The synthesis of uteroglobin in rabbit lung was studied after the administration of glucocorticoids to intact adult animals as well as during the late stages of rabbit development. The synthesis of uteroglobin was compared with levels of translatable uteroglobin mRNA in the lung. Uteroglobin synthesis was determined both by incorporation of [25S]methionine into the protein by lung explants incubated in vitro and by radioimmunoassay measurements of uteroglobin concentration in lung. Lung poly(A)-containing mRNA, isolated by oligo(dT)-cellulose chromatography, was translated in cell-free systems and the activity of uteroglobin mRNA was determined after immunoprecipitation. Dexamethasone administration increased about 2-fold the synthesis of lung uteroglobin compared with the controls. The effect of cortisol was more moderate. Both glucocorticoids did not affect the degradation rate of lung uteroglobin, but produced increases in the translatable levels of uteroglobin mRNA parallel to those observed ...
Clara cells are non-mucous and non-ciliated secretory cells found in the primary bronchioles of the lungs, and were originally described by their namesake, Max Clara in 1937.. Clara cells are dome-shaped and have short microvilli. One of the main functions of Clara cells is to protect the bronchiolar epithelium. They do this by secreting a small variety of products, including Clara cell secretory protein (CCSP) and a component of the lung surfactant. They are also responsible for detoxifying harmful substances inhaled into the lungs. Clara cells accomplish this with cytochrome P450 enzymes found in their smooth endoplasmic reticulum. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.. CC10 (Clara cell secretory protein) ...
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Synonyms: Uteroglobin, Clara cell 17 kDa protein, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Scgb1a1, Ugb, Utg, UG, CC16, CCSP, PCB-BP. ...
Associations between environmental exposures and serum concentrations of Clara cell protein among elderly men in Oslo, Norway ...
Four DNaseI hypersensitive (HS) chromatin regions were found in the uteroglobin locus located at -3.7, -2.4, -0.1 and +4.1 kb with respect to the transcription start site of the gene. The three sites upstream of the gene are only detected in the hormonally stimulated endometrium and disappear after hormone withdrawal, whereas the site at +4.1 is also found in tissues that do not express uteroglobin. In the -2.4 HS region, which is strictly dependent on progesterone treatment, three DNaseI sites are clustered within a 240 bp DNA segment that contains 20 imperfect repeats of an octanucleotide motif. Upstream of the uteroglobin gene there are three regions containing binding sites for the glucocorticoid and the progesterone receptors, located at -3.7, -2.6/-2.7 and -2.4. The -2.4 region contains two binding sites for the hormone receptors flanking the central HS site. In footprinting experiments with naked DNA binding of the receptor also renders this site more susceptible towards digestion with DNaseI.
Clara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and inflammation. The purpose of the study was to investigate the role of elemental carbon ultrafine particles (EC-UFP)-induced oxidative stress on Clara cells and CC16 in a mouse model of allergic lung inflammation. Ovalbumin (OVA)-sensitized mice were exposed to EC-UFP (507 μg/m3 for 24 h) or filtered air immediately prior to allergen challenge and systemically treated with N-acetylcysteine (NAC) or vehicle prior and during EC-UFP inhalation. CC16 was measured up to one week after allergen challenge in bronchoalveolar lavage fluid (BALF) and in serum. The relative expression of CC16 and TNF-α mRNA were measured in lung homogenates. A morphometrical analysis of mucus hypersecretion and electron microscopy served to investigate goblet cell metaplasia and Clara cell morphological alterations. In non sensitized mice EC-UFP inhalation
The codes in CLARA mean:. BUILDING:LEVEL:1st INITIAL OF WARD NAME. So, for example, N3R means NORTH BUILDING (the main ward block); LEVEL 3: ROSELLA. ...
მისამართი: 77ა, მ. კოსტავას ქუჩა, თბილისი, 0171, საქართველო ტელ: 2 55 22 22; [email protected], [email protected] ...
MySingleFriend Member Profile: Max_4189 - Midlands-based Doctor Who seeks his Clara Oswald. Profession: Manager I have been described as a bit...
Smooth muscle cells in the walls of the bronchioles adjust their diameter and help to control the flow of air into the alveoli of the lungs. Your Lungs & Respiratory System a think about whats for lunch tomorrow b put your finger in your nose Its possible that some kids could say a or c or that others might even say - yikes! Lung volumes are measured clinically by a device known as a spirometer. The volume of air exchanged during deep breathing is known as vital capacity and ranges between 3 to 5 liters, depending on the lung capacity of the individual. In the middle airways, implicated stem cells include club cells and neuroepithelial cells that express club cell secretory protein . This quiz features the causes, symptoms, signs, and complications you need to know about this serious respiratory infection. Cancers may be treated by surgically removing the tumour, radiotherapy , chemotherapy or combinations thereof, or with the aim of symptom control . 31 Lung cancer screening is being ...
