Despite increased emphasis on evidence based practice in recent years a gap remains between evidence and practice, particularly in resource poor countries. Few studies to date have examined the use of knowledge translation strategies to improve health care outcomes in low income countries. However, given that the majority of health care in these settings is provided by workers with less training and limited resources, the theoretical potential for knowledge translation strategies to improve health care delivery and outcomes by integrating best evidence into routine practice may be greatest in these settings.. Knowledge translation (KT) is an approach to changing health care provider behavior to reduce the gap between evidence and practice in health care delivery. There has been a tendency for knowledge translation interventions to employ generic, off the shelf, strategies, and apply them to deal with specific issues. This generic approach, fails to recognize the variability in the specific ...
Despite increased emphasis on evidence based practice in recent years a gap remains between evidence and practice, particularly in resource poor countries. Few studies to date have examined the use of knowledge translation strategies to improve health care outcomes in low income countries. However, given that the majority of health care in these settings is provided by workers with less training and limited resources, the theoretical potential for knowledge translation strategies to improve health care delivery and outcomes by integrating best evidence into routine practice may be greatest in these settings.. Knowledge translation (KT) is an approach to changing health care provider behavior to reduce the gap between evidence and practice in health care delivery. There has been a tendency for knowledge translation interventions to employ generic, off the shelf, strategies, and apply them to deal with specific issues. This generic approach, fails to recognize the variability in the specific ...
An intensive, week-long introduction to translational cancer research - including cancer medicine, the clinical cancer research environment and collaborative team science - for basic scientists who are predoctoral students and postdoctoral fellows, early-career scientists and senior scientists in transition to translational research. This workshop is hosted in close collaboration with the Dana-Farber Cancer Institute/Harvard Cancer Center, comprised of Beth Israel Deaconess Medical Center, Brigham and Womens Hospital, Childrens Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Harvard School of Public Health and Massachusetts General Hospital.. The Translational Cancer Research for Basic Scientists Workshop will provide basic research scientists with a better understanding of translational research, teach them how to adapt their research for maximum clinical impact and help them transition into a new career in translational cancer medicine. This innovative workshop ...
Translational Cancer Research publishes the results of novel research investigations including risk assessment, cellular and prevention, detection, diagnosis and treatment of human cancers.
The Translational Cancer Research for Basic Scientists Workshop will provide basic research scientists with a better understanding of translational research, teach them how to adapt their research for maximum clinical impact, and help them transition into a new career in translational cancer medicine. This innovative workshop addresses many aspects of translational research including leading multidisciplinary teams, working collaboratively and effectively with industry partners, recognizing the unique needs and environment of the clinic and clinical laboratories, dealing with the regulatory and compliance issues in translational science, and understanding the perspective of the patient in order to place research questions into a broader context. During the course of the week, attendees will gain perspective and background knowledge of the disease from translational scientists in academia and industry, clinicians, and patients, while learning about the latest methods and approaches in ...
Clinical and translational medicine plays a unique and critical role in fostering the flow of bidirectional information between basic and clinical scientists, optimizing new biotechnologies, improving clinical application of new therapeutic concepts, and ultimately improving the quality of life for patients. The term Clinical and Translational Medicine (CMT) is defined here as clinical potential and application of translational research and science to improve the understanding of mechanisms and therapies of human diseases, a new and important concept for the development of disease-specific biomarkers and therapeutic strategies to monitor and cure disease. Clinical and Translational Medicine as an international open-access journal publish articles focused on novel advances in clinical, translational, and clinically-relevant basic science, to accelerate the transition from preclinical research to clinical applications and the communication between basic and clinical scientists. Clinical and ...
Although treatment success rates were higher in both intervention arms than in the control and highest in the PALM PLUS and LHW intervention group, the differences did not reach statistical significance. While this may represent a true finding, a number of other factors may be responsible for our failure to detect a significant effect of the intervention.. First, the lack of a significant difference may be an artefact as our projected sample size was not attained due to the loss of four health centers and decreased TB case notification rate during the trial period. The resultant loss of statistical power may have reduced our ability to detect an effect of the intervention. Second, it is possible that the trials pragmatic design contributed to the lack of effectiveness where a more intensively supported program may have been more successful. However, a heavily supported program would not be feasible in the resource-constrained Malawi health care system. Third, it is possible that a significant ...
Centre for Translational Cancer Research news archive, read more news stories about cancer research by our researchers and colleagues at the University of Otago.
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; www.theTCR.org) is an Open Access, peer-reviewed journal, published by Pioneer Bioscience Publishing Company (PBPC), publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients.
