Physical urticaria is a distinct subgroup of the urticaria that are induced by an exogenous physical stimulus rather than occurring spontaneously. There are seven subcategories that are recognized as independent diseases. Physical urticaria is known to be a painful, itchy and physically unappealing; which can recur for months to years of a persons life. There are seven sub-categories of physical urticaria: delayed pressure urticaria (DPU) cholinergic urticaria (ChU) cold urticaria (CU) solar urticaria (SU) Acute pressure urticaria (AU) chronic idiopathic urticaria (CIU) symptomatic dermatographism urticaria (SDU) (most common) Characterized by dermal edema (wheal) and erthema (flare) also known as hives. Hive lesions typically last less than 24 and are usually pruritic. Hives can appear on anywhere on the body and they may change shape, move around, disappear and reappear over short periods of time. Acute urticaria (short-term): can develop suddenly and will last less than 6 weeks. About 1 in 6 ...
Learn about XOLAIR, a treatment option for chronic idiopathic urticaria (CIU) patients who remain symptomatic despite H1 antihistamine treatment. INDICATIONS & IMPORTANT SAFETY INFORMATION INDICATIONS XOLAIR® (omalizumab) IS INDICATED FOR: Moderate to severe persistent asthma in patients 6 years of age and older who have a positive skin test or in vitro reactivity to a perennial aeroallergen and whose symptoms are inadequately controlled with inhaled corticosteroids. XOLAIR has been shown to decrease the incidence of asthma exacerbations in these patients. Chronic idiopathic urticaria in patients 12 years of age and older who remain symptomatic despite H1 antihistamine treatment. Limitations of Use: XOLAIR is not indicated for treatment of other allergic conditions or other forms of urticaria. XOLAIR is not indicated for the relief of acute bronchospasm or status asthmaticus. IMPORTANT SAFETY INFORMATION WARNING: Anaphylaxis Anaphylaxis presenting as bronchospasm, hypotension, syncope, urticaria,
Find information about managing chronic idiopathic urticaria (CIU), including disease symptoms and characteristics, the cycle of CIU, and patient stories. INDICATIONS & IMPORTANT SAFETY INFORMATION INDICATIONS XOLAIR® (omalizumab) IS INDICATED FOR: Moderate to severe persistent asthma in patients 6 years of age and older who have a positive skin test or in vitro reactivity to a perennial aeroallergen and whose symptoms are inadequately controlled with inhaled corticosteroids. XOLAIR has been shown to decrease the incidence of asthma exacerbations in these patients. Chronic idiopathic urticaria in patients 12 years of age and older who remain symptomatic despite H1 antihistamine treatment. Limitations of Use: XOLAIR is not indicated for treatment of other allergic conditions or other forms of urticaria. XOLAIR is not indicated for the relief of acute bronchospasm or status asthmaticus. IMPORTANT SAFETY INFORMATION WARNING: Anaphylaxis Anaphylaxis presenting as bronchospasm, hypotension, syncope,
definition of CIU, what does CIU mean?, meaning of CIU, Chronic Idiopathic Urticaria, CIU stands for Chronic Idiopathic Urticaria
TY - JOUR. T1 - A study of patients with chronic idiopathic urticaria from a medical center in northern Taiwan. AU - Chen, Jeng Feng. AU - Chung, Min Huey. AU - Liu, Ying Chun. AU - Wang, Wei Ming. PY - 2012/10/20. Y1 - 2012/10/20. N2 - Background: Chronic idiopathic urticaria (CIU) is a common dermatological disorder which significantly affects the quality of life of patients worldwide. This study investigates the demographic features, laboratory findings and the response to treatment of CIU patients prospectively in a medical center in northern Taiwan. Methods and Results: Thirtythree patients (15 females, 18 males, median age 32.79 years) with CIU were included according to the protocal approved for this study. A laboratory survey, including complete blood cells (CBC) with differential count, erythrocyte sedimentation rate (ESR), biochemistry panels, autoimmune profiles, thyroid function and multiple allergy simultaneous test (MAST) were conducted and analyzed before and after once daily ...
Looking to make friends with others who have autoimmune urticaria and share stories, symptoms, food for thought, etc. Anyone game?
