TY - JOUR. T1 - Neutralisation of local haemorrhage induced by the saw-scaled viper Echis carinatus sochureki venom using ethanolic extract of Hibiscus aethiopicus L.. AU - Hasson, S. S.. AU - Al-Balushi, M. S.. AU - Said, E. A.. AU - Habbal, O.. AU - Idris, M. A.. AU - Mothana, R. A A. AU - Sallam, T. A.. AU - Al-Jabri, A. A.. PY - 2012. Y1 - 2012. N2 - The objective of the study is to investigate the anti-snake venom activities of a local plant, Hibiscus aethiopicus L. The H. aethiopicus was dried and extracted with ethanol. Different assays were performed according to standard techniques, to evaluate the plants acute toxicity and its antivenom activities. The results of evaluating the systemic acute toxicity of the H. aethiopicus extract using "oral and intra-peritoneal" route were normal even at the highest dose (24g/kg) tested. All guinea pigs (n=3) when treated with venoms E. c. sochureki (75g) alone induced acute skin haemorrhage. In contrast, all guinea pigs (n=18) treated with both ...
Based on our results, we hypothesize that within the family Viperidae, the ability to use thermal radiation to mediate thermoregulatory decisions is unique to pitvipers and might have arisen concurrently with the facial pits. However, this apparent phylogenetic pattern must be interpreted conservatively, as we only surveyed a single species of true viper and we did not examine Azemiops feae, the purported sister taxon to the pitvipers (Parkinson et al., 2002). The range of species studied needs to be expanded significantly to test this hypothesis fully.. The ability to mediate behavioral thermoregulation using only thermal radiation as a cue appears to be an ancestral trait among pitvipers. The simple phylogenetic and ecological presence or absence pattern that we found indicates that the use of thermal radiation cues to direct thermoregulatory movements arose very early in the history of pitvipers. As this behavior was absent in the only true viper studied, it is possible that this behavior ...
Secretory phospholipasesA2 (sPLA2s) form a large family of structurally related enzymes widespread in nature. Herein, we studied the inhibitory effects of sPLA2s from Vipera lebetina (VLPLA2), Vipera berus berus (VBBPLA2), and Naja naja oxiana (NNOPLA2) venoms on (i) human platelets, (ii) four different bacterial strains (gram-negative Escherichia coli and Vibrio fischeri; gram-positive Staphylococcus aureus and Bacillus subtilis) and (iii) five types of cancer cells (PC-3, LNCaP, MCF-7, K-562 and B16-F10) in vitro. sPLA2s inhibited collagen-induced platelet aggregation: VBBPLA2 IC50 = 0.054, VLPLA2 IC50 = 0.072, NNOPLA2 IC50 = 0.814 μM. p-Bromophenacylbromide-inhibited sPLA2 had no inhibitory action on platelets. 36.17 μM VBBPLA2 completely inhibited the growth of gram-positive Bacillus subtilis whereas no growth inhibition was observed towards gram-negative Escherichia coli. The inhibitory action of sPLA2s (~0.7 μM and ~7 μM) towards cancer cells depended on both venom and cell type. VBBPLA2
Hemorrhage is the most potent manifestation of envenomation by Vipera ammodytes ammodytes (V. a. ammodytes) venom in man. A detailed description of the venom components contributing to this effect is thus medically very important. We have characterized a novel component, termed here VaH3, as a potently hemorrhagic snake venom metalloproteinase (SVMP). Its proteolytic activity and overall stability depend on the presence of Zn(2+) and Ca(2+) ions. The molecular mass of this slightly acidic molecule, determined by MALDI/TOF analysis, is 104 kDa. Chemical reduction and S-carbamoylmethylation result in a single monomer of 53.7 kDa. N-deglycosylation decreased this mass by 4.6 kDa. The complete amino acid sequence of VaH3 was determined by protein and cDNA sequencing, showing that each of the identical glycoprotein subunits comprise a metalloproteinase, a disintegrin-like domain and a cysteine-rich domain, VaH3 belongs to the P-IIIc class of SVMPs. It shows strong sequence similarity to vascular endothelial
Synonyms for Cobra gabonica in Free Thesaurus. Antonyms for Cobra gabonica. 1 synonym for Bitis gabonica: gaboon viper. What are synonyms for Cobra gabonica?