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; www.theTCR.org) is an Open Access, peer-reviewed journal, published by Pioneer Bioscience Publishing Company (PBPC), publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients.
|p||i|Clinical and Translational Medicine|/i| plays an important and recognized role in reporting knowledge that contributes towards the understanding of molecular mechanisms of disease. |i|Clinical and Translational Medicine|/i| aims to foster a predictive, preventive, personalized and practical approach towards precision medicine, leading to improved patient prognosis. The journal provides a forum for exchange of ideas between basic and clinical scientists on molecular and cellular mechanisms of disease and potential therapies.|/p||p|The journal covers all areas of clinical and translational medicine but also has several special sections:|/p||ul||li|Clinical and translational cardiovascular medicine - Edited by Yong-Xiao Wang|/li||li|Clinical biostatistics - Edited by Christian Baumgartner and Xiangdong Wang|/li||li|Clinical genomics - Edited by Olaf A. Bodamer and Gilbert S. Omenn|/li||li|Stem cell therapies Edited by Mariusz Z. Ratajczak|/li||li|Translational respiratory medicine - Edited by Chunxue
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Basic and Translational Research on Decision Making in Aging and Alzheimers Disease (R01 - Clinical Trial Optional) PAR-18-544. NIA
Biomedical and translational research on sex-drug-gene interactions: what are the trends, gaps, and barriers? Does Canada have the capacity to be a leader in this space ...
Translational Research on the Mechanism of Water and Electrolyte Movements into the Cell Reviewer and Curator: Larry H. Bernstein, MD, FACP Introduction This article is the first in a three part curation covering work that has great importance to our understanding of hydration and possibly the effects of dehydration in cell physiology, and studied effects on…
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Roybal Centers for Translational Research on Aging (P30) RFA-AG-14-004. NIA
Implementation science is the study of methods to promote the adoption and integration of evidence-based practices, interventions and policies into routine health care and public health settings. Implementation research plays an important role in identifying barriers to, and enablers of, effective global health programming and policymaking, and leveraging that knowledge to develop evidence-based innovations in effective delivery approaches.. As outlined in the Centers Strategic Plan, Fogarty aims to support research and research training in implementation science using a distributed approach across its programs. Also, projects coordinated by the Center for Global Health Studies (CGHS) at Fogarty support implementation science research methods and frameworks, and use innovative approaches to supporting implementation science. These projects address a wide variety of critical global health research areas, such as HIV prevention, transmission and treatment; household air pollution; mobile health; ...
This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field ...
The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partner, UMass Memorial Health Care. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. The goals of the UMCCTS are to 1) To accelerate the translation of basic discoveries into practical, cost effective solutions that improve human health; and 2) To develop and support the next generation of leaders in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.
The Graduate Program in Molecular and Translational Medicine (GPMTM) at Boston University is an interdepartmental, interdisciplinary program based in the Department of Medicine. The mission of the Molecular and Translational Medicine Program is to provide state-of-the-art didactic and research training that produces PhD and MD/PhD scientists who will become leaders in the field of clinically based research.. The program strives to create research opportunities that take full advantage of the wealth of resources available through clinical reagents,clinical expertise, and diverse patient populations at the Boston University Medical Center. At completion of the program each student will have the training and understanding of biomedical systems required to successfully conduct integrative translational research.. ...
FOX CHASE CANCER CENTER has hired Attila Seyhan, PhD, for the newly created position of Director of Translational Medicine Operations. Dr. Seyhan will work closely with Wafik S. El-Deiry, MD, PhD, FACP, Deputy Cancer Center Director for Translational Research, to manage and promote multiple initiatives, including development of investigator-initiated clinical trials and other translational protocols, protocol writing and manuscript preparation, organization of translational medicine events, support for translational requests for application, and grant preparation and submissions. He also will work with industry to follow through on investigator-initiated basic and translational letters of intent and concepts. This work will involve collaboration with clinicians, scientists, regulatory personnel, administrators, tech transfer office staff, the grants management office, institutional review board, institutional advancement, and external entities. A trained molecular biologist, Dr. Seyhan has more ...
The capabilities being gathered into NCATS will offer researchers unparalleled opportunities for intense focus on the reengineering of the translational process, from initial target identification to first-in-human application of small molecules, biologics, diagnostics, and devices. Taking care to avoid a top-down management approach, NCATS will count on the scientific community to conceive highly innovative ideas and propose potential implementation projects. The most promising programs will be funded through NIHs highly respected, peer-reviewed grant- and contract-awarding process. Early discussions with a variety of stakeholders have identified several components of translational science that are ripe for the new scientific approach offered by NCATS and will likely be the subject of early targeted funding opportunities.. Therapeutic target validation. Translational science is awash with newly discovered but unvalidated therapeutic targets. NCATS will support broadly applicable rather than ...
Rotating students interested in the Program in Translational Medicine may find it helpful to know which laboratories on campus have hosted Translational Medicine Trainees in the past. The lists below show the basic science mentors and the clinical co-mentors of all current and past trainees.. ...