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Introduction There is growing evidence that some cases of chronic idiopathic urticaria are associated with various autoimmune diseases such as thyroid autoimmunity. The association between chronic urticaria (CU) and thyroid disorders has been a subject of controversy. Some reports link CU with hyperthyroidism or hypothyroidism. The frequency of thyroid antibodies in patients with chronic idiopathic urticaria reported in 2009 was 30%, which is higher than that previously reported. Objective This is a case-control study that aimed to detect the presence of markers of thyroid autoimmunity (thyroid autoantibodies with or without underlying abnormal thyroid functions) among a cohort of autologous serum skin test (ASST)-positive patients with CU in comparison with ASST-negative CU patients as well as with healthy controls, and correlating it to the severity of urticaria symptoms. Patients and methods This study was carried out on 80 CU patients attending the Allergy and Immunology Clinic of Ain Shams ...
Objective To investigate the expression of C3, C4 and IgG in peripheral blood of patients with chronic urticaria(CU) and its correlationship with CU patients severity. Methods The expression of C3, C4 and IgG was measured by Immune Turbidimetry in 19 patients with acute urticaria(AU), 146 patients with CU and 20 normal controls. The severity of 165 patients with uricaria was evaluated by Urticaria Activity Score (UAS). Results There were no statistically difference in the expression of C3, C4 and IgG between AU and CU patients(P0.05), between male and female CU patients respectively(P0.05). The expression of IgG was higher than normal control(IgG17g/L) in 32 CU patients, and showed negative correlation with the expression of C3 and C4(P0.05). UAS was poor relation to the expression of C3, C4 and IgG in urticaria patients peripheral blood, but was negative correlation to the levels of C3, C4 in CU patients whose expression of IgG was higher than normal control(P0.05). Conclusion The expression of C3,
OMALIZUMAB TRIAL. The results of the first of three phase III clinical trials of the effects of omalizumab in patients with chronic idiopathic urticaria were reported online in the New England Journal of Medicine this week.. Urticaria (hives) occurs when mast cells in the skin are triggered to release histamine and other inflammatory mediators stored in cytoplasmic granules (degranulation). In acute urticaria due to allergic reactions, degranulation is triggered when allergen is bound by IgE antibodies attached to FcεRI receptors on the mast cell surface. However, chronic urticaria is not IgE mediated and the mechanism by which mast cells are triggered to degranulate and release histamine is not known.. Omalizumab is a recombinant humanized monoclonal antibody which binds rapidly to circulating IgE, inhibiting its attachment to FcεRI receptors on basophils and mast cells. Expression of FcεRI receptors in basophils is downregulated within 2 weeks, and within 8 weeks there is reduced ...
My wife has been experiencing an outbreak of chronic hives for almost 2 years. It started after she broke some bones in her foot and in using crutches she got a pressure hive outbreak. We have tried co...
TY - JOUR. T1 - Genetic polymorphisms in aspirin-intolerant chronic urticaria. AU - Park, Hae Sim. AU - Kim, Seung Hyun. AU - Hur, Gyu Young. AU - Ye, Young Min. AU - Kim, Sangha. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Background: Aspirin (acetylsalicylic acid, ASA)-intolerant urticaria with angioedema (AIU), a major type of aspirin-related hypersensitivity in urticaria, can be classified into two groups, acute ASA-intolerant urticaria (AIAU) and chronic ASA-intolerant urticaria (AICU), according to the duration of the urticaria. The pathogenic mechanism of AICU is not well understood. Methods/Data base: We present here a review of the recent findings from AICU molecular genetic studies. Results: A previous study on human leukocyte antigen (HLA) genotypes suggested that the HLA alleles DRB1*1302 and DQB1*0609 may be genetic markers for ASA-induced urticaria/angioedema for both AIAU and AICU, and that they were significantly associated with the prevalence of serum-specific immunoglobulin E (IgE) to ...
The UAS7 is the sum of the daily urticarial activity scores over 7 days and ranges from 0 to 42. The daily urticarial activity score is the average of the morning and evening urticarial activity scores and ranges from 0 to 6. The urticarial activity score is the sum of ratings on a scale of 0 to 3 (0=none to 3=intense/severe) for (1) the number of wheals (hives) and (2) itch intensity over the previous 12 hours, ranges from 0 to 6, and is measured twice daily (morning and evening). The Baseline score is the sum of the daily urticarial activity scores over the 7 days prior to the first treatment. A higher urticarial activity score indicates more urticaria activity. A negative change score indicates improvement ...
