The co-primary endpoint of change in percent atheroma volume was reduced by a mean of 0.98% (p < 0.001 vs. baseline). Regression in percent atheroma volume was observed in 63.6% of patients and progression in 36.4%. The other co-primary endpoint, change in nominal atheroma volume in the 10 mm subsegment with the greatest disease severity at baseline, was also reduced (mean -6.1 mm3, p < 0.001 vs. baseline). Total atheroma volume was also reduced at follow-up by a mean of -14.7 mm3 (p < 0.001). IVUS results were similar in the prespecified subgroups. Adverse events leading to study drug discontinuation included musculoskeletal complaints (3.7%) and cardiovascular disorders (4.3%). There were no cases of rhabdomyolysis.. ...
TY - JOUR. T1 - Intravascular ultrasound predictors of target lesion revascularization after stenting of protected left main coronary artery stenoses. AU - Hong, Myeong Ki. AU - Mintz, Gary S.. AU - Hong, Mun K.. AU - Pichard, Augusto D.. AU - Satler, Lowell F.. AU - Kent, Kenneth M.. AU - Popma, Jeffery J.. AU - Leon, Martin B.. PY - 1999/1/15. Y1 - 1999/1/15. N2 - We evaluated the predictors of late clinical outcomes after stenting of protected left main coronary artery (LMCA) stenoses. Intravascular ultrasound (IVUS) guided stenting of protected LMCA stenoses was performed in 87 consecutive patients between January 1994 and December 1996. Results were evaluated using conventional (clinical, angiographic, and IVUS) methodology. Late (12 month) clinical follow-up information was obtained in all patients. Initial procedural success was achieved in 86 patients (99%). There was 1 in- hospital death (in the 1 patient with a procedural failure). There were no other in-hospital complications, ...
AIMS:. To investigate whether the use of intravascular ultrasound virtual histology (IVUS-VH) leads to any improvements in stent deployment, when performed in patients considered to have had an optimal percutaneous coronary intervention (PCI) by quantitative coronary angiography (QCA).. METHODS AND RESULTS:. After optimal PCI result (residual stenosis by QCA,30%), IVUS-VH was performed in 100 patients by protocol, with the option to use the information left to the discretion of the operators. Patients were categorised as: Group1 (n=54), where the IVUS-VH findings were used to evaluate the need for further optimisation of the stent deployment; and Group2 (n=46), where the IVUS-VH was documentary such that the stenting results were considered optimal according to QCA. Optimal stent deployment on IVUS-VH was defined as: normal stent expansion, absence of stent malapposition, complete lesion coverage as indicated by a plaque burden (PB%) between 30-40% and necrotic core confluent to the lumen,10% or ...
Traditionally, arterial remodeling has been assessed by the ratio of lumen and external elastic membrane area at the diseased region over the lumen and external elastic membrane area of an adjacent, presumed healthy, reference site at a single time point.16 However, this approach has several major limitations (eg, occurrence of atherosclerosis and remodeling in the reference site, effect of arterial tapering, and subjectivity in identifying a single presumed normal reference site).16 Recently, a serial approach was also introduced in which the lumen and external elastic membrane area in a given arterial region are compared between 2 time points.16 Although this approach is pathobiologically valid, it was not applicable in our experimental model because of the confounding effect of normal arterial growth on arterial remodeling. To overcome the limitations of the aforementioned remodeling approaches, we used a revised approach, which is basically a modification of the standard methodology for ...
Intravascular ultrasound (IVUS) is a catheter-based technique which provides high-resolution cross-sectional images of both, coronary lumen and vessel wall. Various scientific studies recently established IVUS as a valuable tool for the assessment of the natural history of coronary atherosclerosis and the effect of different pharmacological and non-pharmacological interventions on progression-regression of atherosclerosis. Novel technical approaches that use IVUS radiofrequency data may provide further interesting information on vessel wall characteristics but require further validation. In addition, numerous trials applied IVUS to assess the short- and long-term outcome of different percutaneous coronary interventions, including the implantation of drug-eluting stents. Besides the importance of IVUS in the field of scientific trials, IVUS can be clinically helpful for the evaluation of angiographically ambiguous lesions, guidance of catheter-based interventions, and management of complications. ...
Approach and Results-Ex vivo coronary NIRS and IVUS imaging was performed through blood in 116 coronary arteries of 51 autopsied hearts, followed by 2-mm block sectioning (n=2070) and histological grading according to modified American Heart Association criteria. Lesions were defined as the most heavily diseased 2-mm block per imaged artery on IVUS. IVUS-derived PB and NIRS-derived lipid core burden index (LCBI) of each block and lesion were analyzed. Block-level analysis demonstrated significant trends of increasing PB and LCBI across more complex atheroma (Ptrend ,0.001 for both LCBI and PB). Lesion-based analyses demonstrated the highest LCBI and remodeling index within coronary fibroatheroma (Ptrend ,0.001 and 0.02 versus all plaque groups, respectively). Prediction models demonstrated similar abilities of PB, LCBI, and remodeling index for discriminating fibroatheroma (c indices: 0.675, 0.712, and 0.672, respectively). A combined PB+LCBI analysis significantly improved fibroatheroma ...
