A and showed a significant decrease in the incidence of oxygen dependency at 1 month of age and/or death.6-12 Although most of these studies were performed before the routine use of antenatal steroids and postnatal surfactant, the most recent study was performed after the introduction of these important interventions, which may influence the incidence of CLD.6 This study is the first randomised controlled trial of oral vitamin A supplementation, and it has been ...

Hi everyone! This is Jeffery Smith and Im reporting on the news development that the Department of Agriculture in the Philippines has approved genetically engineered golden rice to be, As safe as conventional rice. . What a disaster this is! This is incredible! Now, a lot of people think that golden rice is the example of why we should be allowing genetically engineered foods into the diet because its designed to provide vitamin A for vitamin A-deficient children who are suffering from blindness and death. On the cover of TIME magazine, they say This rise could save the lives and health of, you know, thousands or millions of children each year. Well, this is all false hype. Lets go through this and find out the truth behind GE golden rice. First of all, rice is a staple in parts of Asia and other places. So we are considering genetically engineering something that will be eaten three times a day. If theres any health issue associated with it, it could be a disaster. Now, the Philippines ...

As a result, the edible part of rice grains consists of the endosperm, filled with starch granules and protein bodies, but it lacks several essential nutrients for the maintenance of health, such as carotenoid… a) Insect resistance b) High protein content c) High vitamin A content d) High lysine content Answer: c) High vitamin A content 2. Answer: (a) RNAi only 46 Over the years the contribution of agriculture to Indian GDP is . (a) acidic pH of stomach (d) To produce useful biological products In which of the following states, is rice … Rice is a subsistence crop in Orissa. Some topics that you will be assessed on include the nutrients in golden rice and the problems associated with vitamin A deficiency. (b) Oryza Golden rice is a new variety of rice which has very high Vitamin A content. #Golden rice is rich in (a) Vit.C (b) Vit.D (c) Vit.E (d) Vit.A #More for Less slogan of SRI belongs to which state (a) Tripura (b) Nagaland (c) Punjab (d) Tamil Nadu. Biological and Biomedical Rice is ...

The results of various studies show severe Vitamin D deficiency across India and Pakistan in all age groups, as well as insufficiency in populations of South-East and East Asia.

Vitamin A palmitate 1.5MIU/g is the Corrective Vitamin otherwise known as Retinol Palmitate or Retinyl Palmitate. Retinyl palmitate can be used as an additive in skin care formulations or can be applied directly onto the skin. After its absorption into the skin, retinyl palmitate is converted to retinol, and ultimately to retinoic acid (the active form of vitamin A present in Retin-A). Only retinoids such as retinoic acid have a direct effect on skin and can adjust to help the skin achieve a more youthful look.. ...

The third goal specified in the contract is perhaps the most important. It addresses the important planning question of what we should expect in a new programme in a new setting. The response can be divided into two sub-questions: in what population setting(s) can one expect vitamin A to be effective and what is the range of effect to be expected?. Where is improvement of vitamin A status most likely to affect morbidity and mortality?. The obvious answer to this question is: Where vitamin A deficiency is now a serious problem. For the mortality trials, all of which were conducted in settings where it was assumed vitamin A was a public health problem under the WHO definition, we attempted to ask about population-level predictors of the relative effect. Statistical power was very low for these analyses of the predictors of response (mortality of control group, xerophthalmia, stunting, wasting) since study was the unit of analysis (n = 8). Individual-level data might have uncovered more subtle ...

Subclinical vitamin B-12 deficiency is common in the elderly. Encouraged by early indications, we investigated the plasma vitamin B-12 status in association with bone mineral content (BMC) and bone mineral density (BMD) in frail elderly people. Data of 194 free-living Dutch frail elderly (143 women and 51 men) were available. BMC and BMD were ...