Chronic urticaria can be defined as the occurrence of widespread daily or almost daily wheals for at least 6 weeks, which may be accompanied by angioedema. While the wheals are transient, the resolution of angioedema is slower than wheals and could take up to 72 hours. The natural course of chronic urticaria is self-limited, with spontaneous remissions and occasional relapses. The investigators calculated a 0.6% (95% CI(Confidence Interval): 0.4-0.8) prevalence in a population study. It has a great impact on patients quality of life. In a recent national survey on patients attending Allergy Department, chronic urticaria was the disease with greater impact on mental quality of life out of all allergic diseases.. In spite of the high morbidity of this disease and the impact in quality of life, there is no available treatment. Last guidelines recommend initiating treatment with antihistamine and if there is no response to increase the dose off-label up to four-fold; systemic corticosteroids are ...
Adrenergic: Reaction to adrenaline / noradrenaline (extremely rare) Related conditions of Urticaria: Angioedema is related to urticaria. In angioedema, the swelling occurs in a lower layer of the dermis than it does in urticaria. This swelling can occur around the mouth, in the throat, in the abdomen, or in other locations. Urticaria and angioedema sometimes occur together in response to an allergen and is a concern in severe cases as angioedema of the throat can be fatal.. Treatment & Management: Urticarias can be very difficult to treat. Most treatment plans for urticaria involve being aware of ones triggers, but this can be difficult since there are several different forms of urticaria and people often exhibit more than one type. Also, since symptoms are often idiopathic there might not be any clear trigger. If ones triggers can be identified then outbreaks can often be managed by limiting ones exposure to these situations.. While the disease is obviously physiological in origin, ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Omalizumab efficacy in cases of chronic spontaneous urticaria is not explained by the inhibition of sera activity in effector cells
Urticaria cholinergic is another type of the Urticaria that is caused by a certain physical stimulus of some or of the other class. It is classified like physical urticaria, meaning that is caused by a physical stimulus of a certain class. The physical stimulus could be indicated as heat although the real cause is defined as sweating. The study of the activity of the cell of the mast includes Urticaria generally cholinergic because most of the cases of Urticaria cholinergic looks like to critically imply the cells of the mast. The main mediator is the histamina of the serum, that rises in the concentration when an induced test exercise is introduced. This treatment also implies quimiotácticos factors eosinophil and of the neutrophil as well as it tryptase. The levels of the alpha 1-antichymotrypsin diminish, and the use of danazol gives rise to the improvement in the eruption. Due to these results, some have discussed in please proteases like a cause of the histamina that was sent. The skin ...
Chronic urticaria (CU) or chronic spontaneous urticaria is defined by the presence of urticaria (hives) on most days of the week, for a duration of longer than six weeks. Associated angioedema occurs in about 40 percent of patients.Standard managemen
Omalizumab is a monoclonal anti-IgE antibody currently used in the treatment of chronic spontaneous urticaria (CSU) as a third-line option in cases refractory to treatment with the licensed dose of the first-line treatment or up to 4 times that dose. The introduction of omalizumab into the therapeutic arsenal for CSU brought about a real revolution in the management of this condition. However, the dose recommended in the Summary of Product Characteristics-based on the results of pivotal studies carried out as part of the approval process-is 300 mg/mo for a period of up to 6 months. In the present issue, the Catalan-Balearic working group presents a treatment algorithm to guide the use of omalizumab in the management of CSU. They discuss the various aspects of management related to the rational and evidence-based use of this drug, including candidate population, monitoring tools (Urticaria Activity Score 7 [UAS7] and Urticarial Control Test [UCT]), starting dose and dose adjustment as well as the ...
Stull, D., Mcbride, D., Georgiou, P., Zuberbier, T., Grattan, C., & Balp, M. M. (2014). Measuring patient severity in chronic spontaneous/idiopathic urticaria (CSU/CIU) as categorical health states: efficient and informative?. In [69], pp. 317-317. .. ...
