In this meta-analysis which included data gathered from 22 case-control studies, involving a total of 10,073 subjects, which investigated an association between vitamin or antioxidant intake (or serum level) and cervical neoplasm risk, results found that intakes of vitamin B12 (OR=0.35), vitamin C (OR=0.67), vitamin E (OR=0.56), and beta-carotene (OR=0.68) were found to be associated with a significantly reduced odds ratio of cervical neoplasm. The authors state, The findings of this meta-analysis indicate that overall, there were preventive effects of vitamin or antioxidant intake on cervical neoplasms in case-control studies.. Click Here to visit the journal website. Subscription required to view the full text of the article.. ...
Since FTO was recognized as the first m6A demethylase, the understanding of its biological function has been widely expanded. However, the role of FTO in cervical cancer tumorigenesis remains unclear. In this study, we first analyzed the expression of FTO in two independent human cancer datasets and evaluated the correlation between FTO level and cervical cancer progression. Using small hairpin RNA technology, we explored the function of FTO in cervical cancer cell line Hela and SiHa cells, respectively. We then determined the FTO targets by performing transcriptional profile with FTO deficient and competent Hela cells, and finally validated these targets with ribosome profiling and functional rescue experiments. Our data suggested that FTO was frequently overexpressed in human cervical cancer tissues and highly correlated with cervical cancer progression. FTO serves as an oncogenic regulator for cervical cancer cells proliferation and migration which is vastly depended on its demethylase activity.
A previous study showed E-cadherin expression was lost in some cervical cancer cell lines and tumours. This study was designed to clarify the significance of DNA methylation in silencing E-cadherin expression. We examined promoter methylation of E-cadherin in five cervical cancer cell lines and 20 cervical cancer tissues using methylation-specific PCR (MSP) and bisulphite DNA sequencing. The correlation of E-cadherin methylation and expression together with methyltransferase (DNMT1) were further studied. We found that hypermethylation of E-cadherin was involved in five cervical cancer cell lines and 40% (8/20) of cervical cancer tissues. E-cadherin protein was lost in 6/8 (75%) samples and 3/5 (60%) cell lines with promoter methylation. E-cadherin methylation was significantly correlated with increased DNMT1. Using an antisense DNMT1 oligo to transfect into SiHa HeLa C33A cell line, E-cadherin protein was re-expressed. We concluded that loss of E-cadherin expression was in part correlated with ...
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Analysis of primary cervical cancer tissue of patients with pelvic lymph node metastasis. Positive lymph nodes are an important prognostic factor in early-stage cervical cancer patients. Results provide insight into the molecular basis of pelvic lymph node metastasis in early cervical cancer ...
This publication, Comprehensive cervical cancer control: a guide to essential practice (C4GEP), gives a broad vision of what a comprehensive approach to cervical cancer prevention and control means. In particular, it outlines the complementary strategies for comprehensive cervical cancer prevention and control, and highlights the need for collaboration across programmes, organizations and partners. This new guide updates the 2006 edition and includes the recent promising developments in technologies and strategies that can address the gaps between the needs for and availability of services for cervical cancer prevention and control. ...
Our study aimed to provide health economic data to inform the development of the Hungarian cervical cancer prevention program. First, the national program needs to address the problem of the inefficiency of the current screening program [5, 6]. We have previously developed a health economic model to support this decision making process [7]. Furthermore, with the introduction of vaccination against cervical cancer, a new policy question was raised: whether to include the vaccination of adolescent girls in the cervical cancer prevention program. We aimed to analyze this question from a health economic perspective.. Our modeling results predicted that adding vaccination of adolescent girls with the AS04-adjuvanted human papillomavirus 16/18 vaccine to the national cervical cancer screening program would be cost-effective in Hungary. Although our results were quite robust to the uncertainty in the input parameters, larger changes in the most influential parameters could considerably change the ...
TY - JOUR. T1 - Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis. AU - Irwanto, Yahya. AU - Purwoto, Gatot. AU - Sutrisna, Bambang. AU - Rustamadji, Primariadewi. PY - 2012/10. Y1 - 2012/10. N2 - Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test ...
Julian Schink, MD, Chief, CTCA Division of Gynecologic Oncology, discusses recent findings that shed light on early-stage cervical cancer treatments in this Insider article.