The World Health Organization estimates that Vitamin A deficiency causes 500,000 cases of child blindness a year, and 6,000 deaths. Five years ago, it was claimed that genetic engineering could help solve this problem with

Retinol. Molecular model of the diterpenoid alcohol retinol (C20.H30.O), one of the forms of vitamin A. This chemical, when converted to the retinal form, is vital to the functioning of the eyes retina. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white) and oxygen (red). Illustration. - Stock Image F017/0736

Im not totally against Jamies desire to shift people towards a more wholesome diet, but his demonisation of sugar in drinks whilst continuing to sell sweet desserts ironically leaves me with a bitter taste in my mouth. As Ive stated before, sugar is neither toxic (unless consumed in massive doses, which applies to most substances) or addictive. It is essential, (especially for brain function it would appear) and pretty disgusting if consumed alone (take the sugar challenge and see how many spoonfuls of table sugar you want to consume). I admit that when food processors get their hands on sugar and fat they are able to induce sometimes uncontrollable cravings, but as a chef surely that is Jamies role? To create dishes that entice our tastebuds and leave us desiring more ...

Im not totally against Jamies desire to shift people towards a more wholesome diet, but his demonisation of sugar in drinks whilst continuing to sell sweet desserts ironically leaves me with a bitter taste in my mouth. As Ive stated before, sugar is neither toxic (unless consumed in massive doses, which applies to most substances) or addictive. It is essential, (especially for brain function it would appear) and pretty disgusting if consumed alone (take the sugar challenge and see how many spoonfuls of table sugar you want to consume). I admit that when food processors get their hands on sugar and fat they are able to induce sometimes uncontrollable cravings, but as a chef surely that is Jamies role? To create dishes that entice our tastebuds and leave us desiring more ...

Ophthalmic compositions having negligible side effects on the heart can be obtained by using as the active ingredient an adrenergic β receptor agonist having a high selectivity toward adrenergic β2 receptor. These compositions are usable as preventives or therapeutics for xerophthalmic disorder and keratoconjunctival disorder.

Material Weakness or Significant Deficiency. The difference between a material weakness and a significant deficiency is simply that a significant deficiency is less severe. A significant deficiency is, however, still risky enough for the auditor to let management know so that they may have a chance to get rid of the problem.

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Vitamin A-deficient (A-) mice make strikingly poor IgG responses when they are immunized with purified protein antigens. Previously, we showed that A- T cells overproduce interferon gamma (IFN-gamma), which then could inhibit interleukin 4 (IL-4)-stimulated B cell IgG responses. To determine if the altered IFN-gamma regulation pattern and its immunological consequences would extend to a natural infection, we studied mice infected with the parasitic helminth Trichinella spiralis. The course of the infection was similar in A- and A-sufficient (A+) mice. These mice did not differ with respect to newborn larvae/female/hour produced in the intestine, or muscle larvae burden 5 wk postinfection. They also did not differ in the intestinal worm expulsion rate until day 15, when A- mice still harbored parasites, whereas A+ mice had cleared intestinal worms. Vitamin A deficiency reduced both the frequency of B lymphocytes secreting IgG1 antibodies to parasite antigens, and the bone marrow eosinophilia ...

Degradation of beta-carotene during storage is a problem that may prove even more troublesome for the proposed nutritional benefits of Golden Rice than its initial low levels.. Unnoticed by the media, a 2017 paper published in the Journal of Agricultural and Food Chemistry reported that the beta-carotene content of Golden Rice GR2E at harvest is short-lived (Schaub et al. 2017).. This study found Golden Rice retained only 60% of its original beta-carotene levels after 3 weeks of storage and just 13% after 10 weeks.. The apparent explanation is that the beta-carotene in Golden Rice is unstable in the presence of oxygen. Thus, under normal storage conditions, the beta-carotene in Golden Rice grains will rapidly degrade.. Under tropical farming, storage, and household conditions, degradation may be faster still.. In any event, the low levels and rapid degradation of beta-carotene measured in Golden Rice GR2E seem a significant blow to the likelihood that Golden Rice will fulfill expectations. That ...

If these strategies do not work, poor vitamin A status should be considered a possible explanation. This interpretation is strengthened if you have poor night vision (for example, if you strain your eyes or have trouble seeing when driving down an unlit road with your headlights alone but can see fine without any eyestrain during the day) or dry eyes. This interpretation is also strengthened if you have serum retinol near or below the bottom of the reference range, or if you track your vitamin A intake and your daily average is below the RDA.. It is important to note that any of these additional pieces of evidence strengthen the interpretation of poor vitamin A status, but their absence does not rule it out. If circadian rhythm disruption is more sensitive to deficiency than night blindness, then it may occur in the absence of other clinical signs, at serum retinol concentrations within the reference range, and at vitamin A intakes above the RDA.. The best way to ensure basic adequacy of vitamin ...

