TY - JOUR. T1 - Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population. AU - Hatanaka, Kunihiko. AU - Doi, Masayuki. AU - Hirohata, Satoshi. AU - Kamikawa, Shigeshi. AU - Kaji, Yoko. AU - Katoh, Tsutomu. AU - Kusachi, Shozo. AU - Ninomiya, Yoshifumi. AU - Ohe, Tohru. PY - 2007. Y1 - 2007. N2 - Background: Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease. Methods and Results: Two hundred and six consecutive patients who underwent an adenosine infusion (120•g•·kg-1·min-1) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary ...
TY - JOUR. T1 - Are shades of gray prognostically useful in reporting myocardial perfusion single-photon emission computed tomography?. AU - Abidov, Aiden. AU - Hachamovitch, Rory. AU - Hayes, Sean W.. AU - Friedman, John D.. AU - Cohen, Ishac. AU - Kang, Xingping. AU - Yang, Ling De. AU - Thomson, Louise. AU - Germano, Guido. AU - Slomka, Piotr. AU - Berman, Daniel S.. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2009/7. Y1 - 2009/7. N2 - We have advocated the use of a 5-category normal, probably normal, equivocal, probably abnormal, and definitely abnormal approach to final interpretation of myocardial perfusion single-photon emission computed tomography (SPECT). The prognostic value of expressing levels of certainty compared with a dichotomous normal/abnormal classification or categories for summed stress scores is unclear. Methods and Results-Myocardial perfusion SPECT (MPS) was visually assessed using a standard semiquantitative approach, yielding ...
Methods and Results-We randomized symptomatic women with suspected CAD, an interpretable ECG, and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies: ETT or exercise MPI. The primary end point was 2-year incidence of major adverse cardiac events, defined as CAD death or hospitalization for an acute coronary syndrome or heart failure. A total of 824 women were randomized to ETT or exercise MPI. For women randomized to ETT, ECG results were normal in 64%, indeterminate in 16%, and abnormal in 20%. By comparison, the exercise MPI results were normal in 91%, mildly abnormal in 3%, and moderate to severely abnormal in 6%. At 2 years, there was no difference in major adverse cardiac events (98.0% for ETT and 97.7% for MPI; P=0.59). Compared with ETT, index testing costs were higher for exercise MPI (P,0.001), whereas downstream procedural costs were slightly lower (P=0.0008). Overall, the cumulative diagnostic cost savings was 48% for ETT compared with ...
TY - JOUR. T1 - Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly. AU - Hachamovitch, Rory. AU - Kang, Xingping. AU - Amanullah, Aman M.. AU - Abidov, Aiden. AU - Hayes, Sean W.. AU - Friedman, John D.. AU - Cohen, Ishac. AU - Thomson, Louise E.J.. AU - Germano, Guido. AU - Berman, Daniel S.. PY - 2009/12. Y1 - 2009/12. N2 - BACKGROUND- The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (,75 years of age). METHODS AND RESULTS: We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8±1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) and a subset with extended follow-up (684 patients for 6.2±2.9 years; 320 all-cause deaths). Survival modeling of CD revealed that both MPS-measured ischemia and fixed defect added incrementally to pre-MPS data in both adenosine and exercise stress patients. Modeling a subset with gated MPS (n=2472) revealed ...
TY - JOUR. T1 - Semi-quantitative ventilation/perfusion scintigraphy and single-photon emission tomography for evaluation of lung volume reduction surgery candidates. T2 - Description and prediction of clinical outcome. AU - Jamadar, David A.. AU - Kazerooni, Ella A.. AU - Martinez, Fernando J.. AU - Wahl, Richard L.. PY - 1999/7/29. Y1 - 1999/7/29. N2 - Ventilation/perfusion scans with single-photon emission tomography (SPET) were reviewed to determine their usefulness in the evaluation of lung volume reduction surgery (LVRS) candidates, and as a predictor of outcome after surgery. Fifty consecutive planar ventilation (99mTc-DTPA aerosol) and perfusion 99mTc-MAA) scans with perfusion SPET of patients evaluated for LVRS were retrospectively reviewed. Technical quality and the severity and extent of radiotracer defects in the upper and lower halves of the lungs were scored from visual inspection of planar scans and SPET data separately. An emphysema index (EI) (extent x severity) for the upper ...
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up ...
TY - JOUR. T1 - EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2. AU - Kapucu, Özlem L.. AU - Nobili, Flavio. AU - Varrone, Andrea. AU - Booij, Jan. AU - Vander Borght, Thierry. AU - Någren, Kjell. AU - Darcourt, Jacques. AU - Tatsch, Klaus. AU - Van Laere, Koen J.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - These guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The purpose of the guidelines is to assist nuclear medicine practitioners when making recommendations, performing, interpreting, and reporting the results of brain perfusion single photon emission computed tomography (SPECT) studies using 99mTc- labelled radiopharmaceuticals. The aim is to achieve a high quality standard for brain perfusion SPECT imaging, which will increase the diagnostic impact of this technique in clinical practice. The present document replaces a former version of the guideline published in 2001 ...
Brain perfusion SPECT is highly useful for the diagnosis of the dementias, including Alzheimers disease, Fronto-Temporal Dementia, and Lewy Body Disease. Studies of the accuracy of SPECT for diagnosing Alzheimers Disease report sensitivities of 65%-85% and specificities (for other dementias) of 72%-87% (1) In the largest study to date, both HMPAO SPECT and 18F-FDG PETwere able to completely separate 26 AD cases from controls (2) SPECT has been advocated over18F-FDG PET on the basis of its wider availability, lower cost, and perceived better patient tolerability, although a recent review suggested 18F-FDG PET had greater diagnostic accuracy over Brain Perfusion SPECT where available (3) Guidelines of the European Association of Nuclear Medicine and the American College of Radiology endorse the clinical use of Brain Perfusion SPECT in the workup and diagnosis of dementia (4,5).. Brain perfusion SPECT is useful because the clinical diagnosis of dementia is often inaccurate, especially in early ...
Background: Non-invasive diagnostic imaging of atherosclerotic coronary artery disease (CAD) is frequently carried out with cardiovascular magnetic resonance imaging (CMR) or myocardial perfusion single photon emission computed tomography (MPS). CMR is the gold standard for the evaluation of scar after myocardial infarction and MPS the clinical gold standard for ischemia. Magnetic Resonance Imaging (MRI) is at times difficult for patients and may induce anxiety while patient experience of MPS is largely unknown.. Aims: To evaluate image quality in CMR with respect to the sequences employed, the influence of atrial fibrillation, myocardial perfusion and the impact of patient information. Further, to study patient experience in relation to MRI with the goal of improving the care of these patients.. Method: Four study designs have been used. In paper I, experimental cross-over, paper (II) experimental controlled clinical trial, paper (III) psychometric crosssectional study and paper (IV) ...
