Human Trial of Vaginal Microbicide Gel PRO 2000 Finds Some Level of HIV Protection, at TheBody.com, the complete HIV/AIDS resource.
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The field of rectal and vaginal microbicides is a new therapeutic area with several candidates in clinical trials and no registered products. Many of these candidates, with the exception of a 1% tenofovir gel evaluated in the recent CAPRISA 004 trial (1), have failed to demonstrate safety or efficacy. Despite these setbacks, the field is still progressing rapidly due to the pressing need for prophylactic technologies and the advantages of vaginal route of delivery for antiretroviral drugs (9, 16). Typically, drugs delivered through the vaginal route encounter an acidic environment with pH ranging from 4.0 to 5.0 (37, 40). However, soon after intercourse, the vaginal pH increases to a neutral pH due to the introduction of semen. The vaginal environment also hosts several Lactobacillus strains that constantly generate lactic acid and hydrogen peroxide, maintaining an acidic pH in the vaginal cavity (37, 40). Therefore, successful development of a vaginal microbicide product requires an active ...
Approximately 112 HIV-negative women, aged 18 to 50, will be enrolled in this multicenter study at four sites. Volunteers will be randomized to dapivirine (TMC120) vaginal gel or matching placebo gel. The volunteers will receive investigational product for a total of 42 days. Volunteers will be monitored on days 7, 28 and 42 for safety, tolerability and compliance ...
HIV/AIDS is a global pandemic that has claimed the lives of 39 million people and currently afflicts 36.9 million more. These effects are disproportionately felt in sub-Saharan Africa which has almost 70% of those current cases and where women account for 59% of current infections. These numbers are even more disproportionate for young women and complications associated with HIV/AIDS are the leading cause of death in women aged 15-44. This creates a need for female-controlled tools to prevent infection. Microbicides are one such tool. Microbicides are vaginally-delivered topical products that combine a therapeutic agent with activity against HIV and a delivery vehicle. The delivery vehicle can consist of many different formulations, depending on the therapeutic agent used and the delivery mechanism desired. Polymer solutions (known as gels in the microbicide field) have received the most attention and have been incorporated into the most formulations for use in clinical trial evaluations. ...
Each gram of PREMARIN (conjugated estrogens) Vaginal Cream contains 0.625 mg conjugated estrogens, USP in a nonliquefying base containing cetyl esters wax, cetyl alcohol, white wax, glyceryl monostearate, propylene glycol monostearate, methyl stearate, benzyl alcohol, sodium lauryl sulfate, glycerin, and mineral oil. PREMARIN Vaginal Cream is applied intravaginally.. PREMARIN Vaginal Cream contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, sodium sulfate conjugates, 17 α-dihydroequilin, 17 α-estradiol, and 17 β-dihydroequilin.. ...
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The MHRP applauds results announced today that the Center for the AIDS Program of Research in South Africa (CAPRISA) 004 trial showed that a vaginal microbicide gel could safely and effectively reduce the risk of heterosexual transmission of HIV from men to vulnerable women. The microbicide containing 1% tenofovir-an antiretroviral drug widely used in the treatment of HIV-was
Two progesterone presentations, a vaginal application of 90 mg progesterone per day (Crinone) or 300 mg progesterone administered orally (Utrogestan), were compared for luteal phase support of patients undergoing an in-vitro fertilization (IVF) procedure. A total of 283 patients were randomly allocated to either treatment. The treatment started within 24 h after the embryo transfer procedure and continued until day 30 in cases of implantation. Efficacy was assessed using the pregnancy and delivery rates. Safety was assessed through specific symptoms and usual safety monitoring. The pregnancy rates per transfer were not significantly different in the Crinone and Utrogestan groups at days 12 (Crinone 35.3%, Utrogestan 29.9%, P = 0.55), 30 (Crinone 28.5%, Utrogestan 25.0%, P = 0.61) and 90 (Crinone 25.9%, Utrogestan 22.9%, P = 0.69). No differences in the spontaneous abortion rates were seen thereafter. The delivery rates (number of deliveries per patient; Crinone 23.0%, Utrogestan 22.2%, P = ...
