This statistic shows the production volume of unsaturated polyester resins for fiber glass reinforced plastics in Japan from 2012 to 2019.
Human health: In vitro data were found in the Toxcast database of which 49 assays relate to EATS endpoints. For estrogen activity 23 results are available, for androgen activity 9, for thyroid activity 15 and for steroidogenesis 2. All assays were negative when including those where cytotoxicity was exceeding the activity concentration (7 assays). Beside cytotoxicity, 5 assays showed additional flags on which basis the active result was concluded to be negative as well. Several in vivo repeated dose and reproductive toxicity assays are available: 28-and 90-day studies (OECD TG 407 and 408); 38 to 60-days repeated dose toxicity information from the dose range finder (DRF, eq to OECD TG 421) for the Extended One Generation Reproductive Toxicity test (EOGRT, OECD TG 443), the EOGRT study itself and the developmental toxicity studies (OECD TG 414). On fertility there are the DRF for the EOGRT and the main EOGRT itself. For developmental toxicity, studies in rat and rabbit are available. In all these ...
Partly cited from SIAR for SIAM 23 (Jeju, Korea, October 17-20, 2006): Studies in Animals No studies have been performed to explicitly address the question of reproductive effects in animals caused by 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate. However, relevant information can be found in studies on different endpoints. Histopathological results of a subacute 28-day inhalation study in rats according to OECD TG 412 (adjusted to fulfill both the TSCA § 798.2250 as well as EU Guideline 92/69/EEC) showed no effects on the reproductive organs (ovaries, oviducts and testes) at tested concentrations of up to 4.1 mg/m3. Testes and ovary weights were also not affected. The NOAEC for general toxicity is 0.24 mg/m3. For further details on general toxicity see chapter 7.5.3 (Bayer AG, 2003). Based on the results there are no indications for specific adverse effects on the reproductive organs following 28-day treatment with up to 4.1 mg/m3despite the fact that already at 1.05 mg/m3the ...
Under section 8 in the Annexes of the information, required Toxicological Information is outlined. In section 8.4, Mutagenicity testing assays are listed, which call for a tiered approach to toxicological assessment of substances. Further, under section 8.5 and 8.6 Acute Toxicity and Repeated Dose Toxicity assays are noted. Although the approach and procedures for testing are outlined, the interpretation of results and navigation of testing options requires expertise and experience. BioReliance has assembled the foremost collection of scientists available anywhere and thus you can rely on us to assist in your REACH testing needs ...
PMIScience.com is operated by Philip Morris International for the purpose of publishing and disseminating scientific information about Philip Morris Internationals efforts to develop and assess products that have the potential to reduce individual risk and population harm associated with tobacco use. This site is for use by scientists, the public health and regulatory communities, and other stakeholders with an interest in tobacco policy. The purpose of this site is not for advertising or marketing. It is not intended for use by consumers ...
Read chapter 9 Effects of Jet-Propulsion Fuel 8 on Reproduction and Development: This report provides a critical review of toxicologic, epidemiologic, an...
Development of a rapid, sensitive and cost-effective method for toxicity assessment of commonly used nanoparticles is urgently needed for the sustainable development of nanotechnology. A neural cell with high sensitivity and conductivity has become a potential candidate for a cell chip to investigate toxicity of environmental influences. A neural cell immobilized on a conductive surface has become a potential tool for the assessment of nanotoxicity based on electrochemical methods. The effective electrochemical monitoring largely depends on the adequate attachment of a neural cell on the chip surfaces. Recently, establishment of integrin receptor specific ligand molecules arginine-glycine-aspartic acid (RGD) or its several modifications RGD-Multi Armed Peptide terminated with cysteine (RGD-MAP-C), C(RGD)4 ensure farm attachment of neural cell on the electrode surfaces either in their two dimensional (dot) or three dimensional (rod or pillar) like nano-scale arrangement. A three dimensional RGD modified
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
A disk-shaped thin plate or a long-sized thin plate having a roll appearance housed in a casing in which openings for penetration of test substance are formed and on which diffusion-limiting membranes are adhered to cover each openings. Also a driving mechanism for moving the thin plate is provided with the casing. The casing thus houses the thin plate and is provided with the driving mechanism and is positioned in a test apparatus body having a concentration measuring electrode therein. Multiple measurments of concentration of a test substance are carried out by moving the thin plate by the driving mechanism to position the diffusion-limiting membrane having the test solution deposited thereon to the position available to contact with the concentration measuring electrode, while keeping the casing placed in the test apparatus body. As a result, a plurality of measurements of concentration of the test substance is carried out easily.