Cervical cancer is a malignant tumor of the cervix, a part of the female reproductive tract. Recent studies have found the human papillomavirus (HPV) vaccine to be efficient in preventing high-grade cervical lesions. However, the exact effects and efficacy of the vaccine are not known. This study aims to evaluate the association between quadrivalent HPV vaccination and the risk of invasive cervical cancer.. This study included an open population of 1,672,983 girls and women aged 10-30 years. The researchers evaluated the association between HPV vaccination and the risk of invasive cervical cancer, keeping factors like follow-up and parental characteristics in check. The primary outcome of the study was the subsequent risk of invasive cervical cancer after HPV vaccination.. The included participants were evaluated for cervical cancer until they turned 31. The findings suggested that cervical cancer was reported in 19 women who had undergone quadrivalent HPV vaccination. In comparison, 438 women ...
Data & statistics on Cervical Cancer: Incidence of CIN 2/3 Detected Through Screening and Cervical Cancer Incidence Prior to Screening Incidence of CIN 2/3 Detected Through Screening and Cervical Cancer Incidence Prior to Screening. Rates are per 100,000 women undergoing routine cytologic screening for CIN 2/3, and per 100,000 women for cervical cancer. The peak incidence of invasive cervical cancer is observed approximately 25-30 years ..., Executive Summary Acronyms and Abbreviations Introduction 1.1 Background and purpose of this study 1.2 Methodology 1.3 Limitations of the study 1.4 Structure of the report Background 2.1 What is cervical cancer? 2.1.1 Risk factors and causes of cervical cancer 2.1.2 Development of cervical cancer 2.2 Prevention 2.2.1 Primary prevention 2.2.2 Secondary prevention 2.3 Diagnosis 2.3.1 Colposcopy 2.3.2 ..., Health burden of detected cervical intraepithelial neoplasia (CIN) 2 and 3, cervical cancer incidence, and mortality, before prophylactic vaccination and after
Data & statistics on Estimated Age-specific Cervical Cancer Mortality Rates in the Americas: Estimated Age-specific Cervical Cancer Mortality Rates in the Americas, 2000*, Calibration results of age-specific incidence and mortality of cervical cancer. The circles and bars represent the observed cancer incidence and mortality from the National Cancer Registry of Taiwan, respectively. The squares and hollow bars represent the predicted cancer incidence and mortality by the Markov model in which the current practice of cervical screening was applied from 30 years of age ..., Estimated age-specific cervical cancer death rate in an unscreened population (per 100,000)...
By Hui Xie-Zukauskas. While cervical cancer is one of the most common cancers in women, it is, thankfully, preventable. But do you know how to prevent cervical cancer? As the saying goes, what you dont know can hurt you. Here are five important approaches to cervical cancer prevention:. 1. Enhance awareness of cervical cancer.. Misconceptions and poor awareness about cervical cancer are common. Poor awareness may result in delayed detection and treatment due to lack of knowledge and motivation, which can promote poor survivorship. During cervical cancer awareness month, find a way to raise your awareness; e.g., read more information or watch videos on cervical cancer (at the CDC website), send this e-Card to loved ones or friends, and/or participate in a public service to spread the word.. 2. Vaccinate girls and boys.. More than 95 % of cervical cancer cases are closely associated with human papillomavirus (HPV) infection. Some types of HPV are also known to cause cancers of the anus, penis, ...