A randomized, double blind, multicenter, parallel group, placebo and active controlled clinical trial was conducted in children aged 2-11 year suffering from CSU. Patients were randomly allocated to one of the treatment groups: Rupatadine 1mg/mL, Desloratadine 0.5mg/ml, or placebo oral solutions. Dosing was done according to patients weight (2.5 ml , 10 Kg - 25 Kg or 5 ml , 25 Kg). Patients received the study medication during 6 weeks (42 days) and symptoms were scored daily in the patient diary. There was a safety follow up period of 6 weeks (42 days) after the end of treatment. The primary efficacy variable was the change in the 7-day cumulative children adapted Urticaria Activity Score (UAS7) over the treatment period. Other efficacy assessments included the mean number of wheals (MNW) score, mean pruritus (MPS) score and Children Dermatology Life Quality Index (CDLQI). Adverse events were recorded through the study (84 days). ...
Certain people can develop recurrent hives from sunlight, cold, pressure, vibration or exercise. These are called the physical urticarias. If hives develop from scratching or firmly rubbing the skin it is called dermatographism. It is the most common of the physical urticarias and it affects about 5 percent of the population. It doesnt always itch. This condition sometimes also occurs along with other forms of hives.. Some people react to anything that makes them hot or sweaty with hives. This can be sunlight, exercise, hot baths, blushing or anger. These are tiny intensely itchy hives with a big red blotch around them and are called cholinergic urticarial.. Pressure urticaria shows up as a deep welt in an area of prolonged pressure. Occasional people react to the cold. Even more rare is a reaction to sunlight.. Occasionally, a person will continue to have hives for many years. These hives, called chronic urticaria, can be one of the most frustrating problems dermatologists see in their ...
Chronic urticaria is defined as a skin disease with central induration (wheal) and erythema formation around it (flare) that appears at least twice a week and remains at least for 6 weeks continually. The incidence of urticaria in children is about 0.1-3%. Most cases of chronic urticaria occur in children between 6-11 years. ...
Basel, March 6, 2018 - A new global guideline on chronic urticaria (CU) recommends Xolair® (omalizumab), indicated as add-on therapy for the treatment of chronic spontaneous urticaria (CSU), for patients who are not responding to antihistamines[1],[2]. Xolair is the only licensed treatment option for CSU, a type of CU, for patients unresponsive to antihistamines[1]. CU, including CSU, is a severe disease that causes itchy, persistent hives and painful swelling. The guideline recommends Xolair as the only treatment qualified with very good efficacy and very good safety in CSU[2]. The guideline was endorsed by key dermatologic and allergy professional medical societies around the world.. Marcus Maurer, MD, Professor of Dermatology and Allergy and Director of Research at the Department of Dermatology and Allergy, Allergie-Centrum-Charité of the Charité - Universitätsmedizin in Berlin, Germany said: "I highly welcome the new guideline, as it brings greater public awareness of the disease and ...
Doctors help recognize, prevent, and treat allergies: Dr. Kanter on giant urticaria: There are at least five important systemic mast cell diseases (mastocytosis) and even more causes of chronic urticaria (of which some mastocytosis diseases are only one cause). Often, no cause is ever found for chronic urticaria. A hematologist will probably treat mast cell disease -- perhaps in a research study -- while a dermatologist will manage chronic urticaria. Good luck; stay proactive.
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The purpose of this study is to assess healthcare resource utilization (HCRU) among urticaria patients prior to and after omalizumab initiation in a real-world
Table 54-14 Causes of Urticaria and Angioedema I. Primary cutaneous disorders A. Acute and chronic urticariaa B. Physical urticaria 1. Dermatographism 2. Solar urticariab 3. Cold urticariab 4. Cholinergic urticariab C. Angioedema (hereditary and acquired)b II. Systemic diseases A. Urticarial vasculitis B. Hepatitis B or C infection C. Serum sickness D. Angioedema (hereditary and acquired) a A small minority develop anaphylaxis. b Also systemic. The common physical urticarias include dermographism, solar urticaria, cold urticaria, and cholinergic urticaria. ...
However in many cases, there is no known trigger, leading to a diagnosis of idiopathic chronic urticarial.. A number of studies have indicated that H pylori infection may play a role in the development of urticaria / hives because of the damage caused to the stomach by the infection.. The inflammatory response in the stomach and small intestine (gastritis & duodenitis, respectively) that is caused by H pylori infection may lead to an increase in permeability of the delicate gut lining.. In other words, tiny gaps and holes appear in the stomach lining, which allow larger, undigested particles of food, bacterial antigens or chemicals into the blood. Once there, the immune system mounts a response, leading to inflammation on the skin.. Several other mechanisms involving the immune system may also contribute to the development of chronic urticaria in H pylori-infected people.. Some studies - I have seen the data from 16 studies in total - have shown partial or complete remission in urticaria in ...