We used optical coherent tomography (OCT) and virtual histology intravascular ultrasound (VH-IVUS) to assess culprit lesions in 146 Korean pts with acute coronary syndrome (ACS).. Methods: Culprit lesion plaque rupture (PR) or plaque erosion (PE) was diagnosed with OCT; and IVUS was used to determine arterial remodeling. PE (n=56) was the presence of intracoronary thrombus attached to the luminal surface with no detectable signs of fibrous cap rupture that was seen in 90 ACS pts with PR. Positive remodeling was a remodeling index (lesion/reference EEM [external elastic membrane] area) ,1.05.. Results: Pt age was 60±12 yrs in PR and 62±11 yrs in PE; 19% of PR vs 18% of PE were females. Overall, 25% (14/56) of PE had non-ST elevation myocardial infarction (NSTEMI) and 34% (19/56) had STEMI; conversely, 14.4% (13/90) of PR had NSTEMI and 71% (64/90) had STEMI (p,0.0001). Vessel size, minimal lumen area, and lumen area at the PR or PE site were similar; however, lesion length was longer in PR. ...
Data are mean value ± SD, unless otherwise indicated. ANOVA = analysis of variance; CSA = cross-sectional area; EEM = external elastic membrane; P+M = plaque plus media; Δ = change in.. ...
Intravascular ultrasonography is an invasive imaging procedure that provides intravascular images of the coronary arteries and other blood vessels. Intravascular ultrasonography has played a critical role in enhancing the understanding of coronary atherosclerosis pathophysiology and has facilitated the refinement of diagnostic and therapeutic...
0016]Turning initially to FIG. 1, a tissue/plaque characterization system 100 is schematically depicted. An intravascular ultrasound console 110 is communicatively coupled to an IVUS catheter 120. The IVUS catheter 120 comprises a distally mounted ultrasound transducer probe 122 that acquires backscatter data (e.g., IVUS data) from a blood vessel. In accordance with known IVUS catheters, the catheter 120 is maneuvered through a patients body (e.g., via a femoral artery) to a point of interest. The transducer probe 122 is then controlled, via the console 110 to emit ultrasound pulses and thereafter receive echoes or backscattered signals reflected from vascular tissue/plaque and blood. Because different types and densities of tissue absorb and reflect the ultrasound pulse differently, the reflected data (i.e., IVUS data) signals transmitted back to the console 110 by the IVUS catheter 120, is converted by characterization software into images of vascular objects. It should be appreciated that ...
In a previous report, Bocksch et al. [13]performed intravascular ultrasound in patients with an acute myocardial infarction before percutaneous transluminal coronary angioplasty. Intracoronary ultrasound permitted differentiation between pulsatile, low echogenic intraluminal material suggesting thrombus and mural highly echogenic atherosclerotic plaque in 22 (88%) of 25 patients. A negative silhouette of the intravascular ultrasound device was documented within the low echogenic material in 17 (68%) of 25 patients. Low echogenic intraluminal material was found in 18 (72%) of 25 segments proximal to and in 12 (48%) of 25 segments distal to the highly echogenic plaque, indicating prestenotic and post-stenotic thrombus [13]. Walton et al. [14]reported a case in which the intravascular ultrasonographic images obtained before angioplasty revealed total occlusion of the vessel, with plaque and bright speckled material suspected of being thrombus.. In the present study, there were four patients with ...
Color-flow intravascular sonography was introduced to provide a greater understanding of intraluminal blood flow, lumen size, success of endovascular treatment, and the interface between the vessel wall and the blood stream.7 Real-time images are produced from the transducer of the intravascular sonography apparatus at 30 frames per second. The difference between 2 sequential adjacent frames is detected by computer software producing the color-flow intravascular sonography images. Red demonstrates the movement of echogenic blood particles through the artery. A transition in the color representation from red to orange is seen when there is a vascular stenosis, resulting in an increase in the speed of blood through that segment.7 The main benefit of color-flow intravascular sonography lies in its ability to distinguish luminal blood flow from the dark echolucent disease along the vessel wall.19,60,61. Color-flow intravascular sonography can also identify soft echolucent plaques, ulcerations, ...
This randomized IVUS-guided versus angiography-guided DES implantation trial in long lesions demonstrated that a strategy of routine IVUS did not improve the MACE at 1 year following intervention. The IVUS use per operator decision was associated with improved results. Although there was only a trend toward a reduction in the primary endpoint (1-year MACE) when patients were analyzed according to the intention-to-treat principle, 15.0% of the patients in the angiography arm were actually treated with IVUS guidance whereas IVUS was not performed in 4.8% of the patients assigned to IVUS guidance. Therefore, when patients were analyzed according to how they were actually treated, IVUS guidance resulted in a statistically significant decrease in MACE from 8.1% to 4.0% (p = 0.048).. Although IVUS has been useful for evaluating lesion morphology and optimizing PCI procedures, especially in complex lesions, the beneficial role of IVUS guidance in routine clinical practice has been controversial. In the ...