Complete information for SCGB2A2 gene (Protein Coding), Secretoglobin Family 2A Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Bird diseases can have a vast impact on humans, so understanding their immune systems can be a benefit for people. An important element in the immune system of
Sigma-Aldrich offers abstracts and full-text articles by [Venkataswarup Tiriveedhi, Natalia Tucker, John Herndon, Lijin Li, Mark Sturmoski, Matthew Ellis, Cynthia Ma, Michael Naughton, A Craig Lockhart, Feng Gao, Timothy Fleming, Peter Goedegebuure, Thalachallour Mohanakumar, William E Gillanders].
The season finale of Doctor Who, Hell Bent, concluded the three part story which began with the death of Clara Oswald in Face the Raven. It turned out that the ending of last weeks episode, Heaven Sent, contained some misdirection about where the finale was going. While the Doctor did return to Gallifrey, this was not at all what the episode was really about.. The Doctor returned to Gallifrey as a war hero, and used this return to save Clara. While the leaders on Gallifrey were concerned with the identity of the Hybrid, it turned out that the Doctor did not really know the answer. His priority was in saving Clara.. Face the Raven appeared to end with the Doctor allowing Clara to die as there was way to prevent her death. Now he was willing to break all the rules and risk the fracturing of time to save her. Clara was pulled out of time just before the moment of her death, in between heartbeats and lacking a pulse, not really living. She was informed of her condition by a general on Gallifrey: ...
Ana Clara P. Azevedo-Pouly is the author of this article in the Journal of Visualized Experiments: בידוד RNA מן העכבר לבלב: רקמות ribonuclease עשיר
Clara Moreno y Miramón preocupada por las niñas en desventaja social, huérfanos o abandonados, cedió sus bienes para establecer una casa y ayudarlos.
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Youve got most likely seen travel models with slide rooms and should have been inside of 1, but most likely do not know a lot about them. The folks over...
Zehra Ayhan, Donatella Duraccio, Birgül Özcan, Okan Eştürk, Serra Nalçabasmaz, Clara Silvestre, Sossio Cimmino, Gülsüm Erol, Murat Altan and Bengisu Toplu. B034 ...
Anti-mammaglobin antibodies, SCGB2A2 | Mammaglobin-A, human mammaglobin Q13296, mammaglobin antibody with no reactivity to no cross-reactivity to lipophilin A, lipophilin B (BU101), lipophilin C (lacryglobin, mammaglobin B), or uteroglobin mammaglobin,
The current cohort study in the canton of Zurich is investigating respiratory diseases in waste collectors. Therefore, a clinical history was taken and lung function tests and measurement of the Clara cell protein concentration were carried out. The first results show no elevation of the prevalence of asthma or other lung diseases in waste collectors. Compared with control subjects, waste collectors have a lower forced expiratory volume in the first second and a higher mean Clara cell protein concentration. The prevalence of cardiovascular risk factors such as smoking, obesity and arterial hypertension which are not caused by the occupation is high. Indeed, about 50% of all participants are hypertensive. ...
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The terminal bronchioles are a continuation of the bronchi and are the last divisions of the conducting airways. Gross Anatomy Terminal bronchioles are confusingly named, as they are not the final branches but rather the distal bronchioles th...
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Prenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand possible causes, an analysis was conducted of gene expression of a set of transcripts related to maternal recognition and establishment of rabbit pregnancy (uteroglobin, SCGB1A1; integrin 1, ITGA1; interferon-, IFNG; vascular endothelial growth factor, VEGF) in oviduct and uterine tissue at 16, 72 or 144 h post-ovulation and insemination. In the oviduct tissue, a significant decrease in the level of SCGB1A1 mRNA expression was observed from 144 h post-ovulation. In the case of ITGA1, the transcript abundance was initially lower, but mRNA expression increased significantly at 72 and 144 h post-ovulation. For IFNG, a huge decrease was observed ...
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H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC=C(C) ...
Foetal steroid binding protein (FSBP) is a normal constituent of adult human serum; in vivo it appears to influence the degree of steroid binding to albumin rather than acting primarily as a high affinity saturable binding protein. Serum levels are elevated in patients with parenchymal liver disease, hepatic malignancy and in those with non-metastatic breast cancer. That FSBP is protective against the development of breast carcinoma is however supported by a comparison of healthy women from racial groups at differing risk of this malignancy in which higher levels are found in those at lower risk. This hypothesis and the possible links between FSBP and primary hepatocellular carcinoma are further examined.. ...
