Various preparations of Tripterygium wilfordii Hook F (TwHF) have been used in the treatment of a number of autoimmune and inflammatory diseases since the 1960s. Accumulated data from the clinical trials suggest efficacy of this treatment in a number of rheumatic diseases, including rheumatoid arthr …

China Tripterygium Wilfordii Extract, China Tripterygium Wilfordii Extract Suppliers and Manufacturers Directory - Source a Large Selection of Tripterygium Wilfordii Extract Products at seaweed extract ,tomato extracting machine ,schisandra extract with 2% schisandrins from China Alibaba.com

The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely used in the treatment of autoimmune and inflammatory diseases. Over the past few decades, great efforts have been made to explore modern preparations of TwHF with higher efficacy, solubility, and lower toxicity. In this study, we reviewed several examples both of naturally occurring compounds and their derivatives in TwHF, and summarized the preclinical evaluations with regard to autoimmune and inflammatory diseases. All of the candidate compounds described herein have been or are currently in clinical trials. Although some studies encountered problems, the data still provided valuable references for future studies. (5R)-5-hydroxytriptolide (LLDT-8, Leitengshu) is a novel triptolide derivative with potent immunosuppressive and anti-inflammatory activities developed at Shanghai Institute of Materia Medica. Indeed, a Phase I clinical trial for this compound has been completed in rheumatoid arthritis patients. The results

Although HIV-1 infection is characterized by progressive depletion of CD4+ T cells that eventually leads to clinically significant immunodeficiency, a chronic generalized immune activation is now being recognized to be the main driving force for T cell depletion, loss of anti-HIV-1 immunity and disease progression during chronic HIV-1 infection. In particular, this immune activation has been identified as a disease determinant independent of viral load or cell death in HIV-1 infection. A series of clinical evidences have indicated that activated CD8 T cells may attack body cells infected with viruses. Because of this, CD4 cells infected with HIV are frequently destroyed by CD8 cells.. In traditional Chinese medicine, extracts of the roots of the medicinal vine Tripterygium wilfordii Hook F (TwHF) (known in China as lei gong teng or thunder god vine) have shown therapeutic promise in treating autoimmune and inflammatory conditions as well as cancer. In this extracts, three ...

Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in adults. Over the past decade, a number of studies have reported therapeutic efficacy for treatment with tacrolimus plus steroid in patients with nephrotic syndrome including patients with membranous nephropathy. This study will evaluate the safety and effectiveness of a traditional herbal extraction, Tripterygium wilfordii, plus steroid in reducing the amount of protein in the urine in patients with membranous nephropathy. A hundred patients with biopsy-proven membranous nephropathy will be recruited. They will be screened with a medical history, physical examination, blood tests, and an examination for infection, cancers, and other conditions that can cause membranous nephropathy. The investigators plan to conduct an open-label study of the efficacy and safety of Tripterygium wilfordii in the treatment of membranous nephropathy. Half of them will be treated with oral Tripterygium wilfordii plus steroids for 6 ...

Learn more about Tripterygium wilfordii at Doctors Hospital of Augusta Thundergod Vine, Lei Gong Teng Uses Principal Proposed Uses Rheumatoid...

Learn more about Tripterygium wilfordii at LewisGale Regional Health System Thundergod Vine, Lei Gong Teng Uses Principal Proposed Uses ...

This trial will assess the efficacy of tripterygium wilfordii Hook-F in patients with active ankylosing spondylitis. The primary endpoints are immunoglobulin A,

Buy Healthy Plant Extract Tripterygium Wilfordii Extract 38748-32-2 High Purity direct from Pharmaceutical Raw Material of China Factory that provide Latest Pharmaceutical Raw Material - rawpowdersanabolic.

Quercetin (Que) is one of main compounds in Lysimachia christinae Hance (Christina loosestrife), and has both medicinal and nutritional value. Glycosides from Tripterygium wilfordii Hook.f. (léi gōng téng [the thunder duke vine]; TG) have diverse and broad bioactivities but with a high incidence of liver injury. Our previous study reported on the hepatoprotective properties of an ethanol extract from L. christinae against TG-induced liver injury in mice. This research is designed to observe, for the first time, the possible protective properties of the compound Que against TG-induced liver injury, and the underlying mechanisms that are involved in oxidative stress and anti-inflammation. The results indicated that TG caused excessive elevation in serum levels of alanine/aspartate transaminase (ALT/AST), alkaline phosphatase (ALP), gamma glutamyl transferase (γ-GT), and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α), as well as hepatic lipid peroxidation (all P | 0.01). On the other

Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The incidence has shown that no significant sign of decline throughout the past 20 years and almost equals its mortality[1-3]. The 5-year survival rate for this disease is less than 4% and the median survival time after diagnosis is less than 6 mo[2,3]. Surgical resection of the tumor is still the only effective treatment option, although only 20% of carcinomas of the head of the pancreas are resectable[4].Furthermore, the median survival even after apparent curative resection is only 20 mo, because of early tumor recurrence or rapid metastatic spread[2,4]. Other treatment options, such as chemotherapy or radiation therapy, provide limited palliation without significant improvement of survival in patients with unresectable pancreatic cancer[2]. Therefore; new targets for chemo-preventive and therapeutic agents need to be identified.Triptolide (TL), extracts of the Chinese herb ...

Thunder god vine is used in traditional Chinese medicine for inflammatory conditions such as arthritis. Discover Thunder God Vines interesting benefits.

All Author(s) ListBUT Pui Hay Paul, SHAW Pang Chui, LAW Ka Yee, HE MINGFANG, CHENG Ling, JIANG Renwang, XU Hong-xi, SIMMONS P. Mark, KHAN A. Ikhlas, TECHEN Natascha ...

Lei Gong Teng is also known as Thunder god vine. The bitter and very toxic herb has been used in TCM as an anti-inflammatiory and immunosuppressive agent and to resolve toxins, treat proteinuric renal disease, etc., as it expels Wind-Damp, resolves edema, calms pain, etc., by enhancing the functions of Liver and kidney channels. Ingredients …. ...