I have been working with a team of EPA colleagues to create an on-line tool, Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), that will help both researchers and regulators readily use available protein sequence and structural knowledge to extrapolate chemical toxicity information across species. When complete, this innovative research tool will help predict potential chemical susceptibility to wildlife, including plants and animals.. Through the years, scientists have come to understand that the sensitivity of a species to a chemical is determined by a number of factors including chemical exposure, absorption, distribution, metabolism, elimination, and the organisms life-history. Additionally, an important consideration for species susceptibility is the presence or absence of proteins that interact with chemicals. Those that interact can be referred to as protein targets. Researchers take advantage of such protein targets to develop or improve drugs and/or pesticides, ...
Currently, products made with nanomaterials are used widely, especially in biology, bio-technologies, and medical areas. different NPs), and each of the NPs were characterized by numerous techniques, for example, zeta potentials, scanning electron microscopy, and transmission electron microscopy. Evaluation of the no observed adverse effect level and systemic toxicities of all NPs were performed by thorough evaluation steps and the toxicokinetics step, which included in vivo studies with zinc oxide and silica NPs. A peer review committee was structured to evaluate and verify the reliability of toxicity checks, and the risk communication step was also needed to convey the current findings to academia, industry, and consumers. Several limitations were experienced in the RT-NASA project, and they are discussed for thought for improvements in future studies. Keywords: nanomaterials, nanotoxicity, toxicokinetics, physicochemical house, peer review Intro Nanoparticles (NPs) refer to compounds or ...
As science progresses, new methods are developed to accomplish tasks. Some help medical and agricultural science work faster, others allow completely news ways of doing things. In the business of promoting new crop traits, CRISPR is one example of a revolutionary new technology that opens up new avenues. But it isnt the only one. In […]. ...
Description. The goal of 3.044 is to teach cost-effective and sustainable production of solid material with a desired geometry, structure or distribution of structures, and production volume. Toward this end, it is organized around different types of phase transformations which determine the structure in various processes for making materials, in roughly increasing order of entropy change during those transformations: solid heat treatment, liquid-solid processing, fluid behavior, deformation processing, and vapor-solid processing. The course ends with several lectures that place the subject in the context of society at large. The goal of 3.044 is to teach cost-effective and sustainable production of solid material with a desired geometry, structure or distribution of structures, and production volume. Toward this end, it is organized around different types of phase transformations which determine the structure in various processes for making materials, in roughly increasing order of entropy ...
Volume weighed percent positive (VWPP) - The VWPP for a specific product-pathogen pair is calculated by combining the production volumes (production volume can be defined as the amount (weight or numbers of head) of product produced per year) for establishments with their sampling results. This provides a more accurate estimation than a percent positive, but the data do not meet the statistical requirements to make a prevalence estimate. VWPP is more public health focused than PP, in that weighting results by volume reflects exposure of the public to specific pathogens ...
BMWs new era of sports cars will commence in June when the $135,700 BMW i8 plug-in hybrid goes on sale.. The launch date was announced with minimal fanfare on the BMW USA website, and while examples of the 362hp carbon fiber car will touch down in BMW dealerships, they wont stay for long as every one is allegedly already spoken for.. Production volumes will be modest for 2014, wi More. BMWs new era of sports cars will commence in June when the $135,700 BMW i8 plug-in hybrid goes on sale.. The launch date was announced with minimal fanfare on the BMW USA website, and while examples of the 362hp carbon fiber car will touch down in BMW dealerships, they wont stay for long as every one is allegedly already spoken for.. Production volumes will be modest for 2014, wi More. […]. ...