Virtual histology intravascular ultrasound (VH-IVUS) is a clinically available technique for atherosclerosis plaque characterization. It, however, suffers from a poor longitudinal resolution due to electrocardiogram (ECG)-gated acquisition. This article presents an effective algorithm for IVUS image-based histology to overcome this limitation. After plaque area extraction within an input IVUS image, a textural analysis procedure consisting of feature extraction and classification steps is proposed. The pixels of the extracted plaque area excluding the shadow region were classified into one of the three plaque components of fibro-fatty (FF), calcification (CA) or necrotic core (NC) tissues. The average classification accuracy for pixel and region based validations is 75% and 87% respectively. Sensitivities (specificities) were 79% (85%) for CA, 81% (90%) for FF and 52% (82%) for NC. The kappa (k)50.61 and p value50.02 indicate good agreement of the proposed method withVHimages. Finally, the ...
A system and method are provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. In one embodiment, the computing device includes a plurality of applications operating thereon that are used to (I) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor.
Global Intravascular Ultrasound Devices Market by Manufacturers, Regions, Type and Application, Forecast to 2021Purchase This Report by calling ResearchnReports.com at +1-888-631-6977.. A research was lead in a prevalent period of time in the first half of the year in order to get information about the nature and growth of Intravascular Ultrasound Devices market. Data included in this report is cross-checked & referred to several other researches to validate them.. TO ensure that the data assembled is reliable, sources of information used are confirmed as legitimate and valid. The sources include Annual reports on the Intravascular Ultrasound Devices market, Government reports, global news, and business credit reports. Likewise there were interviews held with the customers, market experts and so forth. Insights from them were key in identifying and understanding the inner workings of the global Intravascular Ultrasound Devices market.. To assess the worldwide growth of the market, there was an ...
Previous angiographic natural history studies, such as CASS, demonstrated that patients with normal coronary arteries have a relatively benign prognosis. Like PROSPECT, CASS defined normal coronary arteries as having ,30% diameter stenosis by visual estimation (14,15). Glagov et al. (16) described the concept of compensated remodeling and concluded that compensation by vessel enlargement failed and luminal encroachment began when plaque accumulation (i.e., plaque burden) exceeded (on average) 40% of EEM area. Many plaque regression and progression studies have reported an average overall plaque burden in the study segments of approximately 40% (17,18). Many IVUS substudies of interventional trials have reported an average reference segment plaque burden of 40% (19). Again, this justifies the use of a plaque burden of 40% as the minimal threshold to define a lesion.. The minimal reported length of a pathologic TCFA is 1 to 2 mm (20-22). Antegrade or retrograde movement of an IVUS catheter ...
The current analysis by Zheng et al. (12), in this issue of iJACC, was to evaluate fibroatheroma characteristics predictive of the presence of plaque rupture-the relative importance of plaque burden, lesion location, and vessel area. Seventy-four ruptured and 2,396 nonruptured nonculprit lesion fibroatheromas were identified and classified as proximal, mid, or distal based on distance from the ostium. Most of the fibroatheromas were either in the proximal or mid segments. Independent predictors of plaque rupture were: distance from the ostium to the maximum necrotic core site, plaque burden, vessel area, presence of dense calcium, and RCA location. By receiver operating characteristic analysis, the strongest correlation with plaque rupture was vessel area. This correlated with plaque rupture more strongly than either plaque burden or location. Perhaps, as the authors suggest, greater external elastic membrane area is more predictive of plaque rupture because it incorporates the degree of plaque ...
Figure 1. Multimodal approach to atherosclerosis imaging. A representative illustration of current and emerging atherosclerosis imaging modalities. Each modality offers unique measurements of disease severity. Together, this information can be used to determine anatomic and hemodynamic consequences of atherosclerosis, complimented by detail on plaque composition, overall disease burden, and current metabolic activity acting within an individual patient. A, X-ray angiography showing multiple right coronary artery atherosclerotic lesions (arrows) resulting in significant luminal narrowing; B, virtual histology intravascular ultrasound (VH-IVUS) demonstrating coronary plaque with high content of necrotic core (red), as well as dense calcium (white) and fibro-fatty regions (dark/light green); C, Computed tomographic (CT) angiography showing noncalcified plaque in the left anterior descending artery with positive remodeling (dashed line); D, single-photon emission computed tomography (SPECT) ...
Intravascular ultrasound (IVUS) was used to visualize the extent of atherosclerotic plaques in the coronary artery lumen. Total atheroma volume (TAV) in a ≥ 40 mm segment of the targeted coronary artery was calculated as the average plaque area over the number of images that were evaluated by IVUS multiplied by the median vessel length to compensate for differences in segment length between participants.. Regression in TAV was defined as any reduction from baseline in TAV. ...
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Figure 1 Coronary Angiogram and Intravascular Ultrasound Images of the Left Coronary System. (A) Pre-procedural angiogram demonstrating a restenosed 3.5 × 15-mm Palmaz-Schatz stent (Cordis, Johnson & Johnson Company, Warren, New Jersey) (dotted line) implanted 20 years ago on the proximal LAD and a long segment of calcified disease extending from the LMS to the distal LAD, with involvement of the LAD/diagonal bifurcation (arrows). (B) Angiogram after rotational atherectomy with 1.5-mm burr and aggressive pre-dilation with 3.0- to 3.5-mm noncompliant balloons on LAD. A 2.25 × 12-mm EES in the diagonal ostium with crushed protruding EES struts (dotted line). (C) Intravascular ultrasound showing lumen area of 3.2 mm2 with a vessel diameter of 4.8 mm at the distal LMS. (D) Palmaz-Schatz stent struts (arrowheads) with evident dissection in the restenosed segment (arrows). (E) Cracked napkin-ring calcification after rotational atherectomy and pre-dilation (arrows). (F) Crushed EES struts on to the ...
