Vesicular stomatitis virus of the New Jersey serotype (VSV-NJ) causes vesicular disease in cattle, pigs, and horses throughout the Americas. Vesicular disease is clinically indistinguishable from foot-and-mouth disease (FMD). Therefore, outbreaks of vesicular disease in FMD-free areas must be rapidly diagnosed by laboratory methods and affected farms must be quarantined until laboratory results confirm the absence of FMD. Diagnosis is currently performed in high-containment (biosafety level 3) laboratories by using complement fixation and virus isolation in tissue culture. We describe here an alternative method for the detection of VSV-NJ RNA in clinical samples. This method includes a rapid acid guanidine-phenol RNA extraction procedure coupled with a one-tube polymerase chain reaction (PCR) using reverse transcriptase. By using this test, we were able to detect the largest number of positive samples (53 of 58), followed by complement (48 of 58) and isolation in tissue culture (43 of 58). The ...
A full-length cDNA copy of the phosphoprotein (NS) mRNA of vesicular stomatitis virus (New Jersey serotype) was inserted into pGEM4 vector downstream of the promoter for bacteriophage SP6 RNA polymerase. Transcription of the cDNA in vitro resulted in the synthesis of NS mRNA, which was subsequently translated into NS protein in a cell-free rabbit reticulocyte system. The biological activity of the expressed NS protein was demonstrated by in vitro synthesis of mRNA by transcription-reconstitution with purified viral L protein and N-RNA template. Deletion mapping of the NS gene defined a specific domain between amino acid residues 213 and 247, which was essential for in vitro transcription. Removal of the COOH-terminal 21 amino acids, on the other hand, did not have a significant effect on transcription. This domain appears to be involved in efficient binding of NS protein to the N protein-RNA template. ...
Vesicular stomatitis virus (VSV), a prototype of the Rhabdoviridae family, contains a single surface glycoprotein (G) that is responsible for attachment to cells and mediates membrane fusion. Working with the Indiana serotype of VSV, we employed a reverse genetic approach to produce fully authentic recombinant viral particles bearing lethal mutations in the G gene. By altering the hydrophobicity of the two fusion loops within G, we produced a panel of mutants, W72A, Y73A, Y116A, and A117F, that were nonfusogenic. Propagation of viruses bearing those lethal mutations in G completely depended on complementation by expression of the glycoprotein from the heterologous New Jersey serotype of VSV. The nonfusogenic G proteins oligomerize and are transported normally to the cell surface but fail to mediate acid pH-triggered membrane fusion. The nonfusogenic G proteins also interfered with the ability of wild-type G to mediate fusion, either by formation of mixed trimers or by inhibition of trimer ...
Vesiculoviruses enter cells by membrane fusion, driven by a large, low‐pH‐induced, conformational change in the fusion glycoprotein G that involves transition from a trimeric pre‐fusion toward a trimeric post‐fusion state via monomeric intermediates. Here, we present the structure of the G fusion protein at intermediate pH for two vesiculoviruses, vesicular stomatitis virus (VSV) and Chandipura virus (CHAV), which is responsible for deadly encephalopathies. First, a CHAV G crystal structure shows two intermediate conformations forming a flat dimer of heterodimers. On virions, electron microscopy (EM) and tomography reveal monomeric spikes similar to one of the crystal conformations. In solution, mass spectrometry shows dimers of G. Finally, mutations at a dimer interface, involving fusion domains associated in an antiparallel manner to form an intermolecular β‐sheet, affect G fusion properties. The location of the compensatory mutations restoring fusion activity strongly suggests that ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Kathrina Quinn, Melinda A. Brindley, Melodie L. Weller, Nikola Kaludov, Andrew Kondratowicz, Catherine L. Hunt, Patrick L. Sinn, Paul B. McCray, Colleen S. Stein, Beverly L. Davidson, Ramon Flick, Robert Mandell, William Staplin, Wendy Maury, John A. Chiorini ...
Here you go! Hopefully thatll help you to work out whether youve been bitten by a sand-flea or not. Is A Sand-Flea Bite Dangerous? Not particularly, no. However, sand-fleas can carry dangerous viruses, such as the Chandipura virus (similar to Rabies). Despite being painful and itchy, sand-flea bites are usually relatively harmless and will start … Read more ...