TY - JOUR. T1 - Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques. AU - Pereira, Lara E.. AU - Mesquita, Pedro M.M.. AU - Ham, Anthony. AU - Singletary, Tyana. AU - Deyounks, Frank. AU - Martin, Amy. AU - McNicholl, Janet. AU - Buckheit, Karen W.. AU - Buckheit, Robert W.. AU - Smith, James M.. N1 - Publisher Copyright: © 2016, American Society for Microbiology. All Rights Reserved.. PY - 2016/3. Y1 - 2016/3. N2 - We evaluated the in vivo pharmacokinetics and used a complementary ex vivo coculture assay to determine the pharmacodynamics of IQB3002 gel containing 1% IQP-0528, a nonnucleoside reverse transcriptase inhibitor (NNRTI), in rhesus macaques (RM). The gel (1.5 ml) was applied vaginally to 6 simian-human immunodeficiency (SHIV)-positive female RM. Blood, vaginal fluids, and rectal fluids were collected at 0, 1, 2, and 4 h. RM were ...
To reduce the influence of adherence as a factor in the interpretation of efficacy results, IPM is considering using a DOT (Directly Observed Therapy) based method for vaginal microbicide gel delivery in a future Phase III study. IPM has denoted this DOT based method as Daily Monitored Adherence (DMA). IPM014B is a Phase I/II study designed: (1) to assess and compare the safety of a once daily application of Dapivirine Gel 4789, 0.05% 2.5g and a matching vehicle placebo gel; (2) to assess the acceptability of a once daily application of Dapivirine gel 4789, 0.05% 2.5g and a matching vehicle placebo gel; and (3) to assess the feasibility of utilizing the DMA method for a large-scale phase III efficacy study ...
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On July 19, here in Vienna at the XVIIIth International AIDS Conference, positive results were announced from the CAPRISA 004 Phase IIb microbicide trial of 1% tenofovir gel, which was tested in 889 South African women. Overall, there were 39 percent fewer infections among women who received the gel compared to women who received the placebo -and the results showed 51% efficacy of the gel against transmission of herpes simplex virusto women. Of note, recent vaccine trials and microbicide trials have set as a limit of efficacy 30% in order to be considered effective, which generally means that the FDA will approve them. This, of course, is great news and a real breakthrough. There have been several previous trials of vaginal microbicides which have not shown any efficacy. Its also great because its potentially female controlled, i.e., women can conceivably insert it vaginally and be protected if their husbands/partners force sex upon them. In addition, this could be a great intervention for ...
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But VOICE has now produced a negative result and the licensing of a vaginal microbicide has become a considerably more distant prospect, as approval may now depend on more than one future positive result.. Future plans. Other trials are nonetheless proceeding, as researchers dont yet know why no efficacy was found in VOICE and no safety issues were raised by the gel. The FACTS 001 trial is a South African study of tenofovir microbicide gel using the same before-and-after-sex regimen as CAPRISA 004. In has just started to enrol a planned 2,200 women at nine sites. In the middle of next year, the ASPIRE trial, a long-awaited efficacy trial of a vaginal ring impregnated with another anti-HIV drug, dapivirine (TMC120), will start: it is hoped that the ring, which will sit on the cervix and be renewed monthly, will overcome the adherence problems that have been the bane of HIV prevention trials using antiretroviral drugs. And of course the Truvada term will continue in VOICE and may represent, as ...
Estradiol is the generic resep kastengel ala fah umi yasmin alternative to Estrace Vaginal Cream Estradiol. This depakote side effects paranoia article is intended to provide baclofen 10 mg prix a broad overview of pharmacology and medications often used in either community or institutional tricor 933a pharmacy settings and is not intended as sole means towards determining diagnosis and/or treatment of an harga obat micardis telmisartan 80 mg individual International Online Pharmacy Online: Includes dose adjustments, warnings and precautions Estrace Vaginal Cream, which is also called Estradiol Vaginal Cream is a hormone replacement therapy medication. Atrophic urethritis It can also prevent bone loss (osteoporosis) in postmenopausal women. Forty-six of …. As I started to experience painful interceptor at age 52, doctor recommended to try Estrace cream and gave me estrace cream generic available physicians sample Conjugated estrogens vaginal cream (Premarin Vaginal Cream) is prescribed for ...
