Global Transient Receptor Potential Cation Channel Subfamily V Member 1 Market Report allows a reader to obtain an absolute evaluation of each influential factor involved in the Global Transient Receptor Potential Cation Channel Subfamily V Member 1 industry. The report primarily focuses to provide details of the market size which remains essential for every individual or company who has been performing in the market or interested for investment. The report includes a thorough evaluation of the historic and present status of the market and offers forecast estimations for market size, share, sales volume, and anticipations.. Request Global Transient Receptor Potential Cation Channel Subfamily V Member 1 Market Research Sample Report: https://www.marketresearchexplore.com/report/global-transient-receptor-potential-cation-channel-subfamily-v-member-1-market-analysis-2012-2017-and-forecast-2018-2023/87249#enquiry. In the report, the global Transient Receptor Potential Cation Channel Subfamily V ...
[103 Pages Report] Check for Discount on Transient Receptor Potential Cation Channel Subfamily V Member 1 (Capsaicin Receptor or Vanilloid Receptor 1 or TRPV1) - Pipeline Review, H2 2017 report by Global Markets Direct. Transient Receptor Potential Cation Channel Subfamily V Member 1 (Capsaicin...
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD)
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
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Structural and Functional Interactions between Transient Receptor Potential Vanilloid Subfamily 1 and Botulinum Neurotoxin Serotype A. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Biomatik Corporation Mouse Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) ELISA Kit, 96 tests MOUSE TRANSIENT RE_ELISA 96T
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels. The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). TRPV1 is a nonselective cation channel that may be activated by a wide variety of exogenous and endogenous physical and chemical stimuli. The best-known activators of TRPV1 are: temperature greater than 43 °C (109 °F); acidic conditions; capsaicin, the irritating compound in hot chili peppers; and allyl isothiocyanate, the pungent compound in mustard and wasabi. The ...
TY - JOUR. T1 - Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking. AU - Xu, Hongshi. AU - Fu, Yi. AU - Tian, Wei. AU - Cohen, David. PY - 2006/5. Y1 - 2006/5. N2 - We identified a consensus N-linked glycosylation motif within the pore-forming loop between the fifth and sixth transmembrane segments of the osmoresponsive transient receptor potential (TRP) channel TRPV4. Mutation of this residue from Asn to Gln (i.e., TRPV4N651Q) resulted in loss of a slower migrating band on anti-TRPV4 immunoblots and a marked reduction in lectin-precipitable TRPV4 immunoreactivity. HEK293 cells transiently transfected with the mutant TRPV4N651Q exhibited increased calcium entry in response to hypotonic stress relative to wild-type TRPV4 transfectants. This increase in hypotonicity responsiveness was associated with an increase in plasma membrane targeting of TRPV4N651Q relative to wild-type TRPV4 in both HEK293 and COS-7 cells but had no ...
Purpose: Peripheral artery disease (PAD) with chronic arterial occlusion leads to growth of collaterals - a process termed arteriogenesis. It was previously shown that fluid shear stress (FSS), which is also known to be an initial trigger of collateral growth, activates the transient receptor potential cation channel, subfamily V, member 4 (Trpv4). The aim of our study was to enhance collateral growth via Trpv4 activation in a pig hind limb ischemia model.. Methods: Domestic pigs (n=32, 40±1kg) were subjected to femoral artery ligature. 4α-Phorbol 12,13-didecanoate (4α-PDD, a Trpv4 activator) in different concentrations (9, 18, and 36 μg/kg/day) or 0.7 mg/kg/day Ruthenium Red (RR, a Trpv4-blocker) were infused into the femoral artery via an osmotic mini pump proximal to the ligature (n=26). NaCl-filled minipumps served as controls (n=6). Before, directly after ligature and on day 7 aortic and peripheral (A. saphena) mean arterial pressure (MAP) were measured, and angiographic images were ...
