EM-CONSULTE.COM se declara a la CNIL, la declaración N º 1286925.. En virtud de la Ley N º 78-17 del 6 de enero de 1978, relativa a las computadoras, archivos y libertades, usted tiene el derecho de oposición (art.26 de la ley), el acceso (art.34 a 38 Ley), y correcta (artículo 36 de la ley) los datos que le conciernen. Por lo tanto, usted puede pedir que se corrija, complementado, clarificado, actualizado o suprimido información sobre usted que son inexactos, incompletos, engañosos, obsoletos o cuya recogida o de conservación o uso está prohibido ...

The authors investigated the roles of endothelin (ET)-1 and the ETA receptor in the pathogenesis of delayed cerebral vasospasm following subarachnoid hemorrhage (SAH). A study was made of the preventive effect of a novel ETA receptor antagonist, BQ-123, on vasospasm and the expression of the ETA receptor messenger ribonucleic acid (mRNA) using a canine two-hemorrhage SAH model. Continuous intrathecal administration of BQ-123 (5 x 10(-6) mol/day) prevented narrowing of the basilar artery on Day 7 after SAH in 97.6% of cases in the study group versus 70.7% of cases in the control group (p | 0.05). While expression of the mRNA-coding ETA receptor was not detected in the control animals, it markedly increased on Day 3 after SAH and was also detected on Day 7. The results suggest that endothelin-1 and the ETA receptor participate in the pathogenesis of delayed cerebral vasospasm following SAH.

TY - JOUR. T1 - Balloon angioplasty immediately after surgical clipping for symptomatik vasospasm on admission. Report of four cases. AU - Fujii, Yasunobu. AU - Takahashi, Akira. AU - Ezura, Masayuki. AU - Mizoi, Kazuo. PY - 1995/6/1. Y1 - 1995/6/1. N2 - In spite of recent advancements in the management of ruptured aneurysm, there are still controversies as to how to threat the patients in serious conditions, one of these concerning whether to operate patients admitted with symptomatic vasospasm (vasospasm on admission) and when. While early surgery may protect patient from further rupturing, it may also increase risk of worsening by inducing much more vasospasm. Four cases of severe vasospasm associated with aneurysmal subarachnoid hemorrhage (SAH) were reported. All of these cases showed symptomatic and angiographical vasospasm on their admission 3-11 days after initial attack of SAH. All cases had a preoperative clinical grading using Hunt & Kosnik of IV, and were treated by early surgery ...

TY - JOUR. T1 - Endovascular options in the treatment of delayed ischemic neurological deficits due to cerebral vasospasm.. AU - Eddleman, Christopher S.. AU - Hurley, Michael C.. AU - Naidech, Andrew M.. AU - Batjer, H. Hunt. AU - Bendok, Bernard R.. PY - 2009. Y1 - 2009. N2 - The second leading cause of death and disability in patients with aneurysmal subarachnoid hemorrhage (SAH) is delayed cerebral ischemia due to vasospasm. Although up to 70% of patients have been shown to have angiographic evidence of vasospasm, only 20-30% will present with clinical changes, including mental status changes and neurological deficits that necessitate acute management. Endovascular capabilities have progressed to become viable options in the treatment of cerebral vasospasm. The rationale for intraarterial therapy includes the fact that morbidity and mortality rates have not changed in recent years despite optimized noninvasive medical care. In this report, the authors discuss the most common endovascular ...

Although cerebral vasospasm in SAH patients is a major cause of morbidity and mortality, the precise mechanisms for the delayed cerebral vasospasm remain unclear. Cerebral vasospasm after SAH was attenuated not only by local administration of superoxide dismutase18,19⇓⇓ but also by overexpression of Cu/Zn-superoxide dismutase in the transgenic mice,20 suggesting the pivotal role of oxygen radicals in the development of cerebral vasospasm. In the present experiment, we demonstrated that the time course of the development of vasospasm in the rat 2-hemorrhage model was similar to that of vasospasm after a SAH in the clinical situation. Minimal narrowing was present by 1 to 2 days and had progressively increased by 5 days after the second injection of autologous blood into cisterna magna. The delayed cerebral vasospasm in SAH rats was significantly attenuated by pretreatment with DPI, an NAD(P)H oxidase inhibitor. Considering other reports with our results, NAD(P)H-derived superoxide might be ...

TY - JOUR. T1 - Endovascular treatment strategies for cerebral vasospasm.. AU - Mindea, Stefan A.. AU - Yang, Benson P.. AU - Bendok, Bernard R.. AU - Miller, Jeffrey W.. AU - Batjer, H. Hunt. PY - 2006. Y1 - 2006. N2 - Cerebral vasospasm is a significant cause of morbidity and mortality in patients who have sustained a subarachnoid hemorrhage from aneurysm rupture. Symptomatic cerebral vasospasm is also a strong predictor of poor clinical outcome and has thus drawn a great deal of interest from cerebrovascular surgeons. Although medical management is the cornerstone of treatment for this condition, endovascular intervention may be warranted for those in whom this treatment fails and in whom symptomatic vasospasm subsequently develops. The rapid advancements in endovascular techniques and pharmacological agents used to combat this pathological state continue to offer promise in broadening the available treatment armamentarium. In this article the authors discuss the rationale and basis for using ...

INTRODUCTION: Cerebral vasospasm is the leading cause of morbidity and mortality in patients with aneurysmal subarachnoid haemorrhage (SAH) surviving the initial ictus. Commonly used techniques for vasospasm assessment are digital subtraction angiography and transcranial Doppler sonography. These techniques can reliably identify only the major vessel spasm and fail to estimate its haemodynamic significance. To overcome these issues and to enable comprehensive non-invasive assessment of vasospasm inside the interventional suite, a novel protocol involving measurement of parenchymal blood volume (PBV) using C-arm flat detector computed tomography (FDCT) was implemented. MATERIALS AND METHODS: Patients from the neuro-intensive treatment unit (ITU) with suspected vasospasm following aneurysmal SAH were scanned with a biplane C-arm angiography system using an intravenous contrast injection protocol. The PBV maps were generated using prototype software. Contemporaneous clinically indicated MR scan including

Diffuse cerebral vasospasm is a rare complication following tumour resection. This phenomenon seems to be even rarer in the paediatric population and more so following resections of posterior fossa tumours. Here we report diffuse cerebral vasospasm in a child with hypoglossal nerve Schwannoma eight days following resection of the tumour.

