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Results of Xia-Flex and Verapamil treatments after 3 years - This will likely be my last post but if you sort by my name you will find detailed posts going back several years. I was literally the second person in MA to get Xia-Flex when it was approved in early 2014. The first person beat me by only 1 hour....he had the appointment before me. - Peyronies Society Forums
TY - JOUR. T1 - Verapamil Concentrations in Cerebrospinal Fluid after Oral Administration. AU - Doran, Allen R.. AU - Narang, Prem K.. AU - Meigs, Cynthia Y.. AU - Wolkowitz, Owen M.. AU - Roy, Alec. AU - Breier, Alan. AU - Pickar, David. PY - 1985/5/9. Y1 - 1985/5/9. N2 - To the Editor: Verapamil, a slow calcium-channel blocker widely used in medical practice, has recently been proposed as a treatment for psychiatric disorders, including depression and manic-depressive illness.1 The foundation for this proposal involves the role of intracellular calcium in the functioning of the neurotransmitter system2 3 4 and the ability of calcium antagonists to block these mechanisms in vitro.5 Despite reports of improvements in symptoms of migraine,6 the occurrence of central nervous system-like side effects, such as perceptual disorders7 and mood changes (Rosing D: personal communication), it is unknown to what extent verapamil is accessible to the central nervous system after.. AB - To the Editor: ...
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Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and after verapamil therapy in 40 patients, of whom 16 were also studied during propranolol therapy (80-960 mg/day). All but one patient had normal or supranormal systolic function, but 70% had evidence of diastolic dysfunction, defined as peak LV filling rate (PFR) less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 80 msec. Verapamil did not change LV ejection fraction, peak ejection rate or ejection time, but did increase PFR (control 3.3 +/- 1.0 EDV/sec, verapamil 4.1 +/- 1.1 EDV/sec; p less than 0.001) and reduce time to PFR (control 187 +/- 56 msec, verapamil, 159 +/- 34 msec; p ...
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Medscape - Hypertension, angina, atrial fibrillation-specific dosing for Calan SR, Isoptin SR, (verapamil), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Detailed Verapamil dosage information for adults, the elderly and children. Includes dosages for Hypertension, Angina Pectoris, Arrhythmias and more; plus renal, liver and dialysis adjustments.. Ways to Increase your Personal Mucus when using Clomid. SteadyS YOUR REACTION. mysql_queryAccess denied for dental localhost (using password: NO). 4 Pictures (question resolved) - Outgrown in: prozac, wellbutrin, verapamil dosage available, side verapamil dosage available, weight - Snip: Hey rebchristopher, Taken at the right Ventured at the right dosages, Wellbutrin with Prozac is a generic combination for depression and anxiety. BupropionWellbutrin Niche Loss Other Bloodshot Effects. Verapamil hydrochloride extended-release tablets USP is a calcium ion influx ...
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Based on a retrospective analysis of the DAVIT II database, we attempted to propose subgroups of post-infarction patients with heart failure, who might benefit or not benefit from antiischemic medical intervention. In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placebo in the second week after the infarct and followed up to 18 months. The endpoint was the first major event; that is, death or reinfarction. In patients with heart failure but no ischemia, the event rate was 17.6% in the verapamil-treated patients and 16.5% in the placebo group (hazard verapamil: 1.01; 95% CL: 0.57, 1.79). In patients with both heart failure and residual ischemia, the event rate was 11.3% and 17.8% in the verapamil and placebo groups, respectively (hazard verapamil: 0.60; 95% CL: 0.24, 1.52). Although the latter reduction in major events was not statistically significant, we propose, in accordance with other studies, that in postinfarction patients with both heart ...
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Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Verapamil is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. Verapamil may also be used for purposes not listed in this medication guide.
Verapamil is only found in individuals that have used or taken this drug. Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent. [PubChem]Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamils mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known. [PubChem] Calcium channel antagonists can be quite toxic. In the management of poisoning, early recognition is critical. Calcium channel antagonists are frequently prescribed, and the potential for serious morbidity and mortality with over dosage is significant. Ingestion of these agents should be suspected in any patient who presents in an overdose situation with unexplained hypotension and conduction abnormalities. The potential for toxicity ...
