Inflammatory eye disease (uveitis) can develop as a complication in children who have juvenile idiopathic arthritis (JIA). Children and adults who have JIA can develop cataracts, glaucoma, corneal degeneration (band keratopathy), or vision loss.. The incidence of eye disease is 2 to 34 out of 100 children who have JIA.footnote 1 It is most common in oligoarticular and RF-negative polyarticular forms of the disease. Eye disease associated with JIA often has no symptoms, although blurred vision may be an early sign. To prevent eye problems from progressing to the point that vision loss occurs, regular eye examinations by an ophthalmologist are very important for children who have JIA. Eye disease develops in about 30 out of 100 children who have oligoarticular JIA, particularly children who have a positive antinuclear antibody (ANA) test result.footnote 2. Early detection and treatment of inflammatory eye disease gives a child the best chance of a good outcome. Discuss the appropriate examination ...
BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid). Uveitis is the fifth most common cause of vision loss in high-income countries, accounting for 5% to 20% of legal blindness, with the highest incidence of disease in the working-age population.Corticosteroids are the mainstay of acute treatment for all anatomical subtypes of non-infectious uveitis and can be administered orally, topically with drops or ointments, by periocular (around the eye) or intravitreal (inside the eye) injection, or by surgical implantation. OBJECTIVES: To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (Issue 10, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations,
TY - JOUR. T1 - Challenges of childhood uveitis. AU - Abdwani, Reem. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Chronic uveitis is a rare, but potentially sight-threatening disease. The most common cause of chronic non-infectious uveitis is "idiopathic uveitis". However, some systemic diseases are associated with chronic uveitis in children and are discussed. Chronic uveitis merits special consideration in children. The unique differences in children are highlighted with special consideration for the diagnostic and therapeutic challenges encountered in their management. While corticosteroids remain the mainstay of initial therapy, a wide range of immunosuppressive agents have been used with variable success. The role of immonomodulatory agents such as methotrexate, cyclosproin and some of the new biologic agents such as etanecept, infliximab, adalimumab are reviewed. Successful outcomes may be achieved with appropriate immunosuppressant therapy when given early in the disease, although clinical trials ...
Alpharetta, Ga.-(BUSINESS WIRE)-Clearside Biomedical, Inc. today announced the eight-week ongoing observations in patients with non-infectious uveitis.. In the phase 1/2 clinical study, eight patients diagnosed with non-infectious uveitis at three U.S. study centers received a single suprachoroidal injection of a formulation of preservative-free triamcinolone acetonide injectable suspension using Clearsides proprietary microinjector. Of the eight patients treated in the trial, seven were experiencing macular edema at the time of treatment and were therefore evaluated for change in retinal thickness after the injection. All seven of these patients achieved clinically meaningful reduction in retinal thickness of at least 50 microns from their respective baselines at week 8. Five of these seven patients experienced a reduction in retinal thickness to below 310 microns, which represents the maximum retinal thickness for approximately 95% of the population with normal retinas. Regarding ...
Objectives This study aimed to investigate the levels of eleven oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis (IU) and systemically healthy individuals (H) with or without gingival inflammation. Materials and Methods Twenty-one patients with IU (n=21), and twenty-two systemically healthy individuals (n=22) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by ELISA. Bacteria gene copy numbers were determined by qPCR on plaque microbial DNA preparations. Results According to two-step cluster analysis, ANOVA and t-test: GCF, serum and salivary TNF-α, IL-17A, IL-17A/E; GCF and serum IL-6; salivary IL-17F and salivary, serum IL-17A/F levels were higher in the IU group than the H group (p,0.05). However, serum IL-10 and IL-17E levels were higher in the H group than the IU group (p,0.05). A. actinomycetemcomitans, F. nucleatum, S. oralis, A. naeslundi and V. ...
