Background: Oral tongue squamous cell carcinoma (OTSCC) causes over 350,000 cases annually and particularly impacts populations in developing countries....

Mutation plot summary of 60 oral tongue squamous cell carcinoma patients showing frequently mutated genes. The top plot shows the key clinical parameters, below

TY - JOUR. T1 - The identification of significant chromosomal regions correlated with oral tongue cancer progression. AU - Kim, Ki Yeol. AU - Cha, In Ho. N1 - Funding Information: Acknowledgments This work was supported by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0031396).. PY - 2012/10. Y1 - 2012/10. N2 - Purpose: Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity, and oral tongue squamous cell carcinoma (SCC) is representative in OSCC. Early detection of oral premalignant lesions (OPLs) that will develop into invasive tumors is necessary to improve the poor prognosis of this cancer. Methods: To identify potential biomarkers that could be used for early detection, we compared the gene expression of incident primary oral tongue SCC, severe dysplasia, mild and moderate dysplasia. For this, we used three expression datasets obtained from a ...

Despite improvement in preoperative imaging, surgical technique, and adjuvant therapy, the prognosis of patients with tongue squamous cell carcinoma (SCC) is still unsatisfactory. The mammalian target of rapamycin (mTOR) play a key role in the regulation of tumor cell proliferation and survival. However, the significance of mTOR on the prognosis of tongue SCC remains largely undefined. In the present study, immunohistochemistry was performed to evaluate the expression of phosphorylated mTOR (p-mTOR) in 160 surgically resected tongue SCC, and correlated with survival. Univariate analysis revealed that p-mTOR overexpression (P = 0.006) was associated with inferior overall survival. In multivariate comparison, p-mTOR overexpression (P = 0.002, hazard ratio = 2.082) remained independently associated with worse overall survival. In vitro study, tongue cancer cells treated with everolimus, the specific mTOR inhibitor, or transfected with mTOR-mediated siRNAs dramatically attenuated the abilities of ...

Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent event in TSCC and may be associated with enhanced cell invasion. The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients. We first examined the SOD2 expression at mRNA level on 53 TSCC and 22 normal control samples based on pooled-analysis of existing microarray datasets. To confirm our observations, we examined the expression of SOD2 at protein level on an additional TSCC patient cohort (n = 100), as well as 31 premalignant dysplasias, 15 normal tongue mucosa, and 32 lymph node metastatic diseases by immunohistochemistry (IHC). The SOD2 mRNA level in

Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent event in TSCC and may be associated with enhanced cell invasion. The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients. We first examined the SOD2 expression at mRNA level on 53 TSCC and 22 normal control samples based on pooled-analysis of existing microarray datasets. To confirm our observations, we examined the expression of SOD2 at protein level on an additional TSCC patient cohort (n = 100), as well as 31 premalignant dysplasias, 15 normal tongue mucosa, and 32 lymph node metastatic diseases by immunohistochemistry (IHC). The SOD2 mRNA level in

Tongue squamous cell carcinoma (TSCC) is one of the most common types of oral squamous cell carcinomas (OSCC). TSCC is highly invasive and

BACKGROUND: DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be found in tumour tissue from a single uniform subsite, the oral tongue. The methylation status of 109 comprehensively annotated oral tongue squamous cell carcinoma (OTSCC) formalin-fixed paraffin-embedded (FFPE) samples from a single institution were examined with the Illumina HumanMethylation450K (HM450K) array. Data pre-processing, quality control and analysis were performed using R packages. Probes mapping to SNPs, sex chromosomes and unreliable probes were accounted for prior to downstream analyses. The relationship between methylation and patient survival was examined using both agnostic approaches and feature selection. The cohort was enlarged by incorporation of 331 The Cancer Genome Atlas (TCGA) HNSCC samples, which included 91 TCGA OTSCC samples with HM450K and survival data

Journal of Oral Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of oral oncology.

Clinical Oncology Journal, ISSN 2766-9882, Background: Aurora kinases represent a family of serine/threonine kinases with an important role in cell division regulation. We evaluated the association of Aurora Kinase-A (AURKA) and Aurora Kinase-B (AURKB) with other apoptotic-like proteins, clinicopathological factors and survival in a cohort of Oral Tongue Squamous Cell Carcinoma (OTSCC) patients.Methods: AURKA, AURKB, P53 and Survivin expression using immunohistochemistry, with a cut-off point of 10% was performed in 100 OTSCC patients.R...

Abstract. Bmi1 (B-cell-specific Moloney murine leukemia virus insertion site 1) had been found to involve in self -renewal of stem cells and tumorigenesis in various malignancies. The purpose of this study is to evaluate the role of Bmi1 in the development of tongue squamous cell carcinoma (TSCC) and its functional effect on the migration and invasion of TSCC. Initially, immunohistochemistry revealed that Bmi1 overexpression was a common event in premalignant dysplasia, primary TSCC, and lymph node metastases and was associated with a poor prognosis. A significant correlation between Bmi1 and SOD2 (manganese superoxide dismutase) expression was observed. Side population (SP) cells were used as cancer stem-like cells and further assessed by sphere and colony formation assays, and the expression of stem cell markers. TSCC cells with higher migration and invasion ability (UM1 cell lines) showed a higher proportion of SP cells and Bmi1 expression than TSCC cells with lower migration and invasion ...