High Throughput Sequencing A Pilot Study By Sameek Roychowdhury Matthew K Iyer Dan R Robinson Robert J Lonigro Yi Mi Wu Xuhong Cao Shanker Kalyana Sundaram Lee Sam O Alejandro Balbin Michael J Quist Terrence Barrette Jessica Everett Javed Siddiqui Lakshmi P Kunju Nora Navone John C Araujo Patricia Troncoso Christopher J Logothetis Jeffrey W Innis David C Smith Christopher D Lao Scott Y Kim J Scott Roberts Stephen B Gruber Kenneth J Pienta Moshe Talpaz Arul M Chinnaiyan Science Translational Medicine 30 Nov 2011 111ra121 The mutations present in advanced cancers can be identified by integrative high throughput sequencing to enable biomarker driven clinical trials and ultimately treatment Editor s Summary Abstract Full Text PDF Editors Choice PPAR for the Course in Type 2 Diabetes By Diane Gesty Palmer Science Translational Medicine 30 Nov 2011 111ec192 Targeting adipocyte specific PPARγ may be a new strategy for treating type 2 diabetes Full Text Genetic Screening to Beat Cancer By Carrie M ...
In order to accomplish these objectives open discussion and cooperation among companies, academic, and other institutions will be increasingly important. For all of these reasons, we have created a new subsection of the Journal of Translational Medicine.. Why should a Subsection of the Journal of Translational Medicine be dedicated to combination strategies? Because we want to stimulate discussion over this hot topic. In recent years, several compounds have been developed to treat a broad number of diseases targeting a specific mechanism. However, vast majority of common diseases are multi-factorial and cannot realistically be controlled by targeting a single or few pathways.. Tuberculosis treatment is a classic example of combination therapy [1]. After the discovery of Streptomycin in 1944, improvement in the effectiveness of therapy was observed with the addition of Isoniazid, the first oral mycobactericidal drug in 1952 and Rifamycins in 1957. The introduction of Rifampicin in 1970 further ...
Summary of Translational Medicine - e-Series A: Cardiovascular Diseases, Volume Four - Part 1 Author and Curator: Larry H Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN Part 1 of Volume 4 in the e-series A: Cardiovascular Diseases and Translational Medicine, provides a foundation for grasping a rapidly developing surging scientific endeavor that…
Translational Medicine Communications is an interdisciplinary forum for all scientifically valid research from across translational medicine. We are committed ...
Annals of Translational Medicine&Epidemiology is an open access journal committed to publish articles in all areas of Translational Medicine&Epidemiology.
Fishpond Australia, Carotenoids and Vitamin A in Translational Medicine (Oxidative Stress and Disease) by Werner Siems (Edited ) Olaf Sommerburg (Edited ). Buy Books online: Carotenoids and Vitamin A in Translational Medicine (Oxidative Stress and Disease), 2013, ISBN 1439855269, Werner Siems (Edited by) Olaf Sommerburg (Edited by)
Mayo Clinic Center for Clinical and Translational Science (CCaTS):Graduates of the Ph.D. track in clinical and translational science.
We support translational studies and cross-disciplinary investigation in epidemiology, behavioral health, clinical trials, and public health. The Core will expand its longitudinal database from the existing clinical cohorts to include neuropsychiatric and neurocognitive assessment of a large well-characterized urban minority patient population. The core assists in the development, design, and performance of studies that transition basic research to the bedside and at the same time foster the transition of clinical observations and hypotheses to the laboratory. This Core further interacts with the International HIV Medicine and Research Core to provide training in advanced HIV care and neurocognitive assessment that can be used at the international site to both improve the quality of patient care and also to perform meaningful neurocognitive assessment that benefits patients as well as the research community.. ...
Access a targeted collection of scientific application notes, case studies, videos, webinars, and white papers for clinical and translational research.
The aim of this research topic is to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life. CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial, but commonly involves hypoxia in premature babies, or perinatal strokes. Corticospinal axons have just invaded the spinal grey matter and thalamic afferents the upper layers of the neocortex, and these systems are undergoing activity dependent development. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry including heteronymous and hyperexcitable reflexes, and uprated ipsilateral corticospinal inputs that are not functionally useful. CP may be viewed
NIMH held this multidisciplinary workshop to identify major trends, gaps, and opportunities in clinical and basic research on repetitive behavior and resistance to change in autism.
Imaging genomics has increasingly moved towards a GWAS approach, using large-scale collaborations to improve power for the detection of variants with small independent effects [29]. Examples of such consortia include the Enhancing Neuro-imaging through Meta-analysis (ENIGMA) consortium [37], Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium [36], Alzheimers Disease Neuroimaging Initiative (ADNI), IMAGEN, which is focused on adolescents [38], and the Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium [39]. The growing number of GWAS of brain phenotypes and of neuropsychiatric disorders has, on occasion, lent support to previously reported candidate variants [40], but importantly has identified many new variants of interest [41].. An early study by the ENIGMA consortium consisted of approximately 8000 participants, including healthy controls and cases with psychiatric disorders [42]. This study identified significant associations between ...
