Free Online Library: Potential Anticancer Mechanisms of a Novel EGFR/DNA-Targeting Combi-Molecule (JDF12) against DU145 Prostate Cancer Cells: An iTRAQ-Based Proteomic Analysis.(Research Article, epidermal growth factor receptor , Report) by BioMed Research International; Biotechnology industry High technology industry Apoptosis Care and treatment Cancer treatment Cellular signal transduction Epidermal growth factor receptors Gene expression Prostate cancer Drug therapy Genetic aspects Protein-protein interactions Proteins
Carter, S K. and Friedman, M A., 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic, Dic, nsc- -45388)-a new antitumor agent with activity against malignant melanoma. (1972). Subject Strain Bibliography 1972. 568 ...
TY - JOUR. T1 - Clinical trials of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) given intravenously in the treatment of malignant melanoma in Uganda.. AU - Vogel, C. L.. AU - Comis, R.. AU - Ziegler, J. L.. AU - Kiryabwire, J. W.. PY - 1971/4/1. Y1 - 1971/4/1. UR - http://www.scopus.com/inward/record.url?scp=0015039859&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015039859&partnerID=8YFLogxK. M3 - Article. C2 - 5118684. AN - SCOPUS:0015039859. VL - 55. SP - 143. EP - 149. JO - Journal of the National Cancer Institute. JF - Journal of the National Cancer Institute. SN - 0027-8874. IS - 2. ER - ...
In this tutorial, well compare positive and negative condition for the count and total area of lipid droplets by adding the oleic acid or Triacsin C. | Yokogawa Electric Corporation
Alfa Aesar™ 2-Bromo-1-(cyanomethyl)imidazole-4,5-dicarbonitrile, 97% 250mg Alfa Aesar™ 2-Bromo-1-(cyanomethyl)imidazole-4,5-dicarbonitrile, 97%...
Triazene ligands are introduced, for the first time, in the precursor chemistry for their ability to afford oxygen-free molecular precursors of Fe0 nanoparticles. For this purpose, we synthesized new asymmetric triazene ligands t-BuN [[double bond, length as m-dash]] N-NHR (R = Et, i-Pr, n-Bu) featuring differe...
LB-299 Blockade of bcr-abl by the inhibitor imatinib (GleevecTM) has proven efficacious in the therapy of CML. However resistance to the drug emerges at the advanced phases of the disease. Therefore, novel therapy models remained to be designed. We have developed a novel approach based on the development of a dual targeted agent termed combi-molecule designed to not only block bcr-abl but also to damage DNA. ZRF1, the first optimized prototype of the approach was programmed to degrade into another inhibitor ZRF0 + a methyldiazonium species. It was an approximately 2-fold stronger abl tyrosine kinase (TK) inhibitor than GleevecTM and a more potent DNA damaging agent than Temodar®. In the p53 wild-type Mo7p210 cells ZRF1 was approximately 1000-fold superior to that of equieffective combinations of GleevecTM+Temodar®. More importantly, its superior potency over GleevecTM was more pronounced in bcr-abl+ cells co-expressing wild-type p53. Studies to rationalize these results showed that, through ...
A series of five new 1-(substituted phenyl)-2-phenyl-4-(substituted benzylidine)-imidazole-5-one derivatives (or) 5(4 H )-imidazolones have been synthes..
1-[(4-Nitrophenyl)methyl]imidazole-2-carbaldehyde | C11H9N3O3 | CID 62223319 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-(2-Methylpyridin-4-yl)imidazole-2-carbothioamide | C10H10N4S | CID 116170976 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule dihydro-1h-pyrrolo[1,2-a]imidazole-2,5(3h,6h)-dione (C6H8N2O2) from the PQR.
You are viewing an interactive 3D depiction of the molecule (2Z)-2-(2-amino-5H-thiazol-3-ium-5-id-4-yl)-N-[(1S)-1-[[[4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-1-ium-5-id-2-yl)-5-oxo-1,2,4-triazole-1,4-diium-1-yl]sulfonylcarbamoylamino]methyl]-2-oxo-ethyl]-2-(1-methylethoxyimino)acetamide; carbon dioxide (C23H30N10O13S2) from the PQR.
May cause respiratory irritation.. P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c. H315-H319-H335. TSCA : No. Recommended Storage : Ambient temperatures. ...
