We demonstrate trapping and characterization of multiple gold nanospheres with a setup composed of dark field imaging and optical tweezers. The number of trapped nanospheres is quantified by the overall dark-field scattering intensity. The spectra of the scattering intensity show that there is no interparticle coupling among trapped nanospheres when the density of nanospheres in the trap is low enough (less than 10 particles), while the density of nanosphere increases the interparticle coupling of nanospheres becomes obvious. In addition, the trapping potential of a single gold nanosphere is obtained by trapping an ensemble of gold nanospheres.. ©2013 Optical Society of America. Full Article , PDF Article ...

Aim: To investigate the preparation, in vitro release, in vivo pharmacokinetics and tissue distribution of a novel polymeric micellar formulation of paclitaxel (PTX) with Pluronic P123. Methods: The polymeric micelles of paclitaxel with Pluronic P123 were prepared by a solid dispersion method. The characteristics of micelles including particle size distribution, morphology and in vitro release of PTX from micelles were carried out. PTX-loaded micellar solutions were administered through the tail vein to healthy Sprague-Dawley rats and Kunming strain mice to assess the pharmacokinetics and tissue distribution of PTX, respectively. Taxol, the commercially available intravenous formulation of PTX, was also administered as control. Results: By using a dynamic light scattering sizer and a transmission electron microscopy, it was shown that the PTX-loaded micelles had a mean size of approximately 25 nm with narrow size distribution and a spherical shape. PTX was continuously released from Pluronic ...

Export Data And Price Of Methoxypolyethylene Glycol , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of Methoxypolyethylene Glycol Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India Methoxypolyethylene Glycol Export data. You can find previous two days Methoxypolyethylene Glycol Export data on Eximpulse Services. Methoxypolyethylene Glycol Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for Methoxypolyethylene Glycol Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected]. Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have ...

TY - JOUR. T1 - Evaluation of Microneedles-assisted in situ Depot Forming Poloxamer gels for Sustained Transdermal Drug Delivery. AU - Khan, Samiullah. AU - Usman Minhas, Muhammad. AU - Tekko, Ismaiel A.. AU - Donnelly, Ryan F.. AU - Thakur, Raghu. PY - 2019/1/23. Y1 - 2019/1/23. N2 - In this study, for the first time, we have reported a sustained transdermal drug delivery from thermoresponsive poloxamer depots formed within the skin micropores following microneedle (MN) application. Firstly, we have investigated the sol-gel phase transition characteristics of poloxamers (PF®127, P108, and P87) at physiological conditions. Rheological measurements were evaluated to confirm the critical gelation temperature (CGT) of the poloxamer formulations with or without fluorescein sodium (FS), as a model drug, at various concentrations. Optimized poloxamer formulations were subjected to in vitro release studies using a vial method. Secondly, polymeric MNs were fabricated using laser-engineered silicone ...

Fabrication and Properties of Polyethylene Glycol-Modified Wood Composite for Energy Storage and Conversion. Yun Li,a Xianjun Li,a,* Dandan Liu,b Xiyi Cheng,a Xia He,a Yiqiang Wu,a Xingong Li,a and Qiongtao Huang c. Green fir wood (Pseudotsuga menziesii) was modified with polyethylene glycol (PEG) to produce wood composites for energy storage and conversion. The PEG-modified wood composites were evaluated based on their dimensional stability, durability, and thermal properties by various analytical methods. The differential scanning calorimetry (DSC) results showed the melting temperature and the latent heat of the phase change material (PCM) composite were 26.74 °C and 73.59 J/g, respectively. Thermal cycling tests and thermogravimetric analysis confirmed the composite exhibited good thermal stability, reliability, and chemical stability. All treated specimens were free from noticeable defects, and the addition of a surface varnish coating prevented PEG from leaching. The PEG-modified ...

A coordination polymer is an inorganic or organometallic polymer structure containing metal cation centers linked by organic ligands. More formally a coordination polymer is a coordination compound with repeating coordination entities extending in 1, 2, or 3 dimensions. It can also be described as a polymer whose repeat units are coordination complexes. Coordination polymers contain the subclass coordination networks that are coordination compounds extending, through repeating coordination entities, in 1 dimension, but with cross-links between two or more individual chains, loops, or spiro-links, or a coordination compound extending through repeating coordination entities in 2 or 3 dimensions. A subclass of these are the metal-organic frameworks, or MOFs, that are coordination networks with organic ligands containing potential voids. Coordination polymers are relevant to many fields such as organic and inorganic chemistry, biochemistry, materials science, electrochemistry, and pharmacology, ...