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Looking at U.S. women only, the difference between the progesterone gel and placebo groups could have occurred by chance, the FDA said.
A pH and redox dual-sensitive biodegradable polysaccharide, succinic acid-decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-l-Phe-l-Cys), was synthesized to load doxorubicin hydrochloride (DOX·HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and free of o
The most recent lead microbicide formulations, tenofovir (TFV) 1% gel and the dapivirine intravaginal ring (IVR), have been investigated as means to prevent primarily human immunodeficiency virus (HIV) acquisition. Recent clinical trials like CAPRISA 004 (clinical trial registration number NCT00441298) (1, 2), conducted by the Centre for the AIDS Programme of Research in South Africa, and the VOICE trial (Vaginal and Oral Interventions to Control the Epidemic; clinical trial registration number NCT00705679) (3) have investigated the effectiveness of TFV 1% gel to prevent HIV acquisition. CAPRISA 004 was a study comparing TFV 1% vaginal gel with a placebo when used before and after sex while the VOICE trial looked at daily use of an oral tablet (TFV or Truvada) or a vaginal gel (TFV 1% gel). CAPRISA 004 and the VOICE trial showed a reduction in herpes simplex virus 2 (HSV-2) acquisition that correlated with the use of TFV vaginal gel. This was surprising since TFV has modest anti-HSV activity in ...
Both my current urologist and my gynecologist are pressuring me to use Premarin vaginal cream to reduce UTIs. Since my mother, her sister and my sister all have had breast cancer, I have refused. Last month at my annual exam, my gynecologist insisted that the vaginal cream is not absorbed into the blood and will not promote breast cancer. More than three decades ago, there was evidence that vaginal estrogen cream (Premarin) could be absorbed rapidly and efficiently into the bloodstream (Journal of the American Medical Association, Dec. 14, 1979). More recent studies have confirmed that estrogen in vaginal creams or tablets (Vagifem) is readily absorbed into the body (Annals of Oncology, April 2006; Menopause, January 2009). There are concerns that vaginal exposure to estrogen might increase the risk of breast cancer in susceptible women. Metformin also is linked to reduced levels of vitamin B-12. Because this vitamin is crucial for nerve function, deficiency can contribute to numbness, tingling
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Vaginal cream: Insert one full applicator of vaginal cream into the vagina at bedtime for 7 consecutive nights. In addition, apply a thin layer of vaginal cream directly to the vulva and massage it in gently.. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.. It is very important that this medication be used exactly as prescribed. Finish all of the prescribed medication even if you start feeling better. If a dose is missed, apply it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.. Store this medication at room ...
In July 2010 at the International AIDS Conference in Vienna, the Centre for AIDS Programme of Research in South Africa (CAPRISA) announced ground-breaking results from the first clinical trial to show that a microbicide could prevent HIV infection. The findings demonstrated that women who used a vaginal gel containing an ARV called tenofovir were 39% less likely to be infected with HIV compared to those using a placebo gel. Among women who were most adherent, the tenofovir gel decreased the chances of HIV infection by more than 50%. Interestingly, tenofovir gel also reduced a womans risk of contracting herpes simplex virus type 2 (a permanent and incurable infection that can increase the risk of HIV infection) by more than half. The trials findings need to be confirmed. A large multinational trial among 5,000 African women in Zimbabwe, Uganda, and South Africa called VOICE is currently comparing ARV oral tablets (Truvada and tenofovir) to ARV vaginal gel (tenofovir) formulations and could ...
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Zidoval gel is for the treatment of bacterial vaginosis (commonly known as BV), it works against the bacteria most often responsible for bacterial vaginal infection. By applying Zidoval gel directly into the vagina, metronidazole can destroy the bacteria at the site of infection) wit are inn sure why liduvat vaginal get has been prescribed for you, ask your doctor. Your doctor may still want you to use Zidoval vaginal gel. Before using Zidoval gel, you may also wish to discuss with your doctor or pharmacist whether you may consume alcohol while using this product.
Relactagel Vaginal Gel 5ml x 7 is for the treatment and long term prevention of bacterial vaginosis. Dermatol is an all-natural spray that manages the micro-environment and assists in wound recovery Dermatol is a comprehensive one-step treatment with no need for other cleansers or ointments. ...