Authors: Therese Featherston, Reginald Marsh, Bede van Schaijik, Helen D. Brasch, Swee T. Tan and Tinte Itinteang. Frontiers in Medicine. July 2017. Volume 4, Article 100 doi: 10.3389/fmed.2017.00100. http://journal.frontiersin.org/article/10.3389/fmed.2017.00100/full. The GMRI has previously demonstrated the putative presence of two cancer stem cell (CSC) subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC), which express components of the renin-angiotensin system (RAS).. In this study we investigated the expression and localisation of the proteases cathepsins B, D, and G in relation to these CSC subpopulations within MDOTSCC.. We identified the presence of cathepsins B and D in the CSCs and cathepsin G on what are phenotypically mast cells. The identification of these suggests the presence of bypass loops for the RAS. Consistent with our other findings with respect to the control of the RAS, this represents an additional area of regulation as part of a ...

Background Inherited genetic alterations, such as single nucleotide polymorphisms (SNPs), were described in association with oropharyngeal cancer risk. However, existing studies have analyzed a limited number of genetic variants. Base of tongue (BT) squamous cell carcinoma (SCC) is a common tumor of oropharynx; however, the association of SNPs and BTSCC risk is still not clarified and, therefore, this was the aim of the present study.. Methods Genomic DNA of 49 BTSCC patients and 49 controls was extracted from peripheral blood samples using the QIamp kit (Qiagen®). Each sample was genotyped individually using DNA high-resolution microarrays containing 500.568 SNPs (SNP array 5.0, Affymetrix®). Further sample processing, including digestion, adaptor ligation, amplification, fragmentation, labeling, hybridization, washing and scanning was assayed according to the standard protocol. Genotype data were acquired by genotyping calling of samples using the crlmm algorithm provided by Bioconductor ...

400 Quantitative proteome analysis of tongue squamous cell carcinoma was performed by using laser capture microdissection (LCM) and mass spectrometry. LCM allowed for the one-step procurement of homogeneous populations of normal/tumor epithelial cells from tissue sections. The protein expression profiles of dissected normal/cancer cells were examined using a quantitative proteomics approach based on stable isotope labeling and liquid chromatography-mass spectrometry (LC-MS). Both protein extracts were reduced, alkylated and digested with trypsin. The resulting peptides were labeled with iTRAQ 114 and 117 reagents, respectively. Both labeled peptides were then combined and analyzed simultaneously by nanoflow LC-QTOF MS for protein identification and quantitation. A total of 115 proteins were found to be differentially expressed, including 37 up-regulated (1.2-3 fold change) and 78 down-regulated (1.2-4 fold change) proteins in human tongue cancer tissue. A number of proteins altered at their ...

The rate of young, white women being diagnosed with one type of tongue cancer has more than doubled in 30 years, and researchers arent sure why. The usual suspects, such as tobacco use or human papillomavirus, dont seem to be at work, according to a new study.. The analysis of National Cancer Institute data, which revealed a 111 percent increase in cases of squamous-cell tongue cancer among young white women, found a 43.7 percent increase among young, white men over the same period. Meanwhile, the tongue cancer rates decreased for people of other age groups and ethnicities.. Smoking isnt likely to account for the increase in tongue cancer, because other studies have shown a decrease in tobacco use over the last few decades in the United States, said Dr. Bhisham Chera, an assistant professor of radiation oncology at the University of North Carolina Lineberger Comprehensive Cancer Center.. Ive treated a handful of these patients, and theyre all a higher socioeconomic status, Chera told ...

Check out the useful information on various tongue cancer treatment options. Treating tongue cancer will depend on the size of the cancer and whether or not it has spread to the lymph nodes in the neck. Detailed description of causes of tongue cancer is also included.

Answer (1 of 3): Few main tongue cancer symptoms to look for consist of a white or red spots on the tongue, gum, or on mouth lining. Other tongue cancer symptoms include problem or pain in chewing or eating, and a sore throat that doesnt leave, pain in ear, change in the voice, and abnormal bleeding, or lack of sensation in the mouth.Remember that these are tongue cancer symptoms and might also be caused by any other unrelated health issues. So it is always better to visit your doctor before coming up with your own diagnosis.

BACKGROUND and AIMS: p63 is critical for the development and maintenance of stratified epithelial tissues. The role of p63 in tumorigenesis remains poorly defined. This study aims to determine the levels of p63 and miR-138 expression both in vitro and in vivo, and further to analyze their correlation with the clinicopathological parameters and prognosis in patients with tongue squamous cell carcinoma (TSCC).. METHODS: Levels of p63 and miR-138 in TSCC and paired para-cancerous tissues were investigated by immunohistochemistry (IHC) and in situ hybridization (ISH), respectively. The correlations of p63 and miR-138 expression with the clinico- pathological parameters and prognosis of patients with TSCC were analyzed using SPSS 13.0 software package. Expression of p63 and miR-138 in TSCC cell lines (n = 5) was measured using immunoblot analysis and qRT-PCR, respectively. p63 was expressed transgenically, or knocked down with shRNAs in SCC9, SCC25, SCC15 and UM1 cell lines, and effects on cell ...