TY - JOUR. T1 - Chlorophyll derivatives as catalysts and comonomers for atom transfer radical polymerizations. AU - Gajewska, Bernadetta. AU - Raccio, Samuel. AU - Rodriguez, Kyle J.. AU - Bruns, Nico. PY - 2019/1/7. Y1 - 2019/1/7. N2 - Copper trisodium chlorophyllin is obtained from natural chlorophyll, and is widely used as a major green food colorant in cosmetics and in medical devices. Copper chlorophyllin also proves to be an efficient catalyst and comonomer for atom transfer radical polymerizations (ATRP). Aqueous ATRP of poly(ethylene glycol) acrylate (PEGA) results in PEGA-chlorophyllin copolymers with narrow molecular weight distributions and a controlled content of chlorophyllin. The reactions proceed with first order kinetics, and the polymer's molecular weight increases with conversion. The resulting copolymers could find application in drug delivery and in biomedical materials, or as solar energy harvesting materials. In order to suppress the incorporation of the catalyst into the ...

How is Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles) abbreviated? CMC stands for Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles). CMC is defined as Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles) rarely.

The global Water Soluble Polymer Market size is expected to value at USD 43.79 billion by 2022. The market is subject to witness a substantial growth due to the rise in the number of application of water soluble polymers in drilling, enhanced oil recovery, mining, wastewater treatment, and food. Increasing adoption of water-soluble polymers as stabilizing agents, thickeners, film formation agent, emulsifiers, rheology modifiers, lubricity aids, and conditioners, are expected to fuel market demand for water soluble polymers over the forecast period. Globally, the water soluble polymers industry is predicted to grow at higher CAGR in the forecast period, providing numerous opportunities for market players to invest for research and development in the water soluble polymers market.. Water soluble polymers are vital for production of various household products, detergents, personal care, and paints & coatings. Increasing adoption of water soluble polymers in food & beverages industry, building & ...

PRIMARY OBJECTIVE:. I. To evaluate the complete response (CR) + near-complete response (nCR) rate of the bortezomib/pegylated liposomal doxorubicin (pegylated liposomal doxorubicin hydrochloride) regimen in patients with previously untreated, symptomatic multiple myeloma.. II. To evaluate the toxicity of the bortezomib/pegylated liposomal doxorubicin regimen in patients with previously untreated, symptomatic multiple myeloma.. SECONDARY OBJECTIVES:. I. To evaluate the overall response rate, including patients with CR, nCR, and partial response (PR), of the bortezomib/pegylated liposomal doxorubicin regimen in patients with previously untreated, symptomatic multiple myeloma.. II. To evaluate the impact of therapy with the bortezomib/pegylated liposomal doxorubicin regimen on the ability to collect peripheral blood stem cells in those patients going on to subsequent autologous stem cell transplantation.. III. To evaluate the time to progression (TTP) in all patients receiving bortezomib/pegylated ...

TY - JOUR. T1 - Surface-initiated reversible addition-fragmentation chain transfer polymerization of chloroprene and mechanical properties of matrix-free polychloroprene nanocomposites. AU - Zheng, Yang. AU - Abbas, Zaid M.. AU - Sarkar, Amrita. AU - Marsh, Zachary. AU - Stefik, Morgan. AU - Benicewicz, Brian C.. N1 - Funding Information: We acknowledge the support from the SC SmartState program . AS and ZM acknowledge partial support of their work as Leon Shechter graduate fellows. This work made use of the South Carolina SAXS Collaborative, supported by the NSF Major Research Instrumentation program ( DMR-1428620 ). Publisher Copyright: © 2017. PY - 2018/1/17. Y1 - 2018/1/17. N2 - RAFT polymerization and surface-initiated RAFT polymerization (SI-RAFT) of chloroprene was studied. The SI-RAFT polymerization rate of chloroprene was found to be slower than free solution RAFT polymerization, and further regulated by the graft density of grafted polymers. The resulting polychloroprene-grafted ...

Three brønsted acidic ionic liquids, 1-methylimidazolium acetate ([Hmim][CH3COO]), 1-methylimidazolium propionate ([Hmim][CH3CH2COO]) and 1-methylimidazolium butyrate ([Hmim][CH3CH2CH2COO]) were used as reaction medium for atom transfer radical polymerization of methyl methacrylate with ethyl 2-bromoisobutyrate (EBiB)/CuBr as the initiating system. Kinetic studies, chain extension and block copolymerization confirmed the well-controlled manner of these polymerizations in three brønsted acidic ionic liquids. The reactions were fast and the polydispersities of the polymers were quite narrow (1.10,Mw/Mn,1.34). The rate of polymerization in [Hmim][RCOO] decreased with the increasing alkyl chain lengths (n from 1 to 3), indicating a strong dependence of reaction rate on the length of the substituted groups of the anions in ionic liquids. ...

This study investigated the effect of pegylated interferon (alfa 2a and alfa 2b) plus ribavirin in chronic hepatitis C patients with mixed genotype 1 and 2.