In recent years, significant progress has been made in dissecting the genetic control of mammalian lung development. Many transcription factors, peptide growth factors and their receptors, as well as extracellular matrix components have been identified as important regulators of lung morphogenesis in reverse genetics approaches (Warburton et al. 2000; Groenman et al. 2004; Kumar and Ryan 2004). Chemical mutagenesis using the potent germline mutagen ENU represents a powerful means to complement these gene-driven approaches by phenotype-based screens in mice (De Angelis et al. 2000; Nolan et al. 2000; Kile et al. 2003). This report describes the positional cloning of the perinatal lethal, ENU-induced l7Rn64234SB allele and identifies a pivotal role for the previously hypothetical gene NM_026304 in Clara cell function during mouse lung development. The ENU-induced nonsense mutation truncated the carboxy-terminal 17 aa, rendering the l7Rn64234SB protein unstable. However, detection of residual ...
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Looking for online definition of Clara hematoxylin in the Medical Dictionary? Clara hematoxylin explanation free. What is Clara hematoxylin? Meaning of Clara hematoxylin medical term. What does Clara hematoxylin mean?
Polycyclic aromatic hydrocarbons and their quinines modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells", Deepak Gurbani, Santosh Kumar Bharti, Ashutosh Kumar, Alok k. Pandey, Godson R E E Ana, Ambrish Verma, Altaf Husain Khan, Devendra K. Patel, M K R Mudiam, Swatantra K. Jain, Raja Roy, Alok Dhawan, International Journal of Hygiene and Enviornmental Health(2013), http://dx.doi.org/10.1016/J.ijheh.2013.04. ...
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... (#3 in our series by Mark Rutherford) Copyright laws are changing all over the world. Be sure to check the copyright laws for your country before downloading or redistributing this or any other Project Gutenberg eBook. This header should be the first thing seen when viewing this Project Gutenberg file. Please do not remove it. Do not change or edit the header without written permission. Please read the "legal small print," and other information about the eBook and Project Gutenberg at the bottom of this file. Included is important information about your specific rights and restrictions in how the file may be used. You can also find out about how to make a donation to Project Gutenberg, and how to get involved. **Welcome To The World of Free Plain Vanilla Electronic Texts** **eBooks Readable By Both Humans and By Computers, Since 1971** *****These eBooks Were Prepared By Thousands of Volunteers!***** Title: Clara Hopgood Author: ...
Human SCGB1D1 Expression-Ready ORF Clone LS-N55657 is cloned in pLV-C-GFP containing tag (GFP, C-terminus). This construct is used in a Lentiviral expression system.
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Define bronchioalveolar carcinoma. bronchioalveolar carcinoma synonyms, bronchioalveolar carcinoma pronunciation, bronchioalveolar carcinoma translation, English dictionary definition of bronchioalveolar carcinoma. n. pl. car·ci·no·mas or car·ci·no·ma·ta An invasive malignant tumor derived from epithelial tissue that tends to metastasize to other areas of the body....
Figure 6: Hypothetical diagrams of the effect of Bakumondo-to. (a) After ligation of dioxins to the AhR, the receptor translocates from the cytosol to the nucleus, binds to DRE, and activates transcription of CYP1A1, mucin and other genes in bronchiolar Clara cells. Excess mucin production from Clara cells by dioxins is supposed to be responsible at least in part for respiratory symptoms of Yusho patients. (b) Active ingredients in Bakumondo-to would block activation of the AhR by competitive interference with the interaction between dioxins and the AhR, and inhibit transcription of mucin in Clara cells, leading to improvement of respiratory symptoms of Yusho patients ...
Shishova, E.Y., Stoll, J.M., Ersoy, B.A., Shrestha, S., Scapa, E.F., Li, Y., Niepel, M.W., Su, Y., Jelicks, L.A., Stahl, G.L., Glicksman, M., Gutierrez-Juarez, R., Cuny, G.D., Cohen, D.E. Stahl, G.L., Cuny, G.D., Cohen, D.E. Genetic Ablation or Chemical Inhibition of Phosphatidylcholine Transfer Protein Attenuates Diet-Induced Hepatic Glucose Production. Hepatology 2011, 54, 664 - 674.. Shishova, E.Y., Di Costanzo, L., Emig, F. A., Ash, D. E., Christianson, D.W. Probing the Specificity Determinants of Amino Acid Recognition by Arginase. Biochemistry 2009, 38, 121-131.. Wagle N., Xian, J., Shishova, E.Y., Wei, J., Glicksman, M.A., Cuny, G.D., Stein. R.L., Cohen. D.E. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal. Biochem. 2008, 383, 85-92.. Shishova E.Y., Yu F., Miller D.J., Faraldos J.A., Zhao Y., Coates R.M., Allemann R.K., Cane D.E., Christianson D.W. X-ray Crystallographic Studies of Substrate Binding to Aristolochene ...
... By David Proud * Publisher: Wiley * Number Of Pages: 460 * Publication Date: 2008-06-03 * ISBN-10 /