Here in the state of Florida, dozens of confirmed cases of the bacterial infection caused by Vibrio vulnificus occur annually, along with dozens more in the other Gulf states.. My guest, Infectious Disease specialist, a Forbes contributor, Judy Stone, MD said in a recent piece, "Infections from Vibrio vulnificus are a summer staple, and are increasing along with global warming.". Dr. Stone joined me to discuss Vibriosis caused by Vibrio vulnificus and the effects of warming seawaters on its presence in more parts of the world.. ...
Editorial Note: V. vulnificus was first described as a cause of human illness in 1979 (2 ). Although there is no national surveillance for infections caused by this pathogen, regional surveillance in four states along the Gulf Coast indicates an annual incidence for V. vulnificus infections of at least 0.6 per 1 million persons and a case-fatality rate of 22% (3). V. vulnificus, a free-living bacterium, occurs naturally in the marine environment, rather than as a result of pollution by human or animal fecal waste. This organism is commonly found in estuarine waters of the Gulf of Mexico, where it may contaminate oysters and other shellfish. Legal harvesting of oysters is limited to areas free of fecal contamination; however, V. vulnificus is ubiquitous in warm ocean waters, and oysters harvested from approved sites may be contaminated. Therefore, regardless of the source of the oysters, the potential for infection exists whenever raw oysters are consumed. Ingestion of raw or undercooked ...
TY - JOUR. T1 - Functional domains of a zinc metalloprotease from Vibrio vulnificus. AU - Miyoshi, Shin-ichi. AU - Wakae, H.. AU - Tomochika, K. I.. AU - Shinoda, S.. PY - 1997. Y1 - 1997. N2 - Vibrio vulnificus, an opportunistic human pathogen causing wound infection and septicemia, secretes a 45-kDa metalloprotease (V. vulnificus protease; VVP). A plasmid which carries the entire vvp gene subcloned into pBluescriptIIKS+ was transformed into Escherichia coil DH5α for overproduction of the protease. The 45-kDa recombinant protease (rVVP) was isolated from the periplasmic fraction of the transformant by ammonium sulfate precipitation followed by column chromatography on phenyl Sepharose. Biochemical characterization of the isolated rVVP showed that the recombinant protease was identical to that produced by V. vulnificus. When rVVP was incubated at 37°C, a 35-kDa fragment was generated through autoproteolytic removal of the C-terminal peptide. This 35-kDa fragment (rVVP-N) was found to have ...
During 1996-1997, a new Vibrio vulnificus biotype 3, which caused severe soft tissue infection after fishbone injury, emerged in Israel. We conducted a follow-up study from 1998 through 2005 to assess changing trends, outcomes, and molecular relatedness of the implicated strains. A total of 132 cases (71% confirmed and 29% suspected) of V. vulnificus biotype 3 infection were found. Most infections (95%) were related to percutaneous fish exposure, mainly tilapia (83%) or common carp (13%). Bacteremia, altered immune status, and history of ischemic heart disease were identified as independent risk factors for death, which reached a prevalence of 7.6%. Pulsed-field gel electrophoresis patterns of strains from 1998 through 2005 and from 1996 through 1997 showed a high degree of homogeneity and were distinct from those of V. vulnificus biotype 1. Infections caused by V. vulnificus biotype 3 continue affect the publics health in Israel.
Domain architecture and assignment details (superfamily, family, region, evalue) for gi|37676804|ref|NP_937200.1| from Vibrio vulnificus YJ016. Plus protein sequence and external database links.
A 3-year environmental and clinical Vibrio vulnificus survey using simple-sequence repeats typing shows that V. vulnificus biotype 3 constitutes ≈21% of the bacterium population in tested aquaculture ponds as opposed to ≈86% of clinical cases. Simple-sequence repeats proved to be a useful epidemiologic tool, providing information on the environmental source of the pathogen.
