Engineering technology is that part of the technological field which requires the application of scientific and engineering knowledge and methods, combined with technical skills, for the implementation and extension of existing technologies. Engineering technology education focuses on preparing engineering technologists for positions that involve product development and improvement, system development, management, manufacturing and engineering operational functions. Graduates also enter the technical sales and customer services field, or continue in graduate work in engineering or management. Placement of graduates has been excellent.. The Engineering Technology Program awards Bachelor of Science in Engineering Technology (BSET) degrees for each of the following degree options: Construction Engineering Technology (CET), Electrical and Computer Engineering Technology (ECET), Mechanical Engineering Technology (MET), Medical Informatics Technology (MIT), Surveying Engineering Technology (SET), and ...
A key factor in the tissue engineering approach to tissue repair and regeneration is the use of appropriate cells. Mesenchymal stem cells (MSCs) are derived from bone marrow stroma or connective tissues and they have the potential to differentiate into various mesenchymal cell lines in vitro and in vivo. These cells hold great promise for musculoskeletal tissue engineering. This review is based mainly on the work which has been done in the National University of Singapore on the use of MSCs for engineering cartilage, growth plate, bone and tendon/ligament as well as the clinical trail of autologous chondrocyte implantation. It can help to shape future research on musculosketetal tissue engineering ...
The ability to heal soft tissue injuries and regenerate cartilage is the Holy Grail of musculoskeletal medicine. Articular cartilage repair and regeneration is considered to be largely intractable due to the poor regenerative properties of this tissue. Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or continue hypertrophic cartilage. The lack of efficient modalities of treatment has prompted research into tissue engineering combining stem cells, scaffold materials and environmental factors. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased cartilage functionality, has evoked intense interest and holds great potential for improving cartilage therapy. Plasma-rich ...
[email protected] Engineering Technology is a technologically advanced program at the Bachelor of Science level utilizing theoretical concepts and hands-on instruction. Program selection is from the following concentrations: Computer Engineering Technology, Electromechanical Engineering Technology, and Mechanical Engineering Technology.. The Mechanical Engineering Technology concentration requires 67 hours is accredited by ABET, Inc. (http://www.abet.org) and enables students to obtain the skills necessary for placement in highly competitive jobs in machine design, manufacturing, engineering, field service engineering, technical sales, thermal analysis, product design, utilities operations, air conditioning design, plant operations, and a variety of other professions. Through design projects and laboratory training, students examine how to relate such skills to a variety of fields in mechanical engineering technology including product and machine design, power generation, utilities, and ...
This thesis presents a foundation for developing a business case for companies interested in the reconstructive and cosmetic procedure markets. The focus is on reviewing adipose tissue engineering research and proposing technology opportunities that could be applied to challenging soft tissue reconstruction cases and adjacently applied to cosmetic applications. To establish the foundation for this type of program, this thesis includes an evaluation of the reconstructive and cosmetic procedure markets, current practices in these markets and their constraints, as well as a literature review of research in adipose tissue engineering and its potential clinical applications. Additionally it captures the competitive landscape of major players in the reconstructive market as well as up-and-coming players in the adipose tissue engineering field. Technology development opportunities with associated customer and business value are discussed with a recommendation for the development of a detailed business ...
The cardiovascular tissue engineering laboratory aims to develop tissue engineering and cell-based therapeutic approaches for the treatment of cardiac injury and disease.
Cardiac tissue engineering is an emerging field that may hold great promise for advancing the treatment of heart diseases. Cardiac tissue engineering is in its infancy, and the overall field of tissue engineering, which was formalized in the late 1980s at conferences and workshops sponsored by the National Science Foundation, is still new enough to warrant some description. By broad definition, tissue engineering involves the construction of tissue equivalents through the manipulation and combination of living cells and biomaterials. It is a multidisciplinary field combining diverse aspects of the life sciences, engineering, and clinical medicine. The overall goal of tissue engineering is to develop tissue equivalents for use in the repair, replacement, maintenance, or augmentation of tissues or organs. Although some aspects of cardiac tissue engineering research have been ongoing for generations, albeit without being known as such, directed efforts in the field are only beginning.. The main ...
