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The inhibitory effect of Oncovin (vincristine sulfate) on cell division was studied in human cell line NHIK 3025. Oncovin arrested the cells in metaphase at concentrations as low as 10(-3) mug/ml. At 8 X 10(-3) mug/ml and higher concentrations, the arrest was complete after 6 hr of treatment. The arrest was irreversible after exposure for 6 hr to 16 X 10(-3) mug Oncovin per ml. The X-ray radiosensitivity of aerobic cells of the same line pretreated with 16 X 10(-3) mug Oncovin per ml for 6 hr (Oncovin removed before irradiation) was found to be about equal to that of untreated cells. Even when present during irradiation, Oncovin did not exert any modifying effect on the radiosensitivity of either aerobic or extremely hypoxic cells.
RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer cells in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing. Giving everolimus together with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone may kill more cancer cells.. PURPOSE: This phase I trial is studying the side effects and the best dose of everolimus when given together with rituximab and combination chemotherapy in treating patients with newly diagnosed untreated diffuse large B-cell lymphoma. ...
Vincristine sulfate liposome injection (VSLI; Marqibo) was developed to optimize vincristine pharmacokinetics, dose-intensification, and target-tissue delivery.
Learn more about Marqibo® (vinCRIStine sulfate LIPOSOME injection) at MARQIBO.com. Marqibo® is for the treatment of adult patients with Philadelphia chromosome-negative (Ph‒) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies. This indication is based on overall response rate. Clinical benefit such as improvement in overall survival has not been verified.
Stage V FH, FA, or DA Wilms tumor: After bilateral conventional surgery (biopsy), patients with FH receive chemotherapy as in stratum 1 (dactinomycin IV weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate IV weeks 1-10, 12, 15, and 18) or 4 (dactinomycin IV weeks 0, 6, 12, 18, and 24; doxorubicin hydrochloride IV weeks 3, 9, 15, and 21; and vincristine sulfate VCR IV weeks 1-10, 12, 15, 18, 21, and 24). Patients with FA or DA receive chemotherapy as in stratum 7 (vincristine sulfate VCR IV weeks 1, 2, 4-8, 10-13, 18, and 24; cyclophosphamide sulfate (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; doxorubicin hydrochloride IV (beginning after CTX infusion) weeks 0, 6, 12, 18, and 24; and etoposide (VP-16) IV over 1 hour (beginning after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy ...
RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer cells in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing. Giving everolimus together with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone may kill more cancer cells.. PURPOSE: This phase I trial is studying the side effects and the best dose of everolimus when given together with rituximab and combination chemotherapy in treating patients with newly diagnosed untreated diffuse large B-cell lymphoma.. ...
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Treatment Strategies in Elderly Patients. In terms of induction strategies for treatment-naïve elderly patients, multiple regimens have been investigated in clinical trials. The University of Texas MD Anderson Cancer Center experience employing R-hyper-CVAD (rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone) alternating with high-dose methotrexate/cytarabine (R-MTX/AraC) showed a median failure-free survival (FFS) of 3 years in patients aged , 65 years versus 5.5 years in patients aged ≤ 65 years, revealing the inferior results achieved in the older patients. The University of Pennsylvania group reported the outcomes for 38 patients with MCL aged ≥ 60 years who received R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) or R-Hyper-CVAD with or without autologous stem cell transplantation (ASCT). This study demonstrated R-CHOP alone to be a less-effective treatment for older patients. The median progression-free survival ...
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Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) plus ponatinib appears to be superior to hyper-CVAD plus dasatinib for the frontline treatment of patients with Philadelphia chromosome-positive ALL.
