As reported in The Lancet Oncology, Tilly et al found that the combination of polatuzumab vedotin, an antibody-drug conjugate targeting the CD79b component of the B-cell receptor, with immunochemotherapy showed high response rates in the phase II portion of a phase I/II study in previously untreated diffuse large B-cell lymphoma.. The phase II expansion of the study (conducted at 11 sites in the United States and France) included 66 patients with newly diagnosed disease. Patients received the polatuzumab vedotin recommended phase II dose of 1.8 mg/kg on day 2 of cycles 1 and 2 and on day 1 of subsequent 21-day cycles in combination with R-CHP (rituximab plus cyclophosphamide, doxorubicin, and prednisone; n = 45) or obinutuzumab plus CHP (G-CHP; n = 21) for a total of 6 or 8 cycles according to investigator preference.. Adverse Events. Among the patients receiving the phase II dose of polatuzumab vedotin, the most common adverse events of grade ≥ 3 were neutropenia (30%), febrile neutropenia ...

PRIMARY OBJECTIVES:. I. To compare the event-free survival of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone (R-CHOP) versus dose-adjusted (DA-) etoposide, prednisone, vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, and rituximab (EPOCH-R) chemotherapy in untreated cluster of differentiation (CD)20 positive (+) diffuse large B-cell lymphomas.. II. To develop a molecular predictor of outcome of R-CHOP and DA-EPOCH-R chemotherapy using molecular profiling.. SECONDARY OBJECTIVES:. I. To compare the response rates, overall survival and toxicity of R-CHOP versus DA-EPOCH-R.. II. To define the pharmacogenomics of untreated diffuse large B-cell lymphoma (DLBCL) and correlate clinical parameters (toxicity, response, survival outcomes and laboratory results) with molecular profiling.. III. To assess the use of molecular profiling for pathological diagnosis. IV. To identify new therapeutic targets using molecular profiling. V. To perform a ...

Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine.. Patients are randomized to receive intravenous DOX-SL alone or in combination with vincristine/bleomycin every 2 weeks. Filgrastim ( granulocyte colony-stimulating factor; G-CSF ) may be given as needed for neutropenia.. AS PER AMENDMENT 11/7/96: Based on interim review data, it is recommended that subjects receiving DOX-SL plus vincristine/bleomycin have vincristine/bleomycin discontinued and receive DOX-SL alone unless, in the opinion of the treating physician, they are benefitting from the DOX-SL plus vincristine/bleomycin regimen. ...

This study is currently recruiting participants. Verified May 2012 by UNC Lineberger Comprehensive Cancer Center First Received on November 2, 2010. &n…

Twelve patients with primary non-Hodgkins lymphomas of the CNS are described. Out of 5 CSF cytologies performed, 4 were positive. Radiotherapy was given to the tumour area in 3 patients, or to the whole brain in 5 patients. Four cases received radiotherapy to the spinal cord as well. Patients receiving ... read more whole CNS irradiation, including the spinal cord, seem to have a longer survival than patients with brain irradiation only. Out of the 5 patients with total brain irradiation, 2 showed a relapse in the spinal cord. It is suggested that therapy should be given not only to the tumour bearing areas, but should comprise the entire CNS. show less ...

Hana Biosciences, a biopharmaceutical company focused on advancing cancer care, recently announced that the US Food and Drug Administration (FDA) has granted orphan drug designation for vincristine sulfate liposomes injection (Marqibo) in the treatment of adult patients with acute lymphoblastic leukemia (ALL). 1

SILVER SPRING, Md. - The Food and Drug Administration has approved a new drug for treating a rare type of leukemia, the agency said Thursday.. The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...