Bone marrow derived mesenchymal stem cells (bmMSCs) are widely used for the generation of tissue engineering constructs, since they can differentiate into different cell types occurring in bone tissues. Until now their use for the generation of tissue engineering constructs is limited. All cells inside a tissue engineering construct die within a short period of time after implantation of the construct because vascularization and establishment of connections to the recipient circulatory system is a time consuming process. We therefore compared the influences of bmMSC, VEGF and a combination of both on the early processes of vascularization, utilizing the mice skinfold chamber model and intravital fluorescence microscopy.. Tissue engineering constructs based on collagen coated Poly d,l-lactide-co-glycolide (PLGA) scaffolds, were either functionalized by coating with vascular endothelial growth factor (VEGF) or vitalized with bmMSC. PLGA without cells and growth factor was used as the control ...
TY - JOUR. T1 - Electrically Stimulated Adipose Stem Cells on Polypyrrole-Coated Scaffolds for Smooth Muscle Tissue Engineering. AU - Björninen, Miina. AU - Gilmore, Kerry. AU - Pelto, Jani. AU - Seppänen-Kaijansinkko, Riitta. AU - Kellomäki, Minna. AU - Miettinen, Susanna. AU - Wallace, Gordon. AU - Grijpma, Dirk. AU - Haimi, Suvi. N1 - EXT="Pelto, Jani". PY - 2016/11/14. Y1 - 2016/11/14. N2 - We investigated the use of polypyrrole (PPy)-coated polymer scaffolds and electrical stimulation (ES) to differentiate adipose stem cells (ASCs) towards smooth muscle cells (SMCs). Since tissue engineering lacks robust and reusable 3D ES devices we developed a device that can deliver ES in a reliable, repeatable, and cost-efficient way in a 3D environment. Long pulse (1 ms) or short pulse (0.25 ms) biphasic electric current at a frequency of 10 Hz was applied to ASCs to study the effects of ES on ASC viability and differentiation towards SMCs on the PPy-coated scaffolds. PPy-coated scaffolds promoted ...
In recent years, significant success has been made in the field of regenerative medicine. Tissue engineering scaffolds have been developed to repair and replace different types of tissues. The overall goal of the current work was to develop scaffolds of native extracellular matrix components for soft tissue regeneration, more specifically, neural tissue engineering. To date, much research has been focused on developing a nerve guidance scaffold for its ability to fill and heal the gap between the damaged nerve ends. Such scaffolds are marked by several intrinsic properties including: (1) a biodegradable scaffold or conduit, consisting of native ECM components, with controlled internal microarchitecture; (2) support cells (such as Schwann cells) embedded in a soft support matrix; and (3) sustained release of bioactive factors. In the current dissertation, we have developed such scaffolds of native biomaterials including hyaluronic acid (HA) and collagen. HA is a nonsulphated, unbranched, ...
TY - JOUR. T1 - Carboxymethyl cellulose - Hydroxyapatite hybrid hydrogel as a composite material for bone tissue engineering applications. AU - Pasqui, Daniela. AU - Torricelli, Paola. AU - De Cagna, Milena. AU - Fini, Milena. AU - Barbucci, Rolando. PY - 2014. Y1 - 2014. N2 - Natural bone is a complex inorganic-organic nanocomposite material, in which hydroxyapatite (HA) nanocrystals and collagen fibrils are well organized into hierarchical architecture over several length scales. In this work, we reported a new hybrid material (CMC-HA) containing HA drown in a carboxymethylcellulose (CMC)-based hydrogel. The strategy for inserting HA nanocrystals within the hydrogel matrix consists of making the freeze-dried hydrogel to swell in a solution containing HA microcrystals. The composite CMC-HA hydrogel has been characterized from a physicochemical and morphological point of view by means of FTIR spectroscopy, rheological measurements, and field emission scanning electron microscopy (FESEM). No ...