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Preliminary experience with oral and intravenous miconazole therapy in systemic candidiasis is promising, and the vaginal cream has produced higher cure rates than conventional nystatin vaginal tablets or amphotericin B vaginal cream, and there have been no published comparisons with other antifungal agents. SummaryMiconazole2, a synthetic imidazole derivative, is a new topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. It is particularly active against Candida spp., Trichophyton spp., Epidermophyton spp., Microsporum spp. and Pityrosporon orbiculare (Malassezia furfur), but also possesses some activity against Gram-positive bacteria.In vaginal candidiasis, miconazole vaginal cream has produced higher cure rates than conventional nystatin vaginal tablets or amphotericin B vaginal cream. There have been no published comparisons with nystatin vaginal cream or foaming vaginal tablets - the nystatin dosage form preferred by some
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A lower-dose estradiol vaginal cream than is currently available in the United States was an effective and well-tolerated treatment for dyspareunia in postmenopausal women, according to a recent phase 3, randomized, multicenter, double-blind, placebo-controlled trial.
Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. Its an oral hormone replacement, so it can have a lot of side effects, and its important to think through the benefits and potential hassles of this drug before using it. Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.
Introduction The aim was to evaluate the effect of maintenance treatment with progesterone gel compared to the gel base in delaying preterm birth among women with spontaneous preterm labor. Materials and Methods A randomized controlled trial in Sweden i...
Anderson DJ, Williams DL, Ballagh SA, Barnhart K, Creinin MD, Newman DR, Bowman FP, Politch JA, Duerr AC, Jamieson DJ. Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: Effects on markers of inflammation and innate immunity in cervicovaginal fluid. Am J Reprod Immunol 2009; 61: 121-129.. U.S. National Library of Medicine abstract ...
1. What was the aim of MTN-017?. MTN-017 was a Phase II study designed to determine whether a reformulated version of vaginal tenofovir gel is safe and acceptable as a potential rectal microbicide among HIV-negative men who have sex with men (MSM) and transgender women. Developed originally as a vaginal microbicide, the gel contains the antiretroviral (ARV) drug tenofovir, which is commonly used to treat people with HIV in combination with other ARVs. The tenofovir gel used in MTN-017 was formulated to contain less glycerin, a common additive found in many gel-like products, to make it more suitable for use in the rectum, and its use was tested daily and before and after sex, and compared to oral Truvada®. 2. Who conducted and funded the study?. MTN-017 was led by the Microbicide Trials Network (MTN), an HIV/AIDS clinical trials network established and funded by the National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the National Institute of Mental Health (NIMH) ...
Five participants discontinued gel use for a total of 1.04 women-years because of adverse events; four were due to genital findings, and one was due to congestive cardiac failure.. The overall pregnancy rate was 4.0 per 100 women-years: 3.2 per 100 women-years in the tenofovir arm and 4.7 per 100 women-years in the placebo arm (P = 0.183) (Table 3). At the time of analysis, there were six ongoing pregnancies, and 58.3% of the remaining 48 pregnancies had resulted in a full-term live birth. There were no significant differences in pregnancy outcomes by study arm, and there were no congenital anomalies. A total of 20.9 women-years of follow-up occurred while women were not using gel because of pregnancy.. Viral load and tenofovir resistance. The mean log HIV viral load at the time when HIV seroconversion was identified was 4.65 [interquartile range (IQR), 4.04 to 5.39] and 4.30 (IQR, 3.56 to 5.17) log copies per milliliter in the tenofovir gel arm (n = 38 HIV seroconverters) and placebo gel arm (n ...
Mansoor, L.E., Abdool Karim, Q., Werner, L., Madlala, B., Ngcobo, N., Cornman, D.H., Amico, K.R., Fisher, J., Fisher, W.A., MacQueen, K.M. and Abdool Karim, S.S. 2014. Impact of an adherence intervention on the effectiveness of tenofovir gel in the CAPRISA 004 trial. AIDS and behavior 18(5), 841-848 ...
