Under section 8 in the Annexes of the information, required Toxicological Information is outlined. In section 8.4, Mutagenicity testing assays are listed, which call for a tiered approach to toxicological assessment of substances. Further, under section 8.5 and 8.6 Acute Toxicity and Repeated Dose Toxicity assays are noted. Although the approach and procedures for testing are outlined, the interpretation of results and navigation of testing options requires expertise and experience. BioReliance has assembled the foremost collection of scientists available anywhere and thus you can rely on us to assist in your REACH testing needs ...
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris Internationals efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers ...
Read chapter 9 Effects of Jet-Propulsion Fuel 8 on Reproduction and Development: This report provides a critical review of toxicologic, epidemiologic, an...
Development of a rapid, sensitive and cost-effective method for toxicity assessment of commonly used nanoparticles is urgently needed for the sustainable development of nanotechnology. A neural cell with high sensitivity and conductivity has become a potential candidate for a cell chip to investigate toxicity of environmental influences. A neural cell immobilized on a conductive surface has become a potential tool for the assessment of nanotoxicity based on electrochemical methods. The effective electrochemical monitoring largely depends on the adequate attachment of a neural cell on the chip surfaces. Recently, establishment of integrin receptor specific ligand molecules arginine-glycine-aspartic acid (RGD) or its several modifications RGD-Multi Armed Peptide terminated with cysteine (RGD-MAP-C), C(RGD)4 ensure farm attachment of neural cell on the electrode surfaces either in their two dimensional (dot) or three dimensional (rod or pillar) like nano-scale arrangement. A three dimensional RGD modified
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
A disk-shaped thin plate or a long-sized thin plate having a roll appearance housed in a casing in which openings for penetration of test substance are formed and on which diffusion-limiting membranes are adhered to cover each openings. Also a driving mechanism for moving the thin plate is provided with the casing. The casing thus houses the thin plate and is provided with the driving mechanism and is positioned in a test apparatus body having a concentration measuring electrode therein. Multiple measurments of concentration of a test substance are carried out by moving the thin plate by the driving mechanism to position the diffusion-limiting membrane having the test solution deposited thereon to the position available to contact with the concentration measuring electrode, while keeping the casing placed in the test apparatus body. As a result, a plurality of measurements of concentration of the test substance is carried out easily.
As science progresses, new methods are developed to accomplish tasks. Some help medical and agricultural science work faster, others allow completely news ways of doing things. In the business of promoting new crop traits, CRISPR is one example of a revolutionary new technology that opens up new avenues. But it isnt the only one. In […]. ...
Description. The goal of 3.044 is to teach cost-effective and sustainable production of solid material with a desired geometry, structure or distribution of structures, and production volume. Toward this end, it is organized around different types of phase transformations which determine the structure in various processes for making materials, in roughly increasing order of entropy change during those transformations: solid heat treatment, liquid-solid processing, fluid behavior, deformation processing, and vapor-solid processing. The course ends with several lectures that place the subject in the context of society at large. The goal of 3.044 is to teach cost-effective and sustainable production of solid material with a desired geometry, structure or distribution of structures, and production volume. Toward this end, it is organized around different types of phase transformations which determine the structure in various processes for making materials, in roughly increasing order of entropy ...
Volume weighed percent positive (VWPP) - The VWPP for a specific product-pathogen pair is calculated by combining the production volumes (production volume can be defined as the amount (weight or numbers of head) of product produced per year) for establishments with their sampling results. This provides a more accurate estimation than a percent positive, but the data do not meet the statistical requirements to make a prevalence estimate. VWPP is more public health focused than PP, in that weighting results by volume reflects exposure of the public to specific pathogens ...
BMWs new era of sports cars will commence in June when the $135,700 BMW i8 plug-in hybrid goes on sale.. The launch date was announced with minimal fanfare on the BMW USA website, and while examples of the 362hp carbon fiber car will touch down in BMW dealerships, they wont stay for long as every one is allegedly already spoken for.. Production volumes will be modest for 2014, wi More. BMWs new era of sports cars will commence in June when the $135,700 BMW i8 plug-in hybrid goes on sale.. The launch date was announced with minimal fanfare on the BMW USA website, and while examples of the 362hp carbon fiber car will touch down in BMW dealerships, they wont stay for long as every one is allegedly already spoken for.. Production volumes will be modest for 2014, wi More. […]. ...
ACToR was developed to support the ToxCast program of the EPA National Center for Computational Toxicology (NCCT). ToxCast develops faster methods to evaluate the potential toxicity for thousands of chemicals using computer modeling and advanced molecular biology techniques. ACToR was used to analyze toxicity information on almost 10,000 chemicals regulated by EPA and to identify data gaps to be addressed by ToxCast, which will greatly help EPA prioritize future testing of chemicals. Key findings are that while acute toxicity data is available for 59 percent of the surveyed chemicals, detailed testing information is much more limited. Twenty-six percent of the 10,000 chemicals have carcinogenicity testing data, 29 percent have developmental toxicity testing data, and 11 percent have complete reproductive toxicity test results ...
