TY - JOUR. T1 - The effect of trimethoprim on potassium and uric acid metabolism in normal human subjects. AU - Don, Burl R. PY - 2001. Y1 - 2001. N2 - Background: Trimethoprim used in combination with other antibiotics, has been implicated in causing hyperkalemia and hypouricemia in patients with acquired immune deficiency syndrome (AIDS). In experimental animal models, trimethoprim has been demonstrated to block sodium channels and Na+-K+-ATPase in the distal nephron and thus impair potassium excretion. Although the data from the experimental models suggest that trimethoprim reduces urinary potassium excretion, the retrospective clinical studies have confounding factors that prevent a rigorous demonstration that the hyperkalemia and hypouricemia are due solely to the effects of trimethoprim on solute excretion. Aim: The purpose of this study was to evaluate the effect of trimethoprim on potassium and uric acid balance in normal human subjects. Methods: Five normal human subjects were admitted ...
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Fifty strains of Branhamella catarrhalis were examined for susceptibility to sulphamethoxazole, trimethoprim and a combination of the two by determinating minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs). All strains were susceptible to sulphamethoxazole and resistant to trimethoprim. On the basis of the MIC results it was predicted that greater synergy between sulphamethoxazole and trimethoprim would be observed with approximately equal proportions of each component. The lowest FIC values were obtained with a ratio of 1:1 and the greatest synergy was observed at this ratio with 39 strains (78%). Only seven strains were most synergistically inhibited at the ratio of 20:1 (sulphamethoxazole: trimethoprim) although this ratio was still synergic for most strains. Overall the 1:20 ratio was not synergic.. ...
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Folate. Supplementation Likely Helpful. Both trimethoprim and sulfamethoxazole interfere with folate: The sulfamethoxazole makes it hard for invading bacteria to manufacture folate, and the trimethoprim makes it hard for bacteria to use the folate. The net effect is to starve the bacteria of this necessary vitamin.. Humans and other mammals are much less affected by these antibiotics than are bacteria, due to the different way we process folate. However, trimethoprim can still interfere to some extent in your bodys ability to utilize this essential nutrient. Folate supplementation may be helpful if you take this antibiotic for a long period of time (to prevent urinary tract infections, for example).1 ...
An HPLC method was developed for rapid determination of trimethoprim in additive premixes, in final fodders, and in contaminated final fodders. Trimethoprim is extracted from the sample with acidified aqueous methanol or dichloromethane and, after dilution of the methanolic extract or purification of the dichloromethane extract by re-extraction into 0.15 mol.l-1 H2SO4 and on the solid phase C18, it is determined by reverse-phase chromatography on C18 with UV detection. The composition of the mobile phase was optimized. The limit of determination (2 mg.kg-1) and the yield of the method at trimethoprim concentrations 15 - 45 mg.kg-1 (99.4 ± 5.7 %) were determined. The repeatability was not determined due to a low number of real samples of final fodders. To lower the limit of determination, fluorescent detection was used after precolumn derivatization of trimethoprim with phthalaldehyde. The calculated limit of detection was then 15 µg.kg-1 ...
The standard oral regimen based on trial evidence is Trimethoprim - Sulfamethoxaxole ( TMP-SMX ) plus Doxycycline. This regimen is used in Thailand but is associated with side-effects and poor adherence by patients, and TMP-SMX alone is recommended in Australia ...
Trimethoprim inhibits dihydrofolate reductase, most efficaciously effecting the bacterial enzyme. Bacteria are unable to uptake folate appreciably from rich medium and so must synthesize it themselves. Addition of folate to the medium can counteract trimethoprim, however. Sulfonilamide effects another step in folate metabolism and so exibits a synergistic effect when used with trimethoprim. ...
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Folates are a class of metabolites that are essential to living cells across all life. Because these molecules are especially important in aiding cell division, folates are targets for antibiotics, such as trimethoprim. I aim to model the pathways of folate production and interconversion in Escherichia coli. I began my work by assessing a previously published mathematical model of the E. coli folate pathways, published by Kwon and Rabinowitz, which explored the effects of trimethoprim on the system. I explored the model in depth and found avenues for improvement. My model produced enhancements in accuracy and laid the foundation for future work. In the future, this model can be expanded further and be used to model a variety of other experimental conditions under the effect of trimethoprim ...
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Trimethoprim with sulfamethoxazole is a important drugs, but we also need to pay attention to the trimethoprim sulfamethoxazole side effects.
Trimethoprim, 0.1 ml. Trimethoprim, (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine), is a pyrimidine inhibitor of dihydrofolate reductase and is an antibacterial related to pyrimethamine.
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Nominated Substances: Trimethoprim/sulfamethoxazole (commercial). Nomination Date: 01/29/1992 Nominator: NCI Rationale: Significant human exposure as extensively used drug for treatment of urinary tract infections and pneumonia caused by p. Carinii (PCP) and its potential use in AIDS patients with PCP. NTP Principles: Pre 1993 - 2, 3, 8 Status: Selected ...
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Similarly, this medicine is also the combination of the two different chemicals trimethoprim and sulfamethoxazole. These both of the chemicals are antibiotics and help to reduce the any infection produced due to the bacteria.
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Trimethoprim (trye-METH-oh-prim) Treats infections, including urinary tract infections and ear infections. Brand Name(s): Primsol, Trimpex Solution
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Trimethoprim allergy. Extensive rash over the back and arms of a 65-year-old woman due to an allergic reaction to trimethoprim. Trimethoprim is an antibiotic drug commonly used to treat urinary tract infections, prostatitis and bronchitis. Reaction to the drug has produced a rash consisting of numerous circular or irregular red spots which may be itchy. Rash may be accompanied by fever, sore throat, headache or diarrhoea. Treatment of such drug reactions involves withdrawal of the causative drug. Corticosteroid drugs can be given to reduce inflammation and irritation. - Stock Image M320/0218
Background: Trimethoprim is considered as a trimethoxy benzyl pyrimidine, the action mechanism of which is to block the synthesis of tetrahydrifolate. Sulfamethoxazole is an antibacterial drug from the sulfanamide group, this drug prevents from synthesis of dihydrofolic acid. Trimethoprim which is consumed along with sulfonamide controls the metabolic oxidants which in ...
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