In situ tissue engineering has become a promising new technique to restore native tissue structure and function by providing a microenvironment necessary to promote tissue regeneration. A biodegradable synthetic starter matrix (scaffold) is introduced to the body to provide this microenvironment at the place of interest. By initiating an inflammatory response upon implantation, a natural wound healing process can be induced to regenerate new tissue. In time, the scaffold will be replaced by this newly formed tissue, resulting in a native, living tissue with growth potential and the capability of remodeling. Within this project, we particularly focus on using in situ tissue engineering to create living heart valves and arteries, as an alternative to the conventional heart valve and small diameter artery replacement therapies, which are accompanied by considerable decrease of life expectancy and therapy-induced complications.
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Bone is the second most transplanted tissue in the body, with approximately 2.2 million bone graft procedures performed annually worldwide. Currently, autogenous bone is the gold standard for bone grafting due to its ability to achieve functional healing; however, it is limited in supply and results in secondary injury at the donor site. Tissue engineering has emerged as a promising means for the development of new bone graft substitutes in order to overcome the limitations of the current grafts. In this research project, the specific approach for bone tissue engineering involves seeding osteoprogenitor cells within a biomaterial scaffold then culturing this construct in a biodynamic bioreactor. The bioreactor imparts osteoinductive mechanical stimuli on the cells to stimulate the synthesis of an extracellular matrix rich in osteogenic and angiogenic factors that are envisioned to guide bone healing in vivo. Fluid flow, which exerts a hydrodynamic shear stress on adherent cells, has been ...
Blood vessels mimics (BVMs) are tissue-engineered blood vessels used to test vascular devices in an environment that mimics some simple anatomical factors of native blood vessels. It is important to accurately and consistently assess tissue-engineered blood vessels, although there is currently a lack of standardization in Cal Polys Tissue Engineering Lab and in the entirety of the field. The goal of this thesis was to develop and optimize imaging and image quantification techniques for tissue-engineered blood vessels. The first aim of this thesis optimized and compared imaging and assessment techniques for electrospun scaffolds. Images from different SEMs were compared to determine the benefits and drawbacks of each microscope. Several materials were also imaged using these microscopes to characterize polymers at the microscopic scale and to compare the quality of images from different SEMs. The second aim of this thesis validated and implemented a MATLAB-based automatic fiber diameter measurement tool
Novel tissue engineering approaches are emerging to meet regenerative medicine demands and challenges towards successful therapies to completely restore the function in damaged or degenerated tissues. Among them, magnetic tissue engineering envisions the development of complex systems in which magnetic elements are exploited as remotely controlled multidimensional tools with potential for diagnostic and therapeutic actions. This chapter provides an overview of the latest developments in the design and assessment of magnetic tissue engineering strategies with particular emphasis on smart magnetic materials and their relevance for tissue regeneration. Special attention will be given to the fabrication of sophisticated systems from the nano to the macro scale, and to the role of magnetic smart materials for providing alternative approaches to address the demanding tissue requirements and meet successful alternative strategies for regenerative medicine. The cellular response to the presence of ...
Automotive Engineering Technology (BS). Electrical/Electronics Engineering Technology (BS). Manufacturing Engineering Technology (BS). Manufacturing Tooling Technology (AAS). Mechanical Engineering Technology (BS). Plastics Engineering Technology(BS). Plastics Technology (AAS). Product Design Engineering Technology (BS). Quality Engineering Technology (BS). Mechanical Engineering Technology (AAS). ...