DNEL derivation is based on a 90-day toxicity study by inhalation administration to rats (Triel, 2017). The starting dose for DNEL calculation is a NOAEC of 208 mg/m3 (25.1 ppm). Considering a ventilation rate of 0.29 m3/kg for a 6-hour exposure and a default inhalation absorption of 50%, the corresponding internal NOAEL is 30 mg/kg bw/d. TDM is expected to be well absorbed by the oral route (100% of the dose), therefore the oral NAEL derived for general population is 30 mg/kg bw/d ...
... BEIJING April 18 /- BioDuro & The National Center fo...Dean Rodwell BioDuros Vice-President of Toxicology stated Although...Dr. Li Bo from the National Institute for the Control of Pharmaceutica...The Centers main tasks are to carry out the toxicological tests andp...,BioDuro,&,The,National,Center,for,Safety,Evaluation,of,Drugs,Received,Full,AAALAC,Accreditation,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Washington, D.C. - Riding the wave of the future, EPAs ToxCastTM program looks to revolutionize the agencys chemical toxicity evaluation procedures.  ...
The aim of this Challenge was to develop and characterise non-mammalian assays to provide an indication of developmental and reproductive toxicity potential to mammals, including man, in order to reduce and refine in vivo mammalian testing. To address this Challenge, the team at the Institute for Risk Assessment Sciences/ Toxicology, led by Professor Raymond Pieters, have formed a company called Vivaltes that offers a service pipeline for toxicological assessments using non-mammalian species.
Newcells Biotech Ltd has developed an in vitro model of the retinal pigmented epithelium, to assess the safety and efficacy of novel ocular compounds. This technology could better predict the outcome in the human eye and reduce the number of animals used to assess the toxicity of ocular drugs. An end-user pharmaceutical company, able to provide access to ocular compounds and data with known in vivo/in vitro toxicity profiles, is sought to validate the model.
How to use a panel of response element vectors targeting the key pathways involved in the cellular stress response. These vectors can be incorporated into diverse cell model systems to predict specific target site toxicities and create chemical stress signatures for specific classes of compounds.
Driven by wide recognition that target tissue (or cell) dose is the most appropriate metric of dose for risk and safety assessment, there has been continued growth in the development of computational tools for estimating target tissue dose in vivo for a wide range of materials: volatile and non-volatile materials [42-44] organic chemicals [45, 46], pharmaceuticals [47, 48], and particulates and ultrafine particulates [49-53]. It is surprising, then, given the growing importance of in vitro studies to chemical and particle risk assessment [10] that few efforts [43, 54-56] have been directed at developing computational models of dosimetry for in vitro systems. In part, this oversight may be the result of the incorrect belief that in contrast to in vivo, there are no important kinetic or other processes to consider when addressing the issue of target tissue dose in vitro. We have shown this assumption is not universally true for chemicals [54] and particulates, including nanomaterials [12]. Thus, ...
Injection molding is best suited for large production volumes. It is a high investment cost with a complex processing method, typically producing excess scrap.
trina allmax 255w Trina ALLMAX 255W Solar Module, model TSM-PD05.05, provides exceptional value for residential grid-tie & off-grid projects. One of the most versatile solar modules available, and in a power range & size that makes it easy to build systems with all the popular BOS components. Trina is also one of the top-ranked manufacturers in terms of both production volume, price, and ethics.
Our world-leading experts in fire chemistry, toxicity, and human behaviour are at the forefront of the development of National and International standards in the field ...
Experimental long-term toxicity data for the registered substance are not available. A 14-day toxicity value was calculated using the neutral organics structure-activity relationship in the ECOSAR computer program (Nabholz and Mayo-Bean, 2009) of EPISuite; the results of which are adequate for the purpose of classification and labelling and/or risk assessment. Validity and applicability of the QSAR are described in a document attached as background material to the QSAR endpoint study record. ...
Scientists are now closer to having the ability to determine what a safe dose of nanomaterials is to humans, thanks to a comprehensive study completed at PNNL.
A probabilistic ecological hazard assessment technique, chemical toxicity distributions, was used to examine the relative sensitivities of in vitro and in vivo assays for detecting estrogenicity, and to assess the hazards ...