Celastrol is a natural bioactive compound extracted from the medicinal plant Tripterygium wilfordii Hook F. It exhibits immunosuppressive, anti-inflammatory, and antioxidant activities. Cisplatin is a commonly used chemotherapeutic drug in the treatment of a wide range of tumors. Although very effective therapeutically, it can cause nephrotoxicity leading to dose reduction or discontinuation of treatment. This study aims to clarify the therapeutic potential of celastrol in cisplatin-induced nephrotoxicity. The possible protective effects of celastrol pretreatment against cisplatin-induced oxidative stress and genotoxicity were investigated. A rat kidney epithelial cell line NRK-52E was pretreated with the desired concentrations of celastrol (200 nM, 100 nM, and 50 nM) for 24 h. The cells were treated with 50 mu M cisplatin for a further 24 h to see whether cisplatin caused the same or less toxicity compared to the vehicle control group. Alkaline comet assay was performed for genotoxicity ...

5459 Triptolide (TPL), a diterpenoid triepoxides-like small molecule purified from Tripterygium wilfordii Hook F., has been used as an anti-tumor and anti-inflammation agent with very promising results from clinical trails. For the better targeting on tumor and the reducing of TPL toxicity, the improvement of deliver formula of TPL is needed. Four forms of TPL Nan vehicles were prepared as follow: 1) TPL-PEG-Lip, which was made by enrapture of TPL in liposome (Lip) with 1,2-Dipalmitoyl-sn-Glycero-3-Phosphoethanolamine-N-[Amino (Polyethylene Glycol) 2000] (H2N-PEG-DPPE); 2) TPL-Fol-PEG-Lip, which utilized the folate to enhance the targeting ability to tumor cells via the over-expressed folate receptors; 3) TPL-Transferrin-Lip, which utilized the transferrin to target tumor cells via transferring receptors; and 4) TPL-hyaluronan (HA)-Lip, which utilized the hyaluronan as ligand for CD44 over-expressed on surface of tumor cells. The effects of different TPL nanovehicles on the tumor cell growth ...

1 Answer - Posted in: cancer, thunder god vine - Answer: It has been investigated for rheumatoid arthritis where it shows most ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research. Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities againstmouse models of polycystic kidney disease[1] and http://en.wikipedia.org/wiki/Pancreatic_cancer” rel=nofollow,pancreatic cancer, but its physical properties limit its therapeutic potential.[2] Consequently, a synthetic prodrug, minnelide, … Continue reading →. ...

Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research. Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities againstmouse models of polycystic kidney disease[1] and http://en.wikipedia.org/wiki/Pancreatic_cancer” rel=nofollow,pancreatic cancer, but its physical properties limit its therapeutic potential.[2] Consequently, a synthetic prodrug, minnelide, … Continue reading →. ...

multiglycosidorum tripterygii: immunosuppressant extracted from Tripterygium Wilfordii Hook-F (TW) and refined repeatedly; it chiefly contains glycosides with stable quality and has less side effects than other crude extracts of TW

A chemical compound called triptolide is among the more than 100 bioactive ingredients derived from the Thunder God vine. Preclinical studies showed a pharmaceutical version of triptolide called Minnelide proved effective against pancreatic cancer cells, according to a study by Dr. Ashok K. Saluja, Professor and Vice-Chair, Department of Surgery, University of Minnesota and Chief Scientific Officer and Co-Founder of Minneamrita Therapeutics LLC, published in the journal Science Translational Medicine.. The U.S. Food and Drug Administration (FDA) recently approved use of the compound Minnelide for a clinical trial of gastrointestinal cancer patients - including pancreatic cancer.. We have known for years about the potential beneficial use of Thunder God vine, but only recently with the advent of Minnelide have we created a form of triptolide that can be easily administered to patients, said Dr. Mohana R. Velagapudi, Chief Executive Officer and Co-Founder of Minneamrita Therapeutics LLC, the ...

Asano Kazuhito , Sugimoto Kayo , Watanabe Tomiko , Hisano Masataka , Hisamitsu Tadashi The effects of chloroform extract of ,i,Tripterygium wilfordii,/i, Hook ,i,f,/i, (TWH extract) on eosinophilia and IgE hyperproduction induced by ,i,Mesocestoides cortii& … Allergology International 49(1), 37-45, 2000 J-STAGE ...

Authors: Zhang J, Guan Y, He L, Tao L, Zang Z, Zhu W, Chen L, Jin C Abstract Topical administration of triptolide (TP) is effective in the treatment of rheumatoid arthritis (RA), but it can also induce skin irritation. Previous studies have used data mining strategies to analyze the application of Tripterygium wilfordii in the treatment of RA and have shown that TP and ferulic acid (FA) can be used in combination due to their component compatibility. The aims of the present study were to investigate the mechanisms underlying the effects of TP treatment and to identify its effects on metabolism and oxidative damage ...

This Arthritis Guide Takes It One Step Further. There has never been a Arthritis Guide like this. |p||p|It contains 196 answers, much more than you can imagine; comprehensive answers and extensive details and references, with insights that have never before been offered in print. Get the information you need--fast! This all-embracing guide offers a thorough view of key knowledge and detailed insight. This Guide introduces what you want to know about Arthritis. |p||p|A quick look inside of some of the subjects covered: Septic arthritis - Diagnosis, Shoulder surgery - Arthritis or Osteolysis of the AC (acromioclavicular) joint, Reactive arthritis - Notable cases, Wrist osteoarthritis - Medical history, Inflammatory arthritis, Osteoarthritis - Dietary supplements, Clarins - The Courtin Arthritis Foundation, Arthritis Research UK - Vision, Inflammatory arthritis - Symptoms and signs, Reactive arthritis - Causes, Tripterygium wilfordii - Rheumatoid arthritis, Arthritis Care - People, Polyarthritis -

Now for the worry part, the sonologist also noted a fibroid measuring 2.5 x 1.8 cms in the anterior wall of the uterus. Compared with conventional medication, one herbal preparation, Tripterygium wilfordii, may have a more beneficial effect in reducing the volume of uterine fibroids. These natural ones do the job just as effectively as the do fibroid tumors bleed kit and are readily available on the internet. For infertile women with intracavitary or submucosal fibroids which distort the uterine cavity, myomectomy surgery is likely to improve fertility.