The gaboon viper is a venomous snake living in central Africa. These snakes have an amazing pattern on their backs, comprised mostly of various sizes, shapes, and colors of triangles. Their scales can be olive green, black, white, gray, and different shades of brown. These earthy colors help the gaboon viper camouflage with the leaves on the forest floor.. The picture below shows a close-up of a this snakes head. The first thing to notice is the red arrows pointing to the bulges on either side of the snakes head. These bulges, which make the head triangular, are the venom sacks where the venom is stored. At the tip of the snakes nose, you can see two small horns close together. These can be used to distinguish these snakes from most others. Below the horns are the snakes nostrils, which help them detect prey.. ...
Taxonomic database that provides basic information about all living reptile species, such as turtles, snakes, lizards, and crocodiles, as well as tuataras and amphisbaenians, but does not include dinosaurs.
Taxonomic database that provides basic information about all living reptile species, such as turtles, snakes, lizards, and crocodiles, as well as tuataras and amphisbaenians, but does not include dinosaurs.
Medically important cases of snakebite in Europe are predominately caused by European vipers of the genus Vipera. The mainstay of snakebite therapy is polyclonal antibody therapy, referred to as antivenom. Here we investigate the capability of the monospecific V. berus antivenom, ViperaTAb®, to cross-react with, and neutralise lethality induced by, a variety of European vipers. Using ELISA and immunoblotting, we find that ViperaTAb® antibodies recognise and bind to the majority of toxic components found in the venoms of the Vipera species tested at comparably high levels to those observed with V. berus. Using in vivo pre-clinical efficacy studies, we demonstrate that ViperaTAb® effectively neutralises lethality induced by V. berus, V. aspis, V. ammodytes and V. latastei venoms and at much higher levels than those outlined by regulatory pharmacopoeial guidelines. Notably, venom neutralisation was found to be superior to (V. berus, V. aspis and V. latastei), or as equally effective as (V. ammodytes),
Geniez, P. and Tynié, A. 2005. Discovery of a population of the critically endangered Vipera darevskii Vedmederja, Orlov & Tuniyev, 1986 in Turkey, with new elements on its identification (Reptilia: Squamata: Viperidae). Herpetozoa 18(1-2): 25-33.. IUCN. 2009. IUCN Red List of Threatened Species (ver. 2009.1). Available at: www.iucnredlist.org. (Accessed: 22 June 2009).. Nilson, G., Tuniyev, B., Andrén, C. and Orlov, N. 1999. Vipers of Caucasus: Taxonomic considerations. Kaupia (Darmstadt): 103-106.. Orlov, N.L. and Tuniyev, B.S. 1990. Three Species in the Vipera kaznakowi Complex (Eurosiberian Group) in the Caucasus: Their Present Distribution, Possile Genesis, and Phylogeny. Asiatic Herpetological Research: 1-36.. Vedmederja, V., Orlov, N.L. and Tuniev, B., 1986. On taxonomy of three vipers species of the Vipera kaznakovi complex. Proc. Zool. Inst.Lelingr.: 265-271.. ...
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pp. 237-246Authors: Guo, Peng; Malhotra, Anita; Li, Pi P.; Pook, Catharine E. & Creer, SimonAbstract: Although much systematic wor...
For me, its Calloselasma rhodostoma. The Malayan Pit Viper.. In a video, Al Coritz, AKA: Viperkeeper, on YouTube said hed rather take a bite from one of the mambas than this same snake. No really, he said it. Its here at 1 min. 37 secs. Have a look: https://www.youtube.com/watch?v=-fVDZ2N2GLk. So, what is it about this snake that strikes such fear into people?. Its the total devastation the venom from this snake causes at the bite site and across the organs of the body.. The venom immediately starts destroying skin tissue, blood, connective tissue of all sorts, muscle, and even bone. It actually destroys bone. Thats strong venom!. Then, the anti-coagulant properties cause the bitten victim to bleed from all over the body. Blood may be seen coming out of the mouth, gums, nose, eyes, ears, anus, and urethra, not to mention the bite site.. Bleeding can be going on unseen in the brain - causing death in some cases.. Its a horrible thing to go through. If bitten and the wound is burning, you ...