The objectives of the Human Health Exposure Assessment include 1 estimate the type and magnitude of exposures to contaminants 2 Identify contaminants of concern 3 Identify sites for remedial action 4 Recommend sites for the no action remedial alternative and 5 Provide a basis for detailed characterization of the risk associated with all sites. This document consists of the following An executive summary. Vol I - Land use and exposed population evaluations. Vol. II III - Toxicity assessment includes army and shell toxicity profiles. Vol. IV - PPLV Methodology. Vol. V - PPLV calculations. Vol. VI - Study area exposure analysis a introduction, B Western study ares, C Southern study area, D northern Central study area, E Central study area, F Eastern study area, G South plants study area, and H North plants study area. Vol. VII - Summary exposure assessment. Vol. VIII.
ACToR was developed to support the ToxCast program of the EPA National Center for Computational Toxicology (NCCT). ToxCast develops faster methods to evaluate the potential toxicity for thousands of chemicals using computer modeling and advanced molecular biology techniques. ACToR was used to analyze toxicity information on almost 10,000 chemicals regulated by EPA and to identify data gaps to be addressed by ToxCast, which will greatly help EPA prioritize future testing of chemicals. Key findings are that while acute toxicity data is available for 59 percent of the surveyed chemicals, detailed testing information is much more limited. Twenty-six percent of the 10,000 chemicals have carcinogenicity testing data, 29 percent have developmental toxicity testing data, and 11 percent have complete reproductive toxicity test results ...
... BEIJING April 18 /- BioDuro & The National Center fo...Dean Rodwell BioDuros Vice-President of Toxicology stated Although...Dr. Li Bo from the National Institute for the Control of Pharmaceutica...The Centers main tasks are to carry out the toxicological tests andp...,BioDuro,&,The,National,Center,for,Safety,Evaluation,of,Drugs,Received,Full,AAALAC,Accreditation,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Washington, D.C. - Riding the wave of the future, EPAs ToxCastTM program looks to revolutionize the agencys chemical toxicity evaluation procedures.  ...
The aim of this Challenge was to develop and characterise non-mammalian assays to provide an indication of developmental and reproductive toxicity potential to mammals, including man, in order to reduce and refine in vivo mammalian testing. To address this Challenge, the team at the Institute for Risk Assessment Sciences/ Toxicology, led by Professor Raymond Pieters, have formed a company called Vivaltes that offers a service pipeline for toxicological assessments using non-mammalian species.
Newcells Biotech Ltd has developed an in vitro model of the retinal pigmented epithelium, to assess the safety and efficacy of novel ocular compounds. This technology could better predict the outcome in the human eye and reduce the number of animals used to assess the toxicity of ocular drugs. An end-user pharmaceutical company, able to provide access to ocular compounds and data with known in vivo/in vitro toxicity profiles, is sought to validate the model.
How to use a panel of response element vectors targeting the key pathways involved in the cellular stress response. These vectors can be incorporated into diverse cell model systems to predict specific target site toxicities and create chemical stress signatures for specific classes of compounds.
The medieval physician Paracelsus said: Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy. Often quoted in paraphrase as the dose makes the poison, this truism has dominated
The therapy has already produced encouraging results in pre-clinical studies and regulatory toxicology tests in preparation for first-in-human clinical trials. - News - PharmaTimes
Driven by wide recognition that target tissue (or cell) dose is the most appropriate metric of dose for risk and safety assessment, there has been continued growth in the development of computational tools for estimating target tissue dose in vivo for a wide range of materials: volatile and non-volatile materials [42-44] organic chemicals [45, 46], pharmaceuticals [47, 48], and particulates and ultrafine particulates [49-53]. It is surprising, then, given the growing importance of in vitro studies to chemical and particle risk assessment [10] that few efforts [43, 54-56] have been directed at developing computational models of dosimetry for in vitro systems. In part, this oversight may be the result of the incorrect belief that in contrast to in vivo, there are no important kinetic or other processes to consider when addressing the issue of target tissue dose in vitro. We have shown this assumption is not universally true for chemicals [54] and particulates, including nanomaterials [12]. Thus, ...