MTX Audio Monoblock Amplifier Thunder Series THUNDER1000.1 The THUNDER line of amplifiers has seen numerous technological advancements throughout its life and continues to be one of the most recognized and sought after products in the car audio world today. The MTX THUNDER1000.1 amplifier is the product of many of thos

corner computer desk with hutch plans : wood baby cradle plans Xiv Results Shop for desks and desk hutches to convey order and vogue to your home After building was make out I. L Shaped street corner data processor Desk tungsten Hutch Shaker Cherry 439.98. Sauder Orchard Hills heavy Corner 50 Shape woodwind Computer Desk in Oak corner computer desk with hutch plans. 369.98 Contrive 03 603 3 Piece Corner Desk Hutch Plan 03 602 Corner electronic computer Desk contrive Combo Price Available drive 2 bang-up woodworking plans for a corner computer desk with hutch plans. His a la mode influence is a letter rack with an envelope in I of the slotsThe envelope reads, To constitute opened in the effect of my deathIn his freshly book The Lost Carving: A Journey to the Heart of Esterly writes that carving may comprise profession for high operation obsessive compulsives. ...

Celastrol, CAS 34157-83-0, is a high purity chemical. Isolated from Tripterygium. Leptin sensitizer. Anti-obesity, anticancer, anti-inflammatory antioxidant. NF-kB inhibitor. Apoptosis inducer. HSP90 inhibitor.

You searched on: Genus = Tripterygium and Ranks = gen and Hybrids only = false Found 1 record. Edit search View these results in delimited format: classic, minimal, short, extended ...

Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get them in front of Issuus millions of monthly readers. Title: Thunder Roads Magazine of Iowa January 2016, Author: Thunder Roads Magazine of Iowa, Name: Thunder Roads Magazine of Iowa January 2016, Length: 40 pages, Page: 1, Published: 2015-12-21

I designed The Thunders weekly magazine/news show Air Thunder with these basic principals in mind, the show would air on as many outlets as possible without having to be re-edited, providing additional revenue opportunities without any additional expenses. The program aired on Fox Sports Oklahoma, (regional cable) on the teams flagship radio station, sent out as a podcast, posted on the teams website, and posted on NewsOK.com.,.the multimedia arm of Oklahomas leading newspaper and the states #1 web site.. By forming a production and distribution partnership with NewsOK, an additional outlet for the program was created. Air Thunder set records for page views on NewsOK.com.. The Thunder game production staff, producers, editors as well as the on-air television and radio broadcasters all contribute to the show as part of their regular responsibilities with no additional cost to the team.. In the shows second year, the leading member of the states #1 morning radio show, a popular and ...

16/01/2021 , 5:55 pm , , Posted in Uncategorized A great old song by BRUCE SPRINGSTEEN as the Protagonist seeing himself in his own story, relating to the lonely of a Roy Orbison song that was playing on his car radio, while he was picking up Mary coming out on the porch of her house and seeing her with respect in the dancing light of a holy vision of MARY that was raised in his mind by having the Christian Catholic upbringing awareness. THUNDER ROAD - deutsche Übersetzung. D F#m G A Oh Thunder Road, Oh Thunder road, Oh Thunder Road. I just cant face myself alone again Well now Im no hero thats understood Climb in back, heavens waiting down on the tracks Inhalt. Related artists: Road, In extremo, In fear and faith, In flames, In-grid, In hearts wake, In league, In vain ( sp ) With a chance to make it good somehow Bruce Frederick Joseph Springsteen (born September 23, 1949), nicknamed The Boss, is an American singer-songwriter and multi-instrumentalist who records and tours with the E ...

Email. LEXINGTON, Ky. - The younger stallions are having all the success in this years Triple Crown, as Marias Mon sired Kentucky Derby winner Monarchos in his first crop of foals and Thunder Gulch got Preakness winner Point Given in his second crop. Among the placed horses, Thunder Gulch also sired Invisible Ink, who ran second in the Derby. These results are good news for Americas stallion corps. Among our better stallions, there is no shortage of high-quality horses who are likely to sire sprinters and milers, but there is definite opportunity for stallions who can sire the classic horse. Not only is television coverage weighted heavily toward coverage of the classics, but the really serious money in stallion syndications, stud fees, and yearling auctions is attracted to the sires who can get the best of the best. Consider for a moment the breeders reception of Thunder Gulch before and after his stock were proven on the racetrack. A winner of the Kentucky Derby and Belmont Stakes, Thunder ...

Flextone® Game Calls, the industry leader in natural game sounds, introduces the new-for-2014 Thunder™ Yelper.. Flextone® continues to turn the world of turkey calling on its ear with the new Thunder™ Yelper hybrid diaphragm turkey call. Unlike traditional diaphragm calls, the revolutionary Thunder™ Series hybrid hand held/diaphragm call design lets users of all experience levels sound like a pro quickly and easily. Produce woods-ready, expert-sounding turkey vocalizations in a matter of minutes of first use. A perfect choice for close to mid-range calling, the latex double reed voice box of the Thunder™ Yelper produces ultra-realistic soft and seductive yelps that boss toms just cant resist. Thanks to Flextone®-exclusive soft body technology, these handheld calls can be manipulated to tweak each yelp to your situation allowing your calls to sound like multiple hens, while giving that old gobbler even more incentive to pay a visit. Compact and lightweight theres plenty of room in ...

Os Thunder & Co. são uma banda que acompanhamos já há algum tempo, e este duo está cada vez melhor. Não foi a primeira vez que os vimos transformar o Musicbox numa pista de dança. Mas, foi a primeira vez que os vimos a fazerem isto, com a ajuda de alguns convidados. Na lista de convidados constavam Ben Monteiro, Alex Dalva Teixeira, Carolina B., Rui Maia, Nuno Saraja, Maria do Rosário, Frederico Costa e Ariel Rosa. O Musicbox por esta altura já estava muito bem composto, e não houve quem não mexesse as ancas. Os Dalva auxiliaram os Thunder & Co. no tema N.I.K., e ainda tocaram duas músicas suas. De seguida os Thunder & Co. interpretaram um tema dos Mirror People, em conjunto com os restantes convidados. O.N.O. acabou em beleza o concerto, com os convidados todos em palco. O concerto foi tudo o que podíamos esperar deste duo. Enérgico e electrizante. Uma coisa é certa: nunca nos cansamos de ver Thunder & Co., que foram indiscutivelmente o concerto da noite ...

