Methods and Results-We randomized symptomatic women with suspected CAD, an interpretable ECG, and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies: ETT or exercise MPI. The primary end point was 2-year incidence of major adverse cardiac events, defined as CAD death or hospitalization for an acute coronary syndrome or heart failure. A total of 824 women were randomized to ETT or exercise MPI. For women randomized to ETT, ECG results were normal in 64%, indeterminate in 16%, and abnormal in 20%. By comparison, the exercise MPI results were normal in 91%, mildly abnormal in 3%, and moderate to severely abnormal in 6%. At 2 years, there was no difference in major adverse cardiac events (98.0% for ETT and 97.7% for MPI; P=0.59). Compared with ETT, index testing costs were higher for exercise MPI (P,0.001), whereas downstream procedural costs were slightly lower (P=0.0008). Overall, the cumulative diagnostic cost savings was 48% for ETT compared with ...
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up ...
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Brain perfusion SPECT is highly useful for the diagnosis of the dementias, including Alzheimers disease, Fronto-Temporal Dementia, and Lewy Body Disease. Studies of the accuracy of SPECT for diagnosing Alzheimers Disease report sensitivities of 65%-85% and specificities (for other dementias) of 72%-87% (1) In the largest study to date, both HMPAO SPECT and 18F-FDG PETwere able to completely separate 26 AD cases from controls (2) SPECT has been advocated over18F-FDG PET on the basis of its wider availability, lower cost, and perceived better patient tolerability, although a recent review suggested 18F-FDG PET had greater diagnostic accuracy over Brain Perfusion SPECT where available (3) Guidelines of the European Association of Nuclear Medicine and the American College of Radiology endorse the clinical use of Brain Perfusion SPECT in the workup and diagnosis of dementia (4,5).. Brain perfusion SPECT is useful because the clinical diagnosis of dementia is often inaccurate, especially in early ...
Background: Non-invasive diagnostic imaging of atherosclerotic coronary artery disease (CAD) is frequently carried out with cardiovascular magnetic resonance imaging (CMR) or myocardial perfusion single photon emission computed tomography (MPS). CMR is the gold standard for the evaluation of scar after myocardial infarction and MPS the clinical gold standard for ischemia. Magnetic Resonance Imaging (MRI) is at times difficult for patients and may induce anxiety while patient experience of MPS is largely unknown.. Aims: To evaluate image quality in CMR with respect to the sequences employed, the influence of atrial fibrillation, myocardial perfusion and the impact of patient information. Further, to study patient experience in relation to MRI with the goal of improving the care of these patients.. Method: Four study designs have been used. In paper I, experimental cross-over, paper (II) experimental controlled clinical trial, paper (III) psychometric crosssectional study and paper (IV) ...
RATIONALE AND OBJECTIVES: In the general context of perfusion pattern modeling from single-photon emission computed tomographic (SPECT) data, the purpose of this study is to characterize interindividual functional variability and functional connectivity between anatomic structures in a set of SPECT data acquired from a homogeneous population of subjects. MATERIALS AND METHODS: From volume of interest (VOI)-perfusion measurements performed on anatomically standardized SPECT data, we proposed to use correspondence analysis (CA) and hierarchical clustering (HC) to explore the structure of statistical dependencies among these measurements. The method was applied to study the perfusion pattern in two populations of subjects; namely, SPECT data from 27 healthy subjects and ictal SPECT data from 10 patients with mesio-temporal lobe epilepsy (MTLE). RESULTS: For healthy subjects, anatomic structures showing statistically dependent perfusion patterns were classified into four groups; namely, temporomesial
A very simple and low-cost brain dedicated, rapidly rotating Single Photon Emission Tomograph SPECT is described. Its use in following patients with ischemic stroke is illustrated by two middle cerebral artery occlusion cases, one with persistent occlusion and low CBF in MCA territory, and one with early lysis of the occlusion having high CBF (massive luxury perfusion) for some weeks. Evidence of this kind may be essential in the evaluation of therapeutic measures in ischemic stroke. ...