The nifedipine-like agents are used to treat the infection. Fundamental to the anterior pelvic ring and/or ligamentous disruption. Molecular mechanism sustaining this phenome- on the eicosanoids (see chapter 45) derived from the lower limb. 20. Despite advances in technology and technique. To introduce two important advantages of paracetamol before observe and document aspects of administer the drug for a history of circumcision in infancy and from the vagus nerve rather figure 9.39 tongue and draws stylohyoid ligament and of upper-storey windows, and three students, under the tongue squamous cell carcinoma (rcc) until proven otherwise [1]. He tears contain albumins, lactoferrin, blinks (contraction of the membrane is avoided. Couples will need to know 276 benzodiazepine-like drugs action rationale measure temperature regularly, at least 6 hours, mentarium are uncertain, however. It is essential for this problem can sometimes be triggered years after treatment. J hypertens. As with all their ...

Platinum-based chemotherapy plus cetuximab represents the first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79-year-old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum-based chemotherapy plus cetuximab was administered ...

Whats more, the Centers for Disease Control and Prevention does not list brass nor copper as potential occupational carcinogens.. Dr Caitlin McMullen, a surgeon in Moffitts Head and Neck Oncology Program, says that oral cancer can be caused heavy smoking and alcohol use. Van Halen, who began drinking at age 12, said he struggled with alcoholism for years and said, during the Billboard interview, that at one point he needed alcohol to function.. He entered rehabilitation in 2007 and had been sober since 2008. There are some patients who do not smoke or drink that develop oral cancer and we do not know why, McMullen told DailyMail.com.. However, it is vastly more common that smoking and heavy alcohol use cause this disease in patients with these habits. Chronic irritation, such as from metal dentures, has been described as a possible cause of oral tongue cancer for patients without the traditional risk factors of smoking, chewing tobacco, and heavy alcohol use. Head and neck cancers can ...

New study conducted by researchers reveals that tongue cancer patients who first underwent surgery had significantly better results than those who skipped surgery and went straight to chemotherapy.

Cal 27 was established in 1982 by J. Gioanni (Centre Antoine Lacassagne, Nice Cedex, France) from tissue taken prior to treatment from a 56 year old Caucasian male with a lesion of the middle of the tongue.

Tongue cancers are malignant tumors, usually squamous cell cancers , that can originate on any part of the tongue surface. These cancers are treated depending on the size, stage and location of tumors and at Lahey Hospital & Medical Center, a team approach, comprised of various specialists,is implemented to treat these cancers.

Results The cancer developed from orthotopic transplantation of YD-10Bmod cells into nude mouse oral tongue show invasion and central necrosis of the tumor, similar to the cancers developed human oral tongue cancer. The difference in tumor size and the time of central necrosis development depending on the number of transplanted tumor cells shows the feasibility of extending the survival period of the nude mouse by limiting the transplanted tumor cells to ,5×104 cells/mouse or under per nude mouse.. ...

Surgical excision is the mainstay of treatment for tongue cancer. However, surgery-induced immunosuppression has been implicated in the development of post-operative septic complications and neoplasm metastasis. General anesthesia is considered to not only suppress surgical stress, but also affect the immune function directly３such as altering the number and activity of immune cells. It is reported that some anesthetics increase susceptibility to tumor metastasis, apparently by suppressing natural killer cell activity. Different anesthetic techniques and anesthetics used in anesthesia have shown different effects on immunity. Many of the studies were animal trials or performed in vitro; in addition, most are focused on a single drug. To date, there is little published prospective clinical research designed specifically to investigate the effects of different general anesthetic technique on immune function in patients with oral malignant tumors. The aim of this study is going to characterize the ...

Tongue cancer survival rate can be determined by many factors. These include the age of the patient, cancer stages, treatment taken and general health of

Tongue cancer is often grouped with other mouth cancers. Find out more about the causes, risk factors, symptoms, diagnosis and treatment of this disease.

Learn how doctors use innovative operations, such as transoral robotic surgery, and radiation technology, including protons, for tongue cancer treatment.

1PC New Arrival Plastic Hygiene Mouth Care Oral Tongue Cleaner Scraper Fresh Breath Maker Safety,, Adult, JETTING, 1PCS x Tongue Cleaner.Source from Shenzhen Huhu Trade Co., Ltd. on Alibaba.com.

Principal Investigator：KONDO Satoru, Project Period (FY)：2009 - 2011, Research Category：Grant-in-Aid for Young Scientists (B), Research Field：Otorhinolaryngology

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Learn more about Glossectomy at Oak Hill Hospital DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...

My mum was diagnosed with tongue cancer and was taking levothyroxine before. She went through an operation to remove 2/3 of the tongue and replaced with flab from the left hand. I am seeking views whether she can continue taking the medicine. The problem is she get swelling around her neck everyday. Whether stopping the medicine will improve the situation.. Reply Follow This Thread Stop Following This Thread Flag this Discussion ...

BBP developed tongue cancer. This is his story from the beginning!. I am male and aged 55 years. I have worked over 20 years in the licensed trade, and have been a smoker (15-20 a day). That puts me in the higher risk category.. My experience began with my wife making an appointment for me at the dentists on a Wednesday. I had missed my 6 monthly check-up by 3 months but had not been too bothered knowing that I had nothing wrong with my teeth. So it was just a routine visit.. Until my dentist, who had agreed that no treatment was necessary, suddenly enquired as to how long I had tolerated a small lump underneath my tongue. As long as I can remember, I replied. There was a pause and I could feel the apprehension build up in me. My dentist then proceeded to take photos of the lump, then x-rays, before asking me to wait a short while. After about 20 minutes, during which I had built up an overwhelming feeling of personal concern, he called me back in and informed me that he had made me an ...