TY - JOUR. T1 - Enhancement of vascular permeability due to histamine-releasing effect of Vibrio vulnificus protease in rat skin. AU - Miyoshi, Shin-ichi. AU - Sugiyama, Katsumi. AU - Suzuki, Yukio. AU - Furuta, Hiroaki. AU - Miyoshi, Noriko. AU - Shinoda, Sumio. PY - 1987. Y1 - 1987. N2 - Vibrio vulnificus protease, which had been purified from the culture supernatant of a strain isolated from a septicemic human patient, enhanced hypodermic vascular permeability and formed hemorrhagic spot caused by tissue destruction in a dose-dependent manner within a range of 0.3-10.0 μg when injected intradermally (i.d.) into rat dorsal skin. Enhancement of permeability was observed within 2 min, and the permeability-enhancing reaction terminated at 10 min after the injection. This reaction was blocked by simultaneous injection of an antihistamine, diphenhydramine, suggesting that the permeability-enhancing reaction of V. vulnificus protease was due to histamine release in vivo. Hemorrhage caused by V. ...
Coloured scanning electron micrograph (SEM) of Vibrio vulnificus, Gram-negative, motile, curved rod-shaped bacteria (prokaryote). It is a human pathogen and causes an infection often after eating seafood, especially oysters. The bacterium occurs in marine environments such as estuaries, brackish ponds or coastal areas and it is highly salt tolerant. It is often present in contaminated waters and heated waters such as thermal or volcanic springs. Vibrio vulnificus can also enter the body through open wounds when swimming or wading, or via puncture wounds from the spines of fish such as tilapia. Symptoms include vomiting, diarrhoea, abdominal pain, decreased blood pressure and a blistering dermatitis. Severe symptoms and even death can occur if the bacterium enters the bloodstream (more common in people with compromised immune systems or liver disease). Magnification: x5,000 when shortest axis printed at 25 millimetres. - Stock Image C032/2229
According to Centers For Disease Control and Prevention, Vibrio vulnificus is a kind of bacteria that may cause infections from eating raw or undercooked seafood. These infections can also happen through an open wound if the wound comes into contact with raw or undercooked seafood, its drippings or with saltwater.. "One species, Vibrio vulnificus, can even cause life-threatening wound infections. Many people with Vibrio vulnificus infection require intensive care or limb amputations, and about one in five people with this infection die, sometimes within a day or two of becoming ill," the CDC says.. "Some Vibrio vulnificus infections lead to necrotizing fasciitis, a severe infection in which the flesh around an open wound dies. Some media reports call this kind of infection "flesh-eating bacteria," even though necrotizing fasciitis can be caused by more than one type of bacteria." ...
Vibrio vulnificus, a recently described strain of the halophilic Vibriospecies, was isolated from the blood of a 73-year-old man, who developed rapidly progressive wound infection and fatal...
Author Summary Vibrio vulnificus causes disease both by infection of wounds from seawater and by consumption of contaminated foods, especially oysters. Wound infection results in necrotizing fasciitis and edema in extremities with mortality of ∼25% as the incidence of septicemia is low. Contaminated food consumption by contrast can lead to highly invasive infections that progress rapidly from an intestinal infection to primary septicemia. Case-fatality rates are ≥50%, with rates as high as 100% in individuals who receive no antibiotic therapy. The aim of this study is to elucidate virulence mechanisms of food-borne infection of the most highly virulent strains of V. vulnificus. We developed a novel intragastric infection model for a highly virulent clinical isolate from Korea in which we can observe the bacterial load in live mice and applied this to study of wild type and strains genetically altered to delete genes for two secreted cytotoxins. Using this model, we show that both the multifunctional
Of all concerns which face the shellfish industry, none are currently as critical as the presence of Vibrio vulnificus in oysters. In fact, 95% of all deaths resulting from seafood consumption are caused by this bacterium (8). V. vulnificus is part of the normal bacterial flora of estuarine waters and occurs in high numbers in molluscan shellfish. Fatality rates of over 60%, with median incubation times to onset of symptoms being as low as 7 h, have been reported (8). Between 1989 and 2000, 274 cases involving oyster ingestion occurred in the United States, of which 142 (52%) were fatal. Most (∼95%) cases occur in individuals who are immunocompromised, have diabetes, or have underlying diseases/syndromes which result in elevated serum iron levels, primarily liver cirrhosis secondary to alcohol abuse/alcoholism (7). Additionally, most (∼95%) cases occur in males, since females are protected from the V. vulnificus endotoxin by estrogen (5). Recent evidence also suggests that only certain ...