This paper aimed to evaluate the test results of acute toxicity on effluent samples which were exempted from applying of ecotoxicity criteria. Total 316 effluent samples which were free from controlling of ecotoxicity regulation, were tested. Ratio of effluent samples which were exceeded the ecotoxicity criteria (TU > 1) indicated 23.7%. This ratio was a little bit higher than previous study (22.7%) on effluent samples which were controlled under ecotoxicity criteria. These results mean that our ecotoxicity management system is not appropriate and applying of ecotoxicity criteria to all effluent samples (82 industry categories) were needed in order to improve our ecotoxicity system. In addition, the same numeric criteria (TU 1 or 2) for all industry categories were proposed in consideration of these results. Ratio of effluent samples which exceeded the ecotoxicity criteria (TU > 1) with D. magna indicated 23.7%. However V. fischeri showed 14.6%. As a acute toxicity test organism, D. magna seemed ...
Article Methyl Isobutyl Ketone (MIBK) Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2012 - 2018. Methyl isobutyl ketone (MIBK) is a colorless organic compound naturally occurring in grapes, orange, and vinegar. MIBK can...
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test - four week repeated toxicity test;gami jakyak gamcho buja decoction (mecasin);herbal medicine;sprague-dawley rat;
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test;kpubs;kpubs.org
While direct toxicity assessment (DTA) is now widely recognised as a useful tool for environmental risk assessment, many existing tests fail to meet end-user needs. This article describes the significant progress made to the MICREDOX® DTA assay, developed at Lincoln Ventures Ltd, brought about by miniaturising this assay to a multi-well plate format combined with limiting current microelectrode transduction. The benefits have been reduced: preparation time, reduced assay time, lower material costs and a higher level of replication achieved. To validate the precision of the miniaturised format, the concentrations required to cause a 50% decrease in signal (EC50) by an archetypal group of toxicants, the chlorophenols, were determined using two terrestrial bacterial strains, Escherichia coli K12 and Klebsiella oxytoca 13183. The assay time was then reduced by stepwise adjustment of the incubation time, from 60 down to 5 min, and the EC50s reported by E. coli to each of the toxicants after 45, 30, ...
The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimized wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments has been banned; in other situations, the number of organisms tested has been dramatically reduced or the severity of the procedure refined. However, there is still a long way to go to achieve a complete replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is based not just on ethical considerations but also on reducing the cost of performing vertebrate ecotoxicity tests and in some cases on providing better information aimed at improving environmental risk assessments. The present Focus article provides an overview of the ...
Neurodegenerative properties of acrylamide were studied in vitro by exposure of differentiated SH-SY5Y human neuroblastoma cells for 72 h. The number of neurites per cell and the total cellular protein content were determined every 24 h throughout the exposure and the subsequent 96-h recovery period. Using kinetic data on the metabolism of acrylamide in rat, a biokinetic model was constructed in which the in vitro toxicity data were integrated. Using this model, we estimated the acute and subchronic toxicity of acrylamide for the rat in vivo. These estimations were compared to experimentally derived lowest observed effect doses (LOEDs) for daily intraperitoneal exposure (1, 10, 30, and 90 days) to acrylamide. The estimated LOEDs differed maximally twofold from the experimental LOEDs, and the nonlinear response to acrylamide exposure over time was simulated correctly. It is concluded that the integration of the present in vitro toxicity data with kinetic data gives adequate estimates of acute and ...
The Methyl Isobutyl Ketone Detection Tubes (2.5 to 130 ppm) features a range of 2.5-130 ppm, a detecting limit of 1.5 ppm, and a 1 year shelf life.
Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studie
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ASTM E724 : Standard Guide for Conducting Static Acute Toxicity Tests Starting with Embryos of Four Species of Saltwater Bivalve Molluscs
The Rio Grande River is the natural boundary between U.S. and Mexico from El Paso, TX to Brownsville, TX. and is one of the major water resources of the area. Agriculture, farming, maquiladora industry, domestic activities, as well as differences in disposal regulations and enforcement increase the contamination potential of water supplies along the border region. Therefore, continuous and accurate assessment of the quality of water supplies is of paramount importance. The objectives of this study were to monitor water quality of the Rio Grande and to determine if any correlations exist between fecal coliforms, E. coli, chemical toxicity as determined by Botsfords assay, H. pylori presence, and environmental parameters. Seven sites along a 112-Km segment of the Rio Grande from Sunland Park, NM to Fort Hancock, TX were sampled on a monthly basis between January 2000 and December 2002. The results showed great variability in the number of fecal coliforms, and E. coli on a month-to-month basis. Fecal
Video created by University of Illinois at Urbana-Champaign for the course Managerial Accounting: Tools for Facilitating and Guiding Business Decisions. After establishing goals, setting targets, and the budget, upper management uses variance ...