RATIONALE AND OBJECTIVES: In the general context of perfusion pattern modeling from single-photon emission computed tomographic (SPECT) data, the purpose of this study is to characterize interindividual functional variability and functional connectivity between anatomic structures in a set of SPECT data acquired from a homogeneous population of subjects. MATERIALS AND METHODS: From volume of interest (VOI)-perfusion measurements performed on anatomically standardized SPECT data, we proposed to use correspondence analysis (CA) and hierarchical clustering (HC) to explore the structure of statistical dependencies among these measurements. The method was applied to study the perfusion pattern in two populations of subjects; namely, SPECT data from 27 healthy subjects and ictal SPECT data from 10 patients with mesio-temporal lobe epilepsy (MTLE). RESULTS: For healthy subjects, anatomic structures showing statistically dependent perfusion patterns were classified into four groups; namely, temporomesial
A very simple and low-cost brain dedicated, rapidly rotating Single Photon Emission Tomograph SPECT is described. Its use in following patients with ischemic stroke is illustrated by two middle cerebral artery occlusion cases, one with persistent occlusion and low CBF in MCA territory, and one with early lysis of the occlusion having high CBF (massive luxury perfusion) for some weeks. Evidence of this kind may be essential in the evaluation of therapeutic measures in ischemic stroke. ...
Background: It is of great clinical importance to exclude myocardial infarction in patients with suspected coronary artery disease who do not have stress-induced ischemia. The diagnostic use of myocardial perfusion single-photon emission computed tomography (SPECT) in this situation is sometimes complicated by attenuation artifacts that mimic myocardial infarction. Imaging in the prone position has been suggested as a method to overcome this problem. Methods: In this study, 52 patients without known prior infarction and no stress-induced ischemia on SPECT imaging were examined in both supine and prone position. The results were compared with cardiac magnetic resonance imaging (CMR) with delayed-enhancement technique to confirm or exclude myocardial infarction. Results: There were 63 defects in supine-position images, 37 of which disappeared in the prone position. None of the 37 defects were associated with myocardial infarction by CMR, indicating that all of them represented attenuation ...
Tracking coronary artery disease (CAD) via myocardial perfusion imaging (MPI) may have value in guiding therapeutic management for minimizing coronary event risk. Few studies have evaluated the effects of changes in myocardial perfusion as measured by positron emission tomography (PET MPI) on clinical outcomes. Accordingly, this study identified 552 patients who underwent serial rubidium-82 PET MPI for evaluation of suspected or known CAD. The extent of left ventricular (LV) stress perfusion defects was measured at both scans Objectivesly by automated software as the percentage of the LV mass with ,60% relative perfusion. All patients received aggressive medical therapy and 12% underwent interim revascularization. Mortality information was obtained through the National Death Index with mean follow-up of 2.5 years. Cox models were developed to estimate the effects of changes in stress perfusion defect size (change between serial scans in % of LV with stress perfusion defects) on all-cause and ...
TY - JOUR. T1 - Coronary stenosis severity assessed by 256-slice MDCT angiography in comparison with stress myocardial perfusion imaging. AU - Yonezawa, Masato. AU - Higuchi, K.. AU - Yamazaki, Y.. AU - Jinnouchi, M.. AU - Maruoka, Y.. AU - Isoda, T.. AU - Kamitani, T.. AU - Baba, S.. AU - Matsuo, Y.. AU - Abe, K.. AU - Honda, H.. PY - 2012/1/10. Y1 - 2012/1/10. N2 - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the diagnostic accuracy of MDCT for detecting myocardial ischemia by 201Tl SPECT. Fifty-three patients underwent both coronary CT angiography and stress myocardial perfusion SPECT. All coronary arteries were assessable with appropriate image quality. MDCT revealed high specificity, but only half of stenotic lesion by MDCT revealed ischemia on SPECT.. AB - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the ...
Objectives. We sought to evaluate the clinical use and cost-analysis of acute rest technetium-99m (Tc-99m) tetrofosmin single-photon emission computed tomographic (SPECT) myocardial perfusion imaging in patients with chest pain and a normal electrocardiogram (ECG).. Background. Current approaches used in emergency departments (EDs) for treating patients presenting with chest pain and a nondiagnostic ECG result in poor resource utilization.. Methods. Three hundred fifty-seven patients presenting to six centers with symptoms suggestive of myocardial ischemia and a nondiagnostic ECG underwent Tc-99m tetrofosmin SPECT during or within 6 h of symptoms. Follow-up evaluation was performed during the hospital period and 30 days after discharge. All entry ECGs, SPECT images and cardiac events were reviewed in blinded manner and were not available to the admitting physicians.. Results. By consensus interpretation, 204 images (57%) were normal, and 153 were abnormal (43%). Of 20 patients (6%) with an acute ...
For thousands of years, we, as humans, have sought to understand the mechanisms responsible for neural activity (Walsh, 1978). As long ago as 10,000 B.C., craniotomies are known to have been performed. In the 1500s, Vesalius published the first anatomic drawings of the brain after an unprecedented observation and dissection of the brain. In the 19th century, lesion studies introduced the lesion/deficit hypothesis of neural functioning, which subsequently led to much of the current functional neuroanatomical terminology (e.g., Brocas and Wernickes areas). Through the last few decades of what may be considered modern neural research, a greater interest in the cognitive correlates of structural and functional brain lesions has led to the development of todays technology for imaging the nervous system (Mega, 1999, p. 41 ...
Pharmacologic stress with dipyridamole has provided useful diagnostic, as well as prognostic, information in patients undergoing thallium-201 myocardial perfusion imaging. With its ultrashort half-life and a potent and consistent vasodilator effect, adenosine may be the coronary vasodilator of choice with myocardial perfusion imaging.. Fifty-one healthy subjects and 93 patients with suspected coronary artery disease constituted the study group. In this multicenter study the comparative safety and diagnostic efficacy of single-photon emission computed tomography (SPECT) thallium imaging during adenosine-induced coronary hyperemia was compared with exercise treadmill stress. There was a mean increase in heart rate of 37% and a mean decrease in diastolic blood pressure of 5% during the adenosine infusion of 140 μg/kg per min for 6 min. Adenosine infusion was well tolerated in 95% of the subjects. Side effects requiring intervention occurred in seven subjects (5%). None of the subjects experienced ...