The glowing ball of love that is the Oklahoma City Thunder bounces into the fourth season of its existence with every possible reason to feel good. Feeling good, in fact, is practically the Thunders whole mission statement. Since riding into town on a rainbow in 2008,1 the Thunder have overachieved (they made the playoffs in their second season, when they pushed the eventual-champion Lakers to six games; they won the division in their third, losing to the eventual-champion Mavericks in the Western Conference finals) while charming the town, creating one of the best fan experiences in the NBA, and soaking up all the good publicity that goes with being the closest thing the league has to the anti-Heat. A likable young superstar whos happy where he is! An inexpensively assembled roster2 of teammates who get along! Id seen the Thunder play before, in Boston, but it wasnt til I saw them in OKC last year that I really got this. There was an invitation folded over the back of my seat beckoning me ...

Our modular Tuscan home office furniture blends modern versatility with the classic looks of a custom built-in. Each piece in the collection works with every other, so you can design a storage solution or workstation to fit your space and needs perfectly. The Tuscan Cabinet Hutch with Doors offers a balanced combination of display and storage in the home office, family room, bedroom or kitchen. Behind its double beveled glass doors, the Hutch features one adjustable glass shelf for a light open look. Cable management below keeps everything neat and clutter-free. Paneled interior gives this versatile piece a finely crafted look that works with virtually any decor. Double cabinet doors conceal one adjustable shelf for stacking and storing. A single drawer above holds office supplies and everyday essentials. Stand multiple Cabinets Hutches side-by-side to make a custom-length hutch/credenza with as much storage and display as you need. Flush sides make it seamless and easy. Tuscan Cabinet Hutch with

Comparison of GE GTW335ASNWW VS Maytag MVWB965HC washers. Which is better? After a few trips I finally chose the Ge washer. GE GTW335ASNWW VS Maytag MVWB765FW washer. ft. High-Efficiency White Top Load Washing Machine with Soaking Cycles, We are here to help you to choose between your favorite washers models? Serwis dla słuchowców, tworzony z pasją, na którym nauczysz się języka angielskiego online inaczej niż w szkole. GE GTW335ASNWW VS Maytag MVWB965HC washer. Below you can see the most important specifications that you should check before GTW335ASNWW GE 4.2 cu. Comparison of GE GTW335ASNWW … I searched online and then went to Home Depot and Lowes. The old washer I had … Prices, Promotions, styles, and availability may vary. 3.8 cu. reviews). Be the first to learn about our special offers and sales. GE. Discover the benefits a Home Depot Consumer Credit Card has to offer. LG WT7300CW Washer Review and Demo. Compare; Find My Store. ft. White Top Load Washing Machine with Stainless ...

What is your initial reaction when someone mentions Chinese herbs to you? Do you picture some little old wizened Chinese man sitting cross-legged on a rock? Maybe you think of them as fake or something your grandmother might have used. Or, maybe you think they are the real deal. No matter what your current association […]. ...

With its crisp modern silhouette and lovely proportions, our Edith Desk with Hutch slips beautifully into virtually any space, from living room to bedroom. The slender desktop has three storage drawers, the center one just the right size for tucking in a laptop. Hutch has two open cubbies for pencil boxes, stationery and supplies. Both pieces are crafted of hardwood with fresh white finish. Airy campaign-style metal bases are hand finished in shimmering champagne for sophisticated contrast. This feminine desk with hutch also makes a pretty dressing table. Edith Desk with Hutch features: White finish Champagne finish metal bases Simple matching champagne finish knobs Full extension metal drawer glides Levelers for perfect alignment Assembly required

The Eglu Go Hutch is perfect for keeping rabbits and guinea pigs in the garden safely. The Eglu Go Guinea Pig Hutch and run is suitable for two to three guinea pigs, and the Rabbit hutch and run is ideal for two pet bunnies. The plastic rabbit and guinea pig house is easy to clean and insulated, making it perfect to use all year round and both come with fox-resistant run. See below to read about the Eglu Go Hutch.

How to Clean a Rabbit Hutch. Rabbits are relatively clean animals, but they still need to have their hutches cleaned on a regular basis. Do a quick clean of the hutch every day to remove old food and soiled bedding. The hutch should be...

Russell Westbrook and James Harden are supposed to be vital cogs in the Thunders Big Three, along with Kevin Durant. The trio combined for 4,452 points during the regular season, leading all NBA trios with an average of 68.4 points per game.. So when Durant started slow in Saturdays Game 4, and Westbrook and Harden both clanked through difficult shooting nights, it would have seemed to spell disaster for the Thunders NBA title hopes.. Instead, the Thunders unheralded collection of role players came up with a monster collective effort that kept them afloat until Durant ignited their closing rush in a 109-103 triumph.. Kendrick Perkins, Serge Ibaka and Nick Collison combined to hit 22 of 25 shots, as the Spurs struggled to contain the lesser Oklahoma City players.. You go into a game with a game plan and try to make other guys beat you, Collison said, when asked to consider what the Spurs were trying to do in Saturdays game. When other guys are able to step up and make shots, its tough to ...

They explained that the geyser was the increase in her entire energy system, speeding up, emotionally charged, sprawling outwards to her (perceived future.) The image of an (energetic) fish, which was her too, was her ability to fluidly move with the accelerations, swim within the speed of changes, take a breath as she goes. But with it, they also said she is morphing into her next expression of herself and all of life is morphing with her to express itself for her new form.. She obviously was a bookend to my first lady on the field that day. There was so much quantum physics involved in her reading, my head was splitting trying to keep up. With this lady, I heard the song clip its like thunder and lightening and then I could see this massive thunder ball, like the size of a beach ball, except it was an earthy tan color and kinda furry too. In the thunderclap, this thunder ball exploded and released itself 5 feet across her path (from west to east, we travel south to north) and there were so ...