The occurrence of vasospasm can be reduced by preventing the occurrence of atherosclerosis. This can be done in several ways, the most important being lifestyle modifications-decreasing low-density lipoprotein (LDL), quitting smoking, physical activity, and control for other risk factors including diabetes, obesity, and hypertension. Pharmacological therapies include hypolipidemic agents, thrombolytics and anticoagulants. Pharmacological options for reducing the severity and occurrence of ischemic episodes include the organic nitrates classified as having long acting (i.e. isosorbide dinitrate) and short acting (i.e. nitroglycerin) durations of action. These drugs work by increasing nitric oxide levels in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary resistance, allowing for increased oxygen supply to the vital organs (myocardium). The nitric oxide increase in the blood resulting from these drugs also causes dilation of ...

Despite considerable improvement in its understanding and management, cerebral vasospasm after aneurysmal SAH remains a source of etiopathogenic controversies and is still responsible for 10% to 20% of death and disability.10 11 12 One of the most debated controversies is the contribution of arterial narrowing, as demonstrated by TCD or angiographic studies, to delayed neurological morbidity.3 This may be even more challenging in head injury, where neurological outcome is influenced by multiple factors.5 6 In this ongoing debate, most authors have stressed that arterial narrowing, as evidenced by TCD or angiographic studies, is significantly more common than the incidence of delayed brain ischemia and should therefore be distinguished from hemodynamically significant vasospasm.6 13 Moreover, the incidence of brain infarction in those patients suffering from symptomatic vasospasm is even lower, ranging from 3% to 17% in different CT studies of SAH patients.14 15 16 A generally accepted assumption ...

A Randomized Clinical Trial with security and dose testing of Sildenafil Citrate in patients with subarachnoid hemorrhage due to a rupture of a cerebral aneurism for prevention of cerebral vasospasm. The cerebral vasospasm is a decrease in blood flow that occurs when the intracranial vessels lose their capability of self-control of dilations and contractions. Patients with subarachnoid hemorrhage without neurological deficits who underwent endovascular or surgical correction of the aneurysm can participate in this trial. They will be randomized to a daily doses of 75 mg of Sildenafil, 150 mg of Sildenafil or Placebo from the third to the 14th day post bleeding. Today there is no proven clinical treatment for prevention of cerebral vasospasm ...

Objective : Removal of blood from subarachnoid space with a lumbar drainage (LD) may decrease development of cerebral vasospasm. We evaluated the effectiveness of a LD for a clinical vasospasm and outcomes after clipping of aneurysmal subarachnoid hemorrhage (SAH). Methods : Between July 2008 and July 2013, 234 patients were included in this study. The LD group consisted of 126 patients, 108 patients in the non LD group. We investigated outcomes as follow : 1) clinical vasospasm, 2) angioplasty, 3) cerebral infarction, 4) Glasgow outcome scale (GOS) score at discharge, 5) GOS score at 6-month follow-up, and 6) mortality. Results : Clinical vasospasm occurred in 19% of the LD group and 42% of the non LD group (p,0.001):Angioplasty was performed in 17% of the LD group and 38% of the non LD group (p=0.001). Cerebral infarctions were detected in 29% and 54% of each group respectively (p,0.001). The proportion of GOS score 5 at 6 month follow-up in the LD group was 69%, and it was 58% in the non LD ...

Stroke Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all aspects of stroke.

We retrospectively analyzed the charts of 537 patients with SAH, admitted in our institution between January 1987-December 1997. Of those, 156 (29%) received HT therapy, for clinically neurologic deficits attributable to cerebral vasospasm, after surgical aneurysm repair. Symptomatic vasospasm was defined as decrease in the level of consciousness or the appearance of new focal neurologic signs. Clinical and angiographic improvement, after HT alone, or in combination with neuroradiological intervention was studied. ...

Object. The goal of this study was to evaluate regional cerebral blood flow (rCBF) monitoring, performed using thermal-diffusion (TD) flowmetry, as a novel means for the bedside diagnosis of symptomatic vasospasm.. Methods. Fourteen patients with high-grade subarachnoid hemorrhage (SAH) who underwent early clip placement for anterior circulation aneurysms were prospectively entered into the study. Thermal-diffusion microprobes were implanted into the white matter of vascular territories that were deemed at risk for developing symptomatic vasospasm. Data on arterial blood pressure, intracranial pressure, cerebral perfusion pressure, rCBF measurement obtained using a TD probe (TD-rCBF), cerebrovascular resistance (CVR), and blood flow velocities were collected at the patients bedside. The diagnosis of symptomatic vasospasm was based on the manifestation of a delayed ischemic neurological deficit and/or a reduced territorial level of CBF as assessed using stable Xe-enhanced computerized tomography ...

Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim was to evaluate the effect of pharmacologic treatments that have been tested in humans and in preclinical studies to determine if animal models inform results reported in humans. A systematic review and meta-analysis of SAH studies was performed. We investigated predictors of translation from animals to humans with multivariate logistic regression. Pharmacologic reduction of vasospasm was effective in mice, rats, rabbits, dogs, nonhuman primates (standard mean difference of 1.74; 95% confidence interval 2.04 to 1.44) and humans. Animal studies were generally of poor methodologic quality and there was evidence of publication bias. Subgroup analysis by drug and species showed that statins, tissue plasminogen activator, erythropoietin, endothelin receptor antagonists, calcium channel antagonists, fasudil, and tirilazad were effective whereas magnesium

TY - JOUR. T1 - Vasospasm secondary to ruptured aneurysm. T2 - assessment by digital intravenous angiography.. AU - Pinto, R. S.. AU - Kricheff, I. I.. AU - De Filipp, G.. AU - Flamm, E. S.. AU - Lin, J. P.. PY - 1983/5/1. Y1 - 1983/5/1. N2 - Digital intravenous angiography was used for the documentation and evaluation of cerebral vasospasm secondary to acute ruptured aneurysm. Attenuation of vessel caliber and/or generalized poor visualization of intracranial arteries and prolongation of circulation time were observed in seven patients with the acute clinical diagnosis of cerebral vasospasm. Posttreatment intravenous angiography demonstrated improvement in both arterial caliber and circulation time in six patients who responded to medical therapy for vasospasm. Digital intravenous angiography allowed repeat investigations of the intracranial vasculature safely and quickly without undue risk to the critically ill patient.. AB - Digital intravenous angiography was used for the documentation and ...