DaTscanTM Ioflupane I123, a radiopharmaceutical will be used as an adjunct diagnostic tool in combination with single photon emission computed tomography
Dive into the research topics of Phantom evaluation of simultaneous thallium-201/technetium-99m aquisition in single-photon emission tomography. Together they form a unique fingerprint. ...
Different software tools for quantification of myocardial perfusion SPECT (MPS) studies are routinely used. Several perfusion parameters can be computed automatically. Interpretation of the MPS should start with visual inspection of the rotating planar images, visual analysis of reconstructed SPECT slices and then quantitative analysis to confirm the visual impression. Quantification should be used routinely as complementary to visual analysis. Advantages of quantification are: greater confidence in interpretation, better reproducibility, diagnostic accuracy and measuring the degree of abnormality even subtle changes for serial comparisons. In this review, we look at the common features of such quantitative tools: 17-segment scoring system, polar maps including: raw, severity and extent polar maps, lung-to-heart ratio, transient ischemic dilation ratio, total perfusion deficit and spherecity index.
TY - JOUR. T1 - Cardiac contraction motion compensation in gated myocardial perfusion SPECT. T2 - A comparative study. AU - Salehi, Narges. AU - Rahmim, Arman. AU - Fatemizadeh, Emad. AU - Akbarzadeh, Afshin. AU - Farahani, Mohammad Hossein. AU - Farzanefar, Saeed. AU - Ay, Mohammad Reza. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Introduction: Cardiac contraction significantly degrades quality and quantitative accuracy of gated myocardial perfusion SPECT (MPS) images. In this study, we aimed to explore different techniques in motion-compensated temporal processing of MPS images and their impact on image quality and quantitative accuracy. Material and method: 50 patients without known heart condition underwent gated MPS. 3D motion compensation methods using Motion Freezing by Cedars Sinai (MF), Log-domain Diffeomorphic Demons (LDD) and Free-Form Deformation (FFD) were applied to warp all image phases to fit the end-diastolic (ED) phase. Afterwards, myocardial wall thickness, myocardial to blood pool ...
The evaluation of stress-induced myocardial perfusion defects by non-invasive myocardial perfusion imaging (MPI) modalities has a leading role in the identification of coronary artery disease, and has excellent diagnostic and prognostic value. Non-invasive MPI can be performed using conventional and novel gamma cameras or by PET/CT. New software has allowed novel parameters that may have a role in the identification of early marks of cardiac impairment to be evaluated. We aim to give an overview of niche parameters obtainable by single photon emission CT (SPECT) and PET/CT MPI that may help practitioners to detect initial signs of cardiac damage and identify new therapy targets. In particular, we summarise the role of left ventricular geometry indices for remodelling, phase analysis parameters to evaluate mechanical dyssynchrony, the concept of relative flow reserve in the evaluation of flow-limiting epicardial stenosis, vascular age and epicardial adipose tissue as early markers of atherosclerotic
TY - JOUR. T1 - Gastric accommodation measurements by single photon emission computed tomography and two-dimensional scintigraphy in diabetic patients with upper gastrointestinal symptoms. AU - Chedid, Victor. AU - Halawi, Houssam. AU - Brandler, Justin. AU - Burton, Duane. AU - Camilleri, Michael. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objective: To compare estimates of gastric accommodation (GA) with single photon emission computed tomography (SPECT) to measurements based on intragastric meal distribution immediately post-meal ingestion (IMD 0 ). Methods: We evaluated 108 diabetics with upper gastrointestinal (UGI) symptoms who had undergone gastric emptying of solids (GE) by scintigraphy and GA measurements by SPECT. Immediately after ingestion of a 99m Tc-labeled egg meal (time 0), we estimated IMD 0 as radioactive counts or area of the proximal half of the stomach on two-dimensional images. Gastric volume (GV) during fasting and after 300 mL Ensure ® was measured by SPECT to quantify ...
Purpose: Shortening scan time and/or reducing radiation dose at maintained image quality are the main issues of the current research in radionuclide myocardial perfusion imaging (MPI). We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time). Methods: In this study, 50 patients, referred for evaluation of known or suspected coronary artery disease by SPECT MPI using 99mTc-Tetrofosmin, underwent 1-day adenosine stress 300MBq/rest 900MBq protocol with standard (stress 15min/rest 15min FULL time) immediately followed by short emission scan (stress 9min/rest 7min HALF time) on a Ventri SPECT camera (GE Healthcare). FULL time scans were processed with IR, short scans were additionally processed with a recently developed software algorithm for HALF time emission scans. All reconstructions were subsequently analyzed using commercially available software (QPS/QGS
Few-view single photon emission computed tomography (SPECT - Imaging: PET and SPECT Positron Emission Tomography Single Photon Emission Computed Tomography
Abstract. Background: An analysis of the US National Cardiovascular Data Registry has revealed that only 38% of patients referred for coronary angiography after non-invasive coronary testing have relevant coronary obstruction (CO) (≥70%) of one or more coronary arteries.. Methods: A single-center trial was undertaken in 165 consecutive, symptomatic patients with either known or suspected coronary disease and/or valve disease(VHD) who agreed to undergo cardiac catheterization and coronary angiography if stress myocardial perfusion imaging was abnormal. A total of 116 patients with abnormal SPECT MPI tests, persistent chest pain, or significant VHD underwent final analysis. An MCG coronary obstruction (CO) score of ≥ 4.0 was considered indicative of relevant CO (≥70%) in one or more coronary arteries. Angiographic results were finalized by consensus of two angiographers.. Results: CO (≥70%) was present in 53 of 116 patients (46%). The MCG CO score was significantly higher for patients with ...
