We present the case of a 10-year-old boy, Sam, with congenital deafness and Gilles de la Tourette Syndrome (GTS). GTS is characterised by multiple motor t
Causes and origins of Tourette syndrome have not been fully elucidated. Tourette syndrome (also called "Tourettes syndrome", "Tourettes disorder", "Gilles de la Tourette syndrome", "GTS" or "TS") is an inherited neurological disorder with onset in childhood, characterized by the presence of multiple motor tics and at least one phonic tic, which characteristically wax and wane. Tourettes syndrome occurs along a spectrum of tic disorders, which includes transient tics and chronic tics. The exact cause of Tourettes is unknown, but it is well established that both genetic and environmental factors are involved. Genetic studies have proved that the overwhelming majority of cases of Tourettes are inherited, although the exact mode of inheritance is not yet known, and no gene has been identified. Tics are believed to result from dysfunction in the thalamus, basal ganglia, and frontal cortex of the brain, involving abnormal activity of the brain chemical, or neurotransmitter, dopamine. Other ...
TY - JOUR. T1 - The relationship between group A streptococcal infections and Tourette syndrome. T2 - A study on a large service-based cohort. AU - Martino, Davide. AU - Chiarotti, Flavia. AU - Buttiglione, Maura. AU - Cardona, Francesco. AU - Creti, Roberta. AU - Nardocci, Nardo. AU - Orefici, Graziella. AU - Veneselli, Edvige. AU - Rizzo, Renata. PY - 2011/10. Y1 - 2011/10. N2 - Aim To evaluate the relationship between diagnosis and clinical course of Tourette syndrome and group A Streptococcus (GAS). Method GAS infections, anti-streptococcal, and anti-basal ganglia antibodies (ABGA) were compared between 168 patients (136 males, 32 females) with Tourette syndrome; (median [range] age [25th-75th centile] 10y [8-11y]); median Tourette syndrome duration (25th-75th centile), 3y (1y 3mo-5y 9mo) and a comparison group of 177 patients (117 males, 60 females) with epileptic or sleep disorders median age [25th-75th centile], 10y [8y-1y 6mo]). One hundred and forty-four patients with Tourette syndrome ...
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.
Tourette syndrome - also called Tourettes syndrome, Tourette Spectrum (TS), Tourettes disorder, or Gilles de la Tourette syndrome, is a neurological or neurochemical disorder characterized by tics: involuntary, rapid, sudden movements or vocalizations that occur repeatedly in the same way.
This year, for the 2012 Disneyland Half Marathon, the Tourette Syndrome Assosiation (TSA) is thrilled to field an official team in theDisneyland Half Marathon Weekend on August 31 - September 2! Any support you can give our TSA Half Marathoners by sponsoring their valiant 13.1 mile run on behalf of the work of the Tourette Syndrome Association is greatly appreciated. Meet our runners below and back your favorite one or you can contribute to the whole team just by clicking the Donate button thats on the right. The money we raise is used to identify the cause of, find the cure for and controle the effects of Tourette Syndrome. We offer resources and referrals to help people and their families cope with the problems that occur with TS. We raise public awareness and counter media stereotypes about TS. Our membership includes individuals, families, relatives, and medical and allied professional working in the field. To learn more about the Tourette Syndrome Association, visit the website by
Researchers have conducted the first genome-wide search to look for any genes responsible for Tourette syndrome and obsessive-compulsive disorder (OCD). Findings show that neither OCD nor Tourette syndrome are simple enough to be traced to a single problem gene, but the researchers have been able to pinpoint several
Tourette syndrome is a neurological disorder that is characterized by repetitive, involuntary movements and vocalizations called tics. Many children with Tourette syndrome also have attention deficit hyperactivity disorder (ADHD), which is one of the most common childhood mental disorders. Symptoms of ADHD usually include impulsiveness, inattention, and hyperactivity. ADHD is commonly treated with a stimulant medication, such as methylphenidate. It is under debate, however, whether using stimulants in children with Tourette syndrome exacerbates tics associated with the disorder. This study will evaluate the safety and effectiveness of methylphenidate in treating ADHD in children who have both ADHD and Tourette syndrome.. Participants in this 6-week, double blind study will receive three doses of methylphenidate over the course of the study. Each dose will be taken twice daily, approximately 3.5 hours apart, for 2 weeks. Medication will be dispensed at study visits, which will occur once every 2 ...