Purpose : Epigenetic modulation of histone and non-histone proteins plays a key role in regulating gene transcription. Histone acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). In recent years, HDAC inhibitors (HDACi) have emerged as potential therapeutics for reversing aberrant epigenetic changes, particularly as antitumor agents. At lower concentrations, HDACis have been shown to be anti-inflammatory and are thus gaining interest within the immunology field. Givinostat (ITF2357) is a pan-HDACi that is efficacious in refractory leukaemias. Little is known about the effects of Givinostat in an autoimmune setting. Therefore, we tested its effects in leukocytes from healthy controls and non-infectious uveitis patients. Methods : CD4+ T cells isolated from healthy controls (n=6) and uveitis patients (Sarcoidosis, Behçets and VKH; n=14) were cultured with anti CD3/CD28 and Givinostat (50-200nM). Post culture proliferation, cytokine production (IL-17, ...
Retrospective cohort study. VA (as logMAR equivalent) and other characteristics of patients with non-infectious uveitis managed at 5 academic ocular inflammation clinics were abstracted via standardized chart reviews. All visits using the same VA testing method as used at the initial visit (with correction or without correction) were binned into baseline, first 3 months, then 6 month intervals to 3 years, and 1 year intervals to 5 years. Visits within 30 days following surgical procedures were excluded. Linear mixed models evaluated the association of demographic and clinical characteristics with VA, and separately using inverse probability of censoring weights to correct for missing follow-up visits, the mean VA over time within different types of uveitis.. ...
Childhood uveitis is a collection of chronic rare inflammatory eye disorders which result in visual loss in at least one eye of one fifth of affected children. Despite the introduction of novel systemic immunochemotherapies, it remains a blinding disease. We have undertaken a systematic review of outcome measures used in interventional trials of children with, or at risk of uveitis, in order to investigate metric quality and heterogeneity, as possible barriers to the translation of clinical research into improved outcomes. Systematic review of trials registered within databases approved by the International Committee of Medical Journal Editors (ICMJE). Eligible trials for were those which involved participants aged under 18 years with or at risk of non-infectious uveitis. Data on date of study commencement, uveitis site, inclusion age criteria, and outcome measure characteristics including type, dimension and quality were extracted independently by two authors. Quality was determined using the
TY - JOUR. T1 - Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. AU - Watkins, Angela S.. AU - Kempen, John H.. AU - Choi, Dongseok. AU - Liesegang, Teresa L.. AU - Pujari, S. S.. AU - Newcomb, Craig. AU - Nussenblatt, Robert B.. AU - Rosenbaum, James T.. AU - Thorne, Jennifer. AU - Foster, C. Stephen. AU - Jabs, Douglas. AU - Levy-Clarke, Grace A.. AU - Suhler, Eric B.. AU - Smith, Justine R.. PY - 2010/3. Y1 - 2010/3. N2 - Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegeners granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics ...
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Chen, Xiangting, Chinnery, Holly R., Kezic, Jelena, Sidhu, Manpreet, Bernard, Claude, Forrester, John V. and McMenamin, Paul G. 2012, In vivo imaging of experimental autoimmune uveitis disease progression in Cx3cr1-GFP and CD11c-YFP mice, in ARVO 2012 : Proceedings of the 2012 Association for Research in Vision and Opthalmology Conference, ARVO, [Fort Lauderdale, Flo.], pp. 1-1. ...
|P|Equine recurrent uveitis (ERU) is the most common cause of blindness in horses and is believed to affect approximately 10% of the equine population. The exact cause of ERU remains unclear, although researchers have shown that recurrent bouts of inflammation involving activated T-cells (cells largely responsible for cell-mediated immunity) lead to ...
TY - JOUR. T1 - Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis. AU - Gilger, Brian C.. AU - Wilkie, David A.. AU - Clode, Allison B.. AU - McMullen, Richard J.. AU - Utter, Mary. AU - Komaromy, Andras M.. AU - Brooks, Dennis E.. AU - Salmon, Jacklin H.. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Objective: To determine the long-term efficacy, complications, and duration of effect of a cyclosporine (CsA) suprachoroidal implant (CSI) in horses with equine recurrent uveitis (ERU). Methods: Horses with ERU were treated with a 6-mm diameter, 25 mg, reservoir matrix CsA implant in the deep sclera adjacent to the suprachoroidal space. Horses with follow-up ,1 year were examined for frequency of uveitis episodes, complications, and vision at last recheck. Results: Data from 151 eyes of 133 horses from the USA and Europe that had CsA devices implanted for ERU were reviewed. Follow-up time ranged from 13 to 85 months after surgery, with ...