Summary Transient urticaria was seen in five of 75 cases (six per cent) of malaria in a general hospital in China. The eruption appeared with the rise in temperature and disappeared with defervescence. With one exception none of the individuals gave a history of previous urticaria or other allergic disorder. Subsequently another case was seen in a civilian who had been a marine. He had repeated bouts of malaria with or without urticaria, and repeated bouts of urticaria apparently independent of malaria. He was also asthmatic and skin tests for several allergens were positive. A review of the world literature indicated that urticaria in malaria may occur in acute or chronic malaria. It may occur in malaria of any parasitic type. It may be the sole symptom or it may occur together with other symptoms. It may occur once or recur regularly or irregularly.
Treatment of Urticaria in Ayurveda is a very old science. Urticaria is a skin disease and could be treated by implication of Ayurveda and Medical Astrology. Urticaria treatment in Ayurveda involves Panchakarma therapy. Ayurvedic Treatment of Urticaria, Urticaria Treatment in Ayurveda
Treatment of Urticaria in Ayurveda is a very old science. Urticaria is a skin disease and could be treated by implication of Ayurveda and Medical Astrology. Urticaria treatment in Ayurveda involves Panchakarma therapy. Ayurvedic Treatment of Urticaria, Urticaria Treatment in Ayurveda
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Omalizumab, a humanized monoclonal anti-IgE antibody has the potential to alter allergen processing. Recently, it has been postulated the assessment of PHA-stimulated adenosine triphosphate (ATP) activity as maker of CD4+ T cells activity in peripheral blood cells. We present the case report of a 35-year-old woman with a history of chronic idiopathic urticaria and angioedema of 8 years of development with poor response to treatment. The patient was partially controlled with cyclosporine at doses of 100 mg/12 h. However, she was still developing hives daily. Finally treatment with omalizumab was started at dose of 300 mg every 2 weeks. The patient experienced a decrease in urticarial lesions 2 days after starting therapy. We also evaluated the effects of omalizumab therapy on the activity of peripheral blood CD4+ T cells from the patient, in order to determine the potential modification of anti-IgE therapy on the process of antigen presentation-recognition. Activity of CD4+ cells by ATP release was
Chronic idiopathic urticaria is a rare but significantly life-altering skin disease. Recent developments in immunology have promoted our understanding of its autoimmune pathology, but treatment options have not yet developed at the same pace. When an
Lifestyle changes include switching to an all fruit diet for five days, maintaining a balanced food diet of nuts, seeds, fruits, grains and vegetables and avoiding foods like coffee, tea, alcohol, and foods that are hard to digest.. Epson salts baths in hot water are claimed to be the most effect way to relieve outbreaks of urticaria or angioedema. The patient should soak in a hot bath treated with a cup of Epson salts for 20 minutes or more at least three times a week. Do not use soap as it may introduce harmful chemicals and prevent the positive effects and results of the Epson salts.. There is also a chemical free technique or Organic technique that is proving quite helpful for treating chronic urticaria. The theory is by wearing and using clothes and other items like sheets and bath towels that have not been exposed to laundry detergent chemicals, toxicity levels are greatly reduced in the body, and the immune system is boosted.. After about four to six weeks, urticaria and angioedema could ...
Cholinergic urticaria (CU) is a type of physical urticaria (or hives) that appears when a person is sweating. CU typically presents with a number of small, short-lasting hives but may also involve cutaneous inflammation (wheals) and pain which develops usually in response to exercise, bathing, staying in a heated environment, or emotional stress. Although the symptoms subside rapidly, commonly within 1 hour, CU may significantly impair quality of life, especially in relation to sporting activities. Though overall research is limited, various studies indicate that CU is relatively common across populations with prevalence rates reportedly ranging from 5% to 20% (depending on locale, race, and age). The condition is more common in young adults, and prevalence appears to peak in adults aged 26-28 (up to 20%). The vast majority of cases are reported to be mild, and proportionally few individuals seek medical attention regarding the condition. Sweat hypersensitivity Acquired anhidrosis and/or ...