Tourette Syndrome Therapeutics - Pipeline Assessment and Market Forecasts to 2019 report is an essential source of information and analysis on the global Tourette Syndrome Therapeutics market. The report identifies the key trends shaping and driving the global Tourette Syndrome Therapeutics market. The report also provides insights on the prevalent competitive landscape and the emerging players expected to significantly alter the market positioning of the current market leaders. Most importantly, the report provides valuable insights on the pipeline products in the global Tourette Syndrome Therapeutics sector ...
Anti-basal ganglia antibodies (ABGAs) have been suggested to be a hallmark of autoimmunity in Gilles de la Tourettes syndrome (GTS), possibly related to prior exposure to streptococcal infection. In order to detect whether the presence of ABGAs was associated with subtle structural changes in GTS, whole-brain analysis using independent sets of T1 and diffusion tensor imaging MRI-based methods were performed on 22 adults with GTS with (n = 9) and without (n = 13) detectable ABGAs in the serum. Voxel-based morphometry analysis failed to detect any significant difference in grey matter density between ABGA-positive and ABGA-negative groups in caudate nuclei, putamina, thalami and frontal lobes. These results suggest that ABGA synthesis is not related to structural changes in grey and white matter (detectable with these methods) within frontostriatal circuits. ...
TY - JOUR. T1 - Double-Blind, Crossover Study of Clonidine and Levetiracetam in Tourette Syndrome. AU - Hedderick, Erika F.. AU - Morris, Christina M.. AU - Singer, Harvey S.. PY - 2009/6/1. Y1 - 2009/6/1. N2 - We compared the efficacy of clonidine and levetiracetam for treating tics in Tourette syndrome. Twelve subjects were enrolled; 10 (ages 8-27 years) with moderate to moderately severe tics completed a 15-week randomized, double-blind, flexible-dose crossover protocol. Initial medication doses were clonidine (0.05 mg, twice daily) or levetiracetam (10 mg/kg/day, divided twice daily). Doses were adjusted weekly, based on telephone assessment. The primary outcome measure was baseline-to-posttreatment (6-week) change in Total Tic Score of the Yale Global Tic Severity Scale. Secondary outcome measures included total Yale Global Tic Severity Scale and Clinical Global Impression scores and behavioral measures. The mean Total Tic Score improved significantly from baseline to posttreatment with ...
OBJECTIVES: I. Investigate the pathobiology of Tourette syndrome and related disorders by measuring various compounds of interest in cerebrospinal fluid, plasma, and urine of patients with Tourette syndrome, obsessive compulsive disorder, and/or chronic tics.. II. Determine the pattern of familial aggregation of Tourette syndrome and obsessive compulsive disorder by systematic assessment of all first-degree family members of patients selected for cerebrospinal fluid studies.. III. Establish the neurochemical and neuropeptide profile associated with the range of expression of the putative Tourette gene expression in adult and adolescent patients. ...
Detailed info on Tourette syndrome aka Tourette disorder. Includes facts on Tourette syndrome symptoms, causes and treatment and Tourettes in children.
0033]There is also a strong association of obsessive compulsive disorder with movement disorders. Obsessive compulsive disorder is associated with Gilles de la Tourette syndrome (Tourette syndrome), as well as with several other basal ganglia diseases including Sydenhams chorea and Huntingtons disease. There is strong evidence of a link between obsessive compulsive disorder and motor tics. While estimates of the occurrence of obsessive compulsive disorder in patients with Tourette syndrome vary from 5% to over 50%, all estimates are significantly higher than the prevalence of obsessive compulsive disorder in the general population. Shared clinical features between obsessive compulsive disorder and Tourette syndrome include "waxing and waning of symptoms, early age at onset, ego-dystonic behavior (i.e., behavior contrary to an individuals conscious preferences), worsening with depression and anxiety, and their occurrence in the same families" (Robertson and Yakely, supra). Genetic studies ...