OBJECTIVE The purpose of the study was to investigate benign and malignant squamous cervical cells obtained by cervical swabs with regard to differentially expressed genes and gene expression profiling, in order to evaluate the biological behavior and clinical outcome of cervical malignancies. METHODS Cervical squamous cells from six women with high-risk human papillomavirus positive [HR-HPV(+)] cervical carcinoma and from six HPV-negative women with normal ectocervical cells were analyzed by cDNA array. RESULTS cDNA over-expression of several genes such as MET (c-met), Nm23-H1 (NME1), EGFR, KGFR, Nm23-H2 (NME2), ERBB2 (c-erbB-2), cyclin-dependent kinase inhibitor 4 (CDKN2A, p16INK4A), cytokeratin 8 (KRT8), KRAS (K-ras), FLT1, KGF (FGF7), BCL2-like 2 protein (BCL2L2), ERBB4, MYCN (N-myc), cyclin D1 (CCND1), KIT (c-kit), secreted phosphoprotein 1 (SPP1) and STAT1, was significant in cervical squamous cell carcinoma (CSCC). Gene expression was downregulated for 13 genes in CSCC, such as interleukin 1
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Objectives. Infection with high-risk human papillomavirus (HPV) is a critical factor associated withcarcinogenesis of the uterine cervix. HPV-16 is most frequently found, and is further subclassified into intratypicvariants based on the nucleotide sequences of the viral genes. Although certain HPV-16 variants are reported tobe associated with the progression of cervical lesions, these relationships remain controversial with differentresults for different populations. To provide data for another population, we investigated the prevalence ofHPV-16 and distributions of its intratypic variants among Mongolian women with cervical intraepithelialneoplasia (CIN) and invasive cervical cancer. Materials and Methods. We analyzed samples from 374 randomlyselected women who attended the National Cancer Center of Mongolia between January 2002 and July 2007,including 147 invasive cervical cancer patients, 127 CIN patients and 100 age-matched controls who werecytologically normal. HPV genotyping was initially
Previous studies have described the importance of DNA methylation in human cancers. Recently, an aberrant methylation pattern was found during the multistage pathogenesis of cervical cancer with an increasing trend to methylation with increasing pathological changes (7) . Promoter hypermethylation of various genes is a frequent epigenetic event in cervical carcinoma (6 , 7 , 15) .3 Epigenetic alterations have been successfully used as indicators of neoplastic serum DNA in patients with various carcinomas (16) . To date, no studies have been undertaken to investigate the methylation status of various genes in serum samples of cervical cancer patients. Recently, we identified five genes, namely CALCA, hTERT, MYOD1, PGR, and TIMP3, as being methylated significantly more frequently in cervical cancer tissue than in normal cervical tissue.3 In our study, all of the patients with methylated serum DNA revealed the same methylation pattern in the corresponding cervical cancer tissue, except one patient ...
article{9e26cd77-e33a-4061-b74b-6dd6a644862d, abstract = {BACKGROUND: Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority of women with positive cytology are also HPV DNA positive, screening strategies that use HPV DNA testing as the primary screening test may be more effective. METHODS: We used the database from the intervention arm (n = 6,257 women) of a population-based randomized trial of double screening with cytology and HPV DNA testing to evaluate the efficacy of 11 possible cervical screening strategies that are based on HPV DNA testing alone, cytology alone, and HPV DNA testing combined with cytology among women aged 32-38 years. The main outcome measures were sensitivity for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) within 6 months of enrollment or at colposcopy for women with a ...
Cervix cancer does not spread early. It spreads by way of the lymphatic system. Cervix cancer screening should be offered to all women over 25 years. There is limited evidence of benefit from screening in women aged over 60 years, though the likely yield of screening is low in women over age 60 since the incidence of high-grade cervical lesions declines after middle age. Cervix cancer is preceded by cervical intraepithelial neoplasia (CIN). Surgery for CIN is effective at reducing the risk of subsequent invasive carcinoma.
MONDAY, Feb. 3, 2020 (HealthDay News) -- Vaccination and screening could nearly wipe out cervical cancer in North America in the next 20 years and rid the world of the disease within the next century, researchers say.. In a new study, the researchers assessed the potential impacts of the World Health Organizations (WHO) draft strategy for cervical cancer elimination, which calls for 90% of girls to be vaccinated against human papillomavirus (HPV) by 2030.. HPV causes most cervical cancer cases.. The WHO plan also calls for 70% of women to be screened for cervical cancer once or twice in their lifetime, and for 90% of women with precancerous lesions or cervical cancer to receive appropriate treatment.. With HPV vaccination alone, cervical cancer cases would fall 89% within a century in 78 countries hardest-hit by the disease. Thats 60 million cases of cervical cancer prevented, according to the report.. With the added tests and treatment of precancerous lesions, cervical cancer cases would fall ...
BACKGROUND Lymphatic and hematologic metastases are rare in microinvasive cervical cancers (FIGO stage IA1), supporting a role for conservative treatment. Cervical conization followed by prolonged surveillance is an accepted treatment in patients with low-risk features and negative surgical margins. This option is particularly appealing for younger or nulliparous patients, in whom fertility may be highly desired. CASE We report a case of a 22-year-old, HIV-negative female with stage IA1 squamous cell cervical carcinoma who was found to have bilateral lymph node metastases in both pelvic and para-aortic distributions after electing to undergo hysterectomy. CONCLUSION Clinicians treating patients with microinvasive cervical cancer conservatively must be aware of the possibility of lymph node involvement and should consider radiological imaging to look for metastatic disease.
