TY - JOUR. T1 - Enhancement of micronuclei frequency by vindesine in mouse bone marrow. AU - Jagetia, Ganesh Chandra. AU - Jyothi, P.. PY - 1997/1/15. Y1 - 1997/1/15. N2 - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.. AB - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of ...

TY - JOUR. T1 - Phase I1 study of vindesine in disseminated squamous cell carcinoma of the uterine cervix. T2 - An EORTC gynecological cancer cooperative group study. AU - Vermorken, J. B.. AU - Landoni, F.. AU - Pecorelli, S.. AU - Piccart, M. J.. AU - Van Der Burg, M.. AU - Ten Bokkel Huinink, W. W.. AU - George, M.. AU - Greggi, S.. AU - Rotmensz, N.. PY - 1991. Y1 - 1991. N2 - Vermorken JB, Landoni F, Pecorelli S, Piccart MJ, van der Burg MEL, ten Bokkel Huinink WW, George M, Greggi S, Rotmensz N. Phase I1 study of vindesine in disseminated squamous cell carcinoma of the uterine cervix: an EORTC Gynecological Cancer Cooperative Group study. Int Gynecol Cancer 1991; 1: 248-252. Twenty-nine patients with disseminated squamous cell carcinoma of the uterine cervix were treated with a 3 mg/m2 weekly i.v. bolus schedule of vindesine for 6 weeks (thereafter every 2 weeks). Twenty-seven patients were evaluable for response, 19 of whom had received prior chemotherapy (14 also vincristine). Five of ...

TY - JOUR. T1 - Cisplatin and vindesine combination chemotherapy for advanced carcinoma of the lung. T2 - A randomized trial investigating two dosage schedules. AU - Gralla, R. J.. AU - Casper, E. S.. AU - Kelsen, D. P.. AU - Braun, D. W.. AU - Dukeman, M. E.. AU - Martini, N.. AU - Young, C. W.. AU - Golbey, R. B.. PY - 1981/1/1. Y1 - 1981/1/1. N2 - Eighty-five patients with advanced squamous carcinoma or adenocarcinoma of the lung were randomly assigned to receive vindesine with either high dose (120 mg/m2 of body surface area) or low dose (60 mg/m2) cisplatin. All patients had measurable disease and had not previously received chemotherapy. The response rate was similar with both treatments (43% complete and partial remission rate), but the high dose cisplatin regimen was superior to the low dose in median duration of response (12 versus 5.5 months; p = 0.05) and in median survival for responding patients (21.7 versus 10 months; p = 0.02). Myelosuppression was generally not a treatment ...

ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...

CHIBA, Japan-Combining either irinotecan (Camptosar) or vindesine with cis-platin (Platinol) produced similar objective responses and survival rates in patients with stage IIIB or IV non-small-cell lung cancer, according to final results of a randomized trial. 1

en] Purpose: Randomized trial LNH93-3 was conducted on patients who had poor-prognosis aggressive lymphoma and were younger than 60 years with two to three factors of the age-adjusted International Prognostic Index to evaluate the benefit of early high-dose therapy (HDT) with autologous stem-cell transplantation (ASCT). Patients and Methods: Patients were randomized between doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (ACVBP) chemotherapy followed by sequential consolidation and an experimental shortened treatment consisting of three cycles with escalated doses of cyclophosphamide, epirubicin, vindesine, bleomycin, and prednisone and collection of peripheral-blood stem cells. On day 60, HDT was administered with 1,3-bis(2-chloroethyl)-1-nitrosourea, etoposide, cytarabine, and melphalan followed by ASCT. Results: Eligible patients (n = 370) with aggressive lymphoma were analyzed. For ACVBP (181 patients) and HDT (189 patients), respective complete remission rates were 64% ...

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Pharmacokinetic peak and trough concentration of each study drug when given in combination together or in a sequenced regimen [ Time Frame: Cohorts 1-5: Day 1, 2, 3, 8, 15, 22, 43, 64, 85, 106, 127, 148, 169, 253 & 6 & 12 weeks after last dose of study drug. Cohort 6-7: Day 1, 57, 113, 225, 337, 449, 561 & 6 & 12 weeks after last dose of study drug ...