Aquatic toxicity tests were originally designed for individual compounds that are soluble and stable in water. For sparingly soluble substances that are not toxic at the solubility limit, the issue is whether tests should be performed with insoluble test substance present. Based on a literature evaluation of the physiology of uptake, it was concluded that only the dissolved fraction is available for uptake and that the insoluble test substance may introduce artifacts that aggravate data interpretation. Therefore, toxicity tests should be conducted only up to the solubility limit. Testing of volatile, unstable, or adsorptive substances is complicated by the ability to keep exposure concentrations relatively constant. For these, appropriate test protocols including adequate design of the dosing systems must be employed. For test medium preparation, physical methods and, where necessary, use of low concentrations of certain solvents are recommended to support handling and speed of dissolution. ...
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellular hypertrophy, cell proliferation, and, frequently in long-term (life-time) studies, hepatocarcinogenesis.
An anterolateral view (left side) of the blood supply of the male reproductive organs and lower limbs relative to the skeleton. The surface anatomy of the body is semi-transparent and tinted red. - Stock Image F002/2443
An anterior view of the blood supply of the male reproductive organs and lower limbs relative to the skeleton. The surface anatomy of the body is semi-transparent and tinted turquoise. - Stock Image F002/2809
According to the results of toxicokinetic assessment, the inhalation route is not considered further as exposure scenarios for test article do not indicate inhalative exposure to be the likely route of exposure to workers in production. However, an inhalative DNEL was derived based on the NOAEC (700 mg/m³), derived from a subacute read-across study on methyl salicylate, in which no toxic signs and no macroscopic or microscopic effects were seen following exposure to a saturated atmosphere within 28 days (7 hours exposure on 5 days/week). This NOAEC was adjusted to 1207 mg/m³taking into account molecular weight differences from ethyl salicylate to homosalate. The absorption rate from dermal route is assumed to be less than 10% and the absorption rate of oral route is considered to be 100%. Therefore, the oral NOAEL of 50 mg/kg bw/d for general toxicity of methyl salicylate derived in a 2-year carcinogenicity study is converted to an equimolar value of 86 mg/kg bw/d of homosalate and route to ...
The Tox21 partner agencies work together to develop, validate, and translate innovative in vitro HTS methods to characterize the impact of chemicals on key steps in toxicity pathways.. Data collected in the Tox21 initiative has been used to prioritize uncharacterized compounds for regulatory testing using both traditional and novel test methods. To more broadly address challenges in the field of toxicology, in 2018 Tox21 released a new strategic and operational plan (Thomas et al. 2018) that expands the focus of its research activities. New focus areas include expanding its portfolio of alternative test systems, addressing technical limitations of in vitro test systems, curating legacy in vivo toxicity testing data, establishing scientific confidence in in vitro test systems, and refining alternative methods for characterizing pharmacokinetics and in vitro assay disposition. The eventual goal of Tox21 is to use HTS methods to generate data that will allow risk assessors to more accurately ...
Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3-Azido-3-deoxythymidine (AZT) and Rifabutin Combinations (CASRNs 30516-87-1 and 72559-06-9) Administered by Gavage to Swiss (CD-1®) ...
Regulatory Toxicology and Pharmacology. 2014;68:275-296. Thousands of man-made chemicals in use today may enter the food chain. Some of these may result in human exposure, while no toxicological data may be available. The present manuscript illustrates a decision tree for risk assessors and managers to establish fast and reliable safety levels of concern associated with dietary exposures.. Thousands of man-made chemicals are in use today. Many of these compounds may enter the food chain and result in human exposure. Since toxicological information is limited or lacking for the vast majority of these chemicals, the assessment of their health significance is therefore difficult, but envisaged.. A decision tree has been developed taking into account practical application of in silico methods. Basic concepts of classical risk assessment have been integrated: 1) exposure assessment 2) hazard identification 3) hazard characterization and 4) risk characterization.. The present work indicates that if ...
This case study summarizes events relating to the death of a man with seizure disorder who, after evaluation by the county coroner, was evaluated for pesticide exposure via toxicological assessment.
The evaluation of endocrine active substances is currently under discussion. EU legislation demands extensive consequences for endocrine disruptors: biocides and pesticides containing endocrine disruptive substances may not be placed on the market. Endocrine active substances may be placed on the candidate list for authorisation on a case-by-case basis in the context of REACH. Currently, no standardised definition or evaluation criteria for endocrine disruptors exist in the EU. The previous goal to elaborate such criteria untill the end of 2013 has been postponed till October 2014. Endocrine disruptors and regulatory consequences are the topic of the next Advanced Course in Toxicology of the Working Group Regulatory Toxicology of the German Society of Toxicology (DGPT). This course takes place on 31 March 2014 as satellite activity of the annual conference of the DGPT in Hannover. FoBiG is presenting results of an actual project. You find the program and the registration form for the course ...