TY - JOUR. T1 - Issues in cervical cancer incidence and treatment in HIV. AU - Einstein, Mark H.. AU - Phaeton, Rebecca. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Purpose of review: Cervical disease burden continues to be especially high in HIV-infected women, even in the era of effective antiretroviral medications. This review discusses the multiple issues surrounding HIV-associated cervical cancer. Also, the unique treatment-related issues in HIV-associated cervical cancer are addressed. Recent findings: The incidence of invasive cervical cancer has remained stable in industrialized nations; however, it is only estimated in developing countries secondary to a relative lack of data collection and registries. Trends in HIV-associated cervical cancer have changed in the highly active antiretroviral therapy (HAART) era. Recent molecular pathways suggest that the natural progression of human papillomavirus infection, the causal agent in all cervical cancers, may be related to immune system dysfunction as ...
Question - my mom having 4th stage cervix carcinoma, suffering from diabetics, please help. Ask a Doctor about diagnosis, treatment and medication for Cervical cancer, Ask an Oncologist
According to the statistics for 2018, cervical cancer is the fourth most common cancer in women worldwide, with 569,847 patients yearly [1]. Patients with cervical cancer who have progressed to an inoperable stage or have experienced recurrence receive widely used anti-cancer chemotherapy and platinum-based chemotherapy [2]. Cisplatin is a platinum-based chemotherapeutic agent that is widely used for the treatment of malignant tumors, such as cervical cancer, lung cancer, and ovarian cancer [3]. Cisplatin mainly induces cross-linking at the N7-position of guanosine, which modifies DNA to induce apoptosis and kill cancer cells [4]. However, the use of cisplatin as a cancer treatment has been limited owing to its serious side effects involving the kidney or hearing impairment and the emergence of resistant cancer cells [5]. In order to overcome anti-cancer drug resistance, high-dose chemotherapy with increasing dose combination therapy that combines several chemotherapy agents, and concurrent ...
Worldwide, cervical cancer is the third most common type of cancer in women. It is much less common in the United States because of the routine use of Pap smears.. Cervical cancer starts in the cells on the surface of the cervix. There are two types of cells on the surface of the cervix, squamous and columnar. Most cervical cancers are from squamous cells.. Cervical cancer usually develops slowly. It starts as a precancerous condition called dysplasia. This condition can be detected by a Pap smear and is nearly 100% treatable. It can take years for dysplasia to develop into cervical cancer. Most women who are diagnosed with cervical cancer today have not had regular Pap smears, or they have not followed up on abnormal Pap smear results.. Almost all cervical cancers are caused by human papillomavirus (HPV). HPV is a common virus that is spread through skin-to-skin contact and also by sexual intercourse. There are many different types (strains) of HPV. Some strains lead to cervical cancer. Other ...
Conclusions: Magnetic resonance imaging stage IIB cervical cancers with negative PMI on physical examination should be surgically treated because of better survival rate than FIGO stage IIB cervical … Making an educated treatment decision begins with the stage, or progression, of the disease. In New Zealand, about 160 women develop cervical cancer each year - and about 50 die from it. If the biopsy shows abnormal cells on the surface of the cervix, you may need to have a cone biopsy or loop excision. In early, localized cervical cancer, five-year survival is 92 percent (SEER). Were trying to find your location, please click Allow if your browser is asking for your Objective: To investigate ethnic, socioeconomic, and urban/rural differences in stage at diagnosis and cervical cancer survival in New Zealand. Regular cervical screening is your best protection against developing cervical cancer. When you have either type of hysterectomy, you will also have a: Pelvic lymphadenectomy - removal of ...
References. 1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12-9. [ Links ] 2. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003;16:1-17. [ Links ] 3. Kuglik P, Kasikova K, Smetana J, Vallova V, Lastuvkova A, Moukova L, et al. Molecular cytogenetic analyses of hTERC (3q26) and MYC (8q24) genes amplifications in correlation with oncogenic human papilloma-virus infection in Czech patients with cervical intraepithelial neoplasia and cervical carcinomas. Neoplasma. 2015;62:130-9. [ Links ] 4. Sharma S, Mandal P, Sadhukhan T, Chowdhury RR, Mondal NR, Chakravarty B, et al. Bridging links between long noncoding RNA HOTAIR and HPV oncoprotein E7 in cervical cancer pathogenesis. Scientific Rep. 2015;5:11724. [ Links ] 5. Hu X-Y, Hou P-F, Li T-T, Quan H-Y, Li M-L, Lin T, et al. The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer. Int ...
Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. Recent findings have reported that Rab5a gene was involved in the progression of cancer. In the present study, we investigated the effect of Rab5a on cervical cancer invasion and metastasis and the molecular mechanism underlying the involvement of Rab5a. Rab5a expression was assessed by immunohistochemical analysis on a cervical cancer tissue microarray. RNA interference (RNAi) was performed to knock down the endogenous expression of Rab5a gene in HeLa and SiHa cells. Cell motility was evaluated using invasion assay and wound migration assay in vitro. The expression levels of integrin-associated molecules were detected by Western blot and immunofluorescence. We found that Rab5a was expressed at a high level in cervical cancer tissues. Silencing of Rab5a expression significantly decreased cancer cell
After the discovery of the role human papilloma virus (HPV) plays in cervical cancer development we have witnessed a change in the conception and interpretation of cervical cancer prevention processes. Primary prevention gained a new tool in the form of HPV vaccines. Secondary prevention, which is cervical intraepithelial neoplasia (CIN) detection, acquired a new diagnostic method - HPV test. Studies were initiated in order to determine the usefulness of HPV tests in cervical cancer prevention and screening. They revealed that DNA HPV test used in screening has higher sensitivity in CIN detection than PAP smear and that HPV negative patients are better and longer protected against developing cervical cancer in comparison to women with normal PAP smear results. HPV tests also possess a predictive value, which detects women more susceptible to developing cervical cancer in the future. PAP smear does not have a predictive value; it only detects a presence or absence of neoplasia at this particular ...
CIN2/3 have been increased for many years and mainly concern women aged 25-29 years. They are subsequent to a persistent HPV infection and are classically treated by conization. Recurrences occur in 7 to 18 % of cases, mainly after CIN3 management during the first 2 years of follow-up. Follow-up is crucial to detect and treat recurrence and to select high risk women who might develop cervical cancer. Colposcopy and cytology have been recommended since 1989 by French ANAES, but these methods have poor sensitivity and specificity. However, DNA HPV testing is more sensitive and has demonstrated a very high negative predictive value, while specificity and positive predictive value remain average. Other HPV markers like genotyping, viral load and integration begin to be used in screening but have not been investigated in CIN2/3 follow-up to assess the values of various HPV markers which predict CIN2/3 recurrence after conization. The primary objective is to describe HPV expression (genotyping, viral ...
A non profit organization initially led by the Cervical Cancer Prevention Network (CECAP) for the Cancer Institute Foundation (CIF), Bravehearts is dedicated to raising awareness on cervical cancer prevention. Bravehearts is currently supported by a growing number of women, including prominent personalities such as Abbygale Arenas-de Leon, who is the current president of the organization, Senator Loren Legarda, Pia Magalona, Ellen Tordesillas, Tessa Prieto-Valdes, Jeena Lopez, Maimai Davao, Joyette Jopson and Suzi Entrata.. The organization has held successful seminars and projects with the help of its partner organizations and companies. One of its more prominent events is the biking event, The Tour of Hope (TTOH). The tour was introduced in the Philippines in 2008 through the collaboration of GlaxoSmithKline Philippines and the UP Cancer Institute Foundations Cervical Cancer Prevention (CECAP) network program in strategic partnership with Team Davids Salon, the first all woman sports team in ...
The abnormal readings that predict cervical cancer are called cervical dysplasia, meaning that the cells of the cervix have been altered by the presence of HPV. These readings can be either LGSIL (low-grade squamous intraepithelial lesions) or HGSIL (high-grade squamous intraepithelial lesions). The higher the grade, the more abnormal the cells, and the closer to cancer it is. However, these LGSIL and HGSIL do not mean that cancer is present, only that abnormalities are present that may lead to cancer. When a pap test shows LGSIL or HGSIL, this means that HPV is definitely present, so there is no need to do a specific HPV test. (More on abnormal Pap testing in a later blog post ...