Reductions in regional cerebral perfusion, particularly in the posterior temporo-parietal lobes, are well recognized in Alzheimers disease. We set out to correlate perfusion changes, using (99m)Tc-HMPAO single photon emission tomography (SPET), with the pathological stage of Alzheimers disease. The Braak stage of the distribution of neurofibrillary pathology in post-mortem brains was used to classify SPET scans taken in life from a mixed (dementia and control) elderly population into the entorhinal stage (n = 23 subjects), limbic stage (n = 30 subjects) and neocortical stage (n = 36 subjects) Alzheimers disease pathology. The SPET scans were then registered to a common, standard Talaraich space, and single template scans produced for each pathological stage. Comparison of these templates revealed an evolution in the pattern of reduction in regional perfusion. Additional comparisons were performed using earlier SPET scans obtained 5 years before death. For comparisons between templates, a threshold
TY - JOUR. T1 - Comparison of echocardiography with technetium 99m-gated single photon emission computed tomography as diagnostic tools for left ventricular ejection fraction. AU - Choragudi, Nagaraju L.. AU - Prakash, Anita M.. AU - Sun, Ying. AU - Prasad, Paturu. AU - Chiaramida, Salvatore A.. AU - Lucariello, Richard J.. PY - 2001. Y1 - 2001. N2 - Left ventricular ejection fractions (LVEF) are routinely measured and result in critical decision-making algorithms in cardiology. This study was conducted to compare the accepted standard two-dimensional (2-D) echocardiogram ejection fraction (EFECHO) with single photon emission computed tomography rest ejection fraction (EFSPECT). Data were acquired and analyzed from 51 inpatients. EFECHO was obtained using modified Simpsons rule in the four-chamber apical view, and gated EFSPECT was computed by an automated method (Siemens ICON software). Comparison between EFECHO and EFSPECT was done by linear regression, Bland-Altman, and receiver operator ...
In a system which corrects for attenuation artifacts in a SPECT study, a line source is parallel to the axis of rotation of the scintillation camera detector(s) and is scanned in a plane which is parallel to the detector. Advantageously, the line source is initially scanned at high speed across the detector to acquire preliminary transmission CT data and is subsequently scanned across the detector at lower speed to acquire additional transmission CT data. During rescanning, the shuttering of the line source, and/or the speed of the line source, is varied. This acquires transmission CT data which is more reliable and from which the attenuation of the patient may be more accurately calculated.
Background: Coronary artery lesions in Kawasaki disease invasively assessed by coronary angiography. Evaluation of myocardial perfusion by single-photon emission computed tomography may identify the haemodynamic significance of coronary lesions. Obje
TY - JOUR. T1 - In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. AU - Carlson, Stephanie K.. AU - Classic, Kelly L.. AU - Hadac, Elizabeth M.. AU - Bender, Claire E.. AU - Kemp, Bradley J.. AU - Lowe, Val J.. AU - Hoskin, Tanya L.. AU - Russell, Stephen J.. PY - 2006/11/1. Y1 - 2006/11/1. N2 - Purpose: This study was undertaken to determine the ability of micro-single photon emission computed tomography (micro-SPECT)/computed tomography (CT) to accurately quantitate intratumoral radioisotope uptake in vivo and to compare these measurements with planar imaging and micro-SPECT imaging alone. Procedures: Human pancreatic cancer xenografts were established in 10 mice. Intratumoral radioisotope uptake was achieved via intratumoral injection of an attenuated measles virus vector expressing the NIS gene (MV-NIS). On various days after MV-NIS injection, 123I planar and micro-SPECT/CT imaging was performed. Tumor activity ...
Gilles Barone-Rochette, Mélanie Leclère, Alex Calizzano, Estelle Vautrin, Gallazzini-Crepin Céline, et al.. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography. Journal of Nuclear Cardiology, Springer Verlag, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩. ⟨inserm-02440579⟩ ...
Title: Microcirculation Dysfunction: A Possible Mechanism Responsible for Reverse Redistribution in Myocardial Perfusion Imaging?. VOLUME: 5 ISSUE: 4. Author(s):Yong-Ming He and Xiang-Jun Yang. Affiliation:Department of Cardiology, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province, Peoples Republic of China, 215006.. Keywords:Reverse redistribution, single photon emission tomography, coronary artery diseases, mechanism. Abstract: In the past more than one fourth century, the reverse redistribution (RR) phenomenon has been explored extensively and deeply, but its pathogenesis and clinical significances have remained unclear, which has perplexed nuclear specialists and cardiologists in the clinical practice. This paper reviewed the spectrum of the RR phenomenon in different entities and in different radiotracers. A close attention has been paid to the clinical significances, clinical approaching strategies and underlying mechanism of reverse redistribution in coronary ...
Accurate radio-theranostic imaging is becoming more and more important in both preclinical and clinical studies. Until now, only nuclear tracers with energies up to 350 keV could be used for quantitative SPECT imaging. MILabs new Stationary Clustered Pinhole (SCP) SPECT makes it now possible to image nuclear tracers up to 600 keV. This dramatically expands the application field of preclinical imaging for theranostic research: high-energy therapeutic tracers can be imaged directly; the dynamic behavior of radio-therapeutics can be studied; list-mode data enables post-acquisition dose optimization; and above all, the simultaneous acquisition of both SPECT and PET tracers makes it possible to obtain target specific information as well as to assess diseases treatment endpoints.. The authors of this publication demonstrate that the MILabs VECTor PET/SPECT/CT system can obtain images at sub-mm resolution in mice using low-dose 213Bi-labeled octreotate to trace and quantify radioactive uptake in ...
Free Online Library: Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints.(ORIGINAL ARTICLE) by Ear, Nose and Throat Journal; Health, general CAT scans CT imaging Head injuries Nervous system diseases Analysis Research Radiology Radiology, Medical Single photon emission computed tomography Usage SPECT imaging
肺移植後患者に対する肺換気/血流 SPECT/CT を用いた閉塞性細気管支炎症候群の診断的価値に関する検 ...
Noninvasive CT angiography and CT myocardial stress perfusion imaging can adequately predict heart attacks and major adverse cardiovascular events, according to a study published yesterday in Radiology-no invasive coronary angiography (ICA) required.. Invasive coronary angiography (ICA), along with stress tests and single photon emission tomography (SPECT) imaging, has long been the gold standard for making determinations of whether a lesion is hemodynamically significant and likely to result in major adverse cardiovascular events, reads a Radiological Society of North America press release.. But this gold standard has its drawbacks-in costs and risk.. Continue reading CT angiography and stress tests can predict heart attacks. ...
In both groups, patients undergo blood collection on day 0. Patients then undergo full-body single-photon emission-computed tomography (SPECT) scan 4 hours after cell infusion and on day 2. The labeling and imaging process may be repeated after at least 1 course of anticancer treatment.. Cellular uptake is measured by reader/visual interpretation, a semiquantitative grading system, and tumor-to-background uptake ratios.. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study. ...