TY - JOUR. T1 - Urinary excretion of retinol in children with acute diarrhea. AU - Alvarez, J. O.. AU - Salazar-Lindo, E.. AU - Kohatsu, J.. AU - Miranda, P.. AU - Stephensen, C. B.. PY - 1995. Y1 - 1995. N2 - Acute infections of childhood are associated with an increased rate of xerophthalmia, apparently due to depletion of vitamin A stores. The mechanism responsible for this is not known. Recently, it has been reported that severe infections in adult patients (ie, sepsis and pneumonia) result in excretion of large quantities of retinol in the urine. In 44 children hospitalized for treatment of acute diarrhea we found mean urinary excretions of 1.44 μmol retinol/24 h on day 1 of hospitalization, 0.62 μmol retinol/24 h on day 2, and 0.23 μmol/24 h on day 3. Healthy control subjects matched for age did not excrete measurable amounts of retinol in the urine. Retinol excretion was associated strongly with rotavirus diarrhea and presence of fever. Furthermore, serum retinol concentration was ...

Thus, predominant rice consumption promotes vitamin A deficiency, a serious public health problem in at least 26 countries, Instead, they very much. The golden rice case hopefully may help to, the support of the public. And they need Vitamin M, thats Vitamin Money. Investigation of the biochemical properties of immature rice endosperm using [14C]-labelled substrates revealed the presence of geranyl geranyl diphosphate, the C20 general isoprenoid precursor necessary for C40 carotenoid biosynthesis. At that time I was much, tempted to join those who fight patenting. You will argue t, might be able to help solve the problem of vitamin A, Board is chaired by Ingo Potrykus, the co-inventor of golden, further golden rice research and the introduction of golden rice. Each team will be given a list of facts on golden rice. Accordingly you will argue against continued. Critics have countered that the rice is a hoax, that it is fools gold and propaganda for the genetic engineering industry. One ...

Amy Skversky, M.D., M.S.When doctors write that prescription for steroids and theyre sending the patients for lab tests, they should also get the vitamin D level measured, said study lead author Amy Skversky, M.D., M.S., assistant professor of pediatrics at Einstein and Montefiore Medical Center, the University Hospital for Einstein.. The severe vitamin D deficiency assessed in this study (defined as levels below 10 nanograms per milliliter of blood) is known to be associated with osteomalacia (softening of the bones), rickets (softening of bones in children) and clinical myopathy (muscle weakness). While there is much debate on the issue, vitamin D levels between 20 and 50 ng/ml are generally considered adequate for bone and overall health in healthy individuals. Steroids have been shown to cause vitamin D deficiency, possibly by increasing levels of an enzyme that inactivates the vitamin.. Smaller studies involving people often prescribed steroids (i.e., children with asthma and patients ...

Purpose:To identify children aged 0-72 months with blinding xerophthalmia in the North West Frontier Province (NWFP) and its adjoining Federally Administered Tribal Areas (FATA) in Pakistan, using a new surveillance system, and to describe socio-economic and other characteristics of reported cases. Methods: All ophthalmologists in district headquarter hospitals in NWFP and agency headquarter hospitals in FATA were requested to participate in a surveillance programme for the detection of blinding xerophthalmia (corneal xerosis, corneal ulcers, keratomalacia and corneal scars related to vitamin A deficiency) for children aged 0-72 months. The surveillance included reporting of each case of blinding xerophthalmia presenting to the participating eye units over a period of 12 months and recording their socio-economic and other related characteristics. Results: Seventy six cases of blinding xerophthalmia were reported and there was almost no gender difference. Children came from 19 of 31 districts and

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a. Number of cases.. Vitamin-A deficiency (xerophthalmia and keratomalacia). Untreated vitamin-A deficiency leads to irreversible blindness and death. Growing children are at the greatest risk of developing signs of xerophthalmia because of their higher vitamin-A requirement and also because they have a higher rate of infections. A close association between even moderate vitamin-A deficiency and increased morbidity and mortality from respiratory and gastro-intestinal infections has been reported [8].. The lead time for the signs to develop depends on the level of vitamin A stored in the body. Refugees most often arrive in camps with low vitamin-A stores after subsisting on a deficient diet prior to and during their exodus, and during initial periods in the country of asylum. Thus, the lead time for developing xerophthalmia in refugees can be expected to be shorter than in a population that suffers vitamin-A deficiency without previous malnutrition.. Iron deficiency (anaemia). Anaemia can have ...

