Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
A novel series of tubulin polymerization inhibitors, based on fluorinated derivatives of isocombretastatin A-4 was synthesized with the goal of evaluating the effect of these compounds on the proliferative activity. The introduction of fluorine atom was performed on the phenyl ring or at the linker between the two aromatic rings. The modification of isoCA-4 by introduction of difluoromethoxy group at the para-position (3i) and substitution of the two protons of the linker by two fluorine atoms (3m), produced the most active compounds in the series, with IC50 values of 0.15-2.2 nM (3i) and 0.1-2 nM (3m) respectively, against a panel of six cancer cell lines. Compounds 3i and 3m had greater antiproliferative activity in comparison with references CA-4 or isoCA-4, the presence of fluorine group leads to a significant enhancement of the antiproliferative activity. Molecular docking studies indicated that compounds 3i and 3m occupy the colchicine binding site of tubulin. Evaluation of cytotoxicity in ...
TY - JOUR. T1 - Identification of a class of novel tubulin inhibitors. AU - Yi, Xin. AU - Zhong, Bo. AU - Smith, Kerri M.. AU - Geldenhuys, Werner J.. AU - Feng, Ye. AU - Pink, John J.. AU - Dowlati, Afshin. AU - Xu, Yan. AU - Zhou, Aimin. AU - Su, Bin. PY - 2012/4/12. Y1 - 2012/4/12. N2 - We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. However, the molecular targets of these agents still remain unclear. In this study, we synthesized a biotinylated probe based on a representative molecule of the compound library and performed protein pull-down assays to purify the anticancer targets of the compound. Via proteomic approaches, the major proteins bound to the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibited tubulin polymerization by binding at the colchicine domain. However, the tubulin inhibitory effect of the compound activated the Hsp27 phosphorylation and possibly ...
Interfering with microtubule dynamics is a validated approach for anticancer treatment and by selectively targeting the colchicine binding site on tubulin, microtubule destabilizing agents can evade mechanisms of drug resistance that commonly develop with other antimitotic agents such as taxanes and vinca alkaloids. We have recently reported the discovery of a potent and metabolically stable tubulin inhibitor (DJ101) that specifically targets the colchicine binding site on the beta tubulin subunit, disrupts tubulin polymerization and effectively circumvents drug efflux pumps that decrease the efficacy of existing tubulin inhibitors. To further pre-clinically evaluate DJ101 as a novel tubulin inhibitor and confirm its mechanism of action, we first visually demonstrated the ability of DJ101 to disrupt microtubule dynamics and elucidated the changes in microtubule structure and cell morphology through immunofluorescence techniques. Furthermore, we solved the crystal structure of DJ101 in complex ...
Acute myeloid leukemia (AML) is a hematological malignant disorder. AML cells are not susceptible to chemotherapeutic drugs because of their multidrug resistance (MDR). Antitubulin agents are...
Most of the ADCs currently in the market and in clinical development carry tubulin polymerization inhibitors such as T-DM1 and SGN-35 (Brentuximab vedotin; ref. 13). We synthesized a novel ADC with a topoisomerase I inhibitor, which has a different mechanism of action from tubulin polymerization inhibitors, and a novel self-immolative linker system using an aminomethylene (AM) moiety. Although other cleavable linker systems applied to SGN-35 (Brentuximab vedotin) and several ADCs release amino group-containing payloads, this AM self-immolative linker system is able to release DXd containing the hydroxyl group from DS-8201a. Moreover, this novel linker-payload system enables a reduction in the hydrophobicity of the ADC and helps increase its DAR. In the case of T-DM1, lysine conjugation and noncleavable systems are used, and it is quite a different system from DS-8201a. DS-8201a showed potent HER2-specific efficacy both in vitro and in vivo, and by drug conjugation maintained the functional ...