NeuroLogica Corporation announced that it received CE Mark approval for its inSPira HD™: portable, high-resolution Single Photon Emission Computed Tom
Research Report on Global Single Photon Emission Computed Tomography (SPECT) Scanner Sales Market Report 2016. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. It scans images for diagnosis of heart disease and abnormalities.
Diagnostic medical test Single-photon emission computed tomography scan including diseases and symptoms diagnosed or ruled out by this test.
A single photon emission computed tomography system includes a base for supporting a patient and a detector assembly adjacent the field of view. The detector assembly detects photon strikes from the field of view. A photon-blocking member is disposed between the field of view and the detector and has an aperture slot that allows passage of photons aligned with the slot. A collimating assembly includes a plurality of collimating vanes formed of photon-attenuating material. A support assembly supports the collimating assembly and includes a first support member and a second support member with the collimating assembly being disposed therebetween. An adjustment assembly includes a first adjuster operable to adjust a first distance between the collimating assembly and the first support member and a second adjuster operable to adjust a second distance between the collimating assembly and the second support member.
Biological imaging ranges from the visualization of ions, molecules, cells and tissues to the non-invasive imaging of full size animals. The importance of imaging has grown tremendously since the development of methods and markers for live cell imaging, such as green fluorescent proteins confocal microscopy, as well as novel microscopic principles. Different in vivo imaging modalities such as computer tomography (CT), single photon emission computer tomography (SPECT) and magnetic resonance imaging (MRI) has given us tools to visualize structure, metabolism and function in a living body.. Modern imaging requires sophisticated instrumentation for data acquisition and methods of bioinformatics and data handling for their storage and analysis. The prerequisite for live cell imaging is that the equipment is near to the laboratories and animal centres. Therefore, each biocenter has confocal microscopes, video microscopes, and transmission electron microscopes for imaging of cells and tissues. ...
5.4 United States Single Photon Emission Computed Tomography Market Size by Application. …….Request for Sample with [email protected] https://www.researchtrades.com/request-sample/1685956. Who we are. Research Trades has a team of experts who is working on a comprehensive analysis of market research. This estimate is based on a comprehensive study of the future and estimates of future estimates, which can be used by various organizations for growth purposes. We distribute customized reports that focus on meeting the customers specific requirement. Our company provides a large collection of high-quality reports obtained by customer-centered approaches, thus providing valuable research insights.. Contact us ...
TY - JOUR. T1 - Perfusion scintigraphy of the heart and lungs in Ayerzas disease (practical case). AU - Vesnina, Zh V.. AU - Babokin, V. E.. AU - Chernov, V. I.. AU - Krivonogov, N. G.. AU - Sokolov, A. A.. AU - Markov, V. V.. AU - Gulyaev, V. M.. AU - Taranov, S. V.. AU - Lishmanov, Yu B.. PY - 2002. Y1 - 2002. N2 - The potential of perfusion scintigraphy is considered on the basic on the practical case. The patient with the preliminary diagnosis as myocardial ischemia was subjected to the 99mTc single-photon emission computerized tomography of myocardium and the 99mTc perfusion scintigraphy of lung. On the basis of obtained results the clinical diagnosis was thrombophlebitis of lower limbs, infarct-pneumonia, lung hypertension. But the pathologico-anatomic diagnosis was Ayerzas disease. The causes of the diagnostic error are discussed.. AB - The potential of perfusion scintigraphy is considered on the basic on the practical case. The patient with the preliminary diagnosis as myocardial ...
Semantic Scholar extracted view of Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebsteins anomaly through recognition of septal artifact. by Gabriel B. Grossman et al.
Introduction: Asymptomatic diabetic patients are at increased risk of cardiovascular complications. Myocardial perfusion scan may be effective in risk evaluation in this population. Methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method. Perfusion and function status was evaluated by qualitative and semi-quantitative parameters. Results: By visual analysis totally 40 out of 106 patients (37.7%) showed abnormal scan. From which, 26(24.5%) showed involvement in one, 13(12.3%) in two, and 1(0.9%) in all three vessel territories. By semi-quantitative method, from 103 patients, 28 (27.2%) were abnormal and 75 (72.8%) were normal. From all the asymptomatic diabetic patients, 11 patients (10.4%) had dilated left ventricles. Transient Ischemic Dilation (TID) was noted in 10
TY - JOUR. T1 - Dual-isotope myocardial perfusion spect with rest thallium-201 and stress Tc-99m sestamibi. AU - Berman, D. S.. AU - Kiat, H.. AU - Van Train, K.. AU - Friedman, J. D.. AU - Fan Ping Wang, Ping Wang. AU - Germano, G.. PY - 1994. Y1 - 1994. N2 - The commercial availability of Tc-99m-labeled myocardial perfusion agents had added choices in the noninvasive clinical assessment of coronary artery disease. Preferential use of Tc-99m sestamibi has been advocated principally due to improved image quality, which results from the combined physical and biological characteristics of this agent. This article reports upon the investigation of another approach for Tc-99m sestamibi SPECT-dual-isotope rest-stress myocardial perfusion SPECT, which takes advantage of the Anger cameras ability to collect date in different energy windows. For the dual- isotope approach, separate radiopharmaceuticals are employed for the rest injection and the stress injection.. AB - The commercial availability of ...
Background-The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography. Methods and Results-Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner. Quantitative perfusion parameters, such as blood flow, were calculated by parametric deconvolution for each myocardial voxel. Initially, perfusion parameters were extracted according to standard 17-segment model of the left ventricle (fully automatic analysis). These were then manually sampled by an operator (semiautomatic analysis). Areas under the receiver-operating characteristic curves of the 2 different approaches were compared. Invasive fractional flow reserve ≤0.80 or diameter ...
TY - JOUR. T1 - Comparison of 123I-MIBG myocardial scintigraphy, brain perfusion SPECT, and voxel-based MRI morphometry for distinguishing between dementia with Lewy bodies and Alzheimers disease. AU - Inui, Yoshitaka. AU - Toyama, Hiroshi. AU - Manabe, Yuta. AU - Sarai, Masayoshi. AU - Iwata, Nakao. PY - 2014/10/16. Y1 - 2014/10/16. N2 - Objective: This study aimed to compare the diagnostic value of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, N-isopropyl-p[123I]iodoamphetamine (IMP) brain perfusion single-photon emission computed tomography (SPECT), and brain magnetic resonance imaging (MRI) voxel-based morphometry (VBM) for the differentiation of dementia with Lewy bodies (DLB) and Alzheimers disease (AD).Methods: Thirty-five and 34 patients with probable DLB and probable AD, respectively, were enrolled. All patients underwent 123I-MIBG myocardial scintigraphy, 123I-IMP brain perfusion SPECT, and brain MRI. For 123I-MIBG imaging, we calculated early and delayed ...