SUMMARY : GOLDEN RICE One of the applications of recombinant DNA technology in enriched foods field is golden rice. The organism used is daffodil or maize

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Several studies have shown that klf2 activates the expression of vascular genes including endothelial NO synthase (eNOS).16,30,34 NO is involved in several physiologic and pathologic events. In particular, NO produced by the eNOS is a fundamental determinant of cardiovascular homeostasis, including systemic blood pressure, vascular remodeling, and angiogenesis.35 In cultured endothelial cells, shear stress and other factors have been shown to increase eNOS expression.36 To determine whether NO signaling was altered in tnnt2a- and klf2a-deficient embryos, we first used NO imaging to visualize NO production in live embryos. DAF-FM staining showed that NO production was reduced in the tnnt2a- and klf2a-deficient embryos (Figure 7B-C red arrows), compared with that in controls. To further test whether NO signaling was involved in the blood flow response required for HSC development, we examined nos1 and nos2a/2b expression in klf2a-deficient embryos. nos1 and nos2b expression was significantly ...

The use of psychotropic prescription medications to treat mental health disorders in very young children is stabilizing, according to a study published in

Among the most underrated areas of fitness is that great nights sleep! If you arent well-rested do you expect to get lively and motivated the following moment, enough to your work out? Additionally, it is understood by a lot of people which you really burn calories while sleeping, actually more than you do watching tv! Not many multivitamins are made equal. Consequently, youre ensuring that youre receiving all the crucial nutrients you ought to be receiving out of a multivitamin. Occasionally, our fiscal condition keeps us from eating correctly. Vitamins and antioxidants help to eliminate all the toxins inside the body. Its unsafe to take more than the suggested price of the majority of vitamins, so be certain you avoid that. 1 case of that is iron, which is Codeage Exogenous Ketones Capsules Customer Reviews harmful to the liver if taken in massive doses. Should you really feel as if you arent receiving the best benefit from the vitamins, you should probably consult with a dietician about ...

A verified doctor answered: No: Not to my knowledge unless your joint pain is dues to some specific severe vitamin deficiency sy...

Vitamin A deficiency is occasionally seen in chickens and turkeys (insufficient vitamin A during 1-7 weeks of age). As in the case of other nutritional deficiencies, classic signs of deficiency are very rare in commercial poultry fed complete diets ...

When my 83-year-old mom-in-law was dying of bowel cancer, her doctor could not use the D word with her, either.. Somehow, she was under the impression that all these last ditch efforts they were making-the massive doses of antibiotics to hold back her pneumonia, the surgery to insert a shunt to because her kidneys were failing-well, she thought all these things were done because there was hope. Thing was, hope had left the building a month ago. The cancer had spread to her kidneys. It was a race between the kidney cancer and the pneumonia. Her kidneys quit first. Her doctor was straight with us, but not with her.. When her doctor finally screwed up the courage to tell her that she was in palliative care, that nothing more could be done, she made her peace with dying, said her good-byes, lapsed into a coma and died peacefully within 36 hours.. I have seen three parents through palliative care for cancer now-my father, my dad-in-law and my mom-in-law. The doctors were quite forthcoming with both ...

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Few plant species can have been better studied than rice. There is a wealth of information out there; Ive picked a few interesting and enlightening extracts- a résumé of rice if you like.. ...

There are 16 fourteen-letter words containing A, H, M, T and X: ANTIHOMOSEXUAL CHEMOTAXONOMIC DEXAMETHASONES ... XANTHOCHROMIAS XANTHOMELANOUS XEROPHTHALMIAS. Every word on this site is valid scrabble words. See other lists, beginning with or ending with letters of your choice.

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The idea of a link between inadequate vitamin A and hearing disorders was initially treated with suspicion, reflected by its being confined to animal studies and observations

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