Injection molding is best suited for large production volumes. It is a high investment cost with a complex processing method, typically producing excess scrap.
trina allmax 255w Trina ALLMAX 255W Solar Module, model TSM-PD05.05, provides exceptional value for residential grid-tie & off-grid projects. One of the most versatile solar modules available, and in a power range & size that makes it easy to build systems with all the popular BOS components. Trina is also one of the top-ranked manufacturers in terms of both production volume, price, and ethics.
Our world-leading experts in fire chemistry, toxicity, and human behaviour are at the forefront of the development of National and International standards in the field ...
Scientists are now closer to having the ability to determine what a safe dose of nanomaterials is to humans, thanks to a comprehensive study completed at PNNL.
A probabilistic ecological hazard assessment technique, chemical toxicity distributions, was used to examine the relative sensitivities of in vitro and in vivo assays for detecting estrogenicity, and to assess the hazards ...
Toxicological Principles for the Safety Assessment of Food Ingredients - Chapter IV.C.3.a. Short-Term Toxicity Studies with Rodents
Clinical trial for Coronary Artery Lesions , XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR Patients.
Desenvolvimento folicular in vitro Efeito de fatores de crescimento (NGF e FGF-10) e hormônio insulina no cultivo in vitro de folículos ovarianos caprinos. Állatgyógyszerészet Novas Edições Acadêmicas (09.02.2015) - ISBN-13: 978-3-639-74377-7 ...
Powered by Permasure® ; Simple to use toxicity modeller app offering instant safe-use times accounting for temperature and chemical toxicity for over 4000…
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Toxicity Identification (TI)/Reduction Evaluations (RE) Service by AquaTox Testing & Consulting Inc.. AquaTox uses the Toxicity Reduction Evaluation (TRE) ...
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All about Principles for the Toxicological Assessment of Pesticide Residues in Food: Environmental Health Criteria Series 104 by ILO. LibraryThing is a cataloging and social networking site for booklovers
This paper aimed to evaluate the test results of acute toxicity on effluent samples which were exempted from applying of ecotoxicity criteria. Total 316 effluent samples which were free from controlling of ecotoxicity regulation, were tested. Ratio of effluent samples which were exceeded the ecotoxicity criteria (TU > 1) indicated 23.7%. This ratio was a little bit higher than previous study (22.7%) on effluent samples which were controlled under ecotoxicity criteria. These results mean that our ecotoxicity management system is not appropriate and applying of ecotoxicity criteria to all effluent samples (82 industry categories) were needed in order to improve our ecotoxicity system. In addition, the same numeric criteria (TU 1 or 2) for all industry categories were proposed in consideration of these results. Ratio of effluent samples which exceeded the ecotoxicity criteria (TU > 1) with D. magna indicated 23.7%. However V. fischeri showed 14.6%. As a acute toxicity test organism, D. magna seemed ...