Fingerprint Dive into the research topics of Impact of appropriate use on the prognostic value of single-photon emission computed tomography myocardial perfusion imaging. Together they form a unique fingerprint. ...
Ten infants with intractable seizures were examined with fluorodeoxyglucose positron emission tomography, xenon CT and HMPAO single photon emission computed tomography and with anatomical CT and MRI....
PURPOSE To characterize perfusion patterns of periictal single-photon emission tomography (SPECT) in patients with unilateral temporal lobe epilepsy (TLE) and to determine their relationship to the epileptogenic zone (EZ). METHODS We studied periictal SPECT scans of 53 patients after anterior mesial temporal lobectomy who had good seizure outcome after surgery. Ictal SPECT scans were performed during video-EEG monitoring. Typical SPECT patterns consisted of ipsilateral ictal hyperperfusion or ipsilateral postictal hypoperfusion. Atypical ictal patterns included normal scans, bilateral temporal hyperperfusion, or contralateral patterns. These perfusion patterns were retrospectively analyzed searching for concordance rate with the EZ. RESULTS We obtained 51 ictal and two early postictal scans. In the typical group, 40 (75.4%) patients had ipsilateral ictal temporal lobe hyperperfusion, and one (1.9%) patient had ipsilateral postictal temporal lobe hypoperfusion. Twelve (22.7%) patients exhibited
TY - JOUR. T1 - Perfusion vector-a new method to quantify myocardial perfusion scintigraphy images: a simulation study with validation in patients.. AU - Minarik, David. AU - Senneby, Martin. AU - Wollmer, Per. AU - Mansten, Alva. AU - Sjöstrand, Karl. AU - Edenbrandt, Lars. AU - Trägårdh, Elin. PY - 2015. Y1 - 2015. N2 - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective quantitative method for further assisting the visual interpretation and to test the concept using simulated MPS images as well as patients.. AB - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective ...
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This is the third in a series of papers using identical methodology to evaluate adherence to AUC for SPECT imaging in a single institution. The first publication dealt with patients from 2005 and demonstrated a substantial (14.4%) prevalence of inappropriate studies and furthermore identified four separate indications accounting for 88% of inappropriate studies including asymptomatic low-risk patients, which accounted for almost 50% of the inappropriate studies. A follow-up after publication of the AUC in 2006 demonstrated a significant decrease to 7.0% of inappropriate studies. The authors, at that time, engaged in a quality improvement project including grand rounds, publication of one page synopses of these studies, and other intramural educational activities designed to educate the referring physician base, and presumably further decrease the incidence of inappropriate studies. These educational and information sessions occurred predominantly in January 2008, and a third cohort of patients ...
Global Market report from QY Market Research on Single Photon Emission Computed Tomography Device Market 2018 in-depth complete study of the current state of the Single Photon Emission Computed Tomography Device worldwide.
We evaluated the feasibility of interictal single photon emission computed tomography (SPECT) to detect alterations in regional cerebral blood flow and neuronal activity in dogs with idiopathic epilepsy. Twelve dogs with idiopathic epilepsy underwent interictal technetium-99m-ethyl cysteinate dimer SPECT of the brain. Different cortical regions of interest (ROIs), 1 ROI at the cerebellum and 1 ROI at the subcortical area were evaluated by semiquantitative analysis and compared with a control group (18 dogs). Significant hypoperfusion (P=0.02) was present in the subcortical area of epileptic dogs. This hypoperfusion was not associated with seizure frequency, age at onset of seizures, duration of epilepsy, or time since the last seizure. Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy. ...
objective: to investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion spect images (bsi) from patients with temporal lobe epilepsy (tle). method: it was acquired interictal and ictal bsi from 24 patients with refractory t...
BACKGROUND: We evaluated the effects of attenuation correction and reconstruction techniques on the detection of hypoperfused lesions in brain SPECT imaging. METHODS: A software phantom was constructed using the data available on the BrainWeb database by assigning activity values to grey and white matter. The true attenuation map was generated by assigning attenuation coefficients to six different tissue classes to create a non-uniform attenuation map. The uniform attenuation map was calculated using an attenuation coefficient of 0.15 cm. Hypoperfused lesions of varying intensities and sizes were added. The phantom was then projected as typical SPECT projection data, taking into account attenuation and collimator blurring with the addition of Poisson noise. The projection data were reconstructed using four different methods: filtered back-projection in combination with Changs first-order attenuation correction using the uniform or the true attenuation map and maximum likelihood iterative ...
Objectives: Soft tissue attenuation artifacts are the most common cause of false-positives in myocardial perfusion SPECT (MPS). Few studies assessing the value
TY - JOUR. T1 - Myocardium perfusion scintigraphy in evaluation of endovascular treatment results of coronary artery disease. AU - Lishmanov, Yu B.. AU - Vesoina, J. V.. AU - Rybalchenko, E. V.. AU - Krylov, A. L.. PY - 2004. Y1 - 2004. N2 - Purpose: To determine abilities and principal features of prospective scintigraphic evaluation of endovascular treatment results of coronary artery disease (CAD) using thallium-199 perfusion single-photon emission computed tomography. Material and methods: Forty CAD patients were investigated by perfusion scintigraphy before and 2-3 weeks, 3-6 months and 1-2 years after coronary artery stenting. The character and size of perfusion defects and presence of the reverse radionuclide redistribution phenomenon were estimated. Results: The coronary stenting almost results to the 80 % decrease of mean size of transitory ischemic zones. The presence of reversible perfusion defects after operation was bound up with the incomplete revascularization or with X-syndrome. ...
Cardiovascular events remain one of the most frequent causes of mortality and morbidity worldwide. The majority of cardiac events occur in individuals without known coronary artery disease (CAD) and in low- to intermediate-risk subjects. Thus, the development of improved preventive strategies may substantially benefit from the identification, among apparently intermediate-risk subjects, of those who have a high probability for developing future cardiac events. Cardiac computed tomography and myocardial perfusion scintigraphy (MPS) by single photon emission computed tomography may play a role in this setting. In fact, absence of coronary calcium in cardiac computed tomography and inducible ischaemia in MPS are associated with a very low rate of major cardiac events in the next 3-5 years. Based on current evidence, the evaluation of coronary calcium in primary prevention subjects should be considered in patients classified as intermediate-risk based on traditional risk factors, since high calcium ...