This study aimed to systematically review and meta-analyze the value of pretransplant FDG-PET in predicting outcome after autologous stem cell transplantation (ASCT) in aggressive non-Hodgkin lymphoma. Medline was systematically searched, included studies were methodologically assessed and meta-analyzed, when possible. Overall methodological quality of included studies (n=11) was poor, with moderate ... read more risk of bias in the domains of study participation (n=7) and prognostic factor measurement (n=7), and high risk of bias in the domains of outcome measurement (n=10), and study confounding (n=11). In all aggressive non-Hodgkin lymphomas, pooled sensitivity and specificity were 54.0% and 73.1% in predicting treatment failure, and 54.5% and 68.7% in predicting death. Because of interstudy heterogeneity, additional subgroup analyses were performed. In newly diagnosed aggressive non-Hodgkin lymphoma, pooled sensitivity and specificity were 20.0% and 70.0% in predicting treatment failure, and ...

1 Hermans J, Drol AD, van Groningen K, et al. International Prognostic Index for aggressive non-Hodgkin lymphoma is valid for all malignancy grades. Blood. 1995l86:1460-1463.. 2 Alici S, Bavbek SE, Kaytan E, et al. Prognostic significance of the immunophenotype versus the International Prognostic Index in aggressive non-Hodgkin lymphoma. Clinical Lymphoma. 2003;4:52-55.. 3 De Santis V, Martelli M, Anticoli AP, et al. Localized stage I-IE aggressive non-Hodgkin lymphoma (NHL): results of prospective study with multimodality therapeutic approach. Anticancer Research. 2001;21:4169-4172.. 4 Bernard M, Cartron G, Rachieru P, et al. Long-term outcome of localized high-grade non-Hodgkin lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study. Haematologica. 2005:90:802-809.. 5 Roche. Study of MabThera in aggressive non-Hodgkin lymphoma in patients less than 60 years old halted two years early due to ...

TY - JOUR. T1 - Rituximab plus CHOP as an initial chemotherapy for patients with disseminated MALT lymphoma [4]. AU - Ennishi, Daisuke. AU - Yokoyama, Masahiro. AU - Mishima, Yuko. AU - Watanabe, Chie. AU - Terui, Yasuhito. AU - Takahashi, Shunji. AU - Takeuchi, Kengo. AU - Ikeda, Kazuma. AU - Tanimoto, Mitsune. AU - Hatake, Kiyohiko. PY - 2007/11. Y1 - 2007/11. UR - http://www.scopus.com/inward/record.url?scp=36048934446&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=36048934446&partnerID=8YFLogxK. U2 - 10.1080/10428190701636476. DO - 10.1080/10428190701636476. M3 - Article. C2 - 17990181. AN - SCOPUS:36048934446. VL - 48. SP - 2241. EP - 2243. JO - Leukemia and Lymphoma. JF - Leukemia and Lymphoma. SN - 1042-8194. IS - 11. ER - ...

PRIMARY OBJECTIVES: I. To determine the event-free survival (EFS) and overall survival (OS) of children with completely resected ependymoma treated with maintenance chemotherapy comprising vincristine sulfate, cisplatin, etoposide, and cyclophosphamide (VCEC) versus observation following post-operative conformal radiotherapy (cRT). SECONDARY OBJECTIVES: I. To estimate the EFS and OS of children with incompletely resected ependymoma who are unable to achieve a complete response (CR) by post-operative induction chemotherapy or by second surgery who are non-randomly assigned to cRT followed by VCEC. II. To further evaluate the EFS and OS of children with supratentorial classic ependymoma who achieve a complete resection at first or second resection or children who achieve a CR to short-course induction chemotherapy following first surgery. III. To determine the neurologic, neuropsychological, and endocrine long-term sequelae of surgery, cRT, and VCEC as compared to those patients treated on ...

The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL).. ALL is a rapidly progressing form of blood and bone marrow cancer that is more commonly diagnosed in children than adults. According to the National Cancer Institute, an estimated 6,050 men and women will be diagnosed with ALL and 1,440 will die from the disease this year.. Marqibo is approved for patients whose leukemia has returned (relapsed) two or more times, or whose leukemia has progressed following two or more regimens of anti-leukemia therapy. Marqibo contains vincristine, a commonly used anti-cancer drug, encased within a liposome, a drug delivery vehicle composed of material similar to that of cell membranes. It is an injection administered once a week by a health care professional.. Marqibos approval demonstrates the FDAs commitment to the development and ...

Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation

Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation

On Tuesday the 2nd Kyler had a Bone Marrow Biopsy, which confirmed his Leukemia diagnosis and on Wednesday the 3rd he had his MediPort put in and his first Lumbar Puncture with Cytarabine chemotherapy. Thursday the 4th he started a twice daily oral steroid Dexamethasone and had his first weekly IV Vincristine treatment. On Sunday the 7th he had Pegaspargase chemotherapy. He stayed in the hospital receiving daily oral medicine and a few platelet transfusions until Thursday the 11th. On that Thursday Kyler received his second dose of Vincristine and his second Lumbar Puncture this time with Methotrexate chemotherapy and he was released to go home that evening. He continued receiving his oral medicine twice a day and on each Monday he has been having check ups to make sure his levels are staying on par with where they should be. On Thursdays he has his weekly Vincristine treatments. ...

Hana Biosciences has initiated a multicenter phase II clinical trial of Marqibo (vincristine sulfate liposome injection) in patients with relapsed or refractory acute lymphoblastic leukemia (ALL). The study is designed to support a phase III pivotal clinical trial of Marqibo for ALL, the company said in a press release. The primary objective of the phase II open-label study is to assess the efficacy of weekly doses of Marqibo plus pulse dexamethasone as measured by complete response rate. Hana expects to enroll up to 44 patients. ...

Background Telomere shortening is certainly thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. fusion of chromosomes at the ends [3], which results in instability of the genome and contributes to carcinogenesis. Therefore, studies on telomeres and telomerase have been a major focus of cancer research, including studies on hematologic malignancies [4,5,6,7]. MDS represents a series of clonal hematopoietic stem cell diseases that show cytopenia due to ineffective Vincristine sulfate hematopoiesis and morphologic dysplasia of the hematopoietic cells, and is associated with an increased risk of progression to AML [8]. Abnormal proliferation of dysplastic hematopoietic cells and peripheral cytopenia in MDS reflects the paradoxical coexistence of active proliferation and apoptosis. Several markers and prognostic scoring systems have been developed to predict AML ...

Newly diagnosed mantle cell lymphoma, admitted now to start chemotherapy. She will start treatment with hyperfractionated cyclophosphamide, vincristine,

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Introduction Severe leukemias very rarely present with jaundice. patient was treated with a hyperfractionated cyclophosphamide/vincristine/doxorubicin/dexamethasone regimen. Conclusion Acute lymphoblastic leukemia ought to be among the differential diagnoses that needs to.... ...

BioAssay record AID 464197 submitted by ChEMBL: Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.121 uM vincristine.

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We describe the effect and side effects in two children with cancer treated with intravenous methadone due to vincristine-induced neuropathy.

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Evidence-based information on vincristine from hundreds of trustworthy sources for health and social care. Make better, quicker, evidence based decisions. Evidence search provides access to selected and authoritative evidence in health, social care and public health.

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TY - JOUR. T1 - Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP. T2 - Report from an International DLBCL Rituximab-CHOP Consortium Program Study. AU - Xu-Monette, Zijun Y.. AU - Wu, Lin. AU - Visco, Carlo. AU - Tai, Yu Chuan. AU - Tzankov, Alexander. AU - Liu, Wei Min. AU - Montes-Moreno, Santiago. AU - Dybkær, Karen. AU - Chiu, April. AU - Orazi, Attilio. AU - Zu, Youli. AU - Bhagat, Govind. AU - Richards, Kristy L.. AU - Hsi, Eric D.. AU - Zhao, X. Frank. AU - Choi, William W.L.. AU - Zhao, Xiaoying. AU - Van Krieken, J. Han. AU - Huang, Qin. AU - Huh, Jooryung. AU - Ai, Weiyun. AU - Ponzoni, Maurilio. AU - Ferreri, Andrés J.M.. AU - Zhou, Fan. AU - Kahl, Brad S.. AU - Winter, Jane N.. AU - Xu, Wei. AU - Li, Jianyong. AU - Go, Ronald S.. AU - Li, Yong. AU - Piris, Miguel A.. AU - Møller, Michael B.. AU - Miranda, Roberto N.. AU - Abruzzo, Lynne V.. AU - Medeiros, L. Jeffrey. AU - Young, Ken H.. PY - 2012/11/8. Y1 - ...