The process of producing styrene comprising the use of a solution of paranitrosophenol in n-methyl pyrollidone as a polymerization inhibitor during said process. A polymerization inhibitor system for monomers comprising a solution of a polymerization inhibitor in a solvent which is miscible with the feedstock for the monomer and the monomer. Dinitro-orthocresol works very well, but is extremely toxic. NAUGARD® SFR inhibitor by SI Group is a sterically hindered nitroxyl stable free radical. According to the report findings, the certificate of inhibitor, issued by the cargo surveyor at the time of loading, stated that the TBC should remain effective for between 60 and 90 days. It can be used when storing highly reactive monomers. TISP is based on the new principles of Inhibition. Specialty Chemicals HP. AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO ...
4SC-207 is a novel microtubule inhibitor, which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.
Lexibulin, also known as CYT997, is a n orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for active clinical trials or closed clinical trials using this agent.
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We hypothesized that the effects of Centrin2 inactivation could be associated with transient microtubule disruption. In support of this idea, we found that the treatment of freshly isolated E16 mouse neurons with the microtubule-destabilizing agent nocodazole (6 μm, 2 h) lead to disruption of the cytoplasmic polarity, as evidenced by the dispersion of the Golgi apparatus and late endosomes (see supplemental Fig. 3C,D, available at www.jneurosci.org as supplemental material) (n = 90 cells from 3 brains) as well as neurite retraction (data not shown) (de Anda et al., 2005). To confirm the specificity of the Centrin2 inactivation using CALI, we imaged neurons in irradiated slices that did not express the Centrin2-KR and found normal neuronal differentiation with the polarized cytoplasm oriented toward the medial/apical neurite (Fig. 3C,D) (8 h) that would become the axon (Fig. 3D, 42 h, black arrowheads and Inset 1) (for the whole time-lapse sequence and detailed z-stack analysis of the L1 ...
PharmaMar announced that its novel Antibody-Drug Conjugate (ADC) demonstrates strong anticancer activity in vitro and in vivo against tumors expressing HER2 derived from breast, gastric and ovarian cancers. The novel ADC MI130004 consists of a new marine-derived tubulin inhibitor that is covalently bound to the HER2 antibody trastuzumab via a non-hydrolysable linker.
Anticancer activity of a novel small molecule tubulin inhibitor STK899704 / K Sakchaisri; Sun Ok Kim; Joonsung Hwang; Nak Kyun Soung; Kyung Ho Lee; Tae Woong Choi; Yongjun Lee; Chan-Mi Park; N R Thimmegowda; Phil Young Lee; B Shwetha; G Srinivasrao; T T H Pham; Jae-Hyuk Jang; H W Yum; Y J Surh; K S Lee; H Park; Seung Jun Kim; Y T Kwon; Jong Seog Ahn; Bo Yeon Kim , 2017 ...
A better understanding of the target requirements is needed for optimal intracellular delivery of cytotoxic agents by antibody-drug conjugates (ADCs). de Goeij and colleagues compared the efficacy of ADCs targeting tissue factor (TF), HER2 and EGFR, with the target characteristics required for an ADC approach. Unlike HER2 and EGFR, TF was constitutively being internalized and degraded in tumor cells. When conjugated with the tubulin inhibitor duostatin-3, TF-ADC was relatively potent in reducing tumor growth compared with EGFR- and HER2-ADCs. It was found that the high turnover of TF on tumor cells might be the reason why this protein is specifically suitable for an ADC approach. ...
Sulfo-PDBA-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody drug conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker. - Mechanism of Action & Protocol.
We showed that vinflunine previously, a microtubule-targeting medication of the and assays. produced with Metamorph software program?. Transwells HUVECs or U87 (50.000 per condition) were put on the upper side of a transwell migration chamber (0.8 m filter, BD) Matrine in serum free moderate. The smaller part of the holding chamber was stuffed with tradition moderate finished with VEGF (10 ng/ml) for migration of HUVECs or regular tradition moderate for U87 cells. Cells were allowed to transmigrate for 5 l and chambers were removed in that case. Cells PRPH2 that do not really migrate remained on the upper part of the filter and were removed with a cotton stick; cells on the lower side of the filter were fixed with 1% glutaraldehyde (Sigma- Aldrich) and stained with 1% Crystal-violet solution in 20% methanol. After washing and drying, pictures of four fields per filter were taken at a magnification of 10. Quantification of cell transmigration was made with Metamorph software Matrine ? and results ...
