TY - JOUR. T1 - Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells. AU - Olave, Nélida C.. AU - Grenett, Maximiliano H.. AU - Cadeiras, Martin. AU - Grenett, Hernan E.. AU - Higgins, Paul J.. PY - 2010/10/15. Y1 - 2010/10/15. N2 - The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs). Transfection of PAI-1 promoter-luciferase reporter deletion constructs identified a 251-bp fragment (nucleotides -800 to -549) responsive to Quer. Two E-box motifs (CACGTG), at map positions -691 (E-box1) and -575 (E-box2), are platforms for occupancy by several members of the c-MYC family of basic helix-loop-helix leucine zipper (bHLH-LZ) proteins. Promoter truncation and electrophoretic mobility shift/supershift analyses identified upstream stimulatory factor (USF)-1 and USF-2 as E-box1/E-box2 binding factors. ECs ...
A single-nucleotide polymorphism (C/A) located within an E-box at the −20 position of the human angiotensinogen (AGT) promoter may regulate transcriptional activation through differential recruitment of the transcription factors upstream stimulatory factor (USF) 1 and 2. To study the contribution of USF1 on AGT gene expression, mice carrying a (−20C) human AGT (hAGT) transgene were bred with mice harboring a USF1 gene trap allele designed to knock down USF1 expression. USF1 mRNA was reduced relative to controls in liver (9±1%), perigenital adipose (16±3%), kidney (17±1%), and brain (34±2%) in double-transgenic mice. This decrease was confirmed by electrophoretic mobility shift assay. Chromatin immunoprecipitation analyses revealed a decrease in USF1, with retention of USF2 binding at the hAGT promoter in the liver of male mice. hAGT expression was reduced in the liver and other tissues of female but not male mice. The decrease in endogenous AGT expression was insufficient to alter ...
Upstream Stimulatory Factors: Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Complete information for USF1 gene (Protein Coding), Upstream Transcription Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Maria Vega-RodriguezPh.D. in Biological OceanographyAdvisor: Dr. Frank Muller-KargerLab Phone: 727.553.1186Email: [email protected]
Training & Recruitment CoordinatorSocial ScientistPh.D., International Seminary, 2009Office Phone: 727.553.3921Email: [email protected]: View PDF A...
Looking for online definition of B-Cell Stimulatory Factor 1 in the Medical Dictionary? B-Cell Stimulatory Factor 1 explanation free. What is B-Cell Stimulatory Factor 1? Meaning of B-Cell Stimulatory Factor 1 medical term. What does B-Cell Stimulatory Factor 1 mean?
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Low plasma SHBG levels are a biomarker of the metabolic syndrome and a harbinger of its associated pathologies. In insulin-resistant individuals, elevated insulin levels have been linked to low plasma SHBG levels, but hyperglycemia is also usually present in conjunction with hypertriglyceridemia. To discriminate the direct effects of insulin and blood sugars on human SHBG gene expression in vivo, we used mice in which human SHBG transgenes are expressed under the control of their own regulatory sequences in an appropriate tissue-specific manner (21, 22). Previous studies have defined the transcription unit responsible for human SHBG gene expression in the liver (21) and mapped key regulatory elements within a proximal promoter sequence (22), which includes a binding site for USF transcription factors (24) that we previously assumed might represent part of a carbohydrate response element (22). However, removal of this USF binding site from a human SHBG transgene has no impact on the rapid ...
Although no functional studies to assess the role of the described HAMP polymorphism on hepcidin expression have been performed, our findings suggest that the presence of this polymorphic variant might play a role in iron metabolism of poly-transfused thalassemic patients,11-14 perhaps changing the response to the transcriptional activation by both upstream stimulatory factors 1 and 2 (USF1/USF2) and cMyc/Max heterodimers that occur through E-boxes within the promoter, as shown by Bayele.5 Alterations of these elements might render the promoter less responsive to USF1/USF2 or c-Myc/Max, modifying regulation of the hepcidin transcription factors and its function in iron metabolism.5. The c.-582 A,G HAMP-P variant did not show an impact on the level of iron loading in the regular chelated patients, while it influenced the LIC values and the serum ferritin among the patients receiving an irregular chelation treatment. These observations suggest that this HAMP-P polymorphism may be associated with ...