TY - JOUR. T1 - A human case of encephalitis associated with vesicular stomatitis virus (Indiana serotype) infection. AU - Quiroz, E.. AU - Moreno, N.. AU - Peralta, P. H.. AU - Tesh, R. B.. PY - 1988. Y1 - 1988. N2 - This paper describes a case of severe encephalitis in a 3-year-old Panamanian boy infected with the Indiana serotype of vesicular stomatitis virus. The virus was recovered from the childs throat on the fifth day of illness and a rise in neutralizing antibody titer was demonstrated in paired serum specimens. This is the second report of childhood encephalitis associated with vesicular stomatitis virus infection. These suggest that infection with vesicular stomatitis viruses may cause severe disease. Human infection with vesicular stomatitis viruses is common throughout the tropical Americas.. AB - This paper describes a case of severe encephalitis in a 3-year-old Panamanian boy infected with the Indiana serotype of vesicular stomatitis virus. The virus was recovered from the ...
TY - JOUR. T1 - Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs. AU - Leblanc, Amy K.. AU - Naik, Shruthi. AU - Galyon, Gina D.. AU - Jenks, Nathan. AU - Steele, Mike. AU - Peng, Kah Whye. AU - Federspiel, Mark J.. AU - Donnell, Robert. AU - Russell, Stephen J.. PY - 2013/12/1. Y1 - 2013/12/1. N2 - VSV-IFNβ-NIS is a novel recombinant oncolytic vesicular stomatitis virus (VSV) with documented efficacy and safety in preclinical murine models of cancer. To facilitate clinical translation of this promising oncolytic therapy in patients with disseminated cancer, we are utilizing a comparative oncology approach to gather data describing the safety and efficacy of systemic VSV-IFNβ-NIS administration in dogs with naturally occurring cancer. In support of this, we executed a dose-escalation study in purpose-bred dogs to determine the maximum tolerated dose (MTD) of systemic VSV-hIFNβ-NIS, characterize the adverse event ...
Although vesicular stomatitis virus (VSV) neurovirulence and pathogenicity in rodents have been well studied, little is known about VSV pathogenicity in non-human primates. To address this question, we measured VSV viremia, shedding, and neurovirulence in macaques. Following intranasal inoculation, …
Vaccines based on live viruses are attractive because they are immunogenic, cost-effective, and can be delivered by multiple routes. However, live virus vaccines also cause reactogenic side effects such as fever, myalgia, and injection site pain that have reduced their acceptance in the clinic. Several recent studies have linked vaccine-induced reactogenic side effects to production of the pro-inflammatory cytokine interleukin-1β (IL-1β) in humans. Our objective was therefore to determine whether IL-1β contributed to pathology after immunization with recombinant vesicular stomatitis virus (rVSV) vaccine vectors, and if so, to identify strategies by which IL-1β mediated pathology might be reduced without compromising immunogenicity. We found that an rVSV vaccine induced local and systemic production of IL-1β in vivo, and that accumulation of IL-1β correlated with acute pathology after rVSV immunization. rVSV-induced pathology was reduced in mice deficient in the IL-1 receptor Type I, but the IL-1R
The particle-bound RNA polymerase activity of vesicular stomatitis virus (VSV) can be demonstrated in vivo. Linear synthesis of viral RNA persists for 5 to 6 hours at 34°C in infected monolayers of chick embryo cells treated with cycloheximide and actinomycin D to block synthesis of protein and cell-specific RNA. At least 55 percent of the RNA made under these conditions is complementary to virion RNA. RNA synthesis mediated by VSV polymerase activity is inhibited in cells first treated with chick-derived interferon or polyriboinosinate• polyribocytidylate, but not by mouse interferon. The RNA product of VSV polymerase activity is present throughout the cytoplasm, and its synthesis is inhibited by the interferon system, as judged by autoradiographs that show the physical distribution, in cells, of RNA produced by virion polymerase in the absence of translation-a demonstration of the transcription product of the viral genome. ...