Objective. To describe efficacy and safety of infliximab in the treatment of childhood chronic uveitis during a long-term follow-up. Methods. Fifteen patients (median age 12 yrs, range 5-21 yrs) with chronic uveitis were enrolled. Before infliximab treatment, children had presented active uveitis despite treatment with MTX and/or CSA. All were also receiving oral prednisone (1-2 mg/kg/day) for at least 1 month. Infliximab (5 mg/kg) was administered at weeks 0, 2, 6 and then every 6-8 weeks. Later on, in patients enrolled in Florence the administration interval was progressively increased up to 10 weeks if uveitis did not flare, whilst in children from Padua the scheduled infusion rate was maintained every 6 weeks. Absence or recurrence rate of uveitis up to the last visit was recorded. Results. Median follow-up on treatment was 30 months (range 16-38 months), median number of infusions 22 (range 11-30). During the first year, 13/15 children achieved a complete remission over a median period of ...
TY - JOUR. T1 - Current evidence of anti-TNF alpha treatment efficacy in childhood chronic uveitis. T2 - a systematic review and meta-analysis approach comparing the different drugs. AU - Druce, K.. AU - Simonini, G.. AU - Cimaz, R.. AU - Macfarlane, G. J.. AU - Jones, G. T.. PY - 2015/8. Y1 - 2015/8. N2 - Childhood autoimmune chronic uveitis (ACU) is associated with serious long-term complications including blindness. In ACU refractory to treatment by DMARDs, some promising results have been obtained using anti-TNFα therapy, although results are equivocal. The aim of the current study was to summarise the existing evidence regarding the effectiveness of anti-TNFα agents in ACU. A systematic search of articles was conducted up to June 2012. Eligible studies investigated the efficacy of anti-TNFα therapy as the first biologic modifier immunosuppressant treatment for ACU, refractory to therapy with topical treatment and/or systemic treatment and at least one immunosuppressive treatment, among ...
This study investigated the efficacy of Tocilizumab (TCZ) in refractory uveitis associated to extraocular manifestations due to Behcets disease (BD).
Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
In addition to the known lipid-lowering effects, statins are now widely accepted to have anti-inflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.. ...
Objective and design A mathematical analysis of leukocytes accumulating in experimental autoimmune uveitis (EAU), using ordinary differential equations (ODEs) and incorporating a barrier to cell traffic. Materials and subjects Data from an analysis of the kinetics of cell accumulation within the eye during EAU. Methods We applied a well-established mathematical approach that uses ODEs to describe the behaviour of cells on both sides of the blood-retinal barrier and compared data from the mathematical model with experimental data from animals with EAU. Results The presence of the barrier is critical to the ability of the model to qualitatively reproduce the experimental data. However, barrier breakdown is not sufficient to produce a surge of cells into the eye, which depends also on asymmetry in the rates at which cells can penetrate the barrier. Antigen-presenting cell (APC) generation also plays a critical role and we can derive from the model the ratio for APC production under inflammatory ...
Mammography Debate - When to Start Screening - At what age is it recommended for a woman to start routine mammograms: A. 40 years old B. 50 years old C. Neither A or B D. Both A and B. Until last year, t... ...
This observational study will evaluate the safety, efficacy, characteristics of patients, characteristics of physicians and quality of life in patients who are
Objective Uveitis, a group of disorders characterised by intraocular inflammation, causes 10%-15% of total blindness in the developed world. The most sight-threatening forms of non-infectious uveitis are those affecting the posterior segment of the eye, collectively known as posterior segment-involving uveitis (PSIU). Numerous different clinical outcomes have been used in trials evaluating treatments for PSIU, but these may not represent patients and carers concerns. Therefore, the aims of this study were to understand the impact of PSIU on adult patients and carers lives and to explore what outcomes of treatment are important to them. ...