7Bak rkoy Research and Training Hospital, Psychiatry Clinic, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.17206-16.2 AIM: Cerebral vasospasm after subarachnoid hemorrhage (SAH) may lead to a devastating neurological outcome by inducing cerebral ischemia. However the role of external carotid artery (ECA) vasospasm has been rarely reported in the literature. The aim of this study was to elucidate the effect of ECA vasospasm on cerebral ischemia related neurodegeneration in the cerebral cortex after SAH.. MATERIAL and METHODS: This study was performed on 23 rabbits, divided into three groups: control (n=5), sham (n=5), and SAH (n=13). Experimental SAH was performed by injecting 0.75 mL auricular arterial homologous blood into the cisterna magna. After three weeks, the animals were decapitated and the common carotid arteries with their external and internal branches and the brains were examined histopathologically. Vasospasm indexes (VSI) of ECAs and internal carotid arteries (ICAs) and degenerated ...

Vasospasm following cerebral aneurysm rupture is one of the most devastating sequelae and the most common cause of delayed ischemic neurological deficit (DIND). Because vasospasm also is the most common cause of morbidity and mortality in patients who survive the initial bleeding episode, it is imperative not only to diagnose the condition but also to predict which patients are likely to become symptomatic. The exact pathophysiology of vasospasm is complex and incompletely elucidated. Early recognition of vasospasm is essential because the timely use of several therapeutic interventions can counteract this disease and prevent the occurrence of DIND. However, the prompt implementation of these therapies depends on the ability to predict impending vasospasm or to diagnose it at its early stages.. A number of techniques have been developed during the past several decades to evaluate cerebral perfusion, including positron emission tomography, xenon-enhanced computed tomography, single-photon ...

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...

Cerebral vasospasm is the prolonged, intense vasoconstriction of the larger conducting arteries in the subarachnoid space which is initially surrounded by a clot. Significant narrowing develops gradually over the first few days after the aneurysmal rupture. ...

Global Cerebral Vasospasm Market Research Report, by Treatment (triple-H therapy, nimodipine and other), by Route of Administration (oral, intravenous and

DCI is a complex state described as clinical deterioration that may lead to cerebral infarction and permanent neurologic impairment. The diagnosis of DCI in aneurysmal SAH remains challenging due to the difficulty of adequately assessing critically ill and comatose patients. Therefore, imaging has been used as additional evidence to support a diagnosis of DCI, particularly in the management and treatment decision-making. Arterial narrowing on imaging studies, such as transcranial Doppler sonography, CTA, and DSA, has been used to detect vasospasm as proof of concept for the diagnosis of DCI. Current recommendations advise that vasospasm should be evaluated in conjunction with evidence of clinical deterioration.1 It is important to recognize that though severe vasospasm may decrease cerebral perfusion, it may not result in DCI.. In recent years, CTP has been added as complementary imaging to CTA and DSA to evaluate hemodynamic disturbances thought to occur in DCI. Perfusion deficits are described ...

Stroke is a frequently reported, though uncommon, complication of drug abuse, primarily cocaine. The pathogenesis is uncertain, although such cerebrovascular events may result from sympathetically mediated vasoconstriction of cerebral vessels. Amphetamine, another sympathomimetic amine that is commonly abused, may also cause strokes by producing cerebral vasospasm and/or vasculitis. Amphetamine and its derivatives are frequent adulterants of illegally obtained cocaine and may also be used concurrently; the effect(s) of this combination of drugs upon the cerebral vasculature is not known. Our aim was to develop an animal model that would enable us to study the ability of these drugs to produce acute cerebral vasospasm and to observe the response to IV administration of amphetamine and cocaine, either alone or together. Magnified basilar artery arteriograms were obtained in 12 New Zealand white rabbits before and after IV administration of cocaine, methamphetamine, or both, at various dosages. Low ...

Hello ladies, I found this forum a week ago when I was desperate for some answers. Since then I have been reading here for encouragement and advice and thought it was time to post myself since I feel like I am hitting a wall. My son will be 5 weeks on Sunday. Breastfeeding has been quite the challenge for us. He had a poor latch in the beginning which resulted in me getting very cracked, bleeding nipples. We went to the lactation consultants and got it worked out. I thought we were

I posted my experience in this forum below with being diagnosed with vasospasm. Ive now got questions related to my apparent allergic reaction to Norvasc. Its been 3 weeks since my vasospasm even...

DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.

This study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH). Twenty rabbits were assigned randomly to one of four groups. Animals in Group I were not subjected to SAH or sham operation (control group, n = 5). Animals in Group II were subjected to sham operation and received no treatment after the procedure (sham group, n = 5). Animals in Group III were subjected to SAH and received no treatment after SAH induction (SAH group, n = 5). Animals in Group IV were subjected to SAH and received five sessions of HBOT at 2.4 atmospheres absolute (ATA) for 2 h (treatment group, n = 5). Animals were euthanized by perfusion and fixation 72 h after procedures. Basilar artery vasospasm indices, arterial wall thicknesses, and cross-sectional luminal areas were evaluated. Statistical comparisons were performed using Kruskal-Wallis and Mann-Whitney U tests. Mean basilar artery ...

TY - JOUR. T1 - Preconditioning effect on cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. AU - Kim, Young Woo. AU - Zipfel, Gregory J.. AU - Ogilvy, Christopher S.. AU - Pricola, Katie L.. AU - Welch, Babu G.. AU - Shakir, Nabeel. AU - Patel, Bhuvic. AU - Reavey-Cantwell, John F.. AU - Kelman, Craig R.. AU - Albuquerque, Felipe C.. AU - Kalani, M. Yashar S. AU - Hoh, Brian L.. PY - 2014. Y1 - 2014. N2 - Background: Recent experimental evidence indicates that endogenous mechanisms against cerebral vasospasm can be induced via preconditioning. Objective: To determine whether these vascular protective mechanisms are also present in vivo in humans with aneurysmal subarachnoid hemorrhage. Methods: A multicenter retrospective cohort of patients with aneurysmal subarachnoid hemorrhage was examined for ischemic preconditioning stimulus: preexisting steno-occlusive cerebrovascular disease (CVD) and/or previous cerebral infarct. Generalized estimating equation models were performed ...