Stratifying diffuse large B-cell lymphoma patients treated with chemoimmunotherapy: GCB/non-GCB by immunohistochemistry is still a robust and feasible marker.

In this study, a retrospective analysis was done to evaluate the influence of TP53 Arg72Pro on the prognosis of 425 Chinese DLBCL patients treated with CHOP or R-CHOP therapy. Patients with genotype GG (Arg/Arg) and GC (Arg/Pro) of SNP rs1042522 had a lower positive rate for β2-MG and higher CR and OR rates for treatment than those with genotype CC (Pro/Pro). In the subgroup treated without rituximab, a significant higher CR rate and higher 5-year OS and PFS rates were achieved in patients with Arg/Arg and Arg/Pro than in those with Pro/Pro. Multivariate analysis revealed TP53 Arg72 as a favorable prognostic factor in this group. As the integration of rituximab in treatment significantly increased the CR, 5-year OS and PFS rates in the subgroup treated with R-CHOP therapy these significant differences vanished between two genotype groups.. The previous study in European Caucasians demonstrated no influence of TP53 Arg72Pro on survival of DLBCL patients [15]. However, we observed better survival ...

John M. Burke, MD, Rocky Mountain Cancer Centers, discusses the significant findings of the phase III GOYA study investigating obinutuzumab (Gazyva) plus CHOP in patients with previously untreated diffuse large B-cell lymphoma (DLBCL).

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The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...

This randomized phase III trial studies how well combination chemotherapy with or without ganitumab works in treating patients with newly diagnosed Ewing sarcoma that has spread to other parts of the body. Monoclonal antibodies, such as ganitumab, may block tumor growth in different ways by targeting certain cells. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, ifosfamide, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination chemotherapy is more effective with or without ganitumab in treating patients with newly diagnosed Ewing sarcoma ...

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SANTA MONICA, Calif., Aug. 25, 2014 (GLOBE NEWSWIRE) -- Kite Pharma, Inc., (Nasdaq:KITE), a clinical-stage biopharmaceutical company focused on developing engineered autologous T cell therapy (eACT™) products for the treatment of cancer, today announced the publication of clinical results in a cohort of patients demonstrating the potential to treat aggressive non-Hodgkins lymphoma with an anti-CD19 chimeric antigen receptor (CAR) T cell therapy. Kites most advanced product candidate, KTE-C19, is an anti-CD19 CAR T cell therapy that involves genetically modifying a patients T cells to express a CAR that is designed to target CD19, a protein expressed on the cell surface of B cell lymphomas and leukemias.. The findings from an ongoing Phase 1-2a clinical trial funded by Kite and conducted by the Surgery Branch of the National Cancer Institute (NCI) demonstrated that in 12 out of 13 evaluable patients with advanced B-cell malignancies, administration of anti-CD19 CAR T cells resulted in ...

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Antibodies and reagents. Phycoerythrin-labeled or FITC-labeled CD19 and TNFα antibodies and blocking Fas antibodies were purchased from PharMingen (San Francisco, CA). Lipopolysaccharide, actinomycin D, cycloheximide, and phorbol dibutyrate were from Sigma (St. Louis, MO). Stock solutions of phorbol dibutyrate (5 mg/mL) were made in DMSO. Dexamethasone (Pharmascience Inc., Montreal, Quebec), IFNα2b (Schering Canada Inc., Pointe-Claire, Quebec), Remicade (anti-TNF antibody; Schering Canada), vincristine sulfate (Faulding Canada Inc., Kirkland, Quebec), doxorubicin (Adriamycin; Pfizer, Canada Inc., Kirkland, Quebec), fludarabine phosphate (Berlex Canada Inc. Pointe-Claire, Quebec), and cyclosporin A (Novartis Canada Inc., Dorval, Quebec) were purchased from the hospital pharmacy. SP600125 (JNK inhibitor), MG-132 (proteasome inhibitor), and caffeic acid phenylester (CAPE; NF-κB inhibitor) were from Calbiochem (San Diego, CA), and stock solutions (25 mg/mL) were made in DMSO. The TLR7/8 agonist, ...