... (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The disorder is named for Dr. Georges Gilles de la Tourette, the pioneering French neurologist who in 1885 first described the condition in an 86-year-old French noblewoman. The early symptoms of TS are typically noticed first in childhood, with the average onset between the ages of 3 and 9 years. TS occurs in people from all ethnic groups; males are affected about three to four times more often than females. It is estimated that 200,000 Americans have the most severe form of TS, and as many as one in 100 exhibit milder and less complex symptoms such as chronic motor or vocal tics. Although TS can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst tic symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood. Only 6-14% of people with tourette syndrome
Brand name is Haldol. A butyropherone derivative with antipsychotic properties, used in treatment of acute and chronic psychosis, including schizophrenia and manic states, as well as in managing of aggressive and agitated behavior in patients with chronic brain syndrome and mental retardation and in the symptomatic control of Gilles de la Tourettes syndrome.
Tourette syndrome (TS) is a complex neuropsychiatric disorder of unknown etiology that is characterized by involuntary vocal tics. Severity of this condition varies widely among patients. Though there is no cure for Tourette syndrome, the condition often improves with age. Experts estimate that 100,000 Americans are afflicted with TS.. A review of the scientific literature reveals several case reports and a small number of clinical trials specific to the use of cannabinoids for the treatment of TS. One of the first appears in the American Journal of Psychiatry in 1999. Investigators at Germanys Medical School of Hanover, Department of Clinical Psychiatry and Psychotherapy, reported successful treatment of Tourette syndrome with a single dose of 10 mg of delta-9-THC in a 25-year-old male patient in an uncontrolled open clinical trial.[1] Investigators reported that the subjects total tic severity score fell from 41 to 7 within two hours following cannabinoid therapy, and that improvement was ...
Health, ...Tourette syndrome a neurological disorder characterized by tics like ...Now a multisite study led by a UCLA researcher has developed an effec...Lead study author John Piacentini a UCLA professor of psychiatry and ...Almost 53 percent of children receiving CBIT were rated as significant...,Behavior,therapy,effective,in,reducing,tics,in,children,with,Tourette,syndrome,,study,finds,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Tourette syndrome is found among all social, racial and ethnic groups and has been reported in all parts of the world;[2][22] it is three to four times more frequent among males than among females.[3] The tics of Tourette syndrome begin in childhood and tend to remit or subside with maturity; thus, a diagnosis may no longer be warranted for many adults, and observed prevalence rates are higher among children than adults.[27] As children pass through adolescence, about one-quarter become tic-free, almost one-half see their tics diminish to a minimal or mild level, and less than one-quarter have persistent tics. Only 5 to 14% of adults experience worse tics in adulthood than in childhood.[2][6] Up to 1% of the overall population experiences tic disorders, including chronic tics and transient tics of childhood.[56] Chronic tics affect 5% of children, and transient tics affect up to 20%.[79] Prevalence rates in special education populations are higher.[3] The reported prevalence of TS varies ...
Fishpond Australia, Coping with Tourette Syndrome: A Workbook to Help Kids with Tic Disorders by Sandra BuffolanoBuy . Books online: Coping with Tourette Syndrome: A Workbook to Help Kids with Tic Disorders, 2008, Fishpond.com.au
The Massachusetts General Hospital Tourette Syndrome Clinic is a specialized multidisciplinary clinic and regional referral center for adult and pediatric patients with Tourette syndrome and other tic disorders.
... , from Hot Topics in Evaluation, Treatment and Management of Tourette Syndrome and Co-occurring Conditions
... is a condition that causes tics -- movements or sounds that are repeated over and over. Learn more about Tourette syndrome in this article for kids.
Looking back 40 years at the Tourette Syndrome Association and how they failed to explore alternative therapy treatments for tics and Tourette syndrome.
Volunteer with Tourette Syndrome Association - MA Chapter. Find Tourette Syndrome Association - MA Chapter volunteering opportunities at VolunteerMatch!