IVUS imaging was performed after intracoronary administration of 0.2 mg nitroglycerin, using a motorized transducer pullback (0.5 mm/s) and a commercial scanner (Boston Scientific/SCIMED, Minneapolis, MN) consisting of a rotating 40-MHz transducer within a 3.2F imaging sheath. The decision to perform IVUS and the decision to use IVUS information to guide the percutaneous coronary intervention procedure was at the operators discretion.. All IVUS data were assessed off-line by experienced accessors unaware of the allocated stent type or clinical information in a core laboratory at the Asan Medical Center. Quantitative volumetric IVUS analysis was performed as previously described.8,9 Using computerized plannimetry (EchoPlaque 2.7, Indec Systems, Mountain View, CA), stent and reference segments were assessed every 1 mm. Reference segment external elastic membrane (EEM), lumen, and plaque+media (EEM minus lumen) areas were measured over a 5-mm length adjacent to each stent edge and averaged. ...
Aims: To compare the global characteristics of patients with and without evidence of plaque rupture (PR) in their coronary tree and to evaluate the phenotype of ruptured plaques using intravascular ultrasound (IVUS) radiofrequency data analysis (IVUS-VH). Methods and results: Forty patients underwent three-vessel IVUS-VH interrogation. Twenty-eight PRs were diagnosed in 26 vessels (25.7% of the vessels studied) of 20 patients (50% of the population). Ruptures located in the left anterior descending were clustered in the proximal part of the vessel, whereas ruptures located in the right coronary artery were more distally located (P=0.02). Patients with at least one PR presented larger body mass index (BMI) (28.4±3.7 vs. 25.8±2.6 kg/m 2, P=0.01) and plaque burden (40.7±7.6 vs. 33.7±8.4%, P=0.01) than patients without rupture, despite showing similar lumen cross-sectional area (9.6±3.3 vs. 9.2±2.3 mm 2, P=0.60). Among current smokers, 66.7% presented a PR in their coronary tree. Finally, PR ...
Microanatomy studies suggest most of penetrating arteries, which may be considered as flow dividers, arise dorsally from the upper part of MCA wall.5 In this study, plaques were observed predominantly in the ventral and inferior wall, the locations opposite to the orifices of penetrating arteries. Therefore, MCA plaque distribution appears following the same rule as coronary atherosclerosis.1 These findings are meaningful. A major concern of intracranial angioplasty has been the forceful displacement of neighboring atheromatous material into branch vessel ostia. The opposite location of most MCA plaques and penetrating artery orifices suggests that such snow-plowing effect in intracranial angioplasty might be uncommon. Previous studies have indicated that the incidence of side branch occlusion after MCA stenting is indeed very low.6. Our study also revealed that symptomatic MCA stenosis had more superior but less inferior plaque location than asymptomatic stenosis. The occurrence of ...
TY - JOUR. T1 - Exercise echocardiography, angioqraphy, and intracoronary ultrasound after cardiac transplantation. AU - Cohn, Joel M.. AU - Wilensky, Robert L.. AU - ODonnell, Jacqueline A.. AU - Bourdillon, Patrick D.V.. AU - Dillon, James C.. AU - Feigenbaum, Harvey. PY - 1996/6/1. Y1 - 1996/6/1. N2 - Fifty-one consecutive patients underwent exercise echocardiography, angiography, and intracoronary ultrasound (ICUS) 2.5 years (range 1 to 6) after cardiac transplantation. The average age of the donor was 29 years (range 13 to 50), and the average age of the recipient was 49 ± 12 years. In total, 78 studies were performed, as 25 patients had , 1 annual evaluation and 2 patients had 3 consecutive annual evaluations. Of the 78 angiographic studies, 40 (26 patients) had evidence of coronary artery disease, defined as a focal stenosis (,20%, n = 4) or luminal irregularities (n = 36). However, by ICUS all 51 patients had intimai thickening at some point, with 34 patients possessing diffuse disease ...
Coronary intravascular ultrasound (IVUS): Coronary intravascular ultrasound (IVUS) uses small catheters with ultrasound transducers at the tip to image the coronary arteries with ultrasound from within the lumen. The special catheters can be introduced through a guide catheter into the main coronary arteries. They are then connected to the the ultrasound equipment kept in the console. Imaging is done as the catheter is pulled back and recorded. It is very useful to detect abnormalities in the vessel wall which can be missed by conventional coronary angiography. When a coronary stent has been implanted, IVUS imaging is very helpful to check whether all parts of the stent has been well apposed to the vessel wall.. ...