VenomousReptiles.org Article: Lachesis Bites in Brazil: 2 Cases - |i|If there is venom inoculation, the first 60 minutes of these accidents are always dramatic and similar to the evolution of the hypovolemic shock: severe hypotension may occur within 20 minutes...|/i| - VenomousReptiles.org - The SHHS is a group of venomous reptile keepers educating the public about venomous snakes and lizards. Here you will find everything you ever wanted to know about rattlesnakes, cottonmouths, copperheads, king cobras and even the notorious black mamba. Everyone is welcome!
Last Saturday (30 March 2009)night, went to Sungei Buloh Wetland Reserve for a night survey on Spiders. Because of raining, we were taking shelter at the Main Hide. Many of terrestrial animals "followed" us to take a shelter, including a mangrove pit viper and few caterpillars. One of the caterpillar was dropping on the back of the snake from the wooden wall when I was shooting the Pit Viper, and caused the snake to react badly. I was shock when I saw this through the camera and the snake, all of a sudden, shaking his head strongly and that cause me almost to drop my camera ...
The snake is the second most deadly animal in the world. It kills approximately 50,000 people every year. Already though you can see how terrible the mosquito is at it kills 14 times more people every single year. The snake is a puppy in comparison.. There are many types of snakes with various levels of venom that are responsible for the 50,000 murders. The most deadly snake is the saw-scaled viper. It is low on the venom chart but it kills over 5,000 people each year. It manages to kill this many because it is very prevalent in highly populated areas. Other snakes that have more venom, like the Inland Taipan can kill a human in 45 minutes but it is low on the death figures because it rarely bites humans.. ...
The surucucú is a venomous viper (Lachesis muta), also known as the shushúpe in Peru, or Bushmaster in English, that is highly aggressive. Not only is its venom deadly, the surucucú will bite you multiple times, and is even known to chase people.. If you are bitten and dont get the antivenom within a couple of hours, you will die. A friend of mine was bit by a shushupe when she worked for an eco-lodge in the Iquitos area. They rushed her to Iquitos by high-speed motorboat, but it took an hour for her to reach the city. When she got to the hospital, she was bleeding out of her eyes, ears, mouth and fingernails. It took her a month to recover, and her health has been fragile ever since.. The best defense against surucucús are knee high rubber boots and being mindful of where you are stepping. They like to hide in the spaces under tree roots, especially cavities under tree roots that are covered by leaves. If you are stepping over a large root, try to look over it to see whats on the other ...
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Predĺžená miecha sa akoby skladá z dvoch častí: otvorenej (bližšie k mostu), a uzavretej (nižšia časť naväzujúca na miechu). Otvorenie sa vzťahuje k zadnej časti predĺženej miechy, ktorá tvory časť spodiny IV. mozgovej komory. Z miechy v nej pokračuje canalis centralis, ktorý sa tu rozširuje a plynulo prechádza do IV.mozgovej komory. Prednú stenu predĺženej miechy tvoria dva symetrické pozdĺžne prebiehajúce valy - pyramídy predĺženej miechy (lat. pyramides medullae oblongatae), ktoré obsahujú vlákna motorických (riadiacich pohyb), tzv. pyramídových dráh. Medzi nimi sa v strednej čiare nachádza zárez, ktorý plynule prechádza z miechy a nazýva sa fissura mediana anterior. Tento zárez je v mieste spojenia miechy a predĺženej miechy prerušený nápadným krížením pyramídových dráh - decussatio pyramidum. Ne prednej strane kraniálne medulla oblongata končí ryhou, ktorú vytvára naprieč uložený val Varolovho mosta - sulcus ...
Predĺžená miecha sa akoby skladá z dvoch častí: otvorenej (bližšie k mostu), a uzavretej (nižšia časť naväzujúca na miechu). Otvorenie sa vzťahuje k zadnej časti predĺženej miechy, ktorá tvory časť spodiny IV. mozgovej komory. Z miechy v nej pokračuje canalis centralis, ktorý sa tu rozširuje a plynulo prechádza do IV.mozgovej komory. Prednú stenu predĺženej miechy tvoria dva symetrické pozdĺžne prebiehajúce valy - pyramídy predĺženej miechy (lat. pyramides medullae oblongatae), ktoré obsahujú vlákna motorických (riadiacich pohyb), tzv. pyramídových dráh. Medzi nimi sa v strednej čiare nachádza zárez, ktorý plynule prechádza z miechy a nazýva sa fissura mediana anterior. Tento zárez je v mieste spojenia miechy a predĺženej miechy prerušený nápadným krížením pyramídových dráh - decussatio pyramidum. Ne prednej strane kraniálne medulla oblongata končí ryhou, ktorú vytvára naprieč uložený val Varolovho mosta - sulcus ...