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in European Journal of Haematology (2007), 78(5), 399-404. BACKGROUND: Several papers have reported an association of high CA125 serum levels with advanced non-Hodgkins lymphoma (NHL) as well as a relationship between high CA125 values and poor outcome. PATIENTS ... [more ▼]. BACKGROUND: Several papers have reported an association of high CA125 serum levels with advanced non-Hodgkins lymphoma (NHL) as well as a relationship between high CA125 values and poor outcome. PATIENTS AND METHODS: Ninety-nine patients with NHL or Hodgkins disease (HD) underwent serum CA125 assessment at diagnosis. Gender, age, presence of B symptoms, performance status (PS), histology, sites of tumor involvement, presence of effusion, clinical stage, age-adjusted International Prognostic Index, C-reactive protein (CRP), Hb, lactate deshydrogenase (LDH) and beta2-microglobulin were evaluated for their association with serum CA125 levels. The impact of CA125 levels and other features on overall (OS) and ...

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Tytu : Phase 3 study of frontline rituximab, cyclophosphamide, doxorubicin, and prednisone plus vincristine (R-CHOP) or bortezomib (VR-CAP) in transplantation-unsuitable mantle cell lymphoma (MCL) patients ...

CHOP chemotherapy (cyclophosphamide, doxorubicin and vincristine chemotherapy with the steroid prednisolone) is the standard treatment for T-cell lymphoma. However, some people do not respond well to CHOP and alternative treatments are needed.

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Vinny I take it that you are Italian? I am also so we had to change our Italian diets a bit- smiles- although I still have my pasta once a week. Like you I have stage 4 NHL lymphoma diagnosed in June, 2011 by a PET Scan procedure. Ive had 6 rounds of chemo both Rituxin plus Vincristine and Cytoxen- am now on every other month rituxin maint and my doc is weaning me off of prednisone. My biggest challenge has been the 24-7 need to urinate which works to make sleeping a bit of a problem. Im hoping that by getting off the predisone this problem will ease a bit.I do take it a day at a time and am so grateful for a loving family including my mom at age 98 who calls me every day to encourage me and offer pasta dinners (smiles) Like you I have B cell lymphoma so we have the same cancer. I just turned 70 in November so my recovery is a bit more tricky at my age. My blood doc is so devoted and treats me like a son even though I am 12 years older than he and his RN wife who gives me my chemo treats me ...

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Patients in group I, excluding extremity alveolar (EA) RMS, were randomized to standard vincristine (V), dactinomycin (A), and cyclophosphamide (C) or standard VA. At 5 years, disease-free survival (DFS) and survival (S) rates were similar between VAC and VA (DFS: 80%, 70%, P = 0.47; S: 85%, 84%, P = 0.73). Patients in group II, excluding EA RMS, received radiation and were randomized to intensive VA or repetitive-pulse VAC. Outcomes were similar for rates of DFS (69%, 74%, P = 0.83) and S (88%, 79%, P = 0.17). Patients in group III, excluding certain pelvic tumors, received radiation and were randomized to repetitive-pulse VAC or repetitive-pulse VAdrC-VAC (Adr, Adriamycin [doxorubicin]). Complete remission (CR) rates were close at 74%, 78%, respectively (P = 0.32), as were percentages in CR (73%) and S (66%) rates; the latter outcomes were significantly better than IRS-I (CR: 56%, P , 0.001; S: 50%, P , 0.001). Central nervous system prophylaxis for group III patients with cranial ...

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