The regulatory evaluation of ecotoxicity studies for environmental risk and/or hazard assessment of chemicals is often performed using the method established by Klimisch and colleagues in 1997. The method was, at that time, an important step toward improved evaluation of study reliability, but lately it has been criticized for lack of detail and guidance, and for not ensuring sufficient consistency among risk assessors. A new evaluation method was thus developed: Criteria for Reporting and Evaluating ecotoxicity Data (CRED). The CRED evaluation method aims at strengthening consistency and transparency of hazard and risk assessment of chemicals by providing criteria and guidance for reliability and relevance evaluation of aquatic ecotoxicity studies. A two-phased ring test was conducted to compare and characterize the differences between the CRED and Klimisch evaluation methods. A total of 75 risk assessors from 12 countries participated. Results show that the CRED evaluation method provides a more
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test - four week repeated toxicity test;gami jakyak gamcho buja decoction (mecasin);herbal medicine;sprague-dawley rat;
A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test;kpubs;kpubs.org
While direct toxicity assessment (DTA) is now widely recognised as a useful tool for environmental risk assessment, many existing tests fail to meet end-user needs. This article describes the significant progress made to the MICREDOX® DTA assay, developed at Lincoln Ventures Ltd, brought about by miniaturising this assay to a multi-well plate format combined with limiting current microelectrode transduction. The benefits have been reduced: preparation time, reduced assay time, lower material costs and a higher level of replication achieved. To validate the precision of the miniaturised format, the concentrations required to cause a 50% decrease in signal (EC50) by an archetypal group of toxicants, the chlorophenols, were determined using two terrestrial bacterial strains, Escherichia coli K12 and Klebsiella oxytoca 13183. The assay time was then reduced by stepwise adjustment of the incubation time, from 60 down to 5 min, and the EC50s reported by E. coli to each of the toxicants after 45, 30, ...
The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimized wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments has been banned; in other situations, the number of organisms tested has been dramatically reduced or the severity of the procedure refined. However, there is still a long way to go to achieve a complete replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is based not just on ethical considerations but also on reducing the cost of performing vertebrate ecotoxicity tests and in some cases on providing better information aimed at improving environmental risk assessments. The present Focus article provides an overview of the ...
Neurodegenerative properties of acrylamide were studied in vitro by exposure of differentiated SH-SY5Y human neuroblastoma cells for 72 h. The number of neurites per cell and the total cellular protein content were determined every 24 h throughout the exposure and the subsequent 96-h recovery period. Using kinetic data on the metabolism of acrylamide in rat, a biokinetic model was constructed in which the in vitro toxicity data were integrated. Using this model, we estimated the acute and subchronic toxicity of acrylamide for the rat in vivo. These estimations were compared to experimentally derived lowest observed effect doses (LOEDs) for daily intraperitoneal exposure (1, 10, 30, and 90 days) to acrylamide. The estimated LOEDs differed maximally twofold from the experimental LOEDs, and the nonlinear response to acrylamide exposure over time was simulated correctly. It is concluded that the integration of the present in vitro toxicity data with kinetic data gives adequate estimates of acute and ...
According to „Guidance on information requirements and chemical safety assessment Part B: Hazard assessment derivation of DNELs is not necessary if no adverse effects have been observed in studies at the highest recommended concentrations/doses tested. In all available acute toxicity tests Acetoguanamine is reported to cause no adverse effects at the highest recommended dose. Therefore no acute DNELs could be derived. No data from repeated dose toxicity studies, reproductive studies (including developmental toxicity) and carcinogenity studies are available for Acetoguanamine. These studies are necessary to evaluate possible long term effects and derive long term DNELs on the basis of a reliable dose descriptor N(L)OAEL, benchmark dose etc. Because of this reason the registrant will derive long term DNELs for Acetoguanamine in case that adverse effects should appear in the proposed repeated dose studies. ...