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FAA aeronautical and local business information for airport Meadow Creek Usfs (0S1), MT, US, covering airport operations, communications, weather, runways, comments and remarks, approach plates and procedures, services, all reporting businesses and FBOs, and kneeboard print outs.
Limiting dilution analyses with the Poisson model were performed on normal mouse spleen cells alone or in the presence of added cells or soluble factors. When a constant number of T cells activated to sheep red blood cells were added to cultures of diluted spleen cells the mean frequency of response to sheep red blood cells was 5- to 30-fold greater than that of spleen cells diluted alone. Adding a constant number of B cells did not produce a significant change in the mean frequency of response of diluted spleen cells. Since a responding unit is thought to be composed of T cells and B cells, these results indicate that antigen-specific T cells normally limit the generation of responding units when normal spleen cells are subjected to limiting dilution analysis alone. Conversely, B cells appear to be in relative excess.. Culture medium supernatants from mixed cultures of T cells activated to histocompatibility antigens and target cells bearing the antigens to which the T cells have been activated ...
Event: USF ID Grand Rounds. Date & Time: 1/21/14, 6pm. Location: 17 Davis, Suite 407. Title: "Zoonoses From Pets Other Than Cats & Dogs". Speaker: Dr Lily Jones, DO, USF Infectious Disease Fellow. ...
In this article we look at condensed research conducted by USF colleagues in order to learn about the many facets of gaming for education.
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Vevo eBox provides an option to maintain physiological monitoring in situations where affixing a subject animal to the table is not possible. Learn more.
We have shown previously that fatty acid synthase (FAS) gene expression is positively regulated by glucose in rat adipose tissue and liver. In the present study, we have identified in the first intron of the gene a sequence closely related to known glucose-responsive elements such as in the L-pyruvate kinase and S14 genes, including a putative upstream stimulatory factor/major late transcription factor (USF/MLTF) binding site (E-box) (+ 292 nt to + 297 nt). Location of this sequence corresponds to a site of hypersensitivity to DNase I which is present in the liver but not in the spleen. Moreover, using this information from a preliminary report of the present work, others have shown that a + 283 nt to + 303 nt sequence of the FAS gene can confer glucose responsiveness to a heterologous promoter. The protein binding to this region has been investigated in vitro by a combination of DNase I footprinting and gel-retardation experiments with synthetic oligonucleotides and known nuclear proteins. ...
Definition of e-box elements in the Definitions.net dictionary. Meaning of e-box elements. What does e-box elements mean? Information and translations of e-box elements in the most comprehensive dictionary definitions resource on the web.
Principal Investigator:MATSUSHIMA Kiyoshi, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Conservative dentistry
The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly
The 35-year-old federal law regulating tap water is so out of date that the water Americans drink can pose what scientists say are serious health risks - and still be legal. The New York Times analyzed the results of more than 19 million drinking water tests.
Dr. Zesiewiczs and Dr. Sanchez-Ramos USF Parkinsons Disease and Movement Disorders Center is located in the Morsani Center for Advanced Health Care on the USF Main Campus on USF Laurel Drive.. Parkinsons Disease Clinic ...
Program information for the Elementary Cohort Degree plan in the bachelor of science at USF. See program highlights and student opportunities.
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get them in front of Issuus millions of monthly readers. Title: AlumniVoice_April2011_finalLR.pdf, Author: USF Alumni Association, Name: AlumniVoice_April2011_finalLR.pdf, Length: 40 pages, Page: 1, Published: 2011-05-05
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Looking for online definition of B cell stimulatory factor II in the Medical Dictionary? B cell stimulatory factor II explanation free. What is B cell stimulatory factor II? Meaning of B cell stimulatory factor II medical term. What does B cell stimulatory factor II mean?
USF is a family of transcription factors characterized by a highly conserved basic-helix-loop-helix-leucine zipper (bHLH-zip) DNA-binding domain. Two different USF genes, termed USF1 and USF2, are ubiquitously expressed in both humans and mice. The USF1 and USF2 proteins contain highly divergent transcriptional activation domains but share extensive homologies in the bHLH-zip region and recognize the same CACGTG DNA motifs. Although the DNA-binding and transcriptional activities of these proteins have been characterized, the biological function of USF is not well understood. Here, focus- and colony-formation assays were used to investigate the potential involvement of USF in the regulation of cellular transformation and proliferation. Both USF1 and USF2 inhibited the transformation of rat embryo fibroblasts mediated by Ras and c-Myc, a bHLH-zip transcription factor that also binds CACGTG motifs. DNA binding was required but not fully sufficient for inhibition of Myc-dependent transformation by ...