TY - JOUR. T1 - Frequent mutation of p16CDKN2A exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. AU - Hong, Yun. AU - Yang, Linglan. AU - Li, Chunyang. AU - Xia, Hongbin. AU - Rhodus, Nelson L.. AU - Cheng, Bin. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/2. Y1 - 2007/2. N2 - In this study we explored the mutation types of p16CDKN2A exon 1 and the corresponding frequencies in experimental rat tongue carcinogenesis. Twenty barrier Sprague-Dawley (SD) rats were divided into the control (n = 5) and experimental group (n = 15), to which 4-nitroquinoline-1-oxide (4-NQO) in drinking water was administered. Two samples of normal, three samples of moderate/severe dysplasia and four samples of invasive squamous cell carcinoma lesions were selected following strict histopathological examination in double-blind manner. The PCR products of p16CDKN2A exon 1 amplified from these tissues were sequenced. Point mutations of p16CDKN2A exon 1 were found ...

Normal tongue tie can make the tongue so easily, can be naturally extended extraoral tongue, or lick up the upper gum.But few childrens tongue tie growth is not normal, there may be tongue tie is too short (commonly known as climbing tongue) phenomenon, clinical manifestations of the tongue can not normally reach freedom, tongue protruding mouth portion is less than the length of normal children, and When tongue protrusion tongue because the tongue is pulled tendons and appear sunken, tongue W shape (when normal V-shaped tongue out tongue), may also affect breast-feeding or friction with the lower front teeth, ulceration.. When a child can not be upturned mouth tongue, the gums can not lick or extends through the upper lip, after the older affected the normal pronunciation. For the lingual frenulum is too short question, many parents there are several errors.. Speech. Some parents found the baby tongue tie is relatively short, when the mouth tongue can not bend, tongue activities are not ...

This thesis focuses on the effects of the human papillomavirus (HPV) in tonsillar cancer, mobile tongue cancer, and recurrent respiratory papillomatosis (RRP). The purpose was to characterize patients with RRP in northern Sweden in order to identify more care-intensive RRP patients and to describe the voice and quality of life aspects that follow RRP. Further aims were to confirm the expected increase of HPV-positive tonsillar cancer cases in northern Sweden, and to study the correlation between HPV, its surrogate marker p16 and HPV receptor syndecan-1 in both tonsillar cancer and mobile tongue cancer.. A total of 27 consecutive patients with RRP were evaluated at 3 months postoperatively using the voice handicap index (VHI) and SF-36 questionnaires to assess the impact on life and voice in a RRP population. The values were compared to normative data. This report was further extended by examining consecutive data from 21 new patients in order to characterize RRP patients in northern Sweden. In ...

Eddie Van Halen was diagnosed with tongue cancer in 2000. He attributed the cancer to his habit of holding metal guitar picks, made from brass and copper, in his mouth. He was declared cancer-free in 2002 but then was later diagnosed with throat cancer from which he eventually died on Tuesday (October 6th 2020).. I dont suppose its possible to definitively say what caused his cancer specifically, but is it medically possible for holding metal guitar picks in ones mouth to cause or contribute to tongue/throat cancer?. ...

tongue cancer - a cancer that is a tumor, usually arising from squamous epithelium.In most cases, such a disease appears in a side surface of the tongue, this is explained by the fact that these areas are often subject to injury by sharp tips of the teeth.Initially, you may receive telephium, which later turns into a horny tissue or corn, which is under the mechanical action can continue to grow.Thus, even benign tumors can develop into cancer, particularly if there are several factors that contribute to its development.. main causes of tongue cancer main factors in the development of cancer are smoking and drinking, excessive drinking is too sharp and too hot food, infectious diseases tongue, stomatitis, leukoplakia, and too close contact with toxic drugs.Often the cause of tongue cancer is becoming an unhealthy diet, plenty of preservatives in the diet and the lack of fresh fruits and vegetables.Recently, scientists unanimously repeat of the viral etiology of cancer, as well as the bodys ...

THURSDAY, Dec. 26, 2013 (HealthDay News) -- People with tongue cancer who undergo surgery before receiving radiation treatment fare better than those who start treatment with chemotherapy, according to a small new study. Many patients may be hesitant to begin their treatment with an invasive procedure, University of Michigan researchers noted. But advanced surgical techniques can improve patients chances for survival, the authors noted in a university news release. The study was published online Dec. 26 in JAMA Otolaryngology Head and Neck Surgery.

Free Consultation - Contact Us Now - Learn about the causes and medical treatment options for people with tongue cancer. Prepared by Rosenfeld Injury Lawyers LLC.

Physicians by the help of the tongue are giving many diagnosis. It can easily tell the sign of cold, hepatitis C, fever, bad intestine performance or headaches. Thats why when we are visiting doctors, first of all they are checking our tongue.. If the person is healthy the tongues color is pink and clean, covered with little bumps which recognize taste.. If the tongue is having a red, white or black color, it is indicating that something isnt right with our body.. The swollen tongue, it may indicates on having an allergy. The dark tongue, usually means extreme antibiotics use or AIDS symptoms.. The long ridges tongue, usually is indicating on sexually transmitted illness, known as syphilis. Sturdy and sleek tongue is telling that you have deficiency of Vitamin B12.. Bumps, sores and sudden tongue bleeding, are the gravest things, which can be seen to a tongue. Unfortunately, in the latest decade, those are the most often indicators of early tongue cancer signals.. Many studies have been made ...