Virulence of Vibrio vulnificus has been strongly associated with encapsulation and an opaque colony morphology. Capsular polysaccharide was purified from a whole-cell, phosphate-buffered saline-extracted preparation of the opaque, virulent phase of V. vulnificus M06-24 (M06-24/O) by dialysis, centrifugation, enzymatic digestion, and phenol-chloroform extraction. Nuclear magnetic resonance spectroscopic analysis of the purified polysaccharide showed that the polymer was composed of a repeating structure with four sugar residues per repeating subunit: three residues of 2-acetamido-2,6-dideoxyhexopyranose in the alpha-gluco configuration (QuiNAc) and an additional residue of 2-acetamido hexouronate in the alpha-galactopyranose configuration (GalNAcA). The complete carbohydrate structure of the polysaccharide was determined by heteronuclear nuclear magnetic resonance spectroscopy and by high-performance anion-exchange chromatography. The 1H and 13C nuclear magnetic resonance spectra were completely ...
The recent emergence of the human-pathogenic Vibrio vulnificus in Israel was investigated by using multilocus genotype data and modern molecular evolutionary analysis tools. We show that this pathogen is a hybrid organism that evolved by the hybridization of the genomes from 2 distinct and independent populations. These findings provide clear evidence of how hybridization between 2 existing and nonpathogenic forms has apparently led to the emergence of an epidemic infectious disease caused by this pathogenic variant. This novel observation shows yet another way in which epidemic organisms arise ...
The Florida Department of Health in Brevard County (DOH- Brevard) urges Floridians and visitors to the area to take precautions to avoid exposure to Vibrio vulnificus.
... , Noboru Nakasone, Yasunori Ogura, Naomi Higa, Claudia Toma, Yukiko Koizumi, Toshihi
X-MOL提供的期刊论文更新,Estuaries and Coasts--Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk.,Reem Deeb,Daniel Tufford,Geoffrey I Scott,Janet Gooch Moore,Kirstin Dow
Vibrio vulnificusis a gram-negative bacterium that can cause serious wound infections, septicemia, and diarrhea. It is the leading cause of shellfish-associated deaths in the United States. Infections due toV. vulnificusare most common in individuals
Thanks FOSL for getting her interview out……..We are presently looking at all the bacterial angles associated to these health issues being reported. One bacterium that everyone should take notice of is the Vibrio vulnificus (flesh eating strain of Vibrio). "Vibrio vulnificus is a proteobacteria and a pathogen of humans. It causes wound infections, gastroenteritis, or primary septicemia (blood poisoning). Vibrio vulnificus causes disease in individuals who eat contaminated seafood (raw or undercooked oysters or have an open wound that is exposed to seawater." There have been several deaths due to this rare bacterial strain of Vibrio in the gulf region over the past couple of months. There are over 100 documented strains of this bacteria Vibrio with the possibility of thousands that have yet to be discovered. Back in June of this year the New York Times was reporting how scientist feared a possible bacterial plague erupting due to the Gulf spill. Are we now seeing a super bug? Is it an ...
A story map has been created to describe the different Vibrio Predictive Models produced by NCCOS. These predictive models help ensure oysters are harvested when they are safer to eat, assisting coastal managers and oyster growers in oyster harvest decision making nationwide.. Vibrio spp. are bacteria that occur naturally in our coastal waters. The majority of the cases annually are associated with Vibrio parahaemolyticus, usually resulting in self limiting gastroenteritis from the consumption of raw seafood. Vibrio vulnificus is another species of Vibrio bacteria that can cause human illness. Although cases are rare, Vibrio vulnificus infections stemming from water contact with open wounds or consumption can be serious and sometimes fatal.. The story map presents an assortment of predictive models and weather related tools to address issues surrounding safe harvest of shellfish around the nation. In partnership with the US Food and Drug Administration, state and academic partners, NOAA is ...
1Department of Marine Biology, Texas A&M University at Galveston, Galveston, Texas 77551 2Department of Pathology and Otolaryngology, The University of Texas Medical Branch, Galveston, Texas 77555 Next Section ABSTRACT Randomly amplified polymorphic DNA (RAPD) PCR was used to analyze the temporal and spatial intraspecific diversity of 208 Vibrio vulnificus strains isolated from Galveston Bay water and oysters at five different sites between June 2000 and June 2001. V. vulnificus was not detected during the winter months (December through February). The densities of V. vulnificus in water and oysters were positively correlated with water temperature. Cluster analysis of RAPD PCR profiles of the 208 V. vulnificus isolates revealed a high level of intraspecific diversity among the strains. No correlation was found between the intraspecific diversity among the isolates and sampling site or source of isolation. After not being detected during the winter months, the genetic diversity of V. vulnificus ...