The stilbenic compound (Z)-combretastatin A-4 (CA-4) has been described as a potent tubulin polymerization inhibitor. In vivo, CA-4 binds to tubulin and inhibits microtubule depolymerization, which results in morphological changes in proliferating endothelial cells. Combretastatin A-4 prodrug phosphate is a leading vascular disrupting agent and is currently being evaluated in multiple clinical trials as a treatment for solid tumors. The aim of this study was to identify and characterize the UDP-glucuronosyltransferase (UGT) isoforms involved in CA-4 glucuronidation by incubation with human liver microsomes and a panel of nine liver-expressed recombinant UGT Supersomes (1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B15, and 2B17). As we observed, the high rate of formation of CA-4 glucuronide (Vmax = 12.78 ± 0.29 nmol/min/mg protein) and the low Km (6.98 ± 0.65 μM) denoted that UGT1A9 was primarily responsible for the in vitro glucuronidation of CA-4. UGT1A6 was also a significant contributor to CA-4 ...
The stilbenic compound (Z)-combretastatin A-4 (CA-4) has been described as a potent tubulin polymerization inhibitor. In vivo, CA-4 binds to tubulin and inhibits microtubule depolymerization, which results in morphological changes in proliferating endothelial cells. Combretastatin A-4 prodrug phosphate is a leading vascular disrupting agent and is currently being evaluated in multiple clinical trials as a treatment for solid tumors. The aim of this study was to identify and characterize the UDP-glucuronosyltransferase (UGT) isoforms involved in CA-4 glucuronidation by incubation with human liver microsomes and a panel of nine liver-expressed recombinant UGT Supersomes (1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B15, and 2B17). As we observed, the high rate of formation of CA-4 glucuronide (Vmax = 12.78 ± 0.29 nmol/min/mg protein) and the low Km (6.98 ± 0.65 μM) denoted that UGT1A9 was primarily responsible for the in vitro glucuronidation of CA-4. UGT1A6 was also a significant contributor to CA-4 ...
Endothelial tubular morphogenesis relies on an exquisite interplay of microtubule dynamics and actin remodeling to propel directed cell migration. Recently, the dynamicity and integrity of microtubules have been implicated in the trafficking and efficient translation of the mRNA for HIF-1α (hypoxia-inducible factor), the master regulator of tumor angiogenesis. Thus, microtubule-disrupting agents that perturb the HIF-1α axis and neovascularization cascade are attractive anticancer drug candidates. Here we show that EM011 (9-bromonoscapine), a microtubule-modulating agent, inhibits a spectrum of angiogenic events by interfering with endothelial cell invasion, migration and proliferation. Employing green-fluorescent transgenic zebrafish, we found that EM011 not only inhibited vasculogenesis but also disrupted preexisting vasculature. Mechanistically, EM011 caused proteasome-dependent, VHL-independent HIF-1α degradation and repressed expression of HIF-1α downstream targets, namely VEGF and ...
Epothilones are a novel class of microtubule-targeting anticancer agents that are neurotoxic. In this study, we investigated the epothilone B toxic effect in vitro and we characterized in vivo the general and neurological side effects of epothilone B administration in Wistar and Fischer rats. The in vitro experiments made it possible to explore a wide concentration range (0.1 nM-1 muM) and evidenced a dose-dependent effect of epothilone B exposure on neuron neurite elongation. This dose-dependent neurotoxic effect was confirmed in both in vivo studies performed on two different rat strains at the neurophysiological, behavioral and pathological levels in the dose range 0.25-1.5 mg/kg iv weekly x 4 weeks and tubulin hyper-polymerization was demonstrated in sciatic nerve specimens. These are the first studies of the neurological effects of epothilone B and they can provide a basis for extending pre-clinical investigation to other members of the epothilone family.