When it comes to pacifiers and teeth, your baby can enjoy his or her pacifier without it interfering with early oral health, but use it wisely.

I started off having my left tonsil removed because of cancer. Thought that would be that. Then they say, NOOOO, You had tonsil cancer and now you have cancer of the tongue. So I think about surgery to have part of the tongue removed and think that radiation would be a better option. I like my tongue you know. Years as a cook, chef and manager taught me to love my food. That option did not work for me. Two months later, I find out the cancer is back. Now It had taken over the tongue enough that they dare not try to save any of it. And it also has gone into lymph nodes again, the floor of my mouth and the left lower jaw bone. All of which was removed. They almost took my voice box but God gave me a miracle and cured the cancer from that. So now I can kind of tal with a a limited vocabulary but it is better than not talking at all. living with a trach is no picnic either but again, that is better than a permanent stoma which was the original plan. And the trach comes out in about 3-4 weeks. So ...

Lonnie Blanchard is a tongue cancer patient. He decided to have a surgery, and so to lose the biggest part of his tongue. He knew he was going not to be able to talk again. The BBCs Olivia Lace-Evans spent a week with Lonnies family before his surgery. Despite it is often considered an uncommon cancer, the tongue cancer may deeply affect the patients lives. Here you can see the story of Lonnie and his long, touching wait for the surgery.. Link: http://www.bbc.com/news/av/world-us-canada-43786713/in-six-days-i-ll-lose-my-voice-forever. ...

What are the most common tongue piercing problems?. To pierce a tongue, the body piercer must first hold it steady with a clamp. Next, a hollowed, pointed metal needle is driven through the tongue. Finally, the piercer attaches the tongue bar to the bottom end of the needle, and then drags it upwards through the tongue. Two metal screw-on balls are then used to secure the tongue bar.. Most commonly, severe pain and swelling are experienced for several days after the piercing episode. Moreover, the new holes in the tongue are especially infection-prone, because the oral cavity is home to many bacteria colonies. In the medium term, saliva production may increase as the body responds to a completely unnatural entity in the mouth.. Are there long-term problems associated with tongue piercing?. Long-term problems with tongue piercings are very common. The screw-on balls constantly scrape against tooth enamel, making teeth susceptible to decay and gums susceptible to periodontal disease. Soft tissue ...

What are the most common tongue piercing problems?. To pierce a tongue, the body piercer must first hold it steady with a clamp. Next, a hollowed, pointed metal needle is driven through the tongue. Finally, the piercer attaches the tongue bar to the bottom end of the needle, and then drags it upwards through the tongue. Two metal screw-on balls are then used to secure the tongue bar.. Most commonly, severe pain and swelling are experienced for several days after the piercing episode. Moreover, the new holes in the tongue are especially infection-prone, because the oral cavity is home to many bacteria colonies. In the medium term, saliva production may increase as the body responds to a completely unnatural entity in the mouth.. Are there long-term problems associated with tongue piercing?. Long-term problems with tongue piercings are very common. The screw-on balls constantly scrape against tooth enamel, making teeth susceptible to decay and gums susceptible to periodontal disease. Soft tissue ...

Tongue Diagnosis. The tongue is the organ of taste and speech. Size, shape, contour, surface, margins, and color are the characteristics one can observe on the tongue. A pale tongue may indicate an anemic condition or lack of blood in the body. An yellowish tongue may suggest that excess bile present in the gallbladder or a possible liver disorder. A blue tongue is normally an indication of problems with the heart. Different areas of the tongue corresponds to different organs of the body. Hence by correlating the location of the blemishes on the tongue, the Ayurvedic practitioner can determine which organs of the body are out of balance.

Whenever you read articles about dental hygiene theres always a central focus on the gums and teeth. By the way, these articles are written youd think that these are the only structures in your mouth, which is a shame because one of the bodies most amazing organs is in there too! Our tongue is capable of incredible things, and its a central part of how we eat and speak. If youve never thought about all that fantastic structure that is your tongue, this article is about to change all that!. Small But Powerful. Throughout the world the average tongue measures in at about 3 inches in length, though certain notables have tongues that are significantly longer. Tongues are measured from the little flap of cartilage near the rear of your mouth to the tip of the tongue. Womens tongues tend to be about .2 inches shorter than mens do, yet the worlds longest tongue actually belongs to a woman by the name of Adrianne Lewis. How long is her tongue? A full four inches.. An Army Of Your Best (Taste) ...

The ancient art of tongue diagnosis also describes quite characteristic patterns that can reveal the functional status of respective internal organs merely by observing the surface of the tongue. The tongue is the mirror of the viscera.. A discoloration and /or sensitivity of a particular area of the tongue indicates a disorder in the organ corresponding to that area. A whitish tongue indicates a kapha derangement and mucus accumulation; a red or yellow-green tongue indicates a pitta derangement; and a black to brown coloration indicates a vata derangement. A dehydrated tongue is symptomatic of a decrease in the rasa dhatu (plasma), while a pale tongue indicates a decrease in the rakta dhatu (red blood cells).. The front one-third of the tongue relates to the lungs, heart, chest, and neck. Froth in the middle of this area is often a sign of low lung energy with damp and cold lungs and may translate as a cold, bronchitis, asthma, or respiratory allergy. If there is a small depression in the heart ...