Cerebral palsy (CP) is defined as a group of permanent disorders of the development of movement and posture, causing activity limitation, attributed to non-progressive disturbances occurring in the developing fetal or infant brain(1). Lesions to the sensorimotor cortex, subcortical axon tracts and subplate are often implicated, with other motor and non-motor areas frequently also affected. The aetiology is complex and often multifactorial (2); causes include hypoxia(3), stroke(4) , infection(5), trauma and genetic factors(6). By the end of the second trimester, corticospinal axons have invaded the spinal grey matter and thalamic afferents the upper layers of the neocortex (7, 8). These systems undergo activity-dependent development (9, 10). After early brain injury, descending pathways are disrupted, with abnormal development of reflex and corticospinal circuitry (11, 12). Movement abnormalities are initially subtle but develop subsequently (13, 14). Aberrant post-lesional plasticity undoubtedly
Preterm labour continues to be a major contributor to neonatal and infant morbidity. Recent data from the USA indicate that the number of preterm deliveries (including those associated with preterm labour) has risen in the last 20 years by 30%. This increase is despite considerable efforts to introduce new therapies for the prevention and treatment of preterm labour and highlights the need to assess research in this area from a fresh perspective. In this paper we discuss i) the limitations of our knowledge concerning prediction, prevention and treatment of preterm labour and ii) future multidisciplinary strategies for improving our approach.
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder with monogenic mutations setting the stage for successful gene therapy treatment. We have completed a study that directly deals with the following key issues that can be directly adapted to a gene therapy clinical trial using rAAV considering the following criteria: 1) A regional vascular delivery approach that will protect the patient from widespread dissemination of virus; 2) an approach to potentially facilitate safe passage of the virus for efficient skeletal muscle transduction; 3) the use of viral doses to accommodate current limitations imposed by vector production methods; 4) and at the same time, achieve a clinically meaningful outcome by transducing multiple muscles in the lower limb to prolong ambulation. The capacity of AAV1, AAV6 or AAV8 to cross the vascular endothelial barrier carrying a micro-dystrophin cDNA was compared under identical conditions with delivery through a catheter placed in the femoral artery of the mdx
Objectives: Toll like receptor (TLR) signaling emerged as a significant pathway in our whole genome peripheral blood study of ischemic stroke patients. In our dataset, TLR signaling is associated with stroke severity, can predict outcome and is influenced by age. The age-mediated effects on TLR expression and kinase signaling in response to cerebral ischemia are not well-characterized. The objective of this project was to confirm and further characterize our clinical findings in a preclinical aged stroke model by analyzing TLR gene expression and the kinase proteome.. Methods: An SaBiosciences rat TLR PCR array was used to compare brain and blood gene expression in 3 (n=3) and 18 (n=3) month old rats that underwent embolic middle cerebral artery occlusion (MCAO) with tPA reperfusion and sacrificed at 24 hours. Blood samples were collected via femoral artery in Qiagen RNA protect tubes. Rats were perfused and then Brain tissue was collected in RNA later. A Kinetworks Protein Kinase Screen 1.2 was ...
Research funding agencies, industry and academic institutions have placed increased attention to the issue of ensuring research methods and results are reproducible. Irreproducible data poses a danger to the fundamental mission and promise of translational science, and data reproducibility should be considered as integral to the translational research process. This session will present approaches, tools and best practices to integrate data reproducibility and rigor into translational research programs. Additionally, key federal policies and initiatives impacting data quality and rigor will be discussed ...
The Institute for Translational Medicine and Therapeutics (ITMAT) supports research at the interface of basic and clinical research focusing on developing new and safer therapeutics. ITMAT includes faculty, basic research space, and the Clinical and Translational Research Center (CTRC), which derives from the integration of the former General Clinical Research Center (GCRC) of both Penn and the Childrens Hospital of Philadelphia (CHOP). ITMAT also offers research cores, educational programs (including a Masters in Translational Research), and research programs and centers. These are designed to facilitate training and research from proof of concept in cellular and animal model systems across the translational divide to proof of concept and dose selection in humans.
The Institute for Translational Medicine and Therapeutics (ITMAT) supports research at the interface of basic and clinical research focusing on developing new and safer therapeutics. ITMAT includes faculty, basic research space, and the Clinical and Translational Research Center (CTRC), which derives from the integration of the former General Clinical Research Center (GCRC) of both Penn and the Childrens Hospital of Philadelphia (CHOP). ITMAT also offers research cores, educational programs (including a Masters in Translational Research), and research programs and centers. These are designed to facilitate training and research from proof of concept in cellular and animal model systems across the translational divide to proof of concept and dose selection in humans.