Whats a transcription factor of the basic helix-loop-helix leucine zipper family doing in the cytoplasm? Sans et al. explored why nearly all of the transcription factor MondoA and its binding partner protein called Mlx is found in the cytoplasm but the protein appears to function as a transcription factor in the nucleus. The authors found that in primary cultures of human muscle or erythroblast cells, MondoA and Mlx were associated with the mitochondria. Inhibition of nuclear shuttling of the proteins with an inhibitor of the CRM1 nuclear export factor caused MondoA (detected by confocal immunofluorescence microscopy) to accumulate in the nucleus. Thus, the authors suspected that MondoA could function to carry signals from the mitochondria to the nucleus. They obtained further circumstantial evidence for such a role from microarray experiments designed to detect genes transcribed in response to MondoA and Mlx. MondoA-Mlx regulated a broad range of targets, which included many genes associated ...
human MONDOA protein: basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network; RefSeq NM_014938
Mouse monoclonal antibody raised against a partial recombinant USF2. USF2 (NP_003358, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00007392-M01A) - Products - Abnova
People who consent to participate RCTs are willing to be randomly allocated to new or existing treatments. While RCTs are considered the gold standard for comparing the effects of one treatment to another, the gradual progress they yield can seem frustratingly slow - particularly for patients with poor standard treatment options.. Yet, the genuine uncertainty associated with individual RCTs has been vital to the gains in therapeutics, said Dr. Djulbegovic, professor of medicine and oncology at the USF Health Morsani College of Medicine and Moffitt Cancer Center. If there was significant likelihood that one treatment in a comparison was better than the other, it would be unethical to deny some patients the superior treatment, and well-informed patients would probably refuse to participate in the study, he said.. Incremental advances in treatment generated by RCTs over time - such as childhood leukemia cure rates moving from zero to 80 percent even though only 2 to 5 percent of new treatments ...
The information in this brochure is intended to educate the general public and increase awareness of the positive aspects of LPDs and how to avoid conflicts when in areas where they may exist. The brochure can be found at trailheads, informational kiosks, and Forest Service Visitor Centers throughout the United States. As a visual mechanism to complement the brochure, informational signs are being made visible in key areas throughout USFS and BLM grazing allotments where both recreationalists and LPDs may occur.. ...
IL12A - IL12A (Myc-DDK-tagged)-Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A) available for purchase from OriGene - Your Gene Company.
News for Scientific Instruments continually updated from thousands of sources on the web : II-VI, USF Complete First Phase of Thin-Film Partnership
DISCLAIMER: The information shown on these maps has been obtained from various sources (Tele Atlas North America Inc., WDNR, BCPL, WDOT, USFS, USGS, etc.), and are of varying age, reliability and resolution. These maps are not intended to be used for navigation, nor are these maps an authoritative source of information about legal land ownership or public access. Users of these maps should confirm the ownership of land through other means in order to avoid trespassing. No warranty, expressed or implied, is made regarding accuracy, applicability for a particular use, completeness, or legality of the information depicted on this map. ...
Dangerous: respect the precautions for use (established according to the European regulations in force for classification and labelling of chemicals). Before each use, read the label and the information concerning the product. Storage between +5°C and +35°C. Reserved for professional use. Medical device Class IIa (complies with medical devices directive 93/42/EEC modified).. ...
Bethesda, Maryland (PRWEB) March 15, 2013 -- CME Outfitters (CMEO), a leading accredited provider in continuing medical education, in collaboration with USF
USF President Judy Genshaft said the medical school and cardiovascular institute will be a key anchor for the $3 billion redevelopment project expected to span 50-plus acres in downtown Tampa.
INTO USF offers international students the opportunity of gaining an American college experience at the University of South Florida.