Background: It is of great clinical importance to exclude myocardial infarction in patients with suspected coronary artery disease who do not have stress-induced ischemia. The diagnostic use of myocardial perfusion single-photon emission computed tomography (SPECT) in this situation is sometimes complicated by attenuation artifacts that mimic myocardial infarction. Imaging in the prone position has been suggested as a method to overcome this problem. Methods: In this study, 52 patients without known prior infarction and no stress-induced ischemia on SPECT imaging were examined in both supine and prone position. The results were compared with cardiac magnetic resonance imaging (CMR) with delayed-enhancement technique to confirm or exclude myocardial infarction. Results: There were 63 defects in supine-position images, 37 of which disappeared in the prone position. None of the 37 defects were associated with myocardial infarction by CMR, indicating that all of them represented attenuation ...
Tracking coronary artery disease (CAD) via myocardial perfusion imaging (MPI) may have value in guiding therapeutic management for minimizing coronary event risk. Few studies have evaluated the effects of changes in myocardial perfusion as measured by positron emission tomography (PET MPI) on clinical outcomes. Accordingly, this study identified 552 patients who underwent serial rubidium-82 PET MPI for evaluation of suspected or known CAD. The extent of left ventricular (LV) stress perfusion defects was measured at both scans Objectivesly by automated software as the percentage of the LV mass with ,60% relative perfusion. All patients received aggressive medical therapy and 12% underwent interim revascularization. Mortality information was obtained through the National Death Index with mean follow-up of 2.5 years. Cox models were developed to estimate the effects of changes in stress perfusion defect size (change between serial scans in % of LV with stress perfusion defects) on all-cause and ...
TY - JOUR. T1 - Coronary stenosis severity assessed by 256-slice MDCT angiography in comparison with stress myocardial perfusion imaging. AU - Yonezawa, Masato. AU - Higuchi, K.. AU - Yamazaki, Y.. AU - Jinnouchi, M.. AU - Maruoka, Y.. AU - Isoda, T.. AU - Kamitani, T.. AU - Baba, S.. AU - Matsuo, Y.. AU - Abe, K.. AU - Honda, H.. PY - 2012/1/10. Y1 - 2012/1/10. N2 - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the diagnostic accuracy of MDCT for detecting myocardial ischemia by 201Tl SPECT. Fifty-three patients underwent both coronary CT angiography and stress myocardial perfusion SPECT. All coronary arteries were assessable with appropriate image quality. MDCT revealed high specificity, but only half of stenotic lesion by MDCT revealed ischemia on SPECT.. AB - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the ...
Objectives. We sought to evaluate the clinical use and cost-analysis of acute rest technetium-99m (Tc-99m) tetrofosmin single-photon emission computed tomographic (SPECT) myocardial perfusion imaging in patients with chest pain and a normal electrocardiogram (ECG).. Background. Current approaches used in emergency departments (EDs) for treating patients presenting with chest pain and a nondiagnostic ECG result in poor resource utilization.. Methods. Three hundred fifty-seven patients presenting to six centers with symptoms suggestive of myocardial ischemia and a nondiagnostic ECG underwent Tc-99m tetrofosmin SPECT during or within 6 h of symptoms. Follow-up evaluation was performed during the hospital period and 30 days after discharge. All entry ECGs, SPECT images and cardiac events were reviewed in blinded manner and were not available to the admitting physicians.. Results. By consensus interpretation, 204 images (57%) were normal, and 153 were abnormal (43%). Of 20 patients (6%) with an acute ...