Accelerating Research to Improve Health. The UCSF Clinical and Translational Science Institute (CTSI) is part of the Clinical and Translational Science Award (CTSA) program funded by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) (Grant Number UL1 TR991872). The content of this website is solely the responsibility of CTSI and does not necessarily represent the official views of the NIH.. Cite CTSI NIH Funding Acknowledgment: Important - All publications resulting from the utilization of CTSI resources are required to credit the CTSI grant by including the NIH Funding acknowledgment and must comply with NIH Public Access Policy.. ...
This Clinical and Translational Science Awards (CTSA) Consortium website is funded by the U.S. National Institutes of Health, grant 1U54RR032646-01 ...
Malignant mesothelioma is a cancer refractory to current therapies. Imatinib Mesylate (STI571, GlivecTM) is a selective inhibitor of tyrosine kinases as bcr-abl, c-Kit, c-Fms and Platelet Derived Growth Factor Receptorβ (PDGFRβ). PDGFRβ is often overexpressed in mesothelioma cells and is a therapeutic target for Imatinib in some solid tumors. The aim of this study is to assess whether Imatinib alone or combined with chemotherapeutic agents may be successful for mesothelioma therapy. Cultures from mesothelioma MMP, REN and ISTMES2 cell lines, were treated with Imatinib alone or in combination with chemotherapeutic. We show here that Imatinib induces cytotoxicity and apoptosis selectively on PDGFRβ positive mesothelioma cells, via blockade of receptor phosphorylation and interference with the Akt pathway. Among chemotherapeutics tested in combination, Imatinib synergizes with Gemcitabine and Pemetrexed. We provide a rationale for a novel translational approach to mesothelioma therapy, relying ...
Exciting opportunity in Nashville, TN for Vanderbilt Health as a Clinical Translational Research Coordinator II - Cognitive/Behavioral Neurology
Rockefeller Universitys Center for Clinical and Translational Science, established a decade ago to accelerate the pace of translating scientific discoveries into interventions shown to improve health, has received $27 million from the National Institutes of Health to fund ongoing and expanded work over the next five years. The Clinical and Translational Science Award (CTSA), which has funded the center since its inception, is designed to improve the translational research process and foster innovation in research methods, training, and career development.. The award maintains CTSA funding that began in 2006, when Rockefeller was selected as one of the first 12 institutions to receive it, and then continued through the universitys successful renewal in 2011. With this award, which is technically not a renewal, Rockefeller has received more than $115 million in CTSA funding.. Im delighted that we will continue to be funded through the CTSA, says Center for Clinical and Translational Science ...
http://sig3perspectives.pubs.asha.org/article.aspx?articleid=1777062 From Bench to Bedside: Translational Research on Vocal Fold Hydration The importance of well-hydrated vocal folds in maintaining optimal voice function is widely acknowledged. In this article, we summarize findings from recent bench and bedside research and highlight how use of these experimental techniques has improved our understanding of the physiological mechanisms that regulate vocal fold hydration. ... 2008-11-01T00:00:00 Article Mahalakshmi Sivasankar ...
W Michael Foster Jiurong Liang Eric B Meltzer Dianhua Jiang Robert J Lefkowitz Paul W Noble Science Translational Medicine 16 Mar 2011 74ra23 The signaling molecule β arrestin is required for the fibroblast invasion of extracellular matrix and thus for the development of pulmonary fibrosis Editor s Summary Abstract Full Text PDF The Δ F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis Like Disease in Pigs By Lynda S Ostedgaard David K Meyerholz Jeng Haur Chen Alejandro A Pezzulo Philip H Karp Tatiana Rokhlina Sarah E Ernst Robert A Hanfland Leah R Reznikov Paula S Ludwig Mark P Rogan Greg J Davis Cassie L Dohrn Christine Wohlford Lenane Peter J Taft Michael V Rector Emma Hornick Boulos S Nassar Melissa Samuel Yuping Zhang Sandra S Richter Aliye Uc Joel Shilyansky Randall S Prather Paul B McCray Jr Joseph Zabner Michael J Welsh David A Stoltz Science Translational Medicine 16 Mar 2011 74ra24 A common mutation in human cystic fibrosis CFTR ΔF508 results in misprocessed CFTR and a ...
The universitys new Clinical and Translational Science Institute plans to add clinician-scientists and cooperate with other core research centers with the aim of becoming a member of NIHs Clinical and Translational Science Awards consortium.
The vaginal distention (VD) translational model for postpartum stress urinary incontinence (SUI) is potentially biased for use in evaluating animals with increasing phenotypic size (obesity) due to a fixed VD volume. Our study had three principle and two secondary aims. First, to examine both ex vivo and in vivo catheter pressure changes during volume distention. Secondly, to determine mean pressure at current volume standard for use as target pressure (TP) for VD under isobaric (IB) conditions. Thirdly, to demonstrate feasibility and equivalence of VD at TP versus isovolumetric (IV) standard. Secondary aims were to demonstrate decreased variability (IB vs. IV) and to review the effect of weight. ...