Infobox_gene}} The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the [[capsaicin]] receptor and the vanilloid receptor 1, is a [[protein]] that, in humans, is encoded by the TRPV1 [[gene]]. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group.,ref name="pmid9349813">{{cite journal , vauthors = Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D , title = The capsaicin receptor: a heat-activated ion channel in the pain pathway , journal = Nature , volume = 389 , issue = 6653 , pages = 816-24 , date = October 1997 , pmid = 9349813 , doi = 10.1038/39807 }},/ref>,ref name="pmid11549313">{{cite journal , vauthors = Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA , title = The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants , journal = ...
Trpc7 (untagged) - Mouse transient receptor potential cation channel, subfamily C, member 7 (Trpc7), transcript variant 3, 10 µg.
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in hum
ID TRPV5_RAT Reviewed; 723 AA. AC Q9JIP0; Q5UC98; Q9JJL2; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 05-JUL-2017, entry version 120. DE RecName: Full=Transient receptor potential cation channel subfamily V member 5; DE Short=TrpV5; DE AltName: Full=Calcium transporter 2 {ECO:0000303,PubMed:10875938}; DE Short=CaT2 {ECO:0000303,PubMed:10875938}; DE AltName: Full=Epithelial calcium channel 1; DE Short=ECaC1; DE AltName: Full=Osm-9-like TRP channel 3; DE Short=OTRPC3; GN Name=Trpv5; Synonyms=Cat2, Ecac, Ecac1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR RP LOCATION, AND TISSUE SPECIFICITY. RC STRAIN=CD1 Charles River; TISSUE=Kidney cortex; RX PubMed=10875938; DOI=10.1074/jbc.M909686199; RA Peng ...
Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss. This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel, TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. TRPV5 has been shown to interact with S100A10. TRPV ENSG00000127412 GRCh38: Ensembl release 89: ENSG00000274348, ENSG00000127412 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000036899 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Müller ...
Science 24 May 2013: Vol. 340 no. 6135 pp. 968-971 The Cells and Circuitry for Itch Responses in Mice. Santosh K. Mishra, Mark A. Hoon. Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Building 49, Room 1A16, 49 Convent Drive, Bethesda, MD 20892, USA.. [paraphrase]. Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms underlying this nociceptive response remain poorly understood. Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb−/− mice selectively lose almost all behavioral responses to itch-inducing agents. Nppb triggered potent scratching when injected intrathecally in wild-type and Nppb−/− mice, showing that this neuropeptide evokes itch when released from somatosensory neurons. Itch responses were blocked by ...
A-Kinase anchoring protein 150 (AKAP150) is required for the phosphorylation of transient receptor potential cation channel subfamily V member 1 (TRPV1) by PKA or PKC in sensory neurons and, hence, affects TRPV1-dependent hyperalgesia under pathological conditions. Recently, we showed that the activation of N-methyl-D-aspartate (NMDA) receptors sensitizes TRPV1 by enhancing serine phosphorylation through PKC in trigeminal nociceptors. In this study, we extended this observation by investigating whether AKAP150 mediates NMDA-induced phosphorylation of TRPV1 via PKC in native sensory neurons in the rat. By adopting a phospho-specific antibody combined with a surface biotinylation assay, we first assessed NMDA-induced changes in the phosphorylation level of serine 800 residues (S800) in TRPV1 delimited to cell surface membrane in cultured trigeminal ganglia (TG). The biotinylation assay yielded that the application of NMDA significantly increased the phosphorylation of S800 (p-S800) of TRPV1 at ...