May cause respiratory irritation.. P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c. H315-H319-H335. TSCA : No. Recommended Storage : Ambient temperatures. ...
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Data Availability StatementThe writers declare that the main data supporting the findings of this study are available within the article. the embedded MSCs were analysed by co-staining with alkaline phosphatase (ALP) and oil red O. The expression of specific markers at the gene level was detected after a 3-day culture. Results Confocal microscopy indicated that all tested hydrogels supported MSC growth and viability during the culture period. Higher expression of adipogenic and osteogenic markers (ALP and lipoprotein lipase (LPL)) in stiffer 3D-bioprinted matrices demonstrated a more significant response of MSCs to stiffer hydrogels Triacsin C with respect to differentiation, which was more robust in differentiation-inducing medium. However, the LPL expression in stiffer 3D-bioprinted constructs was reduced at day 3 regardless of the presence of differentiation-inducing factors. Although MSCs embedded in softer hydrogels to some extent proceeded toward adipogenic and osteogenic lineages within a ...
ACSL1, CT (ACSL1, FACL1, FACL2, LACS, LACS1, LACS2, Long-chain-fatty-acid-CoA ligase 1, Acyl-CoA synthetase 1, Long-chain acyl-CoA synthetase 1, Long-chain acyl-CoA synthetase 2, Long-chain fatty acid-CoA ligase 2, Palmitoyl-CoA ligase 1, Palmitoyl-CoA ligase 2 ...
Buy our Recombinant Human FACL4 protein. Ab152375 is a full length protein produced in Wheat germ and has been validated in WB, ELISA, SDS-PAGE. Abcam provides…
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Bioelektrody Lifewave® są nowoczesną formą fototerapii. Zawierają kryształy organiczne, które pod wpływem ciepła wytwarzanego przez ciało odbijają niewielkie ilości światła w zakresie pasm podczerwieni i światła widzialnego.
ACSL3兔多克隆抗体(ab78229)可与人样本反应并经WB, ELISA, IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Consciousness is regained in 5-15 min due to the concept of redistribution of the drug into highly perfused organs first and then to the low perfused organs like fat and muscles ...
Fine Art Conservation Laboratories (FACL, Inc.)Historic Murals Removed, Restored, Reinstalled - Minerva Teicherthttp://www.fineartconservationlab.com Fine art conservation, painting conservation, art restoration Fri, 27 Mar 2015 19:05:08 +0000 http://backend.userland.com/rss092 en
Development of an in vitro Model System for Assessing the Effect of the Adrenoleukodstrophy Protein on Very Long-Chain acyl-CoA Synthetase Activity ...
摘要. Unlocking the endosome allows the release of siRNAs into the cytoplasm following the cellular uptake of nanoparticles made up of siRNAs and polyspermine imidazole-4,5-imine. In their Communication on page 7938 ff., T. Jin and co-workers show that a polymer of spermine with a pH-sensitive linkage degrades, upon entry into the endosome, into spermine and a nontoxic metabolite. Assays in cells and mice showed effective gene silencing by the polymer-packaged siRNAs without cytotoxicity.. ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Founded in 2011, Suzhou Xinkai Bio-Medical Technology Co., Ltd. is located in Suzhou New District of Suzhou city in Jiangsu province. Xinkai focus is on the development of...
Eventually I found something neat in TSM on the third day, it is the TSM for VE (Virtual Environment). Unit 7: Customizing the Tivoli Storage Manager database and recovery log Lesson 1: Database and recovery log functions and considerations Database and recovery log - Server uses database to manage information about client files- Recovery log…
TY - JOUR. T1 - Human fatty acid transport protein 2a/very long chain Acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. AU - Melton, Elaina M.. AU - Cerny, Ronald L.. AU - Watkins, Paul A.. AU - DiRusso, Concetta C.. AU - Black, Paul N.. PY - 2011/9/2. Y1 - 2011/9/2. N2 - The trafficking of fatty acids across the membrane and into downstream metabolic pathways requires their activation to CoA thioesters. Members of the fatty acid transport protein/ very long chain acyl-CoA synthetase (FATP/Acsvl) family are emerging as key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.We have expressed two naturally occurring splice variants of human FATP2 (Acsvl1) in yeast and 293T-REx cells and addressed their roles in fatty acid transport, activation, and intracellular trafficking. Although both forms (FATP2a (M r 70,000) and FATP2b (M r 65,000 and lacking ...