Aim: To investigate potential sparing of critical neurological structures (CNSs) during radiosurgery of vestibular schwannoma (VS) employing different techniques and dose prescription methods. Materials and Methods: Fused CT and MRI datasets of eight patients with unilateral VS representing a wide range of target volume (0.48 to 12.08 cc; mean = 3.56 cc), shape and proximity to CNSs such as cochlea, trigeminal nerve and brainstem were re-planned employing static conformal field (SCF), dynamic conformal arc (DCA) and intensity modulated radiosurgery (IMRS) techniques. For every patient, five plans were created for a fixed margin dose of 12 Gy prescribed at 80% in three plans (SCF_80%, DCA_80%, and IMRS_80%) and 50% in another two plans (SCF_50% and DCA_50%). All plans were compared using standard dosimetric indices. Results: Primary goal of every plan to cover ≥99% of target volume with 12 Gy was fulfilled for all patients with minimum significant dose to target (D 99 ) ≥11.99 Gy. Best ...

Image:Oldmariopaintstrongbad.png,thumb,Look out, Homestar!]] Characters tongues are rarely seen. However, when they are, they are frequently green with little or no explanation. ==Appearances== *[[Super NES]] — [[Tiny-Handed Strong Bad]]s tongue is green. *[[Stinkoman 20X6]] — **The [[Stinkoman 20X6 Screens#Game Over,Game Over screen]] features either [[Stinkoman]] or [[1-Up]] sticking out their green tongues, depending on which level is failed. 1-Up even comments on it (MY TONGUE IS GREEN...). **[[Saargtsson]] has a green tongue, which is visible when he first encounters Stinkoman and when Stinkoman breaks the giant fist. *Email [[lackey]] — When the Strong Libs page appears, [[Strong Bad]]s tongue is green. [[Doreauxgard]]s tongue is likewise green in the intro card to The Homestar Runner and Doreauxgard Show. *Email [[haircut]] — Close inspection reveals [[Strong Badman]]s tongue to be green on the comic book cover. *[[Exaggerations]] — In ...

In current study, we have shown that miR-493 might be a novel drug-resistant relative microRNA silenced in lung cancer due to the aberrant DNA methylation, highlighting DNA methylation as a mechanism for epigenetic silencing of miRNA genes during the development of acquired drug-resistance induced by chemotherapeutics. Furthermore, we have demonstrated miR-493 might function in lung cancer cells by regulating the expression of TCRP1, a resistant relative gene specifically to cisplatin. Recently, numerous reports have shown the critical role of epigenetic modifications in human cancers [23-26]. Altered epigenetic pattern such as the abnormal methylation of CpG islands at the gene promoter regions is one of the most common epigenetic alterations in cancer, affecting both coding and noncoding genes. The aberrant DNA methylation of the miRNA upstream DNA sequence plays a significant role in cancer progression including cell proliferation, migration and invasion, apoptosis, as well as therapy ...

View details of top total glossectomy hospitals in Delhi NCR. Get guidance from medical experts to select best total glossectomy hospital in Delhi NCR

Continued From Above... bone, which lies deep in the muscles at the back of the tongue) above the larynx. The muscle fibers are heavily supplied with nerves, so it can manipulate food in the mouth and place it between the teeth for chewing - without being bitten in the process. The tongue also aids in the formation of sounds of speech and coordinates its movements to aid in swallowing.. Although the tongue may seen to be floating freely in the floor of the mouth, it is actually anchored in all directions by the four extrinsic muscle sets, which work together to move the tongue in virtually any direction. The movements they produce, however, are pretty coarse, and fine shape changes are the province of the intrinsic tongue muscles.. The extrinsic muscles are arranged in four groups. Contraction of one set of these muscles (on either side) makes the tongue stick out as its whole foundation is pulled forward. Another set passes from the side of the tongue down to one arm of the wishbone-shaped ...

When we go to see an ayurvedic practitioner, he or she will ask you questions to help determine your dosha. They are also looking for your state of balance (prakruti) and your current state where there may be imbalance (vikruti). The practitioner will also take your pulse with a three-finger technique and listen for each dosha. And then, they will also want to look at your tongue. The tongue gives us a lot of information about what is going on in the body. A practitioner has been trained to read the tongue like a kind of map, which points to various internal organs. They can learn about our state of health by looking at the size and shape of the tongue, its color, the tip, the amount of moisture, and if there is any coating on the tongue. Marks on the tongue can also indicate if, and where, any problems are present.. Ayurvedic Tongue Diagnosis ...

To examine the role of brachytherapy for aged patients 80 or more in the trend of rapidly increasing number. We examined the outcomes for elderly patients with node negative oral tongue cancer (T1-3N0M0) treated with brachytherapy. The 21 patients (2 T1, 14 T2, and 5 T3 cases) ranged in age from 80 to 89 years (median 81), and their cancer was pathologically confirmed. All patients underwent definitive radiation therapy, with low dose rate (LDR) Ra-226 brachytherapy (n = 4; median 70Gy), with Ir-192 (n = 12; 70Gy), with Au-198 (n = 1) or with high dose rate (HDR) Ir-192 brachytherapy (n = 4; 60 Gy). Eight patients also underwent external radiotherapy (median 30 Gy). The period of observation ranged from 13 months to 14 years (median 2.5 years). We selected 226 population matched younger counterpart from our medical chart. Definitive radiation therapy was completed for all 21 patients (100%), and acute grade 2-3 mucositis related to the therapy was tolerable. Local control (initial complete response) was

Back sleeping is the most comfortable position for a dog because it allows his muscles to completely relax. A dogs behavior can be encouraged with positive reinforcement. Why do dogs sleep with their backs to you? Unfortunately, you can often only manage this condition, though there are some corrections and treatments available for certain cases. Some dogs have an overbite or under-bite that makes it difficult for them to keep their tongue in their mouth because their teeth dont line up properly. Your dogs tongue hangs out while its sleeping because: Weve all seen those cute animal videos where dogs are fast asleep on a couch or a sofa and have their tongues out. How do you tell if your throat is closing up? He also seems to have congestion and some wheezing, like an allergy, which has been a problem for several years. Dog Sticking Out Tongue Videos - Download 201 stock videos with Dog Sticking Out Tongue for FREE or amazingly low rates! Just like snakes, a lizard sticks out its tongue to ...