Studies on a model ink suspension have shown that the effect of non-ionic dispersion agents on ink agglomeration using fatty acid chemistry as collector was highly temperature-dependent. The non-ionic surfactant reduced the agglomeration efficiency at low temperatures (below the cloud point of the surfactant) but this negative effect was reduced at increasing temperatures. At temperatures above the cloud point the non-ionic surfactant improved the agglomeration. The non-ionic surfactant adsorbs to both the ink and precipitated soap particles, which at low temperatures resulted in an increased colloidal stability of the particles but at higher temperatures led to a destabilisation of the particles due to the increased hydrophobicity of the surfactant. The surfactants clearly affected the precipitation of fatty acid anions to calcium soaps and at very high surfactant concentrations the formation of calcium soap particles was drastically reduced. The most favourable conditions seemed to be ...

TY - JOUR. T1 - Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease. T2 - A randomized controlled trial. AU - Orringer, E. P.. AU - Casella, J. F.. AU - Ataga, K. I.. AU - Koshy, M.. AU - Adams-Graves, P.. AU - Luchtman-Jones, L.. AU - Wun, Theodore. AU - Watanabe, M.. AU - Shafer, F.. AU - Kutlar, A.. AU - Abboud, M.. AU - Steinberg, M.. AU - Adler, B.. AU - Swerdlow, P.. AU - Terregino, C.. AU - Saccente, S.. AU - Files, B.. AU - Ballas, S.. AU - Brown, R.. AU - Wojtowicz-Praga, S.. AU - Grindel, J. M.. PY - 2001/11/7. Y1 - 2001/11/7. N2 - Context: Sickle cell disease (SCD) can cause severe painful episodes that are often thought to be caused by vaso-occlusion. The current therapy for these uncomplicated painful episodes includes hydration, oxygen, and analgesics. Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD. Objective: To compare the ...

Page contains details about polyvinylidene fluoride/carbon black/hollow Ge nanospheres . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Nanocomposite Materials: Effect of Freezing and Thawing Process on Betamethasone Acetate Release from Polyvinyl Alcohol Nanospheres

Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and galbanic acid (Gal), dissolved in DMSO against the murine C26 and human Caco-2 colon carcinoma cells. Further, curcumin potential for cisplatin and doxorubicin (Dox) co-therapy was studied. Materials and Methods: The combined cytotoxic effect of these phytochemicals at varying dose ratios were examined using the MTT colorimetric assay. Moreover, the time-dependent toxicity of curcumin, cisplatin, Dox, and pegylated liposomal Dox (Doxil) was determined. The interactive anti-proliferative behavior of these compounds was examined using the CompuSyn software. Results: Nanomicellar curcumin showed considerable cytotoxicity in C26 cells 24 hr post-treatment. Co-treatment of cells with curcumin nanomicelles: Gal had a synergistic effect in C26 (at 10:1 molar ratio), and Caco-2 (at 1:5 molar ratio) cell lines in cell cultures. Nanomicellar curcumin showed strong and mild ...

The cloud points (CP) of 1 g/dl solutions of polyethylene oxide-polypropylene oxide (PEO-PPO) based triblock copolymers (Pluronics® P84, L64, L44 and Reverse Pluronics® 10R5, 25R4, 17R4) were measured as a function of their molecular weight and added ionic surfactant. For identical PEO/PPO ratios, copolymers with lower molecular weight show a larger increase in the cloud point in the presence of surfactants than polymers with higher molecular weight. The opposite trend has been observed for reverse Pluronics. The cloud points of polymers with different PEO/PPO ratios have also been reported. An increase in the size of the middle PEO block in reverse Pluronics has a more significant effect on cloud points than molecular weight increment. Ionic surfactants produced marked increases in the cloud points of copolymer solutions. The effect was much larger for surfactants with higher hydrophobicity. Cationic surfactants with different chain lengths were used to examine the surfactant-polymer ...

TY - JOUR. T1 - Polymeric catenanes synthesized via "click" chemistry and atom transfer radical coupling. AU - Bunha, Ajaykumar. AU - Cao, Peng Fei. AU - Mangadlao, Joey. AU - Shi, Fei Mo. AU - Foster, Edward. AU - Pangilinan, Katrina. AU - Advincula, Rigoberto. PY - 2015/5/1. Y1 - 2015/5/1. N2 - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. AB - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. UR - ...