The identification of factors that contribute to the pathogenesis of V. vulnificus has been especially challenging. Several bacterial cell-associated and -secreted proteins have been implicated in the ability of V. vulnificus to cause disease, but only the presence and amount of the exopolysaccharide capsule, the presence of a siderophore to acquire iron from transferring, and a functional flagellar biogenesis system have been positively correlated with virulence (28, 52, 74, 76, 77). The precise roles of the many toxins and enzymes that are secreted remain to be defined (7, 64, 72, 75). Disruption of individual genes encoding proteins that have potent in vitro pharmacological activities, including a cytolysin (72), a metalloprotease (50), and an elastolytic protease (16, 27), has shown that none of these are essential virulence determinants, since the mutants are just as pathogenic as the parental strains. In fact, a metalloprotease-deficient mutant was found to be even more virulent than ...
The CDC data on vibriosis includes all vibrio species except cholera, so its unclear how much of the increase in the past five years is due to infection by the flesh-eating bacteria that can cause death. [...] in a June 2012 letter to BP, Dr. Thomas Miller, the deputy director for medical affairs at the Alabama Department of Public Health stated, There is no epidemiological evidence to indicate increased rates of Vv (Vibriosis vulnificus) infections. In response to the EcoHealth article by Arias, Tao and Bullard, the U.S. Coast Guards on-scene coordinator for the oil spill management asked the National Oceanic and Atmospheric Administration to review the risk of Vibrio vulnificus infection due to tar ball exposure. In regard to the paper by Tao, Aris and Bullard, the NOAA report said, It is not surprising to find high levels of bacteria associated with these oil sources, although why V. vulnificus is present at such high levels is an intriguing question....The implications to public health also
Authorities believe that vibriosis infection and spectic shock is the cause. It may not have been completely the parasites fault, as doctors believe that years of alcohol abuse caused his body to become weakened.. "We present a case of Vibrio vulnificus septic shock and cellulitis in a patient with chronic liver disease that occurred after obtaining a leg tattoo with subsequent seawater exposure in the Gulf of Mexico," the summary from the British Medical Journal states. "Initial suspicion for V. vulnificus was high and he was started on empiric doxycycline and ceftriaxone at admission. Blood and wound cultures grew oxidase positive and comma-shaped Gram-negative rods ultimately confirmed to be V. vulnificus. Despite aggressive initial treatment, the patient developed septic shock and died. This case highlights the association of chronic liver disease and high mortality associated with infections of V. vulnificus. Health providers should remain vigilant for V. vulnificus infections in patients ...
Many clinical microbiology laboratories require that their identification systems perform at an accuracy of 90% or better, and many require a 95% accuracy. The Phoenix system accurately identifies isolates of the family Enterobacteriaceae only 89% of the time. Even with a weighted set of organisms, the accuracy is 89%.. In the only other published study of the Phoenix system that used conventional biochemicals for a reference method, Colodner et al. reported 90.2% accuracy when identifying 51 isolates of Vibrio vulnificus biotype 3 as Vibrio vulnificus (2). Because the present study did not include any biogroup 3 isolates, it is not known how the present results compare to those of Colodner and coworkers (2).. Several evaluations that used other commercial identification products as the reference method have been performed. Endimiani et al. tested 136 nonfermenting gram-negative bacilli and reported 95.6% agreement between the Phoenix 100 ID/AST system and the ATB/ID32GN system (bioMérieux, ...
Vibrio parahaemolyticus (Vp) and Vibrio vulnificus (Vv) are naturally occurring estuarine bacteria and are the leading causes of seafood-associated infections and mortality in the USA. Though multiple-antibiotic resistant Vp and Vv have been reported resistance patterns in vibrios are not as well documented as other food-borne bacterial pathogens. Salinity relaying (SR) is a Post-Harvest Processing (PHP) treatment to reduce the abundance of these pathogens in shellfish harvested during the warmer months. The purpose of this study was to evaluate the antimicrobial susceptibility (AMS), pathogenicity and genetic profiles of Vp and Vv recovered from oysters during an oyster relay study ...