Hi. Been there, done that. Toprol was horrendous for me also, it MADE my chest hurt which I had no previous problems with, caused coughing, fatigue, I actually saw trees that looked like they had a blue haze around them (visual disturbance). My ex-doctor kept pushing this stuff, until I put my foot down. I then went to verapamil which really helped my migraines, blood pressure. I have no problem taking food with it, actually I have a sensitive stomach and food helps buffer the meds, so its a must for me. Verapamil does cause me to flush a bit, feel warm in chest, neck and face which turn red for awhile. Since the migraines are almost gone, thats most important to me. I do feel a bit tranquilized, but manage to get thru the day and get things done. Im on 240 mg., a day, verapamil ER, in CAPSULE form, I feel that the capsule form also helps with stomach issues. Actually its two 120-mg. capsules, because the 240 mg. capsule is so honking huge, it choked me. Frankly, some sources say verapamil ...
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Verapamil, a calcium channel blocker (Fleckenstein, 1977) used for the treatment of cardiac arrhythmias and hypertension (McTavish and Sorkin, 1989), is given as a racemic mixture. Much is known about the stereoselective disposition of the more potent S- versus R-verapamil in human and rats (Bhatti and Foster, 1997; Busse et al., 2006). Binding of verapamil to bovine serum albumin (BSA) revealed that the unbound plasma fraction of R-verapamil (∼0.65) exceeds that of S-verapamil (∼0.55) (Mehvar and Reynolds, 1996). The reverse is true for binding to human serum albumin and α 1-acid glycoprotein (Mehvar and Reynolds, 1996; Hanada et al., 1998), whereas the plasma bound fraction of verapamil in human is concentration independent within the therapeutic range and unaltered by the presence of norverapamil (Keefe et al., 1981). The distribution of verapamil and norverapamil into red blood cells (RBCs) is also stereoselective [human (S , R) versus rat (R , S)] (Robinson and Mehvar, 1996).. Much ...
TY - JOUR. T1 - Verapamil in a new model of severe local myocardial ischaemia due to combined coronary occlusion and stenosis. AU - Végh, A.. AU - Szekeres, L.. AU - Udvary, Éva. PY - 1987/11/24. Y1 - 1987/11/24. N2 - The effect of verapamil was studied in a new canine model of local myocardial ischaemia. In this model in addition to the critical constriction of the left circumflex coronary artery, the left anterior descending branch was suddenly occluded. Experiments were performed in the anaesthetized, thoracotomized and artificially respired dog. The model represents a severe form of myocardial ischaemia and mimics the clinical situation in which usually more than one coronary artery is involved in the stenotic process. Verapamil (0.15 mg kg -1 i.v.) moderated the extent of the ischaemic changes (indicated by the ST segment elevation in the epicardial and endocardial ECG) as well as their consequences e.g. the incidence and severity of early postocclusion and reperfusion arrhythmias. This ...
Verapamil is class IV anti arrhythmic agent.Verapamil will has a negative inotropic action. Verapamil is useful in treating patient with supraventricular tachycardia , controlling rates in atrial fibrillation, angina pectoris and hypertension.
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Verapamil 180 mg pills, (brand names: Isoptin, Verelan, Calan, Bosoptin), is an L-type calcium channel blocker used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, headaches. Not to be used along with beta-blockers. Class 4 antiarrhythmic, more effective than digoxin in controlling ventricular rate. Approved by FDA in 1981. One of its purified isomers does not cause constipation whereas racemic Verapamil does. Used as a vasodilator during cryopreservation of blood vessels. - Stock Image C003/0154
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... Verapamil is used to treat chest pain, high blood pressure, and certain irregular heart rhythms by relaxing the blood vessels, which allows blood to flow easier through them.
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After coronary occlusion, myocardium originally supplied by the occluded vessel ultimately separates into infarct and surviving muscle. To clarify this process, evolution of collateral blood flow to infarct and to surviving myocardium was retrospectively analyzed after permanent left anterior descending occlusion in 24 closed chest dogs. Microspheres were injected before occlusion and 5 and 20 minutes and 4 hours after occlusion. Ten minutes after occlusion, dogs received either verapamil, 0.4 mg/kg, followed by 0.6 mg/kg per hour for 6 hours (n = 10) or equivalent saline solution (n = 14). These dogs were sacrificed 3 days later, the distribution of the occluded artery was defined by dye perfusion and infarcted myocardium was determined by triphenyltetrazolium staining of heart slices. Surviving muscle within the distribution of the occluded artery was divided into medial regions adjacent to the infarct (medial adjacent) and remote from the infarct (medial remote) and lateral regions adjacent ...