Gilles de la Tourette Syndrome (GTS) is a developmental neuropsychiatric disorder characterised by the presence of chronic motor and phonic tics. Drugs currently used in the treatment of GTS either lack efficacy or are associated with intolerable side effects. There is some anecdotal and experimental evidence that cannabinoids may be effective in treating tics and compulsive behaviour in patients with GTS. There are currently no systematic Cochrane reviews of treatments used in GTS. There is one other Cochrane review being undertaken at present, on the use of fluoxetine for tics in GTS. ...
People with Tourettes syndrome has a gene. Emotional and physical health or external stress, may also contribute to the development of Tourettes syndrome.
A very large Danish epidemiological study of 7590 children will estimate the frequency of tics among children aged 10-12 years. The study will also examine different pre- and perinatal factors as possible contributors to the development of tics. Estimates of the prevalence of Tourette Syndrome (TS) vary greatly among different studies. The range has been reported to be anywhere from 1 to 19 per 1000 children. These large differences may be attributed to small sample sizes, different age distributions and variations in sampling and diagnostic assessment. The largest and best designed study so far identified 25 children with TS out of 4479 (6 per 1000). The present study will use an epidemiological robust design and address tics among 7590 children aged 10-12 years. It will therefore be the largest epidemiological study of tics to date. The basic causes of TS and related tic disorders are poorly understood. Genetic factors are implicated, but the inheritance is complex and not yet understood ...
This proposed research leverages a large clinical and genetic dataset of individuals and families with Tourette Syndrome (TS) to identify heritable symptom-based phenotypes and conduct quantitative genome-wide association studies (qGWAS) with the ultimate goal of identifying genetic variants that contribute to TS susceptibility. TS is a complex developmental neuropsychiatric disorder that affects 1/150 to 1/300 children world-wide. Although the core features of TS (the presence of motor and vocal tics) are fairly straightforward, TS is phenotypically diverse, with some individuals manifesting only mild tics with little to no functional impact and others manifesting moderate to severe tics with marked impairment. Individuals at all levels of tic severity and in all age groups may also experience a range of co-occurring conditions that lead to significant functional impairment, most commonly obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD), but also including ...
A 31-year-old Chinese man with intractable severe, lifelong Tourettes syndrome characterised by forceful self-injurious motor tics and socially embarrassing vocal tics was treated with bilateral deep brain stimulation. Electrodes were implanted into the thalamic targets at the centromedian-parafascicular complex according to Hasslers nomenclature. A dramatic reduction of tics resulted. At 18 months postoperatively, there was an 81% improvement in his total tics count and a 58% improvement in his Yale Global Tic Severity Scale. His modified Rush video scale decreased from 13 to 8 and visual analogue scale from 10 to 3. These data show that bilateral deep brain stimulation of the thalamus can have a favourable immediate effect on severe tics in a selected group of adult patients suffering from intractable Tourettes syndrome and postoperatively the beneficial effects persisted for at least 18 months ...
Tourette syndrome (TS) is a complex inherited disorder of unknown aetiology, characterized by multiple motor and vocal tics. Involvement of the central cannabinoid (CB1) system is suggested because of therapeutic effects of marijuana (Cannabis sativa L.) consumption and Delta(9)-tetrahydrocannabinol (-THC) treatment in TS patients. The central cannabinoid receptor (CNR1) gene encoding the CNR1 was considered as a candidate gene for TS and systematically screened by single-strand conformation polymorphism (SSCP) analysis and sequencing. Compared with the published CNR1 sequence, three single base substitutions were identified: 1326T A, 1359G A, 1419 + 1G C. The change at position 1359 is a common polymorphism (1359 G/A) without allelic association with TS. 1326T A was present in only one TS patient and is a silent mutation which does not change codon 442 (valine). 1419 + 1G C affects the first nucleotide immediately following the coding sequence. It was first detected in three ...
... (TD), sometimes called Tourette syndrome (TS), is a neurological disorder characterized by multiple repeated tics. Tics are abrupt, purposeless, and involuntary vocal sounds or muscular jerks.
Background Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes.. Methods We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS.. Results Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p,0.01). The differences in FA values were highest in the ...