The goal of this clinical research study is to learn if intensive chemotherapy (hyper-CVAD therapy) given in combination with liposomal vincristine (Marqibo),
CASI Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on the acquisition, development and commercialization of therapeutics for cancer and other medical needs. It operates through the development of targeted therapeutics for the treatment of cancer segment. Its product pipeline includes internal development of its lead drug candidate, ENMD-2076; MARQIBO, ZEVALIN and EVOMELA, and early-stage candidates in preclinical development. Its ENMD-2076 is an orally active, Aurora A/angiogenic kinase inhibitor with a kinase selectivity profile and multiple mechanisms of action. Its Marqibo is a sphingomyelin/cholesterol liposome-encapsulated, formulation of vincristine sulfate. Its ZEVALIN (ibritumomab tiuxetan) injection for intravenous use is a CD20-directed radiotherapeutic antibody. Its EVOMELA is an intravenous formulation of melphalan being investigated by Spectrum in the multiple myeloma transplant setting. Its pipeline also includes 2ME2 (2-methoxyestradial).
Marqibo (vincristine sulfate liposome injection) has been approved by the U.S. Food and Drug Administration to treat adults with a rare form of blood and bone m
The 10-year follow-up results from the LNH-98.5 trial, the first randomized study comparing the standard CHOP regimen to R-CHOP, confirm the benefits of adding rituximab to CHOP for the treatment of patients with DLBCL. The addition of rituximab improved PFS and OS rates in this patient population, with an overall increase of 16% versus CHOP alone. This difference was even more pronounced in patients exhibiting CR at the end of treatment (22%).. The patient cohort chosen for this trial was elderly DLBCL patients (60-80 years of age), a particularly challenging group to manage and treat. With the improvements in PFS and OS rates from the addition of rituximab to standard treatment regimens, a significant proportion of elderly patients experience long-term survival. At 10 years, more than 40% of the patients in our study were alive and in first CR. This emphasizes that the goal of treatment in elderly patients, as in younger patients, should be the cure of the lymphoma.. No plateau was reached for ...
BioAssay record AID 360916 submitted by ChEMBL: Cytotoxicity against vincristine-resistant mouse P388 cells in presence of 0.004 ug/mL vincristine.
Ive mentioned Hogan here and elsewhere a time or two. Hogan is an 8 year old Australian Shepherd who was in remission from Lymphoma for 4 years. [Since 2005.] This year has been a struggle keeping him in remission, the cancer popped up again June-ish and hes been treated with CCNU [http://www.chemocare.com/bio/ccnu.asp] He went back into remission until last Sunday. He got some diarrhea and his mom was giving him a neck massage and could feel his lymph nodes swollen in that area. It was confirmed at the emergency vet that he was out of remission. This all of course happened right before they were going out of town. I was scheduled to dog-sit for them way prior to this, and so they decided to continue with their trip plans. Hogan had a dose of vincristine on Tuesday. His parents left Wednesday. Hes been staying with me all week, coming in every day to work with me to have his lymph nodes checked. The swelling didnt go down like the doctor would have liked so he was put back on Prednisone. ...
December 17th, 2013, we knew very little about Childhood Cancer, the next day….we were forced to learn. September is Childhood Cancer Awareness month. Tomorrow, we will be at Nanaimo hospital. Olivia will be accessed. A nurse wearing a gown, gloves and a shield across her face will come into the room and hang a 2 ml bag of vincristine on an IV pole and she will push the button to start the drip. 4 weeks later we will be at BCCH. Olivia will be sedated and chemotherapy will be put into her spine. ...
As reported in The Lancet Oncology, Tilly et al found that the combination of polatuzumab vedotin, an antibody-drug conjugate targeting the CD79b component of the B-cell receptor, with immunochemotherapy showed high response rates in the phase II portion of a phase I/II study in previously untreated diffuse large B-cell lymphoma.. The phase II expansion of the study (conducted at 11 sites in the United States and France) included 66 patients with newly diagnosed disease. Patients received the polatuzumab vedotin recommended phase II dose of 1.8 mg/kg on day 2 of cycles 1 and 2 and on day 1 of subsequent 21-day cycles in combination with R-CHP (rituximab plus cyclophosphamide, doxorubicin, and prednisone; n = 45) or obinutuzumab plus CHP (G-CHP; n = 21) for a total of 6 or 8 cycles according to investigator preference.. Adverse Events. Among the patients receiving the phase II dose of polatuzumab vedotin, the most common adverse events of grade ≥ 3 were neutropenia (30%), febrile neutropenia ...