Intravascular Ultrasound Tools Market This report studies Intravascular Ultrasound Tools in Global market, especially in North America, Europe, China, Ja
Intravascular Ultrasound 1991 by W. J. Gussenhoven available in Trade Paperback on Powells.com, also read synopsis and reviews. The introduction of intravascular ultrasound has attracted considerable interest because it yields...
There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS). A total of 298 consecutive patients who received percutaneous coronary interventions under IVUS guidance were retrospectively enrolled. The value of HOMA-IR more than 2.5 was considered as IR positive. Metabolic syndrome was classified according to NCEP ATP III guidelines. The remodeling index was defined as the ratio of the external elastic membrane (EEM) area at the lesion site to the EEM area at the proximal reference site. A total of 369 lesions were analyzed (161 lesions in HOMA-IR positive and 208 lesions in HOMA-IR negative). Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074
Intravascular ultrasound techniques provide for intravascular imaging using contrast agents and nonlinear techniques. An ultrasound imaging device for detecting internal properties of a target body comprises an ultrasound transducer positioned at a distal end portion of a catheter, for transmitting excitation pulses and for receiving echo signals. A signal processor analyses echo signals at harmonics and/or subharmonics of the transmit frequency. The catheter may include a contrast agent delivery conduit extending along the catheter, the delivery conduit having an exit orifice proximal to the ultrasound transducer. The device may discriminate between echo signals respectively arising from interaction with tissue and from the interaction with contrast agent. The device may generate an image of the site of interest using non-linear components of the received ultrasound echo signals.
High-density lipoprotein cholesterol increased 5.8 mg/dl versus 1.8 mg/dl (p < 0.001), high-sensitivity C-reactive protein decreased 1.3 mg/dl versus 0.9 mg/dl (p < 0.001), and glycated hemoglobin increased 0.11% versus 0.40% (p < 0.001), respectively, for rimonabant versus control. There was no change in low-density lipoprotein cholesterol: 1.7% versus 0.44% (p = 0.78), respectively ...
Sonographic guidance for interventional procedures offers several advantages: it is less expensive, quicker, available in real time, avoids ionizing radiation, and is portable. However, a learning cur... more
Background: Despite the successful development in cardiac surgery, cerebrovascular accidents (CVA) remain a devastating complication. Aortic atherosclerosis has been identified as a major risk factor for CVA. The present thesis addresses this question in relation to aortic manipulation during cardiac surgery, being divided into a clinical (I-II) and an experimental part (III-V).. Material and methods: Consecutive cardiac surgery cases (n=2641) were analyzed. Patients with CVA were extracted from a database designed to monitor clinical symptoms. Patient records were used to confirm clinical data and diagnosis. Subdivision was made into three groups: control subjects, immediate, and delayed CVA, being analyzed for neurological symptoms (I). Patients with CVA who also had been investigated with computer tomography (CT) (n=77) were further evaluated in terms of hemispheric and vascular distribution of lesions. The CT-findings were compared with CVA symptoms (II). An aortic perfusion model was ...
Target coronary artery for IVUS must be accessible to the IVUS catheter, must not have a , 50% reduction in lumen diameter within the target segment (and at least 40 mm in length); cannot have undergone prior PCI or coronary artery bypass graft (CABG) and is not a candidate for intervention over the next 18 months. It may not be a bypass graft, bypassed vessel or culprit vessel for previous myocardial infarction (MI ...
A new study found that intravascular ultrasound (IVUS)-guided intervention in patients with chronic total occlusion (CTO) could improve outcomes compared to a conventional angiography-guided approach during percutaneous coronary intervention. The IVUS-CTO study is the first randomized trial to examine the clinical impact of IVUS guidance for CTO intervention.
OBJECTIVE: To report a novel technique of ultrasound-guided injection of autologous blood in the interprostatorectal space, in an attempt to facilitate ablative prostatic procedures by widening durably the space between the rectum and the prostate. MATERIALS AND METHODS: Between April and November 2016, four consecutive patients underwent the haemoprotection injection technique. For each patient, we recorded the time to perform the technique, the amount of injected blood, the achieved distances between the rectum and the prostate post-injection at fixed defined points (apex, middle, and base of prostate at the midline, left, and right sides of the gland), the extension of the ice ball outside the prostate capsule at those fixed points, and whether any residual blood was present on 1-month follow-up MRI ...
Perform ultrasound-guided injections for research animals using Vevo micro-ultrasound imaging systems. Visualize your target without the need for surgical intervention.
We appreciate the opportunity to respond to comments by Gutierrez and Elkind1 about our recent article.2 We think that they misunderstood our imaging-based methodology and would like to offer reasons that might explain their discrepant results.3. The authors assert that plaque burden should be based on intimal area when determining the remodeling threshold. Our definition has been used in other published magnetic resonance imaging and intravascular ultrasound studies that demonstrate remodeling justifiably because atherosclerotic changes can extend beyond the internal elastic lamina. Furthermore, colinearity did not influence our results as suggested by Gutierrez and Elkind1 because we defined stenosis based on lumen reduction, unlike the definition used in pathological specimen studies.3,4 About the slope of the regression line, S is simply a variable that can be negative or positive depending on whether the vessel tapers or, uncommonly, enlarges from proximal to distal locations. Others have ...