For thousands of years, we, as humans, have sought to understand the mechanisms responsible for neural activity (Walsh, 1978). As long ago as 10,000 B.C., craniotomies are known to have been performed. In the 1500s, Vesalius published the first anatomic drawings of the brain after an unprecedented observation and dissection of the brain. In the 19th century, lesion studies introduced the lesion/deficit hypothesis of neural functioning, which subsequently led to much of the current functional neuroanatomical terminology (e.g., Brocas and Wernickes areas). Through the last few decades of what may be considered modern neural research, a "greater interest in the cognitive correlates of structural and functional brain lesions" has led to the development of todays technology for imaging the nervous system (Mega, 1999, p. 41 ...
Pharmacologic stress with dipyridamole has provided useful diagnostic, as well as prognostic, information in patients undergoing thallium-201 myocardial perfusion imaging. With its ultrashort half-life and a potent and consistent vasodilator effect, adenosine may be the coronary vasodilator of choice with myocardial perfusion imaging.. Fifty-one healthy subjects and 93 patients with suspected coronary artery disease constituted the study group. In this multicenter study the comparative safety and diagnostic efficacy of single-photon emission computed tomography (SPECT) thallium imaging during adenosine-induced coronary hyperemia was compared with exercise treadmill stress. There was a mean increase in heart rate of 37% and a mean decrease in diastolic blood pressure of 5% during the adenosine infusion of 140 μg/kg per min for 6 min. Adenosine infusion was well tolerated in 95% of the subjects. Side effects requiring intervention occurred in seven subjects (5%). None of the subjects experienced ...
DaTscanTM Ioflupane I123, a radiopharmaceutical will be used as an adjunct diagnostic tool in combination with single photon emission computed tomography
TY - JOUR. T1 - Cardiac contraction motion compensation in gated myocardial perfusion SPECT. T2 - A comparative study. AU - Salehi, Narges. AU - Rahmim, Arman. AU - Fatemizadeh, Emad. AU - Akbarzadeh, Afshin. AU - Farahani, Mohammad Hossein. AU - Farzanefar, Saeed. AU - Ay, Mohammad Reza. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Introduction: Cardiac contraction significantly degrades quality and quantitative accuracy of gated myocardial perfusion SPECT (MPS) images. In this study, we aimed to explore different techniques in motion-compensated temporal processing of MPS images and their impact on image quality and quantitative accuracy. Material and method: 50 patients without known heart condition underwent gated MPS. 3D motion compensation methods using Motion Freezing by Cedars Sinai (MF), Log-domain Diffeomorphic Demons (LDD) and Free-Form Deformation (FFD) were applied to warp all image phases to fit the end-diastolic (ED) phase. Afterwards, myocardial wall thickness, myocardial to blood pool ...
TY - JOUR. T1 - Gastric accommodation measurements by single photon emission computed tomography and two-dimensional scintigraphy in diabetic patients with upper gastrointestinal symptoms. AU - Chedid, Victor. AU - Halawi, Houssam. AU - Brandler, Justin. AU - Burton, Duane. AU - Camilleri, Michael. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objective: To compare estimates of gastric accommodation (GA) with single photon emission computed tomography (SPECT) to measurements based on intragastric meal distribution immediately post-meal ingestion (IMD 0 ). Methods: We evaluated 108 diabetics with upper gastrointestinal (UGI) symptoms who had undergone gastric emptying of solids (GE) by scintigraphy and GA measurements by SPECT. Immediately after ingestion of a 99m Tc-labeled egg meal (time 0), we estimated IMD 0 as radioactive counts or area of the proximal half of the stomach on two-dimensional images. Gastric volume (GV) during fasting and after 300 mL Ensure ® was measured by SPECT to quantify ...