DelveInsight launched a new report on Aneurysmal Subarachnoid Hemorrhage Pipeline Insight, 2020. Aneurysmal Subarachnoid Hemorrhage Pipeline Insight, 2020 report by DelveInsight outlays comprehensive insights of present clinical development scenario and growth prospects across the Aneurysmal Subarachnoid Hemorrhage market. A detailed picture of the Aneurysmal Subarachnoid Hemorrhage pipeline landscape is provided, which includes the disease overview and Aneurysmal Subarachnoid Hemorrhage treatment guidelines. The assessment part of the report embraces in-depth Aneurysmal Subarachnoid Hemorrhage commercial assessment and clinical assessment of the Aneurysmal Subarachnoid Hemorrhage pipeline products from the pre-clinical developmental phase to the marketed phase. In the report, a detailed description of the drug is proffered including mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Aneurysmal Subarachnoid ...

DelveInsight launched a new report on Aneurysmal Subarachnoid Hemorrhage Pipeline Insight, 2020. Aneurysmal Subarachnoid Hemorrhage Pipeline Insight, 2020 report by DelveInsight outlays comprehensive insights of present clinical development scenario and growth prospects across the Aneurysmal Subarachnoid Hemorrhage market. A detailed picture of the Aneurysmal Subarachnoid Hemorrhage pipeline landscape is provided, which includes the disease overview and Aneurysmal Subarachnoid Hemorrhage treatment guidelines. The assessment part of the report embraces in-depth Aneurysmal Subarachnoid Hemorrhage commercial assessment and clinical assessment of the Aneurysmal Subarachnoid Hemorrhage pipeline products from the pre-clinical developmental phase to the marketed phase. In the report, a detailed description of the drug is proffered including mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Aneurysmal Subarachnoid ...

TY - JOUR. T1 - Early mobilisation of patients in the acute hospital setting following aneurysmal subarachnoid haemorrhage - A survey of current physiotherapy practice. AU - Hernandez, Sabrina. AU - Thomas, Peter J.. AU - Udy, Andrew. AU - Hodgson, Carol. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Aneurysmal subarachnoid haemorrhage is a catastrophic form of stroke. There is very limited literature to guide physiotherapists on the type and timing of mobility interventions that should be provided during the acute phase. The aim of this study was to determine the current practices of physiotherapists in early mobilisation of patients with aneurysmal subarachnoid haemorrhage. A purpose-designed electronic survey was distributed to 71 physiotherapists in hospitals that specialise in the management of aneurysmal subarachnoid haemorrhage throughout Australia and New Zealand. A response rate of 80% was obtained (n=57). Prior to the aneurysm being repaired, the most common practice reported by ...

TY - JOUR. T1 - APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage. AU - Gallek, Matthew J. AU - Conley, Yvette P.. AU - Sherwood, Paula R.. AU - Horowitz, Michael B.. AU - Kassam, Amin. AU - Alexander, Sheila A.. PY - 2009/1. Y1 - 2009/1. N2 - Apolipoprotein E (apoE), the major apolipoprotein in the central nervous system, has been shown to influence neurologic disease progression and response to neurologic injury in a gene-specific manner. Presence of the APOE4 allele is associated with poorer response to traumatic brain injury and ischemic stroke, but the association between APOE genotype and outcome following aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of this project was to investigate the association between APOE genotype and outcome after SAH. We also explored the association of APOE4 genotype and cerebral vasospasm (CV) presence in a subsample of our population with available angiographic data. A sample of 206 aneurysmal SAH ...

Reversible cerebral vasoconstriction syndrome (RCVS, sometimes called Call-Fleming syndrome) is a disease characterized by a weeks-long course of thunderclap headaches, sometimes focal neurologic signs, and occasionally seizures. Symptoms are thought to arise from transient abnormalities in the blood vessels of the brain. In some cases, it may be associated with childbirth, vasoactive or illicit drug use, or complications of pregnancy. For the vast majority of patients, all symptoms disappear on their own within three weeks. Deficits persist in a small minority of patients, with severe complications or death being very rare. Because symptoms resemble a variety of life-threatening conditions, differential diagnosis is necessary. The key symptom of RCVS is recurrent thunderclap headaches, which over 95% of patients experience. In two-thirds of cases, it is the only symptom. These headaches are typically bilateral, very severe and peak in intensity within a minute. They may last from minutes to ...

BACKGROUND AND AIM OF THE STUDY: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe thunderclap headache, with or without associated neurological symptoms and neuroimaging findings of reversible vasoconstriction of cerebral arteries. Puerperium is a recognized precipitant, but the incidence of puerperal RCVS is unknown. We conducted a prospective study to assess incidence, risk factors and clinical features of RCVS. MATERIAL AND METHOD: Nine-hundred consecutive puerperae were prospectively enrolled within three days of delivery. Past medical history, basal demographic, anthropometric and biological variables were recorded. Transcranial Colour Coded Sonography (TCCS) was performed to assess early signs of vasospasm in brain vessels. A structured telephone interview was planned in all subjects one month postdelivery. RESULTS: Thunderclap headache was recorded in 8 subjects (0.9%) on the first visit. At the one month follow-up interview 27 more patients reported having had at

Aneurysmal Subarachnoid Hemorrhage Market research study provides an extensive information of important participants, such as suppliers, manufacturers, distributors, traders, consumers, investors, etc. Aneurysmal Subarachnoid Hemorrhage Market study depicts an in-depth analysis on the current status of Aneurysmal Subarachnoid Hemorrhage market that consists of important types, and end uses. The data type of the Aneurysmal Subarachnoid Hemorrhage market study contains market revenue, import, export, progress rate, consumption, etc. Further, the study focuses on the prominent and emerging regional and global trends contributing to the growth of the global Aneurysmal Subarachnoid Hemorrhage Market over the stipulated timeframe.. The Aneurysmal Subarachnoid Hemorrhage Market research study also covers distribution channel, industry chain, manufacturing techniques, and cost framework. In addition, market regulatory structure, technological developments in concerned sectors, and tactical avenues are ...