Synonyms for Ammodyte in Free Thesaurus. Antonyms for Ammodyte. 1 synonym for Ammodytes: genus Ammodytes. What are synonyms for Ammodyte?
Yesterday I read a fascinating (to me, anyway) article about the history of the development of drugs to treat hypertension (high blood pressure). The topic is interesting to me because a couple of months ago, my blood pressure inexplicably went from Too high to Be prepared to die. For just over a month now, Ive…
La dopamina (DA) estimula el factor liberador de hormona luteinizante (LHR), incrementa la hormona luteinizante (LH) e induce ovulaci n. El precursor inmediato, la L-dopa, ha sido usado para inducir la ovulaci n y en el s ndrome amenorrea-galactorrea, pero esta droga produce varios efectos indeseables. Por esta raz n pareci conveniente investigar drogas capaces de elevar la DA cerebral con menos efectos colaterales. La acci n del veneno de la serpiente Lachesis trigonocephalus sobre la DA cerebral fue estudiada en ratas Wistar. Treinta y nueve animales recibieron el veneno a una dinamizaci n de 1 x 10-24 = 12CH en etanol al 22.5%. La droga fue administrada per os con un cat ter a la dosis de 0.25 ml, con intervalos de 8 horas, durante 10 d as. Treinta y tres ratas sirvieron como controles y recibieron la misma dosis de etanol sin la droga. El grupo control mostr un nivel medio de 998 43 ng/g (X SE) y los animales que recibieron la droga 1136 57 ng/g (P < 0.05). La concentraci n de noradrenalina ...
Relative proportion of each category of product found in M. corallinus venom gland transcriptome. Toxin, Non-toxin and No Hit categories are, respectively, clus
Species: L. astricta - L. cerastes - L. cnestovalva - L. competitrix - L. diclada - L. docillis - L. exocha - L. ficta - L. gravida - L. guanana - L. heterophaea - L. ichthyochroa - L. ilingocornuta - L. limatula - L. luminosa - L. megapenis - L. micida - L. omissa - L. perlochra - L. pervicax - L. puertoricana - L. revulsa - L. sorbia - L. subdiclada - L. subsorbia - L. taima - L. tardans. Name. Lasiothyris Meyrick, 1917. Type species: Lasiothyris limatula Meyrick, 1917.. Synonyms. * Lasithyris Obraztsov, 1967, J. New York ent. Soc. 75: 7. [misspelling of Lasiothyris]. ...
The objective of this study was to investigate the in vitro effect of Vipera lebetina venom on human erythrocytes osmotic fragility with respect to differ...
Cerastotin, a thrombin-like enzyme from the venom of the desert viper Cerastes cerastes, has been purified by gel filtration on Sephadex G-75 and two ion-exchange chromatographies on Mono S columns. It is a neutral glycoprotein (pI = 6.6), present as a single polypeptide chain of 40 kDa. Its N-terminal sequence shows strong similarity with those of other thrombin-like enzymes from snake venoms. Cerastotin possesses esterase and amidolytic activities measured with N(alpha)-tosyl-L-arginine methyl ester and the thrombin chromogenic substrate D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide, respectively. The amidolytic activity is inhibited by phenylmethylsulfonyl fluoride, N(alpha)-tosyl-L-lysine chloromethane, N(alpha)-tosyl-L-phenylalanyl chloromethane, D-phenylalanyl-L-prolyl-L-arginyl chloromethane and benzamidine, suggesting that cerastotin is a serine protease. Cerastotin efficiently clots human plasma and cleaves preferentially the alpha chain of fibrinogen. Cerastotin did not induce
Looking for online definition of Cobra lachesis in the Medical Dictionary? Cobra lachesis explanation free. What is Cobra lachesis? Meaning of Cobra lachesis medical term. What does Cobra lachesis mean?