NeoServer provide Flexible Linux VPS. You can easily scale up the CPU, RAM and disk at any time, when you need it. Pay only for those resources that you need today.

W32/Genome.VRB!tr.dldr is classified as a downloader trojan. Downloader Trojan has the capability to download other malicious files or an updated version...

Courseaux A et. al. (1996) Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe dEtude des Néoplasies Endocriniennes Multiples de type 1).. [^] ...

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PURPOSE: The primary objective of this study was to compare the survival of patients with unresectable stage III non-small-cell lung cancer (NSCLC) treated with combined chemoradiotherapy with or without thalidomide. PATIENTS AND METHODS: Patients were randomly assigned to the control arm (PC) involving two cycles of induction paclitaxel 225 mg/m(2) and carboplatin area under the curve (AUC) 6 followed by 60 Gy thoracic radiation administered concurrently with weekly paclitaxel 45 mg/m(2) and carboplatin AUC 2, or to the experimental arm (TPC), receiving the same treatment in combination with thalidomide at a starting dose of 200 mg daily. The protocol allowed an increase in thalidomide dose up to 1,000 mg daily based on patient tolerability. RESULTS: A total of 546 patients were eligible, including 275 in the PC arm and 271 in the TPC arm. Median overall survival, progression-free survival, and overall response rate were 15.3 months, 7.4 months, and 35.0%, respectively, for patients in the PC arm, in

cerebral radionecrosis.. Neuropathy, a problem that sometimes occurs with chemotherapy treatment. It is damage to the nerves. It can occur from some chemotherapy drugs used in conventional cancer treatment.. There are three major goups of nerves in the human body, the peripheral nerves that carry information to and from the limbs, the nerves that supply the bowels and other internal organs, and the nerves of the head which connect to the ears, eyes, taste buds, etc. Nerves in any or all of these major groups can be affected by certain chemotherapy drugs. Nerves are vulnerable to many kinds of damage. They can be damaged by certain cancers. This may be caused by the cancer cells producing a particular kind of biological agent that interferes with the function of the nerves. Sometimes, they can be damged by drugs used in chemotherapy treatment. The chemotherapy drugs that most likely cause nerve damage are the vinca alkaloids(vincristine, vindesine and vinblastine), platinum drugs(cisplatinum, ...

Randomized. 524 patients with NSCLC Stage IIIA (33%) or resectable IIIB (67%). Arm 1) Induction cisplatin 55 mg/m2 + etoposide 100 mg/m2 x3 cycles, then concurrent RT 45/30 in 1.5 Gy BID with carboplatin 100 mg/m2 + vindesine 3mg, followed by surgery vs. Arm 2) Same induction, followed by surgery, followed by RT (54/30 if R0, 68.4/38. Surgery after 4-6 weeks. Primary endpoint PFS ...

Vor allem Mittelständler weisen im Risikomanagement, einer Kernaufgabe für die Zukunftsfähigkeit jeder Institution, noch Defizite auf. VdS wird als neues Mitglied in der „Risk Management Association e.V. (RMA) einen Fokus auf konkrete Hilfestellungen zu dieser Herausforderung legen. ...

This is a Phase I, open-label, multicenter, pharmacokinetic study of MDX-010 in up to 90 evaluable subjects with surgically unresectable malignant melan

Groupe Hospitalier Le Raincy - Montfermeil, Service donco-hématologie, France is an ESMO Designated Centre of Integrated Oncology and Palliative Care

Publicis Groupe, graphique historique - logiciel danalyse technique de bourse en ligne, paramétrable avec sauvegarde de votre travail - affichage de 1 jour à 25 ans

Tankard (chope en anglais) est un groupe de thrash metal aux influences punk fondé en 1982 à Francfort. Le groupe définit lui-même son style comme étant du