This is a counter movement- a new era of Sport Fashion. The Puma Thunder Electric takes an unconventional approach to design that disrupts and commands attention. Its loud colour-blocking, material mixes and bright accents. It packs the power of a storm.. The Thunder pays homage to past collaborations and silhouettes ahead of their time. Inspired by 90s Cell System running silhouettes and the Puma x McQueen collaboration, the style is a reimagined pair of kicks with a bulky, unapologetic look and feel. The exaggerated tooling, the blown-up proportions and the loud color blocking reserve a spot for the Thunder on the international runways and streets.. #gallery-1 { margin: auto; } #gallery-1 .gallery-item { float: left; margin-top: 10px; text-align: center; width: 50%; } #gallery-1 img { border: 2px solid #cfcfcf; } #gallery-1 .gallery-caption { margin-left: 0; } /* see gallery_shortcode() in wp-includes/media.php */ ...

How is Theutates Thunder (gaming) abbreviated? TT stands for Theutates Thunder (gaming). TT is defined as Theutates Thunder (gaming) somewhat frequently.

Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is lacking. To elucidate the celastrol biosynthetic pathway and reconstruct it in Saccharomyces cerevisiae, we mined a root-transcriptome of Tripterygium wilfordii and identified four oxidosqualene cyclases and 49 cytochrome P450s as candidates to be involved in the early steps of celastrol biosynthesis. Using functional screening of the candidate genes in Nicotiana benthamiana, TwOSC4 was characterized as a novel oxidosqualene cyclase that produces friedelin, the presumed triterpenoid backbone of celastrol. In addition, three P450s (CYP712K1, CYP712K2, and CYP712K3) that act downstream of TwOSC4 were found to effectively oxidize friedelin and form the likely celastrol biosynthesis intermediates 29-hydroxy-friedelin and polpunonic acid. To facilitate production of friedelin, the

Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on the autoimmune disorders and simultaneously ineluctable hepatotoxicity and nephrotoxicity. Combinational application of Panax notoginseng (PN) and Rehmannia glutinosa (RG) weakens the toxicity of TW according the clinical application of traditional Chinese medicine. This article was aimed at the mechanism of decreasing toxicity of TW by the combinational application of PN and RG. Biochemical and pathohistological analysis were utilized to assess the toxicity on liver and kidney in rats administrated with TW, TW-PN, TW-RG and TW-PN-RG for 3 and 7 days ...

Looking for online definition of stealing thunder in the Medical Dictionary? stealing thunder explanation free. What is stealing thunder? Meaning of stealing thunder medical term. What does stealing thunder mean?

Rou Cong Rong is also known as Cistanches. The sweet, salty and warm herb has been used in TCM to treat, impotence, constipation, infertility, excessive uterine bleeding, yeast infection, high blood pressure, inflammation of the kidney, etc., as it tonifies the Kidneys, benefits the Yang, moistens the Intestines, Promotes bowel movement, etc. by enhancing the …. ...

Abstract:. Triptolide is the main bioactive molecule isolated from a root extract of Tripterigium wilfordii Hook F. of Celastraceae family. Chemically, it is a diterpenoid triepoxide molecule and its chemical formula is C20H24O6. Its five-membered unsaturated lactone ring (D-ring) is crucial for anti-tumor potential and carbonyl group at C-18 position is essential to exert important influence on the interaction between triptolide and the targeted protein(s). It is bio-synthesized from deoxy-D-xylullose-5-phosphate (DOXP) pathway in the cell. Triptolide can induce apoptosis in a number of breast cancer cells by up-regulating different pro-apoptotic and down-regulating different anti-apoptotic molecules. In vitro experiments indicate that it can down regulate several cell cycle related genes and induces S-phase cell cycle arrest. Triptolide treatment can also modulate the expression of different cell signaling molecules, e.g. ERK, NF-κB, FAK, VEGF, β-catenin, AKT etc. In vivo experiments ...

Only a year removed from the franchises first playoff appearance, the Oklahoma City Thunder performed like seasoned champions April 23.. The Thunder took a commanding 3-0 series lead in their best-of-seven matchup with the Denver Nuggets with an impressive 97-94 road win at the Pepsi Center in Denver. Maryland native and Oklahoma City superstar forward Kevin Durant led all scorers with 26 points, but it was a streaking Serge Ibaka layup that iced the game for the visiting Thunder. After Denver guard J.R. Smith swished a corner three-pointer in the closing seconds to cut Oklahoma Citys lead to 95-94, Ibaka streaked down the court for a easy, wide-open layup to push the Thunders lead to three points. Smith then hoisted up a contested three-point attempt to tie the game, but his desperation shot fell short-and with it, perhaps, the Nuggets chances of winning the series. To beat this team four straight times in a playoff [series] is not likely, Denver guard Aaron Afflalo told reporters after ...

Thunder Bay Tourism: TripAdvisor has 22,246 reviews of Thunder Bay Hotels, Attractions, and Restaurants making it your best Thunder Bay travel resource.

Book Holiday Inn Express & Suites Thunder Bay, Thunder Bay on TripAdvisor: See 203 traveller reviews, 55 candid photos, and great deals for Holiday Inn Express & Suites Thunder Bay, ranked #6 of 33 hotels in Thunder Bay and rated 4.5 of 5 at TripAdvisor.

Russ Brown Motorcycle Attorneys®; As a follow up to our recent blog on the Rolling Thunder® Inc. Ride for Freedom, we felt the need to share more information about Rolling Thunder® Inc. and the current Prisoners Of War (POW) and Missing in Action (MIA) this incredible organization is trying to help.. Rolling Thunder® began in 1987 when two Vietnam veterans, Artie Muller and Ray Manzo came together to discuss their concerns about the sightings of Americans who were reportedly alive and living in captivity. During Memorial Day weekend in 1988, many of these men along with their friends, families, and fellow veterans came together to form a First Amendment Demonstration Run involving approximately 2,500 people in Washington D.C. This motorcycle demonstration became known as the annual Ride for Freedom and this year marks the 25th anniversary of the event. Today, the number of spectators and participants in the annual Ride for Freedom has grown to an estimated 900,000. Rolling Thunder® Inc. ...

Welcome to the home of our Thunder Buddies podcast, named, in part, from Universal Studios highly-acclaimed comedy Ted, but inspired by our continued hope for wall-to-wall coverage of the Thunder. Below is our list of episodes (click the link to listen). If you prefer iTunes for your podcast listening experience, click here and subscribe. Hope you enjoy: Thunder Buddies -- 03/10 (<-Click Here) - Russell Westbrook detonated for a historic triple-double against the Clippers on Thursday night. What played into the performance. And theres been plenty of free agency chatter surrounding Kevin Durant of late? Legendary Thunder Buddy Darnell Mayberry joins the podcast to discuss.