Fig. 8. (A) Angioscopic image of the left anterior descending artery in a patient with acute MI demonstrating yellow plaque. (B,C,D) Intravascular ultrasound images as depicted in lesion A demonstrating compensatory enlargement. (B) At the defined proximal reference site the external elastic membrane (EEM) cross-sectional area (CSA) was 11.8 mm2. (C) At the culprit lesion, EEM CSA was 13.5 mm2. (D) At the distal reference site, EEM CSA was 9.6 mm2. The remodeling ratio (RR) was 1.26. (E) Angioscopic image of the left anterior descending artery in a patient with stable angina demonstrating white plaque. (F,G,H) Intravascular ultrasound images at the same lesion as E demonstrating paradoxical shrinkage. (F) At the proximal reference site, EEM CSA was 17.1 mm2. (G) At the culprit lesion EEM CSA was 10.1 mm2. (H) At the distal reference site, EEM CSA was 15.3 mm2. The RR was 0.62 (79).. Fig. 8. (A) Angioscopic image of the left anterior descending artery in a patient with acute MI demonstrating ...
TY - JOUR. T1 - Percutaneous transhepatic portography with intravascular ultrasonography for evaluation of venous involvement of hepatobiliary and pancreatic tumors. AU - Stein, Moni. AU - Schneider, Philip D. AU - Ho, Hung S. AU - Eckert, Robin. AU - Urayama, Shiro. AU - Bold, Richard J. PY - 2002. Y1 - 2002. N2 - PURPOSE: To determine the safety and utility of percutaneous transhepatic portography (PTP) with intravascular ultrasonography (IVUS) for preoperative evaluation of major spleno-mesenteric-portal venous invasion by tumors of the pancreas, porta hepatis, or liver. MATERIALS AND METHODS: This is a 2-year prospective observational study including 15 consecutive patients (five men, 10 women; mean age, 63.3 ± 10.2) with tumors of the pancreas (n = 8), liver (n = 3), or porta hepatis (n = 4) who underwent PTP/IVUS after computed tomography indicated possible tumor invasion into a major portal radical. Transhepatic portal access was created under fluoroscopic guidance with an 8-F vascular ...
TY - JOUR. T1 - Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents. T2 - Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial. AU - Tanabe, Kengo. AU - Serruys, Patrick W.. AU - Degertekin, Muzaffer. AU - Guagliumi, Giulio. AU - Grube, Eberhard. AU - Chan, Charles. AU - Munzel, Thomas. AU - Belardi, Jorge. AU - Ruzyllo, Witold. AU - Bilodeau, Luc. AU - Kelbaek, Henning. AU - Ormiston, John. AU - Dawkins, Keith. AU - Roy, Louis. AU - Strauss, Bradley H.. AU - Disco, Clemens. AU - Koglin, Jörg. AU - Russell, Mary E.. AU - Colombo, Antonio. PY - 2004/1/20. Y1 - 2004/1/20. N2 - Background-Polymer-controlled paclitaxel-eluting stents have shown a pronounced reduction in neointimal hyperplasia compared with bare metal stents (BMS). The aim of this substudy was to evaluate local arterial responses through the use of serial quantitative intravascular ultrasound (IVUS) analyses in the TAXUS II trial. Methods and ...
BACKGROUND: Prospective data on the associations of adiponectin with in-vivo measurements of degree, phenotype and vulnerability of coronary atherosclerosis are currently lacking.OBJECTIVE: To investigate the association of plasma adiponectin with virtual histology intravascular ultrasound (VH-IVUS)-derived measures of atherosclerosis and with major adverse cardiac events (MACE) in patients with established coronary artery disease.METHODS: In 2008-2011, VH-IVUS of a non-culprit non-stenotic coronary segment was performed in 581 patients undergoing coronary angiography for acute coronary syndrome (ACS, n = 318) or stable angina pectoris (SAP, n = 263) from the atherosclerosis-intravascular ultrasound (ATHEROREMO-IVUS) study. Blood was sampled prior to coronary angiography. Coronary plaque burden, tissue composition, high-risk lesions, including VH-IVUS-derived thin-cap fibroatheroma (TCFA), were assessed. All-cause mortality, ACS, unplanned coronary revascularization were registered during a ...
Study Objectives: We assessed whether excessive daytime sleepiness was associated with coronary plaque phenotype and subsequent adverse cardiovascular events. Methods: Prospective cohort study. Intravascular ultrasound (IVUS) examination of the culprit coronary stenosis was performed. The Epworth Sleepiness Scale (ESS) questionnaire was administered, and the patients were divided into 2 groups - (1) sleepier and (2) less sleepy - based on the ESS score. Adverse cardiovascular outcomes were defined as cardiac death, myocardial infarction, stroke, unplanned revascularization, or heart failure admission. Results: One hundred seventeen patients undergoing urgent or non-urgent coronary angiography were recruited. Compared with the less sleepy group (ESS ≤ 10, n = 87), the sleepier group (ESS > 10, n = 30) had higher serum levels of total cholesterol and of low-density-lipoprotein cholesterols (p < 0.05 for both). The IVUS examinations indicated coronary stenoses were longer in the sleepier group ...