Purpose: Shortening scan time and/or reducing radiation dose at maintained image quality are the main issues of the current research in radionuclide myocardial perfusion imaging (MPI). We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time). Methods: In this study, 50 patients, referred for evaluation of known or suspected coronary artery disease by SPECT MPI using 99mTc-Tetrofosmin, underwent 1-day adenosine stress 300MBq/rest 900MBq protocol with standard (stress 15min/rest 15min FULL time) immediately followed by short emission scan (stress 9min/rest 7min HALF time) on a Ventri SPECT camera (GE Healthcare). FULL time scans were processed with IR, short scans were additionally processed with a recently developed software algorithm for HALF time emission scans. All reconstructions were subsequently analyzed using commercially available software (QPS/QGS
Few-view single photon emission computed tomography (SPECT - Imaging: PET and SPECT Positron Emission Tomography Single Photon Emission Computed Tomography
Abstract. Background: An analysis of the US National Cardiovascular Data Registry has revealed that only 38% of patients referred for coronary angiography after non-invasive coronary testing have relevant coronary obstruction (CO) (≥70%) of one or more coronary arteries.. Methods: A single-center trial was undertaken in 165 consecutive, symptomatic patients with either known or suspected coronary disease and/or valve disease(VHD) who agreed to undergo cardiac catheterization and coronary angiography if stress myocardial perfusion imaging was abnormal. A total of 116 patients with abnormal SPECT MPI tests, persistent chest pain, or significant VHD underwent final analysis. An MCG coronary obstruction (CO) score of ≥ 4.0 was considered indicative of relevant CO (≥70%) in one or more coronary arteries. Angiographic results were finalized by consensus of two angiographers.. Results: CO (≥70%) was present in 53 of 116 patients (46%). The MCG CO score was significantly higher for patients with ...
In a system which corrects for attenuation artifacts in a SPECT study, a line source is parallel to the axis of rotation of the scintillation camera detector(s) and is scanned in a plane which is parallel to the detector. Advantageously, the line source is initially scanned at high speed across the detector to acquire preliminary transmission CT data and is subsequently scanned across the detector at lower speed to acquire additional transmission CT data. During rescanning, the shuttering of the line source, and/or the speed of the line source, is varied. This acquires transmission CT data which is more reliable and from which the attenuation of the patient may be more accurately calculated.
Background: Coronary artery lesions in Kawasaki disease invasively assessed by coronary angiography. Evaluation of myocardial perfusion by single-photon emission computed tomography may identify the haemodynamic significance of coronary lesions. Obje
TY - JOUR. T1 - In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography. AU - Carlson, Stephanie K.. AU - Classic, Kelly L.. AU - Hadac, Elizabeth M.. AU - Bender, Claire E.. AU - Kemp, Bradley J.. AU - Lowe, Val J.. AU - Hoskin, Tanya L.. AU - Russell, Stephen J.. PY - 2006/11/1. Y1 - 2006/11/1. N2 - Purpose: This study was undertaken to determine the ability of micro-single photon emission computed tomography (micro-SPECT)/computed tomography (CT) to accurately quantitate intratumoral radioisotope uptake in vivo and to compare these measurements with planar imaging and micro-SPECT imaging alone. Procedures: Human pancreatic cancer xenografts were established in 10 mice. Intratumoral radioisotope uptake was achieved via intratumoral injection of an attenuated measles virus vector expressing the NIS gene (MV-NIS). On various days after MV-NIS injection, 123I planar and micro-SPECT/CT imaging was performed. Tumor activity ...
Gilles Barone-Rochette, Mélanie Leclère, Alex Calizzano, Estelle Vautrin, Gallazzini-Crepin Céline, et al.. Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography. Journal of Nuclear Cardiology, Springer Verlag, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩. ⟨inserm-02440579⟩ ...
Free Online Library: Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints.(ORIGINAL ARTICLE) by Ear, Nose and Throat Journal; Health, general CAT scans CT imaging Head injuries Nervous system diseases Analysis Research Radiology Radiology, Medical Single photon emission computed tomography Usage SPECT imaging
肺移植後患者に対する肺換気/血流 SPECT/CT を用いた閉塞性細気管支炎症候群の診断的価値に関する検 ...