Desaturation of fatty acids is a key reaction in the biosynthesis of moth sex pheromones. The main component of Spodoptera littoralis sex pheromone blend is produced by the action of delta11 and delta9 desaturases. In this article, we report on the cloning of four desaturase-like genes in this species: one from the fat body (Sls-FL1) and three (Sls-FL2, Sls-FL3 and Sls-FL4) from the pheromone gland. By means of a computational/phylogenetic method, as well as functional assays, the desaturase gene products have been characterized. The fat body gene expressed a delta9 desaturase that produced (Z)-9-hexadecenoic and (Z)-9-octadecenoic acids in a (1:4.5) ratio, whereas the pheromone gland Sls-FL2 expressed a delta9 desaturase that produced (Z)-9-hexadecenoic and (Z)-9-octadecenoic acids in a (1.5:1) ratio. Although both delta9 desaturases produced (Z)-9-tetradecenoic acid from myristic acid, transformed yeast grown in the presence of a mixture of myristic and (E)-11-tetradecenoic acids produced ...
article{e2555049-379e-4f7e-a5f5-ab24669053a4, abstract = {,p,Two heliozelid species, ,i,Antispila oinophylla,/i, van Nieukerken & Wagner and ,i,Holocacista rivillei,/i, (Stainton) severely infest Italian grapevines. The volatile pheromones from calling females were collected by solid phase micro extraction (SPME) and analyzed by gas chromatography with electroantennographic detection (GC-EAD). Two compounds from ,i,A. oinophylla,/i, females eliciting electrophysiological activity from the conspecific male antenna were identified as (Z)-5-tetradecenal and (Z)-7-tetradecenal by coupled gas chromatography/mass spectrometry (GC/MS) analysis. SPME collections from ,i,H. rivillei,/i, produced no GC-EAD active compounds but analysis of fatty acyl moieties in the pheromone gland, demonstrated the presence of the putative pheromone biosynthetic precursors (Z)-5-dodecenoic acid and (Z)-7-tetradecenoic acid. Field trapping experiments in Italy confirmed that (Z)-5-tetradecenal and (Z)-7-tetradecenal ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Novel imidazole-5-acetic acid derivatives of the formula: ##STR1## wherein R1 is lower alkyl, cycloalkyl or, phenyl which may be substituted with one to three of halogen, nitro, amino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl; X1, X2 and X3 are each hydrogen, halogen, nitro, amino, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl; Y is halogen and R2 is hydrogen or lower alkyl; provided that X1 is halogen, lower alkyl, lower alkoxyl, benzyloxyl or hydroxyl when R1 is unsubstituted or substituted phenyl only with one halogen, di(lower alkyl)amino, lower alkyl or lower alkoxyl, and its salts have hypotensive activity.
CAS Number:24155-42-8 Name:1H-Imidazole-1-ethanol,a-(2,4-dichlorophenyl)- Superlist Name:alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Formula:C11H10Cl2N2O Molecular Weight:257.12 Synonyms:Imidazole-1-ethanol,a-(2,4-dichlorophenyl)-...
In: Rees, Philip; Mackay, Louise; Martin, David and Durham, Helen eds. Hollway, Wendy and Jefferson, Tony (2009). Articulating British classicism: New approaches in Eighteenth Century architecture. In: DeSouza, Ruth and Williamson, Andy eds. Source London, UK: Palgrave Macmillan. Journal of Information Technology, 24(1) pp. 126-138. Generalized Schemata Theorem Incorporating Twin Removal for Protein Structure Prediction. J; Hakala, Pasi and Baskill, Darren (2008). http://www.avermedia.com/gaming/product/game_capture/live_gamer_hd Pattern Recognition, 41(10) pp. 3153-3165. Planetary Landers and Entry Probes. Molecular Pharmacology, 73(5) pp. 1424-1433. Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: Synthesis and stability of N-acylamino acid derivatives of triazenes. Biological processes associated with impact events. WASP-7: A bright transiting-exoplanet system in the Southern Hemisphere. A.; Maxted, P. Open and Flexible Learning Series. Journal of Volcanology and ...