Complete information for TRPV5 gene (Protein Coding), Transient Receptor Potential Cation Channel Subfamily V Member 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for TRPV6 gene (Protein Coding), Transient Receptor Potential Cation Channel Subfamily V Member 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
TY - JOUR. T1 - Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. AU - Ghilardi, Joseph R.. AU - Röhrich, Heidi. AU - Lindsay, Theodore H.. AU - Sevcik, Molly A.. AU - Schwei, Matthew J.. AU - Kubota, Kazufumi. AU - Halvorson, Kyle G.. AU - Poblete, Jeannie. AU - Chaplan, Sandra R.. AU - Dubin, Adrienne E.. AU - Carruthers, Nicholas I.. AU - Swanson, Devin. AU - Kuskowski, Michael. AU - Flores, Christopher M.. AU - Julius, David. AU - Mantyh, Patrick W.. PY - 2005/3/23. Y1 - 2005/3/23. N2 - Cancer colonization of bone leads to the activation of osteoclasts, thereby producing local tissue acidosis and bone resorption. This process may contribute to the generation of both ongoing and movement-evoked pain, resulting from the activation of sensory neurons that detect noxious stimuli (nociceptors). The capsaicin receptor TRPV1 (transient receptor potential vanilloid subtype 1) is a cation channel expressed by nociceptors that detects multiple pain-producing stimuli, ...
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4), also known as TRP12, OTRPC4 or VROAC, is a protein that in humans is encoded…
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
ID E1BCP0_BOVIN Unreviewed; 871 AA. AC E1BCP0; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 02-NOV-2010, sequence version 1. DT 22-NOV-2017, entry version 59. DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313,Ensembl:ENSBTAP00000000034}; GN Name=TRPV4 {ECO:0000313,Ensembl:ENSBTAP00000000034}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313,Ensembl:ENSBTAP00000000034, ECO:0000313,Proteomes:UP000009136}; RN [1] {ECO:0000313,Ensembl:ENSBTAP00000000034, ECO:0000313,Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313,Ensembl:ENSBTAP00000000034, RC ECO:0000313,Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., ...
context" : "http://schema.org", "@type" : "Product", "name" : " Mouse TRPV1(Transient Receptor Potential Cation Channel Subfamily V, Member 1)ELISA Kit (MOES01265)", "image" : "https://www.elisagenie.com/product_images/z/661/SC-E-EL-M0787__33566 ...
The aim of the study was to investigate the role of vanilloid transient receptor potential cation channel (TRPV4) in the regulation of rat pulmonary artery smoo...
A possible mechanism of oesophageal hypersensitivity is the acid-induced activation of transient receptor potential vanilloid receptor 1 (TRPV1) in the primary sensory neurons. We investigated TRPV1 expression and its colocalization with substance P (SP) and isolectin B4 (IB4)-positive cells in the thoracic dorsal root ganglia (DRGs) and nodose ganglia (NGs) of rats with reflux-induced oesophagitis (RO). RO was developed by fundus ligation and partial obstruction of the pylorus of Sprague-Dawley rats. Four groups of rats were used; fundus ligated acute (RO 48 h), chronic 7 days (RO 7D), RO 7D + omeprazole (7D + Omz, 40 mg kg(-1), i.p.) and sham-operated controls. Immunohistochemical analysis of TRPV1, SP and IB4 expression were carried out in spinal cord (SC), DRGs and NGs. RO rats exhibited significant inflammation and increase in TRPV1-ir and SP-ir expressions in the SC, DRGs and NGs. The maximum colocalization of TRPV1 and SP was observed in RO 7D rats, but Omz prevented inflammation and over ...
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Contrary to popular belief, CBD does not primarily bind to the classical receptors CB1 and CB2, but interacts mainly with the G protein Coupled Receptor GPR55, the Peroxisome Proliferator-Activated Receprot gamma (PPARγ) and ion channels such as the vanilloids Transient Receptor Potential Channels (TRPV1, TRPA1). CBD is a complete agonist of Transient Receptor Potential Vanilloid Type 1 (TRPV1), which plays an important role in the reaction to hot (e.g. boiling water) and harmful substances. TRPV1 is a nociceptor: When the receptor is sufficiently stimulated, signals are sent to the brain. This triggers a series of automatic reactions, including pain sensation. Various cannabinoids, including the endocannabinoids anandamide and N-arrachidonyl dopamine (an agonist of the CB1 receptor), affect the TRPV1 receptor. Conversely, several vanilloids affect cannabinoid receptors, including olvanil and pseudocapsaicin (nonivamide), but not capsaicin itself. The close chemical relationship between many ...