Myocardial Perfusion Imaging is used to diagnose, and estimate the prognosis of patients with coronary artery disease. Increased attention around the use radiation in medical imaging coupled with new software allows the opportunity to try and reduce the radiation perfusion imaging by half. Software advances allow us to process images that have less radiation counts in the heart without losing the ability to determine the degree of heart disease. Patients underwent a usual dose and low dose stress myocardial perfusion technetium 99m study at the Ottawa Heart Institute. There were no significant differences between the images. The image quality and the parameters used determine significant heart disease were similar. We became an early adopter of the low dose studies and now routinely perform this on our patients. We also followed the first cohort of patients for 12 months to ensure that we saw no problems with doing a low dose test in the long term. Although we did not collect data on all of the ...
Fingerprint Dive into the research topics of Segmentation of the left ventricle in myocardial perfusion SPECT using variational level set formulation. Together they form a unique fingerprint. ...
Prognosis in patients with suspected or known ischemic heart disease and normal myocardial perfusion: Long-term outcome and temporal risk ...
The methods were validated and they have already been taken into use in hospitals all over the world. Coronary artery disease is the most common cause of death in the world, and a major cause of hospitalisation. Myocardial perfusion imaging (MPI), which is used to assess the sufficiency of myocardial blood flow, is an important tool in the diagnostics of coronary artery disease and in determining its severity. The scan is usually performed in two phases involving a stress myocardial perfusion imaging scan and a rest myocardial perfusion imaging scan. The patient is given an injection of a radioactive substance, which gets absorbed in those parts of the heart muscle that have normal blood flow. The scan is performed by using a gamma camera which detects radiation coming from the patient. The quality of images obtained by MPI are dependent on a variety of factors, the most significant ones being image noise, photon attenuation, Compton scattering, collimator-detector response (CDR), and patient ...
Abstract: : Purpose:To determine the effects of chronic retinal hypoperfusion on the physiological and morphological properties of the rat retina. Methods: Chronic retinal hypoperfusion was induced by unilateral and bilateral ligation of the common carotid arteries in anesthetized Long-Evans and Sprague-Dawley rats. Electroretinograms (ERGs) elicited by different stimulus intensities were recorded and histopathological studies performed up to 4 weeks postligation. Results: Injection of India ink in the heart demonstrated perfusion of both retinas following bilateral ligation. The a- and b-waves of the ERGs were significantly depressed by about 50% in the bilateral and unilateral (ipsilateral) ligated animals, although the thresholds were not as altered. The b-waves were more affected than the a-wave so that the b/a wave ratio was less than 1.0, a negative type ERG. There was a progressive decrease in the a- and b-waves with increasing postligation times. The thickness of the outer nuclear layer ...
Uniformly redundant array coded apertures have proven to be useful in the design of collimators for x-ray astronomy. They were initially expected to be equally successful in single-photon emission computed tomography (SPECT). Unfortunately, the SPECT images produced by this collimator contain artifacts, which mask the true picture and can lead to false diagnosis. Monte Carlo simulation has shown that the formation of a composite image will significantly reduce these artifacts. A simulation of a tumor in a compressed breast phantom has produced a composite image, which clearly indicates the presence of a 5 mm × 5 mm × 5 mm tumor with a 6:1 intensity ratio relative to the background tissue.. © 2002 Optical Society of America. Full Article , PDF Article ...
This Thesis investigates near infrared ( ~ 1550 nm) time-correlated singlephoton counting, studying the single-photon detectors and some of the potential application areas. Custom designed and fabricated InGaAs/InP single-photon avalanche diode detectors were characterised. Our devices yielded single-photon detection efficiencies of ~10 %, timing jitter of 200 ps, and noise equivalent power comparable to the best commercially available avalanche photodiodes operated in Geiger-mode. The afterpulsing phenomenon which limits the maximum count rate of InGaAs/InP single-photon avalanche diodes has been investigated in detail and activation energies calculated for the traps that cause this problem. This was found to be ~250 meV for all the devices tested, despite their differing structures and growth conditions, and points to the InP multiplication region as the likely location of the traps. Ways of reducing the effects caused by the afterpulsing phenomenon were investigated and sub-Geiger mode ...
The use of radionuclides has become more and more common in the diagnosis and therapy of cancer. Targeted radionuclide diagnostics and therapy based on the combination of appropriate radionuclides with selective delivery systems (e.g. antibody, peptides etc.) maximizes precision of the imaging as well as minimizes the damage of healthy tissues during therapy. Several imaging modalities using radionuclides including Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET) can be applied for non-invasive cancer visualization. Furthermore, based on imaging (tumor sizes and locations), appropriate therapeutic radionuclides emitting alpha, beta- particles or auger electrons can be utilized. This combination of radionuclides for diagnostics (imaging) and therapy by using the same delivery systems, named theranostic, has become state of the art in nuclear medicine. To broaden the number of radionuclides that can be applied in combination with organic delivery systems, ...
No model of brain function, including memory, will be complete until it can account for, and fully incorporate, the rare but spectacular condition of savant syndrome. In the past decade, particularly, much progress has been made towards explaining this jarring juxtaposition of ability and disability, but many unanswered questions remain. However, interest in this fascinating condition is accelerating, especially since the discovery of savant-type skills in previously unimpaired older persons with FTD and other acquired savant instances. This finding has far-reaching implications regarding buried potential in some or, perhaps, all of us.. Advanced technologies will help in those investigations. Computed tomography (CT) and MRI provide stunningly high-resolution images of all the brain architecture, surface and deep, permitting detailed inspection of brain structure. However, studies of brain function, such as positron emission tomography (PET), single photon emission CT (SPECT) or functional MRI, ...
This study validates estimation of EDV, ESV, and LVEF using ECTB, 4D-MSPECT, and QGS with cMRI as the gold standard and with gated SPECT and cMRI conducted under resting nonpost-stress conditions within a very close time interval. Seventy patients who were representative of the heterogeneous clinical coronary artery disease spectrum with the typical age range were included. To preclude significant changes in physiologic status between the resting examinations, cMRI in our study was either performed directly before gated 99mTc-MIBI SPECT or subsequent to it. The results assessed with ECTB were further compared with those obtained with 4D-MSPECT and QGS.. cMRI was chosen as the method of reference because it represents the accepted standard for measuring global function (21). Volumetric accuracy was ensured by high tissue contrast facilitating endocardial border definition (22,24). Nevertheless, it must be kept in mind that the 2-dimensional short-axis slices are acquired separately, not ...