Expression of ACSL1 (ACS1, FACL1, FACL2, LACS, LACS1, LACS2) in thyroid gland tissue. Antibody staining with HPA011316 and HPA011964 in immunohistochemistry.
Acsm2 (untagged) - Mouse acyl-CoA synthetase medium-chain family member 2 (Acsm2), nuclear gene encoding mitochondrial protein, transcript variant 3, (10ug), 10 µg.
Acyl-CoA synthetase medium-chain family member 2B (ACSM2B), nuclear gene encoding mitochondrial protein, transcript variant 1, 20 µg.
5-HETE stimulated PC3 cells to phosphorylate ERK1/2 and Akt, as detected in Western blots probed with phospho-specific antibodies (Fig. 2) ⇓ . Because blots probed with antibody to total (i.e., phosphorylated plus unphosphorylated species) ERK1/2 or Akt had no such change (data not shown), and because phosphorylation at the antibody-defined sites raises the activity of these kinases, Fig. 2 ⇓ data imply that 5-HETE induces ERK and Akt activation. ERK and Akt phosphorylation responses developed within 1 min, peaked at 5-10 min, and tended to persist for ≥60 min (ERK) or returned to baseline by 40 min (Akt). 5-HETE was more potent than 5-oxoETE, whereas 5-oxo-15-OH-ETE, 15(S)-hydroxy-6,8,11,13-Z,Z,Z,E-ETE, 8(S),12(S)-dihydroxy-5,9,11,13-Z,E,Z,E-ETE, and LTB4 were inactive (Fig. 2) ⇓ . 5-HETE, 5-oxoETE, and 5-oxo-15-OH-ETE likewise stimulated PMNs to activate ERKs; responses began by 1 min, peaked at 5-10 min, and declined thereafter. However, PMNs showed 5-fold rises in ERK phosphorylation ...
Deta is a leading supplier of electrical products. All of our products are designed to a high specification and are tested to their relevant British Standard, allowing them to carry the CE mark where required. Manufacturing is carried out in a strict quality controlled environment, where all of our products are tested during production to ensure they meet the exact requirements to enable them to be guaranteed for up to 25 years.
1-(5-phospho-beta-D-ribosyl)-5-AMP + H2O =, 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide Last modified: 2019-05-24. Chemically balanced: yes. ...
The news sets Bjergsen up to remain with TSM for the rest of his esports career as he re-signs with the org. Lets look at how this changes the future.
P. R. Morris, R. E. Hook, and G. W. Whelan, A New Composite-Sample Method for Orientation-Distribution Analysis, Textures and Microstructures, vol. 19, no. 1-2, pp. 1-8, 1992. doi:10.1155/TSM.19.1. ...
TY - JOUR. T1 - Nitric oxide stimulates interleukin-6 production in skeletal myotubes. AU - Makris, Anastasia C.. AU - Sotzios, Yannis. AU - Zhou, Zongmin. AU - Makropoulou, Maria. AU - Papapetropoulos, Nektarios. AU - Zacharatos, Panagiotis. AU - Pyriochou, Anastasia. AU - Roussos, Charis. AU - Papapetropoulos, Andreas. AU - Vassilakopoulos, Theodoros. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Strenuous exercise leads to the up-regulation of interleukin-6 (IL-6) production and enhanced nitric oxide (NO) release within the contracting skeletal muscles. In this study, we investigated whether NO regulates IL-6 production in C2C12 myotubes. These cells exhibited a concentration-dependent increase in IL-6 production upon stimulation with NO donors (Z)-1-[N-(2- aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate), (Z)-1-[N-(3-aminopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate (PAPA-NONOate), and sodium nitroprusside (SNP). This treatment did not alter cGMP levels nor did the ...
Expression of ACSL1 (ACS1, FACL1, FACL2, LACS, LACS1, LACS2) in urinary bladder tissue. Antibody staining with HPA011316 and HPA011964 in immunohistochemistry.