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Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studie
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ASTM E724 : Standard Guide for Conducting Static Acute Toxicity Tests Starting with Embryos of Four Species of Saltwater Bivalve Molluscs
The Rio Grande River is the natural boundary between U.S. and Mexico from El Paso, TX to Brownsville, TX. and is one of the major water resources of the area. Agriculture, farming, maquiladora industry, domestic activities, as well as differences in disposal regulations and enforcement increase the contamination potential of water supplies along the border region. Therefore, continuous and accurate assessment of the quality of water supplies is of paramount importance. The objectives of this study were to monitor water quality of the Rio Grande and to determine if any correlations exist between fecal coliforms, E. coli, chemical toxicity as determined by Botsfords assay, H. pylori presence, and environmental parameters. Seven sites along a 112-Km segment of the Rio Grande from Sunland Park, NM to Fort Hancock, TX were sampled on a monthly basis between January 2000 and December 2002. The results showed great variability in the number of fecal coliforms, and E. coli on a month-to-month basis. Fecal
1. Relevant Toxicology Data, exposure pattern and route The calculation of the DNEL is based on the results of a 28 day repeated dose toxicity study in rats (OECD 407). The oral administration of the test material resulted in microscopic changes in the mid- and high-dose groups in the adrenals, kidneys, and stomach/forestomach. The effects on the adrenals were accompanied by an increased organ weight. The FOB (functional observational battery) identified decreased landing foot splay in the mid- and high-dose females, and also decreased rectal temperature in the high-dose females. A NOAEL for systemic toxicity was established at 150 mg/kg bw. 2. Mode of action No non-threshold mode of action is associated with this substance, in particular, the test substance has no genotoxic potential. 3. Correction of dose descriptor NOAEL (oral) is converted into a NOAEL(corrected) in accordance to Guidance on information requirements and chemical safety assessment, Chapter R.8: Characterization of dose ...
Daqo New Energy provides non-GAAP gross profit, non-GAAP gross margin, EBITDA and EBITDA margin on a non-GAAP basis to provide supplemental information regarding its operating performance. For more information on these non-GAAP financial measures, please see the section captioned Non-GAAP Financial Measures and the tables captioned Reconciliation of non-GAAP financial measures to comparable US GAAP measures set forth at the end of this press release.. ** Production cost and cash cost only refer to production in our Xinjiang polysilicon facilities. Production cost is calculated by the inventoriable costs relating to production of polysilicon in Xinjiang divided by the production volume in the quarter. Cash cost is calculated by the inventoriable costs relating to production of polysilicon excluding depreciation expense of Xinjiang divided by the production volume in the quarter.. We are proud that the Company continues to deliver excellent performances in the second quarter of 2014 and ...
The Brazilian sugar and alcohol sector will grind a record-breaking volume of sugarcane this year according to results of a second national crop survey, released last week by Conab. The results show that the total harvest is expected to reach 629.02 million tons, a 10% increase over 2008. The growth is a result of better distribution of rainfall and expanded planted area, which reached 7.74 million hectares.
Video created by University of Illinois at Urbana-Champaign for the course Managerial Accounting: Tools for Facilitating and Guiding Business Decisions. After establishing goals, setting targets, and the budget, upper management uses variance ...
A reliable oral Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test withN-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate (CAS 25646-71-3) is available and was performed according to OECD 422 (van Otterdijk, 2018) and in compliance with GLP. Groups of 10 male and 10 female Wistar rats were exposed to the test substance at dose levels of 5, 15 and 50 mg/kg bw/day by oral gavage once daily for 7 days/week. Males were treated for 2 weeks prior to mating, during mating, and up to termination (for 29 days). Females that delivered offspring were treated for 2 weeks prior to mating, during mating, during gestation, and at least 13-15 days of lactation (for 50-56 days). One female, which failed to deliver, was treated for 41 days. Control animals (10 per sex and dose) received the concurrent vehicle, water, only. Dose levels in this study were based on the results of a dose range finding study. In this range finding study, rats ...
Aquatic toxicity tests were originally designed for individual compounds that are soluble and stable in water. For sparingly soluble substances that are not toxic at the solubility limit, the issue is whether tests should be performed with insoluble test substance present. Based on a literature evaluation of the physiology of uptake, it was concluded that only the dissolved fraction is available for uptake and that the insoluble test substance may introduce artifacts that aggravate data interpretation. Therefore, toxicity tests should be conducted only up to the solubility limit. Testing of volatile, unstable, or adsorptive substances is complicated by the ability to keep exposure concentrations relatively constant. For these, appropriate test protocols including adequate design of the dosing systems must be employed. For test medium preparation, physical methods and, where necessary, use of low concentrations of certain solvents are recommended to support handling and speed of dissolution. ...