Purpose In this large cohort of Hodgkins lymphoma survivors with long follow-up, we estimated the impact of treatment regimens on premature ovarian failure (POF) occurrence and motherhood, including safety of nonalkylating chemotherapy and dose-response relationships for alkylating chemotherapy and age at treatment. Patients and Methods The Life Situation Questionnaire was sent to 1,700 women treated in European Organisation for Research and Treatment of Cancer and Groupe dEtude des Lymphomes de lAdulte trials between 1964 and 2004. Women treated between ages 15 and 40 years and currently not using hormonal contraceptives (n = 460) were selected to assess occurrence of POF. Cumulative POF risk was estimated using the life-table method. Predictive factors were assessed by Cox regression analysis. Results Median follow-up was 16 years (range, 5 to 45 years). Cumulative risk of POF after alkylating chemotherapy was 60% (95% CI, 41% to 79%) and only 3% (95% CI, 1% to 7%) after nonalkylating ...

PubMed journal article: Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow. Download Prime PubMed App to iPhone, iPad, or Android

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Stinchcombe TE, Zhang Y, Vokes EE, Schiller JH, Bradley JD, Kelly K, Curran WJ, Schild SE, Movsas B, Clamon G, Govindan R, Blumenschein GR, Socinski MA, Ready NE, Akerley WL, Cohen HJ, Pang HH, Wang X. Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies. J Clin Oncol. 2017 Sep 01; 35(25):2885-2892 ...

spinning around too fast on an office chair for too long. Thats 6 potential causes of dizziness. Now lets say you notice some severe dizziness that wont go away. You go to the doctor and he tells you that you have VDS and that the only treatment for VDS is spinning you anti-clockwise on an office chair. Now this treatment for VDS may work, but ONLY in those who became dizzy due to spinning clockwise on an office chair. Everyone else will find that this treatment does nothing for them, or makes them feel dizzier. So what next? Visit internet forums for support? Eating regularly with a specific ratio of carbs/fats/proteins is THE cure to VDS… How I cured my VDS with salt and water… etc. These approaches will work for you ONLY if you share the same root causes and same metabolic balance. This is possible but unlikely; rehydrating might work for some, but what about the individuals whose dizziness was down to poor cholinergenic function? Or those people with adrenal imbalance? Or those ...

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Revue de Chirurgie Orthopédique et Traumatologique - Vol. 88 - N° 3 - p. 264-270 - Enclouage par clou gamma long dans les fractures sous-trochantériennes et trochantéro-diaphysaires du fémur de ladulte - EM|consulte

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ResultsA total of 1867 patients underwent randomization; 36.5 percent had pathological stageI disease, 24.2 percent stage II, and 39.3 percent stage III. The drug allocated with cisplatinwas etoposide in 56.5 percent of patients, vinorelbine in 26.8 percent, vinblastine in11.0 percent, and vindesine in 5.8 percent. Of the 932 patients assigned to chemotherapy,73.8 percent received at least 240 mg of cisplatin per square meter of body-surfacearea. The median duration of follow-up was 56 months. Patients assigned to chemotherapyhad a significantly higher survival rate than those assigned to observation (44.5 percentvs. 40.4 percent at five years [469 deaths vs. 504]; hazard ratio for death, 0.86; 95percent confidence interval, 0.76 to 0.98; P,0.03). Patients assigned to chemotherapyalso had a significantly higher disease-free survival rate than those assigned to observation(39.4 percent vs. 34.3 percent at five years [518 events vs. 577]; hazard ratio, 0.83;95 percent confidence interval, 0.74 to ...

The management of unresectable stage III and stage IV melanoma (metastatic or advanced melanoma) has been revolutionised with effective drug therapies t...

Le Groupe Decant est fier de ses actions solidaires. Le groupe, parrain de lassociation, les Orchid es Blanches a galement mis en place une politique sociale dont l ambition est d tre un mod le au sein de la profession

Before I bore you with more simulations, here is how the chosen configuration compares to driving the solenoid without any dampening/snubbing. Please note that the MOSFET I have chosen (Infineon BSC040N10NS5ATMA1) has a Vds rating of 100 V, which if exceeded will eventually destroy the semiconductor junction (as you see in the simulation with the 110 V peak...). One other thing to note is that I have chosen to use a dedicated gate driver (TI UCC27533, see section 10.2.1.2.4 of datasheet on how to spec driver), as I am am working with a limited PCB area (as in have bugger all space to make a gate driver using discrete components). ...

