The ability of lysoPC, either independently or as a component of oxidized LDL, to inhibit endothelial-dependent vasorelaxation is well established (Cowan and Steffen, 1995; Freeman et al., 1996). The effect of lysoPC to impair endothelium-dependent relaxation is generalized to a variety of endothelium-dependent vasodilators, including acetylcholine (Kugiyama et al., 1990), 5-hyroxytryptamine (Cox and Cohen, 1996a), thrombin (Murohara et al., 1994) and calcium ionophore A23187 (Mangin et al., 1993). However, the cellular pathways affected by lysoPC that ultimately result in endothelial vasomotor dysfunction remain unclear. LysoPC was recently documented to stimulate PLD activity in cultured human endothelial cells (Cox and Cohen, 1996c), although the role of this effect in the vasomotor actions of lysoPC was not addressed. The present study has demonstrated the ability of lysoPC to stimulate vascular PLD activity in isolated blood vessels and has documented a close association between the ability ...
Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease. Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46±8 to 114±11 μmol/L, P=.001). In the prospectively defined group of patients with an abnormal baseline response (,5% dilation), ascorbic acid produced marked improvement in dilation (2.0±0.6% to 9.7±2.0%), whereas placebo had no effect (1.1±1.5% to 1.7±1.5%, P=.003 for ascorbic acid ...
Alpha-tocopherol, a lipid soluble antioxidant, has been shown to protect endothelial cells against oxidative damage (18-21). Previous reports showed that alpha-tocopherol supplementation restored endothelial function in parallel with suppression of lipid peroxidation in low density lipoproteins (LDL) in experimental hypercholesterolemic animals (19,21). In this regard, the present study also showed that the improvement of endothelium-dependent vasodilation was associated with decrease in plasma TBARS levels, an indicator of lipid peroxidation, after alpha-tocopherol treatment in patients with high remnants levels. This strongly suggests that the beneficial effect of alpha-tocopherol, as shown in the present study, was at least partly mediated through prevention of endothelial function from oxidative stress-induced injury in patients with high remnant lipoproteins levels. We have previously shown that oxidatively modified LDL causes endothelial dysfunction and has an important role in ...
Today versatility of non-invasive photonic techniques has been developed to measure real-time characteristics of haemodynamics and microvascular system in health and pathology conditions in different organs and tissues. Compact laser instruments for near-infrared spectroscopy (NIRS), Laser Doppler Flowmetry (LDF), diffuse correlation spectroscopy (DCS), NIRS flow oximetry, Raman spectroscopy, and others are used now for non-invasive rapid measurement of different parameters of haemocirculation such as blood flow, mean arterial pressure, oxy- and deoxyhemoglobin concentrations and others. Development and introduction of these methods to clinic lead to step-by-step substitution of laboratory analysis and enable bed-side diagnostics. Design of hybrid optical techniques and their combination with imaging tissues and organs by optical coherence tomography allows measuring dynamic characteristics of complex functionality and regulation of microvascular systems in health and pathology. Today
The Brainstem lies at the base of the brain and the top of the spinal cord. It houses many of the control centres for vital body functions, such as swallowing, breathing, and vasomotor control. The 3 structures of the brainstem are coloured in diagram to right.
Susceptibility to tumor advancement varies among mice strains. is certainly dominant-resistant against NIH [1, 2]. A locus was mapped by examining the Car-R and Car-S crosses [13] also, which were produced by the well balanced intercross of eight inbred strains, including A/J, BALB/C, SJL/J, SWR/J, C57BL/6J, CBA/J, P/J and DBA/2 [9]. had been mapped with […]. ...
Purpose The purpose of this study was to research the prognostic need for the expression of p53 gene product in operable invasive breast cancer by performing immunohistochemical analysis. subgroup evaluation, the p53 non-expressors demonstrated better 7-calendar year overall success (92.7% vs. 76.7%, respectively, p=0.011) and relapse free of charge Glucagon (19-29), human supplier success (74.9% […]. ...