Volume 21, Issue 1, pages 42-52, January 2014. Original Article. U. Mihm1,†, M.-W. Welker1,†, G. Teuber2, H. Wedemeyer3, T. Berg4, C. Sarrazin1, S. Böhm4, U. Alshuth5, E. Herrmann6, S. Zeuzem1,*. Article first published online: 21 JUN 2013. DOI: 10.1111/jvh.12124. © 2013 John Wiley & Sons Ltd. Abstract. Keywords: IL28B genotype; ribavirin monotherapy; ribavirin priming; viral kinetics. Summary. Ribavirin amplifies the interferon-alpha (IFN) signalling cascade. As ribavirin needs 4 weeks to reach steady state, ribavirin priming may optimize hepatic IFN sensitivity before starting a pegylated (PEG)-IFN/ribavirin combination therapy. This study investigated potential benefits of ribavirin priming prior to PEG-IFN2a/ribavirin combination therapy on viral kinetics, on-treatment and sustained virological response (SVR) in chronic hepatitis C virus (HCV) genotype 1 infection. Sixty-eight treatment naive patients were randomized 2:2:1 to ribavirin (ribavirin arm) or placebo (placebo arm) or ...

To determine the efficacy of treatment with 8 weeks of entecavir followed by 40 weeks of both entecavir and peginterferon in the treatment of chronic hepatitis B in hepatitis B 'e' antigen (HBeAg) positive adults who are in the immune tolerant phase.. To evaluate 'off treatment' safety and sustained responses after treatment with entecavir and peginterferon alfa-2a in the treatment of chronic hepatitis B in HBeAg positive adults who are in the immune tolerant phase.. A single arm treatment study of 8 weeks of entecavir followed by 40 weeks of both entecavir and peginterferon alfa-2a in adults with HBeAg-positive chronic hepatitis B with normal or near normal ALT levels and high serum levels of HBV DNA ('immune tolerant' HBeAg-positive chronic hepatitis B). All participants will be followed until week 96 (48 weeks after discontinuation of therapy in the treatment group) at which time the primary outcome will be measured. ...

TABLE-US-00002 TABLE 2 Example Monomer 1 Monomer 2 Ratio 45 t-butyl methacrylate methacrylic acid 98/2 46 t-butyl methacrylate methacrylic acid 96/4 47 t-butyl methacrylate methacrylic acid 94/6 48 t-butyl methacrylate acrylic acid 98/2 49 t-butyl methacrylate acrylic acid 96/4 50 t-butyl methacrylate acrylic acid 94/6 51 t-butyl acrylate acrylic acid 98/2 52 t-butyl acrylate acrylic acid 96/4 53 t-butyl acrylate acrylic acid 94/6 54 t-butyl acrylate methacrylic acid 98/2 55 t-butyl acrylate methacrylic acid 96/4 56 t-butyl acrylate methacrylic acid 94/6 57 ethylcyclopentyl methacrylic acid 98/2 methacrylate 58 ethylcyclopentyl methacrylic acid 96/4 methacrylate 59 ethylcyclopentyl methacrylic acid 94/6 methacrylate 60 ethylcyclopentyl acrylic acid 98/2 acrylate 61 ethylcyclopentyl acrylic acid 96/4 acrylate 62 ethylcyclopentyl acrylic acid 94/6 acrylate 63 ethylcyclopentyl methacrylic acid 98/2 acrylate 64 ethylcyclopentyl methacrylic acid 96/4 acrylate 65 ethylcyclopentyl methacrylic acid 94/6 ...

This study was designed to assess the effects of blood-free reperfusion with oxygenated or unoxygenated intracoronary perfluorochemical (Fluosol-DA 20%) on myocardial perfusion and to determine its mechanism or mechanisms of limiting no reflow. Twenty-four dogs underwent 90 min of coronary occlusion followed by 210 min of reperfusion and were randomized to either: 1) blood-free reperfusion with intracoronary oxygenated perfluorochemical (20 ml/kg per min) for 20 min followed by blood reperfusion (n = 8); 2) intracoronary unoxygenated perfluorochemical administered as in those treated with oxygenated perfluorochemical (n = 8); and 3) blood reperfusion alone (control) (n = 8). Regional myocardial blood flow was serially determined and global myocardial perfusion was assessed by an intravenous injection of the fluorescent dye (thioflavin-S). Quantitative studies were performed to determine neutrophil infiltration and extent of endothelial injury.. Hemodynamic variables were similar in all groups. ...

Vol 9: Performance-Enhancing Methods for Au Film over Nanosphere Surface-Enhanced Raman Scattering Substrate and Melamine Detection Application.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Global Ethylene Glycol Butyl Ether Market Professional Survey Report 2018 1 Industry Overview of Ethylene Glycol Butyl Ether 1.1 Definition and Specifications of Ethylene Glycol Butyl Ether 1.1.1 Definition of Ethylene Glycol Butyl Ether 1.1.2 Specifications of Ethylene Glycol Butyl Ether 1.2 Classification of Ethylene Glycol Butyl Ether 1.2.1 Industrial Grade 1.2.2 Excellent Grade 1.3 Applications of Ethylene Glycol Butyl Ether 1.3.1 Coating 1.3.2 Ink 1.3.3 Solvent 1.3.4 Other 1.4 Market Segment by Regions 1.4.1 North America 1.4.2 Europe 1.4.3 China 1.4.4 Japan 1.4.5 Southeast Asia 1.4.6 India 2 Manufacturing Cost Structure Analysis of Ethylene Glycol Butyl Ether 2.1 Raw Material and Suppliers 2.2 Manufacturing Cost Structure Analysis of Ethylene Glycol Butyl Ether 2.3 Manufacturing Process Analysis of Ethylene Glycol Butyl Ether 2.4 Industry Chain Structure of Ethylene Glycol Butyl Ether 3 Technical Data and Manufacturing Plants Analysis of Ethylene Glycol Butyl Ether 3.1 Capacity and ...

Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthesized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by fluorescamine method and NMR analysis of their Boc-Phe-OH and Fmoc-Phe-OH conjugates. Pluronic and Pluronic-amine stabilized PLGA NPs prepared by nanoprecipitation were characterized by dynamic light scattering and zeta potential measurements. All of the systems showed high colloidal stability checked by electrolyte induced aggregation, although the presence of Pluronic-amine on the surface decreased the zeta potential in some extent. The introduction of reactive primary amine groups into the surface layer of PLGA NPs while preserving the ...

Purchase Report at: http://www.absolutereports.com/purchase/10410437. The Report Provides Insights on Major Ethylene Oxide and Ethylene Glycol Sales Market Points such as:. • Applications of Ethylene Oxide and Ethylene Glycol Sales Market. • Manufacturing Cost Structure Analysis of Ethylene Oxide and Ethylene Glycol Sales Market. • Raw Materials Sources Analysis of Ethylene Oxide and Ethylene Glycol Sales Market. • Price, Cost, Gross and Gross Margin Analysis of Ethylene Oxide and Ethylene Glycol Sales Market. • Supply, Consumption and Gap of Ethylene Oxide and Ethylene Glycol Sales Market 2016-2021. • New Project SWOT Analysis of Ethylene Oxide and Ethylene Glycol Sales Market. Inquiry for Buying Report at: http://www.absolutereports.com/enquiry/pre-order-enquiry/10410437 Analysis of Price, Cost, Gross Margin for Major Regions:. This particular section of the Ethylene Oxide and Ethylene Glycol Sales market report includes analysis of gross margin, cost and price. The Ethylene Oxide ...

TY - JOUR. T1 - Phosphoric acid doped imidazolium polysulfone membranes for high temperature proton exchange membrane fuel cells. AU - Yang,Jingshuai. AU - Li,Qingfeng. AU - Jensen,Jens Oluf. AU - Pan,Chao. AU - Cleemann,Lars Nilausen. AU - Bjerrum,Niels J.. AU - He,Ronghuan. PY - 2012. Y1 - 2012. N2 - A novel acid-base polymer membrane is prepared by doping of imidazolium polysulfone with phosphoric acid for high temperature proton exchange membrane fuel cells. Polysulfone is first chloromethylated, followed by functionalization of the chloromethylated polysulfone with alkyl imidazoles i.e. methyl (MePSU), ethyl (EtPSU) and butyl (BuPSU) imidazoliums, as revealed by 1H NMR spectra. The imidazolium polysulfone membranes are then doped with phosphoric acid and used as a proton exchange membrane electrolyte in fuel cells. An acid doping level of about 10-11mol H3PO4 per mole of the imidazolium group is achieved in 85wt% H3PO4 at room temperature. The membranes exhibit a proton conductivity of ...

This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety evaluation of the acrylic acid, sodium salt, co-polymer with acrylic acid, methyl ester, methacrylic acid, 2 hydroxypropylester, and acrylic acid cross-linked (CAS No. 117675-55-5, FCM Substance No 1022), to be used as liquid absorber in the form of fibres in absorbent pads for the packaging of fresh or frozen meat, poultry, and fish as well as fresh fruits and vegetables. The Panel considered that migration is not expected when the absorption capacity of the pads is not exceeded. Therefore no exposure from the consumption of the packed food is expected. The Panel also considered that none of these starting substances and the cross-linked polymer gives rise to concern for genotoxicity. Therefore the CEF Panel concluded that the use of the substance acrylic acid, sodium salt, co-polymer with acrylic acid, methyl ester, methacrylic acid, 2 hydroxypropylester, and ...

Polystyrene (PS)/multi-wall carbon nanotube (MWCNT) nanocomposites were prepared by melt mixing and by coagulation of PS/MWCNT sonicated dispersion. Before mixing and coagulation particles of MWCNT were covered with PS nanospheres by microemulsion polymerization to increase their dispersibility and compatibility with the matrix. Microemulsion polymerization was carried out under sonication in the presence of surfactants and a cross-linking agent. The structure of modified MWCNT filler was revealed by SEM and TEM microscopy analyses. They show that PS is well grafted onto surface of MWCNT in form of ca 30 nm nanospheres or as ca 3-8 nm PS film layer. Significant changes in properties were recorded mainly for the coagulated sample. Although no shift of T-g was recorded for the melt mixed composite, the coagulated sample shows an increase by 9 degrees C. Also the reinforcing effect of MWCNT was more pronounced for the same method of preparation (further supported by the filler modification). The ...