TY - JOUR. T1 - Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities. AU - Al-Mallah, Mouaz. AU - Sinno, Mohamad C.N.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010. Y1 - 2010. N2 - Atherosclerosis is a systemic disease that affects most vascular beds. The gold standard of atherosclerosis imaging has been invasive intravascular ultrasound (IVUS). Newer noninvasive imaging modalities like B-mode ultrasound, cardiac computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI) have been used to assess these vascular territories with high accuracy and reproducibility. These imaging modalities have lately been used for the assessment of the atherosclerotic plaque and the response of its volume to several medical therapies used in the treatment of patients with cardiovascular disease. To study the impact of these medications on atheroma volume progression or regression, imaging ...
This report analyzes the worldwide markets for Intravascular Ultrasound (IVUS) in US$ Thousands by the following Product Segments: Intravascular Ultrasound
- Experimental fetal transesophageal and intracardiac echocardiography utilizing intravascular ultrasound technology. - Swissfetus
Prevention of unnecessary arthrocentesis is possible through confirmation of the effusion with ultrasonography (US). Procedural success is increased, and potential damage to important structures (vess... more
The Visions PV .014P RX digital IVUS catheter has a 55% stiffer shaft than Eagle Eye Platinum and PV .014P digital IVUS catheters to facilitate greater pushability while preserving the equivalent level of trackability.¹
A peripheral blood gene expression score is associated with plaque volume and phenotype by intravascular ultrasound with radiofrequency backscatter analysis: results from the ATLANTA study
van der Sijde, Johannes N; Karanasos, Antonios; van Ditzhuijzen, Nienke S; Okamura, Takayuki; van Geuns, Robert-Jan; Valgimigli, Marco; Ligthart, Jurgen M R; Witberg, Karen T; Wemelsfelder, Saskia; Fam, Jiang Ming; Zhang, BuChun; Diletti, Roberto; de Jaegere, Peter P; van Mieghem, Nicolas M; van Soest, Gijs; Zijlstra, Felix; van Domburg, Ron T; Regar, Evelyn (2017). Safety of Optical Coherence Tomography in Daily Practice a Comparison with Intravascular Ultrasound. European Heart Journal. Cardiovascular Imaging, 18(4):467-474. ...
The Brady MRO Plus Medium Weight Industrial Absorbent Pad Roll can be used to keep fluid spills clean in a work area and last a long time.
An ultrasound system has an ultrasound transducer having a transducer housing and a horn provided at the distal end of the transducer housing, an ultrasound transmission member, a sonic connector that is connected to the horn and the proximal end of the ultrasound transmission member, and a catheter knob having a proximal end that is coupled to the distal end of the transducer housing. The catheter knob has a proximal bore that houses the sonic connector. The system also includes a nesting piece that is retained inside the proximal bore of the catheter knob. The nesting piece can be moved from a first position where the sonic connector is received inside the nesting piece to a second position where the sonic connector is separated from the nesting piece when ultrasound energy is being propagated through the ultrasound transmission member.
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TCTMD is produced by the Cardiovascular Research Foundation (CRF). CRF is committed to igniting the next wave of innovation in research and education that will help doctors save and improve the quality of their patients lives. For more information, visit http://www.crf.org.. ...
The Eagle Eye Platinum digital IVUS catheter provides plug-and-play simplicity only offered by Philips Volcano, with the unique ability to view grayscale, VH IVUS, or ChromaFlo images, in the coronary or peripheral vasculature.
The Visions PV .018 digital IVUS catheter provides vessel imaging, an essential approach for the diagnosis and treatment of coronary and peripheral vasculature.
TY - JOUR. T1 - Intraluminal Ultrasound Assessment of Vascular Stent Deployment. AU - Cavaye, Douglas M.. AU - Tabbara, Marwan R.. AU - Kopchok, George E.. AU - Termin, Paul. AU - White, Rodney A.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - This study assessed the utility of intraluminal ultrasound imaging during deployment of a self-expanding vascular stent and quantitated changes in arterial morphology produced by the stent. Cross-sectional images of arterial lumens (n=50) were obtained before stenting, in-vitro (n=35) from formalin-preserved human superficial femoral arteries and in-vivo (n=15) from canine iliac arteries containing laser-induced eccentric stenoses. Comparison of ultrasound-derived vessel dimensions (minimum and maximum diameter and cross-sectional area) with histological morphometric analysis of corresponding vessel sites showed good correlation by linear regression analysis (r=0.930-0.987, p=0.001-0.005). Following stent placement, 23 intraluminal ultrasound images were obtained ...
The investigators hypothesis is that local activation of the endogenous Lp-PLA2 plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and mechanical properties that characterize plaque vulnerability. Thus, our study will characterize prospectively the correlation between the functional and structural vascular wall properties, and the activity of the Lp-PLA2 pathway.. ...
Interventional biopsy and image guided injections is a medical test to identify the cause of a lump or mass, or other abnormal condition in the body.