The full results of MDP 301 are likely to be presented and published early in 2010, and the field is now awaiting the results of a South African study of a microbicide containing the antiretroviral drug tenofovir. That study, the CAPRISA 004 trial, is testing the use of tenofovir gel in women in KwaZulu-Natal, and the results are expected to be presented in the summer of 2010. CAPRISA 004 is a pilot study, and will be followed by results from the VOICE study, which is directly comparing a tenofovir gel with oral tenofovir pre-exposure prophylaxis (PrEP) in 4200 women at 10 sites in South Africa, Malawi, Uganda, Zambia and Zimbabwe. This sequence of studies will provide evidence about the potential for the use of antiretroviral drugs in microbicides, but even if they show that tenofovir gel works, the cost of conducting further large trials could make it difficult to raise funding in the current financial climate. A negative result in either of these studies could make funders reluctant to ...
The symptoms may circumvent: wasting of the urogenital tract, (driven by oestrogens scarcity), dyspareunea, vaginal dryness, itchiness periodic inflammatory disease of the urogenital tract, frequent urination, mild incontinence pre- and post-surgical GP of postclimacteric and opaquing smears products ...
Exact estimation of your effectiveness of your microbicide with respect to HIV elimination requires valid measurement of adherence to product work with. measures contract was small fairly. The Wisebag was found being acceptable as a storage box and the cell phone reminders generated were useful in supporting the dosing strategy. We recommend that the Wisebag be considered intended for larger level and lengthier testing in microbicide trials. Keywords: adherence electronic monitoring microbicides clinical trials HIV prevention BACKGROUND The effectiveness of HIV prevention interventions such as microbicides depends substantially on a participants ability to abide by the prescribed product and dosing instructions. Imperfect faith may reduce the test products effectiveness (1) and make study results difficult to interpret particularly if faith is not accurately monitored and assessed (2). Most adherence evaluation methods in microbicide trials rely on participant self-report of gel use i. ...
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ed protect against HIV in a large-scale clinical trial involving more than 2,600 women in Zimbabwe, Malawi, Uganda and South Africa, researchers who conducted the trial, known as ASPIRE, reported today.. ASPIRE, which was led by the National Institutes of Health (NIH)-funded Microbicide Trials Network (MTN), enrolled HIV-negative women ages 18 to 45. In Zimbabwe, the study was led by Dr Z. Mike Chirenje of UZCHS-CTU. 678 women took part in the study across three clinical research sites in Harare and Chitungwiza, Zimbabwe.. The study found the dapivirine ring reduced the risk of HIV infection by 27 percent overall - there were 27 percent fewer women who acquired HIV in the group assigned to use the dapivirine ring than in the group assigned to use a placebo ring containing no active drug.. The risk of HIV was reduced significantly more among the studys older participants, who also used the ring most consistently. Researchers initially found that women in the dapivirine group who were 25 and ...
Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches. Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Dont use these within 72 hours after a dose.
MTN-029/IPM 039 is a Phase I, open-label, multi-site study that is designed to assess the presence of dapivirine in breast milk when delivered via a silicone elastomer vaginal matrix ring containing dapivirine (25 mg) when used continuously for 14 days. The primary objective of this trial is to assess the pharmacokinetics (PK) of the dapivirine ring. The trial will also evaluate safety and tolerability, as well as adherence to the ring, when used for 14 consecutive days by lactating women. The study will enroll approximately 16 healthy, HIV-negative women ages 18 years and older, at least 6 weeks postpartum, who are lactating but not breastfeeding, at two U.S. sites. Each participant will wear the VR continuously for approximately 2 weeks. It is anticipated that this study will require approximately 12-18 months to conduct.. ...
Introduction Definition of the Prevention Area Microbicides are products formulated for individuals to apply topically (vaginally or rectally) to reduce their risk of HIV and possibly other sexually transmitted infections. At present, this approach is experimental, although several broad-spectrum microbicides have been clinically evaluated. Microbicides comprise a subset of approaches to pre-exposure prophylaxis (PrEP); oral approaches to PrEP are addressed in a separate entry. Epidemiological Justification for the Prevention Area In generalized epidemics, women are at a disproportionate risk of HIV infection for biological as well as social reasons. Although condoms are highly effective in preventing HIV transmission, it can be difficult for women to negotiate safer sex because the male partner often controls whether a condom is used. Microbicides were initially proposed as a woman-controlled or -initiated prevention method for vaginal application, something a woman could use to protect herself. The
For prevention of HIV, genital herpes and HPV. VivaGel® is being developed as a vaginal microbicide to offer safer sex by preventing transmission of genital herpes (HSV-2), HIV and other sexually transmitted infections (STIs) including human papillomavirus (HPV), the causative agent of cervical cancer.. There is an enormous global need for a vaginal microbicide offering protection of this kind. For example:. ...