View Notes - Stem Cells in Tissue Engineering from BIO 4400 at Cornell. Stem Cells in Tissue Engineering 4/16/07 Definition 1: g g gg p Tissue engineering is the emerging discipline of design and
Myocardial Infarction leads to end-stage heart failure and it is the major cause of death in many industrialized nations. Tissue engineering approaches for treatment of the infarcted tissue has gained huge attention over the recent years and research in this direction mainly aims for the optimization of a biomaterial scaffold with cell-source for tissue regeneration. In this regard, we fabricated absolutely natural polymeric composite scaffolds, using the blood protein, namely fibrinogen, the denatured collagen glycoprotein gelatin and collagen by electrospinning process. Scaffolds with different weight ratios of fibrinogen:gelatin (Fib:Gel) and Fibrinogen:Collagen (Fib:Coll) was prepared and cross-linking (CL) of the electrospun scaffolds was carried out using glutaraldehyde vapors to improve their mechanical properties. The fiber diameters of the fabricated scaffolds were in the range of 150 ? 300 nm which was close to the size of the native protein fibers in the myocardial extracellular ...
Advances in Materials Science and Engineering is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of materials science and engineering.
Cartilage tissue engineering remains a top priority due to the limited intrinsic capacity of articular cartilage for self-repair. In this study, the tissue engineering potential of a decellularized porcine cartilage scaffold, in which the proteoglycans (PG) had also been removed, was evaluated. To improve cell distribution within the scaffold, a novel cell seeding technique using centrifugation and a cell seeding device designed for this technique was developed. The modified porcine cartilage scaffolds were seeded with chondrocytes using the novel cell seeding technique and left in static culture for up to 21 days. A previously described bioreactor was used to measure the properties of the constructs at 7, 14, and 21 days. The ability of the scaffolds to support cell viability and proliferation and extracellular matrix deposition was evaluated at these time points as well. The novel cell seeding technique was also evaluated at 24 hours. Results indicated that the scaffold was capable of supporting cell
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Tissue Engineering Society International Annual Conference, Oct. 24, 2005. First Clinical Use of Tissue Engineered Blood Vessels in the Adult Arterial Circulation. Nicolas L´Heureux, Todd McAllister, Sergio Garrido, Alicia Marini, Hernan Avila, Luis de la Fuente, Ximena Manglano, Robert C Robbins, Gerhardt Konig, Nathalie Dusserre. The historical challenge in the field of Cardiovascular Tissue Engineering has been to produce a conduit with the appropriate mechanical strength (i.e. burst pressure in excess of 1700 mmHg). To achieve the requisite strength, most approaches have relied upon permanent synthetic or xenogeneic scaffolds. These scaffolds, however, may be associated with chronic inflammation, disease transmission, or mechanical degradation that limit their clinical use. In an effort to eliminate the deleterious effects of permanent biomaterials, more recent trends have focused on either resorbable scaffolds or completely biological approaches. Previously we reported a completely ...
We have previously reported on the use of Bay K8644-release strategies in combination with perfusion-compression bioreactor systems for up regulating bone formation in three-dimensional PLLA scaffolds. Here we report on the analysis of Bay activity following its release from our PLLA scaffolds over the culture period imposed in our tissue engineering protocol using UV spectroscopy in combination with whole cell patch clamping techniques. Bay was released continually from scaffolds within the physiological range required for agonist activity (1-10 microM). Patch clamping allowed for the effects of Bay released from scaffolds to be monitored directly with respect to osteoblast electrophysiology. A characteristic shift in the current-voltage (I-V) relationship of L-type VOCC currents was observed in rat osteoblast sarcoma (ROS) cells patched in a solution with Bay released from scaffolds following 14 and 28 days incubation, with statistically significant differences observed in peak currents compared to
Autologous tissue-engineered blood vessels (TEBVs) generated using adult stem cells have shown promising results, but many preclinical evaluations do not test the efficacy of stem cells from patient populations likely to need therapy (i.e., elderly and diabetic humans). Two critical functions of these cells will be (i) secreting factors that induce the migration of host cells into the graft and (ii) differentiating into functional vascular cells themselves. The purpose of this study was to analyze whether adipose-derived mesenchymal stem cells (AD-MSCs) sourced from diabetic and elderly patients have a reduced ability to promote human smooth muscle cell (SMC) migration and differentiation potential toward SMCs, two important processes in stem cell-based tissue engineering of vascular grafts ...