TY - JOUR. T1 - High-dose atorvastatin enhances impaired cerebral vasomotor reactivity. AU - Forteza, Alejandro. AU - Romano, Jose G.. AU - Campo-Bustillo, Iszet. AU - Campo, Nelly. AU - Haussen, Diogo C.. AU - Gutierrez, Jose. AU - Koch, Sebastian. PY - 2012/8/1. Y1 - 2012/8/1. N2 - The influence of statin therapy on cerebral vasomotor function has not been fully characterized. We report the effects of high-dose atorvastatin therapy on cerebral vasomotor reactivity (VMR) in patients with controlled hypertension and dyslipidemia. We prospectively enrolled 36 patients with controlled hypertension and a low-density lipoprotein (LDL) cholesterol concentration ,100 mg/dL. Atorvastatin 80 mg was given daily for 6 months and then discontinued. VMR was assessed by hypercapnic and hypocapnic transcranial Doppler challenge in both the right and left middle cerebral artery (MCA) at baseline, and after 3 and 6 months of therapy. Forty-five days after statin cessation, a repeat VMR was performed. VMR ...
Physiological aspects. At rest two major spectral components characterize heart rate variability: the low frequency component: (LFRR , ~0.1 Hz , in normalized units, n.u.) which quantifies the sympathetic modulation of the seno-atrial node and the high frequency component (HFRR, ~0.25 Hz) an index of the cardiac vagal modulation. The low frequency component of systolic arterial pressure variability (LFSAP) is a marker of the sympathetic vasomotor regulation.. Changes in these markers over 24 hours (Circulation 1990;81:537-547), during the up-right position (Circulation 2000;101:886-892), mental stress (J Auton Nerv Syst 1991;35:33-42), shift work (Circulation 2000;102:1912-1916), or following physical training (Cardiovasc Res 1993;27:482-488), have furnished valuable non-invasive information on the autonomic modifications attending different functional conditions in healthy subjects.. - Pathophysiological aspects. Since the beginning of the nineties and more recently, Dr Furlan used power ...
Physiological aspects. At rest two major spectral components characterize heart rate variability: the low frequency component: (LFRR , ~0.1 Hz , in normalized units, n.u.) which quantifies the sympathetic modulation of the seno-atrial node and the high frequency component (HFRR, ~0.25 Hz) an index of the cardiac vagal modulation. The low frequency component of systolic arterial pressure variability (LFSAP) is a marker of the sympathetic vasomotor regulation.. Changes in these markers over 24 hours (Circulation 1990;81:537-547), during the up-right position (Circulation 2000;101:886-892), mental stress (J Auton Nerv Syst 1991;35:33-42), shift work (Circulation 2000;102:1912-1916), or following physical training (Cardiovasc Res 1993;27:482-488), have furnished valuable non-invasive information on the autonomic modifications attending different functional conditions in healthy subjects.. - Pathophysiological aspects. Since the beginning of the nineties and more recently, Dr Furlan used power ...
1. In an effort to obtain some information concerning the chemical nature of "liver sympathin" ("sympathin E" of Cannon and Rosenblueth), we have compared directly, in the same animal, the responses evoked by injected dl-nor-epinephrine [β-(3,4-dihydroxyphenyl)-β-hydroxyethylamine] and l-epinephrine with those induced by "liver sympathin" (stimulation of the hepatic nerves).. 2. The responses of the following effector systems to these agents were studied in the cat, under dial (Ciba) anesthesia, with the vagi sectioned and the adrenals ablated:. a. Vasomotor system.. b. Vasomotor system after the administration of ergotoxine (or ergotamine).. c. Nictitating membrane (sensitized).. d. Uterus, non-pregnant and pregnant.. e. Iris.. f. Intestine.. 3. It is concluded that the responses to dl-nor-epinephrine are strikingly similar to those induced by "liver sympathin.". 4. Certain variations in the responses to nor-epinephrine and "liver sympathin" are considered and reasons suggested ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Menopause is a critical stage of womens life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, s...
DESIGN:. Imaging and vasomotion Substudy:. 50 consecutive patients enrolled in the COMPARE II trial at the University of Fribourg Medical Center will undergo follow-up re-angiography 14 months after index procedure with assessment of Optical coherence tomography (OCT) and vasomotion testing.. ENDPOINT SUBSTUDY (all at 14 months):. Primary endpoint imaging: percentage of uncovered stent struts per lesion and mean neointimal thickness assessed by OCT.. vasomotion: coronary vasomotion assessed with quantitative coronary angiography at rest and during supine bicycle exercise. ...