Noninvasive CT angiography and CT myocardial stress perfusion imaging can adequately predict heart attacks and major adverse cardiovascular events, according to a study published yesterday in Radiology-no invasive coronary angiography (ICA) required.. Invasive coronary angiography (ICA), along with stress tests and single photon emission tomography (SPECT) imaging, has long been the "gold standard" for making determinations of whether a lesion is hemodynamically significant and likely to result in major adverse cardiovascular events, reads a Radiological Society of North America press release.. But this "gold standard" has its drawbacks-in costs and risk.. Continue reading CT angiography and stress tests can predict heart attacks. ...
In both groups, patients undergo blood collection on day 0. Patients then undergo full-body single-photon emission-computed tomography (SPECT) scan 4 hours after cell infusion and on day 2. The labeling and imaging process may be repeated after at least 1 course of anticancer treatment.. Cellular uptake is measured by reader/visual interpretation, a semiquantitative grading system, and tumor-to-background uptake ratios.. PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study. ...
NeuroLogica Corporation announced that it received CE Mark approval for its inSPira HD™: portable, high-resolution Single Photon Emission Computed Tom
Research Report on Global Single Photon Emission Computed Tomography (SPECT) Scanner Sales Market Report 2016. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. It scans images for diagnosis of heart disease and abnormalities.
Diagnostic medical test Single-photon emission computed tomography scan including diseases and symptoms diagnosed or ruled out by this test.
A single photon emission computed tomography system includes a base for supporting a patient and a detector assembly adjacent the field of view. The detector assembly detects photon strikes from the field of view. A photon-blocking member is disposed between the field of view and the detector and has an aperture slot that allows passage of photons aligned with the slot. A collimating assembly includes a plurality of collimating vanes formed of photon-attenuating material. A support assembly supports the collimating assembly and includes a first support member and a second support member with the collimating assembly being disposed therebetween. An adjustment assembly includes a first adjuster operable to adjust a first distance between the collimating assembly and the first support member and a second adjuster operable to adjust a second distance between the collimating assembly and the second support member.
Biological imaging ranges from the visualization of ions, molecules, cells and tissues to the non-invasive imaging of full size animals. The importance of imaging has grown tremendously since the development of methods and markers for live cell imaging, such as green fluorescent proteins confocal microscopy, as well as novel microscopic principles. Different in vivo imaging modalities such as computer tomography (CT), single photon emission computer tomography (SPECT) and magnetic resonance imaging (MRI) has given us tools to visualize structure, metabolism and function in a living body.. Modern imaging requires sophisticated instrumentation for data acquisition and methods of bioinformatics and data handling for their storage and analysis. The prerequisite for live cell imaging is that the equipment is near to the laboratories and animal centres. Therefore, each biocenter has confocal microscopes, video microscopes, and transmission electron microscopes for imaging of cells and tissues. ...
The most important aspects of nuclear medicine imaging systems such as Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) are the spatial resolution and the sensitivity (detector efficiency in combination with the geometric efficiency). Considerable efforts have been spent during the last two decades in improving the resolution and the efficiency by developing new detectors. Our proposed improvement technique is focused on the readout and electronics. Instead of using traditional pulse height analysis techniques we propose using free running digital sampling by replacing the analog readout and acquisition electronics with fully digital programmable systems.. This thesis describes a fully digital data acquisition system for KS/SU SPECT, new algorithms for high resolution timing for PET, and modular FPGA based decentralized data acquisition system with optimal timing and energy. The necessary signal processing algorithms for energy assessment and high ...
sir Stress thalium test result shows the following results:- SA.HLA & VLA section taken post stress and during rest reveal -no stress indused I.V.dilation. - reversible perfusion defect in anterior...
Question - Tentative dilated right ventricle, done electrocardiogram, normal stress test. Family history of bad heart. Worried.. Ask a Doctor about when and why X ray is advised, Ask a Cardiac Surgeon
Thieme eBooks, Internationally renowned authorities in the field of hybrid imaging contribute firsthand expertise on the practical application of single-photon emission computed tomography (SPECT) and SPECT/CT. By combining clear anatomic markers from CT with functional knowledge from SPECT, SPECT/CT provides added value for patient evaluation and is becoming increasingly prevalent in routine clinical practic...