Cardiac tissue engineering (CTE) is currently a prime focus of research due to an enormous clinical need. In this work, a novel functional material, Poly(3-hydroxyoctanoate), P(3HO), a medium chain length polyhydroxyalkanoate (PHA), produced using bacterial fermentation, was studied as a new potential material for CTE. Engineered constructs with improved mechanical properties, crucial for supporting the organ during new tissue regeneration, and enhanced surface topography, to allow efficient cell adhesion and proliferation, were fabricated. Our results showed that the mechanical properties of the final patches were close to that of cardiac muscle. Biocompatibility of the P(3HO) neat patches, assessed using Neonatal ventricular rat myocytes (NVRM), showed that the polymer was as good as collagen in terms of cell viability, proliferation and adhesion. Enhanced cell adhesion and proliferation properties were observed when porous and fibrous structures were incorporated to the patches. Also, no ...
CR (n = 10) were removed from the bypass system after surgery. Isolation was performed using different isolation methods: blood samples were taken from the cardiopulmonary bypass and centrifuged at low density. The venous filter screen was cut out and placed into petri dishes for cultivation. The spongelike filter was removed, washed and treated in the same way as the blood samples. After cultivation, cell lines of fibroblasts (FB) and endothelial cells (EC) were obtained for analysis. The cells were seeded on polyurethane patches and analyzed via scanning electron microscopy (SEM), Life/Dead assay and immunohistochemistry.. ...
THESIS 8757 Tissue engineering (or regenerative medicine) is defined as the application of scientific principles to the synthesis of living tissues using bioreactors, cells, scaffolds, growth factors, or a combination (Rose and Oreffo, 2002). One of the principal methods in tissue engineering involves the use of a porous scaffold to support and guide synthesis of a 3D tissue or organ (Sachlos and Czernuszka, 2003). Collagen-Glycosaminoglycan scaffolds have found success in several clinical applications of tissue engineering (Yannas et al., 1989, Chamberlain et al., 1998). ...
Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the books content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option. ...
This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs). We provide experimental evidence to show that activation of the cannabinoid system enhances the survival, migration and chondrogenic differentiation of MSCs, which are three major tenets behind the success of a cell-based tissue-engineered cartilage repair strategy. These findings highlight the potential for cannabinoids to provide a dual function by acting as anti-inflammatory agents as well as regulators of MSC biology in order to enhance tissue engineering strategies aimed at cartilage repair.
Until now, Tissue Engineering techniques have frequently been shown to be promising in vitro and in vivo in experimental settings, but have widely failed to enter the clinical routine when it comes to large defects or major organ functional replacements [13]. One of the key roles for this insufficient transition into clinical practice has been discussed to be dependent on the lack of sufficient vasculature at the time of transplanting laboratory-grown constructs into relevant and especially into poorly vascularized recipient areas. Large bone defects present a prototype of such difficult to handle clinical replacement problems, as vascularized bone grafts are associated with a significant donor-site morbidity and non-vascularized bone grafts do not heal into problematic sites. The optimal bone graft for any successful reconstruction of a large osseus defect would consist of a custom-designed vascularized bone substitute without creating any donor-site morbidity. Almost all bone tissue ...
Bektas, C. K., & Hasirci, V. (2018). Mimicking Corneal Stroma Using Keratocyte Loaded Photopolymerizable Methacrylated Gelatin Hydrogels. Journal of Tissue Engineering and Regenerative Medicine.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Paul W Riem Vis, Carlijn V C Bouten, Joost P G Sluijter, Gerard Pasterkamp, Lex A van Herwerden, Jolanda Kluin].
The US Food and Drug Administration approves a device, seeded with a patient’s own cells, which can help repair damaged knee cartilage—a first for autologous cartilage technology.