This study is currently recruiting participants. Verified May 2012 by UNC Lineberger Comprehensive Cancer Center First Received on November 2, 2010. &n…
Twelve patients with primary non-Hodgkins lymphomas of the CNS are described. Out of 5 CSF cytologies performed, 4 were positive. Radiotherapy was given to the tumour area in 3 patients, or to the whole brain in 5 patients. Four cases received radiotherapy to the spinal cord as well. Patients receiving ... read more whole CNS irradiation, including the spinal cord, seem to have a longer survival than patients with brain irradiation only. Out of the 5 patients with total brain irradiation, 2 showed a relapse in the spinal cord. It is suggested that therapy should be given not only to the tumour bearing areas, but should comprise the entire CNS. show less ...
Hana Biosciences, a biopharmaceutical company focused on advancing cancer care, recently announced that the US Food and Drug Administration (FDA) has granted orphan drug designation for vincristine sulfate liposomes injection (Marqibo) in the treatment of adult patients with acute lymphoblastic leukemia (ALL). 1
SILVER SPRING, Md. - The Food and Drug Administration has approved a new drug for treating a rare type of leukemia, the agency said Thursday.. The FDA approved South San Francisco, Calif.-based Talon Therapeutics Marqibo (vincristine sulfate liposome), an injectable drug for Philadelphia chromosome-negative acute lymphoblasic leukemia, or Ph-negative ALL. The drug, which consists of the widely used anti-cancer drug vincristine encased within a liposome - a drug delivery system made of a material similar to cell membranes - is approved for patients whose leukemia has returned twice or more or has progressed after two or more regimens of therapy.. According to the National Cancer Institute, part of the National Institutes of Health, more than 6,000 people will be diagnosed with ALL this year, and 1,440 will die from it. The disease is a rapidly progressing form of blood and bone marrow cancer more common in children than adults.. ...
This study aimed to systematically review and meta-analyze the value of pretransplant FDG-PET in predicting outcome after autologous stem cell transplantation (ASCT) in aggressive non-Hodgkin lymphoma. Medline was systematically searched, included studies were methodologically assessed and meta-analyzed, when possible. Overall methodological quality of included studies (n=11) was poor, with moderate ... read more risk of bias in the domains of study participation (n=7) and prognostic factor measurement (n=7), and high risk of bias in the domains of outcome measurement (n=10), and study confounding (n=11). In all aggressive non-Hodgkin lymphomas, pooled sensitivity and specificity were 54.0% and 73.1% in predicting treatment failure, and 54.5% and 68.7% in predicting death. Because of interstudy heterogeneity, additional subgroup analyses were performed. In newly diagnosed aggressive non-Hodgkin lymphoma, pooled sensitivity and specificity were 20.0% and 70.0% in predicting treatment failure, and ...
1 Hermans J, Drol AD, van Groningen K, et al. International Prognostic Index for aggressive non-Hodgkin lymphoma is valid for all malignancy grades. Blood. 1995l86:1460-1463.. 2 Alici S, Bavbek SE, Kaytan E, et al. Prognostic significance of the immunophenotype versus the International Prognostic Index in aggressive non-Hodgkin lymphoma. Clinical Lymphoma. 2003;4:52-55.. 3 De Santis V, Martelli M, Anticoli AP, et al. Localized stage I-IE aggressive non-Hodgkin lymphoma (NHL): results of prospective study with multimodality therapeutic approach. Anticancer Research. 2001;21:4169-4172.. 4 Bernard M, Cartron G, Rachieru P, et al. Long-term outcome of localized high-grade non-Hodgkin lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study. Haematologica. 2005:90:802-809.. 5 Roche. Study of MabThera in aggressive non-Hodgkin lymphoma in patients less than 60 years old halted two years early due to ...