Lynoral (ethinylestradiol) is most often used as estrogen containing component of combined oral contraceptives. The drug is also used for the treatment of symptoms of menopause and post-menopause, especially vasomotor effects.. While using this drug, the contraception is due to several interrelated influences.. Ovulation is inhibited at the regulatory level of the hypothalamus.. Cervical changes a secret, it generates the expulsion of sperm.. Also it changes the endometrium, making implantation of a fertilized egg impossible.. Dienogest binds to blood albumin, but it is not associated with blood globulin that binds sex hormones of the woman. Also, the contraceptive does not interact with the globulin that binds corticoids. Dienogest is excreted in the bile and urine. The half-excretion of the drug requires from eight and a half to eleven hours. When a woman takes the contraceptive, the level of drug in the blood serum becomes more than in 1.5 times.. ...
Chlorothiazide decreases plasma volume, heart size, and cardiac output. The oligemia stimulates vasomotor tone; this tends to maintain arterial pressure because chronic arterial hypertension is characteristically self-sustaining and homeostatic. This oligemic stimulation of vasomotor tone results in increased sensitivity to the antihypertensive effect of drugs depressing or blocking vasomotor function.. ...
TY - JOUR. T1 - Protective effect of extracellular superoxide dismutase on endothelial function during aging. AU - Lund, Donald D.. AU - Chu, Yi. AU - Miller, Jordan D. AU - Heistad, Donald D.. PY - 2009/6. Y1 - 2009/6. N2 - Endothelial vasomotor function decreases with increasing age. Extracellular superoxide dismutase (ecSOD) protects against vascular dysfunction in several disease states. The purpose of this study was to determine whether endogenous ecSOD protects against endothelial dysfunction in old mice. Vasomotor function of the aorta was studied ex vivo in wild-type (ecSOD +/+) and ecSOD-deficient (ecSOD -/-) mice at 11 (adult) and 29 (old) mo of age. Maximal relaxation to acetylcholine (10 -4 M) was impaired in vessels from adult ecSOD -/- mice [75 ± 3% (mean ± SE)] compared with wild-type mice (89 ± 2%, P , 0.05). Maximal relaxation to acetylcholine (10 -4 M) was profoundly impaired in aorta from old ecSOD -/- mice (45 ± 5%) compared with wild-type mice (75 ± 4%, P , 0.05). There ...
are also real and exist. Recent studies have shown a correlation between tea drinking and reduce cardiovascular disease events, such as acute myocardial infarction and stroke. A study conducted by Boston University in 2001 concluded that this effect was due to components in black tea reversing endothelial vasomotor dysfunction, reducing the possibility of dangerous cardiovascular events. In addition, a compound known as theaflavin-3-gallate has shown promise in reducing the incorporation of cholesterol into mixed micelles. These micelles are responsible for absorbing cholesterol into the body, and blocking such an event may help with cholesterol levels, even if in modest levels. However, to gain these benefits, black tea must be drunk without milk. A German study in 2006 showed that milk cancels out these health benefits. This is likely because the casein proteins in milk bind to the active components in tea that have the purported health benefits. Plus, a study conducted by the University ...
are also real and exist. Recent studies have shown a correlation between tea drinking and reduce cardiovascular disease events, such as acute myocardial infarction and stroke. A study conducted by Boston University in 2001 concluded that this effect was due to components in black tea reversing endothelial vasomotor dysfunction, reducing the possibility of dangerous cardiovascular events. In addition, a compound known as theaflavin-3-gallate has shown promise in reducing the incorporation of cholesterol into mixed micelles. These micelles are responsible for absorbing cholesterol into the body, and blocking such an event may help with cholesterol levels, even if in modest levels. However, to gain these benefits, black tea must be drunk without milk. A German study in 2006 showed that milk cancels out these health benefits. This is likely because the casein proteins in milk bind to the active components in tea that have the purported health benefits. Plus, a study conducted by the University ...