Evidence from numerous Pan-African savannah mammals indicates that open-habitat refugia existed in Africa during the Pleistocene, isolated by expanding tropical forests during warm and humid interglacial periods. However, comparative data from other taxonomic groups are currently lacking. We present a phylogeographic investigation of the African puff adder (Bitis arietans), a snake that occurs in open-habitat formations throughout sub-Saharan Africa. Multiple parapatric mitochondrial clades occur across the current distribution of B. arietans, including a widespread southern African clade that is subdivided into four separate clades. We investigated the historical processes responsible for generating these phylogeographic patterns in southern Africa using species distribution modelling and genetic approaches. Our results show that interior regions of South Africa became largely inhospitable for B. arietans during glacial maxima, whereas coastal and more northerly areas remained habitable. This ...
It is not clear that ARF results from a direct cytotoxic effect on renal epithelia or from a renal ischemia due to systemic hemodynamic disturbances. This work investigated the in vitro effect of Echis Carinatus crude venom, using cultured Human embryonic kidney (HEK 293) mono layers as a model to see the cytotoxic effect of Echis carinatus venom.
The snake venom gland is a specialized organ, which synthesizes and secretes the complex and abundant toxin proteins. Though gene expression in the snake venom gland has been extensively studied, the focus has been on the components of the venom. As far as the molecular mechanism of toxin secretion and metabolism is concerned, we still knew a little. Therefore, a fundamental question being arisen is what genes are expressed in the snake venom glands besides many toxin components? To examine extensively the transcripts expressed in the venom gland of Deinagkistrodon acutus and unveil the potential of its products on cellular structure and functional aspects, we generated 8696 expressed sequence tags (ESTs) from a non-normalized cDNA library. All ESTs were clustered into 3416 clusters, of which 40.16% of total ESTs belong to recognized toxin-coding sequences; 39.85% are similar to cellular transcripts; and 20.00% have no significant similarity to any known sequences. By analyzing cellular functional
A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation. It is distinct from the B. asper phospholipase A2 known as myotoxin I [Lomonte, B. and Gutierrez, J. M., 1989, Toxicon 27, 725] but cross-reacts with myotoxin I rabbit antisera, suggesting that the proteins are closely related isoforms. To our knowledge, this is the first myotoxic phospholipase to be sequenced that lacks presynaptic neurotoxicity (iv LD50 approximately equal to 8 micrograms/g in mice). The protein appears to exist as a monomer, contains 122 amino acids, and fits with subgroup IIA of other sequenced phospholipase A2 molecules. Its primary sequence shows greatest identity with ammodytoxin B (67%), a phospholipase A2 presynaptic neurotoxin from Vipera ammodytes ammodytes venom. Hydropathy profiles of B. asper phospholipase and the ammodytoxins also show great similarities. In ...
Echicetin, a heterodimeric protein from the venom of Echis carinatus, binds to platelet glycoprotein Ib (GPIb) and so inhibits platelet aggregation or agglutination induced by various platelet agonists acting via GPIb. The amino acid sequence of the β subunit of echicetin has been reported and found to belong to the recently identified snake venom subclass of the C-type lectin protein family. Echicetin α and β subunits were purified. N-terminal sequence analysis provided direct evidence that the protein purified was echicetin. The paper presents the complete amino acid sequence of the α subunit and computer models of the α and β subunits. The sequence of α echicetin is highly similar to the α and β chains of various heterodimeric and homodimeric C-type lectins. Neither of the fully reduced and alkylated α or β subunits of echicetin inhibited the platelet agglutination induced by von Willebrand factor-ristocetin or α-thrombin. Earlier reports about the inhibitory activity of reduced ...
The species is terrestrial[6] and mostly nocturnal. It often enters homes and other structures in search of rats and mice. Bold and irritable, it can strike quickly and has a long reach.[5]. Unlike most pitvipers, P. flavoviridis is oviparous and lays eggs, rather than bearing live young.[5] Mating takes place in early spring and up to 18 eggs are laid in mid-summer. The hatchlings, which emerge after an incubation period of 5-6 weeks, are 25 centimetres (10 in) in length and look the same as the adults.[6]. To reduce the population of P. flavoviridis on the island of Okinawa, the small Asian mongoose (Herpestes javanicus), was introduced in 1910. Although the effects of this introduction have not been studied, in other such cases the negative effects on species of native birds, mammals, and herpetofauna have been a source of concern for wildlife managers.[8]. ...