If you suffer from Tourette Syndrome (TS), or any other chronic motor or vocal tic disorder, you know how difficult it can be to manage your symptoms. You may be taking medication or working with a medical doctor to control your tics.
By Dr. Kenneth Shore Tourette syndrome (TS) is a neurological disorder that is characterized by tics, which can take the form of uncontrollable rapid body movements (motor tics) or involuntary verbalizations (vocal tics). A child with TS typically exhibits both types of tics. This disorder can present classroom management concerns for the teacher and self-esteem and peer acceptance issues for the student.. The behaviors that you will see with TS will vary with each child. These may include rapid blinking of the eyes, jerking of the head or twitching of the mouth. In some cases the behaviors are more disruptive such as kicking, touching other people or jumping. Involuntary vocalizations might include repeated throat clearing, grunting, yelping or saying words or phrases repeatedly. On very rare occasions, the person with TS will use offensive language involuntarily (for example, obscenities).. The majority of individuals with TS have mild cases. Most students with this disorder will be able to ...
... (TS) is the neurological disorder characterized by stereotyped, repetitive, involuntary movements and vocalizations called tics, which could be a vocal tic (apparently uncontrollable sounds such as grunting, throat clearing or humming) or motor tic (apparently uncontrollable and sudden movements such as exaggerated blinking of the eyes). This is the forum for discussing anything related to this health condition
There is now clear evidence that cannabinoids are useful for the treatment of various medical conditions," including chronic neuropathy (nerve pain), multiple sclerosis, HIV/AIDS, Gilles de la Tourette syndrome, and other indications. Regarding the safety profile of cannabis and cannabinoids, investigators determined: "The most common side effects of cannabinoids are tiredness and dizziness (in more than ten percent of patients), psychological effects, and dry mouth. Tolerance to these side effects nearly always develops within a short time. Withdrawal symptoms are hardly ever a problem in the therapeutic setting." Authors did express concern that cannabis could pose additional health risks for adolescents and/or pregnant or breast-feeding women, as well as individuals diagnosed with Hepatitis C, severe cardiovascular disease, addictive disorders, or those vulnerable to certain psychiatric disorders, such as schizophrenia. Investigators acknowledged that cannabis dosing may adversely impact ...
Electric zaps can help rewire the brains of Tourette syndrome patients, effectively reducing their uncontrollable vocal and motor tics, a new study shows.
Tics and Tourettes: Prevention and Treatment. Theres a saying that genetics loads the gun, but the environment pulls the trigger. Whether or not you have a family history of Tourette syndrome or related tic disorders, there are several approaches you can take to prevent and treat symptoms.. Doctors often tell people with Tourettes that there is nothing they can do to besides reducing stress: "The tics wax and wane-they come and go on their own." Some even refer to the process as a "mystery." Families are apparently expected to just sit back and watch the ups and downs take place. This attitude makes about as much sense as telling people with allergies that their symptoms will "wax and wane," without explaining which allergens may affect a persons symptoms.. Of course, doctors would tell their patients why vocal and muscle tics wax and wane-if they knew. But there has been an appalling lack of interest in the role of the environment by leaders in the field. In fact, for the last 18 years, our ...
Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options
Background: Tourette Syndrome (TS) is a neuropsychiatric disorder in children characterized by motor and verbal tics. Although several genes have been suggested in the etiology of TS, the genetic mechanisms remain poorly understood. Methods: Using cytogenetics and FISH analysis, we identified an apparently balanced t(6,22)(q16.2;p13) in a male patient with TS and obsessive-compulsive disorder (OCD). In order to map the breakpoints and to identify additional submicroscopic rearrangements, we performed whole genome mate-pair sequencing and CGH-array analysis on DNA from the proband. Results: Sequence and CGH array analysis revealed a 400 kb deletion located 1.3 Mb telomeric of the chromosome 6q breakpoint, which has not been reported in controls. The deletion affects three genes (GPR63, NDUFA4 and KLHL32) and overlaps a region previously found deleted in a girl with autistic features and speech delay. The probands mother, also a carrier of the translocation, was diagnosed with OCD and shares the ...