Publications. Hanby MF, Panerai RB, Robinson TG, Haunton VJ (2017) Is cerebral vasomotor reactivity impaired in Parkinson disease?. Clinical Autonomic Research, 27 (2), pp. 107-111 10.1007/s10286-017-0406-x. Caldas J, Panerai RB, Bor-Seng-Shu E, Almeida J, Ferreira G, Cunha L, Nogueira R, Oliveira M, Jatene F, Robinson T, Hajjar L (2017) Cerebral hemodynamic with intra-aortic balloon pump: business as usual?. Physiological measurement, 10.1088/1361-6579/aa68c4. Nogueira RC, Panerai RB, Teixeira MJ, Robinson TG, Bor-Seng-Shu E (2017) Cerebral Hemodynamic Effects of Cheyne-Stokes Respiration in a Patient with Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 10.1016/j.jstrokecerebrovasdis.2017.02.026. Caldas JR, Panerai RB, Haunton VJ, Almeida JP, Ferreira GSR, Camara L, Nogueira RC, Bor-Seng-Shu E, Oliveira ML, Groehs RRV, Ferreira-Santos L, Teixeira MJ, Galas FRBG, Robinson TG, Jatene FB, Hajjar LA (2017) Cerebral blood flow ...
There has in the past been no method of thermometry that is considered by patients and clinicians to be comfortable, convenient, and accurate. Rectal, oral, axilla, and ear thermometry all have either significant discomfort due to the use of a body cavity, artifactual inaccuracies due to physiological/device phenomena, or both, thus making them less than desirable for the needs of both patient and clinician. The exposed skin eliminates the use of a body cavity, but an accurate method using the skin has heretofore not been demonstrated.. The superficial temporal artery demonstrates the necessary requirements for the skin thermometry method: it is easily accessible, contains no mucous membranes, and notably, it has no or very few arteriovenous anastomoses (AVA).1,2 Lack of AVAs means that perfusion rate is reliable under essentially all conditions, and the blood flow is relatively free of vasomotor control in response to thermomoregulatory stimuli. This property is unique to the temporal artery ...
This page includes the following topics and synonyms: Vasomotor Symptoms of Menopause, Hot Flashes, Hot Flushes, Flushing, Menopausal Diaphoresis.
Oculomotor nerve stimulation causes vasoconstriction in the anterior uvea, which is due partly to a muscarinic mechanism and partly to a non-sympathetic aminergic mechanism. The labelled microsphere method was used to analyze the effect of pentobarbital anesthesia on the resting cholinergic vasomotor tone in the anterior uvea and to determine the relationship between stimulation frequency and vasomotor response. An attempt was made also to ascertain whether the aminergic part of the vasoconstriction is caused by release of 5-hydroxytryptamine or norepinephrine. Induction of pentobarbital anesthesia caused a marked vasodilation in the iris and the ciliary processes and a subsequent muscarinic blockade had no effect on the blood flow. A similar result was obtained in the optic nerve. In the choroid plexus, heart muscle, pineal body and coecum, pentobarbital anesthesia caused vasodilation and a subsequent muscarinic blockade caused vasoconstriction. In the brain pentobarbital anesthesia caused a marked
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Thromboxane is a vasoactive omega-6-derived lipid implicated in hypertension. Omega-3 fatty acid derivatives including resolvin (Rv) E1 have important roles in the resolution of inflammation, but their ability to mediate vasomotor activity is unknown. We assessed whether RvE1 modulates contraction of rat thoracic aorta and human pulmonary artery (HPA) in vitro.. Rats were culled by CO2 inhalation and cervical dislocation, and the thoracic aorta was removed. HPA were obtained with informed consent from lung tissue of surgical patients at Southampton General Hospital. Segments of aorta or HPA were incubated in DMEM-F12 with or without RvE1 (10 nM, 100 nM or 300 nM) for 1 or 24 hours, and then mounted on a wire myograph. Mounted segments were bathed at 37[[Unable to Display Character: ]]C in Krebs buffer, gassed (95%/5% O2/CO2) and set to 1.5 g of baseline tension. Functional integrity was confirmed by a contractile response to 125 mM KPSS. After washing to restore baseline tension, a ...