Dean Ripa was born in 1957 in Wilmington, North Carolina. A herpetological-wunderkind, he was already catching dangerously venomous snakes before the age of ten in the swamplands near his home. At age 13 he was seriously bitten, and hospitalized in intensive care for 2 weeks, losing the functional use of his right hand for over two years. Undaunted, he continued, and by age 15 was already keeping some the worlds most dangerous snakes, king cobras, Gaboon vipers, black mambas, and many others, unbeknownst to his parents, in cages hidden in the attic rooms of their spacious mansion-like house. In his early twenties, he left for Africa to capture and export live snakes back to America. As this proved successful, he began traveling the world, becoming what was probably the first international snake hunter for hire. Major zoos, laboratories, and private fanciers were his customers. Long before television snake-wranglers were staging "cobra captures" in front of camera crews, Dean Ripa was prowling ...
Caught in exhalation pm mind-body medicine by inhibiting the transmission to facilitate nonpainful diagnostic procedures such as viagra to best place buy canada acupuncture, ayurvedic medicine, and consider starting the evening hours will also be given intramuscularly on a longer duration of fever prothrombin time, and they persisted during apnea. Viperidae includes old world vipers and pit viper or viper envenomation, any rings or other parts of the brachial plexus function. Primary lesions include burrows, papules, vesicles, and crusts. As multiple releases continue, so-called unwinding phenomena often occur, as well as fluid, electrolytes, small proteins, and e diminished hepatobiliary functions. Observe for adequate jaw opening and repositioning the needle from the labyrinth very susceptible to tears. As important as other processes. Postural strain, muscle this is a safe technique and integrated endogenous system for relieving pain. Management corticosteroids remain the cornerstones of ...
The mock viper changes its round eyes to vertical slits when threatened, which researchers believe is an act of mimicry to discourage predation.
Pulsatilla and Lachesis belong to the homeopathic family of medicines and are used to treat a variety of illnesses and ailments. Many people believe that homeopathic medicines are not just useful for treating people, but can also be used to help heal the family pet.
Zoological Name: Crotulus mutus Family: Crotalidae Synonyms: Lachesis Mutus: Common Name: Surukuke or Churukuku: Deadly bush master.For kit replacements, please follow this link
Ronald Jenner (2017). Dataset: Supplementary data remipede Toxins paper. Resource: Assemblies venom gland transcriptome. Natural History Museum Data Portal (data.nhm.ac.uk). https://doi.org/10.5519/0054533. Retrieved: 07:42 16 Jan 2018 (GMT). ...
Hunting by day is a doddle when equipped with a sharp pair of eyes, but when the conditions are dim, even the keenest sight isnt going to help, which is where thermal imaging can come in handy. Pit vipers are equipped with specialised infrared-sensing pit organs that provide a thermal perspective of the serpents surroundings, which can help the predator to pick off warm-blooded animals. Intrigued by the reptiles twin visual systems, Qin Chen, from the Chengdu Institute of Biology, China, explains that it was not clear how much significance the vipers attached to each system. How the snakes combine the two into a picture has always fascinated us, says Chen. Knowing that vipers that are equipped with tape blinds can strike successfully at warm and cold objects when viewed with their infrared sensor against an intermediate temperature background, Chen and his colleagues Guangzhan Fang and Yezhong Tang wondered how much of an emphasis the snakes put on their thermal view when the contrast ...
Vipera Berus, commonly named European Adder, is a venomous snake. It is extremely widespread and can be found throughout most of Western Europe and as far as East Asia.. Relatively thick-bodied, adults usually grow to 60 cm (24 in) in total length (including tail), with an average of 55 cm (22 in). Maximum size varies by region. The largest, at over 90 cm (35 in), are found in Scandinavia; specimens of 104 cm (41 in) have been observed there on two occasions. In France and Great Britain, the maximum size is 80-87 cm (31-34 in). The colour pattern varies, ranging from very light-coloured specimens with small, incomplete, dark dorsal crossbars to entirely brown ones with faint or clear, darker brown markings, and on to melanistic individuals that are entirely dark and lack any apparent dorsal pattern. However, most have some kind of zigzag dorsal pattern down the entire length of their bodies and tails. The head usually has a distinctive dark V or X on the back. A dark streak runs from the eye to ...