Previous studies showed that flow activates TRPV4 in TRPV4-overexpressing HEK cells.8 However, the detailed activation mechanism remains obscure. In the present study, we found that coexpression of TRPC1 with TRPV4 altered the decay kinetics of flow-induced [Ca2+]i increase and 4α-PDD-stimulated whole-cell current; it also enabled the [Ca2+]i transient to be negatively regulated by PKG. Interfering TRPC1 with T1E3 or TRPC1Δ567-793 diminished the [Ca2+]i increase in TRPV4-C1-coexpressing HEK cells. Coimmunoprecipitation, FRET, and subcellular colocalization experiments demonstrated a close physical association of TRPV4 with TRPC1. These data strongly suggest a physical interaction of TRPC1 with TRPV4 and an important functional role of this interaction in flow-induced Ca2+ influx.. TRPV4 is abundantly expressed in vascular endothelial cells,19 and plays a key role in flow-induced endothelial Ca2+ influx and subsequent vascular dilation.2,3 Interestingly, flow-induced [Ca2+]i transient in native ...
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
TRPA1 antibody (transient receptor potential cation channel subfamily A member 1) for IHC-P. Anti-TRPA1 pAb (GTX38865) is tested in Human samples. 100% Ab-Assurance.
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016] ...
Information are expressed in pg/mg protein and represent signifies six SEM of 6 to 8 animals for each group. P,.05 compared to sham-operated team.Determine two.
Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, is a receptor activated by high temperatures and chemical agonists such as the vanilloids and protons. Because of these properties, TRPV1 has emerged as a polymodal nocisensor of nociceptive afferent neurons. TRPV1 is thought to be a central transducer of hyperalgesia and a prime target for controlling pain pharmacologically because it is a point where many proalgesic pathways converge and it is upregulated and sensitized by inflammation and injury. However, whether TRPV1 agonists promote or inhibit inflammation remains unclear. We recently demonstrated that SA13353 (1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea), a novel TRPV1 agonist, inhibits tumor necrosis factor-a production by the activation of capsaicin-sensitive afferent neurons and reduces the severity of symptoms in kidney injury, lung inflammation, arthritis, and encephalomyelitis. These results suggest that TRPV1 agonists may act as anti
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse painful stimuli. In this review, we first describe the chemical and pharmacological properties of capsaicin and its derivatives in relation to their analgesic properties. We then consider the biochemical and functional characteristics of TRPV1, focusing on its distribution and biological effects within the somatosensory and viscerosensory nociceptive systems. Finally, we discuss the use of capsaicin as an agonist of TRPV1 to model acute inflammation in slices and other ex vivo preparations.. ...
Transient receptor potential vanilloid 4 (TRPV4) channels are expressed in brain neurons involved in systemic osmoregulation; and intravenous administration of TRPV4 channel antagonists elevates arterial pressure in peripheral. Here, we examined the role of TRPV4 in the regulation of blood pressure and neuronal activity in the PVN of Dahl S and Dahl R rats. Microinjection of TRPV4 antagonists, HC067047 (10 uM, in 50 nl) or ruthenium red (10 uM, in 50 nl), into the PVN significantly increased mean arterial pressure (MAP) and heart rate (HR) in both Dahl R and Dahl S rats on either high salt or normal diet. However, the pressor and tachycardia effects of TRPV4 channel blockers were significantly impaired in Dahl S rats on high salt diet as compared with other groups of rats. In contrast, PVN microinjection of the TRPV4 agonist, GSK1016790A (100 nM, in 50 nl), markedly reduced MAP and HR in all groups of rats. The depressor and bradycardia effects induced by TRPV4 stimulation were significantly ...
Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies.. ...
In this review, we provide lines of accumulating evidence to support the hypothesis that melittin is the major pain-producing substance of bee venom. At the psychophysical and behavioral levels, subcutaneous injection of melittin causes tonic pain sensation and pain-related behaviors in both humans and animals. At the cellular level, melittin activates primary nociceptor cells through direct and indirect effects. On one hand, melittin can selectively open thermal nociceptor transient receptor potential vanilloid receptor channels via phospholipase A2-lipoxygenase/cyclooxygenase metabolites, leading to depolarization of primary nociceptor cells. On the other hand, algogens and inflammatory/pro-inflammatory mediators released from the tissue matrix by melittins pore-forming effects can activate primary nociceptor cells through both ligand-gated receptor channels and the G-protein-coupled receptor-mediated opening of transient receptor potential canonical channels. Moreover, subcutaneous melittin ...
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 2, mRNA. (H00007442-R01) - Products - Abnova
Tissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown. Here we showed that a single intramuscular acid injection induced a priming effect on muscle nociceptors of mice. The primed muscle nociceptors were plastic and permitted the development of long-lasting chronic hyperalgesia induced by a second acid insult. The plastic changes of muscle nociceptors were modality-specific and required the activation of acid-sensing ion channel 3 (ASIC3) or transient receptor potential cation channel V1 (TRPV1). Activation of ASIC3 was associated with increased activity of tetrodotoxin (TTX)-sensitive voltage-gated sodium channels but not protein kinase Cϵ (PKCϵ) in isolectin B4 (IB4)-negative muscle nociceptors. In contrast, increased activity of TTX-resistant voltage-gated sodium channels with ASIC3 or TRPV1 activation in NaV1.8-positive muscle nociceptors was required for the development of chronic
RECENT FINDINGS: Mounting evidence supports the effectiveness of acupuncture to treat chronic low back, neck, shoulder, and knee pain, as well as headaches. Additional data are emerging that support the use of acupuncture as an adjunct or alternative to opioids, and in perioperative settings. Findings related to its mechanisms of action include transient receptor potential cation channel vanilloid 1 activation in the periphery, microglial suppression in the cerebral cortex and spinal cord, and regulation of cytokines and other key inflammatory factors in the spinal cord. Incremental integration of acupuncture into pain medicine practices and training programmes continues to grow ...
Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following myocardial infarction (MI), but the critical neural pathways involved are not well understood. Cardiac adrenergic function is partly regulated by sympathetic afferent reflexes, transduced by spinal afferent fibers expressing the transient receptor potential cation subfamily V member 1 (TRPV1) channel. The role of chronic TRPV1 afferent signaling in VAs is not known. We hypothesized that persistent TRPV1 afferent neurotransmission promotes VAs after MI. Using epicardial resiniferatoxin (RTX) to deplete cardiac TRPV1-expressing fibers, we dissected the role of this neural circuit in VAs after chronic MI in a porcine model. We examined the underlying mechanisms using molecular approaches, IHC, in vitro and in vivo cardiac electrophysiology, and simultaneous cardioneural mapping. Epicardial RTX depleted cardiac TRPV1 afferent fibers and abolished functional responses to TRPV1 agonists. Ventricular ...
Objective Transient receptor potential vanilloid type 1 (TRPV1) has been shown to play an important role in visceral hypersensitivity. A significant proportion of patients with inflammatory bowel disease (IBD) continue to complain of abdominal pain despite their disease being otherwise quiescent. We investigated TRPV1-immunoreactive fibres in rectosigmoid biopsies taken from such patients with correlation to abdominal pain severity.. Methods Rectosigmoid biopsies were collected from 20 patients with quiescent IBD fulfilling Rome II criteria for irritable bowel syndrome (IBS), from 20 asymptomatic patients with quiescent IBD and from 28 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1- and neuronal marker protein gene product 9.5 (PGP 9.5)-expressing nerve fibres, and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to abdominal pain scores.. Results A significant 3.9-fold ...
transient receptor potential cation channel, subfamily C, member 4 associated protein; targeted mutation 1a, Wellcome Trust Sanger Institute ...