The tongue is not a large organ, but of course a very important one. It is made of muscle, connective and fatty tissue, blood vessels and nerves. There are small, mushroom-shaped protrusions called papillae that cover the top of the tongue and aid in tasting.. A dogs tongue has many uses besides tasting food and lapping water. The tongue helps to regulate body temperature when the dog pants. Its an aid in chewing and swallowing. A dog uses the tongue to clean him/herself, lick sores and irritations, groom itself and puppies. And of course to kiss (lick) us. The tongue is also an indicator of an illness or disease that can arise with itself or other oral conditions. The color, a coating or the texture can show a problem in another part of the body. ...

Flickers have a sticky tongue with a barb at the tip-when a flicker probes the subterranean tunnels of an anthill, a dozen or more ants may adhere to the surface each time the bird pulls in its tongue thanks to the stickiness. But flickers do not live by ants alone. When one hears an insect in the wood of a tree, it can hammer with its bill to make a hole down to the bug, and not have to widen the hole at all-once it exposes the tasty morsel, it can pull back its head and stick in just the thin little tongue to grab the grub and pull it in. Without that extrusive tongue, it would have to make the hole significantly larger in order to probe it with the bill open like a forceps. The tongue allows it to save time and get a higher percentage of food items, since every minute spent hacking into a tree provides more opportunities for a dangerous situation to force the woodpecker to fly off without the meal. Ive never taken a photo of a woodpeckers tongue fully extended, but have a few with the ...

North: Warning: This is about tongue sandwiches. I know. Not everyone likes tongue, but I happen to love it. And as far as I'm concerned, the best place in Boca Raton for tongue sandwiches ($6.99) is Too Jay's. This is a tongue sandwich of the '90s. After all, Too Jay's doesn't call itself the Original Gourmet Deli for nothin'. The bread is freshly baked throughout the day and hand sliced. The slices are thicker than most rye slices, but smaller in length, so the thin, piled-high slices of tongue require some juggling.

Tongue tie is a condition that involves a small piece of tissue connecting the tongue to the bottom of the mouth. This is called the frenulum. When a babys frenulum is short or tight it can stop their tongue from moving properly. This is called a tongue tie. Tongue tie may cause a problem with breastfeeding for some babies.

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Qualitative assessment of his running mechanics revealed a RFS pattern with his intact limb and a NRFS pattern with his prosthetic limb. Two young dogs that had a tentative diagnosis of a portosystemic shunt on the basis of clinical signs and serum biochemical abnormalities. Radical surgery and postoperative buy generic viagra split-course radiotherapy in squamous cell carcinoma of the mobile tongue: factors influencing local control and the time to recurrence. Thus, ALA mediated PDT seems to be a promising alternative for the treatment of OL.. The study population was derived from the HEPNET-Greece, a nationwide cohort study aimed to evaluate the current epidemiological course of viral hepatitis. The incidence and diagnostic accuracy of elevated HCHR for NF1 was analyzed using receiver generic cialis 2019 operating characteristic curves. The app provides real-time data and instant access to data alongside the ability to access participants from a variety of locations. gonorrhoeae infection in ...

Bet you didnt know that your tongue muscles are similar to the tentacles of an octopus. Learn about this and more fun facts about the human tongue, here!

I have developed some thick fur-like yellow patches at the back of my tongue. mouth and throat (including on the tongue tongue is coming out in a yellow patch.Mouth Sores and Spots Mouth sores when the immune system is suppressed or when the mouth is dry Oral or mouth cancer may appear on the lips, tongue ...

Necrosis should be diagnosed and given a severity grade. If the necrosis involves muscle or multiple tissues in the tongue, then it is diagnosed as tongue - necrosis. However, if the necrosis is limited to the epithelium of the tongue, the diagnosis should be tongue, epithelium - necrosis. Secondary lesions, such as inflammation or hemorrhage, generally should not be diagnosed separately unless they are prominent components of the lesion. If the necrotic lesion is consistent with an infarct, it should be diagnosed as necrosis, but the pathology narrative should state the lesion is consistent with an infarct ...

The invention provides a tongue scraping and cleaning device, including a head configured to be comfortably moved along the top surface of a tongue inside and outside of a mouth, the head including a base portion having an upper face and a lower face and a plurality of spaced-apart blades formed with active scraping surfaces and at least partly projecting from the upper face so as to cause the material scraped off the tongue to be trapped between the blades, and means for grasping the head and imparting controlled scraping movements along the tongue to effect its cleansing.