A. Ramasamy, J. Ng, S. White, TW. Johnson, N. Foin, et al. MJA. Girard, J. Dijkstra, R. Amersey, S. Scoltock, S. Koganti, D. Jones, C. Jin, L. Räber, PW. Serruys, R. Torii, T. Crake, R. Rakhit, A. Baumbach, A. Mathur, CV. Bourantas. (2019). Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments - An In Vivo and Histology-Based Study. Circulation Journal. G. Suna, W. Wojakowski, M. Lynch, J. Barallobre-Barreiro, X. Yin, et al. U. Mayr, F. Baig, R. Lu, M. Fava, R. Hayward, C. Molenaar, SJ. White, T. Roleder, K. Milewski, P. Gasior, PP. Buszman, PE. Buszman, M. Jahangiri, C. Shanahan, JM. Hill, M. Mayr. (2017). Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 137(2), pp.166-183. MC. Smith, C. Hudson, S. White, T. Kimura, G. Sala-Newby, et al. A. Newby, M. Bond. (2017). Camp ...
With intracoronary IVUS, a catheter is inserted into a coronary artery where high-frequency sound waves reflect off tissue or vessel walls. The reflected sound waves create a cross-sectional image from within the vessel to aid in visualising vessel structure. IVUS technology provides physicians with a better understanding of atherosclerotic vessels, supporting appropriate treatment strategy, stent selection, stent placement and adequate deployment to restore blood flow at the target site ...
Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.
MesenCult™-ACF Plus, a serum- and animal component-free medium for the derivation and expansion of human mesenchymal stromal cells (MSCs).
Enriched Serum-free/low protein medium without insulin,trasferrin,hormones,or other growth factors.Formulated for the growth and maintenance of a wide varietyof hybridomas, as well as suspension and adherent cell lines. ...
The first issue is the period of time the patient has had vascular disease. Anatomical factors which influence restenosis outcomes assessment include; occlusion vs. stenosis, inflow/run-off status, vessel diameter and atheroma volume. In addition, patient factors such as gender, diabetes and history of smoking must be understood and consequently analysed, Gray said.. There are also challenges to understand and overcome in developing an effective device platform. For example, Grey cited the nitinol stent and whether this should be a slotted tube or spiral design. In addition, he said that the rate of stent fracture in self-expanding platforms was not fully understood. Finally, Grey said that clinicians also faced challenges in data collection such as endpoint definitions of success and the effectiveness of discrete vs diffuse vs volume definitions. There were also issue surrounding quantifying and understanding restenosis (angiographic, Duplex, intravascular ultrasound). This is compounded by the ...
Comprehensive Atlas of Ultrasound-Guided Pain Management Injection Techniques depicts in crisp, step-by-step detail how to prepare and perform injections under ultrasound guidance. Over 160 ultrasound-guided injection techniques are depicted in short, easy to review chapters with hundreds of full color photographs and illustrations. The accompanying website presents many of these techniques in video. Coverage includes techniques for head, neck, shoulder, elbow and forearm, wrist and hand, chest wall, trunk and abdomen, low back, hip and pelvis, knee and lower extremity, and foot and ankle ...
Researchr is a web site for finding, collecting, sharing, and reviewing scientific publications, for researchers by researchers.. Sign up for an account to create a profile with publication list, tag and review your related work, and share bibliographies with your co-authors. ...
Image fusion enables us to perform a direct, on-screen correlation between a current ultrasound study and a previously performed CT or MRI exam. Using this ability, the spatial resolution of the ultrasound image can be added to the superior overview of a CT or MRI providing additional clinical confidence, lesions first noted on CT or MRI may be more easily detected and characterised on ultrasound and interventions such as biopsies and tumour ablations may be guided by a combination of modalities. Participants in this symposium will become familiar with how image fusion adds another dimension both to diagnostic and interventional ultrasound.. ...
Intravascular ultrasound (IVUS) is the most favorable imaging modality that often used in coronary artery catheterization procedures and provides cross-sectional images of arterial wall structures and extend of atherosclerosis disease. Although several techniques have been developed to classify atherosclerotic tissues, deploying IVUS radiofrequency (RF) backscattered signals and/or grayscale images their clinical applications have seen limited success. In this paper, we propose a unified methodological framework from data collection, histology preparation, registration, feature extraction, and classification to achieve a reliable in vitro trained tissue characterization classifier for in vivo applications. Finally, the results from proposed algorithm is compared with state of the art virtual histology (VH) technique ...
If the ipsilateral CIV is all compressed, we do the sizing based on the contralateral noncompressed CIV using the same method. Another method we have successfully used is to measure the ipsilateral CIV reference area by intravascular ultrasound (IVUS) and determine the matching theoretical diameter of a circle (Table 1). The stent is then chosen with 1 to 2 mm larger diameter than the theoretical diameter obtained. Measuring the stent size based on computed tomography angiography (CTA) prior to the procedure to predict the stent to be used is likely to overestimate the size of the stent, as minimal luminal area obtained by CTA seems to be higher than what is measured by IVUS.4 The sizing methods above intend to obtain full apposition of the stent to the reference vessel. However, prestenotic dilation could lead to oversizing of the stent. It is unknown at this time whether oversizing can lead to adverse consequences. Reports indicate that pain in the low back may become more exaggerated post ...
The Visions PV .014P RX digital IVUS catheter has a 55% stiffer shaft than Eagle Eye Platinum and PV .014P digital IVUS catheters to facilitate greater pushability while preserving the equivalent level of trackability.¹