Uracil Mustard: Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
  Welcome to the Antimicrobial Stewardship (AMS) Hub, hosted as part of a PrescQIPP collaboration with NHS Improvement to support CCG Antimicrobial Stewardship activity in particular delivery of the Quality Premium. This work has been led by
Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977 ...
Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977 ...
DESCRIPTION WARNING TAXOL® (paclitaxel) Injection should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possibl...
In 1930, John S. Lundy started using the structural formula of Na (sodium salt) and named pentobarbital as Nembutal. However, the first recorded discovery of the drug goes back to in 1864 when Von Baeyer first synthesized malonylurea. In 1934, Von Mering and Fisher followed the synthesis of pentobarbital of the same drug group. The new synthesis brought the birth of different barbiturates such as amobarbital, secobarbital, pentobarbital, thiopental.. In the United States, the Danish pharmaceutical company named Lundbeck is the only distributor that has an approval for pentobarbital injectable.. ...
Background In recent years it has become evident that nonsteroidal anti-inflammatory drugs, in particular aspirin represent a potential class of cancer chemotherapeutic agents. Despite the wealth of...
Water quality - Determination of the genotoxicity of water and waste water - Salmonella/microsome fluctuation test (Ames fluctuation test)
Another interesting question is to what extent might the N methylation contribute to the bioavilability (the ADMET profile) in amide of small molecules rather than peptides ? For example, Tubulin-binding taxanes such as paclitaxel and docetaxel are important cancer chemotherapeutic agents. However, these drugs suffer from limitations such as poor aqueous solubility and oral bioavailability, emerging drug resistance, and the lack of blood-brain barrier permeability ...
To our knowledge, maspin is the only serpin that sensitizes apoptosis, whereas all of the other serpins thus far implicated in apoptosis regulation appear to be antiapoptotic (17 , 32 , 33) . Thus, the existing literature offers little insight into the possible molecular mode of maspin action. The goal of the present study was to identify the specific target molecule(s), the modification of which by maspin sensitizes prostate and breast tumor cells toward potential cancer chemotherapeutic agents. By using multiple maspin-transfected cell lines in vitro, we obtained cellular, molecular, and biochemical evidence that supports a key role for Bax in maspin-mediated apoptosis sensitization. Although we may not have exhausted our search because of the ever-growing number of apoptosis regulators, our data seem sufficient to support our new hypothesis that the specific up-regulation of Bax, without changing Bcl-2, Bcl-xl, and Bak expression in maspin-transfected cells, may tip the balance of pro- versus ...
Sartorelli, A; Shansky, C; and Lin, A, "Transport of nitrogen mustard (hn2) in hn2-sensitive and -resistant sarcoma 180 ascites cells. Abstr." (1972). Subject Strain Bibliography 1972. 454 ...
Looking for online definition of nitrogen mustard in the Medical Dictionary? nitrogen mustard explanation free. What is nitrogen mustard? Meaning of nitrogen mustard medical term. What does nitrogen mustard mean?
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
The DNA photoaffinity ligands, 7-azidoactinomycin D and 8-azidoethidium, form DNA adducts that cause chain cleavage upon treatment with piperidine. Chemical DNA sequencing techniques were used to detect covalent binding. The relative preferences for modifications of all possible sites defined by a base pair step (e.g. GC) were determined within all quartet contexts such as (IGCJ). These preferences are described in terms of effective site occupations, which expressthe ability of a ligand to covalently modify some base in the binding site. Ideally, the effective site occupations measured for photoaffinity agents can also be related to site-specific, non-covalent association constants of the ligand. The sites most reactive with 7-azidoactinomycin D were those preferred for non-covalent binding of unsubstituted actinomycin D. GC sites were most reactive, but next-nearest neighbors exerted significant influences on reactivity. GC sites in 5′-(pyrimidine)GC(purine)-3′ contexts, particularly ...
Dose-limiting toxicity of many cancer chemotherapeutic agents is peripheral neuropathy. Our data suggest that peripheral neuropathy may be reduced with the addition of glutamine in patients receiving high-dose paclitaxel as the first part of a tandem high-dose chemotherapy regimen. Glutamine appeared to reduce both the incidence and severity of symptoms previously observed with this dose. In addition, some of the signs of peripheral neuropathy were also reduced (vibration sense at the toes, interference with ADLs, gait, sensory deficits to pinprick) in patients who received glutamine compared with those who did not. Because a large proportion (38%) of the patients entered this trial with abnormal reflexes, it is not surprising that this parameter did not show any difference between the two groups. We opted to use the glutamine source cited in the original report because it is unknown whether all glutamine preparations are equivalent. The product that we used did not contain antioxidants because ...
Gleostine® (lomustine) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.. Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to bleeding and overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of Gleostine® (see WARNINGS and ADVERSE REACTIONS).. Since the major toxicity is delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose (see ADVERSE REACTIONS). At the recommended dosage, courses of Gleostine® should not be given more frequently than every 6 weeks.. The bone marrow toxicity of Gleostine® is cumulative and therefore dosage adjustment must be considered on the basis of nadir blood counts from prior dose (see dosage adjustment table under DOSAGE AND ADMINISTRATION). more ,, ...
Synonyms for mustard in Free Thesaurus. Antonyms for mustard. 4 synonyms for mustard: table mustard, mustard greens, Indian mustard, leaf mustard. What are synonyms for mustard?
Learn how to grow Mustard Greens with our simple step by step guide. Mustard greens, also known as Indian mustard, Chinese mustard and leaf mustard, is a species of mustard plant.