Oklahoma City Thunder NBA basketball team, Thunder schedule, players roster, news & rumors, Chesapeake Energy Arena location, get tickets. Thunder Twitter, Facebook, Instagram, YouTube

Our knowledge of traditional Chinese herbal remedies is limited. Learn about traditional Chinese remedies during conventional cancer treatment.

A booming but joyous bellow sounded through the high ceilings at the Thunder Events Center this week. Seconds later, a grinning Hasheem Thabeet walked in to get fitted into his new Thunder gear. The 7-foot-3 Tanzanian center who joined the Thunder via free agency laughed, joked and asked questions throughout his introductory photo shoot, showing off the personable side of the former UConn Huskies standout who is entering his fourth season in the NBA. ...

Thunder Last Five: 4-1, W @ POR, W vs MIA, W vs MIN (2OT), W vs LAC, L @ UTA.. Tonight is almost assured to be an emotional evening for both the Lakers and their fans as Derek Fisher makes his return to Staples Center, this time as a member of the opposing team, which also happens to be the top team in the Western Conference, the Oklahoma City Thunder. With just 16 games left in the season, it may be increasingly difficult for the Lakers to catch Oklahoma in the standings. However, a victory tonight against a premium team like Oklahoma could give the Lakers an added boost with the playoffs looming. The Thunder have rolled on all cylinders as the season has progressed, and even embarrassed the Heat at home in a matchup that some predicted for the NBA Finals. Meanwhile, the Lakers trend of benching continued as Andrew Bynum saw just five minutes on the floor in the second half, scoring one point in the Lakers recent victory over Golden State. Will this trend continue tonight against the toughest ...

Thunder Tiger Pro 28 found in: THUNDER TIGER ENGINES PRO 28BD-R 28 Econo Power Manufacturer/Model By Series, THUNDER TIGER ENGINES PRO 28BD-R 28 MX..

It is time to Revitalize Downtown Fort William Thunder Bay - OPINION - As a teenager in Thunder Bay, living on the northside of the city, Fort William was the place to be. There were movie theatres, lots of restaurants, and some incredible shops in the downtown on Victoria Avenue, on May Street, and along Simpson Street. Then came Victoriaville and the downtown just seemed to start downward. Fast forward to right now. It is honestly sad to walk the streets of downtown Fort William. T

Shop Cyber Monday deals on Oklahoma City Thunder vintage clothing, hats and shirts at Fanatics. Find throwback looks in the latest Oklahoma City Thunder retro hats, t-shirts, jerseys and more from top brands at Fanatics today.

Issues with third party tickets, or tickets purchased through other online ticket resellers cannot be resolved by the Thunder Bay Community Auditorium.. When purchasing tickets online, be sure that the address in your browser starts with www.tbca.com or www.ticketmaster.ca There are a number of third party resellers who are also selling tickets to Community Auditorium events, including the Thunder Bay Blues Festival. Often, these resellers are charging a premium to purchase tickets through their sites.. ...

Ideal housing for guinea pigs are hutches approximately 0.9 sq metre per adult guinea pig, although they need plenty of exercise outside their hutch. Hutches and runs should ideally be placed out of the sun and sheltered from the rain and ideally hutches should be raised off the ground. In the winter, the hutch will have to be moved into a garage or outhouse.. Straw or wood shavings are ideal for guinea pigs in outdoor hutches and wet bedding should be removed on a daily basis. Hutches should be completely stripped out and scrubbed, ideally once a week during the summer and more regularly during the winter when guinea pigs spend more time inside. In the winter its also advisable to put plenty of hay in the hutch for your guinea pig to burrow in. ...

TY - JOUR. T1 - Wooden hutch space allowance influences male Holstein calf health, performance, daily lying time, and respiratory immunity. AU - Calvo-Lorenzo, M. S.. AU - Hulbert, L. E.. AU - Fowler, A. L.. AU - Louie, A.. AU - Gershwin, Laurel J. AU - Pinkerton, Kent E. AU - Ballou, M. A.. AU - Klasing, K. C.. AU - Mitloehner, F. M.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Dairy calves in the western United States are commonly raised individually in wooden hutches with a space allowance of 1.23 m2/calf. Recent legislative initiatives in California and across the United States were passed regarding concern over space allowance for farm animals. The objective of this study was to determine if rearing male Holstein calves in wooden hutches modified to increase space allowance would influence measures of performance, lying time per day, health, and respiratory immunocompetence. At 4 d of age, 60 calves were randomly assigned to 1 of 3 housing treatments: (1) conventional housing (CONV; 1.23 m2/calf), ...

Shop the best Thunder Ridge Emu Products 100% Pure Emu Oil 4 fl oz (112.50 mL) Liquid products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Thunder Ridge Emu Products 100% Pure Emu Oil 4 fl oz (112.50 mL) Liquid products.

Thunder Bays newest (and only) independent bookstore, Entershine, is now open for business. Understandably, the first question a visitor might have is, what is Entershine?. Its an old word, co-owner David Tranter answers as he rings up another sale during the book shops soft opening in July. Its the dappled light shining through leaves of trees. Or maybe its not a word, but it did show up in literature a couple of hundred years ago.. Whatever its origins, the name Entershine, on a carved wooden sign above the doorway, announces the arrival of Thunder Bays first independent bookshop since the closure of Northern Womans Bookstore in 2016.. Its the combination of opportunity, an ideal location, and our desire to do something meaningful for the city, Tranter says.. Theres a real trend in North America right now, a return to independent bookstores, co-owner Lynne Warnick chimes in during a zoom interview. We want to give back to the community, even though its a frightening ...

Rex Kalamian, (93, management and human resources) and former Bronco basketball player, is a candidate for the head coaching job of the Oklahoma Thunder. He most recently was with the LA Clippers under Coach Doc Rivers. He was lead assistant coach with the Thunder 2013-15.. This article was originally published by The Oklahoman on October 12, 2020.. ...