We report our theoretical investigation onto the shape dependence of two-photon absorption (TPA) in semiconductor nanocrystals (NCs). Based on a four-band model under effective mass approximation, we have developed a simple analytical theory capable of providing a quantitative explanation of the recent TPA measurement on CdS nanorods [Appl. Phys. Lett. 94, 103117 (2009)]. With this theory, we have systematically revealed the characteristics of TPA in CdSe and ZnO NCs with four different shapes: sphere, cube, cylinder and cuboid. Due to the splitting of degenerate energy levels caused by the decreased degree of symmetry, nanocuboids and nanocubes exhibit greater TPA cross-sections than nanocylinders and nanospheres of similar sizes, respectively. Similarly, nanocuboids and nanocylinders possess larger TPA cross-sections than nanocubes and nanospheres of similar lateral dimension, respectively. Given TPA-allowed transitions, nanocuboids show stronger size dependence than nanocylinders. The size ...

This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-polymer interaction studies were performed using {DSC} and FT-IR. The gelation temperature (Tsol-gel), gelation time, rheological behaviour, mucoadhesive characteristics of these gels, transcorneal permeation and ocular irritation as well as toxicity was investigated. {DSC} and FT-IR studies revealed that there may be electrostatic interactions between the drug and the polymers used. {P188} modified the Tsol/gel of {P407} bringing it close to eye temperature (35°C) compared with the formulation containing {P407} alone. Moreover, gels that comprised {P407} and {P188} exhibited a pseudoplastic behaviour at different concentrations. Furthermore, mucoadhesion study using mucin discs showed that in situ gel formulations have good mucoadhesive ...

A strategy to enhance drug effectiveness while minimizing controversial effects consists in exploiting host-guest interactions. Moreover, these phenomena can induce the self-assembly of physical hydrogels as effective tools to treat various pathologies (e.g., chronic wounds or cancer). Here, two Poloxamers®/Pluronics® (P407/F127 and P188/F68) were utilized to synthesize various LEGO-like poly(ether urethane)s (PEUs) to develop a library of tunable and injectable supramolecular hydrogels for drug delivery. Three PEUs were synthesized by chain extending Poloxamer/Pluronic with 1,6-cyclohexanedimethanol or N-Boc serinol. Other two amino-functionalized and highly responsive polymers were obtained thorough Boc-group cleavage. For hydrogel design, the spontaneous self-assembly of the poly(ethylene oxide) domains of PEUs with α-cyclodextrins was exploited to form poly(pseudo)rotaxanes (PPRs). PPR-derived channel-like crystals were characterized by X-Ray powder diffraction, Infra-Red and Proton ...

Nitric oxide (NO) is involved in physiological processes, including vasodilatation, wound healing and antibacterial activities. As NO is a free radical, designing drugs to generate therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor S-nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL) - chitosan (CS) hydrogel, with an easy and economically feasible methodology. CS is a polysaccharide with known antimicrobial properties. Scanning electron microscopy, rheology and differential scanning calorimetry techniques were used for hydrogel characterization. The results demonstrated that the hydrogel has a smooth surface, thermoresponsive behavior and good mechanical stability. The kinetics of NO release and GSNO diffusion from GSNO-containing PL/CS hydrogel demonstrated a sustained NO/GSNO release, in concentrations suitable for biomedical applications. The GSNO-PL/CS hydrogel demonstrated a concentration-dependent

triethylene glycol monomethyl ether chemical properties, What are the chemical properties of triethylene glycol monomethyl ether 112-35-6, What are the physical properties of triethylene glycol monomethyl ether ect.

Published: Nov 11, 2014 8:02 a.m. ET. - High Cure Rates in Nearly 800 HCV Patients with Advanced Liver Disease - BOSTON, Nov 11, 2014 (BUSINESS WIRE) -- Gilead Sciences, Inc. GILD, +0.55% today announced results from several Phase 2 and Phase 3 studies evaluating investigational uses of Harvoni® (ledipasvir 90 mg/sofosbuvir 400 mg) for the treatment of chronic hepatitis C virus (HCV) infection in patients with limited or no treatment options, including patients with decompensated cirrhosis, patients with HCV recurrence following a liver transplant and patients who failed previous treatment with other direct acting antivirals. These data will be presented this week at the 65th Annual Meeting of the American Association for the Study of Liver Diseases (The Liver Meeting2014) in Boston. "Chronic hepatitis C patients with advanced liver disease are among the most difficult to cure and traditionally have had limited or no treatment options," said Norbert Bischofberger, PhD, Executive Vice President ...