The effects of formalin on the infectivity and immunogenicity of vesicular stomatitis virus (VSV) serotype Indiana were investigated. We found that formalin inactivation of VSV prevents infection of Vero cells in a concentration- and time-dependent manner, as shown by fluorometric cell analysis and inhibition of plaque formation. Inactivated VSV failed to induce significant cytotoxic T-lymphocyte responses in vivo or after restimulation in vitro. In contrast, the early immunoglobulin M (IgM) response, which is T help independent in the VSV system, was unaltered, suggesting normal antigenicity for and induction of B cells. However, no switch to IgG occurred, demonstrating failure of induction of T help. If cross-reactive T help was provided by previous infection with a second serotype of VSV (New Jersey), the IgG response was almost completely restored, confirming that the absence of IgG was due to lack of T help. A formalin-treated preparation of glycoprotein of VSV led to a delayed but otherwise normal
Viruses have been used as transsynaptic tracers, allowing one to map the inputs and outputs of neuronal populations, due to their ability to replicate in neurons and transmit in vivo only across synaptically connected cells
A stable cell line expressing a complementary DNA clone encoding the vesicular stomatitis virus glycoprotein fused and formed polykaryons at pH 5.5. The formation of polykaryons was dependent on the presence of glycoprotein anchored at the cell surface and could be prevented by incubation of cells with a monoclonal antibody to the glycoprotein. Fusion occurred at a pH 0.5 unit lower than that observed for cells infected with vesicular stomatitis virus. ...
TY - JOUR. T1 - Lysis of target cells infected with vesicular stomatitis virus (VSV) in the presence of tunicamycin by anti-VSV cytotoxic T lymphocytes. AU - Harris, D. T.. AU - Hale, A. H.. AU - Lefrancois, L.. PY - 1981/1/1. Y1 - 1981/1/1. N2 - We have analyzed the requirement for the expression of the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) on target cells for recognition and lysis by anti-VSV cytotoxic T lymphocytes (CTL). In addition, we have attempted to determine if the carbohydrate moieties on the G protein are required for recognition and lysis by anti-VSV CTL. When VSV (Orsay) is grown at 30°C in the presence of tunicamycin (TM), glycosylation of G protein is inhibited; however, nonglycosylated G protein is found on the surface of the cell and active virus particles are produced. In contrast, VSV (Orsay) grown at 39°C in the presence of TM produces low titers of virus and the presence of G protein on the surface of cells is not detectable. The ...
Polyclonal and monoclonal antibodies were raised against a synthetic peptide containing the 15 carboxy-terminal amino acids (497-511) of vesicular stomatitis virus glycoprotein (VSV-G). The polyclonal antibodies (alpha P4) reacted with epitopes distributed along the 15-residue peptide, whereas the m …
Creative Biolabs provides Human anti-vesicular stomatitis virus octapeptide (VSV8) (aa 52-59) T cell receptor, pCDTCR1 product for Biopharmaceutical research,preclinical and clinical trials.
Plasmid pHEF-VSVG from Dr. Sergey Kasparovs lab contains the insert Vesicular Stomatitis Virus Glycoprotein and is published in Physiol Genomics. 2003 Feb 6. 12(3):221-8. This plasmid is available through Addgene.
DOI: https://doi.org/10.3389/fmicb.2019.01057 Interpretive Summary: In this publication, we reviewed the biological effects of Interleukin 6 (IL-6) during the response to a viral infection. Interestingly, although IL-6 seems to play an essential role during the immune response against different viral entities, we found evidence that in some occasions, an unbalance during the immune response can produce the up-regulation of IL-6, compromising viral clearance, and ultimately promoting viral persistence. All different mechanisms regarding the by how IL-6 might negatively affect the immune response against viruses are covered in this opinion report. Technical Abstract: Our recently published research on the characterization of vesicular stomatitis virus (VSV) pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the acute phase of infection (Velazquez-Salinas et al., 2018). This upregulation was observed during infection with a highly virulent VSV strain, ...
Nipah virus (NiV) is a highly pathogenic zoonotic agent in the family Paramyxoviridae that is maintained in nature by bats. Outbreaks have occurred in Malaysia, Singapore, India, and Bangladesh and have been associated with 40 to 75% case fatality rates. There are currently no vaccines or postexposure treatments licensed for combating human NiV infection. Four groups of ferrets received a single vaccination with different recombinant vesicular stomatitis virus vectors expressing: Group 1, control with no glycoprotein; Group 2, the NiV fusion protein (F); Group 3, the NiV attachment protein (G); and Group 4, a combination of the NiV F and G proteins. Animals were challenged intranasally with NiV 28 days after vaccination. Control ferrets in Group 1 showed characteristic clinical signs of NiV disease including respiratory distress, neurological disorders, viral load in blood and tissues, and gross lesions and antigen in target tissues; all animals in this group succumbed to infection by day 8. Importantly
In a previous study we demonstrated that vesicular stomatitis virus (VSV) can be used as a vector to express a soluble protein in mammalian cells. Here we have generated VSV recombinants that express four different membrane proteins: the cellular CD4 protein, a CD4-G hybrid protein containing the ectodomain of CD4 and the transmembrane and cytoplasmic tail of the VSV glycoprotein (G), the measles virus hemagglutinin, or the measles virus fusion protein. The proteins were expressed at levels ranging from 23-62% that of VSV G protein and all were transported to the cell surface. In addition we found that all four proteins were incorporated into the membrane envelope of VSV along with the VSV G protein. The levels of incorporation of these proteins varied from 6-31% of that observed for VSV G. These results suggest that many different membrane proteins may be co-incorporated quite efficiently with VSV G protein into budding VSV virus particles and that specific signals are not required for this ...