The Clinical Research Education and Career Development Program (CRECD) at MSM is pleased to announce that a record number of six scholars were sponsored to attend and present their research at the Association of Clinical Research Training/Society of Clinical and Translational Science (ACRT/SCTS) Joint Annual Scientific Sessions this week in Washington DC. Two scholars, Djana Harp, MD, MS and Baraka Floyd (MD and MS candidate) were research award winners and Lilly Immergluck, MD was a travel award winner. According to Alexander Quarshie, MD, who participated as a poster judge, this was a very competitive process and award winners had to be judged as excellent by three independent judges. Congratulations to these scholars and their mentors, and to the research award winners:. ...
The Community-Based Clinical Research Centers are supported by the William T. Dahms, MD Clinical Research Unit (DCRU) and utilize the research network of the Cleveland Clinical & Translational Science Collaborative of Cleveland (CTSC), UL1TR000439, from the National Center of Advancing Translational Sciences (NCATS) component of the National Institutes of Health, to expand clinical/translational research resources available to both academic and community-based research programs. The Dahms Clinical Research Unit is a joint effort with the Case Western Reserve University School of Medicine ...
Supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award number UL1TR002378. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. KL2 Scholars should also list KL2TR002381 and TL1 Trainees should also list TL1TR002382 ...
Dr. Cellucci is an Associate Professor in the Department of Pediatrics, Division of Rheumatology. She completed her medical degree and subsequent fellowships in Rheumatology at the University of Toronto and The Hospital for Sick Children, and pursued her postgraduate training in pediatrics at Western University. While completing her research fellowship at Sick Kids, she worked as a locum physician in pediatric rheumatology at Albertas Childrens Hospital in Calgary.. As an investigator, Dr. Celluccis interests are in the field of childhood inflammatory brain diseases. Her most recent study focuses on developing a knowledge translation intervention to build physician knowledge about childhood CVS vasculitis, and promote practice change.. In addition to her research, she is currently completing a Masters of Science in Community Health in the Health Practitioner Teacher Education Program at the University of Toronto, with a focus on knowledge translation for rare diseases. Recently, she led a key ...
The CTRC provides infrastructure, resources, and dedicated space to conduct clinical research. Available resources include a staff physician, research nursing, exercise physiologist, bionutritionist, pharmacy services, statistics, and adverse event management. Our services are provided on a fee for service basis. You can find a price list of our most common procedures below. Some procedures are subject to change based on protocol specifics. Please contact the CTRC Administrator for more information.. In compliance with University policy we conduct a price assessment every fiscal year, our current prices are valid until June 30th. When budgeting for a new project it is recommended that you add 6% to account for any inflation that may occur.. ...
Other authors of the paper (Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling) were lead author and postdoctoral fellow Kyle Timmerman, medical student Jessica Lee, assistant professor Hans Dreyer, research scientist Shaheen Dhanani, graduate students Erin Glynn and Christopher Fry, assistant professor Micah Drummond, associate professor Melinda Sheffield Moore, and professor Blake Rasmussen. Specialized metabolic studies were conducted by the staff of the UTMB Clinical Research Center, part of the universitys Institute for Translational Sciences. The National Institute on Aging, the UTMB Claude D. Pepper Center Older Americans Independence Center, the National Institute of Child Health and Human Development and the UTMB Clinical Translational Sciences Award supported this study. ...
Although the CTSA program is young, there have already been examples that show how partnering with CTSA researchers can benefit pharmaceutical companies. One is the Yale Clinical trial network, which should streamline and improve the clinical trials process for the companies that are part of it. Among other goals, the network will remove barriers to clinical trials and promote trial participation. There is also at least one example of a cross licensing agreement between a CTSA funded researcher and industry. Dr. Daniel Rader, at the University of Pennsylvania, took advantage of his universitys CTSA to develop an MTP inhibitor that was very effective in treating a rare disease called familial hypercholesterolemia. Seeing the potential of lower doses of the drug to treat patients at risk of heart disease, Aegerion Pharmaceuticals is developing the drug for this purpose.. ...
Supported by US National Institutes of Health Clinical Translational Science Award 1 KL2 RR024151-01 (Mayo Clinic Center for Clinical and Translational Research), and the resources and facilities at the Birmingham VA Medical Center, Alabama, USA. The original study was supported by unrestricted grants to scientific societies (Osteoarthritis Research Society International and Outcome Measures in Rheumatology) from pharmaceutical companies: Pfizer, Expansciences, Novartis, Negma Lerads, Rottapharm, Fidia, and Pierre Fabre Santé laboratories, and a research grant from the European League Against Rheumatism. Dr. Suarez-Almazor is the recipient of a K24 award from the National Institute for Arthritis, Musculoskeletal, and Skin Disorders (AR053593). Dr. Singh has received research and travel grants from Takeda and Savient, and consultant fees from Savient, Regeneron, Takeda, and Allergan. ...