TY - JOUR. T1 - Rituximab plus CHOP as an initial chemotherapy for patients with disseminated MALT lymphoma [4]. AU - Ennishi, Daisuke. AU - Yokoyama, Masahiro. AU - Mishima, Yuko. AU - Watanabe, Chie. AU - Terui, Yasuhito. AU - Takahashi, Shunji. AU - Takeuchi, Kengo. AU - Ikeda, Kazuma. AU - Tanimoto, Mitsune. AU - Hatake, Kiyohiko. PY - 2007/11. Y1 - 2007/11. UR - http://www.scopus.com/inward/record.url?scp=36048934446&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=36048934446&partnerID=8YFLogxK. U2 - 10.1080/10428190701636476. DO - 10.1080/10428190701636476. M3 - Article. C2 - 17990181. AN - SCOPUS:36048934446. VL - 48. SP - 2241. EP - 2243. JO - Leukemia and Lymphoma. JF - Leukemia and Lymphoma. SN - 1042-8194. IS - 11. ER - ...
PRIMARY OBJECTIVES: I. To determine the event-free survival (EFS) and overall survival (OS) of children with completely resected ependymoma treated with maintenance chemotherapy comprising vincristine sulfate, cisplatin, etoposide, and cyclophosphamide (VCEC) versus observation following post-operative conformal radiotherapy (cRT). SECONDARY OBJECTIVES: I. To estimate the EFS and OS of children with incompletely resected ependymoma who are unable to achieve a complete response (CR) by post-operative induction chemotherapy or by second surgery who are non-randomly assigned to cRT followed by VCEC. II. To further evaluate the EFS and OS of children with supratentorial classic ependymoma who achieve a complete resection at first or second resection or children who achieve a CR to short-course induction chemotherapy following first surgery. III. To determine the neurologic, neuropsychological, and endocrine long-term sequelae of surgery, cRT, and VCEC as compared to those patients treated on ...
The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL).. ALL is a rapidly progressing form of blood and bone marrow cancer that is more commonly diagnosed in children than adults. According to the National Cancer Institute, an estimated 6,050 men and women will be diagnosed with ALL and 1,440 will die from the disease this year.. Marqibo is approved for patients whose leukemia has returned (relapsed) two or more times, or whose leukemia has progressed following two or more regimens of anti-leukemia therapy. Marqibo contains vincristine, a commonly used anti-cancer drug, encased within a liposome, a drug delivery vehicle composed of material similar to that of cell membranes. It is an injection administered once a week by a health care professional.. "Marqibos approval demonstrates the FDAs commitment to the development and ...
Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation
Regimens that include multiple drugs may be referred to by an abbreviation after the nonproprietary names of the drugs have been provided at first mention (see also , Drug Abbreviations, and , Abbreviations, Clinical, Technical and Other Common Terms). Drug regimens used in oncology frequently are referred to by abbreviations of combinations of antineoplastic agents, but often the abbreviations are not derived from the INNs. For example, the letter O in MOPP is derived from Oncovin, the proprietary name for vincristine sulfate, and the A in ABVD is derived from Adriamycin, the proprietary name for doxorubicin hydrochloride. When the abbreviation
On Tuesday the 2nd Kyler had a Bone Marrow Biopsy, which confirmed his Leukemia diagnosis and on Wednesday the 3rd he had his MediPort put in and his first Lumbar Puncture with Cytarabine chemotherapy. Thursday the 4th he started a twice daily oral steroid Dexamethasone and had his first weekly IV Vincristine treatment. On Sunday the 7th he had Pegaspargase chemotherapy. He stayed in the hospital receiving daily oral medicine and a few platelet transfusions until Thursday the 11th. On that Thursday Kyler received his second dose of Vincristine and his second Lumbar Puncture this time with Methotrexate chemotherapy and he was released to go home that evening. He continued receiving his oral medicine twice a day and on each Monday he has been having check ups to make sure his levels are staying on par with where they should be. On Thursdays he has his weekly Vincristine treatments. ...
Newly diagnosed mantle cell lymphoma, admitted now to start chemotherapy. She will start treatment with hyperfractionated cyclophosphamide, vincristine,
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BioAssay record AID 464197 submitted by ChEMBL: Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.121 uM vincristine.
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We describe the effect and side effects in two children with cancer treated with intravenous methadone due to vincristine-induced neuropathy.
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