The induction of sister chromatid exchanges (SCEs) by triethylenemelamine (51183) (TEM) was studied in mice and hamsters. Male CD1-mice and Chinese-hamsters were injected intraperitoneally with 0 to 405 micrograms per kilogram (microg/kg) TEM. Twenty hours later they were killed and femurs, tibiae and spleens were removed. The marrow was flushed out of the femurs and tibiae. The bone marrow and sp
0064] Numerous chemotherapeutic agents (antineoplastic agents) have been developed for treating cancer. In the clinic, depending on cancer diagnosis, different antineoplastic agents are preferred. Antineoplastic agents used for treating cancers, or under investigation for use in treating cancers, may include, but are not limited to: (1) nitrogen mustards, such as mechlorethamine, cyclophosphamide, ifosfamide, melphalan (L-sarcolysin, L-PAM), uramustine, and chlorambucil; (2) ethylenimines and methylmelamines (aziridines), such as thioTEPA, hexamethylmelamine (HMM, altretamine), and triethylenemelamine (TEM); (3) nitrosoureas, such as carmustine (BCNU), lomustine (CCNU), semustine (Methyl-CCNU), fotemustine, and streptozotocin; (4) alkyl sulfonates, such as busulfan; (5) azines and hydrazines (triazenes), such as dacarbazine (DTIC) and procarbazine (MATULANE®); (6) platins, such as cisplatin, carboplatin and oxaliplatin; (7) pteridines, such as methotrexate; (8) pyrimidine analogs, such as ...
Parkinson's disease has officially been linked to the exposure to pesticides by a Decree dated 4 May 20121. It did not take long after the enactment…
Although the sperm precursors never became fully mature sperm, they developed far enough to fertilize eggs. They were injected into 379 eggs; nine baby mice…
To the editor: Sex hormones appear to influence the immune system; for example, after immunization, women have higher immunoglobulin levels and a greater capacity for producing antibodies than men (1). The sex hormone modulation of cellular immune responses may be of pathophysiologic and perhaps therapeutic importance, because in the NZB/NZW/BFI mouse lupus model, castration of the male accelerates the disease and administration of estrogens to the castrated males accelerates the disease still further (2). Recently, we reported the presence of androgen receptors in 13 biopsy specimens of non-Hodgkins malignant lymphomas (3). Because danazol is an impeded androgen and antiestrogen with ...
test. Glycyrrhetinic Acid inhibited the mutagenic activity of benzo[a]pyrene and inhibited tumor initiation and promotion by other agents. Glycyrrhizic Acid inhibited tumor initiation by another agent, but did not prevent tumor promotion.. Ammonium Glycyrrhizate was not genotoxic in cytogenetics assays, the dominant lethal assay, a bacterial assay and heritable translocation tests. Disodium Glycyrrhizate was not carcinogenic in a drinking water study at exposure levels up to 12.2 mg/kg/day for 96 weeks. Glycyrrhizate salts produced no reproductive or developmental toxicity, except for a dose-dependent increase in a skeletal variation (at 238.8 and 679.9 mg/kg/day) in one study. Sedation, hypnosis, hypothermia, and respiratory depression were seen after administration of 1250 mg/kg Glycyrrhetinic Acid intraperitoneally.. No treatment related effects in motor function tests were seen after exposure to a powdered diet containing up to 4% Ammonium Glycyrrhizate, but active avoidance was facilitated ...
Sulfur mustard (SM), an alkylating chemical warfare agent, leads to tissue damage, including inflammation, blister formation, and impaired wound healing. Especially wound healing is of concern because after SM exposure, wound healing is prolonged. In this study, we focused on the effect of SM (30 and 100μM) on endothelial tube formation, apoptosis, and proliferation in mouse embryoid bodies (EBs), which provide an appropriate model for investigating vasculogenesis and angiogenesis. EBs were exposed to SM for 30 min on day 0, 3, or 6 of EBs growth, were allowed to grow until day 7, then fixed, and immunostained (PECAM-1, Ki67, and activated caspase-3). SM significantly decreased endothelial tube formation compared with unexposed EBs. Additionally, we observed a significant increase of apoptosis. As the formation of reactive oxygen species (ROS) is discussed to be involved in the pathophysiology of SM toxicity, we evaluated the effect of ROS scavengers (α-linolenic acid [ALA] and N-acetyl ...
We have evaluated the usefulness of bilateral rather than unilateral posterior iliac spine trephine biopsies in searching for lymphoma and other neoplastic diseases in the bone marrow. Two hundred and eighty-two patients with these diseases were studied. Tumor was found on only one side in 22% of patients with non-Hodgkins malignant lymphoma, in 43% of patients with Hodgkins disease, and in 36% of patients with other neoplastic processes. Thus, the second biopsy yields an additional 11% to 22% of positive biopsies. We conclude that bilateral trephine bone marrow biopsies should be routinely performed when searching for tumor in the bone marrow. ...
Zach Reagle, DO, Pulmonologist Over the last few months there have been multiple media reports of a mysterious lung disease caused by vaping. At the time of