We see Gusti spend her own income, awkwardly board an escalator, talk on a mobile phone, visit her family, and hold hands with one of her new friends, who do not flee from her condition fearing that she might be contagious or dangerous.. Although Gusti, herself, and her new circle of friends must get much of the credit for her new prognosis, Lemelson himself and the video project about Gusti also appear to play important roles. First, in the meetings with the research team, we see both Lemelson and an Indonesian psychiatrist trying to explain Tourette Syndrome to the family, who were at first so baffled by Gustis behaviour.. Then, Lemelson introduces Gusti to Dayu, another woman with Tourettes, but also with a university degree, a job, and a devoted husband, in addition. Dayus tics are more pronounced than Gustis; even when she is not under stress, Dayu cannot control the expressions that seemingly ripple across and stretch her face constantly. Dayu and Gusti talk in the video and, though ...
Except for the controversy regarding the potential role of group A beta-haemolytic streptococcal (GABHS) infections in a subset of patients with Tourette syndrome or obsessive-compulsive disorder,4 less attention has been given to environmental factors that influence the expression of tics. The number of studies in this area is still relatively small, and limitations often include retrospective design, absence of a control group and use of clinical rather than population-based samples. Furthermore, although the findings have generated interesting hypotheses, most have not been replicated. Generation of hypotheses is of course critical for scientific research, but a literature made up of many unreplicated findings risks the adoption of premature conclusions or may be dismissed altogether. Researchers on both sides of the Atlantic have argued recently for greater emphasis on studies that aim to replicate previous findings,8,9 and it has been said that reproducibility... is at the core of "the ...
This press release is available in French. Montreal, April 13, 2011 - The use of cognitive-behavioural therapy to treat tics in Tourette syndrome may be as effective as and even superior to medication in certain cases. According to a new study published in a special edition of the International Journal of Cognitive Therapy by researchers from the Fernand-Seguin Research Centre of the Louis-H. Lafontaine Hospital affiliated with Université de Montréal, it was observed that therapy has an effect not only on tics, behaviour and thoughts, but also on brain activity. "This discovery could have major repercussions on the treatment of this illness. In some cases, the physiological measures could allow for the improvement of the therapy in order to tailor it to a specific type of patient," states Dr. Marc Lavoie, certified researcher at Fernand-Seguin Research Centre of the Louis-H. Lafontaine Hospital and with the Psychiatry Department of Université de Montréal, who conducted this study with his ...
Tourette syndrome (TS) is an inherited disorder of the nervous system characterized by repeated involuntary movements and uncontrollable vocal (phonic) sounds called tics. In a few patients, such tics can include inappropriate words and phrases.
A new study conducted by Dr Clare Eddy and Dr Peter Hansen may help to explain the social content and emotional tone of many tics and compulsive urges in Tourette Syndrome (TS) patients.
LAWRENCE - Chances are, you know or have seen someone affected by Tourette syndrome (TS), a neurological disorder characterized by involuntary tics
Tourette syndrome affects the bodys brain and nervous system by causing tics - repeated, uncontrollable movements or involuntary vocal sounds.
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.. Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C.. Proc Natl Acad Sci U S A 112(3):893-898, 2015.. Postmortem studies of Tourette syndrome patients has revealed a reduction in the number of specific striatal interneurons. The authors explored the hypothesis that this neuronal deficit is enough to produce the symptoms of Tourette syndrome in mice. Animals received 90-ng injections of Anti-ChAT-SAP (Cat. #IT-42) into the striatum. Rabbit IgG-SAP (Cat. #IT-35) was used as a control. The data suggest that loss of the striatal interneurons is enough to produce some, but not all, of the symptoms caused by Tourette syndrome.. Role of striatal cholinergic interneurons in set-shifting in the rat.. Aoki S, Liu AW, Zucca A, Zucca S, Wickens JR.. J Neurosci 35(25):9424-9431, 2015.. The authors examined the role that ...
From BioPortfolio: Researchers have identified structural changes in two genes that increase the risk of developing Tourette syndrome, a neurological disorder characterized by inv...