In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction agmatine + H2O ⇌ {\displaystyle \rightleftharpoons } putrescine + urea Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups. In humans, the enzyme is encoded by the AGMAT gene. As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI. Piperazine-1-carboxamidine GRCh38: Ensembl release 89: ENSG00000116771 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000040706 - Ensembl, May 2017 Human PubMed Reference:. Mouse ...

The SCOP classification for the Creatinase/prolidase N-terminal domain superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.

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This work presents the synthesis and spectroscopic characterization of novel methoxy and hydroxy derivates of amidino substituted benzimidazoles and benzamides. Novel compounds were prepared by classical reactions of organic chemistry. Hydroxy derivates of amidino substituted benzimidazoles 13-18 were prepared by the condensation reaction from 4-amidino substituted 1,2-phenylenediamine hydrochlorides 8 and 9 with aromatic aldehydes. In the condensation of corresponding methoxy substituted benzoyl-chlorides 19-21 with p-cyanoaniline methoxy substituted N-(4-cyanophenyl)benzamides 26-28 were prepared. Hydroxy substituted benzamide derivates 29-31 were prepared removing methoxy protection groups using reagents BCl3 and BBr3. Amidino substituted benzamide derivates 33-36 were prepared in the acidic Pinner reaction from the corresponding cyano substituted benzamides 29-30. The Pinner reaction was monitored with IR spectroscopy while the structures of all newly prepared compounds were confirmed by ...

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Affiliation：九州女子大学,家政学部,准教授, Research Field：Functional basic dentistry,Functional biochemistry,Functional basic dentistry,Rehabilitation science/Welfare engineering, Keywords：唾液腺,動物進化,Animal evolution,カエルアラントイナーゼcDNA,Purine degradation,Allantoinase,アラントイナーゼ,アラントイカーゼ,Frog allantoinase cDNA,Allantoicase, # of Research Projects：8, # of Research Products：16, Ongoing Project：高齢者の口腔咽頭機能評価に対する舌の立体認知能・運動能からのアプローチ

This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholino antisense oligonucleotides (MAOs) were used to inhibit translation of mRNAs for ODC1 alone, AGMAT alone, and their combination. Rambouillet ewes (N = 50) were assigned randomly to the following treatments on Day 8 of pregnancy: MAO control (n = 10); MAO-ODC1 (n = 8); MAO-ADC (n = 6); MAO-ODC1:MAO-ADC (n = 9); or MAO-ODC1:MAO-AGMAT (n = 9 ...

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Alright starting another log. I was lucky enough to be chosen by BPS to log some EndoSurge and then AI chose me to log Stoked and Agmatine. Pretty

am1a04d AJ229366 409 3.0 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) C. albicans 3.4 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) C. tropicalis 5.8 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) P. stipitis am2f05d AJ229451 261 6.0 E-18 Putative agmatinase precursor (EC 3.5.3.11) S. pombe 2.0 E-08 Possible agmatinase (EC 3.5.3.11) S. clavuligerus 4.9 E-06 Hypothetical agmatase (EC 3.5.3.11) M. fervidus okam5d07r AJ229891 230 0.1 E-10 Beta-ketoacyl-ACP reductase (EC 1.1.1.100) C. lanceolata 0.2 E-10 Hypothetical protein 5 Xanthobacter sp 6.3 E-10 Hypothetical oxidoreductase B. subtilis am2d01d AJ229435 151 2.9 E-07 YOL5_CAEEL hypothetical 45.3 KD protein C. elegans okam1d10r AJ229574 268 0.2 E-06 Acetamidase (EC 3.5.1.4) A. nidulans ...

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Agmatine Sulfate - Nitric Oxide Perpetual Pump WHAT IS AGMATINE? Agmatine is a small molecule that the body makes naturally from the amino acid, arginine. Agmatine is a decarboxylized Arginine metabolite. More simply, Agmatine is what Arginine becomes within the body. Agmatine has dual functions: A) Selective inhibitio

Agmatine: | | Agmatine | | | ||| | | |... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.

I recall reading that NPs bulk agmatine was tested by a thirds party and wasnt agmatine.Im pretty sure that this was also the case with a coupe

The first synthesis and elucidation of the cocaine molecule was by Richard Willstätter in 1898. Willstätters synthesis derived cocaine from tropinone. Since then, Robert Robinson and Edward Leete have made significant contributions to the mechanism of the synthesis. The biosynthesis begins with L-Glutamine, which is derived from L-ornithine in plants. The major contribution of L-ornithine and L-arginine as a precursor to the tropane ring was confirmed by Edward Leete. Ornithine then undergoes a PLP-dependent decarboxylation to form putrescine. In animals, however, the urea cycle derives putrescine from ornithine. L-ornithine is converted to L-arginine, which is then decarboxylated via PLP to form agmatine. Hydrolysis of the imine derives N-carbamoylputrescine followed with hydrolysis of the urea to form putrescine. The separate pathways of converting ornithine to putrescine in plants and animals have converged. A SAM-dependent N-methylation of putrescine gives the N-methylputrescine product, ...

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.

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The usual form of many supplements of vitamin A from cod-liver oil is a gelatin capsule. This inactivates most or all benefit from the vitamin A and fatty acids it is supposed to supply, and now we learn it also inactivates the DPP IV enzyme necessary to digest peptides. Do not use vitamin A capsules.

Putative Permease; Member Of The Allantoate Transporter Subfamily Of The Major Facilitator Superfamily; Mutation Confers Resistance To Ethionine Sulfoxide

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Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.