Professor Jacob George and his team are committed to reducing the burden of liver cancer on NSW. He says there is still a long way to go, but there are promising signs.. Modelling from the Kirby institute demonstrates that in NSW, since the introduction of the new hepatitis C treatments, the increasing burden of liver cancer has plateaued.. Projections show liver cancer incidence state-wide will decline over the next few years with increasing treatment coverage, Professor George explains.. To help achieve this goal, Western Sydney Local Health District has officially launched a mobile van to make hepatitis C testing much easier and faster.. The van is offering free blood collection and blood spot testing for hepatitis C by specialist staff, along with HIV testing.. The van will be in Paramatta for two furter dates in June and August, and Castle Hill in September. See the Liver Wellness Program for more information.. ...
Current list of Benefactor-Funded Research Career Development Awards available through Mayo Clinics Center for Clinical and Translational Science (CCaTS).
The Translational Science of Rare Diseases - From Rare to Care III , Endo-ERN, The Translational Science of Rare Diseases - From Rare to Care III symposium, hosted by the BMBF-funded German Research for Rare network, will take place from April 11 to 13,
Despite phenomenal progress in basic science, we still lack effective treatments for far too many diseases, and this translational pipeline to get there is long, 14 years on the average, and its leaky, said NIH Director Dr. Francis Collins during congressional testimony on March 20. Both Collins and NCATS Acting Director Dr. Thomas Insel testified on the Presidents FY 2013 budget request before the U.S. House of Representatives Appropriations Subcommittee on Labor, Health and Human Services, Education, and Related Agencies, chaired by Rep. Denny Rehberg (R-MT).. The hearing focused on both the NIH and NCATS budgets and featured panel discussions about the many opportunities that exist for NCATS to work in synergy with private industry to improve the translation process. Collins also restated NIHs commitment to fund basic biomedical research as its highest priority. Insel showcased NIHs Clinical and Translational Science Awards program, saying 80 percent of [the NCATS] budget is the CTSA ...
Columbia University Medical Centers (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of fac...
Rajita Sinha, Ph.D. is the Foundations Fund Professor in the Department of Psychiatry at Yale University and also Professor of Neurobiology and Child Study. She is Chief of the Psychology section in Psychiatry and Co-Director of Education at the Yale Center for Clinical Investigation (the Yale Clinical Translational Science Award). She is the Founding Director of the Yale Stress Center, a university-wide center that focuses on understanding the effects of stress on emotions, mood and behavior, in order to improve health outcomes relating to choices and maladaptive behaviors. She is internationally known for her pioneering research on the mechanisms linking stress, emotions to addictive behaviors and health outcomes. Her research is making discoveries on the link between stress, mechanisms like glucocorticoids, immune adaptations and effects on brain structure, function and its impact on bheaviors, decisions and chronic disease risk. She is also developing and testing new pharmacological and ...
The Community-Based Clinical Research Centers are supported by the William T. Dahms, MD Clinical Research Unit (DCRU) and utilize the research network of the Cleveland Clinical & Translational Science Collaborative of Cleveland (CTSC), UL1TR000439, from the National Center of Advancing Translational Sciences (NCATS) component of the National Institutes of Health, to expand clinical/translational research resources available to both academic and community-based research programs. The Dahms Clinical Research Unit is a joint effort with the Case Western Reserve University School of Medicine ...
The Department of Biostatistics is responsible for the development and delivery of the postgraduate statistics teaching programme for PhD students in the Faculty of Health and Life Sciences, a new research strand, Biostatistics and Bioinformatics, in the MRes in Biomedical Sciences and Translational Medicine Master Course, a new MSc in Clinical Research Administration in partnership with Laureate Online Education (http://www.liv.ac.uk/study/online/index) and a number of CPD courses that are designed to provide healthcare professionals with basic statistical research skills.. ...
TY - JOUR. T1 - Adding Social Determinant Data Changes Childrens Hospitals Readmissions Performance. AU - Sills, Marion R.. AU - Hall, Matthew. AU - Cutler, Gretchen J.. AU - Colvin, Jeffrey D.. AU - Gottlieb, Laura M.. AU - Macy, Michelle L.. AU - Bettenhausen, Jessica L.. AU - Morse, Rustin B.. AU - Fieldston, Evan S.. AU - Raphael, Jean L.. AU - Auger, Katherine A.. AU - Shah, Samir S.. N1 - Funding Information: M.S. supported by the National Heart, Lung, and Blood Institute (5R21HL123589-02), the Health Resources and Services Administration, Maternal Child Health Research Program (R40-111810) and the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program (UL1 TR001082). G.C. supported by Childrens Hospitals and Clinics of Minnesota, the Medica Research Institute and National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program (UL1TR000114). E.F. Funded by the Agency for Healthcare Research and Quality (1R01HS023538-A1). ...