PAB is a diterpenoid isolated from the root bark of Pseudolarix kaempferi Gordon tree (Pinaceae). Previous findings indicate that it possesses potent antifungal and cytotoxic activities as well as pregnancy-terminating effects (28 , 32) , in which angiogenesis is involved. In this study, we first demonstrated the antiangiogenic ability of PAB by effectively suppressing in vitro proliferation, migration, and tube formation of HUVECs. Moreover, the CAM assay, in which PAB repressed the in vivo angiogenesis, validated the in vitro results. Additionally, another study in our laboratory discovered that the inhibition of PAB on tubulin polymerization in endothelial cells was distinct from other known tubulin inhibitors such as colchicine, vincristine, and taxol.4 These results indicate that PAB can directly inhibit the angiogenesis potential of human endothelial cells.. Interestingly, we have additionally found that PAB could also reduce the stimulator VEGF secretion and its corresponding mRNA level ...
Join Lenka Munoz of the Faculty of Medicine and Health at the University of Sydney and Patrick Sexton, from the University of Melbourne as she provides novel insights into the relationship between the tubulin code and MTA efficacy as well as discusses the role of cancer cell dormancy in the sensitivity of cancer cells to MTA.
Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and ...
Recent drug discovery studies have focused on the design and synthesis of small molecules that have a 1H-indazole nucleus as the core structure and that act as tubulin inhibitors [1]. Drugs that bind to tubulin act by interfering with the mitosis of cells during the M-phase, resulting in mitotic arrest and eventually lead in to apoptosis [2]. Therefore, microtubules are a sensitive target for the development of anticancer drugs. Due to the introduction of vinca alkaloids such as vincristine and vinblastine for the clinical therapy of cancer, 1H-indazole carrying compounds have generated considerable interest [3-8]. A large numbers of synthetic 1H-indazole-containing drugs and clinical candidates have been identified over the past few years Chang and co-workers reported a large number of compounds with 1H-indazole core structure. In addition to the synthesis and evaluation of the anticancer activity of these compounds, they have revealed some SAR and pharmacophore modeling data [4,5,9-13]. ...
Biological Description: Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.IC50 Value:Target: Microtubule/Tubulinin vitro: BMS-247550 (EpoB), a novel epothilone B ...
Glioblastoma patients have limited treatment options. Cancer stem-like cells (CSLC) contribute to glioblastoma invasiveness and repopulation; hence, they represent promising targets for novel therapies. BAL101553 is a prodrug of BAL27862, a novel microtubule-destabilizing agent inhibiting tumor cell proliferation through activation of the spindle assembly checkpoint, which is currently in phase I/II clinical development. Broad anticancer activity has been demonstrated against human cancer models, including tumors refractory to conventional treatments. We have shown that overexpression of microtubule + end-binding 1-protein (EB1) correlates with glioblastoma progression and poor survival. Here, we show that BAL27862 inhibits the growth of two glioblastoma CSLCs. As EB1 is overexpressed in the CSLC line GBM6, which displays a high tumorigenicity and infiltrative pattern of migration in vivo, we investigated drug activity on GBM6 according to EB1 expression. BAL27862 inhibited migration and colony ...
This study presents the biological validations of the rational synthesis of pyrrole-containing colchicine site agents based on our refined colchicine binding site model, docking and 3D QSAR methodologies. With this refined binding model, we designed molecules that, as predicted, bind more optimally within the colchicine domain and have superior biological potencies and specificity as compared with earlier generation pyrrole-based colchicine site agents. In particular, the 2,3,4 trimethoxyphenyl analog, NT-7-16, showed excellent, low nanomolar potency in a variety of sensitive and drug resistant cancer cell lines, was more potent than CA-4 in its ability to inhibit the polymerization purified tubulin, and had excellent antitumor activity in a MDA-MB-435 xenograft model without evidence of toxicities.. Our previous modeling and biological studies showed that an ethyl ester is optimal at the C2 substitution of the pyrrole, providing favorable alkyl length and hydropathic properties into the sites ...