The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viral and other microbial pathogens in their genome (so-called chimeric virus vaccines). Many such viral vector vaccines are now at various stages of clinical evaluation. Here, we introduce an attenuated form of recombinant vesicular stomatitis virus (rVSV) as a potential chimeric virus vaccine for HIV-1, with implications for use as a vaccine vector for other pathogens. The rVSV/HIV-1 vaccine vector was attenuated by combining two major genome modifications. These modifications acted synergistically to greatly enhance vector attenuation and the resulting rVSV vector demonstrated safety in sensitive mouse and non-human primate neurovirulence models. This vector expressing HIV-1 gag protein has completed evaluation in two Phase I clinical trials. In one trial the rVSV/HIV-1 vector was administered in a ...
TY - JOUR. T1 - Vesicular stomatitis virus glycoprotein contains a dominant cytoplasmic basolateral sorting signal critically dependent upon a tyrosine. AU - Thomas, DNette C.. AU - Brewer, Colleen B.. AU - Roth, Michael G.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - To investigate the contribution of the cytoplasmic domain of the vesicular stomatitis virus G glycoprotein to its basolateral expression in polarized epithelial cells, chimeric proteins containing the external and transmembrane domains of an apically targeted protein, the influenza virus hemagglutinin (HA), and either the G cytoplasmic domain or an unrelated cytoplasmic sequence, were introduced into Madin-Darby canine kidney (MDCK) cells. Addition of the cytoplasmic tail of G to a truncated HA resulted in delivery of greater than 95% of the chimeric protein to the basolateral cell surface, indicating that the G cytoplasmic domain contains a dominant basolateral sorting signal. A similar chimera, containing the cytoplasmic tail of herpes ...
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The cytopathogenicity of vesicular stomatitis virus (VSV) has been attributed mainly to the host shut-off activity of the viral matrix (M) protein, which inhibits both nuclear transcription and nucleocytoplasmic RNA transport, thereby effectively suppressing the synthesis of type I interferon (IFN). The M protein from persistently VSV-infected cells was shown to harbour characteristic amino acid substitutions (M51R, V221F and S226R) implicated in IFN induction. This study demonstrates that infection of human fibroblasts with recombinant VSV containing the M51R substitution resulted in IFN induction, whereas neither the V221F nor the S226R substitution effected an IFN-inducing phenotype. Only when V221F was combined with S226R were the host shut-off activity of the M protein abolished and IFN induced, independently of M51R. The M33A substitution, previously implicated in VSV cytotoxicity, did not affect host shut-off activity. M-mutant VSV containing all four amino acid substitutions retained cytotoxic
DOI: https://doi.org/10.1128/MRA.00499-19 Interpretive Summary: Vesicular stomatitis (VS) is caused by vesicular stomatitis virus (VSV), an infectious agent belonging to the Rhabdoviridae family and the genus vesiculovirus, where vesicular stomatitis Indiana virus (VSIV) and VSNJV are the two main serotypes. The negative sense, single stranded RNA genome of VSV is about 11 kb, and encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L). VS is confined to the Americas, where VSNJV is the serotype responsible for the majority of the clinical cases reported annually in livestock. In Mexico, VSV is endemic in the southern states of Chiapas, Tabasco and Veracruz, where multiple phylogenetic analysis have shown the great genetic diversity associated with the concurrent circulation of multiple lineages. A relevant aspect of these endemic lineages is that some of them may become the precursors of the epidemic lineages responsible ...