TY - JOUR. T1 - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery. AU - Park, Kyonghee. AU - Jung, Goo Young. AU - Kim, Myong Ki. AU - Park, Mork Soon. AU - Shin, Yong Kook. AU - Hwang, Jae Kwan. AU - Yuk, Soon Hong. PY - 2012/8. Y1 - 2012/8. N2 - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the ...

TY - PAT. T1 - Drug carriers comprising amphiphilic block copolymers. AU - Lewis, Andrew. AU - Armes, S.P.. AU - Lloyd, Andrew. AU - Salvage, Jonathan. PY - 2005/10/6. Y1 - 2005/10/6. N2 - An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug, for instance having a calculated or experimentally determined logP of at least 1.0, where P is the octanol:water partition coefficient. The hydrophilic block is preferably formed from acrylic monomer including phosphoryicholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups ...

Novel temperature- and pH-responsive ABA-type triblock copolymers, P(DEAEMA-co-MEO2MA-co-OEGMA)-b-PEG-b-P(DEAEMA-co-MEO2MA-co-OEGMA), composed of a poly(ethylene glycol) (PEG) middle block and temperature- and pH-sensitive outer blocks, were synthesized by atom transfer radical polymerization (ATRP). The composition and structure of the copolymer were characterized by 1H NMR and gel permeation chromatography (GPC). The temperature- and pH-sensitivity, micellization, and the sol-gel transitions of the triblock copolymers in aqueous solutions were studied using transmittance measurements, surface tension, viscosity, fluorescence probe technique, dynamic light scattering (DLS), zeta-potential measurements, and transmission electron microscopy (TEM). The lower critical solution temperature (LCST) of the triblock copolymer, which contains a small amount of a weak base group, (N,N-diethylamino) ethyl methacrylate (DEAEMA), can be tuned precisely and reversibly by changing the solution pH. When the copolymer

Due to the introduction of drug-eluting stents (DESs) and to improvements in therapy for both percutaneous coronary intervention (PCI) and coronary artery bypass surgery (CABG) patients, PCI is challenging CABG as the gold standard for treatment of three vessel (3VD) and left main (LM) coronary disease.. SYNTAX is a novel, randomized trial with nested registries comparing PCI with paclitaxel-eluting TAXUS stents to CABG for 3VD and LM patients to evaluate the best treatment for these patients with complex coronary disease.. Patients at participating centers will be evaluated by both a cardiothoracic surgeon and by an interventional cardiologist.. Those patients who are determined to be eligible for treatment by both PCI and CABG will be randomized to receive either PCI with a polymer-based paclitaxel-eluting TAXUS stent or CABG.. Patients who are determined to be unsuitable for treatment by PCI will be treated by CABG and will be entered into a CABG registry to help define the patient population ...

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TY - JOUR. T1 - Measurement of blood coagulation with considering RBC aggregation through a microchip-based light transmission aggregometer. AU - Lim, Hyunjung. AU - Nam, Jeonghun. AU - Xue, Shubin. AU - Shin, Sehyun. PY - 2011. Y1 - 2011. N2 - Even though blood coagulation can be tested by various methods and techniques, the effect of RBC aggregation on blood coagulation is not fully understood. The present study monitored clot formation in a microchip-based light transmission aggregometer. Citrated blood samples with and without the addition of calcium ion solution were initially disaggregated by rotating a stirrer in the microchip. After abrupt stop of the rotating stirrer, the transmitted light intensity over time was recorded. The syllectogram (light intensity vs. time graph) manifested a rapid increase that is associated with RBC aggregation followed by a decrease that is associated with blood coagulation. The time to reach the peak point was used as a new index of coagulation time (CT) ...

bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, bisphenol S diglycidyl ether, brominated bisphenol A diglycidyl ether, brominated bisphenol F diglycidyl ether, brominated bisphenol S diglycidyl ether, hydrogenated bisphenol A diglycidyl ether, hydrogenated bisphenol F diglycidyl ether, hydrogenated bisphenol S diglycidyl ether, 1,4-butanediol diglycidyl ether, 1,6-hexanediol diglycidyl ether, glycerol triglycidyl ether, trimethylolpropane triglycidyl ether, polyethylene glycol diglycidyl ether, polypropylene glycol diglycidyl ethers; polydiglycidyl ethers of polyether polyol obtained by adding one or more alkylene oxides to an aliphatic polyhydric alcohol such as ethylene glycol, propylene glycol, and glycerol; diglycidyl esters of an aliphatic long-chain dibasic acid; mono-diglycidyl ethers of aliphatic higher alcohol; phenol, cresol, butyl phenol, or mono-glycidyl ethers of polyether alcohol obtained by adding an alkylene oxide to these; glycidyl esters of a higher fatty ...