The CD-spiroacetal contg. C16-C28 subunit I, as used in the total synthesis of the potent cytotoxic macrolide altohyrtin A (spongistatin 1), was prepd. by an alternative route using substrate-based stereocontrol in the two aldol bond constructions generating the acyclic precursor II ...
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TY - JOUR. T1 - Phase i study of the halichondrin B analogue eribulin mesylate in combination with cisplatin in advanced solid tumors. AU - Koczywas, M.. AU - Frankel, P. H.. AU - Synold, T. W.. AU - Lenz, H. J.. AU - Mortimer, J. E.. AU - El-Khoueiry, A. B.. AU - Gandara, David R. AU - Cristea, M. C.. AU - Chung, V. M.. AU - Lim, D.. AU - Reckamp, K. L.. AU - Lau, Derick H. AU - Doyle, L. A.. AU - Ruel, C.. AU - Carroll, M. I.. AU - Newman, E. M.. PY - 2014/12/9. Y1 - 2014/12/9. N2 - Background:Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and clinical settings. This phase I study aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetics in combination with cisplatin (CP) in patients with advanced solid tumours.Methods:Thirty-six patients with advanced solid tumours received eribulin mesylate 0.7-1.4 mg m-2 and CP 60-75 mg m-2. Eribulin mesylate was ...
TY - JOUR. T1 - The efficacy and safety of ixabepilone monotherapy in the treatment of breast and gynecologic malignancies. AU - Gupta, Divya. AU - Mani, Sridhar. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Ixabepilone is a semisynthetic analogue of epothilone B, a novel microtubule-stabilizing agent. Preclinical data suggest that its mechanisms of actions are different from those of the most commonly used microtubule- stabilizing agent, paclitaxel. This information in addition to the cytotoxicity of this drug in taxane-resistant cell lines in multiple solid tumors supports the fact that ixabepilone may be active in taxane-resistant tumors. Breast and gynecologic malignancies are leading causes of morbidity and mortality in women. Clinical studies demonstrate significant activity of ixabepilone monotherapy in these heavily pretreated patients. The toxicity profile of ixabepilone seems to be similar to that of taxanes and manageable by supportive methods.. AB - Ixabepilone is a semisynthetic analogue of ...
A unique and practical synthetic sequence for rapid access to polyketides and to further the spiroacetals derived from them, which utilizes a bidirectional Hosomi-Sakurai allylation approach around key allylsilanes in the synthesis of the AB and CD ring systems of spongistatin 1 and 2, is reported. The synthesis of the AB spiroacetal 9 requires 13 steps, with a longest linear sequence of seven steps in an overall yield of 27%. The synthesis of the CD spiroacetal 13 requires 15 steps, with a longest linear sequence of 11 steps in an overall yield of 30%. Both syntheses start from but-3-enol.. Keywords: double chain elongation ; enantioselectivity ; Hosomi-Sakurai reaction ; spiro compounds ; spongistatin ; Stereocontrolled Total-Synthesis ; Marine Macrolide Synthesis ; Sponge Hyrtios-Altum ; Formal Total-Synthesis ; Potent Cytotoxic Macrolides ; F-Ring Subunit ; Altohyrtin-A ; Natural-Products ; Modular Approach ; Ef-Fragment. ...
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HALAVEN has a high affinity to the plus end of microtubules, causing irreversible mitotic blockages. Please see the full Indication and Important Safety Information for HALAVEN.