Animal models: The consensus is that regulatory toxicology studies should be performed in rodents, whereas other preclinical animal studies may be performed in other animal models. A summary of the relevance of different models (mdx mouse, grmd dog, non-human primate and pig) was provided.. Proof of concept/functionality data/evaluation of oncogenicity: Although proof of concept has to be based on the detection of a functional improvement in the animal model, this needs to be evaluated in the context of the drug in question. In some cases gene expression may be adequate for proof of concept, but functional improvement will have to be seen in a subsequent step. Questions over the percentage of dystrophin expression required, the lack of criteria for the evaluation of efficacy, and how to define the length of follow-up required to prove absence of oncogenicity were also discussed. Route of administration (intramuscular, intravenous, loco-regional) - choice / immune reactions: Overall, the choice ...
The most important benefit of this project is the experimental evaluation of all essential steps in the development and testing of adverse outcome pathways (AOP) for a diverse set of reproductive and non-reproductive toxicants. In contrast to human testing and the toxicity pathway concept, testing of the ecological counterpart is much further behind. However, in vitro testing using rainbow trout cells has a long history and coupled with the superior mechanistic understanding of physiological processes controlling dosimetry, provides an excellent model system for studying implementation of the AOP process. Thus, our results will be of benefit to future studies with other ecologically important models by providing guidance on important questions such as: When considering the pituitary- gonadliver (PGL) axis, to what extent can immortalized cell lines be used and must you control for gender and maturational stage specificity? Are multi- tissue differences in toxicant sensitivity significant enough ...
Enrollment will be limited 16 per batch, on first-come first-served basis within the purview of regional representation. The participants will have to bear the cost of Travel, accommodation and Food. Food and accommodation can be arranged on request, for which the approximate cost will be Rs. 5000/- per participant. Payment is to be made only after receiving intimation from MGDC about the selection. This mail of intimation contains details about the mode of payment ...
First, it is important to understand that EC50 (and IC50) values are not constants. There are numerous variables that impact these, and other, assay metrics. Consequently, these values can vary greatly between different assay types and between different related receptors. Regarding this last point: Neither ERα and ERβ, or TRα and TRβ, are simple iso-forms of each other; rather, they are all distinct receptors encoded by separate genes. As an example, the two ER proteins share only 45% sequence identity. If one includes conserved substitutions between the two amino acid sequences, the two receptors still display only 60% sequence homology. While the two ERs have evolved to bind the physiological activator 17β-estradiol, it would be quite surprising if these two different nuclear receptors had the same activation profiles within the cellular context. It is also worth noting that the two ERs display strikingly disparate ligand preferences and activation/inhibition profiles for many other ...
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
BioAssay record AID 165916 submitted by ChEMBL: In vitro toxicity against Burkitts lymphoma (B-cell) (Raji) at a concentration of 0.1 ug/ml.
Black phosphorus (BP) belongs to a group of 2D nanomaterials and nowadays attracts constantly increasing attention. Parallel to the growing utilization of BP nanomaterial increase also the requirements for the thorough comprehension of its potential impact on human and animal health. The aim of this study was to compare and discuss five assays commonly used for the cytotoxicity assessments of nanomaterials with a special focus on BP nanoparticles. A comprehensive survey of factors and pitfalls is provided that should be accounted for when assessing their toxicity and pointed to their inconsistency. BP might introduce various levels of interference during toxicity assessments depending on its concentration applied. More importantly, the BP toxicity evaluation was found to be influenced by the nature of assay chosen. These are based on different principles and do not have to assess all the cellular events equally. A commercial assay based on the measurement of protease activity was identified to ...
TSCA/HPV Chemical Testing:. On October 21, 2011, utilizing its authority under the Toxic Substances Control Act (TSCA), 15 U.S.C. §2601 et seq., EPA published two Federal Register notices announcing testing rules for certain high production volume (HPV) chemicals as well as significant new use rules (SNURs) for other HPV chemicals. HPV chemicals are those with a production/import volume equal to or greater than 1 million pounds (lbs) per year. The first notice promulgates a final testing rule for 15 HPV chemicals. The second notice adopts an innovative approach to regulating HPV chemicals, proposing a testing rule for 23 HPV chemicals and a SNUR for 22 others, along with an alternative proposal to regulate any of the 23 chemicals via a SNUR should public comments indicate a testing rule is unecessary. Additional details about the rules and the affected chemicals are provided below.. Final Test Rule. The first notice promulgates a final rule under section 4(a)(1)(B) that requires manufacturers, ...
At a test substance concentration of 13.3 mg/L (equivalent to 10 mg C/L) and a reference substance concentration of 10 mg C/L, the toxicity control attained >25% degradation by day 6, thereby confirming that the test substance did not exhibit an inhibitory effect on the sewage treatment micro-organisms used in the test (i.e., test substance and reference substance attained ≥ 25% degradation by Day 14 for the test substance to be considered as non-inhibitory ...