Sexually Transmitted Diseases (STDs), also known as sexually transmitted infections (STIs), or venereal diseases (VDs) are diseases that spread majorly through person-to-person sexual contact.

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The range of batteries, or energy storage machines, we offer have a reference showing the number of kilowatts of power output and the number of kilowatt hours of storage.. A 30/150, for example, is a flow battery with 30kW of power and 150kWh of storage with the ability to provide the 30kW for 5 hours; a 250/2000 is a flow battery with 250kW of power output and 2000kWh (2MWh) of storage with the ability to deliver 250kW of power for 8 hours.. All the batteries are scalable and can be added together in multiples to suit your requirements.. ...

Clarix tous sèche sirop adulte est un traitement de courte durée des toux sèches et des toux dirritation chez ladulte (à partir de 15 ans).

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PREFIX dcterms: ,http://purl.org/dc/terms/, PREFIX def-bw: ,http://environment.data.gov.uk/def/bathing-water/, PREFIX def-bwq: ,http://environment.data.gov.uk/def/bathing-water-quality/, PREFIX def-ef: ,http://location.data.gov.uk/def/ef/SamplingPoint/, PREFIX qb: ,http://purl.org/linked-data/cube#, PREFIX rdf: ,http://www.w3.org/1999/02/22-rdf-syntax-ns#, PREFIX rdfs: ,http://www.w3.org/2000/01/rdf-schema#, PREFIX skos: ,http://www.w3.org/2004/02/skos/core#, PREFIX time: ,http://www.w3.org/2006/time#, CONSTRUCT {?item def-bwq:discounted ?___7 . ?item def-bwq:sampleWeek ?___8 . ?___8 rdfs:label ?___9 . ?item def-bwq:bathingWater ?___10 . ?___10 skos:prefLabel ?___11 . ?item def-bwq:discountable ?___12 . ?item qb:dataSet ?___13 . ?item dcterms:source ?___14 . ?item def-bwq:bathingWater ?___15 . ?___15 def-bw:eubwidNotation ?___16 . ?item def-bwq:samplingPoint ?___17 . ?___17 skos:prefLabel ?___18 . ?item rdf:type ?___19 . ?item def-bwq:sampleDateTime ?___20 . ?___20 time:inXSDDateTime ?___21 . ...

Cancer is one leading causes of death worldwide. Gene therapy belongs to the promising options for treatment of malignant tumors. The non-viral gene therapy is known as safer alternative to the viral gene therapy. For non-viral gene transfer the vector and the transfer technology are of crucial importance. As part of this work a clinical trial was performed to assess efficiency and safety of the non-viral jet-injection. It was shown, that this technology can be used safely in a clinical setting. As a result of this clinical trial we concluded, that vector safety and especially efficiency need further improvements. Based on this optimized non-viral vectors (minicircle, MIDGE) were compared with each other and their respective parental plasmids. The MIDGE vector showed the highest transgene expression due to increased transcription. In preparation of a clinical trial the combined treatment of hTNF-alpha gene transfer and Vindesine chemotherapy was analyzed. Again, the MIDGE vector showed the ...

Informatica Vibe Data Stream (VDS) is an industrial strength, automated data ingestion engine that connects real-time data from wide variety of sources for processing on Amazon Kinesis. VDS minimizes the need for hand coding and reduces the time to develop new stream processing applications. Adding new data sources and processing targets is fast and easy. Because VDS simplifies and automates the direct data flow between sources and targets, your IT team can spend less time managing streaming data and more time leveraging it for strategic or efficiency gains. VDS is designed for continuous ingestion and timely processing of streaming data on commodity hardware with no need for intermediate data staging or brokered mediation ...