This randomized phase II trial studies the side effects of atezolizumab with or without eribulin mesylate and how well they work in treating patients with
Eribulin mesylate (Halaven) geeft mediaan enkele maanden meer overall overleving bij weke delen tumoren, maar is nog lang geen genezende behandeling, toch is er wel hoop voor patienten met weke delen tumoren aldus reviewstudie. Artikel geplaatst 6 augustus 2018
PRIMARY OBJECTIVES:. I. To determine the safety and tolerability of the combination of vorinostat with ixabepilone.. II. To determine the best schedule for delivery of this drug combination. III. To recommend a phase II dose of vorinostat in combination with ixabepilone.. SECONDARY OBJECTIVES:. I. To determine the objective response rate and/or clinical benefit rate. II. To assess the toxicity profile.. TERTIARY OBJECTIVES:. I. Collecting circulating tumor cells pre and post-treatment to study its deoxyribonucleic acid (DNA) somatic mutation and methylation assay after the introduction of histone deacetylases (HDAC) inhibitors and ixabepilone.. II. To determine whether administration of vorinostat with ixabepilone will alter the pharmacokinetics of vorinostat.. OUTLINE: This is a phase I, dose-escalation study of vorinostat. Patients are randomized to 1 of 2 treatment arms.. Arm I (Cohort A): Patients receive oral vorinostat once daily on days 1-14 and ixabepilone intravenously (IV) over 3 hours ...
The NF-kB pathway is vital for immune system regu- lation and pro-inflammatory signaling. Many disor- ders and diseases, including cancer, can be linked to NF-kB dysregulation. When macrophages recognize the presence of a pathogen, the signaling pathway is activated - resulting in the nuclear translocation of NF- kB to turn on pro-inflammatory genes. Here, we demonstrate the effects of a novel microtubule depol- ymerizer, NT-07-16, a polysubstituted pyrrole on this process. Treatment with NT-07-16 decreased the pro- duction of pro-inflammatory mediators in a dose-de- pendent manner in RAW264.7 mouse macrophages. It appears that the reduction in pro-inflammatory me- diators by the macrophages after exposure to NT-07- 16 may be due to a decrease in the translocation of NF- κB into the nucleus. Therefore, this study suggests that, upon activation of mouse macrophages, NF-kB translocates into the nucleus by way of the microtu- bule network and that disruption of this network by NT-07-16 reduces the
Microtubules (MTs) are essential structural components of cells. They are made up of polymers of protein subunits of α,β-tubulin and are highly dynamic, undergoing rapid phases of assembly and disassembly. The dynamic behavior of MTs is essential for their cellular activities.
CLIP-170 staining after nocodazole treatment. CLIP-170 appears in green and chromosomes in red. 10-15 optical sections were merged for the final images. Oocyt
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013 ...
Ixabepilone - Get up-to-date information on Ixabepilone side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Ixabepilone
Satellite symposium will highlight advances in the use of novel cytotoxic agents for the treatment of metastatic breast cancer (MBC), non-small-cell lung...
Read Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
To determine the Maximally Tolerable Dose (MTD) of KOS-1022 when administered weekly in combination with trastuzumab or in combination with trastuzumab
Access downloadable HALAVEN® resources & links for metastatic breast cancer patients. Please see the full Indication and Important Safety Information for HALAVEN®.
This neoadjuvant trial compared the efficacy and tolerability of sequential cyclophosphamide + doxorubicin [AC] followed by ixabepilone [Epothilone, Xempra,
|strong|Mouse anti Tubulin beta 3 antibody, clone TU-20|/strong| recognizes class III beta-tubulin which is reported to be restricted to neuronal tissue.|br||br|Mouse anti Tubulin beta 3 antibody, clo…
Lipid classes were separated by thin-layer chromatography, sprayed with a primuline solution and quantified by integrating variable pixel intensities of the scanned plates. The values represent the mean of three Paclitaxel Microtubule inhibitor indep..
TPPP - TPPP (untagged)-Human tubulin polymerization promoting protein (TPPP) available for purchase from OriGene - Your Gene Company.
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mise jour, larticle date du 26 mai 2015 Quercetin and 2-Methoxyestradiol (2-ME) are promising anti-cancer substances. Our previous in vitro study showed that