Journal Français dOphtalmologie - Vol. 41 - N° 3 - p. e91-e94 - Iconography : Bilateral uveitis associated with nivolumab therapy - EM|consulte
July 31,2008- Preclinical Data for a Topical Formulation of Voclosporin as a Potential Best-in-Class Treatment for Chronic Inflammatory Eye Diseases Presented at ARVO
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Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
He was so brave and soon became fed up with hospital visits. He was there every 2 weeks for examinations under anaesthetic to monitor his condition and to ensure no further damage was being done. After a few weeks it became apparent that Sams retina had detached and that the scar tissue was so great that it couldnt be repaired.. He was already blind in his left eye and we hadnt even realized. Two operations to repair the damage were unsuccessful. Nobody seemed to know what was wrong with him. Eventually this awful disease was given a name…Uveitis…inflammatory eye disease. After a couple more weeks we had more bad news, the disease was also in his right eye. We were worried sick. He needed further treatment and operations. His right eye was bad but steroid treatment and having the retina lasered down appeared to stabilize things. He still needed weekly checks.. In all this time he had been off school and missed most of yr 1 and some of yr 2. He was now also way behind his peers at school. ...
Uveitis is the term for inflammation inside the eye that can result from autoimmune diseases and infections. In nearly half the cases, the exact cause is not known. Acute and chronic inflammation can damage the retina and cause blindness. In the operating room and clinic we apply novel surgical and medical treatments. We have published studies on the use of a surgical implant that provides long-term release of medication inside the eye.. In the laboratory, we are analyzing the proteins in eye fluids from patients to identify the molecules and mechanisms that cause inflammation. We believe a "personalized proteome" is a key tool for developing highly individualized treatment for uveitis.. We have a special interest in inflammatory eye disease that develops in related family members. We are making significant effort to identify the gene and develop therapy for patients with ADNIV, an inherited form of uveitis.. Please contact us for a consultation or learn how to support our research ...
Inflammatory eye disease has blinded countless numbers of individuals during both ancient and modern times. And while most of such instances have occurred
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Endogenous uveitis is an important cause of blindness in young adults. The need for a comprehensive search for an aetiological antigen is stressed. A source of adjuvant, disturbance in host immunology and any associated ...
Background: In Adamantiades-Behçet disease, recurrent ocular inflammation may lead to loss of vision despite continuous immunosuppressive therapy (1-3). Preliminary evidence suggests that the anti-tumor necrosis factor (TNF) monoclonal antibody infliximab rapidly controls sight-threatening inflammation, a critical factor in avoiding chronic, irreversible retinal lesions (4, 5 ...
TY - JOUR. T1 - Primary uveal lymphoma with epibulbar extension masquerading as an intraocular inflammation. AU - Jusufbegovic, Denis. AU - Kim, Vivian. AU - Char, Devron H.. PY - 2015/2/1. Y1 - 2015/2/1. UR - http://www.scopus.com/inward/record.url?scp=84923060622&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84923060622&partnerID=8YFLogxK. U2 - 10.1016/j.jcjo.2014.11.018. DO - 10.1016/j.jcjo.2014.11.018. M3 - Letter. C2 - 25677298. AN - SCOPUS:84923060622. VL - 50. SP - e24-e26. JO - Canadian Journal of Ophthalmology. JF - Canadian Journal of Ophthalmology. SN - 0008-4182. IS - 1. ER - ...
Intravenous administration of the anti-interleukin-6 (IL-6) agent tocilizumab (Actemra, Genentech) is well-tolerated in patients with non-infectious uveitis involving the posterior segment and showing promising efficacy, according to interim outcomes reported by Quan Dong Nguyen, MD.
In this interview from AAO 2016, Dr. Debra A. Goldstein discusses the recent FDA approval of adalimumab for non-infectious uveitis.
Private biotech Eyevensys said today that it treated the 1st patient in a first-in-human phase I/II trial of its lead candidate, EYS606, for the treatment of non-infectious uveitis. The patient was treated in Paris at the Cochin Institute using the companys EyeCET technology. The EyeCET platform is an electro-transfection injection system that delivers non-viral plasmids to encode […]. ...
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Researchers comparing leading treatment approaches for patients with severe uveitis have discovered that systemic therapy with oral corticosteroids and immunosuppression can preserve or improve vision in the long term better ...
Disclosed is a method of treating ocular inflammation in a mammal in need of such treatment, including administering to the mammal an anti-inflammatory amount of rapamycin.