Worldwide market for Tissue Engineering technologies explored in this study includes Cell Culture, Immunomodulation and Stem Cell. The report also focuses on therapeutic applications of tissue engineering comprising Cardiovascular, Dental/Oral Neurological, Oncology, Orthopedic, Skin/Integumentary and Others. The markets for the above mentioned technologies and therapeutic applications are analyzed in terms of USD. Global market for Tissue Engineering, estimated at US$23 billion in 2015, forecast to reach US$27.3 billion in 2015, and is further expected to register a CAGR of about 23% between 2016 and 2022 to touch a projected US$94.2 billion by 2022.
Nanotechnology-enabled tissue engineering is receiving increasing attention. The ultimate goal of tissue engineering as a medical treatment concept is to replace or restore the anatomic structure and function of damaged, injured, or missing tissue. At the core of tissue engineering is the construction of three-dimensional scaffolds out of biomaterials to provide mechanical support and guide cell growth into new tissues or organs. Biomaterials can be variously permanent or biodegradable, naturally occurring or synthetic, but inevitably need to be biocompatible. Using nanotechnology, biomaterial scaffolds can be manipulated at atomic, molecular, and macromolecular levels. Creating tissue engineering scaffolds in nanoscale also may bring unpredictable new properties to the material, such as mechanical (stronger), physical (lighter and more porous) or chemical reactivity (more active or less corrosive), which are unavailable at micro- or macroscales. For bone tissue engineering, a special subset of ...
A new study by researchers at UCLA suggests that the elasticity of the physical matrix used for growing heart muscle cells outside of the body may be critical to the success of cardiac tissue engineering. The results were ...
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The Broadcast Engineering Technology Specialization Scholarship is available to students at Georgia Piedmont Technical College. You must be majoring in electrical / computer engineering technology ...
Design Engineering, Engineering, Engineering Adhesives, Engineering Design, Engineering Equipment & Products, Engineering Fabrication, Engineering Industries, Engineering Pipeline Construction, Engineering Plastic, Engineering Publications, Engineering Services, Engineering Sub Surface Services, Engineering Workshops, Foundation Engineering, Light Engineering, Mechanical Engineering Contractors, Power Engineering, Project Engineering, Road Safety Services & Traffic Engineering, Systems Engineering, Textile Engineering, Water Engineering,
Design Engineering, Engineering, Engineering Adhesives, Engineering Design, Engineering Equipment & Products, Engineering Fabrication, Engineering Industries, Engineering Pipeline Construction, Engineering Plastic, Engineering Publications, Engineering Services, Engineering Sub Surface Services, Engineering Workshops, Foundation Engineering, Light Engineering, Mechanical Engineering Contractors, Power Engineering, Project Engineering, Road Safety Services & Traffic Engineering, Systems Engineering, Textile Engineering, Water Engineering,
Theres a lot of interest in soft materials, particularly biomaterials," explains Guenther of the materials that help create functional tissue cultures, "but until now no one has demonstrated a simple and scalable one-step process to go from microns to centimeters." How exactly does a machine grow a large patch of living tissue?. Scientists manipulate biomaterials into the micro-device through several channels. The biomaterials are then mixed, causing a chemical reaction that forms a "mosaic hydrogel"-a sheet-like substance compatible with the growth of cells into living tissues, into which different types of cells can be seeded in very precise and controlled placements.. Unique to this new approach to tissue engineering, however, and unlike more typical methods for tissue engineering (for instance, scaffolding, the seeding of cells onto an artificial structure capable of supporting three-dimensional tissue formation) cells planted onto the mosaic hydrogel sheets are precisely incorporated into ...
The regeneration of new bone or cartilage to restore the function of traumatized, damaged, or lost bone or cartilage is a major clinical and socioeconomic burden. In recent years, a new cutting-edge procedure, bone- and cartilage-tissue engineering, has emerged as a new strategy for healing musculoskeletal conditions. In this strategy, progenitors or mature cells are combined with biocompatible scaffolds to initiate partial or full bone and/or cartilage regeneration.Scaffolding materials in tissue engineering should be bioactive and biodegradable. The synthetic polymers, such as PLA and PGA, are biodegradable, but not bioactive. Furthermore, their bulky degradation style and induction of foreign body reaction limit their clinical applications. Chitosan and alginate, two natural polymers, have proven to be biodegradable and bioactive for bone and cartilage regeneration. In this study, high-concentration (4.8% w/v) chitosan-alginate hybrid scaffolds were successfully synthesized through a ...