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The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Origin: Derived from L-Arginine through decarboxylation.. Also Known As: (4-aminobutyl)guanidine. Overview: Agmatine Sulfate is stored within neurons and is released during neuronal activation. It regulates the levels of Nitric Oxide when elevated within the body. Agmatine Sulfate also appears to do much of the same things as Arginine but at a greater rate of potency. It has a decidedly Nootropic effect and can help people achieve a mental edge, whether in or out of the gym or athletic training.. Common Dosage: The common dosage for agmatine ranges between 100 mg and 1000 mg depending on the intended use.. ...

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One subfamily of guanidino group-modifying enzymes (GMEs) consists of the agmatine deiminases (AgDs). These enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia. In plants, viruses, and bacteria, these enzymes are thought to be involved in energy production, biosynthesis of polyamines, and biofilm formation. In particular, we are interested in the role that this enzyme plays in pathogenic bacteria. Previously, we reported the initial kinetic characterization of the agmatine deiminase from Helicobacter pylori and described the synthesis and characterization the two most potent AgD inactivators. Herein, we have expanded our initial efforts to characterize the catalytic mechanisms of AgD from H. pylori as well as Streptococcus mutans and Porphyromonas gingivalis. Through the use of pH rate profiles, pK(a) measurements of the active site cysteine, solvent isotope effects, and solvent viscosity effects, we have determined that the AgDs, like PADs 1 and 4

A number of aromatic mono- and bis-amidines are capable ofblocking cell fusion induced by Respiratory Syncytial (RS) virus.Suitable amidino compounds include those selected from the groupconsisting of 1-4-di(4-amidino-phenoxy)-2-butanol;bis(5-amidino-2-benzimidazolyl)methane;1,2-bis(5-amidino-2-benzimidazolyl)ethane; 5-amidino-indole;5-amidinobenzimidazole,

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Looking for agmatine? Find out information about agmatine. C5H14N4 Needlelike crystals with a melting point of 231°C; soluble in water; a product of the enzymatic decarboxylation of arginine Explanation of agmatine

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Agmatine, also known as (4-aminobutyl)guanidine, is a derivative of the amino acid l-arginine. Stored in neurons, this compound (also referred to as super argi

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Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses (embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine (Agm) by arginine decarboxylase (ADC), and Agm is converted to putrescine by agmatinase (AGMAT). Morpholino antisense oligonucleotides (MAOs) were designed and synthesized to inhibit translational initiation of the mRNAs for ODC1 and ADC, in ovine conceptuses. The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC (MAO-ODC1:ADC)

Blattabacterium strain Bge is the primary endosymbiont of the cockroach Blattella germanica. It is a Gram-negative maternally inherited bacteria which lives in specialized cells in the hosts abdominal fat body. Phylogenetic analyses for the Blattabacterium-cockroach symbiosis supports the hypothesis of co-evolution between symbionts and hosts dating back to more than 140 million years ago. Cockroaches are omnivorous insects, often subsisting on a nitrogen-poor diet, and Blattabacterium have been hypothesized to participate in uric acid degradation, nitrogen assimilation, and nutrient provisioning. Genome sequencing and metabolic reconstruction shows that Blattabacterium can recycle nitrogen from urea and ammonia, which are uric acid degradation products, into glutamate, using urease and glutamate dehydrogenase, and thus would be able to provide its host with some essential amino acids, vitamins and cofactors. The bacterium relies on Pro, Gln and Asn supplied by the host. It encodes the complete ...

Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/beta-lactamase-type fold with highest structural similarity to the class A beta-lactamases fused to an N-terminal domain with a fold similar to steroid isomerases and polyketide cyclases. The C-terminal domain of ORF12 did not show beta-lactamase or PBP activity for the substrates tested, but did show low-level esterase activity towards 3-O-acetyl cephalosporins and a thioester substrate. Mutagenesis studies imply that Ser173, which is present in a conserved SXXK motif, acts as a nucleophile in catalysis, consistent with studies of related esterases, beta-lactamases and d-Ala carboxypeptidases. Structures of wild-type ORF12 and of catalytic residue variants were obtained in complex with and in the absence of clavulanic acid. The role of ORF12 in ...

Urea Amidolyase; Contains Both Urea Carboxylase And Allophanate Hydrolase Activities, Degrades Urea To CO2 And NH3; Expression Sensitive To Nitrogen Catabolite Repression And Induced By Allophanate, An Intermediate In Allantoin Degradation; Protein Abundance Increases In Response To DNA Replication Stress

gmatine is a relatively new compound in the supplement market that is gaining popularity. So why is Agmatine useful and why do some refer to it as a Super Arginine? Amatine is a metabolic byproduct of Arginine produced through a process called decarboxylation. Agmatine is basically Arginine with the carboxylic acid end removed. Agmatine produces the byproducts Guanidino-butyladehyde and the polyamines putruscene, spermine, and spermidine which are involved in cell growth. Agmatine is found in tissues throughout the body and is synthesized and stored astrocytes, glial cells in the brain and spinal cord, which provide structural and metabolic support to the nervous system among other actions. Agmatine acts as a neurotransmitter and neuromodulator with a vast array of actions in the body. Promotes the release of insulin and uptake of calcium in pancreatic cells supporting healthy insulin sensitivity. Supports the release of catecholeamines assisting in stress management. Inhibits Nitric Oxide Synthase

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