Each assay element is represented by a separate table in the tcpl database. In general, we refer to an "assay_component_endpoint" as an "assay endpoint." As we move down the hierarchy, each additional layer has a one-to-many relationship with the previous layer. For example, an assay component can have multiple assay endpoints, but an assay endpoint can derive only from a single assay component.. All processing occurs by assay component or assay endpoint, depending on the processing type (single-concentration or multiple-concentration) and level. No data are stored at the assay or assay source level. The "assay" and "assay_source" tables store annotations to help in the processing and down-stream understanding/analysis of the data. For more information about the assay annotations and the ToxCast assays, please refer to http://www.epa.gov/ncct/toxcast/.. Throughout the package, the levels of assay hierarchy are defined and referenced by their primary keys (IDs) in the tcpl database: ...
Leadscope, Inc. is the leading developer of database and predictive model software tools used in chemical toxicity assessment. Leadscope applications are employed by both regulators and industry toxicologists to genotoxic impurity risk under the ICH M7 guidelines.
Systemic Toxicity tests evaluate the generalized biological effects to organs and tissues following exposure to a medical devices, bio-material, or their extracts. The term systemic implies that the exposure occurs by one route and the toxic substance is carried to distant locations causing an adverse effect. Systemic toxicity is typically evaluated in studies of acute, sub-acute, sub-chronic, and chronic duration based on the devices intended exposure. ...
Systemic Toxicity tests evaluate the generalized biological effects to organs and tissues following exposure to a medical devices, bio-material, or their extracts. The term systemic implies that the exposure occurs by one route and the toxic substance is carried to distant locations causing an adverse effect. Systemic toxicity is typically evaluated in studies of acute, sub-acute, sub-chronic, and chronic duration based on the devices intended exposure. ...
Drepanostat (Hydroxylmethylbenzoic acid) is a sickle cell management drug which comes in 10mg capsules. Drepanostat inhibits the red blood cells sicklings, preventing the destruction of the sickled(ing) red blood cells whereby increasing the production volume of the foetal haemoglobin which results to lessened pain during crisis.. ...
A. Typical toxicology tests Toxicity studies are conducted to determine what type of hazard a substance may pose to an organism. Some of the adverse effects toxicity tests are looking for include: lethality, organ damage, cellular effects, mutagenicity (damage to DNA), reproduction and developmental defects and cancer. Toxicity studies can be broadly divided into several…
Reportstack announces that it has a new study on Thin Film and Printed Battery Market Shares and Forecasts, Worldwide, Nanotechnology 2011-2017. These products power sensors that are the base for smarter computing. The 2011 study has 505 pages, 164 tables and figures. Thin film batteries are evolving solid state technology that provides vast improvements in energy density and creates units that can be recharged 40,000 times, up from 200 times for traditional batteries. Thin film battery market driving forces include business inflection that is achieved by delivering smart computing technology that supports entirely new capabilities. Sensor networks are creating demand for thin film solid state devices. Vendors doubled revenue and almost tripled production volume from first quarter. Multiple customers are moving into production with innovative products after successful trials. A strong business pipeline has emerged with customer activity in all target markets. Vendors expect full-year revenue to ...
I have seen alot of feed back on this post and some good solutions to re-enforcing the scupper holes. My day job is a plastics engineer and mold maker, and I am very familier with rotomolding and insert/overmolding (a leading expert in the field of plastics and insert/overmolding). The solution below uses injection molded sleeve inserts (should be under $1.00 each in production volumes for the sleeves). The solution below can be used on your existing molds with no modification to the molds themselves, and should never leak. You can also expand on this solution to add bulkheads to the boat structure, as well as re-enforce the front AKA cross bar and Mirage drive structures as well as strengthening the bow structure (for the future jib). For development and small quantity purposes (used for product testing), the sleeves can be made from a rapid prototyping process called SLS (selective Laser Sintering) using glass filled nylon ( sleeve prototypes would cost around $50-$75 ea). There are also ways ...
Problem Background Passionate and innovative growers Constraints: - Small production volumes - Competition between growers in local market - Fragmented industry structure Domestic coordination required for increased viability and profitability of growers
Before, not a single project, based on ICO, had any relation to the real sector of economy. Our idea to update blockchain option towards the needs of the industrial sector was the first of its kind in a worldwide practice. ZrCoin project was organized for attracting funds with the aim of building an innovative zirconium dioxide concentrate factory. Usually, cryptocurrency within ICO is assured against expenses on mining or demand on itself; sometimes it correlates with some currency or gold. Though ZrCoins tokens are assured against final products: one coins cost is the same as of 1 kilogram of zirconium dioxide produced by us. We plan to launch zircon scrap recycling plant within Magnitogorsk (Chelyabinsk region) industrial platform. With the use of unique technology, we will obtain zircon concentrate and synthetic slag-forming mixture when recycling 1 ton of zircon refractories scraps. The monthly production volume will reach 400 tons of concentrate and 100 tons of mixture. The idea hit us ...