We thank Dr. Schaaf and colleagues for their interest in our work (1). The responses to their questions are as follows:. Dr. Schaaf and colleagues comment on why changes in the myocardium at risk (MaR) do not occur during the first week, in parallel with infarct size and extracellular volume (ECV). Independent of MaR, we demonstrated that infarct size by late gadolinium enhancement cardiac magnetic resonance (CMR) is larger acutely than on day 7 compared with histopathology using triphenyltetrazolium chloride staining, and this results in different salvage acutely and on day 7 (1). However, when salvage is determined with triphenyltetrazolium chloride as the infarct reference and MaR from T2-weighted (T2w) CMR, the results are similar at both time points (1). Thus, an overestimation of MaR in the acute phase is unlikely. Furthermore, T2w CMR has been validated against myocardial single-photon emission computed tomography (SPECT) (2,3), and the extent of edema was unchanged 1 week after ...
Fund BioImag Emission computed tomography Heart and rodent examples perfusion of heart muscle -orange, yellow: good perfusion -blue, purple: poor perfusion SPECT Image of a small mouse (25 gr) injected with 10 millicuries of 99mTc-MDP.
Like you, thousands of our customers around the world rely on advanced imaging techniques to study dynamic biological process within living animals. To better understand the progression and treatment of diseases, you can use Albiras PET, SPECT and CT imaging for quantitative 3D tomographic imaging of radiotracers, bone, and soft tissue. Below are just a few of the applications of the Albira system that can provide deep insight into the underlying mechanisms of diseases and the effectiveness of new therapeutics:. ...
... : Cardiac SPECT Imaging Pub Date: December 2000 Product Type: Print Author/s: E. G DePuey MD; Ernest V Garcia
The preoperative use of a new hybrid imaging single-photon emission CT modality improved the detection of metastatic lymph nodes and increased disease-free survival in patients with cutaneous melanoma
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I just got the results from my SPECT scan. I havent talked to Dr Hyde, but he forwarded me the results because he had some questions for me. I am a...
トレッドミル運動負荷断層タリウム心筋シンチグラフィ(^,201,Tl-SPECT)による6年間の心疾患長期予後の検討 Prediction of 6-year Prognosis for Cardiac Event by Thallium-201 Single-Photon Emission Computed Tomography(SPECT) with Treadmill Exercise Test ...
Theranostics will play a significant role in the next-generation chemotherapy. Two novel tumor-targeting theranostic drug conjugates, bearing imaging arms, were designed and synthesized. These theranostic conjugates consist of biotin as the tumor-targeting moiety, a second generation taxoid, SB-T-1214, as a potent anticancer drug, and two different imaging arms for capturing 99mTc for SPECT (single photon emission computed tomography) and 64Cu for PET (positron emission tomography). To explore the best reaction conditions for capturing radionuclides and work out the chemistry directly applicable to "hot" nuclides, cold chemistry was investigated to capture 185Re(I) and 63Cu(II) species as surrogates for 99mTc and 64Cu, respectively ...
Patient with stenosis in the proximal segment of LAD classified as ≥50% on CTCA related with large and reversible perfusion defects (ischemia) in apex, anteri
Good afternoon, I have have started a new doctor who ran a few blood tests. When I asked for the results, I noticed that some of them were bolded. I...
Pyntril not only helps manage normal stress and promote a sense of calmness but also helps with occasional discomforts throughout the body. With a unique blend of herbs this product helps maintain a normal and relaxed disposition, balances the central nervous system, and supports immunity. If your animal is hyper or if
Analytical solutions for either the shear stress or the normal stress differences in large-amplitude oscillatory shear flow, both for continuum or molecular models, often take the form of the first few terms of a power ...