Treatment of cervical cancer has special steps not like any cancer nowadays, as its first and most important step is cervical cancer prevention , and then treatment of non- invasive cervical cancer which is called CIN treatment , and finally invasive cervical cancer treatment.. Follow up of these cases is not less important than treatment itself.. Cervical cancer prevention. There are multiple ways to prevent cervical cancer , the most important steps are screening by pap smear in all sexually active women and follow up that screening according to the new guide lines N.B : details n cervical cancer screening , also early detection and treatment of cervical infection with follow up of it can prevent cervical cancer , having protected sexual course also minimize the rate for sexual transmitted disease and so decrease risk for human papilloma virus infection , which is the main cause lead to cancer cervix .. Treatment of CIN( cervical intraepithial neoplasia , pre invasive cancer ...
Cervical cancer, with an annually increasing incidence rate, is becoming the leading cause of death among women in China. However, studies have shown that the early detection and accurate diagnosis of cervical cancer contribute to the long survival of cervical cancer patients. The machine learning method is a good substitute for manual diagnosis in the analysis of Pap smear cervical cell images, reflecting its effective and accurate classification. In the present study, a framework for cervical cancer diagnosis is presented based on a random forest (RF) classifier with ReliefF feature selection. Using preprocessing, segmentation, and feature extraction, 20 features were extracted. In the feature selection phase, 20 features were ranked according to weight using ReliefF. In the classification phase, the RF method was used as a classifier, and different dimensions of features were selected to train the classifier. To examine the efficacy of the proposed method, the Herlev data set collected at Herlev
Majority of the patients (58%) in our study were above 40 years old. Data from cancer registries in developing countries reported the same finding; 80%-90% of women with cervical cancer in the developing countries were above the age of 40 [12]. Eighty percent of women with cervical cancer in developing countries are diagnosed at advanced stages [13]. In our study, 47 patients (56.6%) presented with cervical cancer at stage III and IV, and these results were similar to other reports [14,15]. This might be attributed to the lack of screening services in our country and women tend to seek medical advice only when they have developed symptoms. In England, 23.8% of 382 women were diagnosed in stages III and IV [16] which contributes to the longer survival [17].. Many series reported pelvic failure rate of (20%-25%) and distant failure rate of (10%-25%) after concurrent chemoradiotherapy [18-22]. Our study reported local recurrence rate of 31.2%, and distant metastasis of 20.8%. The high local ...
Title:Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment. VOLUME: 15 ISSUE: 5. Author(s):J. Han and J. Guo. Affiliation:Department of Obstetrics and Gynecology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu, Daping, Yuzhong District, Chongqing 400042, P.R. China.. Keywords:Cervical cancer, pigment epithelium derived factor, angiogenesis, differentiation, apoptosis, immune, metastasis.. Abstract:Cervical cancer is the second leading gynecological malignancy threat to the health of women in the world. However, few improvements in the efficacy of treatments of cervical cancer have been reported for the recurrent and metastasis patterns. As an endogenous antitumor agent, pigment epithelium derived factor (PEDF) has attracted wide attention, and its sensitivity to estrogen suggests a special role in female tumors, including cervical cancer. This review aims to summarize recent findings, the role ...
Cervical cancer incidence and mortality have been reduced up to 80% in developed countries.1 Despite the absence of clinical trials, the relation between Pap-smear screening and reduction of cervical cancer incidence and mortality has been recognized.2. The decreased burden of disease has been attributed to screening coverage leading to increased effort for extending conventional cytology to all women worldwide. Although screening programs have been successful in developed nations, they have not fulfilled their objectives in the majority of developing countries.1,3 In Colombia, cervical cancer remains the first cause of cancer mortality and the second cause of cancer incidence among women.4. The lack of impact of conventional cytology in low and middle income countries has been linked to social and economic factors as well as deficiencies in program organization.5 Recent studies revealed that Pap-smear coverage does not correlate with trends of cervical cancer mortality in Latin America; ...
Cervical cancer incidence and mortality have been reduced up to 80% in developed countries.1 Despite the absence of clinical trials, the relation between Pap-smear screening and reduction of cervical cancer incidence and mortality has been recognized.2. The decreased burden of disease has been attributed to screening coverage leading to increased effort for extending conventional cytology to all women worldwide. Although screening programs have been successful in developed nations, they have not fulfilled their objectives in the majority of developing countries.1,3 In Colombia, cervical cancer remains the first cause of cancer mortality and the second cause of cancer incidence among women.4. The lack of impact of conventional cytology in low and middle income countries has been linked to social and economic factors as well as deficiencies in program organization.5 Recent studies revealed that Pap-smear coverage does not correlate with trends of cervical cancer mortality in Latin America; ...