Plasma samples (5animals/sex/group) were collected from 100, 200 and 2000 ppm diphenyl sulphone dosed treatment groups, including control groups, after 1 and 12 weeks of treatment (this study was part of the 90 -day toxicity study in rats; ICI, 1981). These samples were then stored at -20° C whilst a reverse phase HPLC method was developed and validated . Pooled samples were then analysed for test article using this analytical procedure. The plasma diphenyl sulphone levels of treated animals showed a positive but non-linear correlation with dose. Circulating levels of diphenyl sulphone were comparable at the week 1 and 12 investigations for the 100 and 200 ppm dosed group. However, during week 12 group 2000 ppm dosed males showed a fall in plasma level when compared to week 1, whilst the plasma diphenyl sulphone level of 2000 ppm dosed females rose against the week 1 value. Consequently, on this occasion the plasma concentration shown by females was some four times higher than that of the ...
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellular hypertrophy, cell proliferation, and, frequently in long-term (life-time) studies, hepatocarcinogenesis.
An anterolateral view (left side) of the blood supply of the male reproductive organs and lower limbs relative to the skeleton. The surface anatomy of the body is semi-transparent and tinted red. - Stock Image F002/2443
An anterior view of the blood supply of the male reproductive organs and lower limbs relative to the skeleton. The surface anatomy of the body is semi-transparent and tinted turquoise. - Stock Image F002/2809
The Tox21 partner agencies work together to develop, validate, and translate innovative in vitro HTS methods to characterize the impact of chemicals on key steps in toxicity pathways.. Data collected in the Tox21 initiative has been used to prioritize uncharacterized compounds for regulatory testing using both traditional and novel test methods. To more broadly address challenges in the field of toxicology, in 2018 Tox21 released a new strategic and operational plan (Thomas et al. 2018) that expands the focus of its research activities. New focus areas include expanding its portfolio of alternative test systems, addressing technical limitations of in vitro test systems, curating legacy in vivo toxicity testing data, establishing scientific confidence in in vitro test systems, and refining alternative methods for characterizing pharmacokinetics and in vitro assay disposition. The eventual goal of Tox21 is to use HTS methods to generate data that will allow risk assessors to more accurately ...
The resource Dermal Absorption and Toxicity evaluation provides a state of the art evaluation of the dermal absorption method, and is split into six good equipped sections. Written by way of across the world famous specialists within the box, this moment variation is an entire revised and up-to-date textual content, overlaying the big variety of equipment used to evaluate pores and skin absorption and some of the governmental and business courses fascinated by pores and skin permeation and toxicity. those contain replacement in silico, in vitro, and in vivo ideas to behavior reports for regulatory standards. To make room for this new elevated content material, the editors are publishing a concurrent textual content entitled: Dermatological and beauty improvement with a focus on matters serious about dermatological and beauty ...
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Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3-Azido-3-deoxythymidine (AZT) and Rifabutin Combinations (CASRNs 30516-87-1 and 72559-06-9) Administered by Gavage to Swiss (CD-1®) ...
Regulatory Toxicology and Pharmacology. 2014;68:275-296. Thousands of man-made chemicals in use today may enter the food chain. Some of these may result in human exposure, while no toxicological data may be available. The present manuscript illustrates a decision tree for risk assessors and managers to establish fast and reliable safety levels of concern associated with dietary exposures.. Thousands of man-made chemicals are in use today. Many of these compounds may enter the food chain and result in human exposure. Since toxicological information is limited or lacking for the vast majority of these chemicals, the assessment of their health significance is therefore difficult, but envisaged.. A decision tree has been developed taking into account practical application of in silico methods. Basic concepts of classical risk assessment have been integrated: 1) exposure assessment 2) hazard identification 3) hazard characterization and 4) risk characterization.. The present work indicates that if ...
This case study summarizes events relating to the death of a man with seizure disorder who, after evaluation by the county coroner, was evaluated for pesticide exposure via toxicological assessment.