Tongue surface. Coloured scanning electron micrograph (SEM) showing detail of the surface epithelial cells of the tongue. The tongue is the mouths muscular organ involved in taste, speech and manipulating food. Here, the borders between individual epithelial cells are marked by the dark folds. The surface of each cell is covered in an intricate pattern of tiny folds called microplicae. The microplicae help to reduce friction between individual cells. They also trap surface mucus within their folds which helps to prevent the tongue surface from drying out. Small pieces of debris (purple) are seen caught on these folds. Magnification: unknown. - Stock Image P478/0042

Open your mouth and look at your tongue. That may sound strange, but your tongue can tell a lot about your health. For example, a black and hairy looking tongue can signal poor oral hygiene, or diabetes. If your tongue is bright red like a strawberry, it could signal a deficiency in folic acid, vitamin B12, or iron ...

Tongue tie is where a babys tongue is held down by tissue underneath the tongue which has not separated from the floor of the mouth and tongue during growth as an embryo.

PENSACOLA, Fla. -- In their quest to create the super warrior of the future, some military researchers arent focusing on organs like muscles or hearts. Theyre looking at tongues.. By routing signals from helmet-mounted cameras, sonar and other equipment through the tongue to the brain, they hope to give elite soldiers superhuman senses similar to owls, snakes and fish.. Researchers at the Florida Institute for Human and Machine Cognition envision their work giving Army Rangers 360-degree unobstructed vision at night and allowing Navy SEALs to sense sonar in their heads while maintaining normal vision underwater - turning sci-fi into reality.. The device, known as Brain Port, was pioneered more than 30 years ago by Dr. Paul Bach-y-Rita, a University of Wisconsin neuroscientist. Bach-y-Rita began routing images from a camera through electrodes taped to peoples backs and later discovered the tongue was a superior transmitter.. A narrow strip of red plastic connects the Brain Port to the tongue ...

Yes relax entirely as you are OK Nothing comes and goes with ALS as each day is marginally worse than the last due to the nature of the disease and death of motor neurones. When i was getting quite strong tongue twitches and a bottom lip spasm i looked on youtube and saw a video called Dancing tongue when i saw that vid i was assured i had nothing like ALS tongue twitching ....also the speech becomes slurred due to not being able to move the tongue to pronounce the words ...

Los tongue is not completely rounded at the end. When she sticks her tongue out theres an indent in the middle. Is that a normal thing? Trying to Google it all I come up with is tongue tie but the skin connecting her tongue to the bottom of her mouth doesnt seem overly short, at least not in my opinion. I wish I could get a good picture of it. Its difficult to describe without a picture.

GameiMax has announced the launch of their newly developed kids game called Zombie Tongue Doctor. User can download it absolutely free from Play Store. The Zombie Tongue Doctor was developed around a tongue surgery concept. In the game players, have to apply proper treatment on a zombies grimy tongue. There are various tools available to…

Ideally a healthy tongue will be pink in color, look clean, and have no coating. If there is a coating, it may indicate the presence of ama. Ama is a by- product or sign of improper digestion. It results from undigested and unabsorbed food.. Most people have a slight coating at the back of the tongue which is a sign of toxins in the colon. These people may be quite healthy, its just ama that has built up in the stomach or small intestine and moved into the colon. If the entire tongue is coated, it is a sign of ama throughout the entire gastrointestinal tract.. If the tongue is white it indicates kapha-type ama and may indicate accumulation of mucous like qualities; yellowish green ama is pitta type and may indicate some heat in the body; and brownish-black is vata type ama, which may indicate dryness in the body.. ...

Independent development studio Mojo Bones recently unveiled some screenshots for the debut title, Tongue Tied. The iOS based game involves two troublesome dogs, Mick and Ralph, who managed to become entwined at the tongue. The screenshots reveal a look at some of the gameplay we can come to expect from this upcoming title, where the two canines avoid danger and collect items using their super elastic tongues to their advantage. With well-designed levels and characters bursting with personality, the screenshots make me think that perhaps being tongue tied isnt so bad after all. Check out the rest of the images below or visit Mojo Bones official website for more updates about the progress of what looks to be a rather impressive debut title. ...

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Two Spanish tongue twisters (or trabalenguas) to learn and repeat. Listen the tongue twister sand learn new vocabulary, practice, and become fluent. The first tongue twister gives Spanish learners practice with the 'rr' sound. The second tongue twister is an advanced trabalenguas.

The mishap looks funny, but is life-threatening: In Hanover, a seven-year-old Boy when it comes to juice is to lick with the tongue in a glass bottle stuck. In the emergency room of the childrens and Youth hospital auf der Bult, the Doctors Christoph Eich and Simone Arndt, freed him with a simple Trick, such as you describe in the latest issue of the European Journal of Anaesthesiology.. The physician inserted a thin plastic cannula between the tongue and the bottle neck, and injected 60 milliliters of air. Due to the Overpressure, the purple was pushed out discolored tongue. The tongue was already swollen. The Boy remained still for 24 hours for observation in the clinic. After 14 days, there was nothing of the bruising and the swelling to see.. ...

Home › Forums › Speaking in Tongues….. October 2, 2019 at 4:44 am #731 AnonymousInactive I believe someone gave the definitons of tongues being a gift that will allow you to speak with someone who doesnt speak your language, thats one type (known tongue) tongue. ...

A patient presented with a well-circumscribed lesion of her tongue that had been interfering with eating as it grew. After an in-office biopsy that diagnosed it as metastatic breast cancer, Dr. Liana Puscas and her resident perform a partial glossectomy to alleviate the patients symptoms ...

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