If abnormal cells on the surface of the cervix spread deeper into the cervix, or to other tissues or organs, the disease is then called cervical cancer, or invasive cervical cancer. Cervical cancer occurs most often in women younger than the age of 50. It is different from cancer that begins in other parts of the uterus and requires different treatment. Most cervical cancers are squamous cell carcinomas and adenocarcinomas.. The mortality rates for cervical cancer have declined sharply as Pap screenings have become more prevalent. According to the American Cancer Society about 12,170 cases of invasive cervical cancer will be diagnosed in the U.S. during 2012. Some researchers estimate that noninvasive cervical cancer (also referred to as carcinoma in situ) is nearly four times more common than invasive cervical cancer.. ...
Title:Human Papillomavirus (HPV) Vaccines as an Option for Preventing Cervical Malignancies: (How) Effective and Safe?. VOLUME: 19 ISSUE: 8. Author(s):Lucija Tomljenovic, Jean Pierre Spinosa and Christopher A. Shaw. Affiliation:Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada.. Keywords:HPV vaccines, Gardasil, Cervarix, adverse reactions, vaccine efficacy, vaccine safety, conflict of interests, clinical trials, cervical cancers, safety profile. Abstract:We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective reporting of results from clinical trials (i.e., exclusion of vaccine efficacy figures related to study subgroups in ...
Background: The tumor-stroma ratio (TSR) represents the percentage of neoplastic cell components compared to the combined area of neoplastic cells and the surrounding tumor-induced stroma. A low TSR (predomination of stromal component) has been demonstrated to be an independent adverse prognostic factor in cancers of several organs. In cervical carcinoma patients, TSR has been evaluated in only one previous study with different histological types. The present study aimed to assess the prognostic value of TSR in early stage cervical cancer patients with adenocarcinoma histology only. Materials and Methods: Histological slides of patients with early stage (IB-IIA) cervical adenocarcinoma who underwent surgical treatment between January 2003 and December 2011 were reviewed. Patients who had received preoperative chemotherapy were excluded. TSR was categorized as low (,50%) and high (≥50%). Correlations between TSR and clinicopathological variables were evaluated. Prognostic values of TSR and ...
Extensive experimental and limited epidemiologic data suggest that adeno-associated viruses (AAV) can have antioncogenic activity and may be protective factors for the development of cervical cancer. To examine the association between AAV-2 IgG antibodies and cervical neoplasia in Spain and Colombia, we tested for AAV-2 antibodies using an ELISA assay for 109 women with invasive cervical cancer, 100 population-based controls age-matched to the invasive cases, 77 women with carcinoma in situ (CIN III) and 100 clinic-based controls age-matched to the CIN III cases. Human papillomavirus (HPV) DNA was detected in cervical exfoliated cells by polymerase chain reaction using HPV-L1 and GP5+/6+ consensus primers. The prevalence of AAV-2 antibody titers >100 was significantly lower in invasive cervical cancer cases than control participants. When comparing women with invasive cancer with controls or with CIN III cases, a pattern of decreasing cervical cancer risk with increasing AAV-2 titers was ...
Cervical cancer is the second most common malignancy in women worldwide and one of the leading causes of cancer mortality globally. In patients with invasive cervical cancer prognostic factors are of value for the choice of treatment, monitoring of treatment and follow-up. The most important clinical prognostic factors are stage, tumor volume, parametrial infiltration, vascular invasion, lymph node metastases, and distant metastases. An improved estimation of the prognosis of cervical cancer is desirable, especially in early cancer stages.. The aim of this research was to study possible associations between tumor markers, female sex steroids, smoking, S-phase fraction (SPF), and prognosis in invasive squamous cell cervical cancer (SCC). The study comprised 190 patients with SCC, stages IB-IV, admitted to the Department of Gynecologic Oncology at Norrland University Hospital in Umeå between September 1984 and October1990. Ten year mortality was estimated.. In study I, of a total of 103 patients, ...