Voices call from the old days, Voices tell from the past, Ancient laws and ancient old ways to recast. (Voices opening number from Mythology) The show was filmed on location at the Helix Theatre in Dublin (where they filmed their debut show in 2007), its fitting that Celtic Thunder have chosen to return to their roots in order to film this musical odyssey back to the heart of the Celt. The opening number for Mythology is an original piece called Voices written expressly as an opener for the new show. Voices, quoted above, is collaboration between Celtic Thunder Musical Director David Munro and world-renowned composer Brendan Graham. Featuring New Tracks, see below for full track list. ...

It was a heartbreaking loss for the Oklahoma City Thunder [VIDEO] as they were beaten by the Minnesota Timberwolves [VIDEO] on a last second buzzer beater by #Andrew Wiggins.. Oklahoma Citys Carmelo Anthony hit a 3-pointer with 5.1 seconds left to give the Thunder the lead before the Timberwolves inbounded to Wiggins, who rushed up the court and got free with help from a crushing pick by Karl-Anthony Towns before pulling up for the victor.. Jamal Crawford scored all 17 of his points off the bench in the fourth quarter Friday night including a 3-pointer with 27 seconds left to clinch it. Karl Anthony-Towns contributed a double-double of 20 points and 10 rebounds.. Its the final play that will be remembered most, however, and it was one that could signal to the rest of the NBAs elite that Wiggins has arrived.. But how did Wiggins get so much space? That being said, pulling up on a dime from 30 feet out and using glass is no mean feat. But were also only three games into the season. Andrew ...

Thunder Jet is suitable for all age groups. Thunder Jet cruises at 30 knots (60kph) through our local sea conditions, giving its passengers a smooth and safe ride. The semi-sheltered waters of the Mamanuca group out from Denarau are the ideal conditions for everyone to enjoy Thunder Jet. Adverse conditions may create sidespray. Thunder Jets style and presence, offers a definite point of difference to other vessels operating from Denarau, with its superior speed and maneuverability. Camera phones and other devices are welcome but must be used at your own risk. Your tour includes complimentary bottled water for everyone on board. Thunder Jet is MSAF Surveyed for the Mamanuca island group with certified captain and crew to take good care of everyone on board. Thunder Jet is also available for group transfers, private charters and special events. Advanced bookings are essential and subject to availability). Cancellation Policy, Terms & Conditions are available here ...

Thunder Bay, Ontario, The Port of Thunder Bay is reporting strong cargo volumes at the end of June. Shipments of Prairie grain, the ports primary commodity, remained ahead of last years pace in June, continuing a three-month trend. Lake Superior News

Duana is raising four grandchildren; her daughter died in 2008, and the childrens father is not in the picture. A Thunder staffer who was helping her shop said the hardest part of the experience was getting Duana to spend something on herself, rather than using all the money for her grandkids. She took quite a bit of convincing, but finally selected at least a few things she could enjoy ...

Three more colorways of the Air Jordan 2 Decon will be dropping this summer, as its going to be available in triple black, sail and this thunder blue finish. The lifestyle updated sneaker features a suede upper instead of its traditional leather makeup, with tonal leather detailing seen on the wings branded tongue, Nike branded The post Release Date: Air Jordan 2 Decon Thunder Blue appeared first on KicksOnFire.com.

Totem Acoustics Thunder for sale. Thunder sub Is equally at home with stereo or home theatre. Totem is well known for offering fantastic sound quality at prices below competing products of similar quality. 10 sealed design woofer ...

O Thunder Bay Chill foi fundado em 2000 Tony Colistro com o objetivo de levar a Thunder Bay o futebol de alta qualidade.[2] Ainda no ano de 2000 a equipe estreia na PDL, ficando em último da Divisão Heartland e sendo eliminado na primeira fase.[3]. Em 2008 a equipe se sagra campeã da Premier Development League ao vencer nos pênaltis o Laredo Heat na final. A partida ocorreu em Laredo, Texas no dia 9 de agosto de 2008.[4]. Em 2010 a equipe volta a disputar a final, porém é derrotada pelo Portland Timbers U-23. Em 2013 é derrotado novamente na final pelo Austin Aztex. Em 2017 consegue chegar a final, mas pela terceira vez é derrotado e fica com o vice-campeonato, perdendo dessa vez para o Charlotte Eagles.[4]. ...

Screenshots zum Actionspiel Thunder Wolves auf GamePro.de. Immer auf dem neuesten Stand: Unsere Bilder-Galerie zeigt, wie Thunder Wolves wirklich aussieht.

Guinea pigs really give so much to our lives, from their adorable popcorn jumps, to their cosy cuddles. The list goes on, which is why want to give em plenty of space for it all, at home. That said, guinea pigs arent really best for bedsit living. And although a small home or apartment would work fine, the three-bedroom-house-with-backyard situation is truly home-squeak-home, for these compact creatures. Ahhh… Hutch sweet hutch. Because big is best for your furry friend, its wise to move him into a hutch. A hutch is a cage divided into two connecting compartments. Just how big youll want it to be will depend on the number of guinea pigs you adopt: Number of guinea pigs Preferred size of hutch 1 1.0 sqm 2 1.0 sqm 3 1.2 sqm 4 | 1.2 sqm What makes a good hutch? Definitely a covered section that will make your cuddly companion feel safe and protected, while he sleeps. Your American Short Coats hutch should also be lined with soft grass or hay - but not straw, sawdust or wood shavings, gosh darn

This page provides guidance for Fred Hutch investigators generating or using flow cytometry data, and who may be using the Fred Hutch Flow Cytometry Shared Resource.

Furniture / Desks / Credenza & Hutch Combos- Contemporary / COMBO02 KIT | ALPHA PROPS | Furniture / Desks / Credenza & Hutch Combos- Contemporary / COMBO02 KIT movie props and set dressing available at Alpha Medical Resources

For a stylish and easy to clean home look no further than the Eglu Go Guinea Pig Hutch, while the Outdoor Guinea Pig Run is ideal for offering your pets even more space. Make your pet squeal with delight with the awesome Zippi Guinea Pig Tunnels - use them to connect a hutch to a run or to build a network of play tunnels. Omlet also has a great selection of Guinea Pig Toys, Guinea Pig Food and Guinea Pig Treats.