Les meningites de ladulte au Centre hospitalier universitaire vaudois. Diagnostic, prise en charge et evolution de 112 cas. [Meningitis in adults at the Vaudois University Hospital Center. Diagnosis, management and development of 112 cases]

AOD4184A 40V N-Channel MOSFET General Description Product Summary The AOD4184A combines advanced trench MOSFET technology with a low resistance package to provide extremely low RDS(ON). This device is well suited for high current load applications. VDS 40V 50A ID (at VGS=10V) RDS(ON) (at VGS=10V) , 7mΩ RDS(ON) (at VGS = 4.5V) , 9.5mΩ 100% UIS Tested 100% Rg Tested TO252 DPAK Top View D Bottom View D D S G G S S G Absolute Maximum Ratings TA=25°C unless otherwise noted Symbol Parameter VDS Drain-Source Voltage VGS Gate-Source Voltage Continuous Drain Current G TC=25°C Pulsed Drain Current C Avalanche Current C Avalanche energy L=0.1mH C TC=25°C Power Dissipation B TA=25°C Power Dissipation A Junction and Storage Temperature Range Thermal Characteristics Parameter Maximum Junction-to-Ambient A AD Maximum Junction-to-Ambient Maximum Junction-to-Case Rev0 : Sep 2009 IAS, IAR 35 A EAS, EAR 61 mJ 50 Steady-State Steady-State W 25 2.3 RθJA RθJC www.aosmd.com W 1.5 TJ, TSTG Symbol t ≤ 10s A ...

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How is Maximum Vehicle Protection abbreviated? MVP stands for Maximum Vehicle Protection. MVP is defined as Maximum Vehicle Protection somewhat frequently.

Question - Could having MVP cause a slightly enlarged spleen? I have a - M. Find the answer to this and other Cardiology questions on JustAnswer

PFS rate=probability patient was progression-free at Day 78, calculated as total patients receiving treatment and with an overall response of stable disease (SD), partial response (PR), or complete response (CR) at Week 12, divided by total patients. For those alive and not progressed at or before Week 12, PFS censored on date of last evaluable tumor assessment (TA) at or before Week 12. Those with an assessment of PD prior to Week 12 and subsequent assessment of SD, PR, or CR at Week 12 were called progression-free at Week 12. Those with no recorded postbaseline TA dated on or before Day 109, and who had not died on or before Day 109, were censored at randomization. PD=at least 25% increase in sum of products of all index lesions or appearance of any new lesions. Both an investigator and independent review committee (IRC) assessed radiologic imaging studies, photographs of skin lesions, and clinical data. IRC assessment was considered primary over that of the investigators ...

Eva Benetatou zeigt zum ersten Mal ihren Babybauch Bilder Vor 1 Stunde. Michelles weitere Freunde sind Derek Boyd, Lisa Leeper und Aaron Bailey, den sie seit Www.Freenet.Tv Registrierung Kindergarten kennt und der hin und wieder gemein zu ihr ist. The Flintstone Kids Just Say No Special. Authority control BNF : Full House Schauspieler data ISNI : LCCN : no MBA : c16fd0dfabaeed4 VIAF : WorldCat Identities : lccn-no Sein Geburtsname ist Hermes Katsopolis, doch da er als Kind deswegen stark gehänselt wurde, bat er seine Eltern, seinen Vornamen in Jesse zu ändern. Deutscher Titel. Matt Harmon 5 Fans. Second Chance. X-Men Apocalypse Stream Deutsch hugely Paypal Auf Bankkonto überweisen rapper has met Trump on several occasions, including on a visit to the White House. Lesley Miller 1 Fan. The Real Ghostbusters. Als Michelle älter wird, rückt sie Die Schwarze Wittwe mehr in den Mittelpunkt der Show und wird verstärkt in die Handlung miteinbezogen. Love Again - Jedes Ende ist ein neuer Anfang. ...

The goal of this clinical research study is to learn if Lenvatinib can help to control advanced melanoma that has not responded to treatment. The safety of the study drug will also be studied.

Voici le nouveau clip du groupe électro Moullinex, sur le titre « Catalina ». Un rendu intéressant grâce à une réalisation entièreme