Nuclear medicine Pet/Spect. Chapters 18 to 22. Activity. Number of radioactive atoms undergoing nuclear transformation per unit time. Change in radioactive atoms N in time dt Number of radioactive atoms decreases with time (- minus sign). Activity. Expressed in Curie Slideshow 83492 by...
Lowering the administered dose in SPECT myocardial perfusion imaging (MPI) has become an important clinical problem. In this study we investigate the potential benefit of applying a deep learning (DL) approach for suppressing the elevated imaging noise in low-dose SPECT-MPI studies. We adopt a supervised learning approach to train a neural network by using image pairs obtained from full-dose (target) and low-dose (input) acquisitions of the same patients. In the experiments, we made use of acquisitions from 1,052 subjects and demonstrated the approach for two commonly used reconstruction methods in clinical SPECT-MPI: 1) filtered backprojection (FBP), and 2) ordered-subsets expectation-maximization (OSEM) with corrections for attenuation, scatter and resolution. We evaluated the DL output for the clinical task of perfusion-defect detection at a number of successively reduced dose levels (1/2, 1/4, 1/8, 1/16 of full dose). The results indicate that the proposed DL approach can achieve substantial noise
Non-invasive images of the myocardium that reflect myocardial perfusion can be obtained either by using conventional nuclear medicine radiopharmaceuticals and cameras or by positron emission tomography (PET). Myocardial perfusion scintigraphy (MPS) with thallium-201 and/or technetium (Tc)-99m-labelled sestamibi and tetrofosmin, in combination with single photon emission computed tomography (SPECT), is a robust and well validated technique for the identification of myocardial ischaemia and infarction with high sensitivity and specificity. 99mTc-labelled myocardial perfusion agents have a high-count density which enables acquisition of electrocardiogram-gated images. Spatial and temporal changes in activity during the cardiac cycle reflect regional myocardial motion and thickening and this technique
PURPOSE: Ischaemic myocardial dysfunction shows different time courses of functional recovery according to the pathophysiological characteristics of the dysfunction. In this study, we investigated the time course of functional recovery according to the preoperative reversibility of perfusion impairment on myocardial single-photon emission computed tomography (SPECT) after revascularisation surgery. METHODS: Forty-eight patients (42 men and 6 women; mean age 59+/-9 years) who underwent revascularisation surgery were included in the study. 201Tl rest/dipyridamole stress (99m)Tc-sestamibi gated SPECT was performed 10+/-8 days before (preoperative), 105+/-13 days after (early follow-up) and 497+/-66 days after (late follow-up) surgery. Using a 20-segment model, segmental perfusion and thickening were quantified with automatic software. As an indicator of the reversibility of perfusion impairment, a reversibility score (RevS) was defined as a measure of rest minus stress perfusion values. Segmental ...
The work, which is being done under the title Project ProSPECTus, will be based on single photon emission computed tomography (SPECT) imaging - a technique that detects gamma rays emitted from a small amount of a radioactive pharmaceutical injected into the body.. Conventionally, an Anger Camera is used to do this. This camera relies on a collimator to filter some of the gamma rays through and to build a picture of the inner biological process of the patient.. However, ProSPECTus has taken a different approach by using what is known as the Compton Camera. This identifies the origin of the gamma rays without the use of a collimator, resulting in much less radiation being emitted during the process.. Dr Andy Boston, project spokesperson for Liverpool University, said that, because the radiation is used more efficiently, the sensitivity of the camera is improved, allowing the dose of radiation administered to the patient to be increased.. He added: [The technology] is unique in that it will ...
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope p
Myocardial perfusion imaging (MPI) is a commonly used diagnostic modality for risk stratification in patients with known or suspected coronary artery
OBJECTIVES: Although the prognostic value of quantitative single photon emission computed tomography myocardial perfusion imaging (MPI) with exercise and pharmacologic stress is well established, the prognostic and management value in the Medicare age population is less clear.. METHODS: The prospectively populated Cleveland Clinic nuclear cardiology database was used to identify 5,994 consecutive pateints, age ,65 years [1,664 (28%) exercise MPI, mean age 72.4±5.1, 74% male], who underwent MPI between January 2004 and January 2008. Clinical baseline variables, post test 90 days revascularization and MPI variables were analyzed. Overall and stratified nonparametric survival estimates were obtained by Kaplan-Meier method. Median follow-up time was 2.4 years. Parametric hazard modeling with bootstrap bagging methods was used to determine prognostic variables predicting mortality.. RESULTS: There was no difference in mortality in patients with an abnormal MPI vs. those with normal MPI. Amongst ...
SPECT myocardial perfusion imaging (MPI) is the most validated non-invasive method to test for ischemia, and this procedure is performed over 15 to
Introduction. Considerable doubt remains about whether the warm-up effect in angina represents ischaemic preconditioning (IPC), or is simply due to improved myocardial perfusion via acute recruitment of collaterals. We investigated the latter possibility using quantitative tetrofosmin SPECT. Methods. 11 patients (age 63±8 years, 8 male) with coronary disease and preserved left ventricular function underwent symptom-limited treadmill exercise off antianginal medication. On three separate days at weekly intervals, 99m Tc-tetrofosmin 400-450MBq was injected at rest, during a single exercise test (Ex1), and during the second of two exercise tests separated by 30 minutes (Ex2a and Ex2b). Exercise injections were given at equivalent heart rates. SPECT acquisitions were obtained 1-2 hours after each tetrofosmin injection. Quantitative analysis was performed by comparing polar plots derived from radial slices with a normal database. The hypoperfusion index was the product of
In a recent prospective, double-blind, randomized multicenter phase 3 trial, ADVANCE (Adenosine versus Regadenoson Comparative Evaluation for Myocardial Perfusion Imaging), the A2A selective adenosine receptor agonist, regadenoson, was shown to be noninferior to the nonselective vasodilator, adenosine, for detecting myocardial ischemia (1). The overall visual agreement was comparably low (in the low 60% range) for the adenosine-regadenoson and for the adenosine-adenosine comparisons. Conversely, when quantitative analysis was applied, regadenoson induced virtually identical results to adenosine-regarding the size and severity of left ventricular perfusion defect size and extent of ischemia (2). What are the regulatory implications of these findings? Should the regulatory bodies rely on subjective visual interpretation of myocardial perfusion studies, on objective quantitative programs to appraise the comparability between vasodilators, or both? What is the true standard?. In order to avoid the ...