If you are a fan of Greek-inspired slot machines then read our Zeus God of Thunder slot review ✔️ Learn all about the game features, bonuses and jackpots.

A quick look at 5 important Chinese herbs, this functions, and why you should care in todays guest post. As more individuals grow tired of the side effects involved with taking conventional prescription medications, and even over-the-counter medications, for a variety of acute and chronic ailments

TRENTON The baseball gods must have wanted to see CC Sabathia make his rehab start for the Thunder on Wednesday night against the Portland Sea Dogs.

Health,Researchers in Hong Kong are observing the effect of Chinese herbal ex...They have so far recruited 75 patients with either breast or colon......,Chinese,herbal,remedies,aids,in,cancer,treatment,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

Sometimes, a cough is the most annoying symptom and it lingers for weeks even after the cold has cleared. This is because the airways may still be inflamed and sensitive. Chinese Medicine claims that the common cold is associated with lung dysfunction. When coughing becomes a major complaint, it means the pathogens have disturbed qi activities inside the lungs, therefore physicians will aim to K

Cacao, Theobroma cacao, is a tropical evergreen tree in the family Byttneriaceae. It is native to Central and South America and is cultivated extensively for its seed, which is the source of COCOA, CHOCOLATE, and cocoa butter. Cacao is a wide-branched evergreen that grows up to 7.5 m (25 ft) tall and bears seedpods up to 30 cm (1 ft) long and 10 cm (4 in) thick, with a hard leathery shell. Pods contain as many as 40 seeds, or beans, some up to 2.5 cm (1 in) wide. Several species of Theobroma are cultivated in tropical America. The principal species used for cocoa, is grown throughout the wet, lowland tropics, especially in south-east Asia, South America, and West Africa, where the trees are planted under the shade of taller trees. They usually bear fruit 4 years after they have been planted. Workers harvest cacao beans with knives. After extraction from the fruit, the beans are placed in piles, covered with banana leaves, and allowed to ferment; afterward they are dried to prevent moulding. They ...

He eventually sought therapy on sexual function and blood thunder viagra have included the use of vacuum pumps used as a result of an intrapsychic, relational, genetic, or medical condition, an organic etiology. Tgf-1 induces the cavernous vein, artery, and vein. Comment: There is evidence, however, to adapt more successfully to what degree pde4 inhibitors (sildenafil, tadalafil, and vardenafil), represent first-line interventions over several weeks. Randomized, controlled, double-blind studies using college samples typically find few associations between cardiovascular disease and 26% female. Urology 1972; 2(1):8152. Jama 2002; 308(5):835890. Although in this area, exceptions include the clinically evident notion276 male sexual behavior 51 the males erectile dysfunction. This suggests three possible scenarios for the moment, an assessment of (1) a deficiency or absence of other sexual disorders exerted by supraspinal projections on sexual issues in therapy, and radiation therapy national cancer ...

At Thunder Bay Regional Health Sciences Centre (the Hospital), onsite parking will be made available in an equitable way to all users of the Hospital.

Thunder Bay, Ontario, August 9, 2019 - Thunder Bays Rapid Access Addiction Medicine Clinic (RAAM Clinic) was recently awarded a Transformative Change Award 2019 by the Alliance for Healthier Communities at a national Community Health Connections conference in Ottawa.. The RAAM Clinic is a collaboration of seven community partners providing addictions medicine and client supports for individuals with substance use issues. Launched in 2018, the RAAM Clinic aims to tackle Thunder Bays elevated rates of opioid and alcohol abuse, and support overdose prevention as a community-wide effort.. The RAAM Clinic is offered through two main sites in Thunder Bay at NorWest Community Health Centres and St. Josephs Care Groups Balmoral Centre. Individuals aged 16 years and over can access services at any time through health care provider referral or without an appointment as a self-referral or on a walk-in basis.. Says Juanita Lawson, CEO of NorWest Community Health Centres; There are several clinical and ...

Explore Hidden Valley Picnic in Medicine Bow-Routt Nfs & Thunder Basin Ng, Wyoming with Recreation.gov. Hidden Valley Group Picnic Site offers a large open space, surrounded by scenic forests, for groups of up to 300 people to gather amidst a beautiful outdoor set

The CILU 102.7 FM Hip Hop(Thunder Bay, ON)for the week ending February 22, 2011; !earshot magazine features campus/community radio charts, cd reviews, articles and interviews, label profiles and more.

Nerlens Noel was the Thunders closing center Tuesday night in a 112-107 loss to the Lakers. Starting center Steven Adams sat on the bench.

BINDING EFFECT. This is a binding agreement between you and . Sussex Thunder AFC . (us, we, Company). By using the Internet site located at https://sussexthunder.com . (the Site), you agree to abide by these Terms of Use. If at any time you find these Terms of Use unacceptable, you must immediately leave the Site and cease all use of it.. PRIVACY POLICY. We respect your privacy and permit you to control the treatment of your personal information. A complete statement of our current privacy policy can be found by clicking here. Our privacy policy is expressly incorporated into this Agreement by this reference.. MINIMUM AGE. You must be at least 14 years old to access and participate on this site. You guarantee and warrant you are at least 18 years old and are able to enter into this Agreement from a legal perspective.. EBOOK SIGNUPS AND MAILINGS. You have the option, but not obligation, to sign up and receive a free eBook from us. Should you do so, you are agreeing to receive further ...

BINDING EFFECT. This is a binding agreement between you and . Sussex Thunder AFC . (us, we, Company). By using the Internet site located at https://sussexthunder.com . (the Site), you agree to abide by these Terms of Use. If at any time you find these Terms of Use unacceptable, you must immediately leave the Site and cease all use of it.. PRIVACY POLICY. We respect your privacy and permit you to control the treatment of your personal information. A complete statement of our current privacy policy can be found by clicking here. Our privacy policy is expressly incorporated into this Agreement by this reference.. MINIMUM AGE. You must be at least 14 years old to access and participate on this site. You guarantee and warrant you are at least 18 years old and are able to enter into this Agreement from a legal perspective.. EBOOK SIGNUPS AND MAILINGS. You have the option, but not obligation, to sign up and receive a free eBook from us. Should you do so, you are agreeing to receive further ...