2-Piperidin-1-ium-1-ylethyl N-(2-decoxyphenyl)carbamate chloride/ACM55792295 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Cleverly weaving proven technology with a vintage aesthetic, X-T30 II has much to offer stills photographers and videographers of all levels. The 26.1MP back-illuminated X-Trans sensor and X-Processor 4 imaging engine combine to deliver exceptional performance, with autofocusing down to -7EV in just 0.02 secs -and deta
cGKI兔多克隆抗体(ab69532)可与小鼠, 大鼠, 人, 猪样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Vineri 30 iulie 2010. ORA 1100 - Simpozion 650 de ani de atestare documentara a orasului Deta. 1600 - DESCHIDEREA SERBARILOR ZILELOR ORASULUI DETA. - Fanfara din Costeiu (Serbia). 1615 - Ansamblul BUJORUL Timisoara. 1630 - Ansamblul de dansuri Deta. 1640 - Codruta Moldovan. 1710 - Ansamblul de dansuri sârbesti Sfantul George Recas 1720 - Roxana Mircea. 1750 - Ansamblul de dansuri bulgaresti Deta. 1800 - Ramona Mercescu. 1830 - Ansamblul de dansuri Recasana din Recas. 1850 - Ion Luca Jurjescu. 1920 - Ansamblul de dansuri Deta -dansuri tiganesti. 1930 - Maria Tirean. 2000 - Ansamblul de dansuri populare germane Cavaleria Traditiilor Becicherecul Mic. 2020 - Titian Puichita. 2050 - Ansamblul de dansuri maghiare Deta. 2110 - Luminita Jucu Pascu 2140 - Ansamblul BUJORUL Timisoara. 2200 - Tinu Veresezan si formatia sa.. Sambata 31 iulie 2010. ORA 1500 - Ansamblul folcloric din Izbistea (Serbia). 1600 - FLAT - muzicã retro. 1800 - Program prezentat de Casa de cultura a comunei Bordany ...
diethylenetriamine 111-40-0 NMR spectrum, diethylenetriamine H-NMR spectral analysis, diethylenetriamine C-NMR spectral analysis ect.
TY - JOUR. T1 - Molecular Control of Self-Assembled Monolayer Films of Imidazole-2-thiones. T2 - Adsorption and Reactivity. AU - Arduengo, Anthony J.. AU - Moran, John R.. AU - Rodriguez-Parada, J.. AU - Ward, Michael D.. PY - 1990/3. Y1 - 1990/3. UR - http://www.scopus.com/inward/record.url?scp=0000388610&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0000388610&partnerID=8YFLogxK. U2 - 10.1021/ja00172a055. DO - 10.1021/ja00172a055. M3 - Article. AN - SCOPUS:0000388610. VL - 112. SP - 6153. EP - 6154. JO - Journal of the American Chemical Society. JF - Journal of the American Chemical Society. SN - 0002-7863. IS - 16. ER - ...
中文摘要本論文研究主要為利用室溫自組裝反應,設計出過渡金屬與具有生物鹼基性質的有機配子反應形成之金屬-有機配位聚合物。此系列反應的主要調控因子為溶劑之酸鹼值及助溶劑的選擇。使用的有機配子:4,6-dihydroxypyrimidine(dhp-H2)、2,4-dihydroxypyrimidine-5-carboxylic acid(H3L1)與2-methyl-1H-benzo[d] imidazole-5- carboxylic acid(H2L2)。將上述有機配子與鎳、鈷、鋅、鋱與銪等金屬離子以室溫自組裝方式共合成出八個金屬-有機配位聚合物,分別有單體、一維與三維等結構之產物。依據有機配子的不同共區分為三個部份,分別為第一部份:4,6-dihydroxypyrimidine(dhp-H2)分別與鈷、鎳、鋅金屬鹽類反應,合成出單體 [Ni(Hdhp)2(H2O)4](HF-1),[Co(Hdhp)2(H2O)4](HF-2)與三維聚合物[Co(dhp) (H2O)]n(HF-3) and [Zn(dhp) (H2O)]n(HF-4)、第二部份:2,4-dihydroxypyrimidine-5-carboxylic acid(H3L1)
1-(1-Methylpiperidin-1-ium-2-yl)propan-2-yl 9h-fluorene-9-carboxylatechloride/ACM67227229 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Synthesis How to make a great presentation in powerpoint novel sugar or azasugar analog anthra[1,2- d ] imidazole-6,dione derivatives and interesting evaluation.
The Targus 12-14 T-1211 Vertical Messenger (TSM69104 - Black) delivers everyday protection for your laptop in a lightweight yet durable package.
And a fraction of what was done in Texas. If she lived in Texas, shed have been in the ground for 14 years and 11 months already.