Intracellular calcium-permeable channels have been implicated in thermogenic function of murine brown and brite/beige adipocytes, respectively transient receptor potential melastin-8 and transient receptor potential vanilloid-4. Because the endo-lysosomal two-pore channels (TPCs) have also been ascribed with metabolic functionality, we studied the effect of simultaneously knocking out TPC1 and TPC2 on body composition and energy balance in male mice fed a chow diet. Compared with wild-type mice, TPC1 and TPC2 double knockout (Tpcn1/2(-/-)) animals had a higher respiratory quotient and became obese between 6 and 9 months of age. Although food intake was unaltered, interscapular brown adipose tissue (BAT) maximal temperature and lean-mass adjusted oxygen consumption were lower in Tpcn1/2(-/-) than in wild type mice. Phosphorylated hormone-sensitive lipase expression, lipid density and expression of β-adrenergic receptors were also lower in Tpcn1/2(-/-) BAT, whereas mitochondrial respiratory chain
Transient receptor potential vanilloid-1 (TRPV1) agonist; topical application causes initial TRPV1 stimulation that may cause pain, followed by pain relief by reduction in TRPV1-expressing nociceptive nerve endings"[1] ...
TY - JOUR. T1 - Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons. AU - Sousa-Valente, João. AU - Varga, Angelika. AU - Torres-Perez, Jose Vicente. AU - Jenes, Agnes. AU - Wahba, John. AU - Mackie, Ken. AU - Cravatt, Benjamin. AU - Ueda, Natsuo. AU - Tsuboi, Kazuhito. AU - Santha, Peter. AU - Jancso, Gabor. AU - Tailor, Hiren. AU - Avelino, António. AU - Nagy, Istvan. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Elevation of intracellular Ca2+ concentration induces the synthesis of N-arachydonoylethanolamine (anandamide) in a subpopulation of primary sensory neurons. N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is the only known enzyme that synthesizes anandamide in a Ca2+-dependent manner. NAPE-PLD mRNA as well as anandamides main targets, the excitatory transient receptor potential vanilloid type 1 ion ...
BioAssay record AID 242111 submitted by ChEMBL: Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1.
Transient receptor potential (TRP) vanilloid 1 (TRPV1) is well recognized as a polymodal molecular pain receptor that responds to a wide range of stimuli including noxious heat ,43°C, chemical agonists, and protons (Caterina et al., 1997; Tominaga et al., 1998). TRPV1 responses to these stimuli signal the exposure to extreme temperature or tissue damage to elicit appropriate protective mechanisms. TRPV1 is well characterized for its activation by capsaicin, a naturally occurring compound found in chili peppers (Caterina et al., 1997). Prolonged activation of TRPV1 with capsaicin results in acute desensitization, where TRPV1 activity decreases during the course of stimulation. In contrast, repeated stimulation of TRPV1 results in tachyphylaxis, where TRPV1 activation decreases with successive stimulation followed by loss of response to any subsequent stimuli.. TRPV1 belongs to the TRP superfamily of nonselective cation channels with high relative permeability for Ca2+ (Caterina et al., 1997). ...
Somogyi, C, Matta, C, Foeldvari, Z, Katona, E, Takacs, RA, Juhasz, T, Nanasi, PP, Hegyi, B, Szentandrassy, N and Zakany, R (2012) Embryonic chicken and murine chondrogenic cells express TRPV1 channels that influence cartilage formation In: 22nd International-Union-of-Biochemistry-and-Molecular-Biology (IUBMB) Congress/37th Federation-of-European-Biochemical-Societies (FEBS) Congress, 2012-09-04 - 2012-09-09, Seville, SPAIN. Full text not available from this repository ...