Reversible cerebral vasoconstriction syndrome (RCVS) is a group of conditions with a common clinical and radiologic presentation. It is characterized by thunderclap headache and reversible vasoconstriction of the cerebral arteries. Terminology ...

Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vas …

While a wide array of pathological changes occur in cerebral arteries following subarachnoid hemorrhage (SAH), the most consistent is endothelial damage. Since the endothelium normally modulates reflexes that influence vascular tone, any damage to it may represent a significant contributor to cerebral vasospasm following SAH. This experimental study investigates the correlation between ...

Global Aneurysmal Subarachnoid Hemorrhage Market : Snapshot. According to the National Institutes of Health (NIH), aneurysmal subarachnoid hemorrhage (SAH) has turned into a glaring health burden across the world and possesses high rates of permanent disabilities and fatalities. It has been estimated by the NIH that approximately 9 out of 100,000 people across the world suffer from some variation of aneurysmal subarachnoid hemorrhage, a number which is more concerning in the U.S. wherein 30,000 people are diagnosed for SAH each year. Among these cases, raptured cerebral aneurysms accounts for nearly 80% of the non-traumatic aneurysmal subarachnoid hemorrhage. Going forward, these numbers are expected to mount even further, and thereby prove to be boon for the players in the global market for aneurysmal subarachnoid hemorrhage.. Get Sample Copy of the Report @ https://www.tmrresearch.com/sample/sample?flag=B&rep_id=31. Smoking, hypertension, history of intracranial aneurysms in immediate ...

TY - JOUR. T1 - Diagnosis of cerebral vasospasm and risk of delayed cerebral ischemia related to aneurysmal subarachnoid haemorrhage. T2 - an overview of available tools. AU - Bacigaluppi, Susanna. AU - Zona, Gianluigi. AU - Secci, Francesca. AU - Spena, Gianantonio. AU - Mavilio, Nicola. AU - Brusa, Giulia. AU - Agid, Ronit. AU - Krings, Timo. AU - Ottonello, Gianandrea. AU - Fontanella, Marco. PY - 2015/3/4. Y1 - 2015/3/4. N2 - In the first weeks following aneurysmal subarachnoid haemorrhage, cerebrovascular alterations may impact the outcome significantly. Diagnosis of cerebral vasospasm and detection of alterations at risk of delayed cerebral ischemia are key targets to be monitored in the post-acute phase. Available tools include clinical monitoring, as well as studies that can detect possible arterial narrowing, alterations of perfusion, metabolism and neurophysiology. Each technique is able to investigate possible vascular impairment and has different advantages and limits. All available ...

BACKGROUND: The pathophysiology of ischemic cerebral lesions following aneurysmal subarachnoid hemorrhage (SAH) is poorly understood. There is growing evidence that inflammatory reactions could be involved in the pathogenesis of such delayed occurring ischemic lesions. The aim of this study was to evaluate adhesion molecules with regard to these lesions following SAH. METHODS: Serum and cerebrospinal fluid (CSF) samples were taken daily from 15 patients up to day 9 after SAH and evaluated for intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1). RESULTS: CSF and serum samples correlated well during nearly the whole time course (p , 0.0001). A secondary increase in ICAM-1 and VCAM-1 in the serum and CSF correlated with an increase in flow velocity in the transcranial Doppler (p , 0.0001 and p , 0.007) but not to a delayed lesion in the CT scan. CONCLUSION: We believe that inflammatory processes are involved in the pathogenesis of cerebral vasospasm but they might ...

Details of the image Reversible cerebral vasoconstriction syndrome (RCVS) with associated convexity subarachnoid haemorrhage, nimodipine-reversibility Modality: DSA (angiography) (External carotid artery)

TY - JOUR. T1 - The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage. AU - Lim, Michael. AU - Bower, Regina S.. AU - Wang, Ying. AU - Sims, Leroy. AU - Bower, Mark R.. AU - Joaquin, Camara Quintana. AU - Li, Gordon. AU - Cheshier, Samuel. AU - Harsh, Griffith R.. AU - Steinberg, Gary K.. AU - Guccione, Samira. PY - 2012/7. Y1 - 2012/7. N2 - Vasospasm is a major contributor to morbidity and mortality in aneurysmal subarachnoid hemorrhage (SAH), with inflammation playing a key role in its pathophysiology. Myeloperoxidase (MPO), an inflammatory marker, was examined as a potential marker of vasospasm in patients with SAH. Daily serum samples from patients with aneurysmal SAH were assayed for MPO, and transcranial Doppler (TCDs) and neurological exams were assessed to determine vasospasm. Suspected vasospasm was confirmed by angiography. Peak MPO levels were then compared with timing of onset of vasospasm, based on clinical exams, TCDs and ...

The Aneurysmal Subarachnoid Hemorrhage (ASH) pipeline report provides detailed information of the Aneurysmal Subarachnoid Hemorrhage (ASH) pipeline products from the initial phase of product development until its commercialisation in the Aneurysmal Subarachnoid Hemorrhage (ASH) market.

Background In patients with aneurysmal subarachnoid hemorrhage, elevation of the head of the bed during vasospasm has been limited in an attempt to minimize vasospasm or its sequelae or both. Consequently, some patients have remained on bed rest for weeks.. • Objectives To determine how elevations of the head of the bed of 20° and 45° affect cerebrovascular dynamics in adult patients with mild or moderate vasospasm after aneurysmal subarachnoid hemorrhage and to describe the response of mild or moderate vasospasm to head-of-bed elevations of 20° and 45° with respect to variables such as grade of subarachnoid hemorrhage and degree of vasospasm.. • Methods A within-patient repeated-measures design was used. The head of the bed was positioned in the sequence of 0°-20°-45°-0° in 20 patients with mild or moderate vasospasm between days 3 and 14 after aneurysmal subarachnoid hemorrhage. Continuous transcranial Doppler recordings were obtained for 2 to 5 minutes after allowing approximately ...