[...] the night following a fishing trip on Texas mid-coast, the elderly angler noticed the wound was beet red, swelling and hurt like the dickens. [...] after surgeries to remove the infected tissue, skin grafts and rehabilitation, the man survived his encounter with the tiny organism that arguably poses more serious danger to coastal anglers and others who recreate in marine waters than any other. Considering that hundreds of thousands of Texans annually swim, boat, fish or otherwise are exposed to marine water potentially holding vibrio vulnificus, odds of becoming one of the 20-25 Texans who, in an average year, suffer infections caused by the bacteria are laughably small - unless you, a family member or friend is one of those two dozen. The best thing people can do is to have a heightened level of awareness about vibrio vulnificus, understand what to look for and how important it is to take immediate action if they suspect they have been infected, said Burns, chief of staff of DeTar Health
Author(s): Lim, Ket-Cheong; Tan, Yin-Ling; Wu, Chin-Chu; Lin, Li-Wei | Abstract: Two cirrhotic patients with unexplained abdominal pain deteriorated rapidly and fatally after presenting to our emergency department. Abdominal computed tomography in both patients showed
Vibrio vulnificus is a causative agent of serious food-borne diseases in humans related to the consumption of raw seafood. It secretes a metalloprotease that is associated with skin lesions and serious hemorrhagic complications. In this study, we purified and characterized an extracellular metalloprotease (designated as vEP) having prothrombin activation and fibrinolytic activities from V. vulnificus ATCC 29307. vEP could cleave various blood clotting-associated proteins such as prothrombin, plasminogen, fibrinogen, and factor Xa, and the cleavage could be stimulated by addition of 1 mM Mn2+ in the reaction. The cleavage of prothrombin produced active thrombin capable of converting fibrinogen to fibrin. The formation of active thrombin appeared to be transient, with further cleavage resulting in a loss of activity. The cleavage of plasminogen, however, did not produce an active plasmin. vEP could cleave all three major chains of fibrinogen without forming a clot. It could cleave fibrin polymer ...
Ph.D. - Texas A&M University. Research Interests:. My recent research has focused on microbial aspects of fresh and marine water quality and animal sources of fecal contamination affecting watersheds. This involves characterizing (antibiotic resistance and carbon source profiling) bacteria normally found in the intestinal tracts of animals such as E. coli and enterococci, using PCR and qPCR to detect host-specific genetic markers, and examining persistence of fecal bacteria in soils and sediments, as well as surface waters. We are presently conducting experiments to determine how well enterococci can survive in soils and later contaminate waters, under a range of environmental conditions. My students are also sampling a creek and an artificial lake for water quality and characterizing geese fecal bacteria. I have also been working with the estuarine pathogen Vibrio vulnificus, which causes severe wound infections, comparing environmental strains with clinical strains isolated from patients, for ...
Doctors diagnosed the man with septic shock due to an infection with vibrio vulnificus, potentially deadly bacteria found in certain coastal waters that are present in higher concentrations in warmer months.. According to the Centers for Disease Control and Prevention, vibrio causes 80,000 illnesses and 100 deaths each year in the US. Most people become infected by eating raw seafood, particularly oysters, but exposing open wounds to brackish or salt water can also put a person at risk of infection.. People with compromised immune systems, especially those with chronic liver disease, are more likely to get vibriosis.. According to the case report, the patient had a history of cirrhosis of the liver and drank six 12-ounce beers daily.. Within 24 hours of admission, his condition declined with progressive septic shock and multi-organ system failure. Doctors put him on life support and treated him with aggressive antibiotics. Despite initial improvement, he continued to suffer complications related ...
Please note: Vibrio vulnificus bacteria, also called flesh eating disease, is a naturally occurring bacteria in some of Floridas waters. This bacteria can be lethal, especially when contracted by individuals with compromised immune systems. Concentrations of the bacteria are higher in the mouths of rivers near oceans. The bacteria is most dangerous when ingested in raw seafood but recent deaths are attributed to individuals who have waded in water with broken skin. Beach goers are urged to use caution and consult a physician if you suspect you have come in contact with the bacteria.. ...
After a King County man was diagnosed with a rare and sometimes fatal bacterial infection, Vibrio vulnificus, public health officials are investigating the possibility that the bacteria came from fish purchased locally. Public Health cautions anyone who has come into contact with raw fish to seek medical care if they develop symptoms of infection. Read the […]. Read More ...