0040]In further detail, when adding the water-soluble dietary fatty acid gel formulation to water, the formulation should be added at a rate not to exceed 5 mL per second to a volume of water of 100 mL, or not more than 5 vol % of the water per second of the volume of water it is being added to. The rate of addition depends on the volume of water. Further, the water can be stirred continuously while the addition of the dietary fatty acid gel is being slowly added. The solution may be heated to increase solubility, if desired or necessary. That being said, the heating temperature is typically selected to avoid chemical breakdown of the dietary fatty acid and/or non-ionic surfactant. The temperature of the dietary fatty acid gel (dietary fatty acid/non-ionic surfactant) should not typically exceed 200° F., and the water temperature should also not typically exceed 200° F. Ideally, the temperature of both should be maintained at from 100 to 150° F., and in one embodiment, the water can ...

The research presented in this dissertation involves the synthesis, modification, characterization, and the application of polymeric surfactants in micellar electrokinetic chromatography (MEKC). Sodium undecenoyl-L-Leucinate (L-SUL) was synthesized and modified by use of alkali metal counterions, alcohols, and Triton X-102. Characterization of the modified poly-L-SUL was performed in order to elucidate the structural changes on the surfactants by use of four techniques. While surface tensiometry was used for the determination of the critical micelle concentration (cmc), fluorescence measurements were used for the determination of the polarity of the modified polymeric surfactants. The information about the size of the polymeric surfactants was obtained by use of pulsed field gradient-NMR (PFG-NMR). A superior chromatographic performance in MEKC was demonstrated by the modified polymeric surfactants as compared to the non-modified polymeric surfactants. A correlation between the polarity and the ...

Amersham Typhoon biomolecular imagers are GE's next generation of Typhoon FLA laser scanners. Amersham Typhoon imaging systems offer resolution as low as 10µm, detection limit as low as 3 pg, and linear dynamic range with greater than 5 orders of magnitude. Labeled proteins and nucleic acids can be precisely quantitated in gels, blots, microplates, culture dishes, and tissue sections. Amersham Typhoon IP (phosphor imaging) is dedicated to filmless autoradiography. Typhoon RGB has IP capability and adds visible fluorescence imaging and densitometry. Our most versatile model, Typhoon 5, adds two near-infrared (NIR) lasers to the functionalities in the RGB system. Amersham Typhoon NIR Plus and NIR are the models focused on fluorescent Weestern applications. Typhoon NIR Plus has 2 NIR lasers and a green laser to provide options for normalization. Typhoon NIR has 2 NIR lasers for standard NIR applications. ...

Polysorbate 80 is used as an emulsifier in foods. Order Now >> The study showed this emulsifier, one used in the Atlanta mice studies, promoted the movement of E coli bacteria across relevant cells. Also known as Polysorbate 80, E433 is a Polysorbate of Oleic Acid, used in foods as a stabilizer and emulsifier. It has no animal content. It is manufactured from glycerine (E422), which can be obtained from either animal fats or soy bean oil. Vegan Protein Bar from Misfits Health - Buy 12 for £18 - Triple-layered chocolate-coated bar, low sugar, gluten free, high in fibre. When choosing an emulsifier you should start with asking what your continuous phase is and which are the particles floating in that phase. The Vegan Society, which discourages … I like sunflower seed lecithin, since I try to avoid soy. Semi-synthetic emulsifier . For a vegan ice cream, lecithin can take the place of egg yolk. But for many people with food allergies and intolerances, … Food emulsifiers act as an interface ...

Page contains details about carbon nanotubes/poly(propylene oxide)-poly(ethylene glycol)-poly(propylene oxide)/titania oligomers . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

TY - CONF. T1 - Photocontrol of zeta-potential of poly(styrene) particles prepared by soap-free emulsion copolymerization. AU - Kishimoto, Hiroaki. AU - Iyoda, Tomokazu. AU - Nakagawa, Masaru. AU - Watanabe, Masaru. AU - Naga, Katsutoshi. PY - 2005/12/1. Y1 - 2005/12/1. N2 - We previously reported the photo-oxidation method for preparing charge-photocontrolled cationic poly(styrene) particles in water. When the aqueous dispersion was irradiated with UV light, the zeta-potential was shifted negatively due to photo-oxidation and the average diameter was maintained. In this study, we report that the photocontrol method of zeta potential was applicable to several types of poly(styrene) particles, such as cationic, zwitterionic and anionic microspheres. The poly(styrene) particles were prepared by soap-free emulsion copolymerization. The changes of zeta potential and average diameter by UV light exposure were investigated using the three-kind of poly(styrene) microspheres.. AB - We previously ...