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TY - JOUR. T1 - Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. AU - Liou, Gregory I.. AU - Fei, Yijian. AU - Peachey, Neal S.. AU - Matragoon, Suraporn. AU - Wei, Shuanghong. AU - Blaner, William S.. AU - Wang, Youxiang. AU - Liu, Chengyu. AU - Gottesman, Max E.. AU - Ripps, Harris. PY - 1998/6/15. Y1 - 1998/6/15. N2 - Vision in all vertebrates is dependent on an exchange of retinoids between the retinal pigment epithelium and the visual photoreceptors. It has been proposed that the interphotoreceptor retinoid-binding protein (IRBP) is essential for this intercellular exchange, and that it serves to prevent the potentially cytotoxic effects of retinoids. Although its precise function in vivo has yet to be defined, the early expression of IRBP suggests that it may also be required for normal photoreceptor development. To further assess the biological role of IRBP, we generated transgenic mice with targeted disruption ...
TY - JOUR. T1 - Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response. AU - Mutimer, Helen P.. AU - Akatsuka, Yoshiki. AU - Manley, Thomas. AU - Chuang, Elaine L.. AU - Boeckh, Michael. AU - Harrington, Robert. AU - Jones, Thomas. AU - Riddell, Stanley R.. PY - 2002/9/1. Y1 - 2002/9/1. N2 - Cytomegalovirus (CMV) causes serious infection in individuals with deficient T cell immunity. In acquired immunodeficiency syndrome, the retina is a major site of progressive infection, despite the availability of therapy that targets CMV. The administration of highly active antiretroviral therapy to suppress human immunodeficiency virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inflammation termed "immune recovery uveitis" (IRU). To provide insight into the pathogenesis of IRU, the phenotype and specificity of intraocular T cells in a single patient were analyzed. The T cell infiltrate consisted ...
Title:Therapies in Development for Non-Infectious Uveitis. VOLUME: 15 ISSUE: 6. Author(s):M.A. Sadiq, A. Agarwal, M. Hassan, R. Afridi, S. Sarwar, M.K. Soliman, D.V. Do and Q.D. Nguyen. Affiliation:Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, 985540 Nebraska Medical Center, Omaha, NE 68198-5540, USA.. Keywords:Drug-delivery systems, immunomodulatory therapy, non-infectious, treatment, uveitis.. Abstract:Uveitis represents a spectrum of diseases characterized by ocular inflammation that leads to significant visual loss if left untreated. Adequate, long-term control of inflammation with minimal systemic and local adverse effects is the preferred strategy for treating patients with uveitis. Pharmacotherapy for uveitis consists mainly of corticosteroids in various formulations such as topical, local, intraocular and systemic. However, monotherapy with corticosteroids is often unacceptable due to serious adverse effects on various organ systems. There exist limitations ...
The goal of this proposal is to develop a clinical trials network capable of engaging in several clinical trials of the treatments of uveitis and its complicati...
TY - JOUR. T1 - Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis. T2 - a RCT. AU - Ramanan, Athimalaipet V. AU - Dick, Andrew D. AU - Jones, Ashley P. AU - Hughes, Dyfrig A. AU - McKay, Andrew. AU - Rosala-Hallas, Anna. AU - Williamson, Paula R. AU - Hardwick, Ben. AU - Hickey, Helen. AU - Rainford, Naomi. AU - Hickey, Graeme. AU - Kolamunnage-Dona, Ruwanthi. AU - Culeddu, Giovanna. AU - Plumpton, Catrin. AU - Wood, Eifiona. AU - Compeyrot-Lacassagne, Sandrine. AU - Woo, Patricia. AU - Edelsten, Clive. AU - Beresford, Michael W. PY - 2019/4/1. Y1 - 2019/4/1. N2 - BACKGROUND: Children with juvenile idiopathic arthritis (JIA) are at risk of uveitis. The role of adalimumab (Humira®; AbbVie Inc., Ludwigshafen, Germany) in the management of uveitis in children needs to be determined. OBJECTIVE: To compare the efficacy, safety and cost-effectiveness of adalimumab in combination with methotrexate (MTX) versus placebo with MTX alone, with ...
Do You Have Tuberculous Uveitis? Join friendly people sharing true stories in the I Have Tuberculous Uveitis group. Find support forums, advice and chat with groups who share this life experience. A Tuberculous Uveitis anonymous support group with in...