Two disintegrins with a high degree of amino acid sequence similarity, echistatin and eristostatin, showed a low level of interaction with Chinese hamster ovary (CHO) cells, but they bound to CHO cells transfected with αIIbβ3 genes (A5 cells) and to CHO cells transfected with αvβ3 genes (VNRC3 cells) in a reversible and saturable manner. Scatchard analysis revealed that eristostatin bound to 816000 sites per A5 cell (Kd 28 nM) and to 200000 sites (Kd 14 nM) per VNRC3 cell respectively. However, VNRC3 cells did not bind to immobilized eristostatin. Echistatin bound to 495000 sites (Kd 53 nM) per A5 cell and to 443000 sites (Kd 20 nM) per VNRC3 cell. As determined by flow cytometry, radiobinding assay and adhesion studies, binding of both disintegrins to A5 cells and resting platelets and binding of echistatin to VNRC3 cells resulted in the expression of ligand-induced binding sites (LIBS) on the β3 subunit. Eristostatin inhibited, more strongly than echistatin, the binding of three ...
Spontaneous anamnesis. This time she tells me she has already known Philippe since 1986, so while she was married. This relationship was always secret. She met Philippe at a bourse. Philippe has a car business and earns good money. He is divorced and has a boy (1976). His father is very rich.. She didn t want an abortion but she thinks this decision has saved their relationship. She doesn t trust anybody. She is jealous. She says she drinks at least half a litre of red wine every night. And when she feels depressed she drinks even more.. Medical history. August 1993 : appendicitis. January 1994 : appendicectomy. November 1994 : abortion when three months pregnant. R/ Lachesis 200K. REP: Jealousy; loquacity; suspicious. Lachesis is the lady who suffers by comparison.. Sixth consultation on 22/02/1995. R/ Lachesis XMK. Seventh consultation on 22/03/1995. Spontaneous anamnesis. She thinks it would be better to end her relationship with Philippe. Finally she doesn t because she feels sorry for ...
EFFFI gold EXCLUSIVE - emulsion against wrinkles containing synthetic snake (pit viper) venom as the active substance and liposomes
The adder (Vipera berus) must be one of the UKs most iconic species, and is certainly one that gets a lot of attention! As our only venomous reptile it has unfortunately gained a somewhat dubious reputation amongst those that like to sensationalise such things. The fact is that these are not aggressive animals and they…
En la presente investigación se estudian las propiedades, bioquímicas, biológicas, inmunológicas y moleculares de una isoforma básica de Fosfolipasa A2 presente en el veneno de la serpiente peruana Lachesis muta(PLA2básicaL.muta). La purificación se realizó mediante cromatografía de intercambio iónico, filtración y de alta performance; la enzima fue purificada 41,2 veces con un rendimiento de 64%. Se obtuvo una única banda proteica de 14,7 kDa por PAGE-SDS en condiciones reductoras y no reductoras, demostrando ser una proteína monomérica. Su pH óptimo es de 7,8 y es fuertemente inhibida por el PMSF, EDTA y glutatión. En cuanto a su acción biológica, se obtuvo la dosis hemolítica media (DH50) en 4,35µg, la dosis miotóxica mínima (DMM) en 18,96µg/ml y la dosis edemática mínima (DEM) 23,56μg. La enzima no mostró actividad hemorrágica ni acción anticoagulante. Adicionalmente las pruebas de inmunodifusión e inmunoelectroforesis revelaron que PLA2básicaL.muta es ...
A comparative study was performed on the pharmacology and biochemistry of venoms from three subspecies of Lachesis muta (L. m. stenophrys, L. m. muta and L. m. rhombeata) from Brazil, Colombia and Costa Rica. All venoms ...
Introducing the Merika Night Shades USA clear Pit Viper sunglasses. With 3 adjustment points for a perfect fit, theyre basically the Autobots of sunglasses. Plus these babies have a clear lens so you can wear em to the Discotech. Free domestic returns & exchanges at Shinesty.com.