I Want to Die. I cant deal with cholinergic urticaria. I cant stand this anymore! Why am I even still attending classes in college!? Why should I get a career? Its over! My life was over the minute cholinergic urticaria showed up! I cant do anything! I cant leave my apartment, I cant exercise.. I cant even make friends because I get nervous when I meet new people!
... How am I going to work at a job with cholinergic urticaria? Find out ways to make money online, earn a living, start a career, avoid disability, and more with hives.
This guidance for the management of patients with chronic urticaria and angioedema has been prepared by the Standards of Care Committee of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a Web-based system. Their comments and suggestions were carefully considered by the Standards of Care Committee. Where evidence was lacking, a consensus was reached by the experts on the committee. Included in this management guideline are clinical classification, aetiology, diagnosis, investigations, treatment guidance with special sections on children with urticaria and the use of antihistamines in women who are pregnant or breastfeeding. Finally, we have made recommendations for potential areas of ...
Urticaria. View of an urticaria rash on the skin of a 59 year old womans trunk. Urticaria is seen here as the appearance of several small red raised itchy areas on the skin. Urticaria is also known as hives, or nettle rash. It has many causes, including stress, heat, cold or sunlight, but most commonly it is caused by an allergic reaction. This may be to an ingredient in a food (such as an artificial colouring), the food itself (such as shellfish or eggs) or to a drug (such as aspirin). The condition usually clears up naturally after a few hours, although calamine lotion or anti- histamine drugs may be used to reduce the itching. - Stock Image M280/0158
Urticaria. Close-up of urticaria (red) on a 1-year-old male patient following an episode of hand foot and mouth disease (HFMD). Urticaria, also known as nettle rash or hives, is a skin condition in which a rash of itchy wheals or lumps develops on the skin, usually on the trunk or limbs. The wheals appear in a matter of minutes and usually fade after a few hours. Urticaria most often occurs as an acute allergic response, triggered, for instance, by particular foods or drugs. It can also result from heat, cold, sunlight or, less frequently, other medical conditions like cancer. HFMD is caused by intestinal viruses of the picornaviridae family. - Stock Image C026/9180
Delayed pressure urticaria: Find the most comprehensive real-world symptom and treatment data on delayed pressure urticaria at PatientsLikeMe. 18 patients with delayed pressure urticaria experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Cannabidiol, Ibuprofen, and Sulfasalazine to treat their delayed pressure urticaria and its symptoms.
Although omalizumab (anti-IgE) is currently only approved for the treatment of asthma and chronic idiopathic urticaria, it has also been studied as an off-label treatment for numerous allergic conditions, including use as an adjunct to allergen immunotherapy in the treatment of allergic rhinitis, asthma, venom hypersensitivity and food allergy. We conducted a review of publications involving the use of omalizumab with allergen immunotherapy, by searching PubMed with key search terms of "omalizumab" and "immunotherapy." Omalizumab has been used in combination with inhalant allergen immunotherapy for the treatment of seasonal allergic rhinitis and comorbid asthma. Read More ...
Urticaria (hives) is a vascular reaction of the skin marked by the transient appearance of smooth, slightly elevated patches (wheals) that are erythematous and that are often attended by severe pruritus. Individual lesions resolve without scarring in several hours.
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Chronic urticaria (CU) involves release of histamine from mast cells and/or basophils, which in turn promotes the classic inflammatory cascade. The resultant symptoms can severely impact sufferers quality of life and in severe cases prevent them from leading a normal existence, with consequent burdens on family and society. Rapid initiation of effective reliable therapy is important in combating CU, together with avoidance of triggers or exacerbating factors, if known. While newer immunologically-based therapies are beginning to be developed, antihistamines remain a cornerstone of effective therapy. Treatment should be tailored to individual patient circumstances, but in principle the choice of antihistamine component should be governed by the availability of evidence of rapid and prolonged efficacy specifically in CU and evidence of good tolerability and safety. Increasingly, evidence of beneficial effects on patient quality of life is also required for rational selection of an antihistamine from
... CONTINUING OTC EDUCATION Acute urticaria can also be caused by sunlight, heat, cold, water, pressure, vibration,