A second way for foaming melts directly is to add a blowing agent to the melt instead of injecting gas into it. Heat causes the blowing agent to decompose and release gas, which then propels the foaming process (Figure 3a).8 Shinko Wire Company, Amagasaki, Japan, has been producing foams in this way since 1986 with production volumes reportedly up to 1,000 kg per day. In a first step, about 1.5 wt.% calcium metal is added to an aluminum melt at 680 C. The melt is stirred for several minutes, during which its viscosity continuously increases by a factor of up to five because of the formation of calcium oxide (CaO), calcium-aluminum oxide (CaAl2O4), or perhaps even Al4Ca intermetallics, which thicken the liquid metal. Figure 3b shows the effect of stirring on the viscosity of aluminum melts with various calcium additions.9 After the viscosity has reached the desired value, titanium hydride (TiH2) is added (typically 1.6 wt.%), serving as a blowing agent by releasing hydrogen gas in the hot viscous ...
High-grade nitrogen purity: Up to 99.5%. The complete system: For pressures up to 350 bar. Powerful concept: With flow rates from 485 to 770 l/min. Controller with touch screen display: For user-friendly operation and monitoring. Mobile system frame: Can be transported with a forklift truck. The nitrogen generators in BAUERs SNG II series are enclosed, integrated and modular complete systems for nitrogen supply comprising ROTORCOMP screw compressors, nitrogen membrane and BAUER piston compressor. They are capable of generating pure nitrogen through a nitrogen membrane which provides the basis for high production volume and cost-effectiveness at low costs. The SNG II series is built from modules on a system frame. The frame makes it easy to adapt the system at any time to meet your individual customer requirements. ...
InfinityQS offers quality control solutions for manufacturing teams to facilitate higher production volumes and reduce quality and process problems. Real time SPC...
Algae Biosciences Corporation - a high-profile new entrant to the omega-3 fatty acid market - has unveiled detailed figures on anticipated production volumes after finalizing a deal to build the first phase of its new production facility near Holbrook in Arizona.
The USDA has submitted an information collection request (ICR) to the White House Office of Management and Budget focused on cellulosic production volume projections and efficient producer reporting.
It has previously been reported that the in vitro cytotoxic effects of water-soluble fullerene species are a sensitive function of their surface derivatization status. In a recent study, it was reported that doses of an aggregated form of underivatized C60, termed nano-C60, were 3?4 orders of magnitude more toxic to human dermal fibroblasts, lung epithelial cells, and normal
Humans are sexual, meaning that both a male and a female are needed to reproduce. Each is equipped with specific organs capable of producing specific cells needed to procreate. In conjunction with a womans reproductive organs, sexual intercourse can lead to the reproduction.
Results of an in vivo toxicology study, demonstrates that an Antibody Drug Conjugate or ADC generated using the proprietary SMARTag™ platform has a better toxicity profile than a conventional ADC.
EPA needs rapid and efficient methods to prioritize, screen and evaluate thousands of chemicals. EPAs Toxicity Forecaster (ToxCast) generates data and predictive models on thousands of chemicals of interest to the EPA. ToxCast uses high-throughput screening methods and computational toxicology approaches to rank and prioritize chemicals. In fact, EPAs Endocrine Disruption Screening Program (EDSP) is working to use ToxCast to rank and prioritize chemicals.. ...
Toxicological Principles for the Safety Assessment of Food Ingredients - Chapter IV.B.4. Statistical Considerations in Toxicity Studies
Hennig H.F K.O.; Greenwood P.J., 1981: The loss of cadmium and zinc from sea water during accumulation experiments its implication on toxicity threshold concentrations
sand replacement test method images and sand replacement test method products - 1095 sand replacement test method suppliers & manufacturers from China of page 2.
Chrysobalanus icaco L. is a native plant of Brazil used as a food source and traditionally for the treatment of various diseases. The aim of study was performed...
CASE Ultra models cover a wide variety of toxicity end points and is the largest collection of high quality in-silico toxicity models
This is the best online medical lectures site, providing high quality medical and nursing lectures for students across the globe. Our lectures are oversimpli ...
Page Test Methods - Page 28 of the all-in-one environmental test methods database at ALS Environmental, previously Columbia Analytical
The [email protected] Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access ...
A toxicology screen is a test that determines if someone has used certain legal or illegal drugs. Learn about toxicology screen types, procedure, and results.
The present clinical study aims to compare the efficacy, safety and dose-response with 12-week administration of TMG-123 with those of placebo in patients with
Keywords: areas of safety pharmacology growth, combined safety pharmacology and toxicology studies, safety pharmacology de-risking paradigms ...
Current Protocols in Toxicology is the best updated methods resource for accurate, efficient assessment of toxicity in whole organisms, organs and tissues, cells, and biochemical pathways.