Viruses need us. In order to multiply, viruses have to invade a host cell and copy their genetic information. To do so, viruses encode their own replication machinery or components that subvert the host replication machinery to their advantage.. Ebola virus and rabies virus, two of the most lethal pathogens known to humans, belong to an order of RNA viruses that share a common strategy for copying their genomes inside their hosts. Other relatives include Marburg virus, measles, mumps, respiratory syncytial virus and vesicular stomatitis virus (VSV). Scientists study VSV, which causes acute disease in livestock but typically does not lead to illness in people, as a model for viruses that are harmful to humans.. Now a team from Harvard Medical School, using electron cryomicroscopy (imaging frozen specimens to reduce damage from electron radiation), has for the first time revealed the structure of a VSV protein at the atomic level. Called polymerase protein L, it is required for viral replication ...
Viral vectors have been available in various fields such as medical and biological research or gene therapy applications. Targeting vectors pseudotyped with distinct viral envelope proteins that influence cell tropism and transfection efficiency is a useful tool not only for examining entry mechanisms or cell tropisms but also for vaccine vector development. Vesicular stomatitis virus (VSV) is an excellent candidate for development as a pseudotype vector. A recombinant VSV lacking its own envelope (G) gene has been used to produce a pseudotype or recombinant VSV possessing the envelope proteins of heterologous viruses. These viruses possess a reporter gene instead of a VSV G gene in their genome, and therefore it is easy to evaluate their infectivity in the study of viral entry, including identification of viral receptors. Furthermore, advantage can be taken of a property of the pseudotype VSV, which is competence for single-round infection, in handling many different viruses that are either difficult
0025] In certain other embodiments, the VSV vector of the immunogenic composition comprises a G.sub.(ct) mutation and a M.sub.(ncp) mutation. In another embodiment, the G protein encoded by the truncated G gene has a cytoplasmic tail domain consisting of one amino acid (G.sub.(ct-1)) or a cytoplasmic tail domain consisting of nine amino acids (G.sub.(ct-9)). In another embodiment, the M.sub.(ncp) mutation is a mutation of methionine to alanine at position 33 (M33A) and a mutation of methionine to alanine at position 51 (M51A) of the M protein. In one particular embodiment, the immunogenic composition comprises a mutated VSV genome of 3-NPM.sub.(ncp)G.sub.(ct-1)L-5 or 3-NPM.sub.(ncp)G.sub.(ct-9)L-5. In yet other embodiments, the VSV vector of the immunogenic composition further comprises a third class of mutation in its genome, wherein the mutation is a ts mutation, a point mutation, a gene shuffling mutation, a G-stem mutation, an ambisense RNA mutation, a G gene insertion mutation and a ...
Vaccines based on viruses have the ability to provide lifelong protection from disease through induction of robust immunological memory. The Rose laboratory has developed vaccine platforms based on recombinant viruses that can be engineered to express high levels of foreign antigens. One of the major platforms is based on recombinant vesicular stomatitis virus (VSV), a cattle virus that induces potent immune responses in a wide variety of animal species. The virus has been attenuated so that it no longer causes disease and then engineered to express protective antigens from other viruses or bacteria. Immunization with such vectors protects animals from infection and disease caused by numerous pathogens including influenza virus, respiratory syncytial virus, simian immunodeficiency virus (SIV), Ebola virus, and Yersinia pestis, the bacterium that caused the notorious bubonic plagues.. Research projects in the Rose laboratory are focused on further development and testing of the VSV vaccine ...
Nonsegmented negative-strand (NNS) RNA viruses initiate infection by delivering into the host cell an extremely specific RNA synthesis machine comprising the genomic RNA completely encapsidated from the viral nucleocapsid protein and from the viral polymerase. cap-forming actions. The capping enzyme maps to a globular site, which can be juxtaposed towards the band, as well as the cap methyltransferase maps to a far more distal and connected globule flexibly. Upon P binding, L goes through a substantial rearrangement that may reveal an optimal placing of its practical domains for transcription. The structural map of L provides fresh insights in to the interrelationship of its different domains, and their rearrangement on P binding thats likely very important to RNA synthesis. As the set up of conserved areas involved with catalysis can be homologous, the structural insights acquired for VSV L most likely extend to all or any NNS RNA infections. rows in Fig. 4with averages 8C10 in Fig. 1row in ...