Editors note: Find the latest COVID-19 news and guidance in Medscapes Coronavirus Resource Center.. Centers for Disease Control and Prevention (CDC) researchers report that more than 10,000 fully vaccinated Americans have experienced breakthrough COVID-19 through April 30, 2021. They note that the figures are likely an underestimate.. The 10,262 SARS-CoV-2 vaccine breakthrough infections were reported from January 1 through April 30 in 46 US states and territories. About one quarter of affected people, 27%, generic doxycycline no prescription were asymptomatic. Two percent, or 160 people, with breakthrough infections died, preliminary data reveal.. A total of 995 people were hospitalized, including 289 hospitalized for asymptomatic infection or for reasons unrelated to COVID-19, lead study author Meseret Birhane, MPH, and colleagues at the CDC note.. The study was published online May 25 in Morbidity and Mortality Weekly Report (MMWR).. The researchers recommend that all Americans aged 12 ...
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More than 28 years since the first cases of HIV/AIDS, there is still no cure or vaccine. The worst affected region is sub-Saharan Africa and, increasingly, it is young women who are bearing the brunt of the epidemic. Consequently, there is an urgent need for HIV prevention options for women in developing countries. Microbicides are topical products that can be used vaginally by women to impede sexual transmission of HIV and thus represent one of the most promising prevention strategies. Efficacy trials with early nonspecific microbicide gels have so far been unsuccessful, but the field has now switched its focus to products containing highly potent and highly specific antiretroviral drugs that are easier to use, and can be formulated in a variety of dosage forms to suit individual and regional preferences. However, these products have their own challenges, with a greater likelihood of absorption, and the potential for systemic toxicities or the development of resistance in infected individuals ...
Indications for Drugs ::. Premenstrual syndrome, Contraception, Menopausal HRT, Amenorrhoea, Recurrent miscarriage. Drug Dose ::. Oral Progestogen component of menopausal hormonal replacement therapy. Adult: 200 mg daily as a single daily dose at night for 12-14 days of each mth. Amenorrhoea Adult: 400 mg daily for 10 days. Dysfunctional uterine bleeding. Adult: 400 mg daily for 10 days. Vaginal Gel Dysfunctional uterine bleeding. Adult: 45 mg every other day from the 15th-25th day of the cycle. May increase dose to 90 mg in non-responders. Vaginal Gel Amenorrhoea. Adult: 45 mg every other day from the 15th-25th day of the cycle. May increase dose to 90 mg in non-responders.. Contraindication ::. Hypersensitivity; thrombophloebitis; cerebral apoplexy; severe hepatic impairment; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, as a diagnostic test for pregnancy; pregnancy. History or current high risk of arterial disease.. Drug Precautions ::. Discontinue medications if ...
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Dear SEE. I sent your question to Catholic physician Anthony Dardano and here is his response:. I will start by saying that you are certainly not alone with this problem. Having been a gynecologist some 44 years I have seen and treated thousands of patients with these same problems and frustrations. Therefore I answer you with the compassion and genuine concern these years of experience have given me. It is also important to state that although our lives, circumstances, etc., may change over the years, moral principles do not. Simply put, artificial birth control or sterilization can never be the answer. I certainly agree that following NFP in the peri menopausal era can be difficult due to the physiologic irregularity of the menstrual cycle during this time. There are however a few solutions which are morally acceptable. As a starter, the day flow starts is day 1. A progesterone tablet taken from day 16 thru 25 each cycle can over a period of a few months regularize a cycle enough to make NFP ...