TY - JOUR. T1 - Defining disease, diagnosis, and translational medicine within a homeostatic perturbation paradigm. T2 - The National Institutes of Health undiagnosed diseases program experience. AU - Gall, Timothy. AU - Valkanas, Elise. AU - Bello, Christofer. AU - Markello, Thomas. AU - Adams, Christopher. AU - Bone, William P.. AU - Brandt, Alexander J.. AU - Brazill, Jennifer M.. AU - Carmichael, Lynn. AU - Davids, Mariska. AU - Davis, Joie. AU - Diaz-Perez, Zoraida. AU - Draper, David. AU - Elson, Jeremy. AU - Flynn, Elise D.. AU - Godfrey, Rena. AU - Groden, Catherine. AU - Hsieh, Cheng Kang. AU - Fischer, Roxanne. AU - Golas, Gretchen A.. AU - Guzman, Jessica. AU - Huang, Yan. AU - Kane, Megan S.. AU - Lee, Elizabeth. AU - Li, Chong. AU - Links, Amanda E.. AU - Maduro, Valerie. AU - Malicdan, May Christine V.. AU - Malik, Fayeza S.. AU - Nehrebecky, Michele. AU - Park, Joun. AU - Pemberton, Paul. AU - Schaffer, Katherine. AU - Simeonov, Dimitre. AU - Sincan, Murat. AU - Smedley, ...
BioSiteHistos services were acknowledged and made the front cover of the March Issue of Stem Cells Translational Medicine. Of special note is that two of our reliable Optibodies™ were used for the histology part of the study.. Improved quality of life is a major goal for treatment of pelvic floor disorders such as anal incontinence that can be a result of sphincter injury. In the study it was observed that the functional measurements showed improvement in treated groups as compared with controls. In the original article, from authors at Tampere University Hospital, University of Tampere and Tampere University of Technology the functional outcomes of human adipose stem cell (hASC) injections in a rat model were studied. It was also found that Bulkamid is a suitable carrier for stem cells and that a novel method of micro-computed tomography was useful for targeting the histological slides.. The article is available as open access and you can read the full article here. References ...
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We are seeking a highly motivated and enthusiastic associate to join our pre-sampling team in the Translational Medicine group. The position will involve direct handling and processing of highly valuable clinical specimens from our external collaborators as well as tracking work in a laboratory inventory management system (LIMS). This contractor will also be required to store samples appropriately, potentially assist with nucleic acid extractions, and assist in a variety of other lab organizational tasks to ensure efficient and organized processing of patient samples ...
The UR CTSI is dedicated to engaging the community at all stages of research. Community engagement helps health research address community needs and is a philosophy that supports partnership between community and academics to develop strategies that address those needs. At the UR CTSI, we train researchers and community members to work together and provide funding to support and advance these partnerships.. ...
The Knowledge Translation for Employment Research Center (KTER) develops and tests knowledge translation strategies designed to help vocational rehabilitation agencies and businesses find, understand, and use research related to employing people with disabilities.
Introduction TRECARD promises to respect any personal data you share with us, or that we get from other organisations and keep it safe. We aim to be clear when we collect your data and not do anything you wouldnt reasonably expect. Developing a better understanding of our supporters through their personal data allows us…
TY - JOUR. T1 - Patient and physician views of shared decision making in cancer. AU - Tamirisa, Nina P.. AU - Goodwin, James S.. AU - Kandalam, Arti. AU - Linder, Suzanne K.. AU - Weller, Susan. AU - Turrubiate, Stella. AU - Silva, Colleen. AU - Riall, Taylor S.. N1 - Funding Information: Funding information Cancer Prevention Research Institute of Texas Grant # RP140020, UTMB Clinical and Translational Science Award # UL1TR000071, NIH T-32 Grant # T32DK007639, AHRQ Grant # 1R24HS022134, and NIH Grant # K05-CA 134923 This study is dedicated to the memory of Suzanne Kneuper Linder, Ph.D. (8 January 1977-9 October 2014). She was a major contributor to this study. Her passion for qualitative research and dedication to improving physician?patient communication served as an example to all who worked with her. Funding Information: Cancer Prevention Research Institute of Texas Grant # RP140020, UTMB Clinical and Translational Science Award # UL1TR000071, NIH T-32 Grant # T32DK007639, AHRQ Grant # ...
The NIH Broadening Experiences in Scientific Training (BEST) program is designed to develop innovative approaches to prepare students and postdocs for a range of careers. As part of the University of Rochester (UR BEST) Science and Technology Policy Pathway, trainees interested in the Regulatory Science and Personalized Medicine Track will learn key competencies in Regulatory Science and Personalized Medicine through internships and experiential opportunities that prepare them for careers at the FDA, NIH, Centers for Disease Control and Prevention (CDC), pharmaceutical and medical device industry, academic institutions and a range of other government agencies and NGOs. Participants interested in the management and oversight of science can explore opportunities in the Regulatory Affairs Compliance and Review Pathway.. ...