Find the best toxicity and mold - removal service professionals in Ute, IA. See reviews, portfolios & more for the best toxicity and mold - removal contractors in Ute, IA.
Toxicity testing typically involves studying adverse health outcomes in animals subjected to high doses of toxicants with subsequent extrapolation to expected h...
All drugs are likely to have some side effects. Therapeutic monitoring of drugs is now readily available to make some of the drugs even safer.
All drugs are likely to have some side effects. Therapeutic monitoring of drugs is now readily available to make some of the drugs even safer.
Accuracy, discriminative properties and reliability of a human ESC-based in vitro toxicity assay to distinguish teratogens responsible for neural tube defects ...
E1440 - 91(2012) Standard Guide for Acute Toxicity Test with the Rotifer Brachionus , acute toxicity, cysts, freshwater, invertebrate, LC50, marine, rotifers, toxicity test,
E1295-01(2013) Standard Guide for Conducting Three-Brood, Renewal Toxicity Tests with Ceriodaphnia dubia three-brood toxicity test~ effluents~ Ceriodaphnia dubia~ cladocera~
The objective of the present study was to evaluate the pre-clinical efficacy and toxicity of polyherbal cough syrup Linkus. Method: Animals (healthy Wistar albino rats; (150 - 250 g) of either sex) were housed under standard environmental conditions; i.e. 25°C ± 1°C and 12 h dark/light cycle. Food and water were available at libitum. The rats were treated orally with the recommended doses of the test drug (Linkus). After 15 minutes, they were individually placed in a closed Plexiglas chamber (20 × 10 × 10 cm) and exposed to citric acid (0.1 g/ml) inhalation for 7 minutes. The cough reflexes were produced and counted for the last 5 minutes and compared with those of the control animals. The following studies were conducted to evaluate the toxicity of the test drug in healthy Wistar albino rats: lethal dose50 (LD50); rats of either sex (n = 10/sex) were treated orally with doses (1 or 5 g/kg) of the test drug. Mortality and behavioral changes were observed for 1 week. Repeated dose toxicity on the
We will utilize standard toxicologic assessment and high through-put toxicogenomic approaches, to gauge the relative toxicity of PM collected in regions where particles have greater and lesser effects on health outcomes. Project 3 will address potential limitations by integrating state-of-the-art genomic technologies with traditional and complementary toxicologic assessment. To exploit comparisons of pathobiologic cardiopulmonary responses to respirable airborne PM, in Phase I, we will optimize a battery of well-developed in vitro (human) and in vivo (murine) bioassays including multiple cytokines, indicators of reactive oxygen/nitrogen species burden (ROS/RNS), and biomarkers of vascular and cardiac dysfunction for assessing particle toxicity. For this purpose, we will use a set of particles having differing characteristics: standard NIOSH urban PM, Baltimore tunnel PM, ambient Baltimore air PM, New York City air PM. We will use oligonucleotide-based microarrays to address the hypothesis that ...
Current problems in the safety evaluation of chemicals, including species differences in chemical toxicity, the difficulty in predicting whether metabolism will result in detoxication or activation, the different metabolic roles of tissue cytochromes P-450, and the significance of oxygen radical formation, are reviewed. A number of specific chemical problems are discussed, including the safety evaluation of benzene, methylene dichloride, DDT, dieldrin, TCDD, the PCBs, and the hepatotoxic drugs: benoxaprofen and tienilic acid. Two novel methods for the prospective evaluation of chemical toxicity are described, namely (i) computer optimized parametric analysis for chemical toxicity (COMPACT) based on the computer graphic determination of chemical structure and its relationship to specific cytochromes P-450 and hence toxicity, and (ii) enzyme activation in chemical toxicity (ENACT) based on the induction of specific cytochromes P-450 by the chemical, from which toxicity can be predicted.. ...
Chrysalis Pharma Consulting, LLC. James S. MacDonald is founder and president of Chrysalis Pharma Consulting, a firm focused on bringing new molecular entities from the lead optimization stage to proof-of-concept in patients. He is also a founding partner of Synergy Partners R&D Solutions, LLC, which partners with small and medium sized pharmaceutical companies to enable rapid movement of new concepts for breakthrough therapies into human clinical testing, proof-of-concept and partnering to support further development. Over a period of 31 years before founding these companies, he held several leadership positions at Merck and Schering-Plough, retiring as executive vice president of preclinical development. In the latter role, he oversaw the company?s Department of Drug Safety and Department of Drug Metabolism/Pharmacokinetics and led efforts to move new molecular entities from discovery into clinical trials. Dr. MacDonald?s research interests lie in assessing strategies for identifying potential ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
According to Stratistics MRC, the Global In Vitro Toxicology Testing Market is accounted for $12.30 billion in 2015 and is expected to reach $32.45 billion...