Dr. Alis research interests include epidemiology and ecology of vibrio cholerae in Bangladesh, emergence of vibrio vulnificus in aquaculture reservoirs, and the genetic and physiologic analyses of rugose variant of V. cholerae.. ...
Vibrio vulnificus, one of a dozen species of this Vibrio bacteria, has been making headlines this summer. Its found in the coastal waters according CDC.
Asim K. Bej, Ph.D., a professor in the UAB Department of Biology, and his research team have developed a new method to test for Vibrio vulnificus, a b...
As the planet continues to warm, Vibrio vulnificus could be the next public health threat that rapidly grows from a whisper to a shout.
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진행성 위암의 경우, 근치 목적의 위절제술을 받더라도 상당수의 환자에서는 암이 재발하여 결국은 환자가 사망에 이르게 된다. 재발을 줄이기 위해 수술 후 보조화학요법이 적지 않게 시도됐으나 그 치료효과를 정확히 평가할 수 있는 잘 계획된, 대규모 3상 임상시험이 없는 상황이었다. CLASSIC 연구는 이 시급한 질문에 답하기 위해 2004년에 우리 연구진이 제안했고, 로슈와 사노피 두 회사를 설득함으로써 시행됐다. 이 연구는 우리나라는 물론 중국과 타이완의 여러 병원들이 참여했고, 2005년부터 2009년까지 1,035명의 위암환자가 D2 절제술을 받은 뒤 대조군과 8회의 XCELOX 보조화학요법을 받는 군으로 무작위 배정됐다. 이 연구의 1차 endpoint는 3년 무병생존율이었고, 2012년에 XELOX 보조요법군에서 재발 risk가 44% 감소함을 보고했다 (Bang YJ et al., Lancet2012;379:315-21). ...
Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ ...
Polacy żyją coraz bardziej ekologicznie. Aż 66 proc. z nas stosuje w domach przyjazne dla środowiska rozwiązania. Jak zorganizować sobie wakacje w zgodzie z naturą?
12 małp (1995) - Jest rok 2035. Nieznany wirus niszczy ludzkość. Tylko 1% populacji uchodzi z życiem. Ludzie żyją pod ziemią. Więzień James Cole zostaje wysłany w przeszłość do roku 1996, aby zebrać...
Polacy żyją coraz bardziej ekologicznie. Aż 66 proc. z nas stosuje w domach przyjazne dla środowiska rozwiązania. Jak zorganizować sobie wakacje w zgodzie z naturą?
Here are some up to date pictures of my Build. still have a bit lift but hopefully I have it ready for the MUD with in a couple of weeks. 1992 YJ Chevy 350 700r4 trany, NP 241 T-Case 2 Body lift
Background: Vibrio and Aeromonas species, which can cause necrotizing fasciitis and primary septicemia, are members of the Vibrionaceae family and thrive in aquatic environments. Because the clinical symptoms and signs of necrotizing fasciitis and sepsis caused by these two bacteria are similar, the purposes of this study were to describe the clinical characteristics of Vibrio vulnificus and Aeromonas infections, to analyze the risk factors for death, and to compare the effects of surgical treatment on the outcome. Methods: The cases of thirty-two patients with necrotizing soft-tissue infections and sepsis caused by Vibrio vulnificus (seventeen patients) and Aeromonas species (fifteen patients) were retrospectively reviewed over a four-year period. Surgical débridement or immediate limb amputation was initially performed in all patients. Demographic data, underlying diseases, laboratory results, and clinical outcome were analyzed for each patient in both groups. Results: Six patients in the ...
We present a case of a 40-year-old man with decompensated alcoholic liver cirrhosis presenting with atraumatic cellulitis of one extremity and severe sepsis that rapidly progressed to compartment syndrome despite broad-spectrum antibiotics. Local cultures following debridement revealed Vibrio vulnificus, and subsequent history revealed consumption of raw oysters 48 h before presentation. Our case points out the unique susceptibility of those with cirrhosis and elevated iron saturation to Vibrio septicaemia, as well as the rapidity and severity of the disease progression.
Heterogeneity among isolates of Vibrio vulnificus recovered from eels (Anguilla anguilla) in Denmark. Isolation of Vibrio alginolyticus and Vibrio splendidus from aquacultured carpet shell clam (Ruditapes decussatus) larvae associated with mass mortalities
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...