Alcoholic depression of left ventricular function was produced in normal hamsters by the administration of increasing concentrations of alcohol in drinking water (up to 50%) for 6 months. The result was assessed by phosphorus-31 nuclear magnetic resonance of isolated perfused hearts and high-pressure liquid chromatography of freeze-clamped tissues. Hemodynamic data and myocardial oxygen consumption were also monitored. Alcoholic hamsters had significantly higher inorganic phosphate and lower ATP levels, while maintaining normal intracellular pH, phosphocreatine, and creatine. Although coronary flow and oxygen consumption were maintained at normal levels, hamsters ingesting 50% ethanol had significantly lower left ventricular developed pressure and dP/dt. Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional abnormalities. It is hypothesized that alcohol produces membrane abnormalities leading to adverse ion flux, and that these ...
The investigators have demonstrated previously that the calcium channel antagonists (CCAs) verapamil, nifedipine, and diltiazem can block in vitro and in vivo meningioma growth at clinically relevant doses (Jensen, Lee et al. 1995; Jensen, Petr et al. 2000; Jensen and Wurster 2001). However, only modest growth inhibition was exhibited in the tumors in these studies with CCAs alone. Many authors have shown augmented growth inhibition by adding CCAs to traditional chemotherapies in other tumor types (Tsuruo, Iida et al. 1981; Tsuruo, Iida et al. 1983; Helson 1984; Robinson, Clutterbuck et al. 1985; Ince, Appleton et al. 1986; Merry, Fetherston et al. 1986; Cano-Gauci and Riordan 1987). For instance, the combination of verapamil and 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) is better than BCNU alone in inhibiting the growth of human gliomas in vitro and in vivo (Bowles, Pantazis et al. 1990). Calcium antagonists seem to exert the majority of their anti-tumor effects by inhibiting calcium ...
Verapamil is a potent calcium antagonist known to inhibit excitation-contraction coupling in both myocardium and myometrium. Its effect upon glucose- and sulfonylurea-induced insulin release was investigated in the isolated perfused rat pancreas.. After twenty-five minutes pretreatment and at concentrations ranging between 0.8 and 8.1 μM, verapamil caused a dose-related inhibition of glucose-induced insulin release during both the early and late phase of the secretory process. At a concentration of 0.8 μM, the degree of inhibition was more marked when the exposure time to verapamil prior to stimulation with glucose was increased to sixty minutes. Verapamil also inhibited gliclazide-induced insulin release. Infusion of verapamil during the late phase of the secretory response to glucose demonstrated that the inhibition of insulin release was an immediate and reversible phenomenon. The inhibitory effect of verapamil was enhanced at a subnormal calcium concentration and reduced at a high calcium ...
Verapamil HCl is a calcium channel blocker administered on thrice a day dosage regimen. In the present study resinates of verapamil HCl were formulate..
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Riva-Verapamil SR: Verapamil belongs to the class of medications called calcium channel blockers. The sustained release (SR) form of this medication is used for the treatment of mild-to-moderate high blood pressure, when beta-blockers or diuretics (water pills) are not recommended or have caused unacceptable side effects. The immediate-release form of verapamil may be used to treat certain abnormal heart rhythms, angina (chest pain) and certain conditions where the heart muscle is enlarged, as well as blood pressure. It works to control blood pressure and reduce the number of angina attacks by relaxing blood vessels. It also helps to normalize heart rhythms.
Riva-Verapamil SR: Verapamil belongs to the class of medications called calcium channel blockers. The sustained release (SR) form of this medication is used for the treatment of mild-to-moderate high blood pressure, when beta-blockers or diuretics (water pills) are not recommended or have caused unacceptable side effects. The immediate-release form of verapamil may be used to treat certain abnormal heart rhythms, angina (chest pain) and certain conditions where the heart muscle is enlarged, as well as blood pressure. It works to control blood pressure and reduce the number of angina attacks by relaxing blood vessels. It also helps to normalize heart rhythms.
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Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses may need some adjustment, make sure to have your condition monitored regularly.. ...
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