This study is investigating the effect of everolimus drug-eluting stent [Xience Prime] versus everolimus bioresorbable vascular scaffold [Absorb] on vasomotor
While about 80% of peri- and postmenopausal women have vasomotor symptoms (VMS), such as night sweats and hot flashes, it has been observed that higher body mass index (BMI) and body fat are associated with an increased risk of vasomotor symptoms. Thus, it is reasonable to speculate that weight loss may prevent VMS.. In a recent study, researchers analyzed data from 1,546 participants in the Study of Womens Health Across the Nation (SWAN). In this population, they found that women in early menopause who have a higher BMI and waist circumference were more likely to report VMS and to have more frequent VMS. In contrast, for women in late menopause, higher BMI and waist circumference were associated with fewer VMS. Furthermore, they observed that weight loss did not result in a reduction in VMS.. These findings differ from those reported from the dietary intervention trial of the Womens Health Initiative (WHI), where it was observed that in postmenopausal women, VMS were reduced or "eliminated" ...
Metabolic syndrome (MetS), which is rapidly becoming prevalent worldwide, is long known to be associated with hypertension and recently with oxidative stress. Of note is that oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, contributes to sympathoexcitation and hypertension. This study sought to identify the source of tissue oxidative stress in RVLM and their roles in neural mechanism of hypertension associated with MetS. Adult normotensive rats subjected to a high-fructose diet for 8 weeks developed metabolic traits of MetS, alongside increases in sympathetic vasomotor activity and blood pressure. In RVLM of these MetS rats, the tissue level of reactive oxygen species was increased, nitric oxide (NO) was decreased, and mitochondrial electron transport capacity was reduced. Whereas the protein expression of neuronal NO synthase (nNOS) or protein inhibitor of nNOS was increased, the ratio of nNOS dimer/monomer was significantly decreased. ...
Menopause is associated with a cluster of issues. Vasomotor symptoms (VMS) are the number one complaint of most menopausal women.
In the present study, we sought to identify if a vascular amplifier was contributing to the heightened depressor responses to ganglionic blockade and the increased LF oscillations in SBP that we have previously reported in the hypertensive LPK model of CKD (Phillips et al. 2007; Harrison et al. 2010; Hildreth et al. 2013). Our findings indicate that sympathetic overactivity prevails over any presence of a vascular amplifier in this model.. In the LPK rats, the normalized depressor response to ganglionic blockade was greater than that seen in the Lewis controls for either of the direct acting vasodilators: SNP or adenosine, indicating that in this model of CKD, the enhanced depressor response is reflective of increased sympathetic vasomotor tone. This was evident when responses were assessed for both MAP and SBP. Our data, however, do not rule out a role of the vasculature in contributing to the maintained hypertension in this model, highlighted in particular by the finding that following ...
Black cohosh alone or combined with other botanical agents doesnt seem to relieve the vasomotor symptoms of menopause better than placebo. A five arm trial was carried out on 351 women aged 45-55 who had at least two vasomotor symptoms each day at baseline. Women were randomised to receive black cohosh; … ...
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Intracellular calcium (Ca2+) concentration exhibits periodic oscillations in vascular smooth muscle cells. This is thought to result from Ca2+ release from intracellular stores, due to inositol triphosphate and ryanodine-sensitive channel activation. This activation has been shown to result in either Ca2+ "sparks", highly localized calcium increases, or "waves", global Ca2+ increase that propagates the length of the cell.[3] To allow vasomotion to occur, synchronization must occur between the individual oscillations, resulting in global calcium synchronization and vessel tone oscillation.[4] Gap junctions are thought to play a large role in this synchronization, as application of gap junction blockers has been shown to abolish vasomotion, indicating a critical role.[5] Due to regional variations in gap junction distribution and coupling (homocellular vs. heterocellular) several hypotheses have been suggested to account for vasomotion occurrence. The "classic" mechanism of vasomotion generation ...
Hydrogen sulfide (H(2)S) is a potent vasodilator. However, the complex mechanisms of vasoregulation by H(2)S are not fully understood. We tested the hypotheses that (1) H(2)S exerts vasodilatory effects by opening KCNQ-type voltage-dependent (K(v)) K(+) channels and (2) that H(2)S-producing cystathionine-γ-lyase (CSE) in perivascular adipose tissue plays a major role ...