Skin loss is one of the oldest and still not totally resolved problems in the medical field. Since spontaneous healing of the dermal defects would not occur, the regeneration of full thickness of skin requires skin substitutes. Tissue engineering constructs would provide a three dimensional matrix for the reconstruction of skin tissue and the repair of damage. The aim of the present work is to develop a chitin based scaffold, by blending it with poly(butylene succinate) (PBS), an aliphatic, biodegradable and biocompatible synthetic polymer with excellent mechanical properties. The presence of chondroitin sulfate nanoparticles (CSnp) in the scaffold would favor cell adhesion. A chitin/PBS/CSnp composite hydrogel scaffold was developed and characterized by SEM (Scanning Electron Microscope), FTIR (Fourier Transform Infrared Spectroscopy), and swelling ratio of scaffolds were analyzed. The scaffolds were evaluated for the suitability for skin tissue engineering application by cytotoxicity, cell attachment,
Temporomandibular Joint Cartilage and Bone Regeneration and Biomechanics. Functional tissue engineering techniques; development of novel bioreactors; identifying appropriate stem cell sources; genetic manipulation of cells to promote regeneration; and quantification of joint movement ...
Introduction to tissue engineering: definition and historical prespective Limitations of existing biomaterials solutions. Highlighting the important medical needs. Cell biology cell types, stem cells, intracellular structures (membrane, cytoskeleton, nucleus) important signalling molecules Biochemistry and concept of molecular biology Cell growth and differentiation pathways, mechanisms and control, extracellular matrix, epithelial mesenchymal interactions, matrix molecules and their ligands, gene expression, concept of mechanotransduction. In vitro control of tissue development cell culture and specific needs for different cell types, growth factors, models for tissue engineering, physical characteristics for transplantation, cell function in constructs; influence of mechanical, chemical and extracellular matrix environment. Construct Technology 3-D structure, multi-cellular systems, transport of nutrients and metabolites in tissue engineering, bioreactors for tissue engineered constructs,
... MARQUETTE Mich. and GREENVILLE N.C. Feb. 23 /- Pio... The patented E-Matrix technology provides a bioscaffold for leadin... Ronald S. Hill PhD Vice President of Research and Development s... Pioneer continues to focus on commercializing these novel technolo...,Pioneer(R),Surgical,Technology,,Inc.,Wins,Frost,&,Sullivans,2009,North,American,Orthopaedic,Tissue,Engineering,Technology,Innovation,Award,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
In the 1970s and 1980s, tissue engineers began working on growing replacement organs for transplantation into patients. While scientists are still targeting that goal, much of the tissue engineering research at MIT is also focused on creating tissue that can be used in the lab to model human disease and test potential new drugs.. This kind of disease modeling could have a great impact in the near term, says MIT professor Sangeeta Bhatia, who is developing liver tissue to study hepatitis C and malaria infection.. Like other human tissues, liver is difficult to grow outside the human body because cells tend to lose their function when they lose contact with neighboring cells. "The challenge is to grow the cells outside the body while maintaining their function after being removed from their usual microenvironment," says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.. Bhatia recently developed the first ...
Buyuksungur, S., Endogan Tanir, T., Buyuksungur, A., Bektas, E. I., Torun Kose, G., Yucel, D., Beyzadeoglu, T., Cetinkaya, E., Yenigun, C., Tönük, E., Hasirci, V., Hasirci, N. (2017). 3D printed poly(ε-caprolactone) scaffolds modified with hydroxyapatite and poly(propylene fumarate) and their effects on the healing of rabbit femur defects. Biomaterials Science. DOI: 10.1039/c7bm00514h ...