WHEREAS, current economic conditions pose new challenges and provide new opportunities to New Jerseys economy; and WHEREAS, New Jersey must meet these challenges and opportunities by supporting the creation of high-quality jobs, particularly in fields related to research and development; and WHEREAS, New Jersey has a world-class industrial base and academic research universities available to support new businesses in technology; and WHEREAS, relationships between industrial and academic research in the State must be strengthened to sustain New Jerseys economy; and WHEREAS, creating a platform for academic and research excellence at New Jerseys public universities in conjunction with the States strong industrial research sector will attract and enhance Federal and private sector funding; and WHEREAS, a comprehensive analysis of the available resources, coupled with the development of a state-wide business plan, will strengthen New Jerseys economy by promoting the resources upon which future ...
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Although viruses are the smallest organisms with the shortest genomes, they have major impacts on human health, causing deadly diseases (e.g., influenza, AIDS, cancer) on a global scale. To reproduce, a virus particle must infect a living cell and divert biosynthetic resources toward production of virus components. A better mechanistic understanding the infection cycle could lead to insights for more effective anti-viral strategies. However, simulating the virus infection cycle is a computationally hard problem because some species fluctuate rapidly while others change gradually in number. We study vesicular stomatitis virus, an experimentally accessible virus for which we have developed a deterministic kinetic model of growth (Lim et al, PLoS Comp Bio, 2006). Stochastic simulation of VSV genome encapsidation is a computationally-intensive chain reaction that produces rapid fluctuations in the nucleocapsid(N) protein that associates with the genome. Analytical results from order statistics ...
Source: Indiana Business Research Center Source: Indiana Business Research Center Source: Indiana Business Research Center Source: Indiana Business Research Center Source: Indiana Business Research Center Source: Indiana Business Research Center
Dairies need to keep a close eye out for vesicular stomatitis, and take action immediately to protect their herds - and Morgan County has quite a few dairies.
Définitions de Indiana House of Representatives, synonymes, antonymes, dérivés de Indiana House of Representatives, dictionnaire analogique de Indiana House of Representatives (anglais)
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Discover hotels in New Jersey, things to do & where to stay. Our hotels are near the very best New Jersey destinations, attractions & outdoor activities.
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New Jersey has a nice variety to its county high points. This list has points in real forested mountains, suburban sprawl, and flat farmland. Passaic and Warren counties are the most serious hikes, with the rest being relatively easy drive-ups or short hikes. Several of these have multiple contours that compete for the high point title, and visting all of them can often be the most time-consuming part of a New Jersey highpointing adventure.. Mike Schwartz of Mendham, NJ has completed this list 13 times as of early 2008.. ...
NEW JERSEY DEFENSE A Publication by the New Jersey Defense Association Volume 29 Issue 3 April 2014 President s Message Michele G. Haas, Esq. Time flies when you re having fun! I realize that my presidency
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Natural Pathways of New Jersey is divided into sections by county, making it very readable and easy for anyone to find the cited areas. The book includes over 100 original watercolor illustrations by artist Valerie Smith-Pope and two simple trips that anyone can take, showcasing the best that New Jersey has to offer ...
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Please Note:. The New Jersey Department of Health and Senior Services has provided notification that beginning in 2006, out-of-state laboratories that do not have a collection station in New Jersey are not required to maintain a Clinical Laboratory License. As a result ARUP is no longer required to maintain a license with this state.. ...
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No state had an average scale score higher than New Jerseys (273), and New Jersey was among the nine states or jurisdictions in the top-performing tier that performed higher than the nations public schools (262) and all other states and jurisdictions ...
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WOONSOCKET, R.I., Nov. 19, 2019 /PRNewswire/ -- CVS Health (CVS) today announced that MinuteClinic, the companys retail medical clinic, has rolled out its video visit offering in the state of New Jersey. People in New Jersey with minor illnesses, minor injuries and skin conditions can now seek
The $2 Trillion aid package passed last week in Washington will do a lot of good. But for the State of New Jersey and for New Jersey municipalities preparing their budget, at a time when all face almost certain revenue losses, more will need to be done. P.... Read on... Home ...
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Mercer İlçesi, Amerika Birleşik Devletlerinin New Jersey eyaletinde yer alan bir ilçedir. İlçenin merkezi Trenton şehridir. İlçenin nüfusu 2010 yılı itibarıyla 366,513 olup New Jersey eyaletinin 12. yoğun nüfuslu ilçelerinden biri olmaktadır. Bu ilçe 1838 yılında kurulmuştur.. ...
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