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...July 9 2009 (BRONX NY) Scientists at Albert Einstein College of Me...For years scientists have been trying to develop a topical vaginal mi...Several microbicide gels have been assessed in clinical trials after p... Our goal was to develop assays that are predictive of safety before p...,New,lab,test,offers,better,prediction,of,HIV,microbicide,safety,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
There are many different preparations - pills, patches, gels, creams, vaginal creams and implants; pills containing different types of oestrogen and different types of progesterone, patches with and without a progesterone, and all of these available as cyclical or as continuous preparations. The starting point is whether the women has had a hysterectomy. If she has had a hysterectomy (and this applies to 20% of women), the decision is facilitated as there is no risk of developing uterine cancer from taking oestrogen alone. The oestrogen alone is given as a pill, a patch or, more rarely, an implant. If she has not had a hysterectomy, the question which influences the choice of preparation is whether she is at the menopause or a year postmenopausal. Women with a uterus who are going through the menopause need to take a preparation that continues to give them regular periods. This consists of daily oestrogen and usually 12 days of progestogen per month. Most women will get a period (withdrawal ...
Hormone Therapy - or what is called Hormone Therapy - has been around for the last 40 years or more. The problem is that what was called Hormone Replacement Therapy replaced human hormones with animal hormones and lab-created patentable chemicals that arent quite anything except lab-created patentable chemicals!. The Problem in the Industry:. Real human hormones cant be patented, so there isnt a huge profit in selling them like there is on something you have an exclusive on. Synthetic knock-offs are also cheaper to manufacture, are up to 100 times as powerful and have a longer shelf life.. The estrogenic product Premarin (which is now being promoted as a vaginal cream) has its name derived from its primary source - pregnant mare urine! They take the hormones from horse urine and package them for over a $Billion in sales to women all over the world. Some of those horse hormones are pretty close to human hormones, but none of them are human and some of them are 20 times as powerful. ...
The reaction mixture was stirred at ambient temperature for 1 hour under argon! VAGMYCIN VAGINAL CREAM: Amphotericin B : 50 mg activity/4 g! Ake enough at times! However, this may increase the risk of aspiration and obscure endoscopy visualization and you should consult your GI specialist beforehand! Ti-active-technologie clenbuterol legal in usa bang substanz und reduziert das vorhandensein von akuten. Tomam o remédio na sexta-feira e ficam garantidos por todo fim de semana! : {capsule: {dosage_sort: [500mg], patanjali rogan badam oil price overleaf dosages: {500mg: {quantities: [30], drug_id: 36284, name: 500mg, default_quantity: 30}}, singular: capsule, plural: capsules, display: capsule, default_dosage: 500mg}, dropper: {dosage_sort: [15ml-of-50mg-ml, 30ml-of-50mg-ml], dosages: {15ml-of-50mg-ml: {quantities: [1], drug_id: 35318, name: 15ml of 50mg/ml, default_quantity: 1}, 30ml-of-50mg-ml: {quantities: [1], drug_id: 35319, ...
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Crinone: Progesterone vaginal gel and vaginal tablets belong to the class of medications called progestins. These medications are used as part of an in-vitro fertilization (IVF) plan. They help to prepare the uterus lining so that a fertilized egg can be implanted (attached to the uterus) and to maintain a pregnancy once a fertilized egg has been implanted.
Its been quite the year (plus a month) for HIV prevention research. That glimmer of hope from the Thai vaccine trial. The striking effect of HIV-treatment as prevention. The positive results of the CAPRISA vaginal microbicide study, which were presented to rapturous applause this summer in Vienna.. And today, the iPrEx study is published, which shows that giving TDF/FTC to HIV-negative, high-risk men who have sex with men (MSM) reduces their risk of acquiring HIV by 44%. Its the first efficacy study of pre-exposure prophylaxis (PrEP) and will undoubtedly generate plenty of discussion.. For a detailed scientific analysis of the trial, two HIV prevention experts have already provided their commentary, Nelson Michael in NEJM and Raphy Landovitz in Journal Watch AIDS Clinical Care. I highly recommend both.. But every HIV specialist/Infectious Disease doctor will have thoughts on this important study, so in no particular order, here are mine:. ...
Call it an antiviral one-two punch. An HIV-fighting drug has been shown to be even more effective against genital herpes when its applied as a gel, new research shows. A study released this week by