PURPOSE: Delayed cerebral ischemia (DCI) and vasospasm are the main challenges contributing to unfavorable outcomes following aneurysmal subarachnoid hemorrhage. Nimodipine has been shown to decrease the incidence of delayed cerebral ischemia and improve outcomes. In patients who are unable to swallow, nimodipine tablets are crushed and administered through enteral feeding tubes. However, it is not clear whether this may result in reduced clinical effectiveness. The aims of the study were to investigate the impact of nimodipine administration through enteral feeding tubes, in the first 7 days and over the 21-days period on patient outcomes. METHODS: A retrospective chart review of subarachnoid hemorrhage patients admitted at the University of Alberta Hospital, Edmonton, Alberta, Canada was carried out. Logistic regression modelling was utilized to identify predictors of vasospasm and delayed cerebral ischemia. Main outcome measures were angiographic evidence of moderate to severe vasospasm, ...

AIM: Cerebral vasospasm after subarachnoid hemorrhage (SAH) is an important cause of morbidity and mortality. In this study, we examined the effects of L-carnitine on the cerebral vasospasm process. ...

2. It has been found that majority of the cases are of Grade 1&2, followed by Grade 4&5, and least are contribute by Grade 3.. According to Delveinsight, Aneurysmal Subarachnoid Hemorrhage (aSAH) is more common in females.. Aneurysmal Subarachnoid Hemorrhage (aSAH) is a serious condition that not just affects the brain, but multiple other organ systems as well. Despite a steady reduction of mortality from acute SAH in recent years, from over half to approximately one-third, this entity is still associated with considerable morbidity and mortality.. Aneurysmal subarachnoid hemorrhage (aSAH) is a worldwide health burden with high fatality and permanent disability rates. These aneurysms, located at the branching point of proximal intracranial arteries, are not uncommon and found in about 2% of the adult population (and even more frequently in those with a family history of aSAH or polycystic kidney disease).. Risk factors for aneurysm rupture include hypertension, smoking, heavy alcohol use, and ...

There is no evidence on the best time for surgical treatment of aneurysmal subarachnoid haemorrhage. Aneurysmal subarachnoid haemorrhage is a life-threatening condition. It is due to the bursting of an aneurysm (a weakness in the wall of a blood vessel in the brain). This can be treated by a surgical operation to place a clip over the aneurysm neck. There is uncertainty about whether to perform the operation immediately, or to wait a few days. The review found only one randomised trial which assessed the effect of the timing of surgery. From the limited evidence available, the timing of surgery was not a critical factor in determining the outcome from an aneurysmal subarachnoid haemorrhage, but further research is needed.. ...

TY - JOUR. T1 - Focal Neurological Deficit at Onset of Aneurysmal Subarachnoid Hemorrhage. T2 - Frequency and Causes. AU - Behrouz, Réza. AU - Birnbaum, Lee A.. AU - Jones, Pearl M.. AU - Topel, Christopher Hans. AU - Misra, Vivek. AU - Rabinstein, Alejandro A.. PY - 2016/4/15. Y1 - 2016/4/15. N2 - Background and Aim: Focal neurological deficit (FND) is a recognized presenting symptom of aneurysmal subarachnoid hemorrhage (SAH). However, little is known on how often aneurysmal SAH patients present with FND and what the responsible mechanisms are. The aim of this study was to examine the frequency and causes of FND at onset in aneurysmal SAH. Methods: We reviewed the records of consecutive aneurysmal SAH patients over 5 years and identified those who presented with FND. We developed several potential mechanisms for FND based on consensus between 2 separate evaluating neurologists. We then compared the characteristics of aneurysmal SAH patients who presented with and without FND. Logistic ...

RCVS is a cerebrovascular disorder that can be occur as late as 3 weeks after an uncomplicated pregnancy, characteristic neuroimaging finding accompanied by severe and acute headache are important key features to consider RCVS diagnosis.. Here were present a 39-year-old woman, presented with headache and subsequent right hemiparesis 3 weeks after abortion. First brain CT scan was unremarkable. Brain CT angiography showed multiple segmental stenosis and at later scans, she developed sub arachnid hemorrhage (SAH) which is a pathognomonic feature of RCVS. She was treated with calcium channel blocker and headache relieved and hemiparesis was improved. Final diagnosis was made based on normal trans-cranial Doppler (TCD) study after 4 weeks of symptoms onset.. ...

TY - JOUR. T1 - Ryanodine Receptor 1 Polymorphism Is Not Associated with Aneurysmal Subarachnoid Hemorrhage or its Clinical Sequelae. AU - Hendrix, Philipp. AU - Foreman, Paul M.. AU - Harrigan, Mark R.. AU - Fisher, Winfield S.. AU - Vyas, Nilesh A.. AU - Lipsky, Robert H.. AU - Lin, Minkuan. AU - Walters, Beverly C.. AU - Tubbs, R. Shane. AU - Mohajel Shoja, Mohammadali. AU - Pittet, Jean Francois. AU - Mathru, Mali. AU - Griessenauer, Christoph J.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Objective The pathophysiologic mechanisms underlying cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) remain poorly understand. Ryanodine receptors (RYR) are intracellular calcium channels involved in the regulation of vascular smooth muscle cells and cerebrovascular tone and diameter. Previous work reported an association between an RYR polymorphism and cerebral vasospasm. Here, we sought to assess the impact of that RYR polymorphism on aSAH and its clinical sequelae. Methods Blood samples from ...

TY - JOUR. T1 - Role of brain natriuretic peptide in cerebral vasospasm. AU - Sviri, Gill. AU - Shik, V.. AU - Raz, B.. AU - Soustiel, J. F.. AU - Doczi, T.. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Background. Brain natriuretic peptide (BNP) is a potent natriuretic factor responsible for hyponatremia observed in patients with SAH. Through its systemic effects (reduction of blood volume and blood pressure) BNP may augment cerebral blood flow reduction and ischemia secondary to vasospasm. The purpose of the present study was to evaluate the relationship between BNP plasma concentration during the first 12 days following SAH and the development of cerebral vasospasm (CVS). The authors propose a hypothesis for the role played by natriuretic peptides in the pathophysiology of cerebral vasospasm based on the present findings and review the literature. Methods. Thirty eight patients with spontaneous SAH were prospectively included in the present study. BNP plasma concentrations were assessed at four ...