Multinucleated osteoclasts differentiate from hematopoietic progenitors of the monocyte/macrophage lineage. Because of its pivotal role in bone resorption, regulation of osteoclast differentiation is a potential therapeutic approach to the treatment of erosive bone disease. In this study, we have found that fucoidan, a sulfated polysaccharide extracted from brown seaweed, inhibited osteoclast differentiation. In particular, addition of fucoidan into the early stage osteoclast cultures significantly inhibited receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL)-induced osteoclast formation, thus suggesting that fucoidan affects osteoclast progenitors. Furthermore, fucoidan significantly inhibited the activation of RANKL-dependent mitogen-activated protein kinases (MAPKs) such as JNK, ERK, and p38, and also c-Fos and NFATc1, which are crucial transcription factors for osteoclastogenesis. In addition, the activation of NF-κB, which is an upstream transcription factor modulating NFATc1
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Transcription factor EB (TFEB) is a member of the MiTF/TFE (Microphthalmia/TFE) subfamily of basic/helix-loop-helix/leucine zipper transcription factors. This group of proteins is involved in the proliferation and development of specific cell types such as osteoclasts or melanocytes.
Excellgen MAX (Myc-Associated Factor X) [RP-122] - Product Name MAX (Myc-Associated Factor X) Size 10,000 U Description The MAX gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA-binding site of Myc. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ)
Rabbit polyclonal antibody raised against a full-length human USF2 protein. USF2 (NP_003358.1, 1 a.a. ~ 346 a.a) full-length human protein. (H00007392-D01P) - Products - Abnova
Macromolecular depositoning and patterning technology developed at the USF Surface Science Lab is now commercially available! Check here for more info. ****We are currently looking for Ph.D. students to join our efforts. Projects on inorganic-organic hybrid materials interfaces, and atomic layer deposition (ALD) related projects recently received NSF funding. Undergraduates with research interests are also welcome to join during semesters or summers on a flexible schedule. Honors thesis related projects are also available. Foreign students in search of diploma, masters, or intenship (studienarbeit/ praktikum) research projects are also encouraged to apply.****. Welcome to the USF Surface Science Laboratory! The SSL focuses on the application of surface scientific techniques on molecular and nano structured materials. A particular focus is the investigation and fabrication of macro-molecular interfaces. Some of the investigated topics are:. ...
The CDPA increased the proportion of status 1 lands in the Mojave region by approximately 150%, from 14 to 36% (Table MOJ-1, Figure MOJ-2). Fifty-seven status 1 managed areas were mapped for the region, including those established by the CDPA. Of these, BLM manages 41 wilderness areas. There are also 5 USFS wilderness areas, 3 national park units, 3 TNC preserves, 2 CDF&G ecological reserves, 1 state reserve, and 2 UC natural reserves. The vast majority of status 1 land area is managed currently by the NPS, with over 20,000 km², followed by BLM with over 6,000 km², mostly in wilderness areas. Other status 1 areas total less than 100 km² per agency. The management profiles of the two floristic subregions are quite different (Table MOJ-2). The majority of the status 1 managed area is in the eastern subregion, with very little status 4 land. The western Mojave, on the other hand, has a more modest amount of status 1 and 2 land with nearly half in status 3 and a third in status 4. The western ...
In January of 1994, the Chief of the U.S. Forest Service (USFS) and the Director of the Bureau of Land Management (BLM) initiated what was then called the Eastside Ecosystem Management Project to develop a scientifically sound and ecosystembased strategy for management of forests eastside forests.
Wolves are federally "Listed" under the ESA in nearly all Lower 48 States. Urban-controlled states like CA, IL and WA also protect them under strict state laws while rural states like UT and ND try to keep them out. Other states like MN remain quiescent explaining moose declines as due to climate change and an attack on a sleeping camper in a USFS campground as due to a wolf with a "deformed brain". The majority of all states with wolves publish questionable data, cover-up attacks and damages, and generally divert funds and manpower clandestinely as they attempt to navigate these political rapids with their feet in two canoes - one belonging to powerful urban political pro-wolf lobby groups; the other belonging to those rural residents putting up with one wolf outrage after another as wolves (like dogs and coyotes) learn to evade controls, expand their territories and find new food sources in the "food-rich" and "unused-to-wolves" settled landscapes of the Lower 48. I have met rural mothers that ...