The aim of the study was to calculate the proportion of women living with HIV among women with cervical cancer. The authors found that 5.8 percent of all new cervical cancer cases worldwide in 2018 were diagnosed in women with HIV infection. This corresponds to 33,000 cases per year, 85 percent of which occur in sub-Saharan Africa.. On the basis of the results, the team was also able to show that women with HIV are six times more likely to develop cervical cancer than women without HIV infection.. The association between cervical cancer and HIV is obvious, explains Prof. Dr. Dr. Andrea S. Winkler, Co-Head of the Center for Global Health. Cervical carcinomas are mostly caused by infections with human papillomavirus (HPV), which, like HIV, are sexually transmitted. Based on our results, one could assume that infection with HIV is a risk factor for infection with HPV. . South and East Africa are hardest hit. The regions of South and East Africa are hardest hit, with 63.8 percent (South Africa) ...
TY - JOUR. T1 - Adenocarcinoma of the Uterine Cervix. AU - Jerant, Anthony F. PY - 1997. Y1 - 1997. N2 - Background: Adenocarcinoma of the uterine cervix is an increasingly common cervical neoplasm that has received little attention in the primary care literature. The purpose of this paper is to describe an illustrative case that provides an excellent opportunity to review the symptoms, diagnostic pitfalls, treatment options, and prognosis of this important disease. Methods: Case report is described, along with results of a literature review using MEDLINE and pertinent references from retrieved articles. Results: The relative incidence of cervical adenocarcinoma has risen from 5 to 10 percent of all cervical neoplasms in the 1950s to 10 to 20 percent in recent series. Some studies have also reported an increasing absolute incidence linked to widespread oral contraceptive use. The diethylstilbestrol-associated clear-cell variant accounts for only 2 to 3 percent of cases. About 10 percent of ...
This January, Care to Care is proud to participate in National Cervical Health Awareness Month. Cervical cancer was once one of the most common causes of cancer death for women. However, the cervical cancer death rate has gone down by more than 50% over the last 40 years, mainly due to the increased use of the Pap test for screening and early detection. This amazing screening tool can find changes in the cervix before cancer ever develops, enabling doctors to treat pre-cancerous states. Unfortunately, not all women are getting screened. In 2012, 10% of US women ages 21-65 reported they had not been screened for cervical cancer in the last 5 years. According to the American Cancer Society (ACS), there will be an estimated 12,820 new cases of invasive cervical cancer diagnosed in 2017, with an estimated 4,210 deaths from the disease.. Another important fact that many may not know is that most cervical cancers are preventable! Nearly all cases of cervical cancers are caused by human papillomavirus ...
Quantitative human papillomavirus type 16 viral load and prognosis of cervical cancer treatment efficiency is considered in the article.
January marks Cervical Cancer Awareness Month and, in recognition of this, we are proud to present a range of some of the latest cervical cancer research published across BMCs oncology journals.. Despite being highly preventable through early screening methods and vaccination, cervical cancer remains the fourth most common cause of cancer among women worldwide.. Research into cervical cancer prevention, diagnostics, signaling pathways, and therapeutics is therefore crucial. The articles in this compilation have been curated by our cancer journal Editors and include the latest cervical cancer research from BMC in each of these four critical topics.. Cervical cancer prevention. ...
A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs. In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. All samples from women with cervical cancer, 61.2% of CIN3, 44.4% of CIN2 and 20.0% of CIN1 cases were scored positive for the GynTect methylation assay. In contrast, all CIN, irrespective of severity grade, and carcinomas were positive by both,
Human papillomaviruses (HPVs) are the primary causative agents for cervical cancer, and HPV oncoproteins E6 and E7 are known to be the main reason for the onset and maintenance of the malignancies. Therefore, inhibition of viral E6 and E7 oncoproteins expression represents a viable strategy to cervical cancer therapies. This study is to evaluate the antiviral effect of a novel N-Phenylbenzamide derivative, 3-(2-Chloropropyl amide)-4-methoxy-N-phenylbenzamide (L17), against HPV16 in vitro and identify its associated mechanism of action in cervical cancer cells. The cytotoxic effect of L17 was assessed by MTT assay. The mRNA and protein levels of E6 and E7 oncogenes were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and Western blot, respectively. p53 and Rb protein levels were also detected by Western blot. The effect of L17 on cell cycle was analyzed by flow cytometry. The cytotoxic effect of L17 was greater in cervical carcinoma cells than in normal cells. L17 significantly