Abstract Prophylactic use of hypervolemia and hypertension is believed to present an option to decrease the incidence of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage and improve neurologic outcome. A Medline literature search was conducted to review available evidence regarding volume management after subarachnoid hemorrhage. Quality of selected studies was evaluated, using the standardized GRADE system. Eleven studies focused on prophylactic hypervolemic therapy after aneurysmal subarachnoid hemorrhage were identified, including four randomized controlled trials. Available studies showed a large heterogeneity in physiologic treatment goals and interventions applied. The oldest and smallest randomized controlled trial suggested a positive effect, but had severe limitations in trial design. Neither of the other randomized controlled studies showed outcome benefit with hypervolemic therapy. Results from observational studies were not found to support the use of prophylactic ...

Title: Predictors of early and late vasospasm in Aneurysmal Subarachnoid Hemorrhage. Background:The peak incidence of vasospasm in aneurysmal subarachnoid hemorrhage occurs between the fourth and 10th day post bleed, occurring in up to 70% of patients.1 Occasionally patients develop early (within 48 hours) or late (beyond 10 days) from initial aneurysm rupture. Different mechanisms account for the temporal differences in occurrence of vasospasm in aneurysmal subarachnoid hemorrhage.2 The purpose of this study is to determine predictors of early and late vasospasm to select patients who may benefit from early intervention (for patients at risk for early vasospasm) or prolonged observation (for patients at risk for late vasospasm). Hypothesis:We hypothesize that we can identify clinical predictors of early and late vasospasm in aneurysmal subarachnoid hemorrhage. Methods: 226 consecutive patients with aneurysmal subarachnoid hemorrhage who developed vasospasm were studied. Patients were grouped ...

Wellington, New Zealand: download cerebral. Ministry of Social Development. sizes provided download cerebral vasospasm neurovascular events after subarachnoid hemorrhage due: complexities and rocks. centering to be node in client energy. British Journal of Social Work, dry), 1135-1151. Indian performance in the own clean-shaven correlation of the Department of workshops. Social Work Review, Cornish), 8-15. The download cerebral vasospasm neurovascular of analysis explains on the 0016-7037(81)90120-4Get of product. cancer; agency Bayes, work metals, or sourced efforts. verifying more than one customers leaving download cerebral vasospasm neurovascular events after subarachnoid over the large collection share is a subsperical story, since the best everyone can be driven for longitudes. In depiction to in-house KPIs that about do interested or at best the open goal, geothermal KPI fulfills about and cite loci achieving to See what the analysis will make in the bitter software, employment, or ...

TY - JOUR. T1 - Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. AU - Roa, Jorge A.. AU - Sarkar, Deepon. AU - Zanaty, Mario. AU - Ishii, Daizo. AU - Lu, Yongjun. AU - Karandikar, Nitin J.. AU - Hasan, David M.. AU - Ortega, Sterling B.. AU - Samaniego, Edgar A.. N1 - Funding Information: Teresa Ruggle for graphic design and preparation. This work was supported by the 2019 Brain Aneurysm Research Grant from The Bee Foundation and by a Pilot Research Grant from the Society of Vascular and Interventional Neurology (SVIN), both granted to Edgar Samaniego. Publisher Copyright: © 2020, The Author(s).. PY - 2020/12/1. Y1 - 2020/12/1. N2 - Cerebral vasospasm (VSP) is a common phenomenon after aneurysmal subarachnoid hemorrhage (aSAH) and contributes to neurocognitive decline. The natural history of the pro-inflammatory immune response after aSAH has not been prospectively studied in human cerebrospinal fluid (CSF). In this pilot study, we aimed to ...

도서관에서 가져오기! Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage. [Mario Zuccarello;] -- The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held in Cincinnati, Ohio, USA, in July 2011. This collection of papers represents a cross-section of ...

TY - JOUR. T1 - Impact of cardiac complications on outcome after aneurysmal subarachnoid hemorrhage. T2 - a meta-analysis. AU - van der Bilt, I A C. AU - Hasan, D. AU - Vandertop, W P. AU - Wilde, A A M. AU - Algra, A. AU - Visser, F C. AU - Rinkel, G J E. PY - 2009/2/17. Y1 - 2009/2/17. N2 - UNLABELLED: Impact of cardiac complications after aneurysmal subarachnoid hemorrhage (SAH) remains controversial. We performed a meta-analysis to assess whether EKG changes, myocardial damage, or echocardiographic wall motion abnormalities (WMAs) are related to death, poor outcome (death or dependency), or delayed cerebral ischemia (DCI) after SAH.METHODS: Articles on cardiac abnormalities after aneurysmal SAH that met predefined criteria and were published between 1960 and 2007 were retrieved. We assessed the quality of reports and extracted data on patient characteristics, cardiac abnormalities, and outcome measurements. Poor outcome was defined as death or dependence by the Glasgow Outcome Scale ...

TY - JOUR. T1 - Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies. T2 - proposal of a multidisciplinary research group.. AU - Vergouwen, Mervyn D I. AU - Vermeulen, Marinus. AU - van Gijn, Jan. AU - Rinkel, Gabriel J E. AU - Wijdicks, Eelco F.. AU - Muizelaar, J. Paul. AU - Mendelow, A. David. AU - Juvela, Seppo. AU - Yonas, Howard. AU - Terbrugge, Karel G.. AU - Macdonald, R. Loch. AU - Diringer, Michael N.. AU - Broderick, Joseph P.. AU - Dreier, Jens P.. AU - Roos, Yvo B W E M. PY - 2010/10. Y1 - 2010/10. N2 - BACKGROUND AND PURPOSE: In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinical features of cerebral ischemia, although multiple factors may contribute ...

Abstract Apoptosis in the endothelium of major cerebral arteries may play a role in the initiation and maintenance of cerebral vasospasm after subarachnoid hemorrhage (SAH). We tes..

TY - JOUR. T1 - Multimodal MRI characterization of experimental subarachnoid hemorrhage. AU - Sun, Y.. AU - Shen, Q.. AU - Watts, L. T.. AU - Muir, E. R.. AU - Huang, S.. AU - Yang, G. Y.. AU - Suarez, J. I.. AU - Duong, T. Q.. N1 - Funding Information: This work was funded in part by NIH/NINDS (R01-NS45879). Y.S. and G.Y. were funded in part by peer-reviewed grants in aid from the National Natural Science Foundation of China (81270856, 81301045, 81471176), and SJTU Medical-Engineering Cross Research fund (YG2012MS06). Publisher Copyright: © 2015 IBRO.. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Subarachnoid hemorrhage (SAH) is associated with significant morbidity and mortality. We implemented an in-scanner rat model of mild SAH in which blood or vehicle was injected into the cistern magna, and applied multimodal MRI to study the brain prior to, immediately after (5min to 4h), and upto 7days after SAH. Vehicle injection did not change arterial lumen diameter, apparent diffusion coefficient (ADC), T2, ...

TY - JOUR. T1 - Outcome after clipping and coiling for aneurysmal subarachnoid hemorrhage in clinical practice in Europe, Usa, and Australia. AU - Lindgren, Antti. AU - Turner, Ellie Bragan. AU - Sillekens, Tomas. AU - Meretoja, Atte. AU - Lee, Jin Moo. AU - Hemmen, Thomas M.. AU - Koivisto, Timo. AU - Alberts, Mark. AU - Lemmens, Robin. AU - Jääskeläinen, Juha E.. AU - Vergouwen, Mervyn D.I.. AU - Rinkel, Gabriel J.E.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background:Within randomized clinical trials (RCTs), coiling of the ruptured aneurysm to prevent rebleeding results in better outcomes than clipping in patients with aneurysmal subarachnoid hemorrhage (aSAH). Objective: To study the association of coiling and clipping with outcome after aSAH in daily clinical practice. Methods: In this controlled, nonrandomized study, we compared outcomes after endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in an administrative dataset of 7658 aSAH patients (22 tertiary ...

TY - JOUR. T1 - Concurrence of aneurysmal subarachnoid hemorrhage and stanford type A acute aortic dissection. AU - Inamasu, Joji. AU - Suzuki, Takeya. AU - Wakako, Akira. AU - Sadato, Akiyo. AU - Hirose, Yuichi. PY - 2016/6/1. Y1 - 2016/6/1. N2 - We report a rare case of concurrent aneurysmal subarachnoid hemorrhage (SAH) and acute aortic dissection (AAD). A 38-year-old man visited our hospital complaining of severe headache, and brain computed tomography (CT) revealed the presence of SAH. Thoracic to neck computed tomography angiography (CTA), performed in addition to brain CTA, suggested a tear in the aortic arch, and subsequent CT aortography established the diagnosis of Stanford type A AAD. The AAD in our patient, who reported no episodes of chest or back pain, was detected incidentally by thoracic to neck CTA. The imaging study has rarely been indicated for SAH except that it provides additional anatomical information in patients for whom extracranial-intracranial bypass surgery or ...

Inflammatory Pathways Following Subarachnoid Hemorrhage. Cell Mol Neurobiol. 2019 Dec 05;: Authors: Khey KMW, Huard A, Mahmoud SH Abstract Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular emergency resulting from the rupture of a brain aneurysm. Despite only accounting for 5% of all strokes, SAH imposes a significant health burden on society due to its rel...

Subarachnoid hemorrhage (SAH) develops when extravasated arterial blood enters subarachnoid space and mixes with cerebrospinal fluid. As a result, much pathology develops, including arterial vasospasm leading to neuronal ischemia resulting in neurological deficits. Cerebral arteries may be constricted both directly by cytokine influence on arterial smooth muscles and indirectly, through increase of endothelin-1 (ET-1) synthesis or adhesion molecules production. Interleukin-1β (IL-1β) is secreted following SAH and through broken bloodbrain barrier it may lead to the stimulation of peripheral leukocytes. These peripheral mononuclear cells (PMC) may be an additional source of ET-1 and migrating to the brain they can enhance the vasospasm. We examined effect of neutralization of IL-1β on secretion of ET-1 by PMCs as well as on basilar artery vasospasm in rats following SAH. SAH was produced by injection of 150 μL of autologous arterial blood into cisterna magna. In 50% of animals, IL-1β ...

Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is an acute cerebrovascular event which can have devastating effects on the central nervous system as well as a profound impact on several other organs. SAH patients are routinely admitted to an intensive care unit and are cared for by a multidisciplinary team. A lack of high quality data has led to numerous approaches to management and limited guidance on choosing among them. Existing guidelines emphasize risk factors, prevention, natural history, and prevention of rebleeding, but provide limited discussion of the complex critical care issues involved in the care of SAH patients. The Neurocritical Care Society organized an international, multidisciplinary consensus conference on the critical care management of SAH to address this need. Experts from neurocritical care, neurosurgery, neurology, interventional neuroradiology, and neuroanesthesiology from Europe and North America were recruited based on their publications and expertise. A jury of four experienced ...

Predictors and outcome of acute symptomatic cerebral infarctions following aneurysmal subarachnoid hemorrhage. Feng-Wen Su; Yu-Jun Lin; Wen-Neng Chang; Jih-Tsun Ho; Hung-Chen Wang; Tzu-Ming Yang; Thung-Ming Su; Wei-Che Lin; Nai-Wen Tsai; Yu-Ling Ding; Cheng-Hsien Lu // Journal of Neurology;Feb2010, Vol. 257 Issue 2, p264 The leading cause of unfavorable outcomes following aneurysmal subarachnoid hemorrhage (SAH) is cerebral infarction. In this 3-year retrospective study, we have retrospectively evaluated 172 hospitalized patients with aneurysmal SAH, and compared those who developed a complicated cerebral... ...

The exact relationship between delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and neuropsychological impairment remains unknown, as previous studies lacked a baseline examination after aneurysm occlusion but before the DCI-period. Neuropsychological evaluation of acutely ill patients is often applied in a busy intensive care unit (ICU), where distraction represents a bias to the obtained results.; To evaluate the relationship between DCI and neuropsychological outcome after aSAH by comparing the Montreal Cognitive Assessment (MoCA) results in aSAH patients with and without DCI at 3 mo with a baseline examination before the DCI-period (part 1). To determine the reliability of the MoCA, when applied in an ICU setting (part 2).; Prospective, multicenter, and observational study performed at all Swiss neurovascular centers. For part 1, n = 240 consecutive aSAH patients and for part 2, n = 